NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|16080639|ref|NP_391467|]
View 

gamma-DD-glutamyl hydrolase (PGA depolymerase) [Bacillus subtilis subsp. subtilis str. 168]

Protein Classification

C40 family peptidase( domain architecture ID 11435042)

C40 family peptidase is a cell-wall hydrolase that cleaves peptide cross-bridges between glycan chains and is essential for bacterial growth and viability; typically cleaves the linkage between D-Glu and diaminopimelic acid (or Lys) within peptidoglycan stem peptides; contains a Cys-His-His catalytic triad

EC:  3.4.-.-
Gene Ontology:  GO:0008233|GO:0016787|GO:0006508
MEROPS:  C40
PubMed:  18715016|12620121|31216697|11517925

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
NlpC COG0791
Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];
133-286 1.16e-49

Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 440554 [Multi-domain]  Cd Length: 218  Bit Score: 167.57  E-value: 1.16e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080639 133 QSKGVIITNYKKSSYWSGTYIGARRIAADPATADVPVVQEAEKYIGVPYVFGGSTPSeGFDCSGLVQYVFQQAlGIYLPR 212
Cdd:COG0791  67 VGSAGAAAAAAAAKAGSSAAKSAAGASAPPSSTAEAIVAAALSYLGTPYVWGGTSPS-GFDCSGLVQYVYRQA-GISLPR 144

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 16080639 213 SAEQQWAVGEKVAPQNIKPGDVVYFsNTYKTGISHAGIYAGAGRFIQASRSEK-VTISYLSEDYWKSKMTGIRRF 286
Cdd:COG0791 145 TSADQAAAGTPVSRSELQPGDLVFF-RTGGGGISHVGIYLGNGKFIHASSSGKgVRISSLDSPYWKSRYVGARRV 218
NlpC COG0791
Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];
30-158 2.27e-39

Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 440554 [Multi-domain]  Cd Length: 218  Bit Score: 140.60  E-value: 2.27e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080639  30 AEADTSSELIVSEAKNLLGYQYKYGGETPKeGFDPSGLIQYVFSKADIHLPRSVNDQYKIGTAVKPENLKPGDILFFKke 109
Cdd:COG0791  94 APPSSTAEAIVAAALSYLGTPYVWGGTSPS-GFDCSGLVQYVYRQAGISLPRTSADQAAAGTPVSRSELQPGDLVFFR-- 170

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 16080639 110 gSTGTVPTHDALYIGDGQMVHSTQSK-GVIITNYkKSSYWSGTYIGARRI 158
Cdd:COG0791 171 -TGGGGISHVGIYLGNGKFIHASSSGkGVRISSL-DSPYWKSRYVGARRV 218
NLPC_P60 pfam00877
NlpC/P60 family; The function of this domain is unknown. It is found in several lipoproteins.
 308-411 4.88e-28

NlpC/P60 family; The function of this domain is unknown. It is found in several lipoproteins.


:

Pssm-ID: 395705 [Multi-domain]  Cd Length: 105  Bit Score: 106.21  E-value: 4.88e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080639   308 VPYKQGGVTPeTGFDTAGFVQYVYQKAaGISLPRYATSQYNAGTK-IEKADLKPGDIVFFQSTSlNPS---IYIGNGQVV 383
Cdd:pfam00877   2 VPYRWGGGSP-SGFDCSGLVRYAFAKV-GIELPRSSGQQYNAGKKtIPKSEPQRGDLVFFGTGK-GIShvgIYLGNGQML 78

                          90       100
                  ....*....|....*....|....*...
gi 16080639   384 HVTLSNGVTITNMNTStYWKDKYAGSIR 411
Cdd:pfam00877  79 HASTGGGVSISSLNGG-YWQKRLVGVRR 105
 
Name Accession Description Interval E-value
NlpC COG0791
Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];
133-286 1.16e-49

Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440554 [Multi-domain]  Cd Length: 218  Bit Score: 167.57  E-value: 1.16e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080639 133 QSKGVIITNYKKSSYWSGTYIGARRIAADPATADVPVVQEAEKYIGVPYVFGGSTPSeGFDCSGLVQYVFQQAlGIYLPR 212
Cdd:COG0791  67 VGSAGAAAAAAAAKAGSSAAKSAAGASAPPSSTAEAIVAAALSYLGTPYVWGGTSPS-GFDCSGLVQYVYRQA-GISLPR 144

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 16080639 213 SAEQQWAVGEKVAPQNIKPGDVVYFsNTYKTGISHAGIYAGAGRFIQASRSEK-VTISYLSEDYWKSKMTGIRRF 286
Cdd:COG0791 145 TSADQAAAGTPVSRSELQPGDLVFF-RTGGGGISHVGIYLGNGKFIHASSSGKgVRISSLDSPYWKSRYVGARRV 218
NLPC_P60 pfam00877
NlpC/P60 family; The function of this domain is unknown. It is found in several lipoproteins.
 178-285 1.26e-40

NlpC/P60 family; The function of this domain is unknown. It is found in several lipoproteins.


Pssm-ID: 395705 [Multi-domain]  Cd Length: 105  Bit Score: 139.73  E-value: 1.26e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080639   178 GVPYVFGGSTPSeGFDCSGLVQYVFQQAlGIYLPRSAEQQWAVGEKVAP-QNIKPGDVVYFSNTYktGISHAGIYAGAGR 256
Cdd:pfam00877   1 GVPYRWGGGSPS-GFDCSGLVRYAFAKV-GIELPRSSGQQYNAGKKTIPkSEPQRGDLVFFGTGK--GISHVGIYLGNGQ 76

                          90       100
                  ....*....|....*....|....*....
gi 16080639   257 FIQASRSEKVTISYLSEDYWKSKMTGIRR 285
Cdd:pfam00877  77 MLHASTGGGVSISSLNGGYWQKRLVGVRR 105
NlpC COG0791
Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];
30-158 2.27e-39

Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440554 [Multi-domain]  Cd Length: 218  Bit Score: 140.60  E-value: 2.27e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080639  30 AEADTSSELIVSEAKNLLGYQYKYGGETPKeGFDPSGLIQYVFSKADIHLPRSVNDQYKIGTAVKPENLKPGDILFFKke 109
Cdd:COG0791  94 APPSSTAEAIVAAALSYLGTPYVWGGTSPS-GFDCSGLVQYVYRQAGISLPRTSADQAAAGTPVSRSELQPGDLVFFR-- 170

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 16080639 110 gSTGTVPTHDALYIGDGQMVHSTQSK-GVIITNYkKSSYWSGTYIGARRI 158
Cdd:COG0791 171 -TGGGGISHVGIYLGNGKFIHASSSGkGVRISSL-DSPYWKSRYVGARRV 218
NLPC_P60 pfam00877
NlpC/P60 family; The function of this domain is unknown. It is found in several lipoproteins.
 51-157 6.35e-29

NlpC/P60 family; The function of this domain is unknown. It is found in several lipoproteins.


Pssm-ID: 395705 [Multi-domain]  Cd Length: 105  Bit Score: 108.91  E-value: 6.35e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080639    51 YKYGGETPKeGFDPSGLIQYVFSKADIHLPRSVNDQYKIGTAVKPEN-LKPGDILFFKkegsTGTVPTHDALYIGDGQMV 129
Cdd:pfam00877   4 YRWGGGSPS-GFDCSGLVRYAFAKVGIELPRSSGQQYNAGKKTIPKSePQRGDLVFFG----TGKGISHVGIYLGNGQML 78

                          90       100
                  ....*....|....*....|....*...
gi 16080639   130 HSTQSKGVIITNYkKSSYWSGTYIGARR 157
Cdd:pfam00877  79 HASTGGGVSISSL-NGGYWQKRLVGVRR 105
NLPC_P60 pfam00877
NlpC/P60 family; The function of this domain is unknown. It is found in several lipoproteins.
 308-411 4.88e-28

NlpC/P60 family; The function of this domain is unknown. It is found in several lipoproteins.


Pssm-ID: 395705 [Multi-domain]  Cd Length: 105  Bit Score: 106.21  E-value: 4.88e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080639   308 VPYKQGGVTPeTGFDTAGFVQYVYQKAaGISLPRYATSQYNAGTK-IEKADLKPGDIVFFQSTSlNPS---IYIGNGQVV 383
Cdd:pfam00877   2 VPYRWGGGSP-SGFDCSGLVRYAFAKV-GIELPRSSGQQYNAGKKtIPKSEPQRGDLVFFGTGK-GIShvgIYLGNGQML 78

                          90       100
                  ....*....|....*....|....*...
gi 16080639   384 HVTLSNGVTITNMNTStYWKDKYAGSIR 411
Cdd:pfam00877  79 HASTGGGVSISSLNGG-YWQKRLVGVRR 105
spr PRK10838
bifunctional murein DD-endopeptidase/murein LD-carboxypeptidase;
178-285 8.23e-26

bifunctional murein DD-endopeptidase/murein LD-carboxypeptidase;


Pssm-ID: 236773 [Multi-domain]  Cd Length: 190  Bit Score: 103.31  E-value: 8.23e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080639  178 GVPYVFGGSTPSeGFDCSGLVQYVFQQALGIYLPRSAEQQWAVGEKVAPQNIKPGDVVYFSnTYKTGiSHAGIYAGAGRF 257
Cdd:PRK10838  79 GVRYRLGGSTKK-GIDCSAFVQRTFREQFGLELPRSTYEQQEMGKSVSRSKLRTGDLVLFR-AGSTG-RHVGIYIGNNQF 155

                         90       100
                 ....*....|....*....|....*...
gi 16080639  258 IQASRSEKVTISYLSEDYWKSKMTGIRR 285
Cdd:PRK10838 156 VHASTSSGVIISSMNEPYWKKRYNEARR 183
spr PRK10838
bifunctional murein DD-endopeptidase/murein LD-carboxypeptidase;
308-412 2.80e-25

bifunctional murein DD-endopeptidase/murein LD-carboxypeptidase;


Pssm-ID: 236773 [Multi-domain]  Cd Length: 190  Bit Score: 101.77  E-value: 2.80e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080639  308 VPYKQGGVTpETGFDTAGFVQYVYQKAAGISLPRYATSQYNAGTKIEKADLKPGDIVFFQ--STSLNPSIYIGNGQVVHV 385
Cdd:PRK10838  80 VRYRLGGST-KKGIDCSAFVQRTFREQFGLELPRSTYEQQEMGKSVSRSKLRTGDLVLFRagSTGRHVGIYIGNNQFVHA 158

                         90       100
                 ....*....|....*....|....*..
gi 16080639  386 TLSNGVTITNMNtSTYWKDKYAGSIRV 412
Cdd:PRK10838 159 STSSGVIISSMN-EPYWKKRYNEARRV 184
spr PRK10838
bifunctional murein DD-endopeptidase/murein LD-carboxypeptidase;
48-158 3.05e-21

bifunctional murein DD-endopeptidase/murein LD-carboxypeptidase;


Pssm-ID: 236773 [Multi-domain]  Cd Length: 190  Bit Score: 90.59  E-value: 3.05e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080639   48 GYQYKYGGETpKEGFDPSGLIQYVFSKA-DIHLPRSVNDQYKIGTAVKPENLKPGDILFFKKeGSTGtvpTHDALYIGDG 126
Cdd:PRK10838  79 GVRYRLGGST-KKGIDCSAFVQRTFREQfGLELPRSTYEQQEMGKSVSRSKLRTGDLVLFRA-GSTG---RHVGIYIGNN 153

                         90       100       110
                 ....*....|....*....|....*....|..
gi 16080639  127 QMVHSTQSKGVIITNYkKSSYWSGTYIGARRI 158
Cdd:PRK10838 154 QFVHASTSSGVIISSM-NEPYWKKRYNEARRV 184
NlpC_inact_RipD NF033743
NlpC/P60 family peptidoglycan-binding protein RipD; RipD proteins, such as founding member ...
 61-134 5.91e-18

NlpC/P60 family peptidoglycan-binding protein RipD; RipD proteins, such as founding member Rv1566c from Mycobacterium tuberculosis, is a catalytically inactive paralog of the peptidoglycan endopeptidases RipA and RipB. A catalytically important Cys and His pair is replaced by Ala-83 and Ser-132.


Pssm-ID: 468164 [Multi-domain]  Cd Length: 177  Bit Score: 80.89  E-value: 5.91e-18
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 16080639   61 GFDPSGLIQYVFSKADIHLPRSVNDQYKIGTAVKPENLKPGDILFFKKEGsTGTVpthdALYIGDGQMVHSTQS 134
Cdd:NF033743  88 GFDASGLMVYAFAGAGVKLPRSSGEQYKVGQKVLPAQALPGDLIFYGPEG-TQSV----ALFLGNGQMLEATDP 156
 
Name Accession Description Interval E-value
NlpC COG0791
Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];
133-286 1.16e-49

Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440554 [Multi-domain]  Cd Length: 218  Bit Score: 167.57  E-value: 1.16e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080639 133 QSKGVIITNYKKSSYWSGTYIGARRIAADPATADVPVVQEAEKYIGVPYVFGGSTPSeGFDCSGLVQYVFQQAlGIYLPR 212
Cdd:COG0791  67 VGSAGAAAAAAAAKAGSSAAKSAAGASAPPSSTAEAIVAAALSYLGTPYVWGGTSPS-GFDCSGLVQYVYRQA-GISLPR 144

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 16080639 213 SAEQQWAVGEKVAPQNIKPGDVVYFsNTYKTGISHAGIYAGAGRFIQASRSEK-VTISYLSEDYWKSKMTGIRRF 286
Cdd:COG0791 145 TSADQAAAGTPVSRSELQPGDLVFF-RTGGGGISHVGIYLGNGKFIHASSSGKgVRISSLDSPYWKSRYVGARRV 218
NLPC_P60 pfam00877
NlpC/P60 family; The function of this domain is unknown. It is found in several lipoproteins.
 178-285 1.26e-40

NlpC/P60 family; The function of this domain is unknown. It is found in several lipoproteins.


Pssm-ID: 395705 [Multi-domain]  Cd Length: 105  Bit Score: 139.73  E-value: 1.26e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080639   178 GVPYVFGGSTPSeGFDCSGLVQYVFQQAlGIYLPRSAEQQWAVGEKVAP-QNIKPGDVVYFSNTYktGISHAGIYAGAGR 256
Cdd:pfam00877   1 GVPYRWGGGSPS-GFDCSGLVRYAFAKV-GIELPRSSGQQYNAGKKTIPkSEPQRGDLVFFGTGK--GISHVGIYLGNGQ 76

                          90       100
                  ....*....|....*....|....*....
gi 16080639   257 FIQASRSEKVTISYLSEDYWKSKMTGIRR 285
Cdd:pfam00877  77 MLHASTGGGVSISSLNGGYWQKRLVGVRR 105
NlpC COG0791
Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];
30-158 2.27e-39

Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440554 [Multi-domain]  Cd Length: 218  Bit Score: 140.60  E-value: 2.27e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080639  30 AEADTSSELIVSEAKNLLGYQYKYGGETPKeGFDPSGLIQYVFSKADIHLPRSVNDQYKIGTAVKPENLKPGDILFFKke 109
Cdd:COG0791  94 APPSSTAEAIVAAALSYLGTPYVWGGTSPS-GFDCSGLVQYVYRQAGISLPRTSADQAAAGTPVSRSELQPGDLVFFR-- 170

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 16080639 110 gSTGTVPTHDALYIGDGQMVHSTQSK-GVIITNYkKSSYWSGTYIGARRI 158
Cdd:COG0791 171 -TGGGGISHVGIYLGNGKFIHASSSGkGVRISSL-DSPYWKSRYVGARRV 218
NlpC COG0791
Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];
205-412 2.49e-36

Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440554 [Multi-domain]  Cd Length: 218  Bit Score: 132.52  E-value: 2.49e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080639 205 ALGIYLPRSAEQQWAVGEKVAPQNIKPGDVVYFSNTYKTGISHAGIYAGAGRFIQASRSEKVTISYLSEDYWKSKMTGIR 284
Cdd:COG0791   6 ALAAALAAAAAALAAVAAAGALAAADAAVAAALVAAAAAVLAAAALLAGPAAAVAGAAAPAVGSAGAAAAAAAAKAGSSA 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080639 285 RFDNLTIPKENP-----IVSEATLYVGeVPYKQGGVTPeTGFDTAGFVQYVYqKAAGISLPRYATSQYNAGTKIEKADLK 359
Cdd:COG0791  86 AKSAAGASAPPSstaeaIVAAALSYLG-TPYVWGGTSP-SGFDCSGLVQYVY-RQAGISLPRTSADQAAAGTPVSRSELQ 162

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 16080639 360 PGDIVFFQSTSLNPS---IYIGNGQVVHVTLS-NGVTITNMNtSTYWKDKYAGSIRV 412
Cdd:COG0791 163 PGDLVFFRTGGGGIShvgIYLGNGKFIHASSSgKGVRISSLD-SPYWKSRYVGARRV 218
NLPC_P60 pfam00877
NlpC/P60 family; The function of this domain is unknown. It is found in several lipoproteins.
 51-157 6.35e-29

NlpC/P60 family; The function of this domain is unknown. It is found in several lipoproteins.


Pssm-ID: 395705 [Multi-domain]  Cd Length: 105  Bit Score: 108.91  E-value: 6.35e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080639    51 YKYGGETPKeGFDPSGLIQYVFSKADIHLPRSVNDQYKIGTAVKPEN-LKPGDILFFKkegsTGTVPTHDALYIGDGQMV 129
Cdd:pfam00877   4 YRWGGGSPS-GFDCSGLVRYAFAKVGIELPRSSGQQYNAGKKTIPKSePQRGDLVFFG----TGKGISHVGIYLGNGQML 78

                          90       100
                  ....*....|....*....|....*...
gi 16080639   130 HSTQSKGVIITNYkKSSYWSGTYIGARR 157
Cdd:pfam00877  79 HASTGGGVSISSL-NGGYWQKRLVGVRR 105
NLPC_P60 pfam00877
NlpC/P60 family; The function of this domain is unknown. It is found in several lipoproteins.
 308-411 4.88e-28

NlpC/P60 family; The function of this domain is unknown. It is found in several lipoproteins.


Pssm-ID: 395705 [Multi-domain]  Cd Length: 105  Bit Score: 106.21  E-value: 4.88e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080639   308 VPYKQGGVTPeTGFDTAGFVQYVYQKAaGISLPRYATSQYNAGTK-IEKADLKPGDIVFFQSTSlNPS---IYIGNGQVV 383
Cdd:pfam00877   2 VPYRWGGGSP-SGFDCSGLVRYAFAKV-GIELPRSSGQQYNAGKKtIPKSEPQRGDLVFFGTGK-GIShvgIYLGNGQML 78

                          90       100
                  ....*....|....*....|....*...
gi 16080639   384 HVTLSNGVTITNMNTStYWKDKYAGSIR 411
Cdd:pfam00877  79 HASTGGGVSISSLNGG-YWQKRLVGVRR 105
spr PRK10838
bifunctional murein DD-endopeptidase/murein LD-carboxypeptidase;
178-285 8.23e-26

bifunctional murein DD-endopeptidase/murein LD-carboxypeptidase;


Pssm-ID: 236773 [Multi-domain]  Cd Length: 190  Bit Score: 103.31  E-value: 8.23e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080639  178 GVPYVFGGSTPSeGFDCSGLVQYVFQQALGIYLPRSAEQQWAVGEKVAPQNIKPGDVVYFSnTYKTGiSHAGIYAGAGRF 257
Cdd:PRK10838  79 GVRYRLGGSTKK-GIDCSAFVQRTFREQFGLELPRSTYEQQEMGKSVSRSKLRTGDLVLFR-AGSTG-RHVGIYIGNNQF 155

                         90       100
                 ....*....|....*....|....*...
gi 16080639  258 IQASRSEKVTISYLSEDYWKSKMTGIRR 285
Cdd:PRK10838 156 VHASTSSGVIISSMNEPYWKKRYNEARR 183
spr PRK10838
bifunctional murein DD-endopeptidase/murein LD-carboxypeptidase;
308-412 2.80e-25

bifunctional murein DD-endopeptidase/murein LD-carboxypeptidase;


Pssm-ID: 236773 [Multi-domain]  Cd Length: 190  Bit Score: 101.77  E-value: 2.80e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080639  308 VPYKQGGVTpETGFDTAGFVQYVYQKAAGISLPRYATSQYNAGTKIEKADLKPGDIVFFQ--STSLNPSIYIGNGQVVHV 385
Cdd:PRK10838  80 VRYRLGGST-KKGIDCSAFVQRTFREQFGLELPRSTYEQQEMGKSVSRSKLRTGDLVLFRagSTGRHVGIYIGNNQFVHA 158

                         90       100
                 ....*....|....*....|....*..
gi 16080639  386 TLSNGVTITNMNtSTYWKDKYAGSIRV 412
Cdd:PRK10838 159 STSSGVIISSMN-EPYWKKRYNEARRV 184
spr PRK10838
bifunctional murein DD-endopeptidase/murein LD-carboxypeptidase;
48-158 3.05e-21

bifunctional murein DD-endopeptidase/murein LD-carboxypeptidase;


Pssm-ID: 236773 [Multi-domain]  Cd Length: 190  Bit Score: 90.59  E-value: 3.05e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080639   48 GYQYKYGGETpKEGFDPSGLIQYVFSKA-DIHLPRSVNDQYKIGTAVKPENLKPGDILFFKKeGSTGtvpTHDALYIGDG 126
Cdd:PRK10838  79 GVRYRLGGST-KKGIDCSAFVQRTFREQfGLELPRSTYEQQEMGKSVSRSKLRTGDLVLFRA-GSTG---RHVGIYIGNN 153

                         90       100       110
                 ....*....|....*....|....*....|..
gi 16080639  127 QMVHSTQSKGVIITNYkKSSYWSGTYIGARRI 158
Cdd:PRK10838 154 QFVHASTSSGVIISSM-NEPYWKKRYNEARRV 184
PRK13914 PRK13914
invasion associated endopeptidase;
169-260 8.03e-21

invasion associated endopeptidase;


Pssm-ID: 237555 [Multi-domain]  Cd Length: 481  Bit Score: 94.10  E-value: 8.03e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080639  169 VVQEAEKYIGVPYVFGGSTPSEgFDCSGLVQYVFQQAlGIYLPRSAEQQWAVGEKVAPQNIKPGDVVYFSntYKTGISHA 248
Cdd:PRK13914 369 IIAEAQKHLGKAYSWGGNGPTT-FDCSGYTKYVFAKA-GISLPRTSGAQYASTTRISESQAKPGDLVFFD--YGSGISHV 444

                         90
                 ....*....|..
gi 16080639  249 GIYAGAGRFIQA 260
Cdd:PRK13914 445 GIYVGNGQMINA 456
PRK13914 PRK13914
invasion associated endopeptidase;
32-158 5.41e-18

invasion associated endopeptidase;


Pssm-ID: 237555 [Multi-domain]  Cd Length: 481  Bit Score: 85.62  E-value: 5.41e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080639   32 ADTSSELIVSEAKNLLGYQYKYGGETPKEgFDPSGLIQYVFSKADIHLPRSVNDQYKIGTAVKPENLKPGDILFFkkegS 111
Cdd:PRK13914 362 SNSSASAIIAEAQKHLGKAYSWGGNGPTT-FDCSGYTKYVFAKAGISLPRTSGAQYASTTRISESQAKPGDLVFF----D 436

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 16080639  112 TGTVPTHDALYIGDGQMVHStQSKGVIITNYKKSSyWSGTYIGARRI 158
Cdd:PRK13914 437 YGSGISHVGIYVGNGQMINA-QDNGVKYDNIHGSG-WGKYLVGFGRV 481
NlpC_inact_RipD NF033743
NlpC/P60 family peptidoglycan-binding protein RipD; RipD proteins, such as founding member ...
 61-134 5.91e-18

NlpC/P60 family peptidoglycan-binding protein RipD; RipD proteins, such as founding member Rv1566c from Mycobacterium tuberculosis, is a catalytically inactive paralog of the peptidoglycan endopeptidases RipA and RipB. A catalytically important Cys and His pair is replaced by Ala-83 and Ser-132.


Pssm-ID: 468164 [Multi-domain]  Cd Length: 177  Bit Score: 80.89  E-value: 5.91e-18
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 16080639   61 GFDPSGLIQYVFSKADIHLPRSVNDQYKIGTAVKPENLKPGDILFFKKEGsTGTVpthdALYIGDGQMVHSTQS 134
Cdd:NF033743  88 GFDASGLMVYAFAGAGVKLPRSSGEQYKVGQKVLPAQALPGDLIFYGPEG-TQSV----ALFLGNGQMLEATDP 156
PRK13914 PRK13914
invasion associated endopeptidase;
297-403 7.87e-18

invasion associated endopeptidase;


Pssm-ID: 237555 [Multi-domain]  Cd Length: 481  Bit Score: 85.24  E-value: 7.87e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080639  297 IVSEATLYVGEVpYKQGGVTPETgFDTAGFVQYVYQKAaGISLPRYATSQYNAGTKIEKADLKPGDIVFFQSTS--LNPS 374
Cdd:PRK13914 369 IIAEAQKHLGKA-YSWGGNGPTT-FDCSGYTKYVFAKA-GISLPRTSGAQYASTTRISESQAKPGDLVFFDYGSgiSHVG 445

                         90       100
                 ....*....|....*....|....*....
gi 16080639  375 IYIGNGQVVHVTlSNGVTITNMNTSTYWK 403
Cdd:PRK13914 446 IYVGNGQMINAQ-DNGVKYDNIHGSGWGK 473
YycO COG3863
Uncharacterized conserved protein YycO, NlpC/P60 family [Function unknown];
98-208 1.17e-08

Uncharacterized conserved protein YycO, NlpC/P60 family [Function unknown];


Pssm-ID: 443072  Cd Length: 166  Bit Score: 54.23  E-value: 1.17e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080639  98 LKPGDILfFKKEGSTGTVP-THDALYIGDGQMVHSTQSkGVIITNYKKSSYWSGTYIGARRIAADPATADvPVVQEAEKY 176
Cdd:COG3863  28 LQPGDIL-LTKSPSTLSGNhGHAGIYIGDGQVVEAVGD-GVRIIPLETWLDRYDTVAVLRVVKTSEAQRT-AAANYAYSQ 104

                        90       100       110
                ....*....|....*....|....*....|....
gi 16080639 177 IGVPYVFGGSTPS--EGFDCSGLVQYVFQQALGI 208
Cdd:COG3863 105 VGKPYNYNFVKNVddKKFYCSQLVWAAYKDAGGI 138
Peptidase_C92 pfam05708
Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family; Amidase_YiiX is a family of ...
 97-227 1.17e-04

Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family; Amidase_YiiX is a family of permuted papain-like amidases. It has amidase specificity for the amide bond between a lipid and an amino acid (or peptide). From the structure, a tetramer, each monomer is made up of a layered alpha-beta fold with a central, 6-stranded, antiparallel beta-sheet that is protected by helices on either side. The catalytic Cys154 in UniProtKB:Q74NK7, PDB:3kw0, is located on the N-terminus of helix alphaF. The two additional helices located above Cys154 contribute to the formation of the active site, where the lysine ligand is bound.


Pssm-ID: 461720  Cd Length: 164  Bit Score: 42.39  E-value: 1.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080639    97 NLKPGDILFfkkeGSTGTVPT---------HDALYIG-----DGQMVHSTQSKGVIITNYKKssyW--SGTYIGARRIAa 160
Cdd:pfam05708   1 QLPTGDIIF----INSRFSLTnainpseykHVAIYIGrngkeDERYVIEATVNGVRITPLRE---FlaRRGSIKVYRLN- 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080639   161 DPATADV--PVVQEAEKYIGVPYVFGGSTPSEGFDCSGLVQYVFQQALGI------------YLPRSAEQQWAVGEKVAP 226
Cdd:pfam05708  73 DGLTVEQmsRAAEQALRRLGKPYGFGFSWEDDRQYCSKLVADCYQEALGIrvgtykilgkliYSNPDAGLKFWEREGVLP 152


                  .
gi 16080639   227 Q 227
Cdd:pfam05708 153 Q 153
YycO COG3863
Uncharacterized conserved protein YycO, NlpC/P60 family [Function unknown];
229-339 2.87e-03

Uncharacterized conserved protein YycO, NlpC/P60 family [Function unknown];


Pssm-ID: 443072  Cd Length: 166  Bit Score: 38.43  E-value: 2.87e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080639 229 IKPGDVVYFSNTYKTGI--SHAGIYAGAGRFIQASRSEkVTISYLSEDYWKSKMTGIRRFDNLTIPKENPIVSEATLYVG 306
Cdd:COG3863  28 LQPGDILLTKSPSTLSGnhGHAGIYIGDGQVVEAVGDG-VRIIPLETWLDRYDTVAVLRVVKTSEAQRTAAANYAYSQVG 106

                        90       100       110
                ....*....|....*....|....*....|....*
gi 16080639 307 EvPYKQGGVTPET--GFDTAGFVQYVYQKAAGISL 339
Cdd:COG3863 107 K-PYNYNFVKNVDdkKFYCSQLVWAAYKDAGGIDL 140
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH