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Conserved domains on  [gi|16080707|ref|NP_391535|]
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putative integral inner membrane protein [Bacillus subtilis subsp. subtilis str. 168]

Protein Classification

VanZ superfamily protein( domain architecture ID 1903977)

VanZ superfamily protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
VanZ super family cl42358
VanZ-like family protein (function unknown) [Function unknown];
58-133 5.75e-03

VanZ-like family protein (function unknown) [Function unknown];


The actual alignment was detected with superfamily member COG5652:

Pssm-ID: 478153  Cd Length: 128  Bit Score: 34.59  E-value: 5.75e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080707  58 FIQKIGHAFSFFVLTYLLWK--QRGSIRSAAAGSFAFAFFT------EVLQLFF-SRNGCIRDVLIDAVGIGLFYGLYVL 128
Cdd:COG5652  42 GFDKLAHFLAYFILGFLLALalRRSRLRRRRALLLAVLIAVlyaildEIHQSFVpGRSASLADVLADTLGALLGVLLVLL 121


                ....*
gi 16080707 129 AKRRK 133
Cdd:COG5652 122 LLRLR 126
 
Name Accession Description Interval E-value
VanZ COG5652
VanZ-like family protein (function unknown) [Function unknown];
58-133 5.75e-03

VanZ-like family protein (function unknown) [Function unknown];


Pssm-ID: 444373  Cd Length: 128  Bit Score: 34.59  E-value: 5.75e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080707  58 FIQKIGHAFSFFVLTYLLWK--QRGSIRSAAAGSFAFAFFT------EVLQLFF-SRNGCIRDVLIDAVGIGLFYGLYVL 128
Cdd:COG5652  42 GFDKLAHFLAYFILGFLLALalRRSRLRRRRALLLAVLIAVlyaildEIHQSFVpGRSASLADVLADTLGALLGVLLVLL 121


                ....*
gi 16080707 129 AKRRK 133
Cdd:COG5652 122 LLRLR 126
vanZ_1 NF037970
VanZ family protein; VanZ was originally identified in Enterococcus faecium. VanZ increases ...
 27-118 8.91e-03

VanZ family protein; VanZ was originally identified in Enterococcus faecium. VanZ increases teicoplanin resistance in Enterococcus faecium, but has no impact on vancomycin resistance. Proteins of this family are homologs of the VanZ protein. They may be involved in teicoplanin resistance.


Pssm-ID: 468295  Cd Length: 107  Bit Score: 33.73  E-value: 8.91e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080707   27 VSQTVAFHFQPHPDLSQFLVMDFteltvpeaFIQKIGHAFSFFVLTYLLWKQRGSIRSAAAGSFAFAFFT-------EVL 99
Cdd:NF037970  15 ESSSLSPFVQKLKELPKLEFLEF--------FIRKWAHFFAYFILAILLFLALGKFRKKGKSKLLALLLCvlyavsdEFH 86

                         90       100
                 ....*....|....*....|
gi 16080707  100 QLF-FSRNGCIRDVLIDAVG 118
Cdd:NF037970  87 QSFvPGRSPDVRDVLIDSIG 106
 
Name Accession Description Interval E-value
VanZ COG5652
VanZ-like family protein (function unknown) [Function unknown];
58-133 5.75e-03

VanZ-like family protein (function unknown) [Function unknown];


Pssm-ID: 444373  Cd Length: 128  Bit Score: 34.59  E-value: 5.75e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080707  58 FIQKIGHAFSFFVLTYLLWK--QRGSIRSAAAGSFAFAFFT------EVLQLFF-SRNGCIRDVLIDAVGIGLFYGLYVL 128
Cdd:COG5652  42 GFDKLAHFLAYFILGFLLALalRRSRLRRRRALLLAVLIAVlyaildEIHQSFVpGRSASLADVLADTLGALLGVLLVLL 121


                ....*
gi 16080707 129 AKRRK 133
Cdd:COG5652 122 LLRLR 126
vanZ_1 NF037970
VanZ family protein; VanZ was originally identified in Enterococcus faecium. VanZ increases ...
 27-118 8.91e-03

VanZ family protein; VanZ was originally identified in Enterococcus faecium. VanZ increases teicoplanin resistance in Enterococcus faecium, but has no impact on vancomycin resistance. Proteins of this family are homologs of the VanZ protein. They may be involved in teicoplanin resistance.


Pssm-ID: 468295  Cd Length: 107  Bit Score: 33.73  E-value: 8.91e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080707   27 VSQTVAFHFQPHPDLSQFLVMDFteltvpeaFIQKIGHAFSFFVLTYLLWKQRGSIRSAAAGSFAFAFFT-------EVL 99
Cdd:NF037970  15 ESSSLSPFVQKLKELPKLEFLEF--------FIRKWAHFFAYFILAILLFLALGKFRKKGKSKLLALLLCvlyavsdEFH 86

                         90       100
                 ....*....|....*....|
gi 16080707  100 QLF-FSRNGCIRDVLIDAVG 118
Cdd:NF037970  87 QSFvPGRSPDVRDVLIDSIG 106
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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