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Conserved domains on  [gi|16080746|ref|NP_391574|]
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protein-arginine(tyrosine moonlighting) phosphatase (oxidative stress) [Bacillus subtilis subsp. subtilis str. 168]

Protein Classification

low molecular weight protein arginine phosphatase( domain architecture ID 11611418)

low molecular weight protein arginine phosphatase is a member of the low molecular weight phosphatase (LMWP) family, sharing a highly conserved active site motif (V/I)CXGNTCRS; it has been shown that the conserved threonine, which is an isoleucine in many LMWPTPs, confers specificity to phosphoarginine over phosphotyrosine; similar to Bacillus subtilis YwlE which catalyzes the specific dephosphorylation of phosphoarginine residues in a large number of proteins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LMWPAP cd16344
low molecular weight protein arginine phosphatase; Low molecular weight protein arginine ...
 1-143 2.68e-82

low molecular weight protein arginine phosphatase; Low molecular weight protein arginine phosphatases are part of the low molecular weight phosphatase (LMWP) family. They share a highly conserved active site motif (V/I)CXGNTCRS. It has been shown that the conserved threonine, which in many LMWPTPs is an isoleucine, confers specificity to phosphoarginine over phosphotyrosine.


:

Pssm-ID: 319972  Cd Length: 142  Bit Score: 238.49  E-value: 2.68e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080746   1 MDIIFVCTGNTCRSPMAEALFKSIAEREglNVNVRSAGVFASPNGKATPHAVEALFEKHIAL-NHVSSPLTEELMESADL 79
Cdd:cd16344   1 MKILFVCTGNTCRSPMAEAILKKLLEEL--DVEVKSAGIFAVDGSPASPNAVEVLKEKGIDLsGHRSQQLTEELLEWADL 78

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 16080746  80 VLAMTHQHKQIIASQFGRYRDKVFTLKEYVTGSHGDVLDPFGGSIDIYKQTRDELEELLRQLAK 143
Cdd:cd16344  79 ILTMTESHKQALLSLYPEAADKVFTLKEYVGGEDGDISDPFGGSLEVYRQTAEELEELIEKLLK 142
 
Name Accession Description Interval E-value
LMWPAP cd16344
low molecular weight protein arginine phosphatase; Low molecular weight protein arginine ...
 1-143 2.68e-82

low molecular weight protein arginine phosphatase; Low molecular weight protein arginine phosphatases are part of the low molecular weight phosphatase (LMWP) family. They share a highly conserved active site motif (V/I)CXGNTCRS. It has been shown that the conserved threonine, which in many LMWPTPs is an isoleucine, confers specificity to phosphoarginine over phosphotyrosine.


Pssm-ID: 319972  Cd Length: 142  Bit Score: 238.49  E-value: 2.68e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080746   1 MDIIFVCTGNTCRSPMAEALFKSIAEREglNVNVRSAGVFASPNGKATPHAVEALFEKHIAL-NHVSSPLTEELMESADL 79
Cdd:cd16344   1 MKILFVCTGNTCRSPMAEAILKKLLEEL--DVEVKSAGIFAVDGSPASPNAVEVLKEKGIDLsGHRSQQLTEELLEWADL 78

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 16080746  80 VLAMTHQHKQIIASQFGRYRDKVFTLKEYVTGSHGDVLDPFGGSIDIYKQTRDELEELLRQLAK 143
Cdd:cd16344  79 ILTMTESHKQALLSLYPEAADKVFTLKEYVGGEDGDISDPFGGSLEVYRQTAEELEELIEKLLK 142
LMWPc smart00226
Low molecular weight phosphatase family;
3-144 3.74e-65

Low molecular weight phosphatase family;


Pssm-ID: 197586  Cd Length: 134  Bit Score: 195.00  E-value: 3.74e-65
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080746      3 IIFVCTGNTCRSPMAEALFKSIAereGLNVNVRSAGVFASPNGKATPHAVEALFEKHIALNHVSSPLTEELMESADLVLA 82
Cdd:smart00226   1 ILFVCTGNICRSPMAEALFKAYV---GDRVKIDSAGTGAWVGGGADPRAVKVLKEHGIDLSHHASQLTSSDFKNADLVLA 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 16080746     83 MTHQHKQIIASQFGRYRDKVFTLKEYVtgshgDVLDPFGGSIDIYKQTRDELEELLRQLAKQ 144
Cdd:smart00226  78 MDGSHLRNICRLKPPSRAKVELFGHYV-----DVDDPYYGGIDGFERVYDELENALQEFLKQ 134
LMWPc pfam01451
Low molecular weight phosphotyrosine protein phosphatase;
3-142 3.10e-55

Low molecular weight phosphotyrosine protein phosphatase;


Pssm-ID: 460216  Cd Length: 142  Bit Score: 169.86  E-value: 3.10e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080746     3 IIFVCTGNTCRSPMAEALFKSIAEREGLN--VNVRSAGVFASPNGKATPHAVEALFEKHIALN-HVSSPLTEELMESADL 79
Cdd:pfam01451   1 ILFVCTGNICRSPMAEAIFRRELEKAGLGdkVEVDSAGTGAWPGNPADPRAVEVLKEHGIDLSgHYARQLSTEDFASFDL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 16080746    80 VLAMTHQHKQIIASQF-GRYRDKVFTLKEYvtGSHGDVLDPFGGSIDIYKQTRDELEELLRQLA 142
Cdd:pfam01451  81 ILAMDSEHKRDLCPLApERYRAKVMLLGEY--GEQLDIPDPYYGSIDAFEEVRDLIERRCRQLL 142
Wzb COG0394
Protein-tyrosine-phosphatase [Signal transduction mechanisms];
3-147 2.41e-40

Protein-tyrosine-phosphatase [Signal transduction mechanisms];


Pssm-ID: 440163  Cd Length: 137  Bit Score: 131.82  E-value: 2.41e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080746   3 IIFVCTGNTCRSPMAEALFKSIAEREglnVNVRSAGVfaSPNGKATPHAVEALFEKHIAL-NHVSSPLTEELMESADLVL 81
Cdd:COG0394   6 VLFVCTGNICRSPMAEALLRHLAGGR---VEVDSAGT--EPGGPVDPRAVAVLAERGIDLsGHRSRQLDEEDLPEFDLVI 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 16080746  82 AMTHQHKQIIASQFGRYRDKVftlkeyvtgSHGDVLDPFGGSIDIYKQTRDELEELLRQLAKQLKK 147
Cdd:COG0394  81 TMCDSAAEELCPLFPGAAKLL---------LHWDVPDPYYGGLEAFREVRDEIERRIEALLAKLRR 137
etp PRK11391
phosphotyrosine-protein phosphatase; Provisional
 3-147 4.33e-16

phosphotyrosine-protein phosphatase; Provisional


Pssm-ID: 138553  Cd Length: 144  Bit Score: 70.05  E-value: 4.33e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080746    3 IIFVCTGNTCRSPMAEALFKsiaeREGLNVNVRSAGVFASPNGKATPHAVEALFEKHIALN-HVSSPLTEELMESADLVL 81
Cdd:PRK11391   5 ILVVCTGNICRSPIGERLLR----KRLPGVKVKSAGVHGLVKHPADATAADVAANHGVSLEgHAGRKLTAEMARNYDLIL 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 16080746   82 AMTHQHKQIIASQFGRYRDKVFTLKEYVtgSHGDVLDPFGGSIDIYKQTRDELEELLRQLAKQLKK 147
Cdd:PRK11391  81 AMESEHIAQVTAIAPEVRGKTMLFGQWL--EQKEIPDPYRKSQDAFEHVYGMLERASQEWAKRLSR 144
arsC_pI258_fam TIGR02691
arsenate reductase (thioredoxin); This family describes the well-studied thioredoxin-dependent ...
 3-141 1.25e-14

arsenate reductase (thioredoxin); This family describes the well-studied thioredoxin-dependent arsenate reductase of Staphylococcus aureaus plasmid pI258 and other mechanistically similar arsenate reductases. The mechanism involves an intramolecular disulfide bond cascade, and aligned members of this family have four absolutely conserved Cys residues. This group of arsenate reductases belongs to the low-molecular weight protein-tyrosine phosphatase family (pfam01451), as does a group of glutathione/glutaredoxin type arsenate reductases (TIGR02689). At least two other, non-homologous groups of arsenate reductases involved in arsenical resistance are also known. This enzyme reduces arsenate to arsenite, which may be more toxic but which is more easily exported. [Cellular processes, Detoxification]


Pssm-ID: 131738  Cd Length: 129  Bit Score: 65.96  E-value: 1.25e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080746     3 IIFVCTGNTCRSPMAEALFKSIAereGLNVNVRSAGVFASpngKATPHAVEALFEKHIAL-NHVSSPLTEELMESADLVL 81
Cdd:TIGR02691   1 IYFLCTGNSCRSQMAEGWGKKYL---GDEWEVYSAGIEAH---GLNPNAVKAMKEVGIDIsNQTSDLIDLDILNKADLVV 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 16080746    82 AMThqhkqiiasqfGRYRDKVFTLKEYVTGSHGDVLDPFG--GSID----IYKQTRDELEELLRQL 141
Cdd:TIGR02691  75 TLC-----------GDARDKCPATPPHVKREHWGLDDPARaeGTEEekwaVFRRVRDEIKERVKDF 129
 
Name Accession Description Interval E-value
LMWPAP cd16344
low molecular weight protein arginine phosphatase; Low molecular weight protein arginine ...
 1-143 2.68e-82

low molecular weight protein arginine phosphatase; Low molecular weight protein arginine phosphatases are part of the low molecular weight phosphatase (LMWP) family. They share a highly conserved active site motif (V/I)CXGNTCRS. It has been shown that the conserved threonine, which in many LMWPTPs is an isoleucine, confers specificity to phosphoarginine over phosphotyrosine.


Pssm-ID: 319972  Cd Length: 142  Bit Score: 238.49  E-value: 2.68e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080746   1 MDIIFVCTGNTCRSPMAEALFKSIAEREglNVNVRSAGVFASPNGKATPHAVEALFEKHIAL-NHVSSPLTEELMESADL 79
Cdd:cd16344   1 MKILFVCTGNTCRSPMAEAILKKLLEEL--DVEVKSAGIFAVDGSPASPNAVEVLKEKGIDLsGHRSQQLTEELLEWADL 78

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 16080746  80 VLAMTHQHKQIIASQFGRYRDKVFTLKEYVTGSHGDVLDPFGGSIDIYKQTRDELEELLRQLAK 143
Cdd:cd16344  79 ILTMTESHKQALLSLYPEAADKVFTLKEYVGGEDGDISDPFGGSLEVYRQTAEELEELIEKLLK 142
LMWPc smart00226
Low molecular weight phosphatase family;
3-144 3.74e-65

Low molecular weight phosphatase family;


Pssm-ID: 197586  Cd Length: 134  Bit Score: 195.00  E-value: 3.74e-65
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080746      3 IIFVCTGNTCRSPMAEALFKSIAereGLNVNVRSAGVFASPNGKATPHAVEALFEKHIALNHVSSPLTEELMESADLVLA 82
Cdd:smart00226   1 ILFVCTGNICRSPMAEALFKAYV---GDRVKIDSAGTGAWVGGGADPRAVKVLKEHGIDLSHHASQLTSSDFKNADLVLA 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 16080746     83 MTHQHKQIIASQFGRYRDKVFTLKEYVtgshgDVLDPFGGSIDIYKQTRDELEELLRQLAKQ 144
Cdd:smart00226  78 MDGSHLRNICRLKPPSRAKVELFGHYV-----DVDDPYYGGIDGFERVYDELENALQEFLKQ 134
LMWPc pfam01451
Low molecular weight phosphotyrosine protein phosphatase;
3-142 3.10e-55

Low molecular weight phosphotyrosine protein phosphatase;


Pssm-ID: 460216  Cd Length: 142  Bit Score: 169.86  E-value: 3.10e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080746     3 IIFVCTGNTCRSPMAEALFKSIAEREGLN--VNVRSAGVFASPNGKATPHAVEALFEKHIALN-HVSSPLTEELMESADL 79
Cdd:pfam01451   1 ILFVCTGNICRSPMAEAIFRRELEKAGLGdkVEVDSAGTGAWPGNPADPRAVEVLKEHGIDLSgHYARQLSTEDFASFDL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 16080746    80 VLAMTHQHKQIIASQF-GRYRDKVFTLKEYvtGSHGDVLDPFGGSIDIYKQTRDELEELLRQLA 142
Cdd:pfam01451  81 ILAMDSEHKRDLCPLApERYRAKVMLLGEY--GEQLDIPDPYYGSIDAFEEVRDLIERRCRQLL 142
Wzb COG0394
Protein-tyrosine-phosphatase [Signal transduction mechanisms];
3-147 2.41e-40

Protein-tyrosine-phosphatase [Signal transduction mechanisms];


Pssm-ID: 440163  Cd Length: 137  Bit Score: 131.82  E-value: 2.41e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080746   3 IIFVCTGNTCRSPMAEALFKSIAEREglnVNVRSAGVfaSPNGKATPHAVEALFEKHIAL-NHVSSPLTEELMESADLVL 81
Cdd:COG0394   6 VLFVCTGNICRSPMAEALLRHLAGGR---VEVDSAGT--EPGGPVDPRAVAVLAERGIDLsGHRSRQLDEEDLPEFDLVI 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 16080746  82 AMTHQHKQIIASQFGRYRDKVftlkeyvtgSHGDVLDPFGGSIDIYKQTRDELEELLRQLAKQLKK 147
Cdd:COG0394  81 TMCDSAAEELCPLFPGAAKLL---------LHWDVPDPYYGGLEAFREVRDEIERRIEALLAKLRR 137
LMWP cd00115
Low molecular weight phosphatase family; Low molecular weight phosphatases (LMWPs) are a group ...
 3-143 1.21e-36

Low molecular weight phosphatase family; Low molecular weight phosphatases (LMWPs) are a group of small soluble enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). This family includes protein tyrosine phosphatases, arginine phosphatases and arsenate reductases.


Pssm-ID: 319970  Cd Length: 137  Bit Score: 122.60  E-value: 1.21e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080746   3 IIFVCTGNTCRSPMAEALFKSIAEREglnVNVRSAGVFASPNGKATPHAVEALFEKHIALNHVSSPLTEELMESADLVLA 82
Cdd:cd00115   2 ILFICTGNICRSPMAEAIFKQLLGDE---WKVDSAGTGAHHGEGADPRAVRVLKEVGIDISHRSDQIKSEHLDNYDLVLV 78

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 16080746  83 MTHQHKQIIASQFGRYRDKvfTLKEYVTGSHGDVLDPFGGSIDIYKQTRDELEELLRQLAK 143
Cdd:cd00115  79 MDGSNLDKIPRIFPEARGK--TWLPHVKLEHGEIDDPYRGDIEDFRRVRDELENASKRFAE 137
LMWPTP cd16343
Low molecular weight protein tyrosine phosphatase; Low molecular weight protein tyrosine ...
 1-143 3.21e-36

Low molecular weight protein tyrosine phosphatase; Low molecular weight protein tyrosine phosphatases (LMW-PTP) are a family of small soluble single-domain enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). LMW-PTPs play important roles in many biological processes and are widely distributed in prokaryotes and eukaryotes.


Pssm-ID: 319971  Cd Length: 147  Bit Score: 121.78  E-value: 3.21e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080746   1 MDIIFVCTGNTCRSPMAEALFKS-IAEREGLNVNVRSAGVFASPNGK-ATPHAVEALFEKHIALN-HVSSPLTEELMESA 77
Cdd:cd16343   1 KKILFVCLGNICRSPMAEAVLRHlLPKAGGDDVEVDSAGTSAWHGGEpPDPRARAVLKEHGIDLSgHRARQLTAEDFDEF 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 16080746  78 DLVLAMTHQHKQIIASQFGR-YRDKVFTLKEYVTGSHGDVLDPFGGSIDIYKQTRDELEELLRQLAK 143
Cdd:cd16343  81 DLILAMDESNLRDLRRLAPAeARGKVFLLGDFDPEGGKDVPDPYYGGREGFEEVYDLIERACEGLLE 147
etp PRK11391
phosphotyrosine-protein phosphatase; Provisional
 3-147 4.33e-16

phosphotyrosine-protein phosphatase; Provisional


Pssm-ID: 138553  Cd Length: 144  Bit Score: 70.05  E-value: 4.33e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080746    3 IIFVCTGNTCRSPMAEALFKsiaeREGLNVNVRSAGVFASPNGKATPHAVEALFEKHIALN-HVSSPLTEELMESADLVL 81
Cdd:PRK11391   5 ILVVCTGNICRSPIGERLLR----KRLPGVKVKSAGVHGLVKHPADATAADVAANHGVSLEgHAGRKLTAEMARNYDLIL 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 16080746   82 AMTHQHKQIIASQFGRYRDKVFTLKEYVtgSHGDVLDPFGGSIDIYKQTRDELEELLRQLAKQLKK 147
Cdd:PRK11391  81 AMESEHIAQVTAIAPEVRGKTMLFGQWL--EQKEIPDPYRKSQDAFEHVYGMLERASQEWAKRLSR 144
LMWP_ArsC cd16345
Arsenate reductase of the LMWP family; Arsenate reductase plays an important role in the ...
 3-83 1.76e-15

Arsenate reductase of the LMWP family; Arsenate reductase plays an important role in the reduction of intracellular arsenate to arsenite, an important step in arsenic detoxification. The reduction involves three different thiolate nucleophiles. In arsenate reductases of the LMWP family, reduction can be coupled with thioredoxin (Trx)/thioredoxin reductase (TrxR) or glutathione (GSH)/glutaredoxin (Grx).


Pssm-ID: 319973  Cd Length: 132  Bit Score: 68.24  E-value: 1.76e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080746   3 IIFVCTGNTCRSPMAEALFKSIAereGLNVNVRSAGVFAS-PNgkatPHAVEALFEKHIAL-NHVSSPLTEELMESADLV 80
Cdd:cd16345   2 VLFLCTGNSARSQMAEALLRHLG---GDRFEAYSAGSEPAgVN----PLAIEVMKEIGIDIsGQRSKSLDEFLGQEFDYV 74


                ...
gi 16080746  81 LAM 83
Cdd:cd16345  75 ITV 77
arsC_pI258_fam TIGR02691
arsenate reductase (thioredoxin); This family describes the well-studied thioredoxin-dependent ...
 3-141 1.25e-14

arsenate reductase (thioredoxin); This family describes the well-studied thioredoxin-dependent arsenate reductase of Staphylococcus aureaus plasmid pI258 and other mechanistically similar arsenate reductases. The mechanism involves an intramolecular disulfide bond cascade, and aligned members of this family have four absolutely conserved Cys residues. This group of arsenate reductases belongs to the low-molecular weight protein-tyrosine phosphatase family (pfam01451), as does a group of glutathione/glutaredoxin type arsenate reductases (TIGR02689). At least two other, non-homologous groups of arsenate reductases involved in arsenical resistance are also known. This enzyme reduces arsenate to arsenite, which may be more toxic but which is more easily exported. [Cellular processes, Detoxification]


Pssm-ID: 131738  Cd Length: 129  Bit Score: 65.96  E-value: 1.25e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080746     3 IIFVCTGNTCRSPMAEALFKSIAereGLNVNVRSAGVFASpngKATPHAVEALFEKHIAL-NHVSSPLTEELMESADLVL 81
Cdd:TIGR02691   1 IYFLCTGNSCRSQMAEGWGKKYL---GDEWEVYSAGIEAH---GLNPNAVKAMKEVGIDIsNQTSDLIDLDILNKADLVV 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 16080746    82 AMThqhkqiiasqfGRYRDKVFTLKEYVTGSHGDVLDPFG--GSID----IYKQTRDELEELLRQL 141
Cdd:TIGR02691  75 TLC-----------GDARDKCPATPPHVKREHWGLDDPARaeGTEEekwaVFRRVRDEIKERVKDF 129
PRK13530 PRK13530
arsenate reductase (thioredoxin);
3-146 2.73e-14

arsenate reductase (thioredoxin);


Pssm-ID: 237415  Cd Length: 133  Bit Score: 65.15  E-value: 2.73e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080746    3 IIFVCTGNTCRSPMAEALFKSIAereGLNVNVRSAGVFASpngKATPHAVEALFEKHIAL-NHVSSPLTEELMESADLVL 81
Cdd:PRK13530   6 IYFLCTGNSCRSQMAEGWGKQYL---GDKWNVYSAGIEAH---GVNPNAIKAMKEVGIDIsNQTSDIIDNDILNNADLVV 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 16080746   82 AMThqhkqiiasqfGRYRDKVFTLKEYVTGSHGDVLDPFGGSIDIYKQTRDELEELLRQLAKQLK 146
Cdd:PRK13530  80 TLC-----------SHADDVCPSTPPHVKRVHWGFDDPAGKEWSEFQRVRDEIGERIKRFAETGE 133
COG4551 COG4551
Predicted protein tyrosine phosphatase [General function prediction only];
1-98 8.54e-14

Predicted protein tyrosine phosphatase [General function prediction only];


Pssm-ID: 443615  Cd Length: 109  Bit Score: 63.31  E-value: 8.54e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080746   1 MDIIFVCTGNTCRSPMAEALFksiAEREGlnVNVRSAGVfaspngkaTPHAVEalfekhialnhvssPLTEELMESADLV 80
Cdd:COG4551   2 MNVLFVCSRNRWRSPTAEQVF---RNHPG--VEVRSAGT--------SPDARV--------------PVTAELIEWADVI 54

                        90
                ....*....|....*...
gi 16080746  81 LAMTHQHKQIIASQFGRY 98
Cdd:COG4551  55 FVMEKKHRNRLSKRFGRL 72
PRK10126 PRK10126
low molecular weight protein-tyrosine-phosphatase Wzb;
3-149 7.90e-13

low molecular weight protein-tyrosine-phosphatase Wzb;


Pssm-ID: 182256  Cd Length: 147  Bit Score: 61.85  E-value: 7.90e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080746    3 IIFVCTGNTCRSPMAEALFKsiaeREGLNVNVRSAGVFASPNGKATPHAVEALFEKHIAL-NHVSSPLTEELMESADLVL 81
Cdd:PRK10126   5 ILVVCVGNICRSPTAERLLQ----RYHPELKVESAGLGALVGKGADPTAISVAAEHQLSLeGHCARQISRRLCRNYDLIL 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 16080746   82 AMTHQHKQIIASQFGRYRDKVFTLKEYvtGSHGDVLDPFGGSIDIYKQTRDELEELLRQLAKQLKKDR 149
Cdd:PRK10126  81 TMEKRHIERLCEMAPEMRGKVMLFGHW--DNECEIPDPYRKSREAFEAVYTLLERSARQWAQALNAEQ 146
ars_reduc_gluta TIGR02689
arsenate reductase, glutathione/glutaredoxin type; Members of this protein family represent a ...
 3-141 1.72e-07

arsenate reductase, glutathione/glutaredoxin type; Members of this protein family represent a novel form of arsenate reductase, using glutathione and glutaredoxin rather than thioredoxin for reducing equivalents as do some homologous arsenate reductases. An example of this type is Synechocystis sp. strain PCC 6803 slr0946, and of latter type (excluded from this model) is Staphylococcus aureus plasmid pI258 ArsC. Both are among the subset of arsenate reductases that belong the the low-molecular-weight protein-tyrosine phosphatase superfamily. [Cellular processes, Detoxification]


Pssm-ID: 131736  Cd Length: 126  Bit Score: 47.20  E-value: 1.72e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080746     3 IIFVCTGNTCRSPMAEALFKSIAEReglNVNVRSAGVFASpngKATPHAVEALFEKHIAL-NHVSSPLTEELMESADLVL 81
Cdd:TIGR02689   3 VMFVCKRNSCRSQMAEGFAKTLGAG---KIAVTSCGLESS---RVHPTAIAVMEEVGIDIsGQTSKPLENFNAEDYDVVI 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080746    82 AMthqhkqiiaSQFGRYRDKVFTLKEYVTGSHGDvlDPFGGSIDIYKQTRDELEELLRQL 141
Cdd:TIGR02689  77 SL---------CGCGVNLPEAWVTREIFEDWQLE--DPDGQSLEVFRRVRDEIKERVENL 125
TRX_Fd_family cd02980
Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX ...
 3-59 9.91e-04

Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:ubiquinone oxidoreductase (NuoE). TRX-like Fds are soluble low-potential electron carriers containing a single [2Fe-2S] cluster. The exact role of TRX-like Fd is still unclear. It has been suggested that it may be involved in nitrogen fixation. Its homologous domains in large redox enzymes (such as Nuo and hydrogenases) function as electron carriers.


Pssm-ID: 239278 [Multi-domain]  Cd Length: 77  Bit Score: 36.07  E-value: 9.91e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 16080746   3 IIFVCTGNTCRS----PMAEALFKSIAEREG-LNVNVRSAG-----VFAsPN----------GKATPHAVEALFEKH 59
Cdd:cd02980   2 HILVCTGTACGLrgaeELLEALEKELGIRGGdGRVTVERVGclgacGLA-PVvvvypdgvwyGRVTPEDVEEIVEEL 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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