|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC18B1 |
cd17385 |
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ... |
37-426 |
0e+00 |
|
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340943 [Multi-domain] Cd Length: 390 Bit Score: 554.14 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 37 LISAASVNLGSMMCYSILGPFFPKEAEKKGASNTIIGMIFGCFALFELLASLVFGNYLVHIGAKFMFVAGMFVSGGVTIL 116
Cdd:cd17385 1 LISLALANFSSMICYSILAPFFPREAEKKGVSDTIIGLVFGCFALVIFLTSPIFGKYLVKIGAKFMFVAGMFVSGGCTIL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 117 FGVLDRVPDGPVFIAMCFLVRVMDAVSFAAAMTASSSILAKAFPNNVATVLGSLETFSGLGLILGPPVGGFLYQSFGYEV 196
Cdd:cd17385 81 FGFLDRVPDGTVFIALCFLVRIVEAVGFAAFITASFAIIAKEFPNNIATVLGTLETFSGLGLMLGPPLGGFLYQAGGYEL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 197 PFIVLGCVVLLMVPLNMYILPNYESDPGEH--SFWKLIALPKVGLIAFVINSLSSCFGFLDPTLSLFvLEKFNLPAGYVG 274
Cdd:cd17385 161 PFLVLGCLLLLTVPLNMFILPRYDDDPSPKsgSMLKLLKIPSVLLLCLSIVSGSVSLGFLDPTLSPH-LRQFKLSPGQVG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 275 LVFLGMALSYAISSPLFGLLSDKRpPLRKWLLVFGNLITAGCYMLLGPVPILHIKSQLWLLVLILVVSGLSAGMSIIPTF 354
Cdd:cd17385 240 LMFLILAGSYAISAPLWGWLSDKK-KIPKWLMVIGSIITGVGFLLLGPAPLLPIKSELWMVIIGLVLLGLSLGAALVPTF 318
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 16445357 355 PEILSCAHENGFEEGLSTLGLVSGLFSAMWSIGAFMGPTLGGFLYEKIGFEWAAAIQGLWALISGLAMGLFY 426
Cdd:cd17385 319 PELLNCAREYGFPDNLSTYGLVSGLFNAAFSLGAFIGPTLGGFLLERLGFEWAATIQAGLAFVVGILMSIYY 390
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
41-426 |
1.05e-56 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 192.02 E-value: 1.05e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 41 ASVNLGSMMCYSILGPFFPKEAEKKGASNTIIGMIFGCFALFELLASLVFGNYLVHIGAKFMFVAGMFVSGGVTILFGVL 120
Cdd:cd17325 2 SLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 121 DrvpdgpvFIAMCFLVRVMDAVSFAAAMTASSSILAKAFP-NNVATVLGSLETFSGLGLILGPPVGGFLYQSFGYEVPFI 199
Cdd:cd17325 82 T-------SYWQLLLARFLQGLASAAVWPAAMALIADIAPpEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 200 VLGCVVLLMVPLNMYILPNYE---------SDPGEHSFWKLIALPKVGLIAFVINSLSSCFGFLDPTLSLFVLEKFNLPA 270
Cdd:cd17325 155 VCAALALLALVLALLLLPEPRpppnkravsAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSP 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 271 GYVGLVFLGMALSYAISSPLFGLLSDKRPplRKWLLVFGNLITAGCYMLLGPVPILHIksqlwlLVLILVVSGLSAGMSI 350
Cdd:cd17325 235 AQIGLLFGAQGLASALSQPPAGKLSDRIG--RKPLILIGLLLSAVALLLLPLATSFWL------LLLLLALLGLGLGLVF 306
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 16445357 351 IPTFPEILSCAHENGfeeglstLGLVSGLFSAMWSIGAFMGPTLGGFLYEKIGFEWAAAIQGLWALISGLAMGLFY 426
Cdd:cd17325 307 PATLALLADIVPPEG-------RGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
30-425 |
6.95e-25 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 105.34 E-value: 6.95e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 30 SREQVFVLISAASVNLGSMMCYSILGPFFPKEAEKKGASNTIIGMIFGCFALFELLASLVFGNYLVHIGAKFMFVAGMFV 109
Cdd:COG2271 5 SRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 110 SGGVTILFGVldrVPDGPVFIAMCFLVrvmdAVSFAAAMTASSSILAKAFPNNV-ATVLGSLETFSGLGLILGPPVGGFL 188
Cdd:COG2271 85 WGLATLLFGF---ATSFWQLLLLRFLL----GLGEAGFFPAALKLIAEWFPPKErGRALGIFNAGGPLGGALAPPLLGWL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 189 YQSFGYEVPFIVLGCVVLLMVPLNMYILpnyesdpgehsfwklialpkvGLIAFVINSLSSCFGFLdptLSLFVLEKFNL 268
Cdd:COG2271 158 LAAFGWRAAFLILGLPGLLLALLRFWLL---------------------ALAYFLVYFALYGFLTW---LPTYLVEVRGL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 269 PAGYVGLVFLGMALSYAISSPLFGLLSDKRPPLRKWLLVFGNLITAGCYMLLGPVPILHIksqlwllvliLVVSGLSAGM 348
Cdd:COG2271 214 SLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPAL----------AIALLFLAGF 283
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 16445357 349 SIIPTFPEILSCAHENGfeeGLSTLGLVSGLFSAMWSIGAFMGPTLGGFLYEKIGFEWAAAIQGLWALISGLAMGLF 425
Cdd:COG2271 284 GLGGAFGLLWALAAELF---PKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLL 357
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
30-324 |
1.26e-24 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 104.29 E-value: 1.26e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 30 SREQVFVLISAASVNLGSMMCYSILGPFFPKEAEKKGASNTIIGMIFGCFALFELLASLVFGNYLVHIGAKFMFVAGMFV 109
Cdd:COG2814 5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 110 SGGVTILFGVldrVPDGPVFIAMcflvRVMDAVSFAAAMTASSSILAKAFP-NNVATVLGSLETFSGLGLILGPPVGGFL 188
Cdd:COG2814 85 FALGSLLCAL---APSLWLLLAA----RFLQGLGAGALFPAALALIADLVPpERRGRALGLLGAGLGLGPALGPLLGGLL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 189 YQSFGYEVPFIVLGCVVLLMVPLNMYILPNY---ESDPGEHSFWKLIALPKVGLIAFVINSLSSCFGFLDPTLSLFVLEK 265
Cdd:COG2814 158 ADLFGWRWVFLVNAVLALLALLLLLRLLPESrpaARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEV 237
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 16445357 266 FNLPAGYVGLVFLGMALSYAISSPLFGLLSDKRPplRKWLLVFGNLITAGCYMLLGPVP 324
Cdd:COG2814 238 LGLSASAAGLLLALFGLGGVLGALLAGRLADRFG--RRRLLLIGLLLLALGLLLLALAG 294
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
41-392 |
4.91e-20 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 90.94 E-value: 4.91e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 41 ASVNLGSMMCYSILGPFFPKE-AEKKGASNTIIGMIFGCFALFELLASLVFGNYLVHIGAKFMFVAGMFVSGGVTILFGV 119
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLlAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 120 LDRVPdgpvfiaMCFLVRVMDAVSFAAAMTASSSILAKAFP-NNVATVLGSLETFSGLGLILGPPVGGFLYQSFGYEVPF 198
Cdd:pfam07690 82 ASSLW-------LLLVLRVLQGLGAGALFPAALALIADWFPpEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAF 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 199 IVLGCVVLLMVPLNMYILPNYESDP---------GEHSFWKLIALPKVGLIAFVINSLSSCFGFLDPTLSLFVlEKFNLP 269
Cdd:pfam07690 155 LILAILSLLAAVLLLLPRPPPESKRpkpaeearlSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQ-EVLGLS 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 270 AGYVGLVFLGMALSYAISSPLFGLLSDKRPPLRKWLLVFGNLITAGCYMLLGPVPilhiksqlwLLVLILVVSGLSAGMS 349
Cdd:pfam07690 234 ALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLT---------LSSLWLLLALLLLGFG 304
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 16445357 350 IIPTFPEILSCAHENGFEEglsTLGLVSGLFSAMWSIGAFMGP 392
Cdd:pfam07690 305 FGLVFPALNALVSDLAPKE---ERGTASGLYNTAGSLGGALGP 344
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
36-426 |
1.05e-19 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 90.71 E-value: 1.05e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 36 VLISAASVNLGSMMCYSILGPFFPKEAEKKGASNTIIGMIFGCFALFELLASLVFGNYLVHIGAKFMFVAGMFVSGGVTI 115
Cdd:COG2223 6 VLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 116 LFGVldrVPDGPVFIAMCFLVRVMDAVSFAAAMtassSILAKAFP-NNVATVLGSLETFSGLGLILGPPVGGFLYQSFGY 194
Cdd:COG2223 86 LLAL---AVSYWLLLLLGLLLGIGGGGSFAVGI----ALVSKWFPpDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGW 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 195 EVPFIVLGCVVLLMVPLNMYILPNYESDPGE------HSFWKLIALPKVGLIAFVINSLSSCFGFLDPTLSLFVLEKFNL 268
Cdd:COG2223 159 RNAFLILGILLLVVAVLAWLFLRDPPAGAAAaakaslRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 269 PAGYVGLVFLGMALSYAISSPLFGLLSDKRPPlRKWLLVFGNLITAGCYMLLGPVPilhiksQLWLLVLILVVSGLSAGM 348
Cdd:COG2223 239 SAATAGLLAALFALLGALGRPLGGWLSDRIGG-RRVLLIVFALMALGLLLLALALG------SLWLFLVLFLLLGLALGG 311
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 16445357 349 SIIPTFPEIlscahenGFEEGLSTLGLVSGLFSAMWSIGAFMGPTLGGFLYEKIG-FEWAAAIQGLWALISGLAMGLFY 426
Cdd:COG2223 312 GNGAVFALV-------PDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVLTLLLY 383
|
|
| MFS_SLC18A1_2_VAT1_2 |
cd17384 |
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ... |
69-322 |
8.75e-19 |
|
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340942 [Multi-domain] Cd Length: 373 Bit Score: 87.63 E-value: 8.75e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 69 NTIIGMIFGCFALFELLASLVFGNYLVHIGAKFMFVAG---MFVSggvTILFGVldrvpdGPVFIAMcFLVRVMDAVSFA 145
Cdd:cd17384 30 NVRVGLLFASKALVQLITNPIVGPLTNRIGYSLPMFVGfviMFIS---TLLFAF------GESYGVL-FLARALQGVGSA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 146 AAMTASSSILAKAFPNN------VATVLGSLetfsGLGLILGPPVGGFLYQSFGYEVPFIVLGCVVLLMVPLNMYIL-PN 218
Cdd:cd17384 100 CSSVAGMGMLASLYPDDkergkaMGIALGGL----ALGVLVGPPFGGVMYEFVGKSAPFLILAFLALLDGALQLFILqPS 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 219 YESDPGEH--SFWKLIALPKVGLIAFVINSLSSCFGFLDPTLSLFVLEKFNLPAGYVGLVFLGMALSYAISSPLFGLLSD 296
Cdd:cd17384 176 VKSEESEEgtPWKTLLKDPYILIAAGAICFSNSGIAILEPCLPIWMMETMCPPKWQLGTAFLPDSIGYLIGTNLFGPLAH 255
|
250 260
....*....|....*....|....*.
gi 16445357 297 KrppLRKWLLVFGNLITAGCYMLLGP 322
Cdd:cd17384 256 K---IGRWLCSLLGMLLVGISLILIP 278
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
43-427 |
2.27e-18 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 86.11 E-value: 2.27e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 43 VNLGSMMCYSILGPFFPKEAEKKGASNTIIGMIFGCFALFELLASLVFGNYLVHIGAKFMFVAGMFVSGGVTILFGVLDR 122
Cdd:cd17489 4 ANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 123 vpdgpvfIAMCFLVRVMDAVSFAAAMTASSSILAKAFPN-NVATVLGSLETFSGLGLILGPPVGGFLYQSFGYEVPFIVL 201
Cdd:cd17489 84 -------VALLLVLRLIHGIGWGAFTTAAATLVADIIPPsRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 202 GCVVLLMVPLNMYILPNYESDPGEH----SFWKLIALPKVGLIAFVINSLSSCFGFLDPTLSLFVLEkfnLPAGYVGLVF 277
Cdd:cd17489 157 AVLALLALLLVFLVKDPPPVAAEEAeagtRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAE---RGISNAGLFF 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 278 LGMALSYAISSPLFGLLSDKRPPlrKWLLVFGNLITAGCYMLLGPVPilhiksqlWLLVLILVVSGLSAGMSIIptFPEI 357
Cdd:cd17489 234 TVYAIALLLSRPFSGKLSDRKGP--KTVIIPGLLLLALGLLLLSFAG--------SPWMLLLAAVLYGLGFGLL--FPAL 301
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 358 LSCAHENGFEEGlstLGLVSGLFSAMWSIGAFMGPTLGGFLYEKIGFEWAAAIQGLWALIsGLAMGLFYL 427
Cdd:cd17489 302 QALAVDLVPPHR---RGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLL-ALVLYIFLL 367
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
47-418 |
1.08e-16 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 81.09 E-value: 1.08e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 47 SMMCYSILGPFFP---KEAEKKGASNTIIGMIFGCFALFELLASLVFGNYLVHIGAKFMFVAGMFVSGGVTILFGVLdrv 123
Cdd:cd17330 8 DALGFGIVFPVLPfyvREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLS--- 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 124 pdgpVFIAMCFLVRVMDAVSFAAAMTASSSILAKAFPNNVATVLGSLETFSGLGLILGPPVGGFLYQSFGYEVPFIVlGC 203
Cdd:cd17330 85 ----RNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLV-AA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 204 VVLLMVPLNMYILpnyesdpgehsfwkliaLPKVGLIAFVINSLSSCFGFLDPTLSLFVLEKFNLPAGYVGLVFLGMALS 283
Cdd:cd17330 160 ALALLNLVLVLFF-----------------LPPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIA 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 284 YAISSPLFGLLSDKRPPLRKwLLVFGNLITAGCYMLLGPVPILHIksqlwllvLILVVSGLSAGMSIipTFPEILSCAHE 363
Cdd:cd17330 223 GILAQLLLIPRLAKRLGERK-LLRLGLLLAIIGLLLLPFASSVPL--------LVLAAAILAFGTGI--VFPALSALLSK 291
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 16445357 364 NGfeeGLSTLGLVSGLFSAMWSIGAFMGPTLGGFLYEKIGFEWAAAIQGLWALIS 418
Cdd:cd17330 292 SV---PSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIA 343
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
51-425 |
1.54e-16 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 80.68 E-value: 1.54e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 51 YSILGPFFPKEAEKKGASNTIIGMIFGCFALFELLASLVFGNYLVHIGAKFMFVAGMFVSGGVTILFGVLDRVpdgPVFI 130
Cdd:cd17477 12 SGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSP---WVWF 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 131 AMCFLVRVMDAVSFaaaMTASSSILAKAFPNNVATVLGSLETFSGLGLILGPPVGGFLYQSfGYEVPFIVLGCVVLLMVP 210
Cdd:cd17477 89 LLRFVMGIGLAGLF---VVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTA-GALPFLIAAVLLLLALVP 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 211 LNMYILPNYESDPGEH-SFWKLIALPKVGLIAFVINSL--SSCFGFldptLSLFVLEKfNLPAGYVGLVFLGMALSYAIS 287
Cdd:cd17477 165 LLLTRRAAPEIEEAESiSLRRLLRIAPLALLGAFVAGFleGAFYSL----LPLYGLRL-GLSVAQAALLLAAFVLGGLLL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 288 SPLFGLLSDKRPplRKWLLVFGNLITAGCYMLLGPVPilhiksqlwLLVLILVVSGLSAGMSIIPTFPeiLSCAHENGFE 367
Cdd:cd17477 240 QWPLGWLADRFD--RRRVLLGCALLGALAALLLPLVP---------GLPLALLVLLFLWGGAAGPLYT--LALALAGDRL 306
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 16445357 368 EGlSTLGLVSGLFSAMWSIGAFMGPTLGGFLYEKIGfewaaaIQGLWALISGLAMGLF 425
Cdd:cd17477 307 PG-DELVAANAALLLLYGLGSVIGPLLAGALMDAFG------PHGLFLFLAAVALLFL 357
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
37-420 |
3.93e-15 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 76.46 E-value: 3.93e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 37 LISAASVNLGSMMCYSILGPFFPKEAEKKGASNTIIGMIFGCFALFELLASLVFGNYLVHIGAKFMFVAGMFVSGGVTIL 116
Cdd:cd17474 1 LYAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 117 FGVLDRvpdgpvfIAMCFLVRVMDAVSFAAAMTASSSILAKAFP-NNVATVLGSLETFSGLGLILGPPVGGFLyQSFGYE 195
Cdd:cd17474 81 CGLSDS-------FALLLAGRALQGIGAAGLGPLALTLIGDLFEgGERAKAMGLYEAALGLGIAVGPLLGGLL-AAISWR 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 196 VPFIVLGCVVLLMVPLNMYILPNyESDPGEHSFWKLIALPKV-----GLIAFVINSLSSCFGF--LDPTLSLFVLEKFNL 268
Cdd:cd17474 153 YPFFLLAALIPVAFLAILFLLPE-PKEKAKSSSATKLRDLKKalrgrGLLTFLVSAFLYFFLYfaFLTYLPFLLELLYGI 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 269 PAGYVGLVFLGMALSYAISSPLFGLLSDKRPpLRKWLLVFGNLITAGCYMLLGPVPILhiksqlwlLVLILVVSGLSAGM 348
Cdd:cd17474 232 SPIIIGLLFAGWSVLLALGSLFVGRLLKKRF-GARRILVIGLLLYALSLLLLGFVPSL--------ALLLIAIVLFGLGL 302
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 16445357 349 SIIPTfpeILSCAHENGFEEGLstLGLVSGLFSAMWSIGAFMGPTLGGFLYEKIGFEWAAAIQGLWALISGL 420
Cdd:cd17474 303 GLNLP---LLTTLVTELAPEEE--RGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAV 369
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
30-437 |
1.25e-12 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 69.11 E-value: 1.25e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 30 SREQVFVLISAASVNLGSMMCYSILGPFFPKEAEKKGASNTIIGMIFGCFALFELLASLVFGNYLVHIGAKFMFVAGMFV 109
Cdd:COG0738 3 KKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 110 SGGVTILFGVldrVPDGPVFIAMCFLVrvmdAVSFAAAMTASSSILAKAFPNNVATVLGSLETFSGLGLILGPPVGGFLY 189
Cdd:COG0738 83 MALGLLLFAL---APSYPLLLLALFLL----GLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 190 Q---SFGYEVPFIVLGCVVLLM------VPLNMYILPNYESDPGEHSFWKLIALPKVGLIAFVINSLSSCFGFLDPTLSL 260
Cdd:COG0738 156 LlglSLSWHLPYLILAVLLLLLallflrSKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 261 FVLEKFNLPAGYVGLVFLGMALSYAISSPLFGLLSDKRPPlRKWLLVFGNLITAGCY-MLLGPVPILhiksqlwllvLIL 339
Cdd:COG0738 236 YLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGP-VRLLRLSALLAAVGLLlALLAPGPWL----------ALI 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 340 VVSGLSAGMSIIptFPEILSCAHENGFEEGLSTLGLVsglfSAMWSIGAFMGPTLGGFLYEKIGFEWAaaiqgLWALISG 419
Cdd:COG0738 305 GLALVGLGLSLM--FPTIFSLALDGLGKRTAAAVSAV----LIMGIVGGAIGPPLIGFLADAFGLRAA-----FLVPLVC 373
|
410
....*....|....*...
gi 16445357 420 LAMGLFYLLEYSRRKRSK 437
Cdd:COG0738 374 YLLILLLALALKRKRRKK 391
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
66-418 |
2.78e-12 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 67.96 E-value: 2.78e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 66 GASNTIIGMIFGCFALFELLASLVFGNYLVHIGAKFMFVAGMFVSGGVTILFGVLdrvpdgPVFIAMcFLVRVMDAVSFA 145
Cdd:cd17324 30 GVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALA------PSFALL-LLARALAGLAHG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 146 AAMTASSSILAKAFP-NNVATVLGSLETFSGLGLILGPPVGGFLYQSFGYEVPFIVLGCVVLLMVPLNMYILPNYESDPG 224
Cdd:cd17324 103 GFWAIAAAYAADLVPpEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKP 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 225 EH-----SFWKLIALPKVGLIAFVINSLSSCFGFLDPTLSLFVLEKFNLPAGYVGLVFLGMALSYAISSPLFGLLSDKRP 299
Cdd:cd17324 183 GSlgllsSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGG 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 300 PLRkwlLVFGNLITAGCYMLLGPVPILHIksqLWLLVLILVVSGLSAGMSIIPTFpeILSCAHENgfeeglstLGLVSGL 379
Cdd:cd17324 263 RRA---LLIALLLLAAALLLLTLLGPSPL---LLLVGLVLWGLGFFAAHSALQTR--VLRLAPEA--------RGLASSL 326
|
330 340 350
....*....|....*....|....*....|....*....
gi 16445357 380 FSAMWSIGAFMGPTLGGFLYEKIGFEWAAAIQGLWALIS 418
Cdd:cd17324 327 YLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLA 365
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
40-421 |
2.84e-12 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 67.84 E-value: 2.84e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 40 AASVNLGSMMCYSILGPFFPKEAEKKGASNTIIGMIFGCFALFELLASLVFGNYLVHIGAKFMFVAGMFVSGGVTILFGV 119
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 120 ldrvpdgPVFIAMCFLVRVMDAVSFAAAMTASSSILAKAFP-NNVATVLGSLETFSGLGLILGPPVGGFLYQ--SFGYEV 196
Cdd:cd06174 81 -------APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPeRERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRA 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 197 PFIVLGCVVLLMVPLNMYILPNYESDPGE-----------HSFWKLIALPKVGLIAFVINSLSSCFGFLDPTLSLFVLEK 265
Cdd:cd06174 154 VFLIAAALALLAAILLLLVVPDPPESARAkneeassksvlKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 266 FNLPAGYVGLVFLGMALSYAISSPLFGLLSDKRPPLRKWLLVFGNLITAGC-YMLLGPVPILHIKSQLWLLVLILVVSGL 344
Cdd:cd06174 234 GGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLaLLLLAPSLLLLLLLLLLLGFGLGGLLPL 313
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 16445357 345 SAGMSIIPTFPEIlscahengfeeglstLGLVSGLFSAMWSIGAFMGPTLGGFLY-EKIGFEWAAAIQGLWALISGLA 421
Cdd:cd06174 314 SFALIAELFPPEI---------------RGTAFGLLNTFGFLGGAIGPLLAGFLLaATFGLTGAFLVLAVLLLLAAIL 376
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
37-425 |
4.75e-11 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 64.54 E-value: 4.75e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 37 LISAASVNLGSMMCYSILGPFFPK-EAEKKGASNTIIGMIFGCFALFELLASLVFGNYLVHIGAKF-----MFVAGMFVS 110
Cdd:COG2211 12 KLAYGLGDLGLNLAFGLLSAYLLYfYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWgrrrpWILIGAIPL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 111 GGVTILFGVLDRVPDGPVFIaMCFLVRVMDAVSFAAAMTASSSILAKAFPNNV--ATVLGSLETFSGLGLILGPPVGGFL 188
Cdd:COG2211 92 ALSFVLLFTAPDLSPTGKLI-YALVTYLLLGLAYTLVNIPYSALGAELTPDYEerTRLSSWRFAFAGLGGLLASVLPPPL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 189 YQSF------GYEVPFIVLGCVVLLMVPLNMYILPNYESDPGEHS----FWKLIALPKVGLIAFVINSLSSCFGFLDPTL 258
Cdd:COG2211 171 VAAFggdaalGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVslkeSLKALLKNRPFLLLLLAYLLFFLALALVAAL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 259 SLFVLEK-FNLPAGYVGLVFLGMALSYAISSPLFGLLSDKRPplRKWLLVFGNLITAGCYMLLgpvPILHIKSQLWLLVL 337
Cdd:COG2211 251 LLYYFKYvLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFG--KKKAFIIGLLLAALGLLLL---FFLGPGNLWLLLVL 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 338 ILVVSGLSAGMSIIPtFPEILSCAHENGFEEGLSTLGLVSGLFSAMWSIGAFMGPTLGGFLYEKIGFEWAA-----AIQG 412
Cdd:COG2211 326 AALAGIGLGAILVLP-WAMLADVVDYDEWKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGYVAGAaqspsALTG 404
|
410
....*....|...
gi 16445357 413 LWALISGLAMGLF 425
Cdd:COG2211 405 IRLLFFLLPAVLL 417
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
49-428 |
4.87e-11 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 64.16 E-value: 4.87e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 49 MCYSILGPFFPKEAEKKGASNTIIGMIFGCFALFELLASLVFGNYLVHIGAKFMFVAGMFVSGGVTILFGVLDRVPdgpv 128
Cdd:cd17331 14 TCYWLQQPVLPYLTKKLGVDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVP---- 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 129 fiaMCFLVRVmdAVSFAAAMTASSSILAK-AFPNNVATVLGSLETFSGLGLILGPPVGGFLYQSFGYEVPFIVLGCVVLL 207
Cdd:cd17331 90 ---MLFLSRL--PSVFMHAMQAAQMVVTDlTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 208 MVPLNMYILPNYE------------SDPGEHSFWKLIAL---PKVGLIAFVINSLSSCFGFLDPTLSLFVLEKFNLPAGY 272
Cdd:cd17331 165 SIVLVILLIPSNTkskrekeakesaSPPSVFNLKEILRLlrlPGVAFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEE 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 273 VGLVFLGMALSYAIS-----SPLFGLLSDKRpplrkwLLVFGNLITAGCYMLLGPVPilhiksqlWLLVLILVVSGLSAG 347
Cdd:cd17331 245 NGYLMSYAGVLGMVVqgllvGPLTKRFGERS------LLKLSVALLAIGYLLLAFVT--------TVWQLLVLLLPLVIG 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 348 MSIIPTfpeILSCAHENGFEEglSTLGLVSGLFSAMWSIGAFMGPTLGGFLYEKIGFewaAAIQGLWALISGLAmgLFYL 427
Cdd:cd17331 311 GSVLYT---VITSLLTKAVPP--EDTGTALGLSHALFSLVRTVSPTIGGALLQAYGF---PSFGLLGAAINGLL--TVYL 380
|
.
gi 16445357 428 L 428
Cdd:cd17331 381 L 381
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
45-422 |
1.91e-10 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 62.18 E-value: 1.91e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 45 LGSMMCYSILGPFFpkeaEKKGASNTIIGMIFGcfaLFELLASL--VFGNYLVHI--GAKFMFVAGMFVSGGVTILFGVL 120
Cdd:cd17370 13 ISYEMARSILPLFL----VVLGASAAAVGLIEG---LAEALGSLlrLFSGYLSDRtgKRKPLVILGYGLSALAKPLLALA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 121 DRVPDgpVFIAMcFLVRVMDAVSFAA--AMTASSSI---LAKAFpnnvatvlGSLETFSGLGLILGPPVGGFL--YQSFG 193
Cdd:cd17370 86 GSWQL--VLLLR-ILERLGKGIRTPPrdALLADATPpsgRGKAF--------GLHRALDTLGAVLGPLLAALLlyLLGGN 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 194 YEVPFIVLGCVVLLMVPLNMYILPNYE--SDPGEHSFW-KLIALPKVGLIAFVINSLSScFGFLDPTLSLFVLEKFNLPA 270
Cdd:cd17370 155 YRTIFLLAAIPALLALLILLFVVKEYPrpPKLRKKSKKtSLKKLPKAFWLYLLAVALFA-LGNFSFAFLILRAQELGLSA 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 271 GYVGLVFLGMALSYAISSPLFGLLSDKRPplRKWLLVFGNLITAGCYMLLGPVPILHiksqLWLLVLILVVSGLSAGMSI 350
Cdd:cd17370 234 ALIPLLYALFNLVYALAAYPAGRLSDRIG--RKKLLILGYLSLALAYLGFALGSSLW----LLLLGFILWGLYMGAQESI 307
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 16445357 351 IPTFPEILSCAHENGFeeglstlglVSGLFSAMWSIGAFMGPTLGGFLYEKIGFEWAAAIQGLWALISGLAM 422
Cdd:cd17370 308 ERAAVADLVPAELRGT---------AYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLL 370
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
52-421 |
4.77e-10 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 61.05 E-value: 4.77e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 52 SILGPFFPKEAekkGASNTIIGMIFGCFALFELLASLVFGNYLVHIGAKFMFVAGMFVSGGVTILFGVLDRVpdgpvfiA 131
Cdd:cd17319 23 SVAAPTIMKDL---GLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSL-------T 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 132 MCFLVRVMDAVSFAAAMTASSSILAKAFPNNV-ATVLGSLETFSGLGLILGPPVGGFLYQSFGYEVPFIVLGCVVLLMVP 210
Cdd:cd17319 93 SLYVLRFLLGVAEAGFFPGAIKALAEWFPARErGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAV 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 211 LnmyilpnyesdpgehsfWkLIALPKVGLIAFVINSLSSCFGFLDPTLSLFVLEKFNLPAGYVGLVFLGMALSYAISSPL 290
Cdd:cd17319 173 L-----------------W-WFYLRQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMIL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 291 FGLLSDKRPPL-RKWLLVFGNLITAGCYMLLGPVPILHIKSQLWLLVLILVVSGLSAGMSIIPTFPeilscahengfeeG 369
Cdd:cd17319 235 GGRLSDRLLRGaRRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLL-------------P 301
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 16445357 370 LSTLGLVSGLFSAMWSIGAFMGPTLGGFLYEKIG-FEWAAAIQGLWALISGLA 421
Cdd:cd17319 302 GEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGsYTAAFLFLAAVALLAALL 354
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
97-320 |
1.06e-09 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 59.88 E-value: 1.06e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 97 IGAKFMFVAGMFVSGGVTILFGVldrVPDGPVFIAMcflvRVMDAVSFAAAMTASSSILAKAFP-NNVATVLGSLETFSG 175
Cdd:cd17321 58 FGRKRVFLIGLALFGLASLLCAL---APSLAFLIAA----RALQGIGAAAIMPASLALIAATFPgERRGRALGLWGAVVG 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 176 LGLILGPPVGGFLYQSFGYEVPFIV---LGCVVLLMVPlnMYILPNyesdpgehsfwklialpkvgLIAFVINSLSSCFG 252
Cdd:cd17321 131 IGAALGPLLGGLLLELFGWRWIFLInvpIGLVALLLAR--TFSGAV--------------------LAAFLLGAALGGLL 188
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 16445357 253 FLdptLSLFVLEKFNLPAGYVGLVFLGMALSYAISSPLFGLLSDKRPPlrKWLLVFGNLITA-GCYMLL 320
Cdd:cd17321 189 FL---LPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGP--RLVLVAGLLLTAvGLLLLA 252
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
30-321 |
1.41e-09 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 59.05 E-value: 1.41e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 30 SREQVFVLISAASVNLGSMMCYSILGPFFPKEAEKKGASNTIIGMIFGCFALFELLASLVFGNYLVHIGAKFMFVAGMFV 109
Cdd:COG0477 9 TRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 110 SGGVTILFGVLdrvPDGPVFIAMcflvRVMDAVSFAAAMTASSSILAKAFPNNV-ATVLGSLETFSGLGLILGPPVGGFL 188
Cdd:COG0477 89 FGLASLLCGLA---PSPELLIAA----RALQGIGAGGLMPGALALIAELFPARErGRALGLWGAAIGLGLALGPLLGGLL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 189 YQSFGYEVPFIVLGCVVLLMVPLNMYILPNYESDPGEHSFWKLIALPKVGLIAFVINSLSSCFGFLDPTLSLFVLEKFNL 268
Cdd:COG0477 162 VAALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLL 241
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 16445357 269 PAGYVGLVFLGMALSYAISSPLFGLLSDKRPPLRKWLLVFGNLITAGCYMLLG 321
Cdd:COG0477 242 LLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALL 294
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
35-426 |
1.67e-09 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 59.16 E-value: 1.67e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 35 FVLISAASVNLGSMMCYSILGPFFpkeAEKKGASNTIIGMIFGCFALFELLASLVFGNYLVHIGAKFMFVAGMFVSGGVT 114
Cdd:cd17329 3 VLLIGSFLNRLGFFMVWPFMAIYL---HQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 115 ILFGVLDRVPdgpVFIAMCFLVRVMDAVSFaaamTASSSILAKAFPN-NVATVLGSLETFSGLGLILGPPVGGFLYQsFG 193
Cdd:cd17329 80 ALLGFAHSPW---LFAIALVLTGFGGGLFE----PASEAMIADVTTPeNRTRAFSLLYWAINLGVAIGPLLGGLLLL-YS 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 194 YEVPFIVLGCVVLLMVPLNMYILPNYESDPGEHSF------WKLIALPKVGLIAFVINSL-SSCFGFLDPTLSLFVLEKF 266
Cdd:cd17329 152 FRLLFLAAAVLFLLAALVLLFLLPETRPKRRAAEKteilrgYKIVLRDRAFLLFLLASFLiSLIYFQLESTLPVYVVEIL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 267 NLPAGYVGLVF-LGMALSYAISSPLFGLLSDKRPplRKWLLVFGNLITAGCYMLLGPVPILHIksqlwllvlilvvsgls 345
Cdd:cd17329 232 GLGESLLGLLLaLNALLIVLLQFPVARLVERFRL--RKILMIGILLFAIGFAVLAFANTLAVL----------------- 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 346 AGMSIIPTFPEILSCAHENGFEEGLS---TLGLVSGLFSAMWSIGAFMGPTLGGFLYEKIGFEWAAAIQGLWALISGLAM 422
Cdd:cd17329 293 ILAMIVLTLGEMLVFPAVQTLVAALAppdKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALL 372
|
....
gi 16445357 423 GLFY 426
Cdd:cd17329 373 LGLQ 376
|
|
| MFS_SLC18A3_VAChT |
cd17383 |
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator ... |
49-278 |
2.31e-09 |
|
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator Superfamily; Vesicular acetylcholine transporter (VAChT) is also called solute carrier family 18 member 3 (SLC18A3) in vertebrates and uncoordinated protein 17 (unc-17) in Caenorhabditis elegans. It is a glycoprotein involved in acetylcholine transport into synaptic vesicles and is responsible for the accumulation of acetylcholine into pre-synaptic vesicules of cholinergic neurons. Variants in SLC18A3 are associated with congenital myasthenic syndrome in humans. VAChT belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340941 [Multi-domain] Cd Length: 378 Bit Score: 58.86 E-value: 2.31e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 49 MCYSILGPFFPKEAEkkgaSNTIIGMIFGCFALFELLASLVFGNYLVHIGAKFMFVAG---MFVSGGVTIL---FGVLdr 122
Cdd:cd17383 13 MLYMVIVPIIPDYLN----EDIAIGVLFASKAIVQLLVNPFSGTLIDRVGYDIPMMIGltvMFLSTAVFAFgesYAVL-- 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 123 vpdgpvfiamcFLVRVMDAVSFAAAMTASSSILAKAFP--NNVATVLGSLETFSGLGLILGPPVGGFLYQSFGYEVPFIV 200
Cdd:cd17383 87 -----------FFARSLQGVGSAFADTAGLAMIADRFTeeAERSKALGIALAFISFGCLVAPPFGGILYEFAGKEVPFLI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 201 LGCVVLLMVPLNMYILPNYESDPGEHS-------FWKLIALPkvgLIAFVINSLSSC---FGFLDPTLSLFVLEKFNLPA 270
Cdd:cd17383 156 LAFVCLLDGLLLLLVMKPVRRETRANMpepvgtpIHRLLMDP---YIAVCAGALTMAnvsLAFLEPTIANWMKDTMNASE 232
|
....*...
gi 16445357 271 GYVGLVFL 278
Cdd:cd17383 233 WQMGLVWL 240
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
56-426 |
8.44e-09 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 57.23 E-value: 8.44e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 56 PFFPKEAEKKGASNTIIGMIFGCFALFELLASLVFGNYLVHIGAKFMFV-AGMFVSGGVTILFGVldrVPDGpvfiAMCF 134
Cdd:cd17490 17 PFLSPYAESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLFIiIGLLFTVLASLIMIL---FPSP----WGLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 135 LVRVMDAVsfAAAMTASSSILAKAF--PNNVATVLGSLETFSGLGLILGPPVGGFLYQSFGYEVPFIVLGCVVLLMVPLN 212
Cdd:cd17490 90 IARFLSGI--AAATWVSFTVLYASYfpPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILS 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 213 MYI----LPNYESDPGEHSFWKLIALPKV------GLIAFVINsLSSCFGFLDPTLSLFVLEKFNLpagyvGLVFLGMAL 282
Cdd:cd17490 168 LFIkeerREKKPVLTELKELLSVLKDKKLlffsllAILQQMIT-FSTTFGFTPLIAKQLGASSFQL-----GLLSIIYLL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 283 SYAISSPLFGLLSDKRPPLRKWLLvFGNLITAGCYMLLGPVPILHIksqlwllvLILVVSGLSAGMSIIptFPEILSCAH 362
Cdd:cd17490 242 PNALASLLSGTLFYKKLGERNTII-IGFLLLGAYCFLIPFAPNLTL--------LYLLQALNGFGTGIL--FPLLMSLSI 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 16445357 363 ENGFEEGLSTlglVSGLFSAMWSIGAFMGPTLGGFLYEKIGFEWAAAIQGLWALISGLAMGLFY 426
Cdd:cd17490 311 EGVPAEQRST---AMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAILSLAYY 371
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
18-214 |
8.76e-09 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 57.22 E-value: 8.76e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 18 PAGSAGETPGWLSREQVFVLISAASVNLGSMmCYSILGPFFPKEAEKKGASNtiIGMIFGCFALFELLASLVFGNYLVHI 97
Cdd:cd17489 178 AEEAEAGTRAFRRLVEKKVLPPALILFLASI-AYGAISTFLPLYAAERGISN--AGLFFTVYAIALLLSRPFSGKLSDRK 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 98 GAKFMFVAGMFVSGGVTILFGVLDrvpdgpvFIAMCFLVRVMDAVSFAAAMTAS-SSILAKAFPNNVATVLGSLETFSGL 176
Cdd:cd17489 255 GPKTVIIPGLLLLALGLLLLSFAG-------SPWMLLLAAVLYGLGFGLLFPALqALAVDLVPPHRRGAANGTFFIFFDL 327
|
170 180 190
....*....|....*....|....*....|....*...
gi 16445357 177 GLILGPPVGGFLYQSFGYEVPFIVLGCVVLLMVPLNMY 214
Cdd:cd17489 328 GIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIF 365
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
52-276 |
1.23e-07 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 53.38 E-value: 1.23e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 52 SILGPFFPKEAEKKGASNTIIGMIFGCFALFELLASLVFGNYLVHIGAKFMFVAGMFVSGGVTILFGVldrvpdgPVFIA 131
Cdd:cd17390 13 SMILPLLSTHIRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGF-------STSLA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 132 MCFLVRVMDAVsFAAAMTASSSILAKAFPNN-VATVLGSLETFSGLGLILGPPVGGFLYQ-SFGYEVPFIVLGCVVLLMV 209
Cdd:cd17390 86 LLFLSRIPLGI-FKHTQSLCKAYLSDLVSEQeRSRVLGRFNAASSLGFILGPVVGGHLAEtDGGFYYVALLCSAIFILNA 164
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 16445357 210 PLNMYILPNYesdpgehsfWKLIALPKvgLIAFVINSLSSCFgfldptlSLFVLEKFNLPAGYVGLV 276
Cdd:cd17390 165 GLVWFLLSKL---------WDLLLVRF--LMGFSVLLFRSNF-------SLYLEERFDLSPKTIGYL 213
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
34-428 |
2.16e-07 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 52.95 E-value: 2.16e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 34 VFVLISAASVNLGSMMcySILGPFFPKEAEKKGASNTIIGMIFG----CFALFELLASLVfgnyLVHIGAKFMFVAGMFV 109
Cdd:COG2807 19 LLLAIVLVALNLRPAI--TSVGPLLPEIRADLGLSATQAGLLTTlpllAFGLFAPLAPRL----ARRFGLERTLLLALLL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 110 SGGVTILFGVldrVPDGPVFIAMCFLVrvmdAVSFAAAMTASSSILAKAFPNNVATVLGSLETFSGLGLILGPPVGGFLY 189
Cdd:COG2807 93 LAAGLLLRSL---APSVALLLAGTALI----GAGIAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 190 QSFGYEVPFIVLGCVVLLMVPLNMYILPNYESDPGE-------HSFWKLIALPKVGLIAFVINSLSSC-FGFLDPtlslf 261
Cdd:COG2807 166 AALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAapaaaslRSLWRSPLAWLLTLFFGLQSLLYYAvVAWLPP----- 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 262 VLEKFNLPAGYVGLVFLGMALSYAISSPLFGLLSDKRPPLRKWLLVFGNLITAGCYMLLgpvpilhiksqlWLLVLILVV 341
Cdd:COG2807 241 ILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLL------------LAPGSLPWL 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 342 SGLSAGMSIIPTFPeiLSCAHENGFEEGLSTLGLVSGLFSAMWSIGAFMGPTLGGFLYEKIGfEWAAAIqgLWALISGLA 421
Cdd:COG2807 309 WAVLLGLGQGGLFP--LALTLIGLRARTPAEAAALSGMAQSVGYLLAALGPLLVGALHDATG-SWTAAL--LLLAALAVL 383
|
....*..
gi 16445357 422 MGLFYLL 428
Cdd:COG2807 384 MLVAGLL 390
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
42-320 |
5.19e-07 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 51.39 E-value: 5.19e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 42 SVNLGSMMCYSILGPFFPK-EAEKKGASNTIIGMIFGCFALFELLASLVFGNYL-VHIGAKFMFVAGMFVSGGVTILFGV 119
Cdd:cd17471 3 LATLLTGLAGAFVLPYLSLfLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSdRGGDRKPLILLALLAGALGYLLFAF 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 120 LDrvpDGPVFIAMCFLVRVMDAVSFAAAMTASSSILAKAFPNNVATVLGSLETFSGLGLILGPPVGGFLYQSFGYEVPFI 199
Cdd:cd17471 83 LR---NYWVLLLVGVVLLSLGAAAFPQLFALAREYADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 200 VLGCVVLLMVPLNMYILPNYESDPGE----HSFWKLIALPKVGLIAFVINSLSSCFGFLDPTLSLFVLEKFNLPAGYVGL 275
Cdd:cd17471 160 LAALLYLVVALLVLFLLPSVKPPAQKatpaSSLVKAPVNRRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGGSESWVGL 239
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 16445357 276 VflgMALSYAISSP---LFGLLSDKRPplRKWLLVFGNLITAGCYMLL 320
Cdd:cd17471 240 L---FGLAAALEIPimlLAGLLAKRFG--KRRLLLAGFLAGVLFYLGL 282
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
66-321 |
1.78e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 49.92 E-value: 1.78e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 66 GASNTIIGMIFGCFALFELLASLVFGNYLVHIGAKFMFVAGMFVSGGVTILFGVL---DRVPDGPVFIAMcFLVRVMDAV 142
Cdd:cd06173 30 TGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLallGSLSLWLLLVLA-FLLGIASAF 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 143 SFAAAMTASSSILAKafpNNVATVLGSLETFSGLGLILGPPVGGFLYQSFGYEVPFIVLGCVVLLMVPLNMYILPNYESD 222
Cdd:cd06173 109 FGPARQALLPELVPK---EQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRRPPPAA 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 223 PGEHSFWKLIAL---------PKVGLIAFVINSLSSCFGFLDPTLS-LFVLEKFNLPAGYVGLVFLGMALSYAISSPLFG 292
Cdd:cd06173 186 PGESSSLLLRDLreglrylrrSPLLRLLLLALALFALLGGALTVLLpLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLG 265
|
250 260
....*....|....*....|....*....
gi 16445357 293 LLSDKRPPLRkwLLVFGNLITAGCYMLLG 321
Cdd:cd06173 266 RLSKRRRRGR--LLLIGALLLGLALLVLG 292
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
240-439 |
4.31e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 48.57 E-value: 4.31e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 240 IAFVINSLSSCFGFLDPTLSLFVLEKFNLPAGYVGLVFLGMALSYAISSPLFGLLSDKRPplRKWLLVFGNLITAGCYML 319
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFG--RRRVLLIGLLLFALGLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 320 LGPVPilhiksqlWLLVLILVVSGLSAGMSIIPTFPEILSCAHENGFEeglstLGLVSGLFSAMWSIGAFMGPTLGGFLY 399
Cdd:pfam07690 79 LLFAS--------SLWLLLVLRVLQGLGAGALFPAALALIADWFPPEE-----RGRALGLVSAGFGLGAALGPLLGGLLA 145
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 16445357 400 EKIGFEWAAAIQGLWALISGLAmgLFYLLEYSRRKRSKSQ 439
Cdd:pfam07690 146 SLFGWRAAFLILAILSLLAAVL--LLLPRPPPESKRPKPA 183
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
251-443 |
4.53e-06 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 48.70 E-value: 4.53e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 251 FGFLDPTLSLFVLEKFNLPAGYVGLVFLGMALSYAISSPLFGLLSDKRPPlRKWLLVFGNLITAGCYMLLGpvpilHIKS 330
Cdd:cd17471 12 GAFVLPYLSLFLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRGGD-RKPLILLALLAGALGYLLFA-----FLRN 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 331 QLWLLVLILVVSGLSAgmsiiPTFPEILSCAHENGFEEGLSTLGLVSGLFSAMWSIGAFMGPTLGGFLYEKIGFEWAAAI 410
Cdd:cd17471 86 YWVLLLVGVVLLSLGA-----AAFPQLFALAREYADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLL 160
|
170 180 190
....*....|....*....|....*....|...
gi 16445357 411 QGLWALISGLAmgLFYLLEYSRRKRSKSQNILS 443
Cdd:cd17471 161 AALLYLVVALL--VLFLLPSVKPPAQKATPASS 191
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
62-217 |
4.55e-06 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 48.71 E-value: 4.55e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 62 AEKKGASNTIIGMIFGCFALFELLASLVFGNYLVHIGAKFMFVAgMFVSGGVTILFGVLDRVPDGPVFIAMCFLVrvmdA 141
Cdd:COG2271 208 VEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVL-AIGLLLAALALLLLALLPSPALAIALLFLA----G 282
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 16445357 142 VSFAAAMTASSSILAKAFP-NNVATVLGSLETFSGLGLILGPPVGGFLYQSFGYEVPFIVLGCVVLLMVPLNMYILP 217
Cdd:COG2271 283 FGLGGAFGLLWALAAELFPkKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLR 359
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
49-421 |
6.48e-06 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 47.94 E-value: 6.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 49 MCYSILGPFFPKEAEKKGASNTIIGMIFGCFALFELLASLVFGNYLVHIGAKFMFVAGMFVSGGVTILFGVldrVPDGPV 128
Cdd:cd17478 10 FYQGFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGF---APNYWL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 129 FIAMCFLVrvmdAVSFAAAMTASSSILAKAFPNNVATVLGSLETFSGLGLILGPPVGGFLYQSFGYE-------VPFIVL 201
Cdd:cd17478 87 LLLLVALA----GIGSAAFHPEGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLgllilliIPGLAV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 202 GCVVLLMVPLNMYILPNYESDPGEHSFWKLIALPkVGLIAFVINSLSSCFGFLDPTLSLFVLEKFNLPAGYVGLVFLgMA 281
Cdd:cd17478 163 ALLLLRLRPLKKPEAKKAAAKSSARSTLKGVWRA-LLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSL-FL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 282 LSYAISSPLFGLLSDKRPplRKWLLVFGNLITAGCYMLLGPVPilhiksqlwllVLILVVSGLSAGMSIIPTFPEILSCA 361
Cdd:cd17478 241 FAGAIGTLIGGPLSDRFG--RRRVIIASLLLAAPFLLLFLLTP-----------GIWSYILLVLAGFLLFASFPVTVVLA 307
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 16445357 362 HENGFEeglsTLGLVSGLFSA-MWSIGAFMGPTLgGFLYEKIGFEWAAAIQGLWALISGLA 421
Cdd:cd17478 308 QELLPG----NVGLASGLMMGlSFGLGGIGAPVL-GALADAFGLESVLLILALLPLLGALL 363
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
52-312 |
1.43e-05 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 46.87 E-value: 1.43e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 52 SILGPFFPKEAEKKGASNTII-----GMIFGCFALFELLASLVFGNYLVHIGAKFMFVAGMFvsgGVTILFGVLDRVPDG 126
Cdd:cd17391 13 SLIAPFLPLYIEQLGVTSGGLvelwsGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASL---GMAIVIGLMAFVTNV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 127 PVFIAMCFLVRVmdavsFAAAMTASSSILAKAFPNNVA-TVLGSLETFSGLGLILGPPVGGFLYQSFGYEVPFIVLGCVV 205
Cdd:cd17391 90 WQLLILRLLQGV-----FSGYVPNATALIASQTPKEKSgWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGLL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 206 LLMVPLNMYIL------PNYESDPGEHSFWKLIALPKVGLIAFVINSLS-SCFGFLDPTLSLFVlEKFNLPAGYV----G 274
Cdd:cd17391 165 FLAFLLTLFFVkedfkpVEKKKMVSTKEVWNSVPNPSLLISLFVTTFIIqLANQSIEPILTLYI-RQLMGDASNLafisG 243
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 16445357 275 LVFLGMALSYAISSPLFGLLSDKRPPLRKWL--LVFGNLI 312
Cdd:cd17391 244 LVFSATGVSSLLSAPRLGKLGDRIGHHRILLgaLLASALL 283
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
54-420 |
1.53e-05 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 46.88 E-value: 1.53e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 54 LGPFFPKEAEKKGASNTIIGMIFGCFALFELLASLVFGNYLVHIGAKFMFVAGMFVSGGVTILFGVldrVPDGPVFIAMC 133
Cdd:cd17355 22 FGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLAL---ATSLWQLYLLW 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 134 FLVRVMDAVSFAAAMTASssILAKAFPNNVATVLGSLETFSGLGLILGPPVGGFLYQSFGYEVPFIVLGCVVLLMVPLNM 213
Cdd:cd17355 99 GLLGGGGAGTLAAVAFAT--VAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 214 YILPNYESDPGEHSFW--KLIALPKVGLIAF--------VINSLSSCFGFLDPTLSLFV-LEKFNLPAGYVGLVFLGMAL 282
Cdd:cd17355 177 LLLRRRPADLALRAYDdaSPASPGSTLKEALrsasfwllALAFFLCGFAVVGLIVHLVPyLADRGISPAAAAVALALIGL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 283 SYAISSPLFGLLSDKRPPLRKWLLVFGNLITAGCYMLLGPVPILhiksqlwLLVLILVVSGLSAGMSIIPTfpeILSCAH 362
Cdd:cd17355 257 FNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPL-------ALLLFAALFGLGWGATVPLT---AALAAR 326
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 16445357 363 ENGFEEglstLGLVSGLFSAMWSIGAFMGPTLGGFLYEKIG-FEWAAAIQGLWALISGL 420
Cdd:cd17355 327 YFGARS----YGTLFGLVFAPHQLGSALGPWLGGLLYDRTGsYTAAWALAVALGLIAAL 381
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
226-452 |
1.88e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 46.51 E-value: 1.88e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 226 HSFWKLIALPKVGLIAFVInslSSCFGFLDPTLSLFVLEkFNLPAGYVGLVFLGMALSYAISSPLFGLLSDKRPplRKWL 305
Cdd:COG2814 4 TPRRRWLALLALALGAFLS---GLGIGIVLPALPLIAAD-LGASPAQAGLVVTAYLLGAALGAPLAGRLADRFG--RRRV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 306 LVFGNLITAGCYMLLGPVPILHIKSQLWLLVLILVVSGLSAGMSIIP-TFPEilscahengfeeglSTLGLVSGLFSAMW 384
Cdd:COG2814 78 LLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIAdLVPP--------------ERRGRALGLLGAGL 143
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 16445357 385 SIGAFMGPTLGGFLYEKIGFEWAAAIQGLWALISGLAMGLFYLLEYSRRKRSKSQNILSTEEERTTLL 452
Cdd:COG2814 144 GLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRELLRRPRLLL 211
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
54-209 |
2.35e-05 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 46.50 E-value: 2.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 54 LGPFFPKEAEKKGASNTIIGMIFGCFALFELLASLVFGNYLVHIGAKFMFVAGMFVSGGVTILFGVLDRVPDGPVFIAMC 133
Cdd:cd17312 22 FSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLN 101
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 16445357 134 FLVRVMDAVSFAAAMTASSSilakafPNNVATVLGSLETFSGLGLILGPPVGGFLYQSFGYEVPFIVLGCVVLLMV 209
Cdd:cd17312 102 GLFQSMGWPPCVKLLGNWFS------KKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVA 171
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
48-424 |
4.18e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 45.67 E-value: 4.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 48 MMCYSILGPFFpKEAEKKGASNTIIGMIFGCFALFELLASLVFGNYLVHIGAKFMFVAGMFVSGGVTILFGVLdrvpdgP 127
Cdd:cd17316 15 FFLIGFVAPVL-AAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLL------P 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 128 VFIAMcFLVRVMDAVSFAAAMTASSSILAKAFP-NNVATVLGSLETFSGLGLILGPPVGGFLYQSFGYE----VPFIVLG 202
Cdd:cd17316 88 TPILL-LVLRFLQGIGIGGEYPGASTYVAEFAPsKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDwgwrILFLIGA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 203 CVVLLMVPLNMYILpnyesdpgehsfwklialpKVGLIAFVINSLSSCFGFLDPTLSLFVLekfNLPAGYVGLVFLGMAL 282
Cdd:cd17316 167 LPALLALLLRRRTL-------------------LLILLWFFISFGYYGLTTFLPTYLQTVL---GLSPATSSLYLLLISL 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 283 SYAISSPLFGLLSDKRPplRKWLLVFGNLITAGCYMLLGPVPILHIKSQLWLLVLILVVSGLSAGMSIIpTFPEILScah 362
Cdd:cd17316 225 GALVGALIAGLLSDRIG--RKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYA-YLAELFP--- 298
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 16445357 363 engfeegLSTLGLVSGLFSAMWSIGAFMGPTLGGFLYEKIGFEWAAAIQGLWALISGLAMGL 424
Cdd:cd17316 299 -------TEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
257-452 |
7.44e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 44.91 E-value: 7.44e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 257 TLSLFVLEKFNLPAgYVGLVFLGMALSYAISSPLFGLLSDKRPplRKWLLVFGNLITAGCYMLLgpvPILHIKSQLWLLV 336
Cdd:cd06173 21 ALPWLVLQLTGSAL-LVGLVLAAFFLPFLLFSPFAGVLADRFD--RRRLLILADLLRALLAAVL---ALLALLGSLSLWL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 337 LILVVSGLSAGMSI-IPT----FPEILScahengfEEGLSTLglvSGLFSAMWSIGAFMGPTLGGFLYEKIGFEWAAAIQ 411
Cdd:cd06173 95 LLVLAFLLGIASAFfGPArqalLPELVP-------KEQLVRA---NALNSLATQLARIIGPALGGLLVALLGPGGAFAIN 164
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 16445357 412 GLWALISGLAMGLFYLLEYSRRKRSKSQNILSTEEERTTLL 452
Cdd:cd06173 165 ALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREGLRYLR 205
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
34-194 |
8.28e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 44.89 E-value: 8.28e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 34 VFVLISAASVNLGSMMCYSILGPFFpkeAEKKGASNTIIGMIFGCFALFELLASLVFGNYLVHIGAKFMFVAGMFVSGGV 113
Cdd:COG2211 231 LLLLLAYLLFFLALALVAALLLYYF---KYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALG 307
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 114 TILFGVLDRVPDGPVFIAMCFLvrvmdAVSFAAAMTASSSILAKAFP--------NNVATVLGSLETFSGLGLILGPPVG 185
Cdd:COG2211 308 LLLLFFLGPGNLWLLLVLAALA-----GIGLGAILVLPWAMLADVVDydewktgrRREGLYFGIFTFAIKLGQALAGALA 382
|
....*....
gi 16445357 186 GFLYQSFGY 194
Cdd:COG2211 383 GLLLALFGY 391
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
97-224 |
1.51e-04 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 43.86 E-value: 1.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 97 IGAKFMFVAGMFVSGGVTILFGVLDRVPdgpVFIAMCFLvrvmDAVSFAAAMTASSSILAKAF-PNNVATVLGSLETFSG 175
Cdd:cd17343 65 ISARWLFSSGLVLSGLTTVAFSGSSSVW---VFSILWFL----NGLAQGLGWPPCAKILRKWFsPSQFGTWWSVLSTSMN 137
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 16445357 176 LGLILGPPVGGFLYQSFGYEVPFIVLGCVVLLMVPLNMYILPNYESDPG 224
Cdd:cd17343 138 LAGSLGPILATLLALSYGWRSTLSISGTVAVVMSVVCLLFIKNEPSDVG 186
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
236-443 |
1.64e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 43.76 E-value: 1.64e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 236 KVGLIAFVINSLSscFGFLDPTLSLFVLEKFNLPAGYVGLVFLGMALSYAISSPLFGLLSDKRPplRKWLLVFGNLITAG 315
Cdd:cd17329 2 WVLLIGSFLNRLG--FFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFG--RKPVMLAGLLLRAL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 316 CYMLLGpvpilhIKSQLWLLVLILVVSGLSAGMSIIPTFPEILSCAHENGFEEGLStlglvsgLFSAMWSIGAFMGPTLG 395
Cdd:cd17329 78 GFALLG------FAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFS-------LLYWAINLGVAIGPLLG 144
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 16445357 396 GFLYEkIGFEWAAAIQGLWALISGLAMGLFYLLEYSRRKRSKSQNILS 443
Cdd:cd17329 145 GLLLL-YSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAAEKTEILR 191
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
47-427 |
2.50e-04 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 42.95 E-value: 2.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 47 SMMCYSILGPFFPKEAEKKGASNTIIGMIFGCFALFELLASLVFGNYLVHIGAKFMFVAGMFVSGGVTILFGVldrVPDg 126
Cdd:cd17323 11 VTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCAL---APN- 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 127 pvfIAMCFLVRVMDAVSFAAAMTASSSILAKAF-PNNVATVLGSLETFSGLGLILGPPVGGFLYQSFGYEVPFIVL---- 201
Cdd:cd17323 87 ---IAMLIILRFLQGFFGSSPLAIGAGTIADLFtPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLaiis 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 202 GCVVLLMVPLnmyilpnyesdpgehsfwkliaLPKVGLIAFVINSLSSCFGFLDPTLSLFVLEKFNLPAGYVGLVFLGMA 281
Cdd:cd17323 164 GFCLILIFLF----------------------LPIVLLLGLYVGLVYAILYLFLTAFPYVFGEVYGFSPGEVGLMYLPIG 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 282 LSYAISSPLFGLLSDK-------------RPPLRKWLLVFGNLITAGCYMLLG---------PVPILhiksqlwllvlIL 339
Cdd:cd17323 222 IGALIGSIIGGRLSDYyyrrlkkknggkpEPEARLPPAFIGAFLFPIGLFIFGwtiyphihwIVPII-----------GS 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 340 VVSGLSAGMSIIPTFPEILSCAHENGfeeglstlGLVSGLFSAMWSIGAFMGPTLGGFLYEKIGFEWAAAIQGLWALISG 419
Cdd:cd17323 291 AFFGFGLMLIFQSSLTYLVDSYPKYA--------ASALAANTLVRSIFAAIFPLFAQPMFNNLGVGWAFTLLAFISLAMI 362
|
....*...
gi 16445357 420 LAMGLFYL 427
Cdd:cd17323 363 PIPFIFYK 370
|
|
| PRK03545 |
PRK03545 |
putative arabinose transporter; Provisional |
167-323 |
3.22e-04 |
|
putative arabinose transporter; Provisional
Pssm-ID: 179591 [Multi-domain] Cd Length: 390 Bit Score: 42.96 E-value: 3.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 167 LGSLETFSGLGLILGPPVGGFLYQSFGYEVPFIVLGCVVLLMVPLNMYILPNYESdpgEH--SFWKLIALPK-------V 237
Cdd:PRK03545 135 LSLLATGTALAMVLGLPLGRVIGQYLGWRTTFLAIGGGALITLLLLIKLLPLLPS---EHsgSLKSLPLLFRrpalvslY 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 238 GLIAFVINSLSSCFGFLDPtlslFVLEKFNLPAGYVGLVFLGMALSYAISSPLFGLLSDKRPplrKWLLVFGNLITAGCY 317
Cdd:PRK03545 212 LLTVVVVTAHFTAYSYIEP----FVQQVAGLSENFATLLLLLFGGAGIIGSVLFSRLGNRHP---SGFLLIAIALLLVCL 284
|
....*.
gi 16445357 318 MLLGPV 323
Cdd:PRK03545 285 LLLLPA 290
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
130-323 |
3.80e-04 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 42.56 E-value: 3.80e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 130 IAMCFLVRVMDAVSFAAAMTASSSILAKAFPNN-VATVLGSLETFSGLGLILGPPVGGFLYQSFGYEVPFIV---LGCVV 205
Cdd:cd17503 84 LASLIIFRILQGFGGGVLIPLAQTILLRIYPPEkRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYInlpIGILA 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 206 LLMVP-LNMYILPNyesdpgeHSFWKLIalpkvgLIAFVINSLSSCFGFLdptLSLFVLEKFNLPAGYVGLVFLGMALSY 284
Cdd:cd17503 164 LLLAPlLDLRLFKD-------RNFTLGL------LLSFLLGLGLFGAMFL---LPLYLQNVLGYSAFESGLVLAPGGLAS 227
|
170 180 190
....*....|....*....|....*....|....*....
gi 16445357 285 AISSPLFGLLSDKRPPlrKWLLVFGNLITAGCYMLLGPV 323
Cdd:cd17503 228 AILSPLVGRLLDKFGP--RLLLLAGLLLLALGTLLLAFL 264
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
34-211 |
5.07e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 42.18 E-value: 5.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 34 VFVLISAASVNLGSMMCYSILGPFFPK-EAEKKGASNTIIGMIFGCFALFELLASLVFGNYLV-HIGAKFMFVAGMFVSG 111
Cdd:cd17330 173 LPPLRRLLLVYFLIALAFAGLESVFSLfLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAkRLGERKLLRLGLLLAI 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 112 gvtILFGVLDRVPDGPVFIAMCFLVRVMDAVsfaaAMTASSSILAKAFP-NNVATVLGSLETFSGLGLILGPPVGGFLYQ 190
Cdd:cd17330 253 ---IGLLLLPFASSVPLLVLAAAILAFGTGI----VFPALSALLSKSVPsKEQGKAQGIIQSLQSLARIIGPLLAGPLYS 325
|
170 180
....*....|....*....|.
gi 16445357 191 SFGYEVPFIVLGCVVLLMVPL 211
Cdd:cd17330 326 FLGPGVPFLLAAGLLLIALFL 346
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
35-422 |
8.81e-04 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 41.44 E-value: 8.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 35 FVLISAASVNLGSMMCYSiLGPFFPKEAEKKGASNTIIGMIFGCFALFELLASLVFGNYLVHIGAKFMFVAGMFVSGGVT 114
Cdd:cd17353 4 LVLLGAVLMHLILGYQYA-WSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGF 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 115 ILFGVldrvpdGPVFIAMCFLVRVMDAVSFAAAMTASSSILAKAFPNNVATVLGSLETFSGLGLILGPPVGGFLYQSFGY 194
Cdd:cd17353 83 ILSAF------AISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 195 EVPFIVLGCVVLLMVPLNMYIL----------------PNYESDPGEHSFWKLIALPKVGLIAFVINSLSSCFGFLDPTL 258
Cdd:cd17353 157 PTTFLILGIIFLIIIVIGAFLIrdppkgwvppgvdplaNNAENSPRDYTPREMLRTPTFWLLWLMFFLNATAGLMLIGQA 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 259 SLFVLEKFNLPAGYVGLVFLGMALSYAISSPLFGLLSDKRPPLRKWLLVFgnLITAGCYMLLGPVPILHIksqlwlLVLI 338
Cdd:cd17353 237 KPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAF--LIQGVAMFLLPFIGSVAV------LFVL 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 339 LVVSGLSAGMSIIPTFPEILScaheNGFeeGLSTLGLVSGLFSAMWSIGAFMGPTLGGFLYEKIGFEWAAAIQGLWALIS 418
Cdd:cd17353 309 GVALIGFCYGGGFALFPALTA----DFF--GTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVA 382
|
....
gi 16445357 419 GLAM 422
Cdd:cd17353 383 LALA 386
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
51-216 |
1.30e-03 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 41.06 E-value: 1.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 51 YSILGPFFPKEAEKKG-----ASNTIIGMIFGCFALFELLASLVFGNYLVHIGAKFMFVAGMFVSGGVTILFGVLDRVPD 125
Cdd:PRK09874 30 FSLVMPFLPLYVEQLGvtghsALNMWSGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLAQNIWQ 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 126 GPVFIAMCFLVrvmdavsfAAAMTASSSILAKAFPNNVAT-VLGSLETFSGLGLILGPPVGGFLYQSFGYEVPFIVLGCV 204
Cdd:PRK09874 110 FLILRALLGLL--------GGFVPNANALIATQVPRNKSGwALGTLSTGGVSGALLGPLAGGLLADSYGLRPVFFITASV 181
|
170
....*....|..
gi 16445357 205 VLLMVPLNMYIL 216
Cdd:PRK09874 182 LFLCFLVTLFCI 193
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
251-428 |
1.92e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 40.27 E-value: 1.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 251 FGFLDPTLSLFVLEKFNLPAGYVGLVFLGMALSYAISSPLFGLLSDKRPPL---RKWLLVFGNLITAGCYMLLGPVPILH 327
Cdd:COG2211 26 FGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRwgrRRPWILIGAIPLALSFVLLFTAPDLS 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 328 IKSQLWLLVLILVVSGLSAGMSIIPT---FPEILSCAHEngfeeglstLGLVSGLFSAMWSIGAFMGPTLGGFLYEKIGF 404
Cdd:COG2211 106 PTGKLIYALVTYLLLGLAYTLVNIPYsalGAELTPDYEE---------RTRLSSWRFAFAGLGGLLASVLPPPLVAAFGG 176
|
170 180
....*....|....*....|....
gi 16445357 405 EWAAAIQgLWALISGLAMGLFYLL 428
Cdd:COG2211 177 DAALGYR-LTALIFAVLGLLAFLL 199
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
52-417 |
2.69e-03 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 40.00 E-value: 2.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 52 SILGPFFPKEAekkGASNTIIGMIFGCFALFELLASLVFGNYLVHIGAKFMFVAGMFVSGGVTILFGVldrVPDGPVFIA 131
Cdd:cd17333 16 GILGPSLEEAF---NLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFA---TPSIYLFVV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 132 MCFLVrvmdAVSFAAAMTASSSILAKAFPNNVATVLGSLETFSGLGLILGPPVGG-FLYQSFGYEVPFIVLGCVVLLMV- 209
Cdd:cd17333 90 LMFLA----GLGAGILDTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATsLLTSELSWSWAYLIIGLIYLLLAi 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 210 ----PLNMYILPNYESDPGEHSFWKLIA----LPKVGLIAFVI----NSLSSCFGFldptLSLFVLEKFNLPAGYVGLVF 277
Cdd:cd17333 166 lillTLFPELPSARNPQQSVGAFSASASrllrNPSIILGALALflyvGAETAFSSW----VPSYLVEKKHVSDGLAGYLL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 278 LGMALSYAISSPLFGLLSDKrppLRKWLLVFGNLITAgcymLLGPVPILHIKSQLWLLVLILVVsglsaGMSIIPTFPEI 357
Cdd:cd17333 242 SGFWVGITIGRLLGGPISRR---IKPHTLLVLSGSGA----LLGLLILLLAPTLVVGLVATALL-----GLFMAALFPTI 309
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 358 LSCAHENGFEEGlstlGLVSGLFSAMWSIGAFMGPTLGGFLYEKIGFEWAAAIQGLWALI 417
Cdd:cd17333 310 LSLGISNLPYAK----GKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAI 365
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
35-425 |
3.65e-03 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 39.48 E-value: 3.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 35 FVLISAASVnlgSMMCYSILGPFFPK-EAEKKGASNTIIGMIFGCFALFELLASLVFGNYLVHIGAKFMFVAGMFVSGgv 113
Cdd:cd17473 2 ITLLLASTL---TVMAGAAIAPALPAiAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYG-- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 114 tiLFGVLdrvpdgPVF---IAMCFLVRVMDAVSFAAAMTASSSILAKAFPNNV-ATVLGSLETFSGLGLILGPPVGGFLy 189
Cdd:cd17473 77 --IGGVA------GLFldsLYALLASRALLGIGVAGIMTLATALIGDYFEGEErAKMLGLQSAAMSLGGVVFLLLGGAL- 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 190 QSFGYEVPFIVLGcVVLLMVPLNMYILP----NYESDPGEHSFWKLIALPKVGLIAFVINSLSSCFGFLDPT-LSLFVLE 264
Cdd:cd17473 148 AEIGWRAPFLVYL-LALPVLILVLLFLPeparKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIqLPFLLQE 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 265 KFNLPAGYVGLVFLGMALSYAISSPLFGLLSDKRPPLRKWLLVFgnLITAGCYMLLGPVPILhiksqlWLLVLILVVSGL 344
Cdd:cd17473 227 RGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGF--ALMALGFLLLALASGL------WVVLLGAILAGL 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 345 SAGMSIIPTFPEILSCAHEngfeeglSTLGLVSGLFSAMWSIGAFMGPTLGGFLYEKIGFEWAA-AIQGLWALISGLAMG 423
Cdd:cd17473 299 GFGLLLPTLNSWAMSLVPP-------ELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAfLILGVLALVLAIVLL 371
|
..
gi 16445357 424 LF 425
Cdd:cd17473 372 LL 373
|
|
| MFS_1_like |
pfam12832 |
MFS_1 like family; This family contains proteins related to the MFS superfamily. |
3-200 |
4.68e-03 |
|
MFS_1 like family; This family contains proteins related to the MFS superfamily.
Pssm-ID: 432817 [Multi-domain] Cd Length: 362 Bit Score: 39.15 E-value: 4.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 3 ALGDLEGPRAPGGDDPAGSAGETPGWLSREQVFVLISAASVNLgsmMCYSILGPFFPKEAEKKGASNTIIGMIFGCFALF 82
Cdd:pfam12832 172 SLLLPLAPPEMEYESKGGSKAVFWNLLKQPEVIIFFLAAFLLG---FSHGPFYTFLFLYLENLGASNTLLGALWALGVVA 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445357 83 ELLASLVFGNYLVHIGAKFMFVAGMFVSGgvtILFGVLDRVPDGPVFiamCFLVRVMDAVSFAAAMTASSSILAKAFPNN 162
Cdd:pfam12832 249 EIPLFFYAHRLLRRFGHRNLLIIALLLTA---LRWLLYAFFVENPWL---VLPIQFLHAISFGLTHAAAIEYVRRIFPGS 322
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 16445357 163 VATVLGSLET--FSGLGLILGPPVGGFLYQSFGYEVPFIV 200
Cdd:pfam12832 323 LQGTGQALYSglYFGLGGALGSLIGGQLWDLFGARFTFRA 362
|
|
| |
