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Conserved domains on  [gi|145309298|ref|NP_443089|]
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zinc finger protein 830 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 10648429)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0003676|GO:0008270|GO:0003700
PubMed:  11179890|11361095|10940247|22803940|12665246
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 49-82 6.55e-05

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


:

Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 39.54  E-value: 6.55e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 145309298    49 GQLSCALCNTPVKSELLWQTHVLGKQHREKVAEL 82
Cdd:smart00451   2 GGFYCKLCNVTFTDEISVEAHLKGKKHKKNVKKR 35
COG4913 super family cl25907
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
226-364 3.47e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


The actual alignment was detected with superfamily member COG4913:

Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 42.59  E-value: 3.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145309298  226 IEKAEIHEKVVERRENTAEALPEGFFDD---PEVDARVRKVDAPKDQMDKEWDEFQKAMRQVNTISEAIVAEEDEEGRLD 302
Cdd:COG4913   633 LEALEAELDALQERREALQRLAEYSWDEidvASAEREIAELEAELERLDASSDDLAALEEQLEELEAELEELEEELDELK 712

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 145309298  303 RQIGEIDEQIE-CYRRVEKLRNRQDEIkNKLKEILTIKELQKKEEENADSDDEGELQDLLSQD 364
Cdd:COG4913   713 GEIGRLEKELEqAEEELDELQDRLEAA-EDLARLELRALLEERFAAALGDAVERELRENLEER 774
 
Name Accession Description Interval E-value
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 49-82 6.55e-05

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 39.54  E-value: 6.55e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 145309298    49 GQLSCALCNTPVKSELLWQTHVLGKQHREKVAEL 82
Cdd:smart00451   2 GGFYCKLCNVTFTDEISVEAHLKGKKHKKNVKKR 35
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
226-364 3.47e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 42.59  E-value: 3.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145309298  226 IEKAEIHEKVVERRENTAEALPEGFFDD---PEVDARVRKVDAPKDQMDKEWDEFQKAMRQVNTISEAIVAEEDEEGRLD 302
Cdd:COG4913   633 LEALEAELDALQERREALQRLAEYSWDEidvASAEREIAELEAELERLDASSDDLAALEEQLEELEAELEELEEELDELK 712

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 145309298  303 RQIGEIDEQIE-CYRRVEKLRNRQDEIkNKLKEILTIKELQKKEEENADSDDEGELQDLLSQD 364
Cdd:COG4913   713 GEIGRLEKELEqAEEELDELQDRLEAA-EDLARLELRALLEERFAAALGDAVERELRENLEER 774
zf-met pfam12874
Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found ...
 51-75 1.26e-03

Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found in multiple copies in a wide range of proteins from plants to metazoans. Some member proteins, particularly those from plants, are annotated as being RNA-binding.


Pssm-ID: 463736 [Multi-domain]  Cd Length: 25  Bit Score: 35.93  E-value: 1.26e-03
                          10        20
                  ....*....|....*....|....*
gi 145309298   51 LSCALCNTPVKSELLWQTHVLGKQH 75
Cdd:pfam12874   1 FYCELCNVTFNSESQLKSHLQGKKH 25
PRP11 COG5246
Splicing factor 3a, subunit 2 [RNA processing and modification];
18-80 1.52e-03

Splicing factor 3a, subunit 2 [RNA processing and modification];


Pssm-ID: 227571 [Multi-domain]  Cd Length: 222  Bit Score: 39.66  E-value: 1.52e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 145309298  18 QEELRRLMKEKQRLStsrkriESPFAKYNRLGQLSCALCNTPVKSELLWQTHVLGKQHREKVA 80
Cdd:COG5246   27 RSRQLLLEAYGQDLM------DDPYLSKNHTGKYVCLLCKTKHLTEMSYVKHREGKKHKENSS 83
 
Name Accession Description Interval E-value
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 49-82 6.55e-05

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 39.54  E-value: 6.55e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 145309298    49 GQLSCALCNTPVKSELLWQTHVLGKQHREKVAEL 82
Cdd:smart00451   2 GGFYCKLCNVTFTDEISVEAHLKGKKHKKNVKKR 35
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
226-364 3.47e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 42.59  E-value: 3.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145309298  226 IEKAEIHEKVVERRENTAEALPEGFFDD---PEVDARVRKVDAPKDQMDKEWDEFQKAMRQVNTISEAIVAEEDEEGRLD 302
Cdd:COG4913   633 LEALEAELDALQERREALQRLAEYSWDEidvASAEREIAELEAELERLDASSDDLAALEEQLEELEAELEELEEELDELK 712

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 145309298  303 RQIGEIDEQIE-CYRRVEKLRNRQDEIkNKLKEILTIKELQKKEEENADSDDEGELQDLLSQD 364
Cdd:COG4913   713 GEIGRLEKELEqAEEELDELQDRLEAA-EDLARLELRALLEERFAAALGDAVERELRENLEER 774
zf-met pfam12874
Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found ...
 51-75 1.26e-03

Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found in multiple copies in a wide range of proteins from plants to metazoans. Some member proteins, particularly those from plants, are annotated as being RNA-binding.


Pssm-ID: 463736 [Multi-domain]  Cd Length: 25  Bit Score: 35.93  E-value: 1.26e-03
                          10        20
                  ....*....|....*....|....*
gi 145309298   51 LSCALCNTPVKSELLWQTHVLGKQH 75
Cdd:pfam12874   1 FYCELCNVTFNSESQLKSHLQGKKH 25
PRP11 COG5246
Splicing factor 3a, subunit 2 [RNA processing and modification];
18-80 1.52e-03

Splicing factor 3a, subunit 2 [RNA processing and modification];


Pssm-ID: 227571 [Multi-domain]  Cd Length: 222  Bit Score: 39.66  E-value: 1.52e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 145309298  18 QEELRRLMKEKQRLStsrkriESPFAKYNRLGQLSCALCNTPVKSELLWQTHVLGKQHREKVA 80
Cdd:COG5246   27 RSRQLLLEAYGQDLM------DDPYLSKNHTGKYVCLLCKTKHLTEMSYVKHREGKKHKENSS 83
zf-C2H2_jaz pfam12171
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, ...
 50-76 2.77e-03

Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.


Pssm-ID: 432381 [Multi-domain]  Cd Length: 27  Bit Score: 34.84  E-value: 2.77e-03
                          10        20
                  ....*....|....*....|....*..
gi 145309298   50 QLSCALCNTPVKSELLWQTHVLGKQHR 76
Cdd:pfam12171   1 QFYCVLCDKYFKSENALQNHLKSKKHK 27
PstA COG4985
ABC-type phosphate transport system, auxiliary component PstA [Inorganic ion transport and ...
 235-361 8.28e-03

ABC-type phosphate transport system, auxiliary component PstA [Inorganic ion transport and metabolism];


Pssm-ID: 444009 [Multi-domain]  Cd Length: 545  Bit Score: 37.98  E-value: 8.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145309298 235 VVERREN-TAEALPEGFFDDpevdarvrkvDAPKDQMDKEWDEFQKAMRQVNTISEAIvaeEDEEgrlDRQIGEIDEQIE 313
Cdd:COG4985  127 VLERREWgNFYGYLVAVKED----------GQVVAEGDAAWEELQQRLERALELRDQI---DDIE---KGDIGAINYQLE 190

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 145309298 314 CYRrvekLRNRQDEIKNKlkeiLTIKELQKKEEENADSDDE-GELQDLL 361
Cdd:COG4985  191 RLR----LKERRLELDGQ----LDDEAQADIEAERAELEAEyAVLEQQL 231
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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