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Conserved domains on  [gi|24119274|ref|NP_443099|]
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sodium leak channel NALCN isoform 2 [Homo sapiens]

Protein Classification

ion transporter( domain architecture ID 11997982)

ion transporter such as a voltage-gated cation channel, which enables the selective translocation of cations such as sodium, calcium, or potassium across cell membranes

CATH:  1.10.287.70
PubMed:  15816170
TCDB:  1.A.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
887-1161 3.85e-35

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 134.70  E-value: 3.85e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24119274    887 YLDWVMIIVTICSCISMMFESPFRRVMHAPT-LQIAEYVFVIFMSIELNLKIMADGLFFtptAVIRDFGGVMDIFIYLVS 965
Cdd:pfam00520    3 YFELFILLLILLNTIFLALETYFQPEEPLTTvLEILDYVFTGIFTLEMLLKIIAAGFKK---RYFRSPWNILDFVVVLPS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24119274    966 LIFLCWMPQNVPaeSGAQLLMVLRCLRPLRIFKLVPQMRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLak 1045
Cdd:pfam00520   80 LISLVLSSVGSL--SGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL-- 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24119274   1046 cndpniirredcngifrinvsvsknlnlklrpgekkpgfwvpRVWANP--RNFNFDNVGNAMLALFEVLSLKGWVEV-RD 1122
Cdd:pfam00520  156 ------------------------------------------KTWENPdnGRTNFDNFPNAFLWLFQTMTTEGWGDImYD 193
                          250       260       270
                   ....*....|....*....|....*....|....*....
gi 24119274   1123 VIIHRVGPIHGIYIHVFVFLGCMIGLTLFVGVVIANFNE 1161
Cdd:pfam00520  194 TIDGKGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQE 232
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
383-603 1.07e-33

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 130.85  E-value: 1.07e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24119274    383 SSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLaEVAFTVLFDLEALLKIWCLGFTG-YISSSLHKFELLLVIGT 461
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTTVLEIL-DYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24119274    462 TLHVYPDLYHSQ-----FTYFQVLRVVRLIKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVEELDR 536
Cdd:pfam00520   80 LISLVLSSVGSLsglrvLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWE 159
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24119274    537 --------FTTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWApvvAIYFILYHLFATLILLSLFVAVILDNLE 603
Cdd:pfam00520  160 npdngrtnFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEFWA---YIYFVSFIILGGFLLLNLFIAVIIDNFQ 231
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1209-1458 3.66e-32

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 126.23  E-value: 3.66e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24119274   1209 HPFFKRTIALLVLAQSVLLSVKWDVE--DPVTVPLATMSVVFTFIFVLEVTMKIIAMSPAG-FWQSRRNRYDLLVTSLGV 1285
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQpeEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24119274   1286 VWVVLHFALLNAYTYMMgACVIVFRFFSICGKHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFGTV--KYG 1363
Cdd:pfam00520   81 ISLVLSSVGSLSGLRVL-RLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKlkTWE 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24119274   1364 ENINRHANFSSAGKAITVLFRIVTGEDWNKIMHDCMVQPPfctpdeftywatdcgnYAGALMYFCSFYVIIAYIMLNLLV 1443
Cdd:pfam00520  160 NPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG----------------EFWAYIYFVSFIILGGFLLLNLFI 223
                          250
                   ....*....|....*
gi 24119274   1444 AIIVENFSLFYSTEE 1458
Cdd:pfam00520  224 AVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
36-331 1.43e-27

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 113.13  E-value: 1.43e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24119274     36 PWVHSLLRICAIISVISVCMNTPmtFEHYPPLQYVTFTLDTLLMFLYTAEMIAKMHIRGIVKgdsSYVKDRWCVFDGFMV 115
Cdd:pfam00520    2 RYFELFILLLILLNTIFLALETY--FQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKK---RYFRSPWNILDFVVV 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24119274    116 FCLWVSLVLqvfeiadivDQMSPWGMLRIPRPLIMIRAFRIYFRFELPRTRItNILKRSGEQIWSVSIFLLFFLLLYGIL 195
Cdd:pfam00520   77 LPSLISLVL---------SSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLV-NSLIRSLKSLGNLLLLLLLFLFIFAII 146
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24119274    196 GVQMFGTFTYhcvvNDTKPGNVTWNslaipdthcspeleegyqcppgfkcmdledlglsrqelgysgFNEIGTSIFTVYE 275
Cdd:pfam00520  147 GYQLFGGKLK----TWENPDNGRTN------------------------------------------FDNFPNAFLWLFQ 180
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 24119274    276 AASQEGWVFLMYRAIDSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIETFAEIRVQ 331
Cdd:pfam00520  181 TMTTEGWGDIMYDTIDGKGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTER 236
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
887-1161 3.85e-35

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 134.70  E-value: 3.85e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24119274    887 YLDWVMIIVTICSCISMMFESPFRRVMHAPT-LQIAEYVFVIFMSIELNLKIMADGLFFtptAVIRDFGGVMDIFIYLVS 965
Cdd:pfam00520    3 YFELFILLLILLNTIFLALETYFQPEEPLTTvLEILDYVFTGIFTLEMLLKIIAAGFKK---RYFRSPWNILDFVVVLPS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24119274    966 LIFLCWMPQNVPaeSGAQLLMVLRCLRPLRIFKLVPQMRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLak 1045
Cdd:pfam00520   80 LISLVLSSVGSL--SGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL-- 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24119274   1046 cndpniirredcngifrinvsvsknlnlklrpgekkpgfwvpRVWANP--RNFNFDNVGNAMLALFEVLSLKGWVEV-RD 1122
Cdd:pfam00520  156 ------------------------------------------KTWENPdnGRTNFDNFPNAFLWLFQTMTTEGWGDImYD 193
                          250       260       270
                   ....*....|....*....|....*....|....*....
gi 24119274   1123 VIIHRVGPIHGIYIHVFVFLGCMIGLTLFVGVVIANFNE 1161
Cdd:pfam00520  194 TIDGKGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQE 232
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
383-603 1.07e-33

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 130.85  E-value: 1.07e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24119274    383 SSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLaEVAFTVLFDLEALLKIWCLGFTG-YISSSLHKFELLLVIGT 461
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTTVLEIL-DYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24119274    462 TLHVYPDLYHSQ-----FTYFQVLRVVRLIKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVEELDR 536
Cdd:pfam00520   80 LISLVLSSVGSLsglrvLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWE 159
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24119274    537 --------FTTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWApvvAIYFILYHLFATLILLSLFVAVILDNLE 603
Cdd:pfam00520  160 npdngrtnFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEFWA---YIYFVSFIILGGFLLLNLFIAVIIDNFQ 231
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1209-1458 3.66e-32

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 126.23  E-value: 3.66e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24119274   1209 HPFFKRTIALLVLAQSVLLSVKWDVE--DPVTVPLATMSVVFTFIFVLEVTMKIIAMSPAG-FWQSRRNRYDLLVTSLGV 1285
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQpeEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24119274   1286 VWVVLHFALLNAYTYMMgACVIVFRFFSICGKHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFGTV--KYG 1363
Cdd:pfam00520   81 ISLVLSSVGSLSGLRVL-RLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKlkTWE 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24119274   1364 ENINRHANFSSAGKAITVLFRIVTGEDWNKIMHDCMVQPPfctpdeftywatdcgnYAGALMYFCSFYVIIAYIMLNLLV 1443
Cdd:pfam00520  160 NPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG----------------EFWAYIYFVSFIILGGFLLLNLFI 223
                          250
                   ....*....|....*
gi 24119274   1444 AIIVENFSLFYSTEE 1458
Cdd:pfam00520  224 AVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
36-331 1.43e-27

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 113.13  E-value: 1.43e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24119274     36 PWVHSLLRICAIISVISVCMNTPmtFEHYPPLQYVTFTLDTLLMFLYTAEMIAKMHIRGIVKgdsSYVKDRWCVFDGFMV 115
Cdd:pfam00520    2 RYFELFILLLILLNTIFLALETY--FQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKK---RYFRSPWNILDFVVV 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24119274    116 FCLWVSLVLqvfeiadivDQMSPWGMLRIPRPLIMIRAFRIYFRFELPRTRItNILKRSGEQIWSVSIFLLFFLLLYGIL 195
Cdd:pfam00520   77 LPSLISLVL---------SSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLV-NSLIRSLKSLGNLLLLLLLFLFIFAII 146
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24119274    196 GVQMFGTFTYhcvvNDTKPGNVTWNslaipdthcspeleegyqcppgfkcmdledlglsrqelgysgFNEIGTSIFTVYE 275
Cdd:pfam00520  147 GYQLFGGKLK----TWENPDNGRTN------------------------------------------FDNFPNAFLWLFQ 180
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 24119274    276 AASQEGWVFLMYRAIDSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIETFAEIRVQ 331
Cdd:pfam00520  181 TMTTEGWGDIMYDTIDGKGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTER 236
PLN03223 PLN03223
Polycystin cation channel protein; Provisional
1336-1451 1.89e-05

Polycystin cation channel protein; Provisional


Pssm-ID: 215637 [Multi-domain]  Cd Length: 1634  Bit Score: 49.94  E-value: 1.89e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24119274  1336 FFIIVGMflLLLCYAFAGVVLFGtvkygeniNRHANFSSAGKAITVLFRIVTGeDWNKIMHDCMVqppfctpdeftywAT 1415
Cdd:PLN03223 1333 FFVIFGM--VFVGYAFIGHVIFG--------NASVHFSDMTDSINSLFENLLG-DITYFNEDLKN-------------LT 1388
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 24119274  1416 DCGNYAGALmYFCSFYVIIAYIMLNLLVAIIVENFS 1451
Cdd:PLN03223 1389 GLQFVVGMI-YFYSYNIFVFMILFNFLLAIICDAFG 1423
PLN03223 PLN03223
Polycystin cation channel protein; Provisional
537-600 6.05e-03

Polycystin cation channel protein; Provisional


Pssm-ID: 215637 [Multi-domain]  Cd Length: 1634  Bit Score: 41.47  E-value: 6.05e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24119274   537 FTTFPRAFMSMFQILTqeGWVDVMDQTLNAVGHMWAPVVAIYFILYHLFATLILLSLFVAVILD 600
Cdd:PLN03223 1359 FSDMTDSINSLFENLL--GDITYFNEDLKNLTGLQFVVGMIYFYSYNIFVFMILFNFLLAIICD 1420
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
887-1161 3.85e-35

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 134.70  E-value: 3.85e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24119274    887 YLDWVMIIVTICSCISMMFESPFRRVMHAPT-LQIAEYVFVIFMSIELNLKIMADGLFFtptAVIRDFGGVMDIFIYLVS 965
Cdd:pfam00520    3 YFELFILLLILLNTIFLALETYFQPEEPLTTvLEILDYVFTGIFTLEMLLKIIAAGFKK---RYFRSPWNILDFVVVLPS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24119274    966 LIFLCWMPQNVPaeSGAQLLMVLRCLRPLRIFKLVPQMRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLak 1045
Cdd:pfam00520   80 LISLVLSSVGSL--SGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL-- 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24119274   1046 cndpniirredcngifrinvsvsknlnlklrpgekkpgfwvpRVWANP--RNFNFDNVGNAMLALFEVLSLKGWVEV-RD 1122
Cdd:pfam00520  156 ------------------------------------------KTWENPdnGRTNFDNFPNAFLWLFQTMTTEGWGDImYD 193
                          250       260       270
                   ....*....|....*....|....*....|....*....
gi 24119274   1123 VIIHRVGPIHGIYIHVFVFLGCMIGLTLFVGVVIANFNE 1161
Cdd:pfam00520  194 TIDGKGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQE 232
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
383-603 1.07e-33

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 130.85  E-value: 1.07e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24119274    383 SSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLaEVAFTVLFDLEALLKIWCLGFTG-YISSSLHKFELLLVIGT 461
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTTVLEIL-DYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24119274    462 TLHVYPDLYHSQ-----FTYFQVLRVVRLIKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVEELDR 536
Cdd:pfam00520   80 LISLVLSSVGSLsglrvLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWE 159
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24119274    537 --------FTTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWApvvAIYFILYHLFATLILLSLFVAVILDNLE 603
Cdd:pfam00520  160 npdngrtnFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEFWA---YIYFVSFIILGGFLLLNLFIAVIIDNFQ 231
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1209-1458 3.66e-32

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 126.23  E-value: 3.66e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24119274   1209 HPFFKRTIALLVLAQSVLLSVKWDVE--DPVTVPLATMSVVFTFIFVLEVTMKIIAMSPAG-FWQSRRNRYDLLVTSLGV 1285
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQpeEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24119274   1286 VWVVLHFALLNAYTYMMgACVIVFRFFSICGKHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFGTV--KYG 1363
Cdd:pfam00520   81 ISLVLSSVGSLSGLRVL-RLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKlkTWE 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24119274   1364 ENINRHANFSSAGKAITVLFRIVTGEDWNKIMHDCMVQPPfctpdeftywatdcgnYAGALMYFCSFYVIIAYIMLNLLV 1443
Cdd:pfam00520  160 NPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG----------------EFWAYIYFVSFIILGGFLLLNLFI 223
                          250
                   ....*....|....*
gi 24119274   1444 AIIVENFSLFYSTEE 1458
Cdd:pfam00520  224 AVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
36-331 1.43e-27

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 113.13  E-value: 1.43e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24119274     36 PWVHSLLRICAIISVISVCMNTPmtFEHYPPLQYVTFTLDTLLMFLYTAEMIAKMHIRGIVKgdsSYVKDRWCVFDGFMV 115
Cdd:pfam00520    2 RYFELFILLLILLNTIFLALETY--FQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKK---RYFRSPWNILDFVVV 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24119274    116 FCLWVSLVLqvfeiadivDQMSPWGMLRIPRPLIMIRAFRIYFRFELPRTRItNILKRSGEQIWSVSIFLLFFLLLYGIL 195
Cdd:pfam00520   77 LPSLISLVL---------SSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLV-NSLIRSLKSLGNLLLLLLLFLFIFAII 146
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24119274    196 GVQMFGTFTYhcvvNDTKPGNVTWNslaipdthcspeleegyqcppgfkcmdledlglsrqelgysgFNEIGTSIFTVYE 275
Cdd:pfam00520  147 GYQLFGGKLK----TWENPDNGRTN------------------------------------------FDNFPNAFLWLFQ 180
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 24119274    276 AASQEGWVFLMYRAIDSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIETFAEIRVQ 331
Cdd:pfam00520  181 TMTTEGWGDIMYDTIDGKGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTER 236
PLN03223 PLN03223
Polycystin cation channel protein; Provisional
1336-1451 1.89e-05

Polycystin cation channel protein; Provisional


Pssm-ID: 215637 [Multi-domain]  Cd Length: 1634  Bit Score: 49.94  E-value: 1.89e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24119274  1336 FFIIVGMflLLLCYAFAGVVLFGtvkygeniNRHANFSSAGKAITVLFRIVTGeDWNKIMHDCMVqppfctpdeftywAT 1415
Cdd:PLN03223 1333 FFVIFGM--VFVGYAFIGHVIFG--------NASVHFSDMTDSINSLFENLLG-DITYFNEDLKN-------------LT 1388
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 24119274  1416 DCGNYAGALmYFCSFYVIIAYIMLNLLVAIIVENFS 1451
Cdd:PLN03223 1389 GLQFVVGMI-YFYSYNIFVFMILFNFLLAIICDAFG 1423
PLN03223 PLN03223
Polycystin cation channel protein; Provisional
537-600 6.05e-03

Polycystin cation channel protein; Provisional


Pssm-ID: 215637 [Multi-domain]  Cd Length: 1634  Bit Score: 41.47  E-value: 6.05e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24119274   537 FTTFPRAFMSMFQILTqeGWVDVMDQTLNAVGHMWAPVVAIYFILYHLFATLILLSLFVAVILD 600
Cdd:PLN03223 1359 FSDMTDSINSLFENLL--GDITYFNEDLKNLTGLQFVVGMIYFYSYNIFVFMILFNFLLAIICD 1420
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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