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Conserved domains on  [gi|53829385|ref|NP_443120|]
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leucine-rich repeat-containing protein 37B isoform 1 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRRC37AB_C pfam14914
LRRC37A/B like protein 1 C-terminal domain; This family represents the C-terminal domain of ...
 793-937 3.26e-61

LRRC37A/B like protein 1 C-terminal domain; This family represents the C-terminal domain of the putative Leucine Rich Repeat Containing protein 37A or protein 37B (LRRC37A/B) found in eukaryotes. The Leucine Rich Repeats (LRR) lies in the central region. The gene that encodes this protein is found in the chromosomal position 17q11.2, and its microdeletion results in the disease, neurofibromatosis type-1 (NF1). The function of the protein, LRRC37B is unknown, however experimental data shows expression in the aorta, heart, skeletal muscle, liver and brain during gestation.


:

Pssm-ID: 464370  Cd Length: 147  Bit Score: 204.58  E-value: 3.26e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385   793 FGGDQLEIQLTEQLRSLIPNEDVRKFMSHVIRTLKMECSETHVQGSCAKLMLRTGLLMKLLSEQQEAKALNVEWDTDQQK 872
Cdd:pfam14914   1 SPGDQFEIQLNQQLLSLIPNVDVRRLISHVIRTLKMDCSEPQMQLACAKLISRTGLLMKLLSEQQEAKVSKADWDTDQWK 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 53829385   873 T-NYINENME-QNEQKEQKSSELMKEVPGDDYKNKLIFAISVTVILIILIIIFCLIEVNSHKRASEK 937
Cdd:pfam14914  81 NeNYINESTEaQSKQKKQSSRELTKEVPGYGYNNKLILAISVTVVIMILIIILCLIEICSHRSASGE 147
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 359-437 5.62e-19

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


:

Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 82.03  E-value: 5.62e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 53829385   359 ETESTQAQQEAPIQPPEEAEPSSTalrttdPPPEHPEVTLPPSDKGQAQHSHLTEATVQPLDLELSITTEPTTEVKPSP 437
Cdd:pfam15779   1 EVEPSPTQQETPTQPPESPKEVVA------QPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 294-363 2.17e-18

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


:

Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 80.10  E-value: 2.17e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 53829385   294 EVEPS-TQQEAPALPPESSMESLAQTPLNHEVTVQPPGEDQAHY-NLPKFTVKPADVEVTMTSEPKNETEST 363
Cdd:pfam15779   1 EVEPSpTQQETPTQPPESPKEVVAQPPVHHEVTVPTPGQGQAQHpTLPNVTVQPLDLELTITPEPTKEAEHS 72
LRR_8 pfam13855
Leucine rich repeat;
582-639 2.32e-13

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 65.62  E-value: 2.32e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 53829385   582 EKLILSENYLTELPKDSFEGLLYLQYLDLSCNKIRYIERQTFESLPFLQYINLGCNLI 639
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
558-699 5.23e-12

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.81  E-value: 5.23e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385 558 TTLNFQGNYISYLDGNVWKAYSwTEKLILSENYLTELPkDSFEGLLYLQYLDLSCNKIRYIErQTFESLPFLQYINLGCN 637
Cdd:COG4886 162 KSLDLSNNQLTDLPEELGNLTN-LKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNN 238

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 53829385 638 LITKL-SLGTFQAwhgmqfLHNLILNRNPLTTVedPYLFELPALKYLDMGTTHITLTTLKNIL 699
Cdd:COG4886 239 QLTDLpELGNLTN------LEELDLSNNQLTDL--PPLANLTNLKTLDLSNNQLTDLKLKELE 293
PRK10263 super family cl35903
DNA translocase FtsK; Provisional
 203-513 2.63e-05

DNA translocase FtsK; Provisional


The actual alignment was detected with superfamily member PRK10263:

Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 48.16  E-value: 2.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385   203 PEIVGIPHQLSKPQRQKQTLPDDYLSMDTLYPG--SLPP-----ELRVNADEP---PGPPEQVGLSQFHLEPKSQ----- 267
Cdd:PRK10263  344 PPVASVDVPPAQPTVAWQPVPGPQTGEPVIAPApeGYPQqsqyaQPAVQYNEPlqqPVQPQQPYYAPAAEQPAQQpyyap 423

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385   268 NPETLEDIQSSSLQEEAPAQLLQLPQEVEPSTQQEAPALPPESS-MESLAQTPLNHevtvQPPGEDQAHYNLPKFTV--- 343
Cdd:PRK10263  424 APEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQTEQTyQQPAAQEPLYQ----QPQPVEQQPVVEPEPVVeet 499

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385   344 KPADVEVTMTSEPKNETESTQAQQEA-------PIQPPEEAEPSSTALRTTDPPPEHPEVTLPPSDKG--QAQHSHLTEA 414
Cdd:PRK10263  500 KPARPPLYYFEEVEEKRAREREQLAAwyqpipePVKEPEPIKSSLKAPSVAAVPPVEAAAAVSPLASGvkKATLATGAAA 579

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385   415 TVQPLDLELSITTEPTTEVKpspttEETSAQPPDPGLAITPE-----------PTTEIGHSTALEKTRAPHPDQVQTLHR 483
Cdd:PRK10263  580 TVAAPVFSLANSGGPRPQVK-----EGIGPQLPRPKRIRVPTrrelasygiklPSQRAAEEKAREAQRNQYDSGDQYNDD 654

                         330       340       350
                  ....*....|....*....|....*....|
gi 53829385   484 SLTEVtgpptklesSQDSLVQSETAPEEQK 513
Cdd:PRK10263  655 EIDAM---------QQDELARQFAQTQQQR 675
 
Name Accession Description Interval E-value
LRRC37AB_C pfam14914
LRRC37A/B like protein 1 C-terminal domain; This family represents the C-terminal domain of ...
 793-937 3.26e-61

LRRC37A/B like protein 1 C-terminal domain; This family represents the C-terminal domain of the putative Leucine Rich Repeat Containing protein 37A or protein 37B (LRRC37A/B) found in eukaryotes. The Leucine Rich Repeats (LRR) lies in the central region. The gene that encodes this protein is found in the chromosomal position 17q11.2, and its microdeletion results in the disease, neurofibromatosis type-1 (NF1). The function of the protein, LRRC37B is unknown, however experimental data shows expression in the aorta, heart, skeletal muscle, liver and brain during gestation.


Pssm-ID: 464370  Cd Length: 147  Bit Score: 204.58  E-value: 3.26e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385   793 FGGDQLEIQLTEQLRSLIPNEDVRKFMSHVIRTLKMECSETHVQGSCAKLMLRTGLLMKLLSEQQEAKALNVEWDTDQQK 872
Cdd:pfam14914   1 SPGDQFEIQLNQQLLSLIPNVDVRRLISHVIRTLKMDCSEPQMQLACAKLISRTGLLMKLLSEQQEAKVSKADWDTDQWK 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 53829385   873 T-NYINENME-QNEQKEQKSSELMKEVPGDDYKNKLIFAISVTVILIILIIIFCLIEVNSHKRASEK 937
Cdd:pfam14914  81 NeNYINESTEaQSKQKKQSSRELTKEVPGYGYNNKLILAISVTVVIMILIIILCLIEICSHRSASGE 147
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 359-437 5.62e-19

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 82.03  E-value: 5.62e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 53829385   359 ETESTQAQQEAPIQPPEEAEPSSTalrttdPPPEHPEVTLPPSDKGQAQHSHLTEATVQPLDLELSITTEPTTEVKPSP 437
Cdd:pfam15779   1 EVEPSPTQQETPTQPPESPKEVVA------QPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 294-363 2.17e-18

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 80.10  E-value: 2.17e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 53829385   294 EVEPS-TQQEAPALPPESSMESLAQTPLNHEVTVQPPGEDQAHY-NLPKFTVKPADVEVTMTSEPKNETEST 363
Cdd:pfam15779   1 EVEPSpTQQETPTQPPESPKEVVAQPPVHHEVTVPTPGQGQAQHpTLPNVTVQPLDLELTITPEPTKEAEHS 72
LRR_8 pfam13855
Leucine rich repeat;
582-639 2.32e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 65.62  E-value: 2.32e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 53829385   582 EKLILSENYLTELPKDSFEGLLYLQYLDLSCNKIRYIERQTFESLPFLQYINLGCNLI 639
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
558-699 5.23e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.81  E-value: 5.23e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385 558 TTLNFQGNYISYLDGNVWKAYSwTEKLILSENYLTELPkDSFEGLLYLQYLDLSCNKIRYIErQTFESLPFLQYINLGCN 637
Cdd:COG4886 162 KSLDLSNNQLTDLPEELGNLTN-LKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNN 238

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 53829385 638 LITKL-SLGTFQAwhgmqfLHNLILNRNPLTTVedPYLFELPALKYLDMGTTHITLTTLKNIL 699
Cdd:COG4886 239 QLTDLpELGNLTN------LEELDLSNNQLTDL--PPLANLTNLKTLDLSNNQLTDLKLKELE 293
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 238-511 1.48e-06

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 52.38  E-value: 1.48e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385  238 PPELRVNADEPPGPPEQVGLSQFHLEPKSQNPETLEDIQSSSLQEEAPAQLLQLPQEVEPS---TQQEAPALP------- 307
Cdd:PTZ00449 510 PPEGPEASGLPPKAPGDKEGEEGEHEDSKESDEPKEGGKPGETKEGEVGKKPGPAKEHKPSkipTLSKKPEFPkdpkhpk 589

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385  308 -PESSMESlaQTPLNHEVTVQPPGEdqahyNLPKFTVKPadvevtmTSEPKNETESTQAQQEAPIQPPEEAEPSSTALRT 386
Cdd:PTZ00449 590 dPEEPKKP--KRPRSAQRPTRPKSP-----KLPELLDIP-------KSPKRPESPKSPKRPPPPQRPSSPERPEGPKIIK 655

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385  387 TDPPPEHPEVTLPPSDKGQAQHSHL-----TEATVQPLDLELSITTEPTTEVKPSPTTEETSAQPPDPGLAITPE-PTTE 460
Cdd:PTZ00449 656 SPKPPKSPKPPFDPKFKEKFYDDYLdaaakSKETKTTVVLDESFESILKETLPETPGTPFTTPRPLPPKLPRDEEfPFEP 735

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 53829385  461 IGHSTA-----LEKTRAPHPDQVQtLHRSLTEVTGPPTKLESSQDSLVQSET-APEE 511
Cdd:PTZ00449 736 IGDPDAeqpddIEFFTPPEEERTF-FHETPADTPLPDILAEEFKEEDIHAETgEPDE 791
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 203-513 2.63e-05

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 48.16  E-value: 2.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385   203 PEIVGIPHQLSKPQRQKQTLPDDYLSMDTLYPG--SLPP-----ELRVNADEP---PGPPEQVGLSQFHLEPKSQ----- 267
Cdd:PRK10263  344 PPVASVDVPPAQPTVAWQPVPGPQTGEPVIAPApeGYPQqsqyaQPAVQYNEPlqqPVQPQQPYYAPAAEQPAQQpyyap 423

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385   268 NPETLEDIQSSSLQEEAPAQLLQLPQEVEPSTQQEAPALPPESS-MESLAQTPLNHevtvQPPGEDQAHYNLPKFTV--- 343
Cdd:PRK10263  424 APEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQTEQTyQQPAAQEPLYQ----QPQPVEQQPVVEPEPVVeet 499

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385   344 KPADVEVTMTSEPKNETESTQAQQEA-------PIQPPEEAEPSSTALRTTDPPPEHPEVTLPPSDKG--QAQHSHLTEA 414
Cdd:PRK10263  500 KPARPPLYYFEEVEEKRAREREQLAAwyqpipePVKEPEPIKSSLKAPSVAAVPPVEAAAAVSPLASGvkKATLATGAAA 579

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385   415 TVQPLDLELSITTEPTTEVKpspttEETSAQPPDPGLAITPE-----------PTTEIGHSTALEKTRAPHPDQVQTLHR 483
Cdd:PRK10263  580 TVAAPVFSLANSGGPRPQVK-----EGIGPQLPRPKRIRVPTrrelasygiklPSQRAAEEKAREAQRNQYDSGDQYNDD 654

                         330       340       350
                  ....*....|....*....|....*....|
gi 53829385   484 SLTEVtgpptklesSQDSLVQSETAPEEQK 513
Cdd:PRK10263  655 EIDAM---------QQDELARQFAQTQQQR 675
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 203-458 5.92e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 47.07  E-value: 5.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385   203 PEIVGIPHQLSK---PQRQKQTLPDDYLSMDTLYPGSLPPELRVNADEPPGPPEQvgLSQFHLEPKSQNPETlediqsss 279
Cdd:pfam03154 295 PQPFPLTPQSSQsqvPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAP--LSMPHIKPPPTTPIP-------- 364

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385   280 lQEEAPAQLLQLPQEVEPSTQQEAPALPPESSMESLAQTPLNHEVTVQPPG---EDQAHYNLPKFTVKPADVEVTMTSEP 356
Cdd:pfam03154 365 -QLPNPQSHKHPPHLSGPSPFQMNSNLPPPPALKPLSSLSTHHPPSAHPPPlqlMPQSQQLPPPPAQPPVLTQSQSLPPP 443

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385   357 KNETESTQAQQEAPIQPPEEAEPSSTALRTTDPPPEHPEVTLPPSDKGQAQHSHLTEATVQPLDLELSiTTEPTTEVKPS 436
Cdd:pfam03154 444 AASHPPTSGLHQVPSQSPFPQHPFVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVS-CPLPPVQIKEE 522

                         250       260
                  ....*....|....*....|...
gi 53829385   437 PTTE-ETSAQPPDPGLAITPEPT 458
Cdd:pfam03154 523 ALDEaEEPESPPPPPRSPSPEPT 545
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 239-459 2.10e-03

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 41.68  E-value: 2.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385  239 PELRVNADEPPGPPEQVGLSQFHLEPKSQNPETLEDIQSSSLQEEAPAQLLQLPQEVEPSTQQEAPALP---PESSMESL 315
Cdd:NF033839 181 PSPQPEGKKPSVPDINQEKEKAKLAVATYMSKILDDIQKHHLQKEKHRQIVALIKELDELKKQALSEIDnvnTKVEIENT 260

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385  316 AQTPLNHEVTVQPPGEDQAHYNLPKFTVKPADVEVTMTSEPKNETESTQAQQEAPIQPPEEAEPSSTALRTTDPPPEHPE 395
Cdd:NF033839 261 VHKIFADMDAVVTKFKKGLTQDTPKEPGNKKPSAPKPGMQPSPQPEKKEVKPEPETPKPEVKPQLEKPKPEVKPQPEKPK 340

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 53829385  396 VTLPPSDKGQAQHSHLTEATVQPldlELSITTE-PTTEVKPSPTTE--ETSAQPPDPGLAITPEPTT 459
Cdd:NF033839 341 PEVKPQLETPKPEVKPQPEKPKP---EVKPQPEkPKPEVKPQPETPkpEVKPQPEKPKPEVKPQPEK 404
SepH NF040712
septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces ...
 295-457 5.13e-03

septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.


Pssm-ID: 468676 [Multi-domain]  Cd Length: 346  Bit Score: 40.14  E-value: 5.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385  295 VEPSTQQEAPALPPESSMESLAQTPLNHEVTVQPPGEDqahynlpkftvKPADVEVTMTSEPKNETESTQAQQEAPIQPP 374
Cdd:NF040712 188 IDPDFGRPLRPLATVPRLAREPADARPEEVEPAPAAEG-----------APATDSDPAEAGTPDDLASARRRRAGVEQPE 256

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385  375 EEaEPSSTALRTTDPPPEHPEVTLPPSDkgqaQHSHLTEATVQPldlelsittePTTEVKPSPTTEETSAQPPDPGLAIT 454
Cdd:NF040712 257 DE-PVGPGAAPAAEPDEATRDAGEPPAP----GAAETPEAAEPP----------APAPAAPAAPAAPEAEEPARPEPPPA 321


                 ...
gi 53829385  455 PEP 457
Cdd:NF040712 322 PKP 324
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 294-520 5.17e-03

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 40.52  E-value: 5.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385  294 EVEPSTQQEAPALPPEssmeslAQTPlNHEVTVQPPGedqahynlPKFTVKPADVEVTMTSEPKNETESTQA--QQEAP- 370
Cdd:NF033839 298 GMQPSPQPEKKEVKPE------PETP-KPEVKPQLEK--------PKPEVKPQPEKPKPEVKPQLETPKPEVkpQPEKPk 362

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385  371 --IQP-PEEAEPSSTALRTTDPPPEHPEVTLPPSDKGQAQHSHLTEATVQPldlelsitTEPTTEVKPSPTT--EETSAQ 445
Cdd:NF033839 363 peVKPqPEKPKPEVKPQPETPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQP--------EKPKPEVKPQPEKpkPEVKPQ 434

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 53829385  446 PPDPGLAITPEPTTEighstalEKTRAPHPDQVQTLHRSLTEVTGPPTKLESSQDSLVQSETAPEEQKASTSTNI 520
Cdd:NF033839 435 PEKPKPEVKPQPEKP-------KPEVKPQPETPKPEVKPQPEKPKPEVKPQPEKPKPDNSKPQADDKKPSTPNNL 502
DamX COG3266
Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell ...
 234-481 6.44e-03

Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442497 [Multi-domain]  Cd Length: 455  Bit Score: 40.22  E-value: 6.44e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385 234 PGSLPPELRVNADEPPGPPEQVGLSQFHLEPKSQNPETLEDIQSSSLQEEAPAQLLQLPQEVEPSTQQEAPALPPESSME 313
Cdd:COG3266 129 LLVLLLLLALLLALLLDLPLLTLLIVLPLLEEQLLLLALQDIQGTLQALGAVAALLGLRKAEEALALRAGSAAADALALL 208

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385 314 SLAQTPLNHEVTvqppgedQAHYNLPKFTVKPADVEVTMTSEPKNETESTQAQQEAPIQPPEEAEPSSTALRTTDPPPEH 393
Cdd:COG3266 209 LLLLASALGEAV-------AAAAELAALALLAAGAAEVLTARLVLLLLIIGSALKAPSQASSASAPATTSLGEQQEVSLP 281

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385 394 PEVTLPPSDKGQAQHSHLTEATVQPldlELSITTEPTTEVKPSPTTEETSAQPPDPglAITPEPTTEIGHST-ALEKTRA 472
Cdd:COG3266 282 PAVAAQPAAAAAAQPSAVALPAAPA---AAAAAAAPAEAAAPQPTAAKPVVTETAA--PAAPAPEAAAAAAApAAPAVAK 356


                ....*....
gi 53829385 473 PHPDQVQTL 481
Cdd:COG3266 357 KLAADEQWL 365
 
Name Accession Description Interval E-value
LRRC37AB_C pfam14914
LRRC37A/B like protein 1 C-terminal domain; This family represents the C-terminal domain of ...
 793-937 3.26e-61

LRRC37A/B like protein 1 C-terminal domain; This family represents the C-terminal domain of the putative Leucine Rich Repeat Containing protein 37A or protein 37B (LRRC37A/B) found in eukaryotes. The Leucine Rich Repeats (LRR) lies in the central region. The gene that encodes this protein is found in the chromosomal position 17q11.2, and its microdeletion results in the disease, neurofibromatosis type-1 (NF1). The function of the protein, LRRC37B is unknown, however experimental data shows expression in the aorta, heart, skeletal muscle, liver and brain during gestation.


Pssm-ID: 464370  Cd Length: 147  Bit Score: 204.58  E-value: 3.26e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385   793 FGGDQLEIQLTEQLRSLIPNEDVRKFMSHVIRTLKMECSETHVQGSCAKLMLRTGLLMKLLSEQQEAKALNVEWDTDQQK 872
Cdd:pfam14914   1 SPGDQFEIQLNQQLLSLIPNVDVRRLISHVIRTLKMDCSEPQMQLACAKLISRTGLLMKLLSEQQEAKVSKADWDTDQWK 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 53829385   873 T-NYINENME-QNEQKEQKSSELMKEVPGDDYKNKLIFAISVTVILIILIIIFCLIEVNSHKRASEK 937
Cdd:pfam14914  81 NeNYINESTEaQSKQKKQSSRELTKEVPGYGYNNKLILAISVTVVIMILIIILCLIEICSHRSASGE 147
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 359-437 5.62e-19

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 82.03  E-value: 5.62e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 53829385   359 ETESTQAQQEAPIQPPEEAEPSSTalrttdPPPEHPEVTLPPSDKGQAQHSHLTEATVQPLDLELSITTEPTTEVKPSP 437
Cdd:pfam15779   1 EVEPSPTQQETPTQPPESPKEVVA------QPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 294-363 2.17e-18

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 80.10  E-value: 2.17e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 53829385   294 EVEPS-TQQEAPALPPESSMESLAQTPLNHEVTVQPPGEDQAHY-NLPKFTVKPADVEVTMTSEPKNETEST 363
Cdd:pfam15779   1 EVEPSpTQQETPTQPPESPKEVVAQPPVHHEVTVPTPGQGQAQHpTLPNVTVQPLDLELTITPEPTKEAEHS 72
LRR_8 pfam13855
Leucine rich repeat;
582-639 2.32e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 65.62  E-value: 2.32e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 53829385   582 EKLILSENYLTELPKDSFEGLLYLQYLDLSCNKIRYIERQTFESLPFLQYINLGCNLI 639
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
558-699 5.23e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.81  E-value: 5.23e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385 558 TTLNFQGNYISYLDGNVWKAYSwTEKLILSENYLTELPkDSFEGLLYLQYLDLSCNKIRYIErQTFESLPFLQYINLGCN 637
Cdd:COG4886 162 KSLDLSNNQLTDLPEELGNLTN-LKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNN 238

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 53829385 638 LITKL-SLGTFQAwhgmqfLHNLILNRNPLTTVedPYLFELPALKYLDMGTTHITLTTLKNIL 699
Cdd:COG4886 239 QLTDLpELGNLTN------LEELDLSNNQLTDL--PPLANLTNLKTLDLSNNQLTDLKLKELE 293
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
582-710 1.15e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.57  E-value: 1.15e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385 582 EKLILSENYLTELPkDSFEGLLYLQYLDLSCNKIRYIERQtFESLPFLQYINLGCNLITKLSlgtfQAWHGMQFLHNLIL 661
Cdd:COG4886 116 ESLDLSGNQLTDLP-EELANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDLP----EELGNLTNLKELDL 189

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 53829385 662 NRNPLTTVEDPyLFELPALKYLDMGTTHIT-----LTTLKNiltmtveLEKLIL 710
Cdd:COG4886 190 SNNQITDLPEP-LGNLTNLEELDLSGNQLTdlpepLANLTN-------LETLDL 235
LRR_8 pfam13855
Leucine rich repeat;
605-666 6.12e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.61  E-value: 6.12e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 53829385   605 LQYLDLSCNKIRYIERQTFESLPFLQYINLGCNLITKLSLGTFQAWHGMQFLHnliLNRNPL 666
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLD---LSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
550-710 7.41e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 52.63  E-value: 7.41e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385 550 PDTYNGIFTTLNFQGNYISYLDGNVWKAYSWTEKLILSENyltelpkDSFEGLLYLQYLDLSCNKIRYIErQTFESLPFL 629
Cdd:COG4886  67 LLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLP-EELANLTNL 138

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385 630 QYINLGCNLITKL--SLGTFQAwhgmqfLHNLILNRNPLTTVEDPyLFELPALKYLDMGTTHItlTTLKNILTMTVELEK 707
Cdd:COG4886 139 KELDLSNNQLTDLpePLGNLTN------LKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQI--TDLPEPLGNLTNLEE 209


                ...
gi 53829385 708 LIL 710
Cdd:COG4886 210 LDL 212
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 238-511 1.48e-06

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 52.38  E-value: 1.48e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385  238 PPELRVNADEPPGPPEQVGLSQFHLEPKSQNPETLEDIQSSSLQEEAPAQLLQLPQEVEPS---TQQEAPALP------- 307
Cdd:PTZ00449 510 PPEGPEASGLPPKAPGDKEGEEGEHEDSKESDEPKEGGKPGETKEGEVGKKPGPAKEHKPSkipTLSKKPEFPkdpkhpk 589

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385  308 -PESSMESlaQTPLNHEVTVQPPGEdqahyNLPKFTVKPadvevtmTSEPKNETESTQAQQEAPIQPPEEAEPSSTALRT 386
Cdd:PTZ00449 590 dPEEPKKP--KRPRSAQRPTRPKSP-----KLPELLDIP-------KSPKRPESPKSPKRPPPPQRPSSPERPEGPKIIK 655

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385  387 TDPPPEHPEVTLPPSDKGQAQHSHL-----TEATVQPLDLELSITTEPTTEVKPSPTTEETSAQPPDPGLAITPE-PTTE 460
Cdd:PTZ00449 656 SPKPPKSPKPPFDPKFKEKFYDDYLdaaakSKETKTTVVLDESFESILKETLPETPGTPFTTPRPLPPKLPRDEEfPFEP 735

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 53829385  461 IGHSTA-----LEKTRAPHPDQVQtLHRSLTEVTGPPTKLESSQDSLVQSET-APEE 511
Cdd:PTZ00449 736 IGDPDAeqpddIEFFTPPEEERTF-FHETPADTPLPDILAEEFKEEDIHAETgEPDE 791
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
558-699 1.02e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 49.16  E-value: 1.02e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385 558 TTLNFQGNYISYLDGNVwKAYSWTEKLILSENYLTELPkdSFEGLLYLQYLDLSCNKIRYIErqTFESLPFLQYINLGCN 637
Cdd:COG4886 208 EELDLSGNQLTDLPEPL-ANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNN 282

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 53829385 638 LITKLSLGTFQAWHGMQFLHNLILNRNPLTTVEDPYLFELPALKYLDMGTTHITLTTLKNIL 699
Cdd:COG4886 283 QLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSL 344
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 304-517 1.12e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 49.38  E-value: 1.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385   304 PALPPESSMESLAQTPLNHEVTVQPPGEDQAHYNLPKFTVKPADVEVTMTSEPKNETESTQA----QQEAPIQPPEEAEP 379
Cdd:pfam03154 110 PNSPSEGEGESSDGRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQILQTQPpvlqAQSGAASPPSPPPP 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385   380 SSTALRTTDPPPEHPEVTLPPSdKGQAQHSHLTEATVQPLDLelsITTEPTTEVK--PSPTTEETSAQPPDPGLAITPEP 457
Cdd:pfam03154 190 GTTQAATAGPTPSAPSVPPQGS-PATSQPPNQTQSTAAPHTL---IQQTPTLHPQrlPSPHPPLQPMTQPPPPSQVSPQP 265

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 53829385   458 TTE---------IGHSTALEKTRAPHPDQVQ--TLHRSLTEVTGPPTKLESSQDSLVQSETAPEEQKASTS 517
Cdd:pfam03154 266 LPQpslhgqmppMPHSLQTGPSHMQHPVPPQpfPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQS 336
rne PRK10811
ribonuclease E; Reviewed
 292-478 2.38e-05

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 48.50  E-value: 2.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385   292 PQEVEPSTQQEAPALPPessmeslaqTPLNHEVTVQPPGEDqahynlpkftVKPADVEVTMTSEPKnETESTQAQQEAPI 371
Cdd:PRK10811  850 PQDVQVEEQREAEEVQV---------QPVVAEVPVAAAVEP----------VVSAPVVEAVAEVVE-EPVVVAEPQPEEV 909

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385   372 QPPEEAEPSSTAlrttDPPPEHPEVTLPPSDKGQAQHSHLTEATVQPLDLELSITTEPTTE--------------VKPSP 437
Cdd:PRK10811  910 VVVETTHPEVIA----APVTEQPQVITESDVAVAQEVAEHAEPVVEPQDETADIEEAAETAevvvaepevvaqpaAPVVA 985

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 53829385   438 TTEETSAQPPDPGLAITPEPTTEIG----HSTAlEKTRAPHPDQV 478
Cdd:PRK10811  986 EVAAEVETVTAVEPEVAPAQVPEATvehnHATA-PMTRAPAPEYV 1029
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 203-513 2.63e-05

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 48.16  E-value: 2.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385   203 PEIVGIPHQLSKPQRQKQTLPDDYLSMDTLYPG--SLPP-----ELRVNADEP---PGPPEQVGLSQFHLEPKSQ----- 267
Cdd:PRK10263  344 PPVASVDVPPAQPTVAWQPVPGPQTGEPVIAPApeGYPQqsqyaQPAVQYNEPlqqPVQPQQPYYAPAAEQPAQQpyyap 423

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385   268 NPETLEDIQSSSLQEEAPAQLLQLPQEVEPSTQQEAPALPPESS-MESLAQTPLNHevtvQPPGEDQAHYNLPKFTV--- 343
Cdd:PRK10263  424 APEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQTEQTyQQPAAQEPLYQ----QPQPVEQQPVVEPEPVVeet 499

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385   344 KPADVEVTMTSEPKNETESTQAQQEA-------PIQPPEEAEPSSTALRTTDPPPEHPEVTLPPSDKG--QAQHSHLTEA 414
Cdd:PRK10263  500 KPARPPLYYFEEVEEKRAREREQLAAwyqpipePVKEPEPIKSSLKAPSVAAVPPVEAAAAVSPLASGvkKATLATGAAA 579

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385   415 TVQPLDLELSITTEPTTEVKpspttEETSAQPPDPGLAITPE-----------PTTEIGHSTALEKTRAPHPDQVQTLHR 483
Cdd:PRK10263  580 TVAAPVFSLANSGGPRPQVK-----EGIGPQLPRPKRIRVPTrrelasygiklPSQRAAEEKAREAQRNQYDSGDQYNDD 654

                         330       340       350
                  ....*....|....*....|....*....|
gi 53829385   484 SLTEVtgpptklesSQDSLVQSETAPEEQK 513
Cdd:PRK10263  655 EIDAM---------QQDELARQFAQTQQQR 675
PHA03247 PHA03247
large tegument protein UL36; Provisional
 234-517 2.80e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.40  E-value: 2.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385   234 PGSLPP---ELRVNADEPPGPPEqvglsqfhlePKSQNPETLEDIQSSSLQEEAPAQLLQLPQEVEPSTQQEAPALPPES 310
Cdd:PHA03247 2685 RRAARPtvgSLTSLADPPPPPPT----------PEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGP 2754

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385   311 SMESLAQTPLNHEVTVQPPGEDQAhynlPKFTVKPADVEVTMTSEPKNETESTQAQQEAPIQPPEEAEPSSTALRTTDPP 390
Cdd:PHA03247 2755 ARPARPPTTAGPPAPAPPAAPAAG----PPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPP 2830

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385   391 PEHPEVTLPPSDKGQAQHSHLTEATVQPLDlelSITTEPTTevKPSPTTEETSAQPPDPGLAI-TPEPTTEighSTALEK 469
Cdd:PHA03247 2831 PTSAQPTAPPPPPGPPPPSLPLGGSVAPGG---DVRRRPPS--RSPAAKPAAPARPPVRRLARpAVSRSTE---SFALPP 2902

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 53829385   470 TRAPHPDQVQTLHRSLTEVTGPPTKLESSQD---SLVQSETAPEEQKASTS 517
Cdd:PHA03247 2903 DQPERPPQPQAPPPPQPQPQPPPPPQPQPPPpppPRPQPPLAPTTDPAGAG 2953
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 203-458 5.92e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 47.07  E-value: 5.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385   203 PEIVGIPHQLSK---PQRQKQTLPDDYLSMDTLYPGSLPPELRVNADEPPGPPEQvgLSQFHLEPKSQNPETlediqsss 279
Cdd:pfam03154 295 PQPFPLTPQSSQsqvPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAP--LSMPHIKPPPTTPIP-------- 364

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385   280 lQEEAPAQLLQLPQEVEPSTQQEAPALPPESSMESLAQTPLNHEVTVQPPG---EDQAHYNLPKFTVKPADVEVTMTSEP 356
Cdd:pfam03154 365 -QLPNPQSHKHPPHLSGPSPFQMNSNLPPPPALKPLSSLSTHHPPSAHPPPlqlMPQSQQLPPPPAQPPVLTQSQSLPPP 443

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385   357 KNETESTQAQQEAPIQPPEEAEPSSTALRTTDPPPEHPEVTLPPSDKGQAQHSHLTEATVQPLDLELSiTTEPTTEVKPS 436
Cdd:pfam03154 444 AASHPPTSGLHQVPSQSPFPQHPFVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVS-CPLPPVQIKEE 522

                         250       260
                  ....*....|....*....|...
gi 53829385   437 PTTE-ETSAQPPDPGLAITPEPT 458
Cdd:pfam03154 523 ALDEaEEPESPPPPPRSPSPEPT 545
ECM1 pfam05782
Extracellular matrix protein 1 (ECM1); This family consists of several eukaryotic ...
 247-412 1.52e-04

Extracellular matrix protein 1 (ECM1); This family consists of several eukaryotic extracellular matrix protein 1 (ECM1) sequences. ECM1 has been shown to regulate endochondral bone formation, stimulate the proliferation of endothelial cells and induce angiogenesis. Mutations in the ECM1 gene can cause lipoid proteinosis, a disorder which causes generalized thickening of skin, mucosae and certain viscera. Classical features include beaded eyelid papules and laryngeal infiltration leading to hoarseness.


Pssm-ID: 461739  Cd Length: 518  Bit Score: 45.60  E-value: 1.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385   247 EPPGPPEQVGLSQFHLEPKSQNP--ETLEDIQSSSLQEEAPAQLLQLPQEVEPSTQQEAPALPPESSMESLAQTPLNHEV 324
Cdd:pfam05782   5 APPSPPQTRGLPVDHPDTSQHDPpfEGQSEVQPPPSQEAIPVQEEELPPPQLPVEKKVDPPLPQEAIPLQEELPPPQLPI 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385   325 ---TVQPPGEDQAHYNLPKFT-VKPADVEVTMTSEPKNETESTQAQQEAPIQ---------PPeeAEPSSTALRTTdPPP 391
Cdd:pfam05782  85 eqkEIDPPFPQQEEITPSKQReEKPAPLVGQGHPEPESWNPAQHCQQGRRRGgwghrldgfPP--GRPSPDNLNQI-CLP 161

                         170       180
                  ....*....|....*....|.
gi 53829385   392 EHPEVTLPPSDKGQAQHSHLT 412
Cdd:pfam05782 162 ERQHVVYGPWNLPQTGYSHLS 182
Pneumo_att_G pfam05539
Pneumovirinae attachment membrane glycoprotein G;
353-511 6.06e-04

Pneumovirinae attachment membrane glycoprotein G;


Pssm-ID: 114270 [Multi-domain]  Cd Length: 408  Bit Score: 43.50  E-value: 6.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385   353 TSEPKNETESTQAQQEAP-IQPPEEAEPSSTAL------------RTTDPPPEHPEVTLPPSDKGQAQHSHLTEATVQPL 419
Cdd:pfam05539 178 TSWPTEVSHPTYPSQVTPqSQPATQGHQTATANqrlsstepvgtqGTTTSSNPEPQTEPPPSQRGPSGSPQHPPSTTSQD 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385   420 dlelSITTEPTTEVKPSPTTEETSAQPPDPGLAITPEPTTEIghstalEKTRAPHPDQVQTLHRSLTEVTGPPT---KLE 496
Cdd:pfam05539 258 ----QSTTGDGQEHTQRRKTPPATSNRRSPHSTATPPPTTKR------QETGRPTPRPTATTQSGSSPPHSSPPgvqANP 327

                         170
                  ....*....|....*
gi 53829385   497 SSQDSLVQSETAPEE 511
Cdd:pfam05539 328 TTQNLVDCKELDPPK 342
PHA03247 PHA03247
large tegument protein UL36; Provisional
 44-509 7.21e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 7.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385    44 PPEPWSSRSSHLPWESPHAPAPPAAPGDFDylGPSASSQMSALPQEPTENLAPflkeldsagelPLGPEPFLAAHQDLND 123
Cdd:PHA03247 2577 PSEPAVTSRARRPDAPPQSARPRAPVDDRG--DPRGPAPPSPLPPDTHAPDPP-----------PPSPSPAANEPDPHPP 2643

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385   124 KRTPEERLPEVVPLLNRdqnqalVQLPRlkwvQTTDLDRAAGHQadeilvpldSKVSRPTkfvvspknlkkdlaeRWSLP 203
Cdd:PHA03247 2644 PTVPPPERPRDDPAPGR------VSRPR----RARRLGRAAQAS---------SPPQRPR---------------RRAAR 2689

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385   204 EIVGIPHQLSKPQRQKQTlpddylsmdtlyPGSLPPELRVNADEPPGPpeQVGLSQFHLEPKSQNPETLEDIQSSSLQEE 283
Cdd:PHA03247 2690 PTVGSLTSLADPPPPPPT------------PEPAPHALVSATPLPPGP--AAARQASPALPAAPAPPAVPAGPATPGGPA 2755

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385   284 APAQLlQLPQEVEPSTQQEAPALPPESSMESLAQTPLNHEVTVQPPGEDQAHYNLPkftVKPADVEVTMTSEPKN-ETES 362
Cdd:PHA03247 2756 RPARP-PTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAA---VLAPAAALPPAASPAGpLPPP 2831

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385   363 TQAQQEAPIQPPEEAEPSSTALRTTDP-------PPEHPEVTLPPSDK-------GQAQHSHLTEATVQPLD-LELSITT 427
Cdd:PHA03247 2832 TSAQPTAPPPPPGPPPPSLPLGGSVAPggdvrrrPPSRSPAAKPAAPArppvrrlARPAVSRSTESFALPPDqPERPPQP 2911

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385   428 EPTTEVKPSPTTE---ETSAQPPDPGLAITPEPTTEIGHSTALEKTRAPHPdqvQTLHRSLTEVTGPPTKLESSQDSLVQ 504
Cdd:PHA03247 2912 QAPPPPQPQPQPPpppQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQP---WLGALVPGRVAVPRFRVPQPAPSREA 2988


                  ....*
gi 53829385   505 SETAP 509
Cdd:PHA03247 2989 PASST 2993
PHA03247 PHA03247
large tegument protein UL36; Provisional
 27-451 8.91e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.39  E-value: 8.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385    27 PLVWVKDPLQLTSNPLGPPEPWSSRSSHLPWESPHAPAPPAAPGDfdyLGPSASSQMSALPQEPTENLAPFLKELDSAGE 106
Cdd:PHA03247 2694 SLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAA---PAPPAVPAGPATPGGPARPARPPTTAGPPAPA 2770

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385   107 LPLGPepflAAHQDLNDKRTPEERLPEVVPLLNRDQNQALVQLPRLKWVQTTDLDRAAGHQADEILVPLDSKVSRPTKFV 186
Cdd:PHA03247 2771 PPAAP----AAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPP 2846

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385   187 VSPKNLkkdlaERWSLPeivGIPHQLSKPQRQKQTLPDdylsmdtlyPGSLPPELRVNADEPPGPPEQVGLSQFHLEPKS 266
Cdd:PHA03247 2847 PPSLPL-----GGSVAP---GGDVRRRPPSRSPAAKPA---------APARPPVRRLARPAVSRSTESFALPPDQPERPP 2909

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385   267 QNPetlediqssslqeeAPAQllQLPQEVEPSTQQEAPALPPessmESLAQTPLNHEVTVQPPGEDQAHYNLPKF-TVKP 345
Cdd:PHA03247 2910 QPQ--------------APPP--PQPQPQPPPPPQPQPPPPP----PPRPQPPLAPTTDPAGAGEPSGAVPQPWLgALVP 2969

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385   346 ADVEVTMTSEPKNeTESTQAQQEAPIQPPEEAEP------SSTALRT-TDPPPEHPEVTL-PPSDKGQAQHSHLTEATVQ 417
Cdd:PHA03247 2970 GRVAVPRFRVPQP-APSREAPASSTPPLTGHSLSrvsswaSSLALHEeTDPPPVSLKQTLwPPDDTEDSDADSLFDSDSE 3048

                         410       420       430
                  ....*....|....*....|....*....|....
gi 53829385   418 PLDLElSITTEPTTEVKPsptteetSAQPPDPGL 451
Cdd:PHA03247 3049 RSDLE-ALDPLPPEPHDP-------FAHEPDPAT 3074
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 239-459 2.10e-03

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 41.68  E-value: 2.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385  239 PELRVNADEPPGPPEQVGLSQFHLEPKSQNPETLEDIQSSSLQEEAPAQLLQLPQEVEPSTQQEAPALP---PESSMESL 315
Cdd:NF033839 181 PSPQPEGKKPSVPDINQEKEKAKLAVATYMSKILDDIQKHHLQKEKHRQIVALIKELDELKKQALSEIDnvnTKVEIENT 260

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385  316 AQTPLNHEVTVQPPGEDQAHYNLPKFTVKPADVEVTMTSEPKNETESTQAQQEAPIQPPEEAEPSSTALRTTDPPPEHPE 395
Cdd:NF033839 261 VHKIFADMDAVVTKFKKGLTQDTPKEPGNKKPSAPKPGMQPSPQPEKKEVKPEPETPKPEVKPQLEKPKPEVKPQPEKPK 340

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 53829385  396 VTLPPSDKGQAQHSHLTEATVQPldlELSITTE-PTTEVKPSPTTE--ETSAQPPDPGLAITPEPTT 459
Cdd:NF033839 341 PEVKPQLETPKPEVKPQPEKPKP---EVKPQPEkPKPEVKPQPETPkpEVKPQPEKPKPEVKPQPEK 404
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 605-643 3.70e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.07  E-value: 3.70e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 53829385   605 LQYLDLSCNKIRYIErqTFESLPFLQYINL-GCNLITKLS 643
Cdd:pfam12799   3 LEVLDLSNNQITDIP--PLAKLPNLETLDLsGNNKITDLS 40
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 432-496 4.01e-03

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 36.96  E-value: 4.01e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 53829385   432 EVKPSPTTEETSAQPPDPglaitpePTTEIGHSTALEKTRAPHPDQVQTLHRSLTEVTGPPTKLE 496
Cdd:pfam15779   1 EVEPSPTQQETPTQPPES-------PKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLE 58
SepH NF040712
septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces ...
 295-457 5.13e-03

septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.


Pssm-ID: 468676 [Multi-domain]  Cd Length: 346  Bit Score: 40.14  E-value: 5.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385  295 VEPSTQQEAPALPPESSMESLAQTPLNHEVTVQPPGEDqahynlpkftvKPADVEVTMTSEPKNETESTQAQQEAPIQPP 374
Cdd:NF040712 188 IDPDFGRPLRPLATVPRLAREPADARPEEVEPAPAAEG-----------APATDSDPAEAGTPDDLASARRRRAGVEQPE 256

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385  375 EEaEPSSTALRTTDPPPEHPEVTLPPSDkgqaQHSHLTEATVQPldlelsittePTTEVKPSPTTEETSAQPPDPGLAIT 454
Cdd:NF040712 257 DE-PVGPGAAPAAEPDEATRDAGEPPAP----GAAETPEAAEPP----------APAPAAPAAPAAPEAEEPARPEPPPA 321


                 ...
gi 53829385  455 PEP 457
Cdd:NF040712 322 PKP 324
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 294-520 5.17e-03

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 40.52  E-value: 5.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385  294 EVEPSTQQEAPALPPEssmeslAQTPlNHEVTVQPPGedqahynlPKFTVKPADVEVTMTSEPKNETESTQA--QQEAP- 370
Cdd:NF033839 298 GMQPSPQPEKKEVKPE------PETP-KPEVKPQLEK--------PKPEVKPQPEKPKPEVKPQLETPKPEVkpQPEKPk 362

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385  371 --IQP-PEEAEPSSTALRTTDPPPEHPEVTLPPSDKGQAQHSHLTEATVQPldlelsitTEPTTEVKPSPTT--EETSAQ 445
Cdd:NF033839 363 peVKPqPEKPKPEVKPQPETPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQP--------EKPKPEVKPQPEKpkPEVKPQ 434

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 53829385  446 PPDPGLAITPEPTTEighstalEKTRAPHPDQVQTLHRSLTEVTGPPTKLESSQDSLVQSETAPEEQKASTSTNI 520
Cdd:NF033839 435 PEKPKPEVKPQPEKP-------KPEVKPQPETPKPEVKPQPEKPKPEVKPQPEKPKPDNSKPQADDKKPSTPNNL 502
DamX COG3266
Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell ...
 234-481 6.44e-03

Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442497 [Multi-domain]  Cd Length: 455  Bit Score: 40.22  E-value: 6.44e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385 234 PGSLPPELRVNADEPPGPPEQVGLSQFHLEPKSQNPETLEDIQSSSLQEEAPAQLLQLPQEVEPSTQQEAPALPPESSME 313
Cdd:COG3266 129 LLVLLLLLALLLALLLDLPLLTLLIVLPLLEEQLLLLALQDIQGTLQALGAVAALLGLRKAEEALALRAGSAAADALALL 208

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385 314 SLAQTPLNHEVTvqppgedQAHYNLPKFTVKPADVEVTMTSEPKNETESTQAQQEAPIQPPEEAEPSSTALRTTDPPPEH 393
Cdd:COG3266 209 LLLLASALGEAV-------AAAAELAALALLAAGAAEVLTARLVLLLLIIGSALKAPSQASSASAPATTSLGEQQEVSLP 281

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385 394 PEVTLPPSDKGQAQHSHLTEATVQPldlELSITTEPTTEVKPSPTTEETSAQPPDPglAITPEPTTEIGHST-ALEKTRA 472
Cdd:COG3266 282 PAVAAQPAAAAAAQPSAVALPAAPA---AAAAAAAPAEAAAPQPTAAKPVVTETAA--PAAPAPEAAAAAAApAAPAVAK 356


                ....*....
gi 53829385 473 PHPDQVQTL 481
Cdd:COG3266 357 KLAADEQWL 365
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
282-475 7.20e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 40.24  E-value: 7.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385  282 EEAPAQLLQLP-QEVEPSTQQEAPALPPESSMESLAQTPLNHEVTVQPPGEDQAHYNLPKFTVKPADVEVTMTSEPKNET 360
Cdd:PRK12323 371 GAGPATAAAAPvAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAP 450

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829385  361 ESTQAQQEAPIQPPEEAEP-SSTALRTTDPPPEHPEVTLPPSDKGQAQHSHLTEATVQPldlELSITTEPTTEVKPSPTT 439
Cdd:PRK12323 451 APAPAAAPAAAARPAAAGPrPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASP---APAQPDAAPAGWVAESIP 527

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 53829385  440 EETSAQPPDPGLAITPEPTTeighSTALEKTRAPHP 475
Cdd:PRK12323 528 DPATADPDDAFETLAPAPAA----APAPRAAAATEP 559
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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