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Conserved domains on  [gi|116268101|ref|NP_443138|]
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protein phosphatase 1 regulatory subunit 29 precursor [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
60-205 3.15e-16

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.90  E-value: 3.15e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116268101  60 LRLNENKLKAvLYSSLNRFGNLTDLNLTKNEISYIedGAFLGQ-SSLQVLQLGYNKLSNLTEGmLRGMSRLQFLFVQHNL 138
Cdd:COG4886  118 LDLSGNQLTD-LPEELANLTNLKELDLSNNQLTDL--PEPLGNlTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQ 193

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 116268101 139 IEVVtPTAFSECPSLISIDLSSNRLSRLDgATFASLASLMVCELAGNPFNCECDLFGF--LAWLVVFNN 205
Cdd:COG4886  194 ITDL-PEPLGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDLPELGNLtnLEELDLSNN 260
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
60-205 3.15e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.90  E-value: 3.15e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116268101  60 LRLNENKLKAvLYSSLNRFGNLTDLNLTKNEISYIedGAFLGQ-SSLQVLQLGYNKLSNLTEGmLRGMSRLQFLFVQHNL 138
Cdd:COG4886  118 LDLSGNQLTD-LPEELANLTNLKELDLSNNQLTDL--PEPLGNlTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQ 193

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 116268101 139 IEVVtPTAFSECPSLISIDLSSNRLSRLDgATFASLASLMVCELAGNPFNCECDLFGF--LAWLVVFNN 205
Cdd:COG4886  194 ITDL-PEPLGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDLPELGNLtnLEELDLSNN 260
LRR_8 pfam13855
Leucine rich repeat;
80-139 9.38e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 66.39  E-value: 9.38e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 116268101   80 NLTDLNLTKNEISYIEDGAFLGQSSLQVLQLGYNKLSNLTEGMLRGMSRLQFLFVQHNLI 139
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 157-227 3.06e-07

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 54.32  E-value: 3.06e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 116268101   157 DLSSNRLSRLDGATFASLASLMVCELAGNPFNCECDLFGFLAWLVVFNNVTKNYDRLQCESPREFAGYPLL 227
Cdd:TIGR00864    1 DISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAALCAGPGALAGQPLL 71
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 60-187 3.02e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.01  E-value: 3.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116268101  60 LRLNENKLKA-----------VLY---------SSLNRFGNLTDLNLTKNEISYIEDgaFLGQSSLQVLQLGYNK----- 114
Cdd:cd21340    7 LYLNDKNITKidnlslcknlkVLYlydnkitkiENLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRisvve 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116268101 115 ----LSNLTE------------------GMLRGMSR-LQFLFVQHNLIEVVTPtaFSECPSLISIDLSSNRLSRLD--GA 169
Cdd:cd21340   85 glenLTNLEElhienqrlppgekltfdpRSLAALSNsLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEelLD 162

                        170
                 ....*....|....*...
gi 116268101 170 TFASLASLMVCELAGNPF 187
Cdd:cd21340  163 LLSSWPSLRELDLTGNPV 180
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 60-188 2.80e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.92  E-value: 2.80e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116268101  60 LRLNENKLKAVLYSSLnRFGNLTDLNLTKNEISYIEDGAFLGQSSLQVLQLGYNKLSNLTEGMLRGMSRLQFLFVQHNLI 139
Cdd:PLN00113 457 LSLARNKFFGGLPDSF-GSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQL 535

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 116268101 140 EVVTPTAFSECPSLISIDLSSNRLSRLDGATFASLASLMVCELAGNPFN 188
Cdd:PLN00113 536 SGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHLH 584
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
60-205 3.15e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.90  E-value: 3.15e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116268101  60 LRLNENKLKAvLYSSLNRFGNLTDLNLTKNEISYIedGAFLGQ-SSLQVLQLGYNKLSNLTEGmLRGMSRLQFLFVQHNL 138
Cdd:COG4886  118 LDLSGNQLTD-LPEELANLTNLKELDLSNNQLTDL--PEPLGNlTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQ 193

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 116268101 139 IEVVtPTAFSECPSLISIDLSSNRLSRLDgATFASLASLMVCELAGNPFNCECDLFGF--LAWLVVFNN 205
Cdd:COG4886  194 ITDL-PEPLGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDLPELGNLtnLEELDLSNN 260
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
60-214 3.82e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 75.36  E-value: 3.82e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116268101  60 LRLNENKLKaVLYSSLNRFGNLTDLNLTKNEISYIedGAFLGQ-SSLQVLQLGYNKLSNLTEGmLRGMSRLQFLFVQHNL 138
Cdd:COG4886  164 LDLSNNQLT-DLPEELGNLTNLKELDLSNNQITDL--PEPLGNlTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQ 239

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 116268101 139 IEVVTptAFSECPSLISIDLSSNRLSRLDgaTFASLASLMVCELAGNPFNcECDLFGFLAWLVVFNNVTKNYDRLQ 214
Cdd:COG4886  240 LTDLP--ELGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQLT-DLKLKELELLLGLNSLLLLLLLLNL 310
LRR_8 pfam13855
Leucine rich repeat;
80-139 9.38e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 66.39  E-value: 9.38e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 116268101   80 NLTDLNLTKNEISYIEDGAFLGQSSLQVLQLGYNKLSNLTEGMLRGMSRLQFLFVQHNLI 139
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
39-197 4.82e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 65.73  E-value: 4.82e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116268101  39 CSQNQppYETIPQHINSTVH--DLRLNENKLKAvLYSSLNRFGNLTDLNLTKNEISYIEDGafLGQ-SSLQVLQLGYNKL 115
Cdd:COG4886  166 LSNNQ--LTDLPEELGNLTNlkELDLSNNQITD-LPEPLGNLTNLEELDLSGNQLTDLPEP--LANlTNLETLDLSNNQL 240

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116268101 116 SNLTEgmLRGMSRLQFLFVQHNLIEVVTPTAfsECPSLISIDLSSNRLSRLDGATFASLASLMVCELAGNPFNCECDLFG 195
Cdd:COG4886  241 TDLPE--LGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLIL 316


                 ..
gi 116268101 196 FL 197
Cdd:COG4886  317 LL 318
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
40-188 3.14e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 63.03  E-value: 3.14e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116268101  40 SQNQPPYETIPQHINSTVHDLRLNENKLKAVLYSSLNRFGNLTDLNLTKNEisyiedgAFLGQSSLQVLQLGYNKLSNLT 119
Cdd:COG4886   57 LRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLP 129

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 116268101 120 EGmLRGMSRLQFLFVQHNLIEVVtPTAFSECPSLISIDLSSNRLSRLDgATFASLASLMVCELAGNPFN 188
Cdd:COG4886  130 EE-LANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQIT 195
LRR_8 pfam13855
Leucine rich repeat;
127-187 1.49e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.45  E-value: 1.49e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 116268101  127 SRLQFLFVQHNLIEVVTPTAFSECPSLISIDLSSNRLSRLDGATFASLASLMVCELAGNPF 187
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 157-227 3.06e-07

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 54.32  E-value: 3.06e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 116268101   157 DLSSNRLSRLDGATFASLASLMVCELAGNPFNCECDLFGFLAWLVVFNNVTKNYDRLQCESPREFAGYPLL 227
Cdd:TIGR00864    1 DISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAALCAGPGALAGQPLL 71
LRR_8 pfam13855
Leucine rich repeat;
55-115 2.31e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 2.31e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 116268101   55 STVHDLRLNENKLKAVLYSSLNRFGNLTDLNLTKNEISYIEDGAFLGQSSLQVLQLGYNKL 115
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 60-187 3.02e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.01  E-value: 3.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116268101  60 LRLNENKLKA-----------VLY---------SSLNRFGNLTDLNLTKNEISYIEDgaFLGQSSLQVLQLGYNK----- 114
Cdd:cd21340    7 LYLNDKNITKidnlslcknlkVLYlydnkitkiENLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRisvve 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116268101 115 ----LSNLTE------------------GMLRGMSR-LQFLFVQHNLIEVVTPtaFSECPSLISIDLSSNRLSRLD--GA 169
Cdd:cd21340   85 glenLTNLEElhienqrlppgekltfdpRSLAALSNsLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEelLD 162

                        170
                 ....*....|....*...
gi 116268101 170 TFASLASLMVCELAGNPF 187
Cdd:cd21340  163 LLSSWPSLRELDLTGNPV 180
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 60-188 2.80e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.92  E-value: 2.80e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116268101  60 LRLNENKLKAVLYSSLnRFGNLTDLNLTKNEISYIEDGAFLGQSSLQVLQLGYNKLSNLTEGMLRGMSRLQFLFVQHNLI 139
Cdd:PLN00113 457 LSLARNKFFGGLPDSF-GSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQL 535

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 116268101 140 EVVTPTAFSECPSLISIDLSSNRLSRLDGATFASLASLMVCELAGNPFN 188
Cdd:PLN00113 536 SGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHLH 584
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 75-165 8.50e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.78  E-value: 8.50e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116268101  75 LNRFGNLTDLNLTKNEIS--------------YIED-----G---AFLGQS------SLQVLQLGYNKLSNLTEgmLRGM 126
Cdd:cd21340   64 LENLVNLKKLYLGGNRISvveglenltnleelHIENqrlppGeklTFDPRSlaalsnSLRVLNISGNNIDSLEP--LAPL 141

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 116268101 127 SRLQFLFVQHNLIEVVTPTA--FSECPSLISIDLSSNRLSR 165
Cdd:cd21340  142 RNLEQLDASNNQISDLEELLdlLSSWPSLRELDLTGNPVCK 182
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 60-187 2.81e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.45  E-value: 2.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116268101  60 LRLNENKLKAVLYSSLNRFGNLTDLNLTKNEISYiEDGAFLGQ-SSLQVLQLGYNKLSNLTEGMLRGMSRLQFLFVQHNL 138
Cdd:PLN00113 193 LTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSG-EIPYEIGGlTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNK 271

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 116268101 139 IEVVTPTAFSECPSLISIDLSSNRLSRLDGATFASLASLMVCELAGNPF 187
Cdd:PLN00113 272 LSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNF 320
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 60-228 1.21e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.53  E-value: 1.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116268101  60 LRLNENKLKAVLYSSLNRFGNLTDLNLTKNEISYIEDGAFLGQSSLQVLQLGYNKLS-NLTEgmLRGMSRLQFLFVQHNL 138
Cdd:PLN00113 409 VRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFgGLPD--SFGSKRLENLDLSRNQ 486

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116268101 139 IEVVTPTAFSECPSLISIDLSSNRLSRLDGATFASLASLMVCELAGNPFNCECDLfGFlAWLVVFNNVTKNYDRLQCESP 218
Cdd:PLN00113 487 FSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPA-SF-SEMPVLSQLDLSQNQLSGEIP 564

                        170
                 ....*....|
gi 116268101 219 REFAGYPLLV 228
Cdd:PLN00113 565 KNLGNVESLV 574
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 54-190 3.35e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.42  E-value: 3.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116268101  54 NSTVHDLRLNENKLK----AVLYSSLNRFGNLTDLNLTKNEISYIED----GAFLGQSSLQVLQLGYNKLSN-----LTE 120
Cdd:cd00116  164 NRDLKELNLANNGIGdagiRALAEGLKANCNLEVLDLNNNGLTDEGAsalaETLASLKSLEVLNLGDNNLTDagaaaLAS 243

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 116268101 121 GMLRGMSRLQFLFVQHNLIEVVTPTAFSEC----PSLISIDLSSNRLS-RLDGATFASLASLMVCELAGNPFNCE 190
Cdd:cd00116  244 ALLSPNISLLTLSLSCNDITDDGAKDLAEVlaekESLLELDLRGNKFGeEGAQLLAESLLEPGNELESLWVKDDS 318
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 80-161 5.07e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 37.91  E-value: 5.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116268101   80 NLTDLNLTKNeISYIEDGAFLGQSSLQVLQLGynklSNLTE-GmlrgmsrlQFLFVQHNLIEVVTPT--------AFSEC 150
Cdd:pfam13306  12 SLTSITIPSS-LTSIGEYAFSNCTSLKSITLP----SSLTSiG--------SYAFYNCSLTSITIPSsltsigeyAFSNC 78

                          90
                  ....*....|.
gi 116268101  151 PSLISIDLSSN 161
Cdd:pfam13306  79 SNLKSITLPSN 89
PLN03150 PLN03150
hypothetical protein; Provisional
 39-146 5.20e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.18  E-value: 5.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116268101  39 CSQNQPPYETIPQHINST-----VHDLRLNENKLKAVLYSSLNRFGNLTDLNLTKNEISYIEDGAFLGQSSLQVLQLGYN 113
Cdd:PLN03150 397 CVPQQHPWSGADCQFDSTkgkwfIDGLGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYN 476

                         90       100       110
                 ....*....|....*....|....*....|...
gi 116268101 114 KLSNLTEGMLRGMSRLQFLFVQHNLIEVVTPTA 146
Cdd:PLN03150 477 SFNGSIPESLGQLTSLRILNLNGNSLSGRVPAA 509
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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