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Conserved domains on  [gi|16445033|ref|NP_443189|]
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germ cell nuclear acidic protein [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SprT smart00731
SprT homologues; Predicted to have roles in transcription elongation. Contains a conserved ...
519-677 3.45e-43

SprT homologues; Predicted to have roles in transcription elongation. Contains a conserved HExxH motif, indicating a metalloprotease function.


:

Pssm-ID: 214794 [Multi-domain]  Cd Length: 146  Bit Score: 152.48  E-value: 3.45e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445033    519 DELVQRIYDlFNRSVCDKKLPEKlRIGWNNKMVKTAGLCSTgemwypkwrRFAKIQIGLKVCDSA--DRIRDTLIHEMCH 596
Cdd:smart00731   1 QELTQRLED-ASLRVFGRKLPHP-KVVWNKRLRKTGGRCLL---------KSAEIRLNPKLLTENgrDRLRETLLHELCH 69
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445033    597 AASWLIDGIHdSHGDAWKYYARKSNRIHPElprvtRCHNYKINY--KVHYECTGCKTRIGCYTKSLDTSRFICAKCKGSL 674
Cdd:smart00731  70 AALYLFGRGY-GHGDEWKRWMRQVNGLFPE-----RCHTFLIESvkKYPYRCTGCGQRYLRVRRSNNVSRYRCGKCGGKL 143

                   ...
gi 16445033    675 VMV 677
Cdd:smart00731 144 ILI 146
PRK10819 super family cl35954
transport protein TonB; Provisional
380-478 5.60e-04

transport protein TonB; Provisional


The actual alignment was detected with superfamily member PRK10819:

Pssm-ID: 236768 [Multi-domain]  Cd Length: 246  Bit Score: 42.36  E-value: 5.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445033  380 SKPPSDPEANPEVSERKLPTEEEPAPVVEQSGKRKSKTKTI--VEPPRKRQTKTKNIVEPPRKRQTKTKNIVEPLRKRKA 457
Cdd:PRK10819  64 VQPPPEPVVEPEPEPEPIPEPPKEAPVVIPKPEPKPKPKPKpkPKPVKKVEEQPKREVKPVEPRPASPFENTAPARPTSS 143
                         90       100
                 ....*....|....*....|....*
gi 16445033  458 KTKNVSVTPGHK-KRGP---SKKKP 478
Cdd:PRK10819 144 TATAAASKPVTSvSSGPralSRNQP 168
 
Name Accession Description Interval E-value
SprT smart00731
SprT homologues; Predicted to have roles in transcription elongation. Contains a conserved ...
519-677 3.45e-43

SprT homologues; Predicted to have roles in transcription elongation. Contains a conserved HExxH motif, indicating a metalloprotease function.


Pssm-ID: 214794 [Multi-domain]  Cd Length: 146  Bit Score: 152.48  E-value: 3.45e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445033    519 DELVQRIYDlFNRSVCDKKLPEKlRIGWNNKMVKTAGLCSTgemwypkwrRFAKIQIGLKVCDSA--DRIRDTLIHEMCH 596
Cdd:smart00731   1 QELTQRLED-ASLRVFGRKLPHP-KVVWNKRLRKTGGRCLL---------KSAEIRLNPKLLTENgrDRLRETLLHELCH 69
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445033    597 AASWLIDGIHdSHGDAWKYYARKSNRIHPElprvtRCHNYKINY--KVHYECTGCKTRIGCYTKSLDTSRFICAKCKGSL 674
Cdd:smart00731  70 AALYLFGRGY-GHGDEWKRWMRQVNGLFPE-----RCHTFLIESvkKYPYRCTGCGQRYLRVRRSNNVSRYRCGKCGGKL 143

                   ...
gi 16445033    675 VMV 677
Cdd:smart00731 144 ILI 146
SprT-like pfam10263
SprT-like family; This family represents a domain found in eukaryotes and prokaryotes. The ...
522-634 1.55e-21

SprT-like family; This family represents a domain found in eukaryotes and prokaryotes. The domain contains a characteriztic motif of the zinc metallopeptidases. This family includes the bacterial SprT protein.


Pssm-ID: 463033  Cd Length: 106  Bit Score: 90.02  E-value: 1.55e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445033   522 VQRIYDLFNRSVCDKKLPEKLRIGWNNKMVKTAGLCStgemwypkWRRFAKIQIGLKVCD--SADRIRDTLIHEMCHAAS 599
Cdd:pfam10263   1 LEELFQQLNDEFFRGFLLPGVSVRWSKRLRTTAGRAH--------LKRKNEIRLSEPLLDenPEEFLRETLLHEMIHAYL 72
                          90       100       110
                  ....*....|....*....|....*....|....*
gi 16445033   600 WLIDGIHDSHGDAWKYYARKSNRIHPELPrVTRCH 634
Cdd:pfam10263  73 FVLFGRRRGHGPEFKAWMERINEAQTGLP-ITTYH 106
SprT COG3091
Predicted Zn-dependent metalloprotease, SprT family [General function prediction only];
517-675 7.92e-09

Predicted Zn-dependent metalloprotease, SprT family [General function prediction only];


Pssm-ID: 442325  Cd Length: 159  Bit Score: 55.28  E-value: 7.92e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445033 517 NKDELVQRIYDLFNRS--VCDKKLPEKlRIGWNNKmVKTAGLCstgemWYPKWR-RFAKIQIGLkvcDSADRIRDTLIHE 593
Cdd:COG3091   4 LQQELQRRVEQILQLAeeYFGRPFPHP-EVRFNLR-GTTAGRA-----HLQSHEiRLNPKLLEE---NGEEFLIEVVPHE 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445033 594 MCHAASWLIDGIHDSHGDAWKYYARKSNRIHPElprvtRCHNYKI----NYKVHYECtGCKTRigCYT-----KSLDTSR 664
Cdd:COG3091  74 LAHYHLYQEFGRVRPHGKEWRELMEKVGGLPPR-----RTHRFDVssvqGKRYLYRC-ACGQH--QLSrrrhnNVLRGAR 145
                       170
                ....*....|.
gi 16445033 665 FICAKCKGSLV 675
Cdd:COG3091 146 YRCRKCGGKLK 156
PRK10819 PRK10819
transport protein TonB; Provisional
380-478 5.60e-04

transport protein TonB; Provisional


Pssm-ID: 236768 [Multi-domain]  Cd Length: 246  Bit Score: 42.36  E-value: 5.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445033  380 SKPPSDPEANPEVSERKLPTEEEPAPVVEQSGKRKSKTKTI--VEPPRKRQTKTKNIVEPPRKRQTKTKNIVEPLRKRKA 457
Cdd:PRK10819  64 VQPPPEPVVEPEPEPEPIPEPPKEAPVVIPKPEPKPKPKPKpkPKPVKKVEEQPKREVKPVEPRPASPFENTAPARPTSS 143
                         90       100
                 ....*....|....*....|....*
gi 16445033  458 KTKNVSVTPGHK-KRGP---SKKKP 478
Cdd:PRK10819 144 TATAAASKPVTSvSSGPralSRNQP 168
 
Name Accession Description Interval E-value
SprT smart00731
SprT homologues; Predicted to have roles in transcription elongation. Contains a conserved ...
519-677 3.45e-43

SprT homologues; Predicted to have roles in transcription elongation. Contains a conserved HExxH motif, indicating a metalloprotease function.


Pssm-ID: 214794 [Multi-domain]  Cd Length: 146  Bit Score: 152.48  E-value: 3.45e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445033    519 DELVQRIYDlFNRSVCDKKLPEKlRIGWNNKMVKTAGLCSTgemwypkwrRFAKIQIGLKVCDSA--DRIRDTLIHEMCH 596
Cdd:smart00731   1 QELTQRLED-ASLRVFGRKLPHP-KVVWNKRLRKTGGRCLL---------KSAEIRLNPKLLTENgrDRLRETLLHELCH 69
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445033    597 AASWLIDGIHdSHGDAWKYYARKSNRIHPElprvtRCHNYKINY--KVHYECTGCKTRIGCYTKSLDTSRFICAKCKGSL 674
Cdd:smart00731  70 AALYLFGRGY-GHGDEWKRWMRQVNGLFPE-----RCHTFLIESvkKYPYRCTGCGQRYLRVRRSNNVSRYRCGKCGGKL 143

                   ...
gi 16445033    675 VMV 677
Cdd:smart00731 144 ILI 146
SprT-like pfam10263
SprT-like family; This family represents a domain found in eukaryotes and prokaryotes. The ...
522-634 1.55e-21

SprT-like family; This family represents a domain found in eukaryotes and prokaryotes. The domain contains a characteriztic motif of the zinc metallopeptidases. This family includes the bacterial SprT protein.


Pssm-ID: 463033  Cd Length: 106  Bit Score: 90.02  E-value: 1.55e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445033   522 VQRIYDLFNRSVCDKKLPEKLRIGWNNKMVKTAGLCStgemwypkWRRFAKIQIGLKVCD--SADRIRDTLIHEMCHAAS 599
Cdd:pfam10263   1 LEELFQQLNDEFFRGFLLPGVSVRWSKRLRTTAGRAH--------LKRKNEIRLSEPLLDenPEEFLRETLLHEMIHAYL 72
                          90       100       110
                  ....*....|....*....|....*....|....*
gi 16445033   600 WLIDGIHDSHGDAWKYYARKSNRIHPELPrVTRCH 634
Cdd:pfam10263  73 FVLFGRRRGHGPEFKAWMERINEAQTGLP-ITTYH 106
SprT COG3091
Predicted Zn-dependent metalloprotease, SprT family [General function prediction only];
517-675 7.92e-09

Predicted Zn-dependent metalloprotease, SprT family [General function prediction only];


Pssm-ID: 442325  Cd Length: 159  Bit Score: 55.28  E-value: 7.92e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445033 517 NKDELVQRIYDLFNRS--VCDKKLPEKlRIGWNNKmVKTAGLCstgemWYPKWR-RFAKIQIGLkvcDSADRIRDTLIHE 593
Cdd:COG3091   4 LQQELQRRVEQILQLAeeYFGRPFPHP-EVRFNLR-GTTAGRA-----HLQSHEiRLNPKLLEE---NGEEFLIEVVPHE 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445033 594 MCHAASWLIDGIHDSHGDAWKYYARKSNRIHPElprvtRCHNYKI----NYKVHYECtGCKTRigCYT-----KSLDTSR 664
Cdd:COG3091  74 LAHYHLYQEFGRVRPHGKEWRELMEKVGGLPPR-----RTHRFDVssvqGKRYLYRC-ACGQH--QLSrrrhnNVLRGAR 145
                       170
                ....*....|.
gi 16445033 665 FICAKCKGSLV 675
Cdd:COG3091 146 YRCRKCGGKLK 156
PRK10819 PRK10819
transport protein TonB; Provisional
380-478 5.60e-04

transport protein TonB; Provisional


Pssm-ID: 236768 [Multi-domain]  Cd Length: 246  Bit Score: 42.36  E-value: 5.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445033  380 SKPPSDPEANPEVSERKLPTEEEPAPVVEQSGKRKSKTKTI--VEPPRKRQTKTKNIVEPPRKRQTKTKNIVEPLRKRKA 457
Cdd:PRK10819  64 VQPPPEPVVEPEPEPEPIPEPPKEAPVVIPKPEPKPKPKPKpkPKPVKKVEEQPKREVKPVEPRPASPFENTAPARPTSS 143
                         90       100
                 ....*....|....*....|....*
gi 16445033  458 KTKNVSVTPGHK-KRGP---SKKKP 478
Cdd:PRK10819 144 TATAAASKPVTSvSSGPralSRNQP 168
Zn_ribbon_SprT pfam17283
SprT-like zinc ribbon domain; This family represents a domain found in eukaryotes and ...
640-676 4.31e-03

SprT-like zinc ribbon domain; This family represents a domain found in eukaryotes and prokaryotes. The domain contains a characteriztic motif of the zinc ribbon. This family includes the bacterial SprT protein.


Pssm-ID: 465398  Cd Length: 38  Bit Score: 35.36  E-value: 4.31e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 16445033   640 YKVHYECTGCKTRIGcYTKSLDTSRFICAKCKGSLVM 676
Cdd:pfam17283   1 YKYVYRCPSCGREYP-RHRRSDRHNYRCRRCKGTLGQ 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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