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Conserved domains on  [gi|47132547|ref|NP_473375|]
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fibronectin isoform 7 preproprotein [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 353-401 6.93e-21

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


:

Pssm-ID: 128373  Cd Length: 49  Bit Score: 86.20  E-value: 6.93e-21
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 47132547    353 GNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFC 401
Cdd:smart00059   1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 413-461 2.93e-20

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


:

Pssm-ID: 128373  Cd Length: 49  Bit Score: 84.27  E-value: 2.93e-20
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 47132547    413 GNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFC 461
Cdd:smart00059   1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 186-230 1.93e-12

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 61.98  E-value: 1.93e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 47132547    186 CFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNR 230
Cdd:smart00058   1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 561-604 3.86e-12

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 61.21  E-value: 3.86e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 47132547    561 CQDSETGTFYQIGDSWEK-YVHGVRYQCYCYGRGIGEWHCQPLQT 604
Cdd:smart00058   1 CFDEETGTTYRVGDTWERpYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 231-275 1.01e-11

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 60.06  E-value: 1.01e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 47132547    231 CNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTS 275
Cdd:smart00058   1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 470-508 1.39e-11

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 59.67  E-value: 1.39e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 47132547    470 CTTNE-GVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTC 508
Cdd:smart00058   1 CFDEEtGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKC 40
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 523-560 6.50e-11

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 57.75  E-value: 6.50e-11
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 47132547    523 ITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPVDQ 560
Cdd:smart00058   8 TTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 97-140 1.26e-09

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 53.89  E-value: 1.26e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 47132547     97 CFDKYTGNTYRVGDTYERPKDS-MIWDCTCIGAGRGRISCTIANR 140
Cdd:smart00058   1 CFDEETGTTYRVGDTWERPYEGgHVLQCTCLGGGRGEWKCDPVPV 45
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 142-184 3.10e-09

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 52.74  E-value: 3.10e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 47132547    142 HEGGQSYKIGDTWRRPHEtGGYMLECVCLGNGKGEWTCKPIAE 184
Cdd:smart00058   4 EETGTTYRVGDTWERPYE-GGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 52-89 3.64e-08

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


:

Pssm-ID: 238018  Cd Length: 43  Bit Score: 49.64  E-value: 3.64e-08
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 47132547  52 CYDN--GKHYQINQQWERTYLGNALVCTCYGGSRGFNCES 89
Cdd:cd00061   3 CFDPqtGVFYRVGETWERPSEGHVLQCTCLGNRGEARCDP 42
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 307-345 8.22e-04

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


:

Pssm-ID: 238018  Cd Length: 43  Bit Score: 37.31  E-value: 8.22e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 47132547 307 HCVTDS-GVVYSVGMQWLKTQGNKQMLCTCLGN--GVSCQET 345
Cdd:cd00061   2 KCFDPQtGVFYRVGETWERPSEGHVLQCTCLGNrgEARCDPV 43
 
Name Accession Description Interval E-value
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 353-401 6.93e-21

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


Pssm-ID: 128373  Cd Length: 49  Bit Score: 86.20  E-value: 6.93e-21
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 47132547    353 GNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFC 401
Cdd:smart00059   1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 413-461 2.93e-20

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


Pssm-ID: 128373  Cd Length: 49  Bit Score: 84.27  E-value: 2.93e-20
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 47132547    413 GNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFC 461
Cdd:smart00059   1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
FN2 cd00062
Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to ...
 354-401 1.61e-19

Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. Fibronectin is composed of 3 types of modules, FN1,FN2 and FN3. The collagen binding domain contains four FN1 and two FN2 repeats.


Pssm-ID: 238019  Cd Length: 48  Bit Score: 81.97  E-value: 1.61e-19
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 47132547 354 NSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFC 401
Cdd:cd00062   1 NSDGAPCVFPFIYRGKWYHDCTTEGSNDGKLWCSTTPNYDRDGKWGYC 48
FN2 cd00062
Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to ...
 414-461 1.83e-19

Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. Fibronectin is composed of 3 types of modules, FN1,FN2 and FN3. The collagen binding domain contains four FN1 and two FN2 repeats.


Pssm-ID: 238019  Cd Length: 48  Bit Score: 81.97  E-value: 1.83e-19
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 47132547 414 NSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFC 461
Cdd:cd00062   1 NSDGAPCVFPFIYRGKWYHDCTTEGSNDGKLWCSTTPNYDRDGKWGYC 48
fn2 pfam00040
Fibronectin type II domain;
360-401 1.97e-17

Fibronectin type II domain;


Pssm-ID: 459645  Cd Length: 42  Bit Score: 76.07  E-value: 1.97e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 47132547   360 CVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFC 401
Cdd:pfam00040   1 CVFPFKYKGKWYHTCTTDGRRSGRLWCATTANYDGDGKWGYC 42
fn2 pfam00040
Fibronectin type II domain;
420-461 8.99e-16

Fibronectin type II domain;


Pssm-ID: 459645  Cd Length: 42  Bit Score: 71.45  E-value: 8.99e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 47132547   420 CHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFC 461
Cdd:pfam00040   1 CVFPFKYKGKWYHTCTTDGRRSGRLWCATTANYDGDGKWGYC 42
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 186-230 1.93e-12

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 61.98  E-value: 1.93e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 47132547    186 CFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNR 230
Cdd:smart00058   1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 561-604 3.86e-12

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 61.21  E-value: 3.86e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 47132547    561 CQDSETGTFYQIGDSWEK-YVHGVRYQCYCYGRGIGEWHCQPLQT 604
Cdd:smart00058   1 CFDEETGTTYRVGDTWERpYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 231-275 1.01e-11

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 60.06  E-value: 1.01e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 47132547    231 CNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTS 275
Cdd:smart00058   1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 470-508 1.39e-11

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 59.67  E-value: 1.39e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 47132547    470 CTTNE-GVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTC 508
Cdd:smart00058   1 CFDEEtGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKC 40
fn1 pfam00039
Fibronectin type I domain;
231-270 1.52e-11

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 59.25  E-value: 1.52e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 47132547   231 CNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKC 270
Cdd:pfam00039   1 CYDPQTGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 523-560 6.50e-11

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 57.75  E-value: 6.50e-11
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 47132547    523 ITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPVDQ 560
Cdd:smart00058   8 TTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
fn1 pfam00039
Fibronectin type I domain;
470-508 1.86e-10

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 56.17  E-value: 1.86e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 47132547   470 CTTNE-GVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTC 508
Cdd:pfam00039   1 CYDPQtGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
fn1 pfam00039
Fibronectin type I domain;
561-599 3.15e-10

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 55.40  E-value: 3.15e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 47132547   561 CQDSETGTFYQIGDSWEK-YVHGVRYQCYCYGRGIGEWHC 599
Cdd:pfam00039   1 CYDPQTGRFYQVGETWERpSQRGHVLQCTCLGNGGGEIRC 40
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 559-602 3.84e-10

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 55.42  E-value: 3.84e-10
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 47132547 559 DQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGrGIGEWHCQPL 602
Cdd:cd00061   1 EKCFDPQTGVFYRVGETWERPSEGHVLQCTCLG-NRGEARCDPV 43
fn1 pfam00039
Fibronectin type I domain;
186-225 5.24e-10

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 55.01  E-value: 5.24e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 47132547   186 CFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITC 225
Cdd:pfam00039   1 CYDPQTGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 97-140 1.26e-09

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 53.89  E-value: 1.26e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 47132547     97 CFDKYTGNTYRVGDTYERPKDS-MIWDCTCIGAGRGRISCTIANR 140
Cdd:smart00058   1 CFDEETGTTYRVGDTWERPYEGgHVLQCTCLGGGRGEWKCDPVPV 45
fn1 pfam00039
Fibronectin type I domain;
97-135 2.85e-09

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 52.70  E-value: 2.85e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 47132547    97 CFDKYTGNTYRVGDTYERPKDS-MIWDCTCIGAGRGRISC 135
Cdd:pfam00039   1 CYDPQTGRFYQVGETWERPSQRgHVLQCTCLGNGGGEIRC 40
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 142-184 3.10e-09

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 52.74  E-value: 3.10e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 47132547    142 HEGGQSYKIGDTWRRPHEtGGYMLECVCLGNGKGEWTCKPIAE 184
Cdd:smart00058   4 EETGTTYRVGDTWERPYE-GGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 95-136 5.04e-09

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 52.33  E-value: 5.04e-09
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 47132547  95 ETCFDKYTGNTYRVGDTYERPKDSMIWDCTCIGaGRGRISCT 136
Cdd:cd00061   1 EKCFDPQTGVFYRVGETWERPSEGHVLQCTCLG-NRGEARCD 41
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 184-227 3.61e-08

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 49.64  E-value: 3.61e-08
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 47132547 184 EKCFDHAAGTSYVVGETWEKPYQGwMMVDCTCLGeGSGRITCTS 227
Cdd:cd00061   1 EKCFDPQTGVFYRVGETWERPSEG-HVLQCTCLG-NRGEARCDP 42
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 52-89 3.64e-08

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 49.64  E-value: 3.64e-08
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 47132547  52 CYDN--GKHYQINQQWERTYLGNALVCTCYGGSRGFNCES 89
Cdd:cd00061   3 CFDPqtGVFYRVGETWERPSEGHVLQCTCLGNRGEARCDP 42
fn1 pfam00039
Fibronectin type I domain;
143-179 8.93e-08

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 48.46  E-value: 8.93e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 47132547   143 EGGQSYKIGDTWRRPHETGgYMLECVCLGNGKGEWTC 179
Cdd:pfam00039   5 QTGRFYQVGETWERPSQRG-HVLQCTCLGNGGGEIRC 40
fn1 pfam00039
Fibronectin type I domain;
524-555 9.75e-08

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 48.46  E-value: 9.75e-08
                          10        20        30
                  ....*....|....*....|....*....|..
gi 47132547   524 TYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKC 555
Cdd:pfam00039   9 FYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 468-508 2.69e-07

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 47.33  E-value: 2.69e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 47132547 468 EICTTNE-GVMYRIGDQWDKQHDmGHMMRCTCVGNgRGEWTC 508
Cdd:cd00061   1 EKCFDPQtGVFYRVGETWERPSE-GHVLQCTCLGN-RGEARC 40
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 229-273 5.89e-07

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 46.17  E-value: 5.89e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 47132547 229 NRCNDQDTRTSYRIGDTWSKKDNrGNLLQCICTGNgRGEWKCERH 273
Cdd:cd00061   1 EKCFDPQTGVFYRVGETWERPSE-GHVLQCTCLGN-RGEARCDPV 43
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 52-92 2.40e-06

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 44.65  E-value: 2.40e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 47132547     52 CYDN--GKHYQINQQWERTYL-GNALVCTCYGGSRG-FNCESKPE 92
Cdd:smart00058   1 CFDEetGTTYRVGDTWERPYEgGHVLQCTCLGGGRGeWKCDPVPV 45
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 139-181 6.84e-06

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 43.47  E-value: 6.84e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 47132547 139 NRCHEG--GQSYKIGDTWRRPHEtgGYMLECVCLGNgKGEWTCKP 181
Cdd:cd00061   1 EKCFDPqtGVFYRVGETWERPSE--GHVLQCTCLGN-RGEARCDP 42
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 516-558 7.85e-06

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 43.09  E-value: 7.85e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 47132547 516 DQCIVDD--ITYNVNDTFHKRHEeGHMLNCTCFGqGRGRWKCDPV 558
Cdd:cd00061   1 EKCFDPQtgVFYRVGETWERPSE-GHVLQCTCLG-NRGEARCDPV 43
fn1 pfam00039
Fibronectin type I domain;
52-87 7.94e-05

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 40.37  E-value: 7.94e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 47132547    52 CYDN--GKHYQINQQWERTYL-GNALVCTCYGGSRG-FNC 87
Cdd:pfam00039   1 CYDPqtGRFYQVGETWERPSQrGHVLQCTCLGNGGGeIRC 40
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 307-345 8.22e-04

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 37.31  E-value: 8.22e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 47132547 307 HCVTDS-GVVYSVGMQWLKTQGNKQMLCTCLGN--GVSCQET 345
Cdd:cd00061   2 KCFDPQtGVFYRVGETWERPSEGHVLQCTCLGNrgEARCDPV 43
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 311-347 1.45e-03

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 36.95  E-value: 1.45e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 47132547    311 DSGVVYSVGMQWLKTQGNKQML-CTCLGNG---VSCQETAV 347
Cdd:smart00058   5 ETGTTYRVGDTWERPYEGGHVLqCTCLGGGrgeWKCDPVPV 45
 
Name Accession Description Interval E-value
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 353-401 6.93e-21

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


Pssm-ID: 128373  Cd Length: 49  Bit Score: 86.20  E-value: 6.93e-21
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 47132547    353 GNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFC 401
Cdd:smart00059   1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 413-461 2.93e-20

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


Pssm-ID: 128373  Cd Length: 49  Bit Score: 84.27  E-value: 2.93e-20
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 47132547    413 GNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFC 461
Cdd:smart00059   1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
FN2 cd00062
Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to ...
 354-401 1.61e-19

Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. Fibronectin is composed of 3 types of modules, FN1,FN2 and FN3. The collagen binding domain contains four FN1 and two FN2 repeats.


Pssm-ID: 238019  Cd Length: 48  Bit Score: 81.97  E-value: 1.61e-19
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 47132547 354 NSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFC 401
Cdd:cd00062   1 NSDGAPCVFPFIYRGKWYHDCTTEGSNDGKLWCSTTPNYDRDGKWGYC 48
FN2 cd00062
Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to ...
 414-461 1.83e-19

Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. Fibronectin is composed of 3 types of modules, FN1,FN2 and FN3. The collagen binding domain contains four FN1 and two FN2 repeats.


Pssm-ID: 238019  Cd Length: 48  Bit Score: 81.97  E-value: 1.83e-19
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 47132547 414 NSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFC 461
Cdd:cd00062   1 NSDGAPCVFPFIYRGKWYHDCTTEGSNDGKLWCSTTPNYDRDGKWGYC 48
fn2 pfam00040
Fibronectin type II domain;
360-401 1.97e-17

Fibronectin type II domain;


Pssm-ID: 459645  Cd Length: 42  Bit Score: 76.07  E-value: 1.97e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 47132547   360 CVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFC 401
Cdd:pfam00040   1 CVFPFKYKGKWYHTCTTDGRRSGRLWCATTANYDGDGKWGYC 42
fn2 pfam00040
Fibronectin type II domain;
420-461 8.99e-16

Fibronectin type II domain;


Pssm-ID: 459645  Cd Length: 42  Bit Score: 71.45  E-value: 8.99e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 47132547   420 CHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFC 461
Cdd:pfam00040   1 CVFPFKYKGKWYHTCTTDGRRSGRLWCATTANYDGDGKWGYC 42
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 186-230 1.93e-12

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 61.98  E-value: 1.93e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 47132547    186 CFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNR 230
Cdd:smart00058   1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 561-604 3.86e-12

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 61.21  E-value: 3.86e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 47132547    561 CQDSETGTFYQIGDSWEK-YVHGVRYQCYCYGRGIGEWHCQPLQT 604
Cdd:smart00058   1 CFDEETGTTYRVGDTWERpYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 231-275 1.01e-11

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 60.06  E-value: 1.01e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 47132547    231 CNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTS 275
Cdd:smart00058   1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 470-508 1.39e-11

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 59.67  E-value: 1.39e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 47132547    470 CTTNE-GVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTC 508
Cdd:smart00058   1 CFDEEtGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKC 40
fn1 pfam00039
Fibronectin type I domain;
231-270 1.52e-11

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 59.25  E-value: 1.52e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 47132547   231 CNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKC 270
Cdd:pfam00039   1 CYDPQTGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 523-560 6.50e-11

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 57.75  E-value: 6.50e-11
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 47132547    523 ITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPVDQ 560
Cdd:smart00058   8 TTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
fn1 pfam00039
Fibronectin type I domain;
470-508 1.86e-10

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 56.17  E-value: 1.86e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 47132547   470 CTTNE-GVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTC 508
Cdd:pfam00039   1 CYDPQtGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
fn1 pfam00039
Fibronectin type I domain;
561-599 3.15e-10

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 55.40  E-value: 3.15e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 47132547   561 CQDSETGTFYQIGDSWEK-YVHGVRYQCYCYGRGIGEWHC 599
Cdd:pfam00039   1 CYDPQTGRFYQVGETWERpSQRGHVLQCTCLGNGGGEIRC 40
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 559-602 3.84e-10

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 55.42  E-value: 3.84e-10
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 47132547 559 DQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGrGIGEWHCQPL 602
Cdd:cd00061   1 EKCFDPQTGVFYRVGETWERPSEGHVLQCTCLG-NRGEARCDPV 43
fn1 pfam00039
Fibronectin type I domain;
186-225 5.24e-10

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 55.01  E-value: 5.24e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 47132547   186 CFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITC 225
Cdd:pfam00039   1 CYDPQTGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 97-140 1.26e-09

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 53.89  E-value: 1.26e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 47132547     97 CFDKYTGNTYRVGDTYERPKDS-MIWDCTCIGAGRGRISCTIANR 140
Cdd:smart00058   1 CFDEETGTTYRVGDTWERPYEGgHVLQCTCLGGGRGEWKCDPVPV 45
fn1 pfam00039
Fibronectin type I domain;
97-135 2.85e-09

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 52.70  E-value: 2.85e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 47132547    97 CFDKYTGNTYRVGDTYERPKDS-MIWDCTCIGAGRGRISC 135
Cdd:pfam00039   1 CYDPQTGRFYQVGETWERPSQRgHVLQCTCLGNGGGEIRC 40
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 142-184 3.10e-09

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 52.74  E-value: 3.10e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 47132547    142 HEGGQSYKIGDTWRRPHEtGGYMLECVCLGNGKGEWTCKPIAE 184
Cdd:smart00058   4 EETGTTYRVGDTWERPYE-GGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 95-136 5.04e-09

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 52.33  E-value: 5.04e-09
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 47132547  95 ETCFDKYTGNTYRVGDTYERPKDSMIWDCTCIGaGRGRISCT 136
Cdd:cd00061   1 EKCFDPQTGVFYRVGETWERPSEGHVLQCTCLG-NRGEARCD 41
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 184-227 3.61e-08

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 49.64  E-value: 3.61e-08
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 47132547 184 EKCFDHAAGTSYVVGETWEKPYQGwMMVDCTCLGeGSGRITCTS 227
Cdd:cd00061   1 EKCFDPQTGVFYRVGETWERPSEG-HVLQCTCLG-NRGEARCDP 42
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 52-89 3.64e-08

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 49.64  E-value: 3.64e-08
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 47132547  52 CYDN--GKHYQINQQWERTYLGNALVCTCYGGSRGFNCES 89
Cdd:cd00061   3 CFDPqtGVFYRVGETWERPSEGHVLQCTCLGNRGEARCDP 42
fn1 pfam00039
Fibronectin type I domain;
143-179 8.93e-08

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 48.46  E-value: 8.93e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 47132547   143 EGGQSYKIGDTWRRPHETGgYMLECVCLGNGKGEWTC 179
Cdd:pfam00039   5 QTGRFYQVGETWERPSQRG-HVLQCTCLGNGGGEIRC 40
fn1 pfam00039
Fibronectin type I domain;
524-555 9.75e-08

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 48.46  E-value: 9.75e-08
                          10        20        30
                  ....*....|....*....|....*....|..
gi 47132547   524 TYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKC 555
Cdd:pfam00039   9 FYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 468-508 2.69e-07

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 47.33  E-value: 2.69e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 47132547 468 EICTTNE-GVMYRIGDQWDKQHDmGHMMRCTCVGNgRGEWTC 508
Cdd:cd00061   1 EKCFDPQtGVFYRVGETWERPSE-GHVLQCTCLGN-RGEARC 40
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 229-273 5.89e-07

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 46.17  E-value: 5.89e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 47132547 229 NRCNDQDTRTSYRIGDTWSKKDNrGNLLQCICTGNgRGEWKCERH 273
Cdd:cd00061   1 EKCFDPQTGVFYRVGETWERPSE-GHVLQCTCLGN-RGEARCDPV 43
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 52-92 2.40e-06

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 44.65  E-value: 2.40e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 47132547     52 CYDN--GKHYQINQQWERTYL-GNALVCTCYGGSRG-FNCESKPE 92
Cdd:smart00058   1 CFDEetGTTYRVGDTWERPYEgGHVLQCTCLGGGRGeWKCDPVPV 45
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 139-181 6.84e-06

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 43.47  E-value: 6.84e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 47132547 139 NRCHEG--GQSYKIGDTWRRPHEtgGYMLECVCLGNgKGEWTCKP 181
Cdd:cd00061   1 EKCFDPqtGVFYRVGETWERPSE--GHVLQCTCLGN-RGEARCDP 42
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 516-558 7.85e-06

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 43.09  E-value: 7.85e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 47132547 516 DQCIVDD--ITYNVNDTFHKRHEeGHMLNCTCFGqGRGRWKCDPV 558
Cdd:cd00061   1 EKCFDPQtgVFYRVGETWERPSE-GHVLQCTCLG-NRGEARCDPV 43
fn1 pfam00039
Fibronectin type I domain;
52-87 7.94e-05

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 40.37  E-value: 7.94e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 47132547    52 CYDN--GKHYQINQQWERTYL-GNALVCTCYGGSRG-FNC 87
Cdd:pfam00039   1 CYDPqtGRFYQVGETWERPSQrGHVLQCTCLGNGGGeIRC 40
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 307-345 8.22e-04

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 37.31  E-value: 8.22e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 47132547 307 HCVTDS-GVVYSVGMQWLKTQGNKQMLCTCLGN--GVSCQET 345
Cdd:cd00061   2 KCFDPQtGVFYRVGETWERPSEGHVLQCTCLGNrgEARCDPV 43
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 311-347 1.45e-03

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 36.95  E-value: 1.45e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 47132547    311 DSGVVYSVGMQWLKTQGNKQML-CTCLGNG---VSCQETAV 347
Cdd:smart00058   5 ETGTTYRVGDTWERPYEGGHVLqCTCLGGGrgeWKCDPVPV 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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