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Conserved domains on  [gi|17507681|ref|NP_490688|]
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Carboxylic ester hydrolase [Caenorhabditis elegans]

Protein Classification

carboxylesterase/lipase family protein( domain architecture ID 10444481)

carboxylesterase/lipase family protein similar to carboxylesterase, which catalyzes the hydrolysis of a carboxylic ester to form an alcohol and a carboxylate

CATH:  3.40.50.1820
EC:  3.1.1.-
Gene Ontology:  GO:0052689
PubMed:  8453375|3163407|8280778|9704093|11099800|37582413|31545554
SCOP:  3000102|4000699

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COesterase pfam00135
Carboxylesterase family;
16-535 1.49e-172

Carboxylesterase family;


:

Pssm-ID: 395084 [Multi-domain]  Cd Length: 513  Bit Score: 497.60  E-value: 1.49e-172
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507681    16 DATCGPIKGVGYEQEDGSVVEGFLGIPYAEPPIGALRFKKPVAHRKWTEPLDCVRFGPRSPQNDELLGQFVNTVGKSEEh 95
Cdd:pfam00135   6 TTSLGRVRGKRLKVDGGKPVYAFLGIPYAEPPVGELRFQPPEPPEPWTGVRDATKFGPRCPQNGDLTSPGSSGLEGSED- 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507681    96 CLSLNVFTPKWESNEwPDGFPVMVFIHGGGFAVHSSSNYGCASIARNLctkDVVVVTINYRLGVLGFFTTGDEVCRGNLG 175
Cdd:pfam00135  85 CLYLNVYTPKELKEN-KNKLPVMVWIHGGGFMFGSGSLYDGSYLAAEG---DVIVVTINYRLGPLGFLSTGDDEAPGNYG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507681   176 LWDQTAALEWVQENIQSFRGDPDNVTIFGQSAGGASVDLLCLSPHSRGLFNRAIPMAGNGECDFAMRTSEQQAqlSREFA 255
Cdd:pfam00135 161 LLDQVLALRWVQENIASFGGDPNRVTLFGESAGAASVSLLLLSPLSKGLFHRAILMSGSALSPWAIQSNARQR--AKELA 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507681   256 RYLGWEGddNDSEDLLQFIDQQPLYKIEMgINPKRGFKHSqAGSLYFVPNFDGDFFPK-PLNQLRKE-APKMQIMTGTTK 333
Cdd:pfam00135 239 KLVGCPT--SDSAELVECLRSKPAEELLD-AQLKLLVYGS-VPFVPFGPVVDGDFLPEhPEELLKSGnFPKVPLLIGVTK 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507681   334 YEGLFFIALGALSKNPEGIK--KFMGRIFKECDYGERA---DDVLQMVYDFYFKGVHPKDHEKNMHQIVKFIGDYSINYG 408
Cdd:pfam00135 315 DEGLLFAAYILDNVDILKALeeKLLRSLLIDLLYLLLVdlpEEISAALREEYLDWGDRDDPETSRRALVELLTDYLFNCP 394

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507681   409 TYRLANIMTDLQHDVYFYQFDYHNSAGfgvfrWLLPFLGSTHCTEMRYVLGKGIISKFRPNDNDKKMLHVMTTYFTNFAK 488
Cdd:pfam00135 395 VIRFADLHASRGTPVYMYSFDYRGSSL-----RYPKWVGVDHGDELPYVFGTPFVGALLFTEEDEKLSRKMMTYWTNFAK 469

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*..
gi 17507681   489 YGNPNGENQETgEWQKHDSAHPfRHFKIDLdDSEMVEDYQERRAELW 535
Cdd:pfam00135 470 TGNPNGPEGLP-KWPPYTDENG-QYLSIDL-EPRVKQGLKAERCAFW 513
 
Name Accession Description Interval E-value
COesterase pfam00135
Carboxylesterase family;
16-535 1.49e-172

Carboxylesterase family;


Pssm-ID: 395084 [Multi-domain]  Cd Length: 513  Bit Score: 497.60  E-value: 1.49e-172
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507681    16 DATCGPIKGVGYEQEDGSVVEGFLGIPYAEPPIGALRFKKPVAHRKWTEPLDCVRFGPRSPQNDELLGQFVNTVGKSEEh 95
Cdd:pfam00135   6 TTSLGRVRGKRLKVDGGKPVYAFLGIPYAEPPVGELRFQPPEPPEPWTGVRDATKFGPRCPQNGDLTSPGSSGLEGSED- 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507681    96 CLSLNVFTPKWESNEwPDGFPVMVFIHGGGFAVHSSSNYGCASIARNLctkDVVVVTINYRLGVLGFFTTGDEVCRGNLG 175
Cdd:pfam00135  85 CLYLNVYTPKELKEN-KNKLPVMVWIHGGGFMFGSGSLYDGSYLAAEG---DVIVVTINYRLGPLGFLSTGDDEAPGNYG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507681   176 LWDQTAALEWVQENIQSFRGDPDNVTIFGQSAGGASVDLLCLSPHSRGLFNRAIPMAGNGECDFAMRTSEQQAqlSREFA 255
Cdd:pfam00135 161 LLDQVLALRWVQENIASFGGDPNRVTLFGESAGAASVSLLLLSPLSKGLFHRAILMSGSALSPWAIQSNARQR--AKELA 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507681   256 RYLGWEGddNDSEDLLQFIDQQPLYKIEMgINPKRGFKHSqAGSLYFVPNFDGDFFPK-PLNQLRKE-APKMQIMTGTTK 333
Cdd:pfam00135 239 KLVGCPT--SDSAELVECLRSKPAEELLD-AQLKLLVYGS-VPFVPFGPVVDGDFLPEhPEELLKSGnFPKVPLLIGVTK 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507681   334 YEGLFFIALGALSKNPEGIK--KFMGRIFKECDYGERA---DDVLQMVYDFYFKGVHPKDHEKNMHQIVKFIGDYSINYG 408
Cdd:pfam00135 315 DEGLLFAAYILDNVDILKALeeKLLRSLLIDLLYLLLVdlpEEISAALREEYLDWGDRDDPETSRRALVELLTDYLFNCP 394

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507681   409 TYRLANIMTDLQHDVYFYQFDYHNSAGfgvfrWLLPFLGSTHCTEMRYVLGKGIISKFRPNDNDKKMLHVMTTYFTNFAK 488
Cdd:pfam00135 395 VIRFADLHASRGTPVYMYSFDYRGSSL-----RYPKWVGVDHGDELPYVFGTPFVGALLFTEEDEKLSRKMMTYWTNFAK 469

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*..
gi 17507681   489 YGNPNGENQETgEWQKHDSAHPfRHFKIDLdDSEMVEDYQERRAELW 535
Cdd:pfam00135 470 TGNPNGPEGLP-KWPPYTDENG-QYLSIDL-EPRVKQGLKAERCAFW 513
Esterase_lipase cd00312
Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on ...
 16-508 2.46e-142

Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These catalytic residues are responsible for the nucleophilic attack on the carbonyl carbon atom of the ester bond. In contrast with other alpha/beta hydrolase fold family members, p-nitrobenzyl esterase and acetylcholine esterase have a Glu instead of Asp at the active site carboxylate.


Pssm-ID: 238191 [Multi-domain]  Cd Length: 493  Bit Score: 419.81  E-value: 2.46e-142
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507681  16 DATCGPIKGVgyeQEDGsvVEGFLGIPYAEPPIGALRFKKPVAHRKWTEPLDCVRFGPRSPQNDELLGQFVNTVGKSEEH 95
Cdd:cd00312   3 VTPNGKVRGV---DEGG--VYSFLGIPYAEPPVGDLRFKEPQPYEPWSDVLDATSYPPSCMQWDQLGGGLWNAKLPGSED 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507681  96 CLSLNVFTPKweSNEWPDGFPVMVFIHGGGFAVHSSSNYGCASIARNLctKDVVVVTINYRLGVLGFFTTGDEVCRGNLG 175
Cdd:cd00312  78 CLYLNVYTPK--NTKPGNSLPVMVWIHGGGFMFGSGSLYPGDGLAREG--DNVIVVSINYRLGVLGFLSTGDIELPGNYG 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507681 176 LWDQTAALEWVQENIQSFRGDPDNVTIFGQSAGGASVDLLCLSPHSRGLFNRAIPMAGNGECDFAmrTSEQQAQLSREFA 255
Cdd:cd00312 154 LKDQRLALKWVQDNIAAFGGDPDSVTIFGESAGGASVSLLLLSPDSKGLFHRAISQSGSALSPWA--IQENARGRAKRLA 231

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507681 256 RYLGWegDDNDSEDLLQFIDQQPLYKIemgINPKRGFK-HSQAGSLYFVPNFDGDFFPKPLNQLRKE--APKMQIMTGTT 332
Cdd:cd00312 232 RLLGC--NDTSSAELLDCLRSKSAEEL---LDATRKLLlFSYSPFLPFGPVVDGDFIPDDPEELIKEgkFAKVPLIIGVT 306

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507681 333 KYEGLFFIALGaLSKNPEGIKKFMGRIFKECDYGE--RADDVLQMVYDFYFKGVhpKDHEKNMHQIVKFIGDYSINYGT- 409
Cdd:cd00312 307 KDEGGYFAAML-LNFDAKLIIETNDRWLELLPYLLfyADDALADKVLEKYPGDV--DDSVESRKNLSDMLTDLLFKCPAr 383

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507681 410 YRLANIMTDLQHDVYFYQFDYHNSagFGVFRWlLPFLGSTHCTEMRYVLGKGIISKFRPNDnDKKMLHVMTTYFTNFAKY 489
Cdd:cd00312 384 YFLAQHRKAGGSPVYAYVFDHRSS--LSVGRW-PPWLGTVHGDEIFFVFGNPLLKEGLREE-EEKLSRTMMKYWANFAKT 459

                       490
                ....*....|....*....
gi 17507681 490 GNPNGENQETgEWQKHDSA 508
Cdd:cd00312 460 GNPNTEGNLV-VWPAYTSE 477
PnbA COG2272
Carboxylesterase type B [Lipid transport and metabolism];
18-539 1.56e-135

Carboxylesterase type B [Lipid transport and metabolism];


Pssm-ID: 441873  Cd Length: 500  Bit Score: 402.73  E-value: 1.56e-135
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507681  18 TCGPIKGVgyeQEDGSVVegFLGIPYAEPPIGALRFKKPVAHRKWTEPLDCVRFGPRSPQNDELlGQFVNTVGKSEEhCL 97
Cdd:COG2272  18 EAGRVRGV---VEGGVRV--FLGIPYAAPPVGELRWRAPQPVEPWTGVRDATEFGPACPQPPRP-GDPGGPAPGSED-CL 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507681  98 SLNVFTPKWESNEwpdGFPVMVFIHGGGFAVHSSS--NYGCASIARnlctKDVVVVTINYRLGVLGFF-----TTGDEVC 170
Cdd:COG2272  91 YLNVWTPALAAGA---KLPVMVWIHGGGFVSGSGSepLYDGAALAR----RGVVVVTINYRLGALGFLalpalSGESYGA 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507681 171 RGNLGLWDQTAALEWVQENIQSFRGDPDNVTIFGQSAGGASVDLLCLSPHSRGLFNRAIPMAGNGecdFAMRTSEQQAQL 250
Cdd:COG2272 164 SGNYGLLDQIAALRWVRDNIAAFGGDPDNVTIFGESAGAASVAALLASPLAKGLFHRAIAQSGAG---LSVLTLAEAEAV 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507681 251 SREFARYLGWEgdDNDSEDLLQfIDQQPLYKIEMGINPKRGfkhsqaGSLYFVPNFDGDFFPK-PLNQLRK-EAPKMQIM 328
Cdd:COG2272 241 GAAFAAALGVA--PATLAALRA-LPAEELLAAQAALAAEGP------GGLPFGPVVDGDVLPEdPLEAFAAgRAADVPLL 311

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507681 329 TGTTKYEGLFFIALGALSK--NPEGIKKFMGRIFkecdyGERADDVLQmVYDfyfkGVHPKDheknmhQIVKFIGDYSIN 406
Cdd:COG2272 312 IGTNRDEGRLFAALLGDLGplTAADYRAALRRRF-----GDDADEVLA-AYP----AASPAE------ALAALATDRVFR 375

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507681 407 YGTYRLANIMTDLQHDVYFYQFDYHnSAGFGVFRwllpfLGSTHCTEMRYVLGKGIISKFRPNDN-DKKMLHVMTTYFTN 485
Cdd:COG2272 376 CPARRLAEAHAAAGAPVYLYRFDWR-SPPLRGFG-----LGAFHGAELPFVFGNLDAPALTGLTPaDRALSDQMQAYWVN 449

                       490       500       510       520       530
                ....*....|....*....|....*....|....*....|....*....|....
gi 17507681 486 FAKYGNPNGENQetGEWQKHDSAHPfRHFKIDLDDSEMVEDYQERRAELWDKLR 539
Cdd:COG2272 450 FARTGDPNGPGL--PEWPAYDPEDR-AVMVFDAEPRVVNDPDAEERLDLWDGVV 500
 
Name Accession Description Interval E-value
COesterase pfam00135
Carboxylesterase family;
16-535 1.49e-172

Carboxylesterase family;


Pssm-ID: 395084 [Multi-domain]  Cd Length: 513  Bit Score: 497.60  E-value: 1.49e-172
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507681    16 DATCGPIKGVGYEQEDGSVVEGFLGIPYAEPPIGALRFKKPVAHRKWTEPLDCVRFGPRSPQNDELLGQFVNTVGKSEEh 95
Cdd:pfam00135   6 TTSLGRVRGKRLKVDGGKPVYAFLGIPYAEPPVGELRFQPPEPPEPWTGVRDATKFGPRCPQNGDLTSPGSSGLEGSED- 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507681    96 CLSLNVFTPKWESNEwPDGFPVMVFIHGGGFAVHSSSNYGCASIARNLctkDVVVVTINYRLGVLGFFTTGDEVCRGNLG 175
Cdd:pfam00135  85 CLYLNVYTPKELKEN-KNKLPVMVWIHGGGFMFGSGSLYDGSYLAAEG---DVIVVTINYRLGPLGFLSTGDDEAPGNYG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507681   176 LWDQTAALEWVQENIQSFRGDPDNVTIFGQSAGGASVDLLCLSPHSRGLFNRAIPMAGNGECDFAMRTSEQQAqlSREFA 255
Cdd:pfam00135 161 LLDQVLALRWVQENIASFGGDPNRVTLFGESAGAASVSLLLLSPLSKGLFHRAILMSGSALSPWAIQSNARQR--AKELA 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507681   256 RYLGWEGddNDSEDLLQFIDQQPLYKIEMgINPKRGFKHSqAGSLYFVPNFDGDFFPK-PLNQLRKE-APKMQIMTGTTK 333
Cdd:pfam00135 239 KLVGCPT--SDSAELVECLRSKPAEELLD-AQLKLLVYGS-VPFVPFGPVVDGDFLPEhPEELLKSGnFPKVPLLIGVTK 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507681   334 YEGLFFIALGALSKNPEGIK--KFMGRIFKECDYGERA---DDVLQMVYDFYFKGVHPKDHEKNMHQIVKFIGDYSINYG 408
Cdd:pfam00135 315 DEGLLFAAYILDNVDILKALeeKLLRSLLIDLLYLLLVdlpEEISAALREEYLDWGDRDDPETSRRALVELLTDYLFNCP 394

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507681   409 TYRLANIMTDLQHDVYFYQFDYHNSAGfgvfrWLLPFLGSTHCTEMRYVLGKGIISKFRPNDNDKKMLHVMTTYFTNFAK 488
Cdd:pfam00135 395 VIRFADLHASRGTPVYMYSFDYRGSSL-----RYPKWVGVDHGDELPYVFGTPFVGALLFTEEDEKLSRKMMTYWTNFAK 469

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*..
gi 17507681   489 YGNPNGENQETgEWQKHDSAHPfRHFKIDLdDSEMVEDYQERRAELW 535
Cdd:pfam00135 470 TGNPNGPEGLP-KWPPYTDENG-QYLSIDL-EPRVKQGLKAERCAFW 513
Esterase_lipase cd00312
Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on ...
 16-508 2.46e-142

Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These catalytic residues are responsible for the nucleophilic attack on the carbonyl carbon atom of the ester bond. In contrast with other alpha/beta hydrolase fold family members, p-nitrobenzyl esterase and acetylcholine esterase have a Glu instead of Asp at the active site carboxylate.


Pssm-ID: 238191 [Multi-domain]  Cd Length: 493  Bit Score: 419.81  E-value: 2.46e-142
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507681  16 DATCGPIKGVgyeQEDGsvVEGFLGIPYAEPPIGALRFKKPVAHRKWTEPLDCVRFGPRSPQNDELLGQFVNTVGKSEEH 95
Cdd:cd00312   3 VTPNGKVRGV---DEGG--VYSFLGIPYAEPPVGDLRFKEPQPYEPWSDVLDATSYPPSCMQWDQLGGGLWNAKLPGSED 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507681  96 CLSLNVFTPKweSNEWPDGFPVMVFIHGGGFAVHSSSNYGCASIARNLctKDVVVVTINYRLGVLGFFTTGDEVCRGNLG 175
Cdd:cd00312  78 CLYLNVYTPK--NTKPGNSLPVMVWIHGGGFMFGSGSLYPGDGLAREG--DNVIVVSINYRLGVLGFLSTGDIELPGNYG 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507681 176 LWDQTAALEWVQENIQSFRGDPDNVTIFGQSAGGASVDLLCLSPHSRGLFNRAIPMAGNGECDFAmrTSEQQAQLSREFA 255
Cdd:cd00312 154 LKDQRLALKWVQDNIAAFGGDPDSVTIFGESAGGASVSLLLLSPDSKGLFHRAISQSGSALSPWA--IQENARGRAKRLA 231

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507681 256 RYLGWegDDNDSEDLLQFIDQQPLYKIemgINPKRGFK-HSQAGSLYFVPNFDGDFFPKPLNQLRKE--APKMQIMTGTT 332
Cdd:cd00312 232 RLLGC--NDTSSAELLDCLRSKSAEEL---LDATRKLLlFSYSPFLPFGPVVDGDFIPDDPEELIKEgkFAKVPLIIGVT 306

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507681 333 KYEGLFFIALGaLSKNPEGIKKFMGRIFKECDYGE--RADDVLQMVYDFYFKGVhpKDHEKNMHQIVKFIGDYSINYGT- 409
Cdd:cd00312 307 KDEGGYFAAML-LNFDAKLIIETNDRWLELLPYLLfyADDALADKVLEKYPGDV--DDSVESRKNLSDMLTDLLFKCPAr 383

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507681 410 YRLANIMTDLQHDVYFYQFDYHNSagFGVFRWlLPFLGSTHCTEMRYVLGKGIISKFRPNDnDKKMLHVMTTYFTNFAKY 489
Cdd:cd00312 384 YFLAQHRKAGGSPVYAYVFDHRSS--LSVGRW-PPWLGTVHGDEIFFVFGNPLLKEGLREE-EEKLSRTMMKYWANFAKT 459

                       490
                ....*....|....*....
gi 17507681 490 GNPNGENQETgEWQKHDSA 508
Cdd:cd00312 460 GNPNTEGNLV-VWPAYTSE 477
PnbA COG2272
Carboxylesterase type B [Lipid transport and metabolism];
18-539 1.56e-135

Carboxylesterase type B [Lipid transport and metabolism];


Pssm-ID: 441873  Cd Length: 500  Bit Score: 402.73  E-value: 1.56e-135
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507681  18 TCGPIKGVgyeQEDGSVVegFLGIPYAEPPIGALRFKKPVAHRKWTEPLDCVRFGPRSPQNDELlGQFVNTVGKSEEhCL 97
Cdd:COG2272  18 EAGRVRGV---VEGGVRV--FLGIPYAAPPVGELRWRAPQPVEPWTGVRDATEFGPACPQPPRP-GDPGGPAPGSED-CL 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507681  98 SLNVFTPKWESNEwpdGFPVMVFIHGGGFAVHSSS--NYGCASIARnlctKDVVVVTINYRLGVLGFF-----TTGDEVC 170
Cdd:COG2272  91 YLNVWTPALAAGA---KLPVMVWIHGGGFVSGSGSepLYDGAALAR----RGVVVVTINYRLGALGFLalpalSGESYGA 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507681 171 RGNLGLWDQTAALEWVQENIQSFRGDPDNVTIFGQSAGGASVDLLCLSPHSRGLFNRAIPMAGNGecdFAMRTSEQQAQL 250
Cdd:COG2272 164 SGNYGLLDQIAALRWVRDNIAAFGGDPDNVTIFGESAGAASVAALLASPLAKGLFHRAIAQSGAG---LSVLTLAEAEAV 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507681 251 SREFARYLGWEgdDNDSEDLLQfIDQQPLYKIEMGINPKRGfkhsqaGSLYFVPNFDGDFFPK-PLNQLRK-EAPKMQIM 328
Cdd:COG2272 241 GAAFAAALGVA--PATLAALRA-LPAEELLAAQAALAAEGP------GGLPFGPVVDGDVLPEdPLEAFAAgRAADVPLL 311

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507681 329 TGTTKYEGLFFIALGALSK--NPEGIKKFMGRIFkecdyGERADDVLQmVYDfyfkGVHPKDheknmhQIVKFIGDYSIN 406
Cdd:COG2272 312 IGTNRDEGRLFAALLGDLGplTAADYRAALRRRF-----GDDADEVLA-AYP----AASPAE------ALAALATDRVFR 375

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507681 407 YGTYRLANIMTDLQHDVYFYQFDYHnSAGFGVFRwllpfLGSTHCTEMRYVLGKGIISKFRPNDN-DKKMLHVMTTYFTN 485
Cdd:COG2272 376 CPARRLAEAHAAAGAPVYLYRFDWR-SPPLRGFG-----LGAFHGAELPFVFGNLDAPALTGLTPaDRALSDQMQAYWVN 449

                       490       500       510       520       530
                ....*....|....*....|....*....|....*....|....*....|....
gi 17507681 486 FAKYGNPNGENQetGEWQKHDSAHPfRHFKIDLDDSEMVEDYQERRAELWDKLR 539
Cdd:COG2272 450 FARTGDPNGPGL--PEWPAYDPEDR-AVMVFDAEPRVVNDPDAEERLDLWDGVV 500
Aes COG0657
Acetyl esterase/lipase [Lipid transport and metabolism];
101-209 1.06e-15

Acetyl esterase/lipase [Lipid transport and metabolism];


Pssm-ID: 440422 [Multi-domain]  Cd Length: 207  Bit Score: 76.07  E-value: 1.06e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507681 101 VFTPKwesnEWPDGFPVMVFIHGGGFAVHSSSNYgcASIARNLC-TKDVVVVTINYRLGVLGFFTTGDEVCRgnlglwdq 179
Cdd:COG0657   3 VYRPA----GAKGPLPVVVYFHGGGWVSGSKDTH--DPLARRLAaRAGAAVVSVDYRLAPEHPFPAALEDAY-------- 68

                        90       100       110
                ....*....|....*....|....*....|
gi 17507681 180 tAALEWVQENIQSFRGDPDNVTIFGQSAGG 209
Cdd:COG0657  69 -AALRWLRANAAELGIDPDRIAVAGDSAGG 97
Abhydrolase_3 pfam07859
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 118-209 1.08e-10

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 400284 [Multi-domain]  Cd Length: 208  Bit Score: 61.46  E-value: 1.08e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507681   118 MVFIHGGGFAVHSSSNY--GCASIARNLctkDVVVVTINYRLGVLGFFTTGDEVCRgnlglwdqtAALEWVQENIQSFRG 195
Cdd:pfam07859   1 LVYFHGGGFVLGSADTHdrLCRRLAAEA---GAVVVSVDYRLAPEHPFPAAYDDAY---------AALRWLAEQAAELGA 68

                          90
                  ....*....|....
gi 17507681   196 DPDNVTIFGQSAGG 209
Cdd:pfam07859  69 DPSRIAVAGDSAGG 82
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
115-233 1.69e-08

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 55.41  E-value: 1.69e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507681 115 FPVMVFIHGGGfavhSSSNYGCASIARNLCTKDVVVVTINYRlgvlGFFTTGDEVcrGNLGLWDQTAALEWVQENiqsFR 194
Cdd:COG1506  23 YPVVVYVHGGP----GSRDDSFLPLAQALASRGYAVLAPDYR----GYGESAGDW--GGDEVDDVLAAIDYLAAR---PY 89

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 17507681 195 GDPDNVTIFGQSAGGASVdLLCLSPHSRgLFNRAIPMAG 233
Cdd:COG1506  90 VDPDRIGIYGHSYGGYMA-LLAAARHPD-RFKAAVALAG 126
BD-FAE pfam20434
BD-FAE; This family represents a novel bifunctional feruloyl and acetyl xylan esterase (BD-FAE, ...
 99-209 4.08e-08

BD-FAE; This family represents a novel bifunctional feruloyl and acetyl xylan esterase (BD-FAE, previously known as bifunctional carbohydrate esterase (CE)), which is active on complex natural xylans and was identified as the basis of a monophyletic clade gathering all homologs identified in PULs (polysaccharide utilization loci) predicted to act on xylan. It adopts an alpha-beta-hydrolase fold with the catalytic triad Ser-Asp-His. This new family of proteins is a new candidate for biomass processing due to its capacity to remove ferulic acid and acetic acid from natural corn and birchwood xylan substrates.


Pssm-ID: 466583 [Multi-domain]  Cd Length: 215  Bit Score: 53.72  E-value: 4.08e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507681    99 LNVFTPKWESNEwpdgFPVMVFIHGGGFAV---HSSSNYGCASIARnLCTKDVVVVTINYRLgvlgfftTGDEV------ 169
Cdd:pfam20434   1 LDIYLPKNAKGP----YPVVIWIHGGGWNSgdkEADMGFMTNTVKA-LLKAGYAVASINYRL-------STDAKfpaqiq 68

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 17507681   170 -CRgnlglwdqtAALEWVQENIQSFRGDPDNVTIFGQSAGG 209
Cdd:pfam20434  69 dVK---------AAIRFLRANAAKYGIDTNKIALMGFSAGG 100
COG4188 COG4188
Predicted dienelactone hydrolase [General function prediction only];
112-212 2.37e-05

Predicted dienelactone hydrolase [General function prediction only];


Pssm-ID: 443342 [Multi-domain]  Cd Length: 326  Bit Score: 46.64  E-value: 2.37e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507681 112 PDGFPVMVFIHGGGfavhsSSNYGCASIARNLCTKDVVVVTINY---RLGVLGFFTTGDEVCRGNLGLW----DQTAALE 184
Cdd:COG4188  59 GGPFPLVVLSHGLG-----GSREGYAYLAEHLASHGYVVAAPDHpgsNAADLSAALDGLADALDPEELWerplDLSFVLD 133

                        90       100       110
                ....*....|....*....|....*....|...
gi 17507681 185 WVQE---NIQSFRG--DPDNVTIFGQSAGGASV 212
Cdd:COG4188 134 QLLAlnkSDPPLAGrlDLDRIGVIGHSLGGYTA 166
COG4099 COG4099
Predicted peptidase [General function prediction only];
100-235 5.64e-04

Predicted peptidase [General function prediction only];


Pssm-ID: 443275 [Multi-domain]  Cd Length: 235  Bit Score: 41.49  E-value: 5.64e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507681 100 NVFTPK-WESNEwpdGFPVMVFIHGGGFA--------VHSSSNYGCASIARNLctkDVVVVTINYRLGvlGFFTTGDEVc 170
Cdd:COG4099  36 RLYLPKgYDPGK---KYPLVLFLHGAGERgtdnekqlTHGAPKFINPENQAKF---PAIVLAPQCPED--DYWSDTKAL- 106

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17507681 171 rgnlglwdqTAALEWVQENIQSFRGDPDNVTIFGQSAGG-ASVDLLCLSPHsrgLFNRAIPMAGNG 235
Cdd:COG4099 107 ---------DAVLALLDDLIAEYRIDPDRIYLTGLSMGGyGTWDLAARYPD---LFAAAVPICGGG 160
Peptidase_S9 pfam00326
Prolyl oligopeptidase family;
143-233 4.51e-03

Prolyl oligopeptidase family;


Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 38.75  E-value: 4.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507681   143 LCTKDVVVVTINYRLGvlGFFttGDE---VCRGNLGLW---DQTAALEWVQENiqsFRGDPDNVTIFGQSAGGASVdLLC 216
Cdd:pfam00326  10 LADRGYVVAIANGRGS--GGY--GEAfhdAGKGDLGQNefdDFIAAAEYLIEQ---GYTDPDRLAIWGGSYGGYLT-GAA 81

                          90
                  ....*....|....*..
gi 17507681   217 LSPHSRgLFNRAIPMAG 233
Cdd:pfam00326  82 LNQRPD-LFKAAVAHVP 97
Fes COG2382
Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];
99-233 9.74e-03

Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];


Pssm-ID: 441948 [Multi-domain]  Cd Length: 314  Bit Score: 38.30  E-value: 9.74e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17507681  99 LNVFTPKWESNEWPDgFPVMVFIHGGGFAVHSSSNYGCA-SIARNLCT----KDVVVVTINYRLGVlgfFTTGDEVCRGN 173
Cdd:COG2382  97 VWVYLPPGYDNPGKK-YPVLYLLDGGGGDEQDWFDQGRLpTILDNLIAagkiPPMIVVMPDGGDGG---DRGTEGPGNDA 172

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17507681 174 LGLWDQTAALEWVQENIqSFRGDPDNVTIFGQSAGG-ASVDLLCLSPHsrgLFNRAIPMAG 233
Cdd:COG2382 173 FERFLAEELIPFVEKNY-RVSADPEHRAIAGLSMGGlAALYAALRHPD---LFGYVGSFSG 229
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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