MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane and are capable of cleaving growth factors, extracellular matrix proteins, and biologically active peptides. TRAF molecules serve as adapter proteins that link cell surface receptors of the Tumor Necrosis Factor and 1nterleukin-1/Toll-like families to downstream kinase cascades, which results in the activation of transcription factors and the regulation of cell survival, proliferation and stress responses in the immune and inflammatory systems. Other members include the ubiquitin ligases, TRIM37 and SPOP, and the ubiquitin-specific proteases, HAUSP and Ubp21p. A large number of uncharacterized members mostly from lineage-specific expansions in C. elegans and rice contain MATH and BTB domains, similar to SPOP. The MATH domain has been shown to bind peptide/protein substrates in TRAFs and HAUSP. It is possible that the MATH domain in other members of this superfamily also interacts with various protein substrates. The TRAF domain may also be involved in the trimerization of TRAFs. Based on homology, it is postulated that the MATH domain in meprins may be involved in its tetramer assembly and that the MATH domain, in general, may take part in diverse modular arrangements defined by adjacent multimerization domains.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 17531219     5 HSVTRNAKNSFgtgNETSSWGWSPFINWNEMIDDYLIGDTITIEATVRI 53
Cdd:pfam00917  68 KSVTKTDTHVF---EKPKGWGWGKFISWDDLEKDYLVDDSITVEAHVKI 113

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531219     76 DVVVAVGNEKFYVLKVYLASHSTYFKTLFLGKFVEADKSEVTLQDIDPTDFQCLMEVIH-GESAIDDSTIDGVLQLAQMF 154
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYtGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|....*..
gi 17531219    155 DVSLAIRKSEEFLVEKS 171
Cdd:smart00225  81 QIPGLVELCEEFLLKLL 97

MATH domain; This motif has been called the Meprin And TRAF-Homology (MATH) domain. This domain is hugely expanded in the nematode C. elegans.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 17531219     5 HSVTRNAKNSFgtgNETSSWGWSPFINWNEMIDDYLIGDTITIEATVRI 53
Cdd:pfam00917  68 KSVTKTDTHVF---EKPKGWGWGKFISWDDLEKDYLVDDSITVEAHVKI 113

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531219     76 DVVVAVGNEKFYVLKVYLASHSTYFKTLFLGKFVEADKSEVTLQDIDPTDFQCLMEVIH-GESAIDDSTIDGVLQLAQMF 154
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYtGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|....*..
gi 17531219    155 DVSLAIRKSEEFLVEKS 171
Cdd:smart00225  81 QIPGLVELCEEFLLKLL 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17531219  77 VVVAVGNEKFYVLKVYLASHSTYFKTLFLGKFVEADKSEVTLQDIDPTDFQCLMEVIHGESAIDD-STIDGVLQLAQMF 154
Cdd:cd01165   1 VVLVVEGEKFHVNKELLAQSSEYFRALFRGGFRESGQAEINLRDISPEDFRALLEFLYGGKRDLDaSNLLELLEAANFL 79

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531219  71 NEEFSDVVVAVGNEKFYVLKVYLASHSTYFKTLFLGKFVEADKSEVTLQDIDPTDFQCLMEVIH-GESAIDDSTIDGVLQ 149
Cdd:cd18314   3 DSEFSDVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIESNLKEVTLEDVEPEIFETVLKYMYtGQVTLSEENVLDLLM 82

                ....*...
gi 17531219 150 LAQMFDVS 157
Cdd:cd18314  83 LASKYQVP 90

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531219  73 EFSDVVVAVGNEKFYVLKVYLASHSTYFKTLFLGKFVEADKSEVTLQDIDPTDFQCLMEVIH-GESAIDDSTIDGVLQLA 151
Cdd:cd18256  19 EFCDVQLQVGMELFSVHRLVLAASSPYFAALFAGGMSESSKDVVQIHGVEPDIFHILLDFIYtGVVEVTVSNVQELLVAA 98

                        90
                ....*....|....*.
gi 17531219 152 QMFDVSLAIRKSEEFL 167
Cdd:cd18256  99 DMLQLTEVVEICCEFL 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531219  64 LKSFDEsNEEFSDVVVAVGNEKFYVLKVYLASHSTYFKTLFLGKFVEADKSEVTLQDIDPTDFQCLMEVIH-GESAIDDS 142
Cdd:cd18270  17 LKFFYE-QQLLTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRNVDAATLQIIITYAYtGNLAINDS 95

                        90       100
                ....*....|....*....|....*...
gi 17531219 143 TIDGVLQLAQMFDVSLAIRKSEEFLVEK 170
Cdd:cd18270  96 TVEQLYETACFLQVEDVLQRCREYLIKK 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531219  74 FSDVVVAVGNEKFYVLKVYLASHSTYFKTLFLGKFVEADKSEVTLQDIDPTDFQCLMEVIHGES-AIDDSTIDGVLQLAQ 152
Cdd:cd18265  23 FTDVVLLVDGKDFPCHRATLSANSAYFRAMFGGHLKESRQAVVEIQKVSAAAMEVLLDYMYGGGlRIQEDNVESVLEASD 102

                ....*
gi 17531219 153 MFDVS 157
Cdd:cd18265 103 LLQVS 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17531219  70 SNEEFSDVVVAVGNEKFYVLKVYLASHSTYFKTLFLGKFVEADKSEVTLQDIDPTDFQCLME 131
Cdd:cd18249  19 KHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVTIRDIDERAMELLID 80

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531219  71 NEEFSDVVVAVGNEKFYVLKVYLASHSTYFKTLFLGKFVEADKSEVTLQDIDPTDFQCLMEVIHGESAIDDSTIDGVLQL 150
Cdd:cd18280  11 SEEGADVTFNVDGEKFRAHKLVLAARSPVFRSMLFGPMREENEGEIVIEDVEPPVFKALLHFIYKDELPDDVEPAGSDSS 90

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 17531219 151 AqmFDVSLAIRkseeflvekskksmrdLLKLAKQFQLENLKTVCLSKI 198
Cdd:cd18280  91 S--LDTTMAQH----------------LLAAADRYALERLRLLCESRL 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531219  71 NEEFSDVVVAVGNEKFYVLKVYLASHSTYFKTLFLGKFVEADKSEVTLQDIDPTDFQCLMEVIH--GESAIDDSTIDGVl 148
Cdd:cd18297   9 NPEMSDVTFLVEGRPFYAHKIVLVTASDRFKSMLSSGSTEAQTPVIEIPDIRYDIFQLMMQYLYtgGVESLDVAQDDAL- 87

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 17531219 149 qlaqmfdvslairkseeflvekskksmrDLLKLAKQFQLENLKTVC 194
Cdd:cd18297  88 ----------------------------ELLRAASFFQLDGLKRHC 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531219  70 SNEEFSDVVVAVGNEKFYVLKVYLASHSTYFKTLFLGKFVEADKSEVTLQDIDPTDFQCLMEVIH-GESAIDDSTIDGVL 148
Cdd:cd18259  28 SNPKLSDVTLLVGGREFPCHRSVLALCSHYFNAMFTGDFVESISARVEIKDVDPAVMESLIDFAYtGKLTINQGNVEALI 107

                        90
                ....*....|....
gi 17531219 149 QLAQMFDVSlAIRK 162
Cdd:cd18259 108 RTSNRLQFP-TVRK 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531219  76 DVVVAVGNEKFYVLKVYLASHSTYFKTLFLGKFVEADKSEVTLQDIDPTDFQCLMEVIH-GESAIDDSTIDGVLQLAQMF 154
Cdd:cd18247  21 DVTLKVGDQKFSAHRIVLAATIPYFHAMFTHDMVESKQDEITMQGIEPSALEALINFAYsGRIAIDTSNVQSLLVGASFL 100

                        90
                ....*....|....*.
gi 17531219 155 DVSLAIRKSEEFLVEK 170
Cdd:cd18247 101 QLQSVKDACCEFLKER 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531219  71 NEEFSDVVVAVGNEKFYVLKVYLaSHSTYFKTLFLGKFVEADKSEVTLQDIDPT-DFQCLMEVI----HGESAIDDSTID 145
Cdd:cd18305  12 NGENSDITICALGREWKLHKIYL-CQSGYFASMFSGSWKESKETVINLEIPDDNiTVEALNVVFgslyRDEIEIKPSRVV 90

                        90       100
                ....*....|....*....|....
gi 17531219 146 GVLQLAQMFDVSLAIRKSEEFLVE 169
Cdd:cd18305  91 SILAAATLLQLDGLIQQCSEVMKE 114

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531219  71 NEEFSDVVVAVGNEKFYVLKVYLASHSTYFKTLFLGKFVEADKSEVTLQDIDPTDFQCLMEVIHG--ESAIDDSTIDGVL 148
Cdd:cd18286  14 NGEDSDITIKVDGKTFKAHRCILCARSSYFAAMLSGSWAESNSSEITLTGVSHAAVSFVLLFIYGgvLDLPDDVNLGELL 93

                ....*...
gi 17531219 149 QLAQMFDV 156
Cdd:cd18286  94 SLADMYGL 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531219  75 SDVVVAVGNEKFYVLKVYLASHSTYFKTLFLGKFVEADKSEVTLQDIDPTDFQCLMEVIH-GESAIDDSTIDGVLQLAQM 153
Cdd:cd18234   2 CDVILIAGDRRIPAHRLVLSAVSDYFAAMFTNDVREATEEEIKLKDVDPDALWTLVQYCYtGRLELKEDNVESLLATACL 81

                        90
                ....*....|....*
gi 17531219 154 FDVSLAIRKSEEFLV 168
Cdd:cd18234  82 LQLSEVVEACCGFLM 96

MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane and are capable of cleaving growth factors, extracellular matrix proteins, and biologically active peptides. TRAF molecules serve as adapter proteins that link cell surface receptors of the Tumor Necrosis Factor and 1nterleukin-1/Toll-like families to downstream kinase cascades, which results in the activation of transcription factors and the regulation of cell survival, proliferation and stress responses in the immune and inflammatory systems. Other members include the ubiquitin ligases, TRIM37 and SPOP, and the ubiquitin-specific proteases, HAUSP and Ubp21p. A large number of uncharacterized members mostly from lineage-specific expansions in C. elegans and rice contain MATH and BTB domains, similar to SPOP. The MATH domain has been shown to bind peptide/protein substrates in TRAFs and HAUSP. It is possible that the MATH domain in other members of this superfamily also interacts with various protein substrates. The TRAF domain may also be involved in the trimerization of TRAFs. Based on homology, it is postulated that the MATH domain in meprins may be involved in its tetramer assembly and that the MATH domain, in general, may take part in diverse modular arrangements defined by adjacent multimerization domains.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 17531219   6 SVTRNAKNSFGTGNETSsWGWSPFINWNEMIDDY-LIGDTITIEATVR 52
Cdd:cd00121  80 SLSKSFTHVFFSEKGSG-WGFPKFISWDDLEDSYyLVDDSLTIEVEVK 126

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531219  76 DVVVAVGNEKFYVLKVYLASHSTYFKTLFLGKFVEADKSEVTLQDIDPTDFQCLMEVIH-GESAIDDSTIDGVLQLAQMF 154
Cdd:cd18246  41 DIVLHVGTKEIKAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQALEQLVQYAYtAEIVVGEGNVQTLLPAASLL 120

                ...
gi 17531219 155 DVS 157
Cdd:cd18246 121 QLN 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531219  59 FSKKVLKSFDESNEE--FSDVVVAVGNEKFYVLKVYLASHSTYFKTLFLGKFVEADKSEVTLQDIDPTDFQCLMEVIH-G 135
Cdd:cd18268   6 LSSELLRQLNSLRQEriLTDVILCTGDKEIPCHRNVLASSSPYFRAMFCNNFRESSQAKVDLKGIDSDVLDQIVDYVYtG 85

                        90
                ....*....|....*..
gi 17531219 136 ESAIddsTIDGVLQLAQ 152
Cdd:cd18268  86 EILI---TRDNVLPLME 99

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531219  71 NEEFSDVVVAVGNEKFYVLKVYLASHSTYFKTLFLGKFVEADKSEVTLQDIDPTDFQCLMEVI-HGESAIDDSTIDGVLQ 149
Cdd:cd18272  29 DGLFADVTISVEGKEFQLHRLVLSAQSCFFRSMFTSNLKEARNRVIELKDVSESVFQLLVDYIyHGTVKLRVEELQETYE 108

                        90
                ....*....|....*....
gi 17531219 150 LAQMFDVSLAIRKSEEFLV 168
Cdd:cd18272 109 VADMYQLTALFEECSRFLA 127

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531219  65 KSFDESNE-----EFSDVVVAVGNEKFYVLKVYLASHSTYFKTLFLGKFVEADKSEVTLQDIDPTDFQCLMEVIHgeSAI 139
Cdd:cd18235   7 KAFDVMNElrkqnLLCDVILVADGVEIPAHRVVLASCSPYFHAMFTGDLSESRANRVTLQDVDGKALLLLIDYVY--TAE 84

                        90       100
                ....*....|....*....|...
gi 17531219 140 DDSTIDGV------LQLAQMFDV 156
Cdd:cd18235  85 IQVTEENVqvllpaANLLQLTDV 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531219  71 NEEFSDVVVAVGNEKFYVLKVYLASHSTYFKTLFLGKFVEADKSEVTLQDIDPTDFQCLMEVIH-GESAIDDSTIDGVLQ 149
Cdd:cd18336  16 HKQLCDVLLIAGNLKIPAHRLVLSAVSDYFAAMFTNDVREAKQEEIKMEGVDPDALKALVHYAYtGVLELKEDTIESLLA 95

                        90       100
                ....*....|....*....|.
gi 17531219 150 LAQMFDVSLAIRKSEEFLVEK 170
Cdd:cd18336  96 AACLLQLSQVIDVCCNFLMKQ 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 13 (KBTBD13); KBTBD13 is a muscle specific protein. Its autosomal dominant mutations may cause Nemaline Myopathy (NEM). KBTBD13 may act as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that functions as a muscle specific ubiquitin ligase, and thereby implicating the ubiquitin proteasome pathway in the pathogenesis of KBTBD13-associated NEM. KBTBD13 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17531219  77 VVVAVGNEKFYVLKVYLASHSTYFKTLFLGKFVEADKSEVTLQDIDPTDFQCLMEVIHGESAI--DDSTIDGV 147
Cdd:cd18320   4 VKVWVEEQLFTVDKALLVENSEYFRALFRSGMRECTQDEIRLQGLSARGFRIMLRVLAGERPIlnGEEILQAI 76

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531219  73 EFSDVVVAVGNEKFYVLKVYLASHSTYFKTLFLGKFveADKSEVTLQD--IDPTDFQCLMEVI---HGESAIDDstidgv 147
Cdd:cd18295  18 SYSDVTFNVHGESFPAHRCILSARSPYFAEMFETKW--KDKREINLKHplVNPDAFRALLQYLytgRLEIHVDD------ 89

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 17531219 148 lqlaqmfdvslairkseeflvekskksMRDLLKLAKQFQLENLK 191
Cdd:cd18295  90 ---------------------------VEDCKRLAKQCRLEELI 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531219  72 EEFSDVVVAVGNEKFYVLKVYLASHSTYFKTLFLGKFVEADKSEVTLQDIDPTDFQCLMEVIH-GESAIDDSTIDGVLQL 150
Cdd:cd18335  17 QQLCDVILIAGNRKIPAHRLVLSAVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYtGCLELKEDTIENLLAA 96

                        90
                ....*....|....*....
gi 17531219 151 AQMFDVSLAIRKSEEFLVE 169
Cdd:cd18335  97 ACLLQLSQVVEVCCHFLMK 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531219  64 LKSFDESNEeFSDVVVAVGNEKFYVLKVYLASHSTYFKTLFLGKFVEADKSEVTLQDIDPtdfqclmevihgesaiddST 143
Cdd:cd18341  18 LKELLDENK-FVDCTLKAGDKSLPCHRLILAACSPYFREYFLSEESEEKKKEVVLDNVDP------------------NI 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 17531219 144 IDGVLQLAQMFDVSLairkseeflvekSKKSMRDLLKLAKQFQLENLKTVCLS 196
Cdd:cd18341  79 MDMILKYLYSAEIDL------------NDGNVQDIFALASRFQIPSVFTVCVT 119

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531219  70 SNEEFSDVVVAVGNEKFYVLKVYLASHSTYFKTLFLGKFVEADKSEVTLQDIDPTDFQCLMEVIHGESaiddstidgvlq 149
Cdd:cd18352   9 NNATLSDVTFLVEGRRFYAHRIALLASSDAFRAMFDGGYREKEARDIEIPNIRWEVFELMMRFIYTGS------------ 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 17531219 150 laqmfdvslairkseeflVEKSKKSMRDLLKLAKQFQLENLKTVC 194
Cdd:cd18352  77 ------------------VDITNDIAKDLLRAADQYLLEGLKRLC 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531219  76 DVVVAVGNEKFYVLKVYLASHSTYFKTLFLGKFVEADKSEVTLQDIDPTDFQCLMEVI-HGESAIDDSTIDGVLQLAQMF 154
Cdd:cd18244  32 DVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSHVLQFMyYGTIELSMLTVHEILQAAMYV 111

                        90
                ....*....|....*.
gi 17531219 155 DVSLAIRKSEEFLVEK 170
Cdd:cd18244 112 QLTEVVKFCCSFLLAK 127

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2); ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins with various functions ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, with implications for Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homolog (PTEN). It contains an ankyrin repeat, BTB/POZ, and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531219  70 SNEEFSDVVVAVGNEKFYVLKVYLASHSTYFKTLFLGKFVEADKSEVTLQ--DIDPTDFQCLMEVIH--GESAIDDSTID 145
Cdd:cd18350  20 NNKEMSDVTFLVEGKLFYAHKVLLVTASNRFKSLLTNKSEQESQGSKTIEisDIKYHIFQMLMQYLYygGTESMEIPIAD 99

                        90       100
                ....*....|....*....|..
gi 17531219 146 gVLQL---AQMFDVSLAIRKSE 164
Cdd:cd18350 100 -VLELlsaASLFQLDALQRHCE 120

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531219  74 FSDVVVAVGNEKFYVLKVYLASHSTYFKTLFlGKFVEADKSEVTLQDIDPTDFQCLMEVI-HGESAIDDSTIDGVLQLAQ 152
Cdd:cd18315   1 LVDVTLACEGGSLKAHKLVLAAASPYFAALL-KETPPDEHPVIILPDVPYSELKALLDFIyTGEVNVSQEQLESLLKLAE 79