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Conserved domains on  [gi|71993236|ref|NP_497075|]
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Cadherin domain-containing protein [Caenorhabditis elegans]

Protein Classification

cadherin repeat domain-containing protein( domain architecture ID 10182011)

cadherin repeat domain-containing protein similar to Homo sapiens desmoglein-2, which is involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion; cadherins are are calcium-dependent cell adhesion proteins that preferentially interact with themselves in connecting cells

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  17158740|28268172|27782885|11736639
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 939-1033 1.80e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 90.45  E-value: 1.80e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993236  939 EQTVEIPEDAPLNTVVATVKATEGDESQ--EVFYHLKAGSPPQ-FSLNSKTGEVMVEQALDREALDNFEIEIGASNSVDL 1015
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGEngEVTYSIVSGNEDGlFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                         90
                 ....*....|....*...
gi 71993236 1016 IGTAAMKLLVKVKDVNDN 1033
Cdd:cd11304   81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 842-931 4.30e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 69.26  E-value: 4.30e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993236  842 FYVRENTPIDTVIGKVSA-DVLPGKCA-LEYSIIGPN-SEILSINSANGELKTSKEFDFEKQKSYLLTLKLVAGKYNSVE 918
Cdd:cd11304    4 VSVPENAPPGTVVLTVSAtDPDSGENGeVTYSIVSGNeDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                         90
                 ....*....|....*
gi 71993236  919 SGAELKI--LDVDDH 931
Cdd:cd11304   84 STATVTItvLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 232-319 9.65e-06

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 45.38  E-value: 9.65e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993236  232 YQTTIEEHTGEQDHLVKISTK----GGSSEVLYSLR--DASGLFSIHPKEGILSILHP-EFLSISSFgdtvNLTVVATDG 304
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATdpdsGENGEVTYSIVsgNEDGLFSIDPSTGEITTAKPlDREEQSSY----TLTVTATDG 77

                         90
                 ....*....|....*...
gi 71993236  305 D---KTADAMINVKIVPE 319
Cdd:cd11304   78 GgppLSSTATVTITVLDV 95
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 939-1033 1.80e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 90.45  E-value: 1.80e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993236  939 EQTVEIPEDAPLNTVVATVKATEGDESQ--EVFYHLKAGSPPQ-FSLNSKTGEVMVEQALDREALDNFEIEIGASNSVDL 1015
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGEngEVTYSIVSGNEDGlFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                         90
                 ....*....|....*...
gi 71993236 1016 IGTAAMKLLVKVKDVNDN 1033
Cdd:cd11304   81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 842-931 4.30e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 69.26  E-value: 4.30e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993236  842 FYVRENTPIDTVIGKVSA-DVLPGKCA-LEYSIIGPN-SEILSINSANGELKTSKEFDFEKQKSYLLTLKLVAGKYNSVE 918
Cdd:cd11304    4 VSVPENAPPGTVVLTVSAtDPDSGENGeVTYSIVSGNeDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                         90
                 ....*....|....*
gi 71993236  919 SGAELKI--LDVDDH 931
Cdd:cd11304   84 STATVTItvLDVNDN 98
Cadherin pfam00028
Cadherin domain;
940-1012 1.27e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 59.24  E-value: 1.27e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 71993236    940 QTVEIPEDAPLNTVVATVKATEGDESQE--VFYHLKAGSPPQ-FSLNSKTGEVMVEQALDREALDNFEIEIGASNS 1012
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNgrIFYSILGGGPGGnFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 958-1035 1.29e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 58.90  E-value: 1.29e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993236     958 KATEGDE--SQEVFYHLKAGSPPQ-FSLNSKTGEVMVEQALDREALDNFEIEIGASNSVDLIGTAAMKLLVKVKDVNDNG 1034
Cdd:smart00112    1 SATDADSgeNGKVTYSILSGNDDGlFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 71993236    1035 P 1035
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 868-931 4.70e-06

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 45.80  E-value: 4.70e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 71993236     868 LEYSIIGPN-SEILSINSANGELKTSKEFDFEKQKSYLLTLKLV--AGKYNSVESGAELKILDVDDH 931
Cdd:smart00112   13 VTYSILSGNdDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATdgGGPPLSSTATVTITVLDVNDN 79
Cadherin pfam00028
Cadherin domain;
842-925 6.39e-06

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 45.75  E-value: 6.39e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993236    842 FYVRENTPIDTVIGKVSA---DVLPGKcALEYSIIGPNSE-ILSINSANGELKTSKEFDFEKQKSYLLTLKLVAGKYNSV 917
Cdd:pfam00028    3 ASVPENAPVGTEVLTVTAtdpDLGPNG-RIFYSILGGGPGgNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPL 81


                   ....*...
gi 71993236    918 ESGAELKI 925
Cdd:pfam00028   82 SSTATVTI 89
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 232-319 9.65e-06

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 45.38  E-value: 9.65e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993236  232 YQTTIEEHTGEQDHLVKISTK----GGSSEVLYSLR--DASGLFSIHPKEGILSILHP-EFLSISSFgdtvNLTVVATDG 304
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATdpdsGENGEVTYSIVsgNEDGLFSIDPSTGEITTAKPlDREEQSSY----TLTVTATDG 77

                         90
                 ....*....|....*...
gi 71993236  305 D---KTADAMINVKIVPE 319
Cdd:cd11304   78 GgppLSSTATVTITVLDV 95
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 939-1033 1.80e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 90.45  E-value: 1.80e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993236  939 EQTVEIPEDAPLNTVVATVKATEGDESQ--EVFYHLKAGSPPQ-FSLNSKTGEVMVEQALDREALDNFEIEIGASNSVDL 1015
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGEngEVTYSIVSGNEDGlFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                         90
                 ....*....|....*...
gi 71993236 1016 IGTAAMKLLVKVKDVNDN 1033
Cdd:cd11304   81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 842-931 4.30e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 69.26  E-value: 4.30e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993236  842 FYVRENTPIDTVIGKVSA-DVLPGKCA-LEYSIIGPN-SEILSINSANGELKTSKEFDFEKQKSYLLTLKLVAGKYNSVE 918
Cdd:cd11304    4 VSVPENAPPGTVVLTVSAtDPDSGENGeVTYSIVSGNeDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                         90
                 ....*....|....*
gi 71993236  919 SGAELKI--LDVDDH 931
Cdd:cd11304   84 STATVTItvLDVNDN 98
Cadherin pfam00028
Cadherin domain;
940-1012 1.27e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 59.24  E-value: 1.27e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 71993236    940 QTVEIPEDAPLNTVVATVKATEGDESQE--VFYHLKAGSPPQ-FSLNSKTGEVMVEQALDREALDNFEIEIGASNS 1012
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNgrIFYSILGGGPGGnFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 958-1035 1.29e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 58.90  E-value: 1.29e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993236     958 KATEGDE--SQEVFYHLKAGSPPQ-FSLNSKTGEVMVEQALDREALDNFEIEIGASNSVDLIGTAAMKLLVKVKDVNDNG 1034
Cdd:smart00112    1 SATDADSgeNGKVTYSILSGNDDGlFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 71993236    1035 P 1035
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 868-931 4.70e-06

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 45.80  E-value: 4.70e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 71993236     868 LEYSIIGPN-SEILSINSANGELKTSKEFDFEKQKSYLLTLKLV--AGKYNSVESGAELKILDVDDH 931
Cdd:smart00112   13 VTYSILSGNdDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATdgGGPPLSSTATVTITVLDVNDN 79
Cadherin pfam00028
Cadherin domain;
842-925 6.39e-06

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 45.75  E-value: 6.39e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993236    842 FYVRENTPIDTVIGKVSA---DVLPGKcALEYSIIGPNSE-ILSINSANGELKTSKEFDFEKQKSYLLTLKLVAGKYNSV 917
Cdd:pfam00028    3 ASVPENAPVGTEVLTVTAtdpDLGPNG-RIFYSILGGGPGgNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPL 81


                   ....*...
gi 71993236    918 ESGAELKI 925
Cdd:pfam00028   82 SSTATVTI 89
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 232-319 9.65e-06

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 45.38  E-value: 9.65e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993236  232 YQTTIEEHTGEQDHLVKISTK----GGSSEVLYSLR--DASGLFSIHPKEGILSILHP-EFLSISSFgdtvNLTVVATDG 304
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATdpdsGENGEVTYSIVsgNEDGLFSIDPSTGEITTAKPlDREEQSSY----TLTVTATDG 77

                         90
                 ....*....|....*...
gi 71993236  305 D---KTADAMINVKIVPE 319
Cdd:cd11304   78 GgppLSSTATVTITVLDV 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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