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Conserved domains on  [gi|17554020|ref|NP_497275|]
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MICOS complex subunit MIC27 [Caenorhabditis elegans]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ApoO super family cl10749
Apolipoprotein O; Members of this family promote cholesterol efflux from macrophage cells. ...
 64-165 2.38e-10

Apolipoprotein O; Members of this family promote cholesterol efflux from macrophage cells. They are present in various lipoprotein complexes, including HDL, LDL and VLDL. The apoprotein is secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL.


The actual alignment was detected with superfamily member pfam09769:

Pssm-ID: 462891  Cd Length: 131  Bit Score: 56.02  E-value: 2.38e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554020    64 PEEPLPLQREFATIRIACEQEYDRVAERFKVVDCAMTQTKKAATKCNAYLTEEW-TALPKAAAITVGGMAGFVLGLKRGP 142
Cdd:pfam09769  10 PTPTDRLEEGVRSARLFLYPYASAAEDELNTVKSKYFNAEQSFTSTIASLAPPPeDLLPGLIYILVAGLAGSILARRRSI 89

                          90       100
                  ....*....|....*....|...
gi 17554020   143 VGRLLTTTIGLATMAAFCYPIEA 165
Cdd:pfam09769  90 LKRFAYPLAFGGAAASYFLPQTF 112
 
Name Accession Description Interval E-value
ApoO pfam09769
Apolipoprotein O; Members of this family promote cholesterol efflux from macrophage cells. ...
 64-165 2.38e-10

Apolipoprotein O; Members of this family promote cholesterol efflux from macrophage cells. They are present in various lipoprotein complexes, including HDL, LDL and VLDL. The apoprotein is secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL.


Pssm-ID: 462891  Cd Length: 131  Bit Score: 56.02  E-value: 2.38e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554020    64 PEEPLPLQREFATIRIACEQEYDRVAERFKVVDCAMTQTKKAATKCNAYLTEEW-TALPKAAAITVGGMAGFVLGLKRGP 142
Cdd:pfam09769  10 PTPTDRLEEGVRSARLFLYPYASAAEDELNTVKSKYFNAEQSFTSTIASLAPPPeDLLPGLIYILVAGLAGSILARRRSI 89

                          90       100
                  ....*....|....*....|...
gi 17554020   143 VGRLLTTTIGLATMAAFCYPIEA 165
Cdd:pfam09769  90 LKRFAYPLAFGGAAASYFLPQTF 112
 
Name Accession Description Interval E-value
ApoO pfam09769
Apolipoprotein O; Members of this family promote cholesterol efflux from macrophage cells. ...
 64-165 2.38e-10

Apolipoprotein O; Members of this family promote cholesterol efflux from macrophage cells. They are present in various lipoprotein complexes, including HDL, LDL and VLDL. The apoprotein is secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL.


Pssm-ID: 462891  Cd Length: 131  Bit Score: 56.02  E-value: 2.38e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554020    64 PEEPLPLQREFATIRIACEQEYDRVAERFKVVDCAMTQTKKAATKCNAYLTEEW-TALPKAAAITVGGMAGFVLGLKRGP 142
Cdd:pfam09769  10 PTPTDRLEEGVRSARLFLYPYASAAEDELNTVKSKYFNAEQSFTSTIASLAPPPeDLLPGLIYILVAGLAGSILARRRSI 89

                          90       100
                  ....*....|....*....|...
gi 17554020   143 VGRLLTTTIGLATMAAFCYPIEA 165
Cdd:pfam09769  90 LKRFAYPLAFGGAAASYFLPQTF 112
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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