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Conserved domains on  [gi|115534077|ref|NP_497378|]
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F-box domain-containing protein [Caenorhabditis elegans]

Protein Classification

F-box protein( domain architecture ID 17778750)

F-box protein is the substrate-recognition component of a SCF(Skp1-cullin-F-box) E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins; similar to Caenorhabditis elegans F-box domain-containing protein

Gene Ontology:  GO:0000209|GO:0031146|GO:0019005|GO:0005515
PubMed:  10581972|31898225

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FTH pfam01827
FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is ...
 123-262 8.37e-37

FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is found in many proteins from C. elegans. The domain is found associated with the F-box pfam00646. This domain is named FTH after FOG-2 homology domain.


:

Pssm-ID: 396410  Cd Length: 141  Bit Score: 128.08  E-value: 8.37e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115534077  123 KNFDALTDRLQAVKPLDVECLLLTDLSLAQCAHLLPFFEAGKLERIAINNdEEEFNKFEEITVLEQWKKAKRLHLNpykG 202
Cdd:pfam01827   2 KIIESFLNILKSKKCLHVKEISLSGLSFSEVASILPYFDAGTLEEIELSS-ESDEDQFEEIVELEQWKNAKSLKIE---G 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 115534077  203 FDTSSVSIESFFHCKWFSITVLTISAQDARKIEEILLKNEHFTGCDI--KCWTLPVMTEIFQ 262
Cdd:pfam01827  78 SSLSSFPIEHLFHFEEFDIKLDSFSVEDAIKIRDILLKSSTFQSCTIrsPDLNPIEIAKVFD 139
F-box_CeFBXA-like cd22150
F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and ...
 1-39 1.74e-09

F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and similar proteins; The family includes a group of uncharacterized Caenorhabditis elegans F-box domain-containing proteins. They may be components of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438921  Cd Length: 46  Bit Score: 52.49  E-value: 1.74e-09
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 115534077   1 MPIEIIHETLQKMEPRNRLTLRKVSRNLRLAVDHHGIGF 39
Cdd:cd22150    4 LPIEILNKILDKLDPIDRLVLRKVSRNLRDIVDNQDPGF 42
 
Name Accession Description Interval E-value
FTH pfam01827
FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is ...
 123-262 8.37e-37

FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is found in many proteins from C. elegans. The domain is found associated with the F-box pfam00646. This domain is named FTH after FOG-2 homology domain.


Pssm-ID: 396410  Cd Length: 141  Bit Score: 128.08  E-value: 8.37e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115534077  123 KNFDALTDRLQAVKPLDVECLLLTDLSLAQCAHLLPFFEAGKLERIAINNdEEEFNKFEEITVLEQWKKAKRLHLNpykG 202
Cdd:pfam01827   2 KIIESFLNILKSKKCLHVKEISLSGLSFSEVASILPYFDAGTLEEIELSS-ESDEDQFEEIVELEQWKNAKSLKIE---G 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 115534077  203 FDTSSVSIESFFHCKWFSITVLTISAQDARKIEEILLKNEHFTGCDI--KCWTLPVMTEIFQ 262
Cdd:pfam01827  78 SSLSSFPIEHLFHFEEFDIKLDSFSVEDAIKIRDILLKSSTFQSCTIrsPDLNPIEIAKVFD 139
F-box_CeFBXA-like cd22150
F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and ...
 1-39 1.74e-09

F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and similar proteins; The family includes a group of uncharacterized Caenorhabditis elegans F-box domain-containing proteins. They may be components of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438921  Cd Length: 46  Bit Score: 52.49  E-value: 1.74e-09
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 115534077   1 MPIEIIHETLQKMEPRNRLTLRKVSRNLRLAVDHHGIGF 39
Cdd:cd22150    4 LPIEILNKILDKLDPIDRLVLRKVSRNLRDIVDNQDPGF 42
FBOX smart00256
A Receptor for Ubiquitination Targets;
1-39 2.77e-07

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 46.28  E-value: 2.77e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 115534077     1 MPIEIIHETLQKMEPRNRLTLRKVSRNLRLAVDHHGIGF 39
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWF 39
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 1-39 3.91e-04

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 37.52  E-value: 3.91e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 115534077    1 MPIEIIHETLQKMEPRNRLTLRKVSRNLRLAVDHHGIGF 39
Cdd:pfam00646   4 LPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWK 42
 
Name Accession Description Interval E-value
FTH pfam01827
FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is ...
 123-262 8.37e-37

FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is found in many proteins from C. elegans. The domain is found associated with the F-box pfam00646. This domain is named FTH after FOG-2 homology domain.


Pssm-ID: 396410  Cd Length: 141  Bit Score: 128.08  E-value: 8.37e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115534077  123 KNFDALTDRLQAVKPLDVECLLLTDLSLAQCAHLLPFFEAGKLERIAINNdEEEFNKFEEITVLEQWKKAKRLHLNpykG 202
Cdd:pfam01827   2 KIIESFLNILKSKKCLHVKEISLSGLSFSEVASILPYFDAGTLEEIELSS-ESDEDQFEEIVELEQWKNAKSLKIE---G 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 115534077  203 FDTSSVSIESFFHCKWFSITVLTISAQDARKIEEILLKNEHFTGCDI--KCWTLPVMTEIFQ 262
Cdd:pfam01827  78 SSLSSFPIEHLFHFEEFDIKLDSFSVEDAIKIRDILLKSSTFQSCTIrsPDLNPIEIAKVFD 139
F-box_CeFBXA-like cd22150
F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and ...
 1-39 1.74e-09

F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and similar proteins; The family includes a group of uncharacterized Caenorhabditis elegans F-box domain-containing proteins. They may be components of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438921  Cd Length: 46  Bit Score: 52.49  E-value: 1.74e-09
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 115534077   1 MPIEIIHETLQKMEPRNRLTLRKVSRNLRLAVDHHGIGF 39
Cdd:cd22150    4 LPIEILNKILDKLDPIDRLVLRKVSRNLRDIVDNQDPGF 42
FBOX smart00256
A Receptor for Ubiquitination Targets;
1-39 2.77e-07

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 46.28  E-value: 2.77e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 115534077     1 MPIEIIHETLQKMEPRNRLTLRKVSRNLRLAVDHHGIGF 39
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWF 39
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 1-39 3.91e-04

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 37.52  E-value: 3.91e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 115534077    1 MPIEIIHETLQKMEPRNRLTLRKVSRNLRLAVDHHGIGF 39
Cdd:pfam00646   4 LPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWK 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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