NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|17538616|ref|NP_501542|]
View 

CCCH-type zinc finger protein oma-1 [Caenorhabditis elegans]

Protein Classification

CTH1 family zinc finger protein( domain architecture ID 1004917)

CTH1 family zinc finger protein similar to Homo sapiens mRNA decay activator protein ZFP36 that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis

CATH:  4.10.1000.10
Gene Ontology:  GO:0046872|GO:0003676
PubMed:  12665246|11179890
SCOP:  4003893

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
CTH1 super family cl34885
CCCH-type Zn-finger protein [General function prediction only];
94-179 1.20e-07

CCCH-type Zn-finger protein [General function prediction only];


The actual alignment was detected with superfamily member COG5063:

Pssm-ID: 227395 [Multi-domain]  Cd Length: 351  Bit Score: 53.13  E-value: 1.20e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538616  94 FQQFDPRRRGLARMqKPES----YKTVICQAWLESKTCSFADNCRFAHGEEELRPTFVEPlqNNKYKTKLCDKYTTTGLC 169
Cdd:COG5063 250 KCQFACRGHGLNEL-KSKKkkqnFRTEPCINWEKSGYCPYGLRCCFKHGDDSDIEMYEEA--SLGYLDGPCRTRAKGGAF 326

                        90
                ....*....|
gi 17538616 170 PYGKRCLFIH 179
Cdd:COG5063 327 PSGGAVCKSF 336
 
Name Accession Description Interval E-value
CTH1 COG5063
CCCH-type Zn-finger protein [General function prediction only];
94-179 1.20e-07

CCCH-type Zn-finger protein [General function prediction only];


Pssm-ID: 227395 [Multi-domain]  Cd Length: 351  Bit Score: 53.13  E-value: 1.20e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538616  94 FQQFDPRRRGLARMqKPES----YKTVICQAWLESKTCSFADNCRFAHGEEELRPTFVEPlqNNKYKTKLCDKYTTTGLC 169
Cdd:COG5063 250 KCQFACRGHGLNEL-KSKKkkqnFRTEPCINWEKSGYCPYGLRCCFKHGDDSDIEMYEEA--SLGYLDGPCRTRAKGGAF 326

                        90
                ....*....|
gi 17538616 170 PYGKRCLFIH 179
Cdd:COG5063 327 PSGGAVCKSF 336
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
155-181 2.32e-07

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 46.42  E-value: 2.32e-07
                          10        20
                  ....*....|....*....|....*..
gi 17538616   155 YKTKLCDKYTTTGLCPYGKRCLFIHPD 181
Cdd:pfam00642   1 YKTELCRFFLRTGYCKYGDRCKFAHGQ 27
ZnF_C3H1 smart00356
zinc finger;
154-181 1.02e-06

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 44.54  E-value: 1.02e-06
                           10        20
                   ....*....|....*....|....*...
gi 17538616    154 KYKTKLCDKYTTtGLCPYGKRCLFIHPD 181
Cdd:smart00356   1 KYKTELCKFFKR-GYCPRGDRCKFAHPL 27
 
Name Accession Description Interval E-value
CTH1 COG5063
CCCH-type Zn-finger protein [General function prediction only];
94-179 1.20e-07

CCCH-type Zn-finger protein [General function prediction only];


Pssm-ID: 227395 [Multi-domain]  Cd Length: 351  Bit Score: 53.13  E-value: 1.20e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538616  94 FQQFDPRRRGLARMqKPES----YKTVICQAWLESKTCSFADNCRFAHGEEELRPTFVEPlqNNKYKTKLCDKYTTTGLC 169
Cdd:COG5063 250 KCQFACRGHGLNEL-KSKKkkqnFRTEPCINWEKSGYCPYGLRCCFKHGDDSDIEMYEEA--SLGYLDGPCRTRAKGGAF 326

                        90
                ....*....|
gi 17538616 170 PYGKRCLFIH 179
Cdd:COG5063 327 PSGGAVCKSF 336
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
155-181 2.32e-07

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 46.42  E-value: 2.32e-07
                          10        20
                  ....*....|....*....|....*..
gi 17538616   155 YKTKLCDKYTTTGLCPYGKRCLFIHPD 181
Cdd:pfam00642   1 YKTELCRFFLRTGYCKYGDRCKFAHGQ 27
ZnF_C3H1 smart00356
zinc finger;
154-181 1.02e-06

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 44.54  E-value: 1.02e-06
                           10        20
                   ....*....|....*....|....*...
gi 17538616    154 KYKTKLCDKYTTtGLCPYGKRCLFIHPD 181
Cdd:smart00356   1 KYKTELCKFFKR-GYCPRGDRCKFAHPL 27
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
113-139 1.41e-06

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 44.49  E-value: 1.41e-06
                          10        20
                  ....*....|....*....|....*..
gi 17538616   113 YKTVICQAWLESKTCSFADNCRFAHGE 139
Cdd:pfam00642   1 YKTELCRFFLRTGYCKYGDRCKFAHGQ 27
CTH1 COG5063
CCCH-type Zn-finger protein [General function prediction only];
108-179 7.03e-06

CCCH-type Zn-finger protein [General function prediction only];


Pssm-ID: 227395 [Multi-domain]  Cd Length: 351  Bit Score: 47.74  E-value: 7.03e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17538616 108 QKPESYKTVICQAWLESKTCSFADNCRFAHGEEELRPTFVEPlqnnKYKTKLCDKYTTTGLCPYGKRCLFIH 179
Cdd:COG5063 108 KPYGLYKTEMLRSSTEIPYCRYPDKNPFAHSKAISSLAQTHP----KYKTESLEVFINPGYVPYSKRCCFIS 175
ZnF_C3H1 smart00356
zinc finger;
112-139 1.93e-04

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 38.38  E-value: 1.93e-04
                           10        20
                   ....*....|....*....|....*...
gi 17538616    112 SYKTVICQAWlESKTCSFADNCRFAHGE 139
Cdd:smart00356   1 KYKTELCKFF-KRGYCPRGDRCKFAHPL 27
CTH1 COG5063
CCCH-type Zn-finger protein [General function prediction only];
118-181 3.22e-04

CCCH-type Zn-finger protein [General function prediction only];


Pssm-ID: 227395 [Multi-domain]  Cd Length: 351  Bit Score: 42.35  E-value: 3.22e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17538616 118 CQAWLESKTCSFAdnCRfAHGEEELRPtfvEPLQNNkYKTKLCDKYTTTGLCPYGKRCLFIHPD 181
Cdd:COG5063 242 CPYWISGVKCQFA--CR-GHGLNELKS---KKKKQN-FRTEPCINWEKSGYCPYGLRCCFKHGD 298
zf_CCCH_4 pfam18345
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ...
 118-137 9.07e-03

Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.


Pssm-ID: 465719 [Multi-domain]  Cd Length: 19  Bit Score: 33.54  E-value: 9.07e-03
                          10        20
                  ....*....|....*....|
gi 17538616   118 CQAWLEsKTCSFADNCRFAH 137
Cdd:pfam18345   1 CKFFLK-GRCRYGDKCRFAH 19
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH