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Conserved domains on  [gi|17542642|ref|NP_501853|]
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Tetraspanin-12 [Caenorhabditis elegans]

Protein Classification

tetraspanin family protein( domain architecture ID 11992924)

tetraspanin family protein is a transmembrane (TM) glycoprotein with four TM segments that facilitates the interaction of membrane and intracellular signaling molecules (such as integrins, pro-growth factors and their receptors, protein kinase-C) in the formation of membrane signaling microdomains (also referred to as the tetraspanin web)

CATH:  1.10.1450.10
Gene Ontology:  GO:0016020
PubMed:  11756464|19709882|16024509|12575999
SCOP:  4001512
TCDB:  8.A.40

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
tetraspanin_LEL super family cl02781
Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are ...
 133-268 1.86e-31

Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. The tetraspanin family contains CD9, CD63, CD37, CD53, CD82, CD151, and CD81, amongst others. Tetraspanins are involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, cancer, and others. Their various functions may relate to their ability to act as molecular facilitators, grouping specific cell-surface proteins and affecting formation and stability of signaling complexes. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web", which may also include integrins.


The actual alignment was detected with superfamily member cd03159:

Pssm-ID: 351888 [Multi-domain]  Cd Length: 121  Bit Score: 114.06  E-value: 1.86e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542642 133 VFAYACRDQLdnyiRNLLNDVVVGYRDDPDLQLLIDSMQETWMCCGINGADDWDRNTYFSIeAREVASPEAGGVPFSCCI 212
Cdd:cd03159   2 VFKDWIKDQL----TEFLNNNIRAYRDDIDLQNLIDFLQEYWQCCGARGPDDWNLNIYFNC-TDSNPSRERCGVPFSCCV 76

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 17542642 213 NSSKLEFKNYFCGHGVRLKPESHMAAHlaaqrvmahtasIYTEGCLPKLQLWLNNN 268
Cdd:cd03159  77 KDPAEDVVNTQCGYDVRKKPELELQHH------------IHTKGCVQAFEKWLQDN 120
Tetraspanin pfam00335
Tetraspanin family;
38-293 1.61e-25

Tetraspanin family;


:

Pssm-ID: 459767  Cd Length: 183  Bit Score: 100.09  E-value: 1.61e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542642    38 VKYSVFSFNVIFFLLGFGLLLFGVWAQIEKNTFVNMLSKASKLYLdptWPLLIVGFLTFIIGFSGCVGSLRENTSFLTFY 117
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVGVWLLSAFSLLLLGLSEASAYIP---ILLIVLGAVIFLVGFLGCCGALKENRCLLLTY 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542642   118 STLLGLLLIAEFSAGVFAYACRDQLDNYIRNLLND-VVVGYRDDPDLQL----LIDSMQETWMCCGingaddwdrntyfs 192
Cdd:pfam00335  78 FVLLLLLFLAELAAGILAFVYRDKLSGLLSNWLKKsLEDGYRDWLDLYSclnsALDSLQSEFGCCG-------------- 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542642   193 iearevaspeaggvpfsccinssklefknyfcghgvrlkpeshmaahlaaqrvmahtasiyteGCLPKLQLWLNNNMLLV 272
Cdd:pfam00335 144 ---------------------------------------------------------------GCKEKLLEWLRKNLKII 160

                         250       260
                  ....*....|....*....|.
gi 17542642   273 AVSMVIIAIIQVLGICFAQNL 293
Cdd:pfam00335 161 GAGVIALGVIQLLGIILACCL 181
 
Name Accession Description Interval E-value
TM4SF9_like_LEL cd03159
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. ...
 133-268 1.86e-31

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 9 (TM4SF9) or Tetraspanin-5 and related proteins. TM4SF9 is strongly expressed witin the central nervous system, and expression levels appear to correlate with differentiation status of particular neurons, hinting at a role in neuronal maturation.


Pssm-ID: 239412 [Multi-domain]  Cd Length: 121  Bit Score: 114.06  E-value: 1.86e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542642 133 VFAYACRDQLdnyiRNLLNDVVVGYRDDPDLQLLIDSMQETWMCCGINGADDWDRNTYFSIeAREVASPEAGGVPFSCCI 212
Cdd:cd03159   2 VFKDWIKDQL----TEFLNNNIRAYRDDIDLQNLIDFLQEYWQCCGARGPDDWNLNIYFNC-TDSNPSRERCGVPFSCCV 76

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 17542642 213 NSSKLEFKNYFCGHGVRLKPESHMAAHlaaqrvmahtasIYTEGCLPKLQLWLNNN 268
Cdd:cd03159  77 KDPAEDVVNTQCGYDVRKKPELELQHH------------IHTKGCVQAFEKWLQDN 120
Tetraspanin pfam00335
Tetraspanin family;
38-293 1.61e-25

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 100.09  E-value: 1.61e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542642    38 VKYSVFSFNVIFFLLGFGLLLFGVWAQIEKNTFVNMLSKASKLYLdptWPLLIVGFLTFIIGFSGCVGSLRENTSFLTFY 117
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVGVWLLSAFSLLLLGLSEASAYIP---ILLIVLGAVIFLVGFLGCCGALKENRCLLLTY 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542642   118 STLLGLLLIAEFSAGVFAYACRDQLDNYIRNLLND-VVVGYRDDPDLQL----LIDSMQETWMCCGingaddwdrntyfs 192
Cdd:pfam00335  78 FVLLLLLFLAELAAGILAFVYRDKLSGLLSNWLKKsLEDGYRDWLDLYSclnsALDSLQSEFGCCG-------------- 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542642   193 iearevaspeaggvpfsccinssklefknyfcghgvrlkpeshmaahlaaqrvmahtasiyteGCLPKLQLWLNNNMLLV 272
Cdd:pfam00335 144 ---------------------------------------------------------------GCKEKLLEWLRKNLKII 160

                         250       260
                  ....*....|....*....|.
gi 17542642   273 AVSMVIIAIIQVLGICFAQNL 293
Cdd:pfam00335 161 GAGVIALGVIQLLGIILACCL 181
 
Name Accession Description Interval E-value
TM4SF9_like_LEL cd03159
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. ...
 133-268 1.86e-31

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 9 (TM4SF9) or Tetraspanin-5 and related proteins. TM4SF9 is strongly expressed witin the central nervous system, and expression levels appear to correlate with differentiation status of particular neurons, hinting at a role in neuronal maturation.


Pssm-ID: 239412 [Multi-domain]  Cd Length: 121  Bit Score: 114.06  E-value: 1.86e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542642 133 VFAYACRDQLdnyiRNLLNDVVVGYRDDPDLQLLIDSMQETWMCCGINGADDWDRNTYFSIeAREVASPEAGGVPFSCCI 212
Cdd:cd03159   2 VFKDWIKDQL----TEFLNNNIRAYRDDIDLQNLIDFLQEYWQCCGARGPDDWNLNIYFNC-TDSNPSRERCGVPFSCCV 76

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 17542642 213 NSSKLEFKNYFCGHGVRLKPESHMAAHlaaqrvmahtasIYTEGCLPKLQLWLNNN 268
Cdd:cd03159  77 KDPAEDVVNTQCGYDVRKKPELELQHH------------IHTKGCVQAFEKWLQDN 120
penumbra_like_LEL cd03158
Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. ...
 133-269 4.09e-27

Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Human Penumbra exhibits growth-suppressive activity in vitro and has been associated with myeloid malignancies.


Pssm-ID: 239411  Cd Length: 119  Bit Score: 102.38  E-value: 4.09e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542642 133 VFAYACRDQLDNYIRNllndVVVGYRDDPDLQLLIDSMQETWMCCGINGADDWDRNTYFSIEArevASPEAGGVPFSCCI 212
Cdd:cd03158   2 IFSNQTIDLLEENIRK----AIVHYYDDLDLQNIIDFVQKEFKCCGGDDYRDWSKNMYFNCSS---PNPEACGVPYSCCI 74

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 17542642 213 NSSKLEFKNYFCGHGVRLKPeshmaaHLAAQRVmahtasIYTEGCLPKLQLWLNNNM 269
Cdd:cd03158  75 RAKDQEVINTMCGYGVQNLE------RLEASKL------IYTRGCIDAVVLWIEDNL 119
Tetraspanin pfam00335
Tetraspanin family;
38-293 1.61e-25

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 100.09  E-value: 1.61e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542642    38 VKYSVFSFNVIFFLLGFGLLLFGVWAQIEKNTFVNMLSKASKLYLdptWPLLIVGFLTFIIGFSGCVGSLRENTSFLTFY 117
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVGVWLLSAFSLLLLGLSEASAYIP---ILLIVLGAVIFLVGFLGCCGALKENRCLLLTY 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542642   118 STLLGLLLIAEFSAGVFAYACRDQLDNYIRNLLND-VVVGYRDDPDLQL----LIDSMQETWMCCGingaddwdrntyfs 192
Cdd:pfam00335  78 FVLLLLLFLAELAAGILAFVYRDKLSGLLSNWLKKsLEDGYRDWLDLYSclnsALDSLQSEFGCCG-------------- 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542642   193 iearevaspeaggvpfsccinssklefknyfcghgvrlkpeshmaahlaaqrvmahtasiyteGCLPKLQLWLNNNMLLV 272
Cdd:pfam00335 144 ---------------------------------------------------------------GCKEKLLEWLRKNLKII 160

                         250       260
                  ....*....|....*....|.
gi 17542642   273 AVSMVIIAIIQVLGICFAQNL 293
Cdd:pfam00335 161 GAGVIALGVIQLLGIILACCL 181
tetraspanin_LEL cd03127
Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are ...
 136-269 1.27e-19

Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. The tetraspanin family contains CD9, CD63, CD37, CD53, CD82, CD151, and CD81, amongst others. Tetraspanins are involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, cancer, and others. Their various functions may relate to their ability to act as molecular facilitators, grouping specific cell-surface proteins and affecting formation and stability of signaling complexes. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web", which may also include integrins.


Pssm-ID: 239401 [Multi-domain]  Cd Length: 90  Bit Score: 81.78  E-value: 1.27e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542642 136 YACRDQLDNYIRNLLNDVVVGYRDDPDLQLLIDSMQETWMCCGINGADDWDRNtyfsiearevaspeAGGVPFSCCINSS 215
Cdd:cd03127   1 FVYRDQLESLVSDTLNDAWDEYYVDDDFQEAMDALQSTFECCGVNGPTDYLDL--------------RLLVPSSCCKGTD 66

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 17542642 216 klefknyfcghgvrlkpeshmaahlaaqrvMAHTASIYTEGCLPKLQLWLNNNM 269
Cdd:cd03127  67 ------------------------------GNCGLNLYTEGCLEKLVDFLRSNL 90
oculospanin_like_LEL cd03167
Tetraspanin, extracellular domain or large extracellular loop (LEL), oculospanin_like family. ...
 137-268 8.17e-18

Tetraspanin, extracellular domain or large extracellular loop (LEL), oculospanin_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contains sequences similar to oculospanin, which is found to be expressed in retinal pigment epithelium, iris, ciliary body, and retinal ganglion cells.


Pssm-ID: 239420  Cd Length: 120  Bit Score: 77.89  E-value: 8.17e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542642 137 ACRDQLDNYIRNLLNDVVVGYRDDPDLQLLIDSMQETWMCCGINGADDWDRNTYFSIEAREVaspEAGGVPFSCCINSSK 216
Cdd:cd03167   2 ALWGPLQDGLEHTLRLAIAHYQDDPDLRFLIDQVQLGLQCCGASSYQDWQQNLYFNCSSPGV---QACSLPASCCIDPRE 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 17542642 217 L-EFKNYFCGHGVRLKPEShmaahlAAQRVmahtasIYTEGCLPKLQLWLNNN 268
Cdd:cd03167  79 DgAVVNDQCGFGALGLDED------AAQRV------VHLGGCGPPLRRWLRGN 119
CD63_LEL cd03166
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins ...
 136-268 1.63e-12

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD63 is present in platelets, neutrophils, and endothelial cells, amongst others. In platelets it associates with the integrin alphaIIBbeta3 and may modulate alphaIIbbeta3-dependent cytoskeletal reorganization.


Pssm-ID: 239419  Cd Length: 99  Bit Score: 62.49  E-value: 1.63e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542642 136 YACRDQLDNYIRNLLNDVVVGYRDDPDLQLLIDSMQETWMCCGINGADDWdRNTYFSIEARevaspeaggVPFSCCINSS 215
Cdd:cd03166   1 YVFRDKVMSEFNDSFNQMISNYNKTNDFRKILDRMQKDLKCCGANNYTDW-ENIPSLDTDS---------VPDSCCINVT 70

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 17542642 216 KlefknyFCGHGvrlkpeshmaahlaaqrvmAHTASIYTEGCLPKLQLWLNNN 268
Cdd:cd03166  71 K------GCGIN-------------------FDEKVIHLEGCVTKIEGWLKKN 98
CD53_like_LEL cd03164
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD53_Like family. ...
 141-270 6.88e-12

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD53_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD53 is a tetraspanin of the lymphoid-myeloid lineage and has been implicated in apoptosis protection. It associates with integrin alpha4beta1. Some of the cellular responses modulated by CD53 may be mediated by JNK activation and/or via the AKT pathway.


Pssm-ID: 239417 [Multi-domain]  Cd Length: 86  Bit Score: 60.57  E-value: 6.88e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542642 141 QLDNYIRNLLNDVVVGYRDDPDLQLLIDSMQETWMCCGINGADDWdrntyfsiearevaspeAGGVPFSCCINSSklefk 220
Cdd:cd03164   6 KLNNYVKEGLTDSLEQYHKDNNTSEAWDMIQSNLQCCGINGTTDW-----------------GSGVPSSCCSSDT----- 63

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 17542642 221 nyfcghgvrlkpeshmaahlaaqrvmahtaSIYTEGCLPKLQLWLNNNML 270
Cdd:cd03164  64 ------------------------------EYKVEGCYKKLKNWFESNFL 83
uroplakin_I_like_LEL cd03156
Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. ...
 140-269 1.44e-10

Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Uroplakin Ia and Ib are components of the 16nm protein particles, which are packed hexagonally to form 2D crystals of asymmetric unit membranes, and cover the apical surface of mammalian urothelium, contributing to the urinay bladder's permeability barrier function. Uroplakins Ia and Ib are maturation facilitators. They trigger conformational changes in their single-transmembrane-domain binding partner proteins uroplakin II and IIIa, which in turn may lead to ER-exit, stabilization, and cell-surface expression.


Pssm-ID: 239409  Cd Length: 114  Bit Score: 57.54  E-value: 1.44e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542642 140 DQLDNYIRNLL-NDVVVGYRDDPDLQLLIDSMQETWMCCGINGADDWDRNTYFSIEAREVASPeaggVPFSCCINSSKLE 218
Cdd:cd03156   7 KDLEDSFKNLLkNNYGNYNSTGDAITSTWNRVMIELKCCGVNGPTDFVDSTSFFRQKNEPNSP----YPESCCKRNSNSQ 82

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 17542642 219 FKNYFCghgvrlkpeshmaahlaaqRVMAHTASIYTEGCLPKLQLWLNNNM 269
Cdd:cd03156  83 IVDLDC-------------------PKLGSPNSYNKKGCYEKLSNPIERYA 114
CD37_CD82_like_LEL cd03160
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. ...
 136-268 9.16e-10

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD37 is a leukocyte-specific protein, and its restricted expression pattern suggests a role in the immune system. A regulatory role in T-cell proliferation has been suggested. CD82 is a metastasis suppressor implicated in biological processes ranging from fusion, adhesion, and migration to apoptosis and alterations of cell morphology.


Pssm-ID: 239413  Cd Length: 117  Bit Score: 55.47  E-value: 9.16e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542642 136 YACRDQLDNYIRNLLNDVVVGYRDDPD---LQLLIDSMQETWMCCGINGADDWDRNTyfsiearEVASPEAGGVPFSCCI 212
Cdd:cd03160   2 YFQRDKLKQEMGDIVEKVIQNYGGNPEnktAEEAWDYVQFQLQCCGWTGPQDWTDNS-------LIKNSSEPLYPCSCCN 74

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 17542642 213 NS---SKLEFKNYFCGHGVRLKpeshmaahlaaqrvmahtASIYTEGCLPKLQLWLNNN 268
Cdd:cd03160  75 SSataDSPRPSKGFCEAPASLD------------------WPVYQEGCMEKLQSWLNEN 115
TM4SF2_6_like_LEL cd03161
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. ...
 136-269 2.77e-09

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 2 (TM4SF2) or Tspan-7, transmembrane 4 superfamily 6 (TM4SF6) or Tspan-6, and related proteins. TM4SF2 has been identified as involved in some forms of X-linked mental retardation.


Pssm-ID: 239414  Cd Length: 104  Bit Score: 53.90  E-value: 2.77e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542642 136 YACRDQLDNYIRNLLNDVVVGYRDDPDLQLLIDSMQETWMCCGINGADDWDRNTYFSIEarevaspeagGVPFSCCINSS 215
Cdd:cd03161   1 FVFRHEIKGTFLRTYNEAVSNYNGDDERSDAVDTVQRTLHCCGVENYTDWLNSPYFLEK----------GIPLSCCKNRS 70

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 17542642 216 KlefknyfCghgvrlKPESHMAAHLAAQRVmahtasiYTEGCLPKLQLWLNNNM 269
Cdd:cd03161  71 D-------C------SPQDLKNLTKAATKV-------YQQGCFTLVTSFMEANM 104
NET-5_like_LEL cd03165
Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. ...
 136-268 1.05e-07

Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This sub-family contains proteins similar to human tetraspan NET-5.


Pssm-ID: 239418 [Multi-domain]  Cd Length: 98  Bit Score: 49.29  E-value: 1.05e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542642 136 YACRDQLDNYIRNLLNDVVVGY--RDDPDLQLLIDSMQETWMCCGINGADDWDRntyFSIEARevaspeaggVPFSCCIN 213
Cdd:cd03165   1 FVFREKVDLTAKDDLKEGLELYgtRNNRGLTNAWDITQTEFRCCGVTNYTDWYE---VLGENR---------VPDSCCQE 68

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 17542642 214 SSKlefknyFCGHGvrlkpeshmaahlaaqrvmaHTASIYTEGCLPKLQLWLNNN 268
Cdd:cd03165  69 DSQ------DCGRN--------------------PTELWWKTGCYEKVQQWLVDN 97
CD151_like_LEL cd03155
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. ...
 136-268 1.15e-07

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD151strongly associates with integrins, especially alpha3beta1, alpha6beta1, alpha7beta1, and alpha6beta4; it may play roles in cell-cell adhesion, cell migration, platelet aggregation, and angiogenesis. For example, CD151 is is involved in regulation of migration of neutrophils, endothelial cells, and various tumor cell lines; it associates specifically with laminin-binding integrins and strengthens alpha6beta1 integrin-mediated adhesion to laminin-1; CD151 also specifically attenuates adhesion-dependent activation of Ras and correspdonding downstream effects, and is involved in epithelial cell-cell adhesion as a modulator of PKC- and Cdc42-dependent actin cytoskeletal reorganization.


Pssm-ID: 239408 [Multi-domain]  Cd Length: 110  Bit Score: 49.27  E-value: 1.15e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542642 136 YACRDQLDNYIR-NLLNDVVVGYRDD--PDLQLLIDSMQETWMCCGINGADDWDRNTYFSiearevaSPEAGG--VPFSC 210
Cdd:cd03155   1 YTYYQQLEDELKeSLKRTMQENYGQSgeEALTLTVDELQQEFKCCGSNNYTDWQDSEWIN-------SNEANGrlVPDSC 73

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542642 211 CINSSKLEFKnyfcghgvrlkpeshmaahlaaQRVmaHTASIY--TEGCLPKLQLWLNNN 268
Cdd:cd03155  74 CKTVVDRCGC----------------------LRD--HPSNIYkvEGGCIPKLEDFLYDH 109
TM4SF8_like_LEL cd03163
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF8_like subfamily. ...
 135-261 6.91e-06

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF8_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 8 (TM4SF8) or Tspan-3 and related proteins. Tspan-3 has been reported to form a complex with integrin beta1 and OSP/claudin-11, which may be involved in oligodendrocyte proliferation and migration.


Pssm-ID: 239416  Cd Length: 105  Bit Score: 44.34  E-value: 6.91e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542642 135 AYACRDQLDNYIRNLLNDVVVGYRDDPDLQLLIDSMQETWMCCGINGADDWDRNTYFSiearevaSPEAGGVPFSCCins 214
Cdd:cd03163   1 GYVYRAKVEDELNPSIDKVFNKYNGTNAESRAVDYLQRQLQCCGIHNYTDWENTPWFK-------ESKNNSVPLSCC--- 70

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 17542642 215 sklefKNYFCGhgvrlkpeshmaahlaAQRVMAHTASIYTEGCLPKL 261
Cdd:cd03163  71 -----KETFTS----------------CTGSLTQPKDLYQEGCEAKL 96
peripherin_like_LEL cd03162
Tetraspanin, extracellular domain or large extracellular loop (LEL), peripherin_like family. ...
 136-215 8.62e-06

Tetraspanin, extracellular domain or large extracellular loop (LEL), peripherin_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Peripherin, or RDS (retinal degradation slow) is a glycoprotein expressed in vertebrate photoreceptors, located at the rim of the disc membranes of the photoreceptor outer segments. RDS is thought to play a major role in folding and stacking of the discs. Mutations in RDS have been linked to hereditary retinal dystrophies, which typically exhibit a wide phenotypic spectrum.


Pssm-ID: 239415  Cd Length: 143  Bit Score: 44.73  E-value: 8.62e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542642 136 YACRDQLDNYIRNLLNDVVVGYRDDPD-----LQLLIDSMQETWMCCGINGADDWDR-----NTYFSIEAREVASPEAG- 204
Cdd:cd03162   1 FIMRGSLEESLKTGLKNAMKFYKDTDTpgrcfLKKTIDMLQIEFQCCGNNGYRDWFEiqwisNRYLDFSSKEVKDRIKSn 80

                        90
                ....*....|....*....
gi 17542642 205 --------GVPFSCCINSS 215
Cdd:cd03162  81 vdgryltdGVPFSCCNPSS 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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