NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|17563562|ref|NP_504023|]
View 

G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

Protein Classification

class R serpentine receptor( domain architecture ID 10563422)

class R serpentine receptor, also known as seven TM receptor (Str), belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 10-313 5.14e-96

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402099  Cd Length: 307  Bit Score: 287.43  E-value: 5.14e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563562    10 TEVCSFVGFMLSVLGNSTLLVLLSGKSIDGIGTYRYLMITFCVFSLLFTILEDFIRPLMHHYNNTIIV-LQRKRFQFSDS 88
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVfVDLKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563562    89 TARILTVSYCGCFAMCFVMFAVHFIYRYLVACHPTKLHYFRPKNFIFWLSGMLFIAGSWVAIAYVFFQEDLETRTDLVFI 168
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563562   169 LSTCYNLTPDDVGHVPYAFYKTQGN-TRVIRWDNMIGVIHHMIVMTISISAVFYFGIKTYTRIMSFKG-KSQKTKDLQNQ 246
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYPTDENgSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSlGSEKTRKLQKQ 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17563562   247 FFTALVAQTVVPLIFMFIPNMVLTTAALIDGTFGSWANITVVMNHLYPAADPFVILFIIKGFRNSIR 313
Cdd:pfam10326 241 LFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 10-313 5.14e-96

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 287.43  E-value: 5.14e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563562    10 TEVCSFVGFMLSVLGNSTLLVLLSGKSIDGIGTYRYLMITFCVFSLLFTILEDFIRPLMHHYNNTIIV-LQRKRFQFSDS 88
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVfVDLKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563562    89 TARILTVSYCGCFAMCFVMFAVHFIYRYLVACHPTKLHYFRPKNFIFWLSGMLFIAGSWVAIAYVFFQEDLETRTDLVFI 168
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563562   169 LSTCYNLTPDDVGHVPYAFYKTQGN-TRVIRWDNMIGVIHHMIVMTISISAVFYFGIKTYTRIMSFKG-KSQKTKDLQNQ 246
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYPTDENgSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSlGSEKTRKLQKQ 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17563562   247 FFTALVAQTVVPLIFMFIPNMVLTTAALIDGTFGSWANITVVMNHLYPAADPFVILFIIKGFRNSIR 313
Cdd:pfam10326 241 LFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 10-313 5.14e-96

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 287.43  E-value: 5.14e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563562    10 TEVCSFVGFMLSVLGNSTLLVLLSGKSIDGIGTYRYLMITFCVFSLLFTILEDFIRPLMHHYNNTIIV-LQRKRFQFSDS 88
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVfVDLKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563562    89 TARILTVSYCGCFAMCFVMFAVHFIYRYLVACHPTKLHYFRPKNFIFWLSGMLFIAGSWVAIAYVFFQEDLETRTDLVFI 168
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563562   169 LSTCYNLTPDDVGHVPYAFYKTQGN-TRVIRWDNMIGVIHHMIVMTISISAVFYFGIKTYTRIMSFKG-KSQKTKDLQNQ 246
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYPTDENgSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSlGSEKTRKLQKQ 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17563562   247 FFTALVAQTVVPLIFMFIPNMVLTTAALIDGTFGSWANITVVMNHLYPAADPFVILFIIKGFRNSIR 313
Cdd:pfam10326 241 LFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 16-312 1.67e-29

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 115.03  E-value: 1.67e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563562    16 VGFMLSVLGNSTLLVLLSGKSIDGIGTYRYLMITFCVFSLLFTILEDFIRPLMHHYNNTIIVLQRKRFQFSDST-ARILT 94
Cdd:pfam10319  13 IFGVLSFIVNPIFIYLIFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVVFVSDGPFFEYSElGQHAL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563562    95 VSYCGCFAMCFVMFAVHFIYRYLVACHPTKL-HYFRPKNFIFWLSGMLFIAGSWVAIAYVFFQEDLETRTDLVFILSTCY 173
Cdd:pfam10319  93 SARCSFISASYAVLLIHFIYRYLVLFNPQLTrHYFRPWGILISILFFLFHGSVWTAICYFLLRANDEIRDYIREDFRETY 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563562   174 NLTPDDVGHVPYAFYKTQGNTRVIRWdnmIGVIHHMIVMTISISAVFYFGIKTYTRIMSFKGK-SQKTKDLQNQFFTALV 252
Cdd:pfam10319 173 GVDSMDINMLGALYWEASDETVFRSW---LGILLLTVISVYSIILYIVLGYKIMRKLNKMSVTmSKKTKRLQKQLLKALI 249

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17563562   253 AQTVVPLIFMFIPNMVLTTAALIDGTFGSWAN-ITVVMNHLYPAADPFVILFIIKGFRNSI 312
Cdd:pfam10319 250 VQTIIPICISFSPCVLAWYSPIFGIDLGRWNNyLEVIALSAFPFIDPLAIILCLPVYRNRI 310
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 18-313 1.65e-08

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 54.86  E-value: 1.65e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563562    18 FMLSVLGNSTLLVLLSGKSIDGIGTYRYLMITFCVFSLLFTILEDFIRPLMHHYNNTIIVLQRK--RFqFSDSTARILTV 95
Cdd:pfam10317   9 FILGLILNLLLLYLIIFKSPKSLKTYRILLLNTAITQIISCILAFFTQQRIIPNGVSMALISYGpcKY-FGPWFCYSGYS 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563562    96 SYCGCFAMCFVMFAVHFIYRYLVACH--PTKLHYFRpknFIFWLSGMLFIagswVAIAYVFFQEDLETRTDLVFILSTCY 173
Cdd:pfam10317  88 LLQHFLLHSGWSLLLTFYYRYYILKHvdPKRKKLIL---LIIIHYIPSLS----QLIVIFLSPTDFLPVEALTKELHPNY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563562   174 NLTPDDVGhvpyafyktqGNTRVIRWDNMIGVIHHMIVMTISISAVFYFGIKTYTRIMSFKGK-SQKTKDLQNQFFTALV 252
Cdd:pfam10317 161 NLTDYTVT----------GFSDLQSFPALINTLIMTIPVFPIPIIILILRRKILKLLNSNSVNmSPTTKAQHRQLIKGLT 230

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17563562   253 AQTVVPLIFmFIPNMVLTTAALIDGTFGSWA-NITVVMNHLYPAADPFVILFIIKGFRNSIR 313
Cdd:pfam10317 231 IQALLPLFS-YIPGVTLYLLSQLTGTEFLILeYFIFVLPALPPLLDPLITIYFVTPYRRAIL 291
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
 97-318 2.25e-08

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 54.86  E-value: 2.25e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563562    97 YCGCFAMCFVMFAV--HFIYRYLVAC---HPTKLHYFRpknfIFWLSGMLFIAGSWVAIAYVFFQEDLETRTdlvFILST 171
Cdd:pfam10318  90 YIGVTSLALVGVSIilLFENRYSILFtnkKRITWKKTR----VLYLIFNYIIALLFLIPIYLNIPDQEAAKL---KVLKK 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563562   172 CYNLTPDDVGHVPYAfyktqgntrVIRWDNMIGVIHHMIVMTISISAVFYFGIKT--YTRIMSFKGKSQKTKDLQNQFFT 249
Cdd:pfam10318 163 LPCLPPEFFDNPPVF---------VLAIDSTYFLICIVLLILILIIQILFFVFLTiyYLFKSVKSSLSKKTRKLQKKFFI 233

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17563562   250 ALVAQTVVPLIFMFIPNMVLTTAALIDGTFGSWANITVVMNHLYPAADPFVILFIIKGFRNSIRNVIYR 318
Cdd:pfam10318 234 ALIIQVSIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFKK 302
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH