NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|17564862|ref|NP_505735|]
View 

F-box domain-containing protein [Caenorhabditis elegans]

Protein Classification

F-box protein( domain architecture ID 10458603)

F-box protein may function as the substrate-recognition component of a SCF(Skp1-cullin-F-box) E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins

CATH:  1.20.1280.50
Gene Ontology:  GO:0005515
PubMed:  31898225|11178263
SCOP:  4001927

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 18-56 3.41e-04

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 425796  Cd Length: 43  Bit Score: 38.29  E-value: 3.41e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 17564862    18 ITELPPKALQQIFATCSATDMTRCSLVNKQFREVIEDME 56
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLK 39
 
Name Accession Description Interval E-value
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 18-56 3.41e-04

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 38.29  E-value: 3.41e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 17564862    18 ITELPPKALQQIFATCSATDMTRCSLVNKQFREVIEDME 56
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLK 39
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 19-53 9.98e-04

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 36.65  E-value: 9.98e-04
                        10        20        30
                ....*....|....*....|....*....|....*
gi 17564862  19 TELPPKALQQIFATCSATDMTRCSLVNKQFREVIE 53
Cdd:cd09917   1 SDLPDEILLKILSYLDPRDLLRLSLVCKRWRELAS 35
FBOX smart00256
A Receptor for Ubiquitination Targets;
21-56 1.67e-03

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 36.26  E-value: 1.67e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 17564862     21 LPPKALQQIFATCSATDMTRCSLVNKQFREVIEDME 56
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHD 36
 
Name Accession Description Interval E-value
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 18-56 3.41e-04

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 38.29  E-value: 3.41e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 17564862    18 ITELPPKALQQIFATCSATDMTRCSLVNKQFREVIEDME 56
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLK 39
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 18-54 9.93e-04

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 37.08  E-value: 9.93e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 17564862    18 ITELPPKALQQIFATCSATDMTRCSLVNKQFREVIED 54
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLLRLALVCRRWRELASD 37
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 19-53 9.98e-04

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 36.65  E-value: 9.98e-04
                        10        20        30
                ....*....|....*....|....*....|....*
gi 17564862  19 TELPPKALQQIFATCSATDMTRCSLVNKQFREVIE 53
Cdd:cd09917   1 SDLPDEILLKILSYLDPRDLLRLSLVCKRWRELAS 35
FBOX smart00256
A Receptor for Ubiquitination Targets;
21-56 1.67e-03

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 36.26  E-value: 1.67e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 17564862     21 LPPKALQQIFATCSATDMTRCSLVNKQFREVIEDME 56
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHD 36
F-box_FBXO31 cd22102
F-box domain found in F-box only protein 31 (FBXO31) and similar proteins; FBXO31, also called ...
 18-52 5.05e-03

F-box domain found in F-box only protein 31 (FBXO31) and similar proteins; FBXO31, also called FBX31, or FBXO14, is a component of an SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. It specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. FBXO31 may act as a tumor suppressor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438874  Cd Length: 48  Bit Score: 35.10  E-value: 5.05e-03
                        10        20        30
                ....*....|....*....|....*....|....*
gi 17564862  18 ITELPPKALQQIFATCSATDMTRCSLVNKQFREVI 52
Cdd:cd22102   1 ILDLPPELLVEIFSSLPGTDLPSLAQVCKKFREIL 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH