Cadherin EGF LAG seven-pass G-type receptor fmi-1 [Caenorhabditis elegans]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | |||||
| Cadherin_repeat | cd11304 | Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ... |
274-371 | 1.26e-37 | |||||
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. : Pssm-ID: 206637 [Multi-domain] Cd Length: 98 Bit Score: 137.06 E-value: 1.26e-37
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| Cadherin_repeat | cd11304 | Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ... |
686-780 | 2.86e-32 | |||||
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. : Pssm-ID: 206637 [Multi-domain] Cd Length: 98 Bit Score: 122.04 E-value: 2.86e-32
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| Cadherin_repeat | cd11304 | Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ... |
486-577 | 4.69e-32 | |||||
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. : Pssm-ID: 206637 [Multi-domain] Cd Length: 98 Bit Score: 121.27 E-value: 4.69e-32
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| Cadherin_repeat | cd11304 | Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ... |
788-888 | 3.72e-31 | |||||
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. : Pssm-ID: 206637 [Multi-domain] Cd Length: 98 Bit Score: 118.57 E-value: 3.72e-31
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| Cadherin_repeat | cd11304 | Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ... |
379-475 | 3.33e-28 | |||||
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. : Pssm-ID: 206637 [Multi-domain] Cd Length: 98 Bit Score: 110.48 E-value: 3.33e-28
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| Cadherin_repeat | cd11304 | Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ... |
896-996 | 2.75e-26 | |||||
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. : Pssm-ID: 206637 [Multi-domain] Cd Length: 98 Bit Score: 104.70 E-value: 2.75e-26
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| LamG | cd00110 | Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ... |
1333-1504 | 3.41e-23 | |||||
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules. : Pssm-ID: 238058 [Multi-domain] Cd Length: 151 Bit Score: 97.87 E-value: 3.41e-23
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| Cadherin_repeat | cd11304 | Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ... |
170-266 | 1.68e-22 | |||||
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. : Pssm-ID: 206637 [Multi-domain] Cd Length: 98 Bit Score: 93.92 E-value: 1.68e-22
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| HormR | smart00008 | Domain present in hormone receptors; |
1917-1974 | 1.00e-12 | |||||
Domain present in hormone receptors; : Pssm-ID: 214468 Cd Length: 70 Bit Score: 65.23 E-value: 1.00e-12
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| GPS | smart00303 | G-protein-coupled receptor proteolytic site domain; Present in latrophilin/CL-1, sea urchin ... |
2170-2218 | 2.07e-11 | |||||
G-protein-coupled receptor proteolytic site domain; Present in latrophilin/CL-1, sea urchin REJ and polycystin. : Pssm-ID: 197639 Cd Length: 49 Bit Score: 60.86 E-value: 2.07e-11
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| EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
1252-1287 | 3.89e-09 | |||||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. : Pssm-ID: 238011 Cd Length: 38 Bit Score: 54.18 E-value: 3.89e-09
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| LamG | cd00110 | Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ... |
1582-1716 | 1.08e-08 | |||||
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules. : Pssm-ID: 238058 [Multi-domain] Cd Length: 151 Bit Score: 56.27 E-value: 1.08e-08
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| 7tm_GPCRs super family | cl28897 | seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ... |
2237-2455 | 1.29e-07 | |||||
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections. The actual alignment was detected with superfamily member cd15040: Pssm-ID: 475119 [Multi-domain] Cd Length: 253 Bit Score: 55.27 E-value: 1.29e-07
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| EGF_Lam | cd00055 | Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
1865-1911 | 9.46e-06 | |||||
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies : Pssm-ID: 238012 Cd Length: 50 Bit Score: 44.65 E-value: 9.46e-06
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| EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
1774-1808 | 2.06e-05 | |||||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. : Pssm-ID: 238011 Cd Length: 38 Bit Score: 43.39 E-value: 2.06e-05
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| Name | Accession | Description | Interval | E-value | |||||
| Cadherin_repeat | cd11304 | Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ... |
274-371 | 1.26e-37 | |||||
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. Pssm-ID: 206637 [Multi-domain] Cd Length: 98 Bit Score: 137.06 E-value: 1.26e-37
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| Cadherin_repeat | cd11304 | Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ... |
686-780 | 2.86e-32 | |||||
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. Pssm-ID: 206637 [Multi-domain] Cd Length: 98 Bit Score: 122.04 E-value: 2.86e-32
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| Cadherin_repeat | cd11304 | Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ... |
486-577 | 4.69e-32 | |||||
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. Pssm-ID: 206637 [Multi-domain] Cd Length: 98 Bit Score: 121.27 E-value: 4.69e-32
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| Cadherin_repeat | cd11304 | Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ... |
788-888 | 3.72e-31 | |||||
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. Pssm-ID: 206637 [Multi-domain] Cd Length: 98 Bit Score: 118.57 E-value: 3.72e-31
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| Cadherin_repeat | cd11304 | Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ... |
379-475 | 3.33e-28 | |||||
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. Pssm-ID: 206637 [Multi-domain] Cd Length: 98 Bit Score: 110.48 E-value: 3.33e-28
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| CA | smart00112 | Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ... |
294-373 | 1.70e-27 | |||||
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium. Pssm-ID: 214520 [Multi-domain] Cd Length: 81 Bit Score: 107.82 E-value: 1.70e-27
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| Cadherin_repeat | cd11304 | Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ... |
896-996 | 2.75e-26 | |||||
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. Pssm-ID: 206637 [Multi-domain] Cd Length: 98 Bit Score: 104.70 E-value: 2.75e-26
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| CA | smart00112 | Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ... |
503-579 | 2.90e-26 | |||||
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium. Pssm-ID: 214520 [Multi-domain] Cd Length: 81 Bit Score: 104.35 E-value: 2.90e-26
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| Cadherin | pfam00028 | Cadherin domain; |
275-365 | 1.41e-24 | |||||
Cadherin domain; Pssm-ID: 394985 [Multi-domain] Cd Length: 92 Bit Score: 99.68 E-value: 1.41e-24
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| CA | smart00112 | Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ... |
705-782 | 6.05e-24 | |||||
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium. Pssm-ID: 214520 [Multi-domain] Cd Length: 81 Bit Score: 97.42 E-value: 6.05e-24
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| Cadherin | pfam00028 | Cadherin domain; |
687-774 | 2.17e-23 | |||||
Cadherin domain; Pssm-ID: 394985 [Multi-domain] Cd Length: 92 Bit Score: 96.22 E-value: 2.17e-23
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| LamG | cd00110 | Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ... |
1333-1504 | 3.41e-23 | |||||
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules. Pssm-ID: 238058 [Multi-domain] Cd Length: 151 Bit Score: 97.87 E-value: 3.41e-23
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| LamG | smart00282 | Laminin G domain; |
1354-1506 | 6.20e-23 | |||||
Laminin G domain; Pssm-ID: 214598 [Multi-domain] Cd Length: 132 Bit Score: 96.64 E-value: 6.20e-23
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| Cadherin_repeat | cd11304 | Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ... |
170-266 | 1.68e-22 | |||||
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. Pssm-ID: 206637 [Multi-domain] Cd Length: 98 Bit Score: 93.92 E-value: 1.68e-22
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| CA | smart00112 | Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ... |
807-890 | 2.62e-21 | |||||
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium. Pssm-ID: 214520 [Multi-domain] Cd Length: 81 Bit Score: 90.10 E-value: 2.62e-21
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| Cadherin | pfam00028 | Cadherin domain; |
486-571 | 3.24e-21 | |||||
Cadherin domain; Pssm-ID: 394985 [Multi-domain] Cd Length: 92 Bit Score: 90.05 E-value: 3.24e-21
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| CA | smart00112 | Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ... |
398-477 | 4.00e-20 | |||||
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium. Pssm-ID: 214520 [Multi-domain] Cd Length: 81 Bit Score: 86.63 E-value: 4.00e-20
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| Laminin_G_2 | pfam02210 | Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ... |
1365-1506 | 1.19e-19 | |||||
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily. Pssm-ID: 460494 [Multi-domain] Cd Length: 126 Bit Score: 87.09 E-value: 1.19e-19
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| Cadherin | pfam00028 | Cadherin domain; |
789-882 | 4.86e-19 | |||||
Cadherin domain; Pssm-ID: 394985 [Multi-domain] Cd Length: 92 Bit Score: 83.89 E-value: 4.86e-19
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| Cadherin | pfam00028 | Cadherin domain; |
380-470 | 1.81e-18 | |||||
Cadherin domain; Pssm-ID: 394985 [Multi-domain] Cd Length: 92 Bit Score: 82.35 E-value: 1.81e-18
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| CA | smart00112 | Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ... |
915-998 | 1.40e-16 | |||||
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium. Pssm-ID: 214520 [Multi-domain] Cd Length: 81 Bit Score: 76.62 E-value: 1.40e-16
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| CA | smart00112 | Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ... |
197-268 | 3.31e-13 | |||||
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium. Pssm-ID: 214520 [Multi-domain] Cd Length: 81 Bit Score: 66.99 E-value: 3.31e-13
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| Cadherin | pfam00028 | Cadherin domain; |
897-990 | 4.96e-13 | |||||
Cadherin domain; Pssm-ID: 394985 [Multi-domain] Cd Length: 92 Bit Score: 66.94 E-value: 4.96e-13
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| HormR | smart00008 | Domain present in hormone receptors; |
1917-1974 | 1.00e-12 | |||||
Domain present in hormone receptors; Pssm-ID: 214468 Cd Length: 70 Bit Score: 65.23 E-value: 1.00e-12
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| GPS | smart00303 | G-protein-coupled receptor proteolytic site domain; Present in latrophilin/CL-1, sea urchin ... |
2170-2218 | 2.07e-11 | |||||
G-protein-coupled receptor proteolytic site domain; Present in latrophilin/CL-1, sea urchin REJ and polycystin. Pssm-ID: 197639 Cd Length: 49 Bit Score: 60.86 E-value: 2.07e-11
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| Cadherin | pfam00028 | Cadherin domain; |
170-261 | 8.95e-11 | |||||
Cadherin domain; Pssm-ID: 394985 [Multi-domain] Cd Length: 92 Bit Score: 60.39 E-value: 8.95e-11
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| EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
1252-1287 | 3.89e-09 | |||||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. Pssm-ID: 238011 Cd Length: 38 Bit Score: 54.18 E-value: 3.89e-09
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| LamG | cd00110 | Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ... |
1582-1716 | 1.08e-08 | |||||
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules. Pssm-ID: 238058 [Multi-domain] Cd Length: 151 Bit Score: 56.27 E-value: 1.08e-08
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| LamG | smart00282 | Laminin G domain; |
1600-1718 | 1.81e-08 | |||||
Laminin G domain; Pssm-ID: 214598 [Multi-domain] Cd Length: 132 Bit Score: 55.04 E-value: 1.81e-08
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| EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
1252-1287 | 9.05e-08 | |||||
Calcium-binding EGF-like domain; Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 50.32 E-value: 9.05e-08
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| 7tmB2_Adhesion | cd15040 | adhesion receptors, subfamily B2 of the class B family of seven-transmembrane G ... |
2237-2455 | 1.29e-07 | |||||
adhesion receptors, subfamily B2 of the class B family of seven-transmembrane G protein-coupled receptors; The B2 subfamily of class B GPCRs consists of cell-adhesion receptors with 33 members in humans and vertebrates. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing a variety of structural motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, linked to a class B seven-transmembrane domain. These include, for example, EGF (epidermal growth factor)-like domains in CD97, Celsr1 (cadherin family member), Celsr2, Celsr3, EMR1 (EGF-module-containing mucin-like hormone receptor-like 1), EMR2, EMR3, and Flamingo; two laminin A G-type repeats and nine cadherin domains in Flamingo and its human orthologs Celsr1, Celsr2 and Celsr3; olfactomedin-like domains in the latrotoxin receptors; and five or four thrombospondin type 1 repeats in BAI1 (brain-specific angiogenesis inhibitor 1), BAI2 and BAI3. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. Pssm-ID: 320168 [Multi-domain] Cd Length: 253 Bit Score: 55.27 E-value: 1.29e-07
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| HRM | pfam02793 | Hormone receptor domain; This extracellular domain contains four conserved cysteines that ... |
1917-1969 | 1.99e-06 | |||||
Hormone receptor domain; This extracellular domain contains four conserved cysteines that probably for disulphide bridges. The domain is found in a variety of hormone receptors. It may be a ligand binding domain. Pssm-ID: 397086 Cd Length: 64 Bit Score: 47.36 E-value: 1.99e-06
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| EGF | pfam00008 | EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ... |
1255-1285 | 6.13e-06 | |||||
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains. Pssm-ID: 394967 Cd Length: 31 Bit Score: 44.68 E-value: 6.13e-06
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| EGF_Lam | cd00055 | Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
1865-1911 | 9.46e-06 | |||||
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies Pssm-ID: 238012 Cd Length: 50 Bit Score: 44.65 E-value: 9.46e-06
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| EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
1774-1808 | 2.06e-05 | |||||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. Pssm-ID: 238011 Cd Length: 38 Bit Score: 43.39 E-value: 2.06e-05
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| 7tm_2 | pfam00002 | 7 transmembrane receptor (Secretin family); This family is known as Family B, the ... |
2237-2423 | 3.89e-05 | |||||
7 transmembrane receptor (Secretin family); This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors (GCPRs). They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families are recognized. Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways. Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97; calcium-independent receptors for latrotoxin, and brain-specific angiogenesis inhibitors amongst others. Subfamily B3 includes Methuselah and other Drosophila proteins. Other than the typical seven-transmembrane region, characteriztic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling. Pssm-ID: 459625 [Multi-domain] Cd Length: 248 Bit Score: 47.66 E-value: 3.89e-05
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| Laminin_G_2 | pfam02210 | Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ... |
1605-1718 | 1.70e-04 | |||||
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily. Pssm-ID: 460494 [Multi-domain] Cd Length: 126 Bit Score: 43.56 E-value: 1.70e-04
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| EGF | smart00181 | Epidermal growth factor-like domain; |
1774-1808 | 6.08e-04 | |||||
Epidermal growth factor-like domain; Pssm-ID: 214544 Cd Length: 35 Bit Score: 39.42 E-value: 6.08e-04
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| EGF_Lam | smart00180 | Laminin-type epidermal growth factor-like domai; |
1865-1896 | 5.22e-03 | |||||
Laminin-type epidermal growth factor-like domai; Pssm-ID: 214543 Cd Length: 46 Bit Score: 36.91 E-value: 5.22e-03
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| Laminin_EGF | pfam00053 | Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
1865-1896 | 9.12e-03 | |||||
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. Pssm-ID: 395007 Cd Length: 49 Bit Score: 36.56 E-value: 9.12e-03
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| Name | Accession | Description | Interval | E-value | |||||
| Cadherin_repeat | cd11304 | Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ... |
274-371 | 1.26e-37 | |||||
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. Pssm-ID: 206637 [Multi-domain] Cd Length: 98 Bit Score: 137.06 E-value: 1.26e-37
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| Cadherin_repeat | cd11304 | Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ... |
686-780 | 2.86e-32 | |||||
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. Pssm-ID: 206637 [Multi-domain] Cd Length: 98 Bit Score: 122.04 E-value: 2.86e-32
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| Cadherin_repeat | cd11304 | Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ... |
486-577 | 4.69e-32 | |||||
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. Pssm-ID: 206637 [Multi-domain] Cd Length: 98 Bit Score: 121.27 E-value: 4.69e-32
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| Cadherin_repeat | cd11304 | Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ... |
788-888 | 3.72e-31 | |||||
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. Pssm-ID: 206637 [Multi-domain] Cd Length: 98 Bit Score: 118.57 E-value: 3.72e-31
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| Cadherin_repeat | cd11304 | Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ... |
379-475 | 3.33e-28 | |||||
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. Pssm-ID: 206637 [Multi-domain] Cd Length: 98 Bit Score: 110.48 E-value: 3.33e-28
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| CA | smart00112 | Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ... |
294-373 | 1.70e-27 | |||||
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium. Pssm-ID: 214520 [Multi-domain] Cd Length: 81 Bit Score: 107.82 E-value: 1.70e-27
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| Cadherin_repeat | cd11304 | Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ... |
896-996 | 2.75e-26 | |||||
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. Pssm-ID: 206637 [Multi-domain] Cd Length: 98 Bit Score: 104.70 E-value: 2.75e-26
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| CA | smart00112 | Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ... |
503-579 | 2.90e-26 | |||||
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium. Pssm-ID: 214520 [Multi-domain] Cd Length: 81 Bit Score: 104.35 E-value: 2.90e-26
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| Cadherin | pfam00028 | Cadherin domain; |
275-365 | 1.41e-24 | |||||
Cadherin domain; Pssm-ID: 394985 [Multi-domain] Cd Length: 92 Bit Score: 99.68 E-value: 1.41e-24
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| CA | smart00112 | Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ... |
705-782 | 6.05e-24 | |||||
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium. Pssm-ID: 214520 [Multi-domain] Cd Length: 81 Bit Score: 97.42 E-value: 6.05e-24
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| Cadherin | pfam00028 | Cadherin domain; |
687-774 | 2.17e-23 | |||||
Cadherin domain; Pssm-ID: 394985 [Multi-domain] Cd Length: 92 Bit Score: 96.22 E-value: 2.17e-23
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| LamG | cd00110 | Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ... |
1333-1504 | 3.41e-23 | |||||
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules. Pssm-ID: 238058 [Multi-domain] Cd Length: 151 Bit Score: 97.87 E-value: 3.41e-23
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| LamG | smart00282 | Laminin G domain; |
1354-1506 | 6.20e-23 | |||||
Laminin G domain; Pssm-ID: 214598 [Multi-domain] Cd Length: 132 Bit Score: 96.64 E-value: 6.20e-23
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| Cadherin_repeat | cd11304 | Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ... |
170-266 | 1.68e-22 | |||||
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. Pssm-ID: 206637 [Multi-domain] Cd Length: 98 Bit Score: 93.92 E-value: 1.68e-22
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| CA | smart00112 | Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ... |
807-890 | 2.62e-21 | |||||
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium. Pssm-ID: 214520 [Multi-domain] Cd Length: 81 Bit Score: 90.10 E-value: 2.62e-21
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| Cadherin | pfam00028 | Cadherin domain; |
486-571 | 3.24e-21 | |||||
Cadherin domain; Pssm-ID: 394985 [Multi-domain] Cd Length: 92 Bit Score: 90.05 E-value: 3.24e-21
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| CA | smart00112 | Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ... |
398-477 | 4.00e-20 | |||||
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium. Pssm-ID: 214520 [Multi-domain] Cd Length: 81 Bit Score: 86.63 E-value: 4.00e-20
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| Laminin_G_2 | pfam02210 | Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ... |
1365-1506 | 1.19e-19 | |||||
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily. Pssm-ID: 460494 [Multi-domain] Cd Length: 126 Bit Score: 87.09 E-value: 1.19e-19
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| Cadherin | pfam00028 | Cadherin domain; |
789-882 | 4.86e-19 | |||||
Cadherin domain; Pssm-ID: 394985 [Multi-domain] Cd Length: 92 Bit Score: 83.89 E-value: 4.86e-19
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| Cadherin | pfam00028 | Cadherin domain; |
380-470 | 1.81e-18 | |||||
Cadherin domain; Pssm-ID: 394985 [Multi-domain] Cd Length: 92 Bit Score: 82.35 E-value: 1.81e-18
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| CA | smart00112 | Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ... |
915-998 | 1.40e-16 | |||||
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium. Pssm-ID: 214520 [Multi-domain] Cd Length: 81 Bit Score: 76.62 E-value: 1.40e-16
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| CA | smart00112 | Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ... |
197-268 | 3.31e-13 | |||||
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium. Pssm-ID: 214520 [Multi-domain] Cd Length: 81 Bit Score: 66.99 E-value: 3.31e-13
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| Cadherin | pfam00028 | Cadherin domain; |
897-990 | 4.96e-13 | |||||
Cadherin domain; Pssm-ID: 394985 [Multi-domain] Cd Length: 92 Bit Score: 66.94 E-value: 4.96e-13
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| HormR | smart00008 | Domain present in hormone receptors; |
1917-1974 | 1.00e-12 | |||||
Domain present in hormone receptors; Pssm-ID: 214468 Cd Length: 70 Bit Score: 65.23 E-value: 1.00e-12
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| GPS | smart00303 | G-protein-coupled receptor proteolytic site domain; Present in latrophilin/CL-1, sea urchin ... |
2170-2218 | 2.07e-11 | |||||
G-protein-coupled receptor proteolytic site domain; Present in latrophilin/CL-1, sea urchin REJ and polycystin. Pssm-ID: 197639 Cd Length: 49 Bit Score: 60.86 E-value: 2.07e-11
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| Cadherin | pfam00028 | Cadherin domain; |
170-261 | 8.95e-11 | |||||
Cadherin domain; Pssm-ID: 394985 [Multi-domain] Cd Length: 92 Bit Score: 60.39 E-value: 8.95e-11
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| Laminin_G_1 | pfam00054 | Laminin G domain; |
1359-1509 | 1.07e-10 | |||||
Laminin G domain; Pssm-ID: 395008 [Multi-domain] Cd Length: 131 Bit Score: 61.56 E-value: 1.07e-10
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| EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
1252-1287 | 3.89e-09 | |||||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. Pssm-ID: 238011 Cd Length: 38 Bit Score: 54.18 E-value: 3.89e-09
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| LamG | cd00110 | Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ... |
1582-1716 | 1.08e-08 | |||||
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules. Pssm-ID: 238058 [Multi-domain] Cd Length: 151 Bit Score: 56.27 E-value: 1.08e-08
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| LamG | smart00282 | Laminin G domain; |
1600-1718 | 1.81e-08 | |||||
Laminin G domain; Pssm-ID: 214598 [Multi-domain] Cd Length: 132 Bit Score: 55.04 E-value: 1.81e-08
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| EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
1252-1287 | 9.05e-08 | |||||
Calcium-binding EGF-like domain; Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 50.32 E-value: 9.05e-08
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| 7tmB2_Adhesion | cd15040 | adhesion receptors, subfamily B2 of the class B family of seven-transmembrane G ... |
2237-2455 | 1.29e-07 | |||||
adhesion receptors, subfamily B2 of the class B family of seven-transmembrane G protein-coupled receptors; The B2 subfamily of class B GPCRs consists of cell-adhesion receptors with 33 members in humans and vertebrates. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing a variety of structural motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, linked to a class B seven-transmembrane domain. These include, for example, EGF (epidermal growth factor)-like domains in CD97, Celsr1 (cadherin family member), Celsr2, Celsr3, EMR1 (EGF-module-containing mucin-like hormone receptor-like 1), EMR2, EMR3, and Flamingo; two laminin A G-type repeats and nine cadherin domains in Flamingo and its human orthologs Celsr1, Celsr2 and Celsr3; olfactomedin-like domains in the latrotoxin receptors; and five or four thrombospondin type 1 repeats in BAI1 (brain-specific angiogenesis inhibitor 1), BAI2 and BAI3. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. Pssm-ID: 320168 [Multi-domain] Cd Length: 253 Bit Score: 55.27 E-value: 1.29e-07
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| 7tm_classB | cd13952 | class B family of seven-transmembrane G protein-coupled receptors; The class B of ... |
2236-2454 | 1.93e-07 | |||||
class B family of seven-transmembrane G protein-coupled receptors; The class B of seven-transmembrane GPCRs is classified into three major subfamilies: subfamily B1 (secretin-like receptor family), B2 (adhesion family), and B3 (Methuselah-like family). The class B receptors have been identified in all the vertebrates, from fishes to mammals, as well as invertebrates including Caenorhabditis elegans and Drosophila melanogaster, but are not present in plants, fungi or prokaryotes. The B1 subfamily comprises receptors for polypeptide hormones of 27-141 amino-acid residues such as secretin, glucagon, glucagon-like peptide (GLP), calcitonin gene-related peptide, parathyroid hormone (PTH), and corticotropin-releasing factor. These receptors contain the large N-terminal extracellular domain (ECD), which plays a critical role in hormone recognition by binding to the C-terminal portion of the peptide. On the other hand, the N-terminal segment of the hormone induces receptor activation by interacting with the receptor transmembrane domains and connecting extracellular loops, triggering intracellular signaling pathways. All members of the subfamily B1 receptors preferentially couple to G proteins of G(s) family, which positively stimulate adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. The subfamily B2 consists of cell-adhesion receptors with 33 members in humans and vertebrates. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing a variety of structural motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, linked to a class B seven-transmembrane domain. These include, for example, EGF (epidermal growth factor)-like domains in CD97, Celsr1 (cadherin family member), Celsr2, Celsr3, EMR1 (EGF-module-containing mucin-like hormone receptor-like 1), EMR2, EMR3, and Flamingo; two laminin A G-type repeats and nine cadherin domains in Flamingo and its human orthologs Celsr1, Celsr2 and Celsr3; olfactomedin-like domains in the latrotoxin receptors; and five or four thrombospondin type 1 repeats in BAI1 (brain-specific angiogenesis inhibitor 1), BAI2 and BAI3. Almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. Furthermore, the subfamily B3 includes Methuselah (Mth) protein, which was originally identified in Drosophila as a GPCR affecting stress resistance and aging, and its closely related proteins. Pssm-ID: 410627 [Multi-domain] Cd Length: 260 Bit Score: 54.91 E-value: 1.93e-07
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| 7tmB2_CELSR1 | cd15991 | Cadherin EGF LAG seven-pass G-type receptor 1, member of the class B2 family of ... |
2230-2423 | 1.11e-06 | |||||
Cadherin EGF LAG seven-pass G-type receptor 1, member of the class B2 family of seven-transmembrane G protein-coupled receptors; The group IV adhesion GPCRs include the cadherin EGF LAG seven-pass G-type receptors (CELSRs) and their Drosophila homolog Flamingo (also known as Starry night). These receptors are also classified as that belongs to the EGF-TM7 group of subfamily B2 adhesion GPCRs, because they contain EGF-like domains. Functionally, the group IV receptors act as key regulators of many physiological processes such as endocrine cell differentiation, neuronal migration, dendrite growth, axon, guidance, lymphatic vessel and valve formation, and planar cell polarity (PCP) during embryonic development. Three mammalian orthologs of Flamingo, Celsr1-3, are widely expressed in the nervous system from embryonic development until the adult stage. Each Celsr exhibits different expression patterns in the developing brain, suggesting that they serve distinct functions. Mutations of CELSR1 cause neural tube defects in the nervous system, while mutations of CELSR2 are associated with coronary heart disease. Moreover, CELSR1 and several other PCP signaling molecules, such as dishevelled, prickle, frizzled, have been shown to be upregulated in B lymphocytes of chronic lymphocytic leukemia patients. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. In the case of CELSR/Flamingo/Starry night, their extracellular domains comprise nine cadherin repeats linked to a series of epidermal growth factor (EGF)-like and laminin globular (G)-like domains. The cadherin repeats contain sequence motifs that mediate calcium-dependent cell-cell adhesion by homophilic interactions. Moreover, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. Pssm-ID: 320657 [Multi-domain] Cd Length: 254 Bit Score: 52.54 E-value: 1.11e-06
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| HRM | pfam02793 | Hormone receptor domain; This extracellular domain contains four conserved cysteines that ... |
1917-1969 | 1.99e-06 | |||||
Hormone receptor domain; This extracellular domain contains four conserved cysteines that probably for disulphide bridges. The domain is found in a variety of hormone receptors. It may be a ligand binding domain. Pssm-ID: 397086 Cd Length: 64 Bit Score: 47.36 E-value: 1.99e-06
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| EGF | pfam00008 | EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ... |
1255-1285 | 6.13e-06 | |||||
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains. Pssm-ID: 394967 Cd Length: 31 Bit Score: 44.68 E-value: 6.13e-06
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| EGF | cd00053 | Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ... |
1254-1287 | 9.00e-06 | |||||
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium. Pssm-ID: 238010 Cd Length: 36 Bit Score: 44.39 E-value: 9.00e-06
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| EGF_Lam | cd00055 | Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
1865-1911 | 9.46e-06 | |||||
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies Pssm-ID: 238012 Cd Length: 50 Bit Score: 44.65 E-value: 9.46e-06
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| EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
1774-1808 | 2.06e-05 | |||||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. Pssm-ID: 238011 Cd Length: 38 Bit Score: 43.39 E-value: 2.06e-05
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| 7tmB2_CELSR_Adhesion_IV | cd15441 | cadherin EGF LAG seven-pass G-type receptors, group IV adhesion GPCRs, member of the class B2 ... |
2233-2450 | 3.48e-05 | |||||
cadherin EGF LAG seven-pass G-type receptors, group IV adhesion GPCRs, member of the class B2 family of seven-transmembrane G protein-coupled receptors; The group IV adhesion GPCRs include the cadherin EGF LAG seven-pass G-type receptors (CELSRs) and their Drosophila homolog Flamingo (also known as Starry night). These receptors are also classified as that belongs to the EGF-TM7 group of subfamily B2 adhesion GPCRs, because they contain EGF-like domains. Functionally, the group IV receptors act as key regulators of many physiological processes such as endocrine cell differentiation, neuronal migration, dendrite growth, axon, guidance, lymphatic vessel and valve formation, and planar cell polarity (PCP) during embryonic development. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. In the case of CELSR/Flamingo/Starry night, their extracellular domains comprise nine cadherin repeats linked to a series of epidermal growth factor (EGF)-like and laminin globular (G)-like domains. The cadherin repeats contain sequence motifs that mediate calcium-dependent cell-cell adhesion by homophilic interactions. Moreover, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. Three mammalian orthologs of Flamingo, Celsr1-3, are widely expressed in the nervous system from embryonic development until the adult stage. Each Celsr exhibits different expression patterns in the developing brain, suggesting that they serve distinct functions. Mutations of CELSR1 cause neural tube defects in the nervous system, while mutations of CELSR2 are associated with coronary heart disease. Moreover, CELSR1 and several other PCP signaling molecules, such as dishevelled, prickle, frizzled, have been shown to be upregulated in B lymphocytes of chronic lymphocytic leukemia patients. Celsr3 is expressed in both the developing and adult mouse brain. It has been functionally implicated in proper neuron migration and axon guidance in the CNS. Pssm-ID: 320557 [Multi-domain] Cd Length: 254 Bit Score: 48.02 E-value: 3.48e-05
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| 7tm_2 | pfam00002 | 7 transmembrane receptor (Secretin family); This family is known as Family B, the ... |
2237-2423 | 3.89e-05 | |||||
7 transmembrane receptor (Secretin family); This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors (GCPRs). They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families are recognized. Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways. Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97; calcium-independent receptors for latrotoxin, and brain-specific angiogenesis inhibitors amongst others. Subfamily B3 includes Methuselah and other Drosophila proteins. Other than the typical seven-transmembrane region, characteriztic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling. Pssm-ID: 459625 [Multi-domain] Cd Length: 248 Bit Score: 47.66 E-value: 3.89e-05
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| CA_like | cd00031 | Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ... |
792-888 | 5.70e-05 | |||||
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan. Pssm-ID: 206635 Cd Length: 98 Bit Score: 44.26 E-value: 5.70e-05
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| hEGF | pfam12661 | Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ... |
1260-1281 | 9.40e-05 | |||||
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue. Pssm-ID: 463660 Cd Length: 22 Bit Score: 41.17 E-value: 9.40e-05
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| 7tmB2_CELSR2 | cd15992 | Cadherin EGF LAG seven-pass G-type receptor 2, member of the class B2 family of ... |
2236-2319 | 1.25e-04 | |||||
Cadherin EGF LAG seven-pass G-type receptor 2, member of the class B2 family of seven-transmembrane G protein-coupled receptors; The group IV adhesion GPCRs include the cadherin EGF LAG seven-pass G-type receptors (CELSRs) and their Drosophila homolog Flamingo (also known as Starry night). These receptors are also classified as that belongs to the EGF-TM7 group of subfamily B2 adhesion GPCRs, because they contain EGF-like domains. Functionally, the group IV receptors act as key regulators of many physiological processes such as endocrine cell differentiation, neuronal migration, dendrite growth, axon, guidance, lymphatic vessel and valve formation, and planar cell polarity (PCP) during embryonic development. Three mammalian orthologs of Flamingo, Celsr1-3, are widely expressed in the nervous system from embryonic development until the adult stage. Each Celsr exhibits different expression patterns in the developing brain, suggesting that they serve distinct functions. Mutations of CELSR1 cause neural tube defects in the nervous system, while mutations of CELSR2 are associated with coronary heart disease. Moreover, CELSR1 and several other PCP signaling molecules, such as dishevelled, prickle, frizzled, have been shown to be upregulated in B lymphocytes of chronic lymphocytic leukemia patients. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. In the case of CELSR/Flamingo/Starry night, their extracellular domains comprise nine cadherin repeats linked to a series of epidermal growth factor (EGF)-like and laminin globular (G)-like domains. The cadherin repeats contain sequence motifs that mediate calcium-dependent cell-cell adhesion by homophilic interactions. Moreover, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. Pssm-ID: 320658 Cd Length: 255 Bit Score: 46.35 E-value: 1.25e-04
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| CA_like | cd00031 | Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ... |
294-371 | 1.58e-04 | |||||
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan. Pssm-ID: 206635 Cd Length: 98 Bit Score: 43.10 E-value: 1.58e-04
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| Laminin_G_2 | pfam02210 | Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ... |
1605-1718 | 1.70e-04 | |||||
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily. Pssm-ID: 460494 [Multi-domain] Cd Length: 126 Bit Score: 43.56 E-value: 1.70e-04
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| 7tmB2_CELSR3 | cd15993 | Cadherin EGF LAG seven-pass G-type receptor 3, member of the class B2 family of ... |
2230-2449 | 4.43e-04 | |||||
Cadherin EGF LAG seven-pass G-type receptor 3, member of the class B2 family of seven-transmembrane G protein-coupled receptors; The group IV adhesion GPCRs include the cadherin EGF LAG seven-pass G-type receptors (CELSRs) and their Drosophila homolog Flamingo (also known as Starry night). These receptors are also classified as that belongs to the EGF-TM7 group of subfamily B2 adhesion GPCRs, because they contain EGF-like domains. Functionally, the group IV receptors act as key regulators of many physiological processes such as endocrine cell differentiation, neuronal migration, dendrite growth, axon, guidance, lymphatic vessel and valve formation, and planar cell polarity (PCP) during embryonic development. Three mammalian orthologs of Flamingo, Celsr1-3, are widely expressed in the nervous system from embryonic development until the adult stage. Each Celsr exhibits different expression patterns in the developing brain, suggesting that they serve distinct functions. Mutations of CELSR1 cause neural tube defects in the nervous system, while mutations of CELSR2 are associated with coronary heart disease. Moreover, CELSR1 and several other PCP signaling molecules, such as dishevelled, prickle, frizzled, have been shown to be upregulated in B lymphocytes of chronic lymphocytic leukemia patients. Celsr3 is expressed in both the developing and adult mouse brain. It has been functionally implicated in proper neuronal migration and axon guidance in the CNS. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. In the case of CELSR/Flamingo/Starry night, their extracellular domains comprise nine cadherin repeats linked to a series of epidermal growth factor (EGF)-like and laminin globular (G)-like domains. The cadherin repeats contain sequence motifs that mediate calcium-dependent cell-cell adhesion by homophilic interactions. Moreover, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. Pssm-ID: 320659 [Multi-domain] Cd Length: 254 Bit Score: 44.45 E-value: 4.43e-04
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| Cadherin_4 | pfam17803 | Bacterial cadherin-like domain; This entry contains numerous bacterial cadherin-like domains ... |
359-433 | 4.94e-04 | |||||
Bacterial cadherin-like domain; This entry contains numerous bacterial cadherin-like domains found in extracelullar proteins. Pssm-ID: 465514 [Multi-domain] Cd Length: 71 Bit Score: 40.63 E-value: 4.94e-04
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| 7tmB2_Latrophilin-1 | cd16007 | Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled ... |
2265-2388 | 5.34e-04 | |||||
Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors; Latrophilins (also called lectomedins or latrotoxin receptors) belong to Group I adhesion GPCRs, which also include ETL (EGF-TM7-latrophilin-related protein). These receptors are a member of the adhesion family (subclass B2) that belongs to the class B GPCRs. Three subtypes of latrophilins have been identified: LPH1 (latrophilin-1), LPH2, and LPH3. The latrophilin-1 is a brain-specific calcium-independent receptor of alpha-latrotoxin, a potent presynaptic neurotoxin from the venom of the black widow spider that induces massive neurotransmitter release from sensory and motor neurons as well as endocrine cells, leading to nerve-terminal degeneration. Latrophilin-2 and -3, although sharing strong sequence homology to latrophilin-1, do not bind alpha-latrotoxin. While latrophilin-3 is also brain specific, latrophilin-2 is ubiquitously distributed. The endogenous ligands for these two receptors are unknown. ETL, a seven transmembrane receptor containing EGF-like repeats is highly expressed in heart, where developmentally regulated, as well as in normal smooth cells. The function of the ETL is unknown. All adhesion GPCRs possess large N-terminal extracellular domains containing multiple structural motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, coupled to a seven-transmembrane domain. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. Pssm-ID: 320673 [Multi-domain] Cd Length: 258 Bit Score: 44.53 E-value: 5.34e-04
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| EGF | smart00181 | Epidermal growth factor-like domain; |
1774-1808 | 6.08e-04 | |||||
Epidermal growth factor-like domain; Pssm-ID: 214544 Cd Length: 35 Bit Score: 39.42 E-value: 6.08e-04
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| EGF_Lam | smart00180 | Laminin-type epidermal growth factor-like domai; |
1261-1299 | 6.86e-04 | |||||
Laminin-type epidermal growth factor-like domai; Pssm-ID: 214543 Cd Length: 46 Bit Score: 39.60 E-value: 6.86e-04
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| CA_like | cd00031 | Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ... |
486-577 | 7.11e-04 | |||||
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan. Pssm-ID: 206635 Cd Length: 98 Bit Score: 41.18 E-value: 7.11e-04
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| CA_like | cd00031 | Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ... |
710-780 | 7.69e-04 | |||||
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan. Pssm-ID: 206635 Cd Length: 98 Bit Score: 41.18 E-value: 7.69e-04
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| EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
1774-1808 | 8.57e-04 | |||||
Calcium-binding EGF-like domain; Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 39.15 E-value: 8.57e-04
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| EGF | smart00181 | Epidermal growth factor-like domain; |
1254-1287 | 1.23e-03 | |||||
Epidermal growth factor-like domain; Pssm-ID: 214544 Cd Length: 35 Bit Score: 38.65 E-value: 1.23e-03
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| EGF | cd00053 | Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ... |
1774-1808 | 1.85e-03 | |||||
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium. Pssm-ID: 238010 Cd Length: 36 Bit Score: 37.84 E-value: 1.85e-03
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| EGF_Lam | cd00055 | Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
1261-1299 | 2.13e-03 | |||||
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies Pssm-ID: 238012 Cd Length: 50 Bit Score: 38.10 E-value: 2.13e-03
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| 7tmB2_GPR133-like_Adhesion_V | cd15933 | orphan GPR133 and related proteins, group V adhesion GPCRs, member of class B2 family of ... |
2233-2316 | 2.28e-03 | |||||
orphan GPR133 and related proteins, group V adhesion GPCRs, member of class B2 family of seven-transmembrane G protein-coupled receptors; group V adhesion GPCRs include orphan receptors GPR133, GPR144, and closely related proteins. The function of GPR144 has not yet been characterized, whereas GPR133 is highly expressed in the pituitary gland and is coupled to the G(s) protein, leading to activation of adenylate cyclase pathway. Moreover, genetic variations in the GPR133 have been reported to be associated with adult height and heart rate. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in ligand recognition as well as cell-cell adhesion and cell-matrix interactions, linked by a stalk region to a class B seven-transmembrane domain. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. However, several adhesion GPCRs, including GPR 111, GPR115, and CELSR1, are predicted to be non-cleavable at the GAIN domain because of the lack of a consensus catalytic triad sequence (His-Leu-Ser/Thr) within their GPS. Pssm-ID: 320599 [Multi-domain] Cd Length: 252 Bit Score: 42.31 E-value: 2.28e-03
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| EGF_2 | pfam07974 | EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
1260-1286 | 2.67e-03 | |||||
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. Pssm-ID: 400365 Cd Length: 26 Bit Score: 37.33 E-value: 2.67e-03
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| 7tmB1_hormone_R | cd15041 | The subfamily B1 of hormone receptors (secretin-like), member of the class B family ... |
2236-2376 | 3.63e-03 | |||||
The subfamily B1 of hormone receptors (secretin-like), member of the class B family seven-transmembrane G protein-coupled receptors; The B1 subfamily of class B GPCRs, also referred to as secretin-like receptor family, includes receptors for polypeptide hormones of 27-141 amino-acid residues such as secretin, glucagon, glucagon-like peptide (GLP), calcitonin gene-related peptide, parathyroid hormone (PTH), and corticotropin-releasing factor. These receptors contain the large N-terminal extracellular domain (ECD), which plays a critical role in hormone recognition by binding to the C-terminal portion of the peptide. On the other hand, the N-terminal segment of the hormone induces receptor activation by interacting with the receptor transmembrane domains and connecting extracellular loops, triggering intracellular signaling pathways. All members of this subfamily preferentially couple to G proteins of G(s) family, which positively stimulate adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. Moreover, the B1 subfamily receptors play key roles in hormone homeostasis and are promising drug targets in various human diseases including diabetes, osteoporosis, obesity, neurodegenerative conditions (Alzheimer###s and Parkinson's), cardiovascular disease, migraine, and psychiatric disorders (anxiety, depression). Furthermore, the subfamilies B2 and B3 consist of receptors that are capable of interacting with epidermal growth factors (EGF) and the Drosophila melanogaster Methuselah gene product (Mth), respectively. The class B GPCRs have been identified in all the vertebrates, from fishes to mammals, as well as invertebrates including Caenorhabditis elegans and Drosophila melanogaster, but are not present in plants, fungi, or prokaryotes. Pssm-ID: 341321 [Multi-domain] Cd Length: 273 Bit Score: 41.83 E-value: 3.63e-03
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| EGF_Lam | smart00180 | Laminin-type epidermal growth factor-like domai; |
1865-1896 | 5.22e-03 | |||||
Laminin-type epidermal growth factor-like domai; Pssm-ID: 214543 Cd Length: 46 Bit Score: 36.91 E-value: 5.22e-03
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| Big_9 | pfam17963 | Bacterial Ig domain; This entry represents a wide variety of bacterial Ig domains. |
358-433 | 6.60e-03 | |||||
Bacterial Ig domain; This entry represents a wide variety of bacterial Ig domains. Pssm-ID: 465590 [Multi-domain] Cd Length: 90 Bit Score: 38.09 E-value: 6.60e-03
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| Laminin_EGF | pfam00053 | Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
1865-1896 | 9.12e-03 | |||||
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. Pssm-ID: 395007 Cd Length: 49 Bit Score: 36.56 E-value: 9.12e-03
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