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Conserved domains on  [gi|17564218|ref|NP_506344|]
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G protein-coupled receptor [Caenorhabditis elegans]

Protein Classification

serpentine receptor class epsilon family protein( domain architecture ID 7368)

serpentine receptor class epsilon (sre) family protein such as Caenorhabditis elegans sre proteins that are thought to be 7-transmembrane, G-protein coupled receptors (GPCRs)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sre super family cl10600
C. elegans Sre G protein-coupled chemoreceptor; Caenorhabditis elegans Sre proteins are ...
 104-276 3.89e-03

C. elegans Sre G protein-coupled chemoreceptor; Caenorhabditis elegans Sre proteins are candidate chemosensory receptors. There are four main recognized groups of such receptors: Odr-10, Sra, Sro, and Srg. Sre (this family), Sra pfam02117 and Srb pfam02175 comprise the Sra group. All of the above receptors are thought to be G protein-coupled seven transmembrane domain proteins. The existence of several different chemosensory receptors underlies the fact that in spite of having only 20-30 chemosensory neurones, C. elegans detects hundreds of different chemicals, with the ability to discern individual chemicals among combinations.


The actual alignment was detected with superfamily member pfam03125:

Pssm-ID: 251743  Cd Length: 363  Bit Score: 38.84  E-value: 3.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564218   104 YMAISYFIPPLIAIgiiERIFATAFSRFYEK-SRYWMtlGYALV-----FACILVYIEFANRhvmmATIPTRNIQVLFAI 177
Cdd:pfam03125 132 YMFSVVFGLLAIAV---ERCFASVFIKDYEKkSRIWI--PVILIiisqfLAISSALFFLFNK----LPVLFIVLPWIICN 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564218   178 ICSWSLILLLF-INRSK-----SKSGRAKSALSERYQVNENLKALR---------IHIPVVCvdtGIQIMFLCSDIFWNT 242
Cdd:pfam03125 203 IISVIVYLFIRrYNQKWykeieNPRRKRNYTLSQRFQVKENLKALKlgkrlvfvvLFIIVLC---GSGILALSFDLIPLL 279

                         170       180       190
                  ....*....|....*....|....*....|....
gi 17564218   243 AQVlnLNYCYDDNIYLHKFvvfrLIGFILQYFIP 276
Cdd:pfam03125 280 RTF--LNHIFENSLFLYPL----LICPTIMFSVP 307
 
Name Accession Description Interval E-value
Sre pfam03125
C. elegans Sre G protein-coupled chemoreceptor; Caenorhabditis elegans Sre proteins are ...
 104-276 3.89e-03

C. elegans Sre G protein-coupled chemoreceptor; Caenorhabditis elegans Sre proteins are candidate chemosensory receptors. There are four main recognized groups of such receptors: Odr-10, Sra, Sro, and Srg. Sre (this family), Sra pfam02117 and Srb pfam02175 comprise the Sra group. All of the above receptors are thought to be G protein-coupled seven transmembrane domain proteins. The existence of several different chemosensory receptors underlies the fact that in spite of having only 20-30 chemosensory neurones, C. elegans detects hundreds of different chemicals, with the ability to discern individual chemicals among combinations.


Pssm-ID: 251743  Cd Length: 363  Bit Score: 38.84  E-value: 3.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564218   104 YMAISYFIPPLIAIgiiERIFATAFSRFYEK-SRYWMtlGYALV-----FACILVYIEFANRhvmmATIPTRNIQVLFAI 177
Cdd:pfam03125 132 YMFSVVFGLLAIAV---ERCFASVFIKDYEKkSRIWI--PVILIiisqfLAISSALFFLFNK----LPVLFIVLPWIICN 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564218   178 ICSWSLILLLF-INRSK-----SKSGRAKSALSERYQVNENLKALR---------IHIPVVCvdtGIQIMFLCSDIFWNT 242
Cdd:pfam03125 203 IISVIVYLFIRrYNQKWykeieNPRRKRNYTLSQRFQVKENLKALKlgkrlvfvvLFIIVLC---GSGILALSFDLIPLL 279

                         170       180       190
                  ....*....|....*....|....*....|....
gi 17564218   243 AQVlnLNYCYDDNIYLHKFvvfrLIGFILQYFIP 276
Cdd:pfam03125 280 RTF--LNHIFENSLFLYPL----LICPTIMFSVP 307
 
Name Accession Description Interval E-value
Sre pfam03125
C. elegans Sre G protein-coupled chemoreceptor; Caenorhabditis elegans Sre proteins are ...
 104-276 3.89e-03

C. elegans Sre G protein-coupled chemoreceptor; Caenorhabditis elegans Sre proteins are candidate chemosensory receptors. There are four main recognized groups of such receptors: Odr-10, Sra, Sro, and Srg. Sre (this family), Sra pfam02117 and Srb pfam02175 comprise the Sra group. All of the above receptors are thought to be G protein-coupled seven transmembrane domain proteins. The existence of several different chemosensory receptors underlies the fact that in spite of having only 20-30 chemosensory neurones, C. elegans detects hundreds of different chemicals, with the ability to discern individual chemicals among combinations.


Pssm-ID: 251743  Cd Length: 363  Bit Score: 38.84  E-value: 3.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564218   104 YMAISYFIPPLIAIgiiERIFATAFSRFYEK-SRYWMtlGYALV-----FACILVYIEFANRhvmmATIPTRNIQVLFAI 177
Cdd:pfam03125 132 YMFSVVFGLLAIAV---ERCFASVFIKDYEKkSRIWI--PVILIiisqfLAISSALFFLFNK----LPVLFIVLPWIICN 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564218   178 ICSWSLILLLF-INRSK-----SKSGRAKSALSERYQVNENLKALR---------IHIPVVCvdtGIQIMFLCSDIFWNT 242
Cdd:pfam03125 203 IISVIVYLFIRrYNQKWykeieNPRRKRNYTLSQRFQVKENLKALKlgkrlvfvvLFIIVLC---GSGILALSFDLIPLL 279

                         170       180       190
                  ....*....|....*....|....*....|....
gi 17564218   243 AQVlnLNYCYDDNIYLHKFvvfrLIGFILQYFIP 276
Cdd:pfam03125 280 RTF--LNHIFENSLFLYPL----LICPTIMFSVP 307
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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