NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|17564464|ref|NP_507247|]
View 

Serpentine Receptor, class H [Caenorhabditis elegans]

Protein Classification

class H serpentine receptor( domain architecture ID 10563391)

class H serpentine receptor (Srh) belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans, and is related to the Str, Stl, and Srd families of 7TM serpentine receptors

CATH:  1.20.1070.10
Gene Ontology:  GO:0004888
PubMed:  10673277|23140243

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
14-312 2.14e-96

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402095  Cd Length: 302  Bit Score: 287.52  E-value: 2.14e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564464    14 TPDFFETVLHVISYISIPVHCYGGFCVFAKTPISMQSVKWSMMNLHLFSCLFDLGVSLFTIPYILFPVLAGYPLGLMQKF 93
Cdd:pfam10318   2 SPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLSYL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564464    94 GVPIEIQVYVVLFVGAFMLVSITIVFENRLFVLVLSDK--TLQRFRTPIYILHYILPIIF-LPALVNIPDQKAGYRNLMD 170
Cdd:pfam10318  82 GVPTPIQFYIGVTSLALVGVSIILLFENRYSILFTNKKriTWKKTRVLYLIFNYIIALLFlIPIYLNIPDQEAAKLKVLK 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564464   171 HFECVPPYV-DIKKVFYLAITKRYFLGGCASFIVAMFVEVWFFAFITNRMLKKQMTKTMSQKTVDLHRKFQRAFILQLLI 249
Cdd:pfam10318 162 KLPCLPPEFfDNPPVFVLAIDSTYFLICIVLLILILIIQILFFVFLTIYYLFKSVKSSLSKKTRKLQKKFFIALIIQVSI 241
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17564464   250 PFIIVFLPICYVGFSCFAEsaFHNQALNNITIIIISSHGFFSTIAMIALHTPYREYTQQLFPF 312
Cdd:pfam10318 242 PLIVILIPLIYILFSIIFG--YYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFKK 302
 
Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
14-312 2.14e-96

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 287.52  E-value: 2.14e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564464    14 TPDFFETVLHVISYISIPVHCYGGFCVFAKTPISMQSVKWSMMNLHLFSCLFDLGVSLFTIPYILFPVLAGYPLGLMQKF 93
Cdd:pfam10318   2 SPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLSYL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564464    94 GVPIEIQVYVVLFVGAFMLVSITIVFENRLFVLVLSDK--TLQRFRTPIYILHYILPIIF-LPALVNIPDQKAGYRNLMD 170
Cdd:pfam10318  82 GVPTPIQFYIGVTSLALVGVSIILLFENRYSILFTNKKriTWKKTRVLYLIFNYIIALLFlIPIYLNIPDQEAAKLKVLK 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564464   171 HFECVPPYV-DIKKVFYLAITKRYFLGGCASFIVAMFVEVWFFAFITNRMLKKQMTKTMSQKTVDLHRKFQRAFILQLLI 249
Cdd:pfam10318 162 KLPCLPPEFfDNPPVFVLAIDSTYFLICIVLLILILIIQILFFVFLTIYYLFKSVKSSLSKKTRKLQKKFFIALIIQVSI 241
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17564464   250 PFIIVFLPICYVGFSCFAEsaFHNQALNNITIIIISSHGFFSTIAMIALHTPYREYTQQLFPF 312
Cdd:pfam10318 242 PLIVILIPLIYILFSIIFG--YYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFKK 302
 
Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
14-312 2.14e-96

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 287.52  E-value: 2.14e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564464    14 TPDFFETVLHVISYISIPVHCYGGFCVFAKTPISMQSVKWSMMNLHLFSCLFDLGVSLFTIPYILFPVLAGYPLGLMQKF 93
Cdd:pfam10318   2 SPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLSYL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564464    94 GVPIEIQVYVVLFVGAFMLVSITIVFENRLFVLVLSDK--TLQRFRTPIYILHYILPIIF-LPALVNIPDQKAGYRNLMD 170
Cdd:pfam10318  82 GVPTPIQFYIGVTSLALVGVSIILLFENRYSILFTNKKriTWKKTRVLYLIFNYIIALLFlIPIYLNIPDQEAAKLKVLK 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564464   171 HFECVPPYV-DIKKVFYLAITKRYFLGGCASFIVAMFVEVWFFAFITNRMLKKQMTKTMSQKTVDLHRKFQRAFILQLLI 249
Cdd:pfam10318 162 KLPCLPPEFfDNPPVFVLAIDSTYFLICIVLLILILIIQILFFVFLTIYYLFKSVKSSLSKKTRKLQKKFFIALIIQVSI 241
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17564464   250 PFIIVFLPICYVGFSCFAEsaFHNQALNNITIIIISSHGFFSTIAMIALHTPYREYTQQLFPF 312
Cdd:pfam10318 242 PLIVILIPLIYILFSIIFG--YYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFKK 302
7TM_GPCR_Sri pfam10327
Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis ...
14-305 4.97e-11

Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Sri is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 313539  Cd Length: 303  Bit Score: 62.56  E-value: 4.97e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564464    14 TPDFFETVLHVISYISIPVHCYGGFCVFAKTPIsMQSVKWSMMNLHLFSCLFDLGVSLFTIPYILFPVLAGYPLGLM-QK 92
Cdd:pfam10327   7 VPFWLILYYHIIGTISLILNLLGIYLIIFKSGK-IDNFRYYLLYFQISCTLTDIHLTFLMQPIPLFPIIAGYCNGFLaTV 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564464    93 FGVPIEIQVYVVLFVGAFMLVSITIVFENRLFVLVlsdKTLQRFRTP--IYILHYILPIIFlPALVNI--------PDQK 162
Cdd:pfam10327  86 FGISSHYLMTIFVFLLSFQLESLLLCFVRKHQAIA---KILSKHVIPkwLYIFLYILCHIF-PFLTAFlfyqsglsREEQ 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564464   163 AGYRNlMDHFECVPPYVDIKKvFYLAITKRYFLGGCASFIVAMFVEVWFFAFITNRMLK--KQMTKTMSQKTVDLHRKFQ 240
Cdd:pfam10327 162 LEYVK-ENYPEYLSQFSSLPN-FAIYDYNPWLIVFGILAIFGGSLSFLILVYLTVDMFRmlKRLRKKISAQTYQKHRAAL 239
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17564464   241 RAFILQLLIPFIIVFLPICYVGFSCFAESafHNQALNNITIIIISSHGFFSTIAMIALHTPYREY 305
Cdd:pfam10327 240 RSLIAQFATSPVCILPPFAFVVVVLFPIE--YSQEISEILLAIFSTHSSVNSIVLILTTPPYRKF 302
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
193-258 6.68e-04

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 40.90  E-value: 6.68e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17564464   193 YFLGGCASFIVAMFVEVWFFAFITNRMLKKQMtKTMSQKTVDLHRKFQRAFILQLLIPFIIVFLPI 258
Cdd:pfam10326 196 IGLLIMTFIIGISFSIIIYCGIKMYFKMKKLK-SLGSEKTRKLQKQLFKALVIQTLIPTILMYIPV 260
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH