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Conserved domains on  [gi|72000294|ref|NP_508017|]
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Gamma-glutamyltransferase [Caenorhabditis elegans]

Protein Classification

gamma-glutamyltransferase family protein( domain architecture ID 10470232)

gamma-glutamyltransferase family protein exhibits gamma-glutamyltranspeptidase and/or cephalosporin acylase and/or glutathione hydrolase activity, all involving the hydrolytic splitting of a peptide-like C-N bond

EC:  3.-.-.-
Gene Ontology:  GO:0016787
MEROPS:  T3
PubMed:  11563810|22527720
SCOP:  4000420

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
G_glu_transpept pfam01019
Gamma-glutamyltranspeptidase;
53-570 0e+00

Gamma-glutamyltranspeptidase;


:

Pssm-ID: 425991  Cd Length: 499  Bit Score: 601.12  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294    53 EILRKGGNSIDASIASMFCLGVVNPQSSGIGGGFLMTYFDQKSGDCYSIDARETAPAAASRDMFL--NDSDGSKYGFKAA 130
Cdd:pfam01019   2 DILRKGGNAVDAAVAAALCLGVVEPHSSGIGGGGFMLIYDAKTGKVLVIDARETAPAAATKDMFDgkGDSKLSLTGGLAV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294   131 GTPGEIAGYWHIFKKFgsGKVTWKELVQPSVKLAREGHPVSPYLATVMKVKERHFRLFPSV-KHWINpeTNDTYQSGDLL 209
Cdd:pfam01019  82 GVPGEVAGLAEAHKRY--GRLPWADLLEPAIKLARDGFPVSPALARALARAEERLRADPGLrKIFLP--TGRVLKAGELL 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294   210 KRPKLAKTLERLGNspNPVQLFYHGEMAKTLAKEFQEGGGLITEQDLANYKVrEYVNSNSNDHfrGTLTMCGGPPPSSFG 289
Cdd:pfam01019 158 KQPALAKTLELIAE--EGPDAFYRGELAQQLVADLQANGGIITAEDLANYRV-KIREPLSADY--GGYTVYSPPPSSGGI 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294   290 VTQLIVSAMSKLFPEGHkddiYNDPKVLHKYIEAMKFAYAQRTL-LGDHDFVKGALElskNLTTPEYTQWVIDRMTDKAQ 368
Cdd:pfam01019 233 ALLQILNILEGFDLSSL----LNSAEYLHLLIEAMKLAYADRTRyLGDPDFVPVPVE---NLLSPEYAKERAKLINPNAA 305
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294   369 SSKNYGgiaqyvPPDHGTSHVSAMDQYGNGVSATTTINRWFGAAVESSEYGILWNDEMDDFSTPGMeNGFGFAPSETNFI 448
Cdd:pfam01019 306 FPSSYA------PEDGGTTHFSVVDRDGNAVSFTSTINLGFGSGVVVPGTGILLNNEMDDFSTPPG-NAFGLDPSPANAI 378
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294   449 EPGKRPMSSMSPMVIFDHvtKKVRMVIGGSGGSKIISALAKSIVRSLIFHDSIKKAIDAPMIHNQFtPDITQLDDEFPIN 528
Cdd:pfam01019 379 APGKRPLSSMAPTIVLDD--GKPVLVVGAPGGSRIISAVLQVIVNVLDLGLDLQQAVDAPRIHHQL-PDVLEVEPGFPEE 455
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....
gi 72000294   529 MKNILEsEYLQKFRNTTGFEGIIQGVNV--LNDGIYACGDYRRK 570
Cdd:pfam01019 456 VLAELE-ARGHKVKVVEDSSSVGAIQIVrrTGGVLYAASDPRRD 498
 
Name Accession Description Interval E-value
G_glu_transpept pfam01019
Gamma-glutamyltranspeptidase;
53-570 0e+00

Gamma-glutamyltranspeptidase;


Pssm-ID: 425991  Cd Length: 499  Bit Score: 601.12  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294    53 EILRKGGNSIDASIASMFCLGVVNPQSSGIGGGFLMTYFDQKSGDCYSIDARETAPAAASRDMFL--NDSDGSKYGFKAA 130
Cdd:pfam01019   2 DILRKGGNAVDAAVAAALCLGVVEPHSSGIGGGGFMLIYDAKTGKVLVIDARETAPAAATKDMFDgkGDSKLSLTGGLAV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294   131 GTPGEIAGYWHIFKKFgsGKVTWKELVQPSVKLAREGHPVSPYLATVMKVKERHFRLFPSV-KHWINpeTNDTYQSGDLL 209
Cdd:pfam01019  82 GVPGEVAGLAEAHKRY--GRLPWADLLEPAIKLARDGFPVSPALARALARAEERLRADPGLrKIFLP--TGRVLKAGELL 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294   210 KRPKLAKTLERLGNspNPVQLFYHGEMAKTLAKEFQEGGGLITEQDLANYKVrEYVNSNSNDHfrGTLTMCGGPPPSSFG 289
Cdd:pfam01019 158 KQPALAKTLELIAE--EGPDAFYRGELAQQLVADLQANGGIITAEDLANYRV-KIREPLSADY--GGYTVYSPPPSSGGI 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294   290 VTQLIVSAMSKLFPEGHkddiYNDPKVLHKYIEAMKFAYAQRTL-LGDHDFVKGALElskNLTTPEYTQWVIDRMTDKAQ 368
Cdd:pfam01019 233 ALLQILNILEGFDLSSL----LNSAEYLHLLIEAMKLAYADRTRyLGDPDFVPVPVE---NLLSPEYAKERAKLINPNAA 305
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294   369 SSKNYGgiaqyvPPDHGTSHVSAMDQYGNGVSATTTINRWFGAAVESSEYGILWNDEMDDFSTPGMeNGFGFAPSETNFI 448
Cdd:pfam01019 306 FPSSYA------PEDGGTTHFSVVDRDGNAVSFTSTINLGFGSGVVVPGTGILLNNEMDDFSTPPG-NAFGLDPSPANAI 378
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294   449 EPGKRPMSSMSPMVIFDHvtKKVRMVIGGSGGSKIISALAKSIVRSLIFHDSIKKAIDAPMIHNQFtPDITQLDDEFPIN 528
Cdd:pfam01019 379 APGKRPLSSMAPTIVLDD--GKPVLVVGAPGGSRIISAVLQVIVNVLDLGLDLQQAVDAPRIHHQL-PDVLEVEPGFPEE 455
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....
gi 72000294   529 MKNILEsEYLQKFRNTTGFEGIIQGVNV--LNDGIYACGDYRRK 570
Cdd:pfam01019 456 VLAELE-ARGHKVKVVEDSSSVGAIQIVrrTGGVLYAASDPRRD 498
Ggt COG0405
Gamma-glutamyltranspeptidase [Amino acid transport and metabolism];
48-569 1.48e-140

Gamma-glutamyltranspeptidase [Amino acid transport and metabolism];


Pssm-ID: 440174  Cd Length: 507  Bit Score: 416.76  E-value: 1.48e-140
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294  48 SKIGGEILRKGGNSIDASIASMFCLGVVNPQSSGIGGGFLMTYFDQKSGDCYSIDARETAPAAASRDMFLNDSDG-SKYG 126
Cdd:COG0405  10 SQAGLEILRAGGNAVDAAVAAAAALAVVEPHSSGIGGGGFALIYDAKDGKVTALDGRGTAPAAATPDMYLDAGDEiPVRG 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294 127 FKAAGTPGEIAGYWHIFKKFgsGKVTWKELVQPSVKLAREGHPVSPYLATVMKVKERHFRLFpsvkhwinPETNDTY--- 203
Cdd:COG0405  90 PLAVGVPGTVAGWEAAHERY--GTLPLAELLAPAIRLAEDGFPVSPRLAALLAAAAERLARD--------PGAAAIFlpd 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294 204 ----QSGDLLKRPKLAKTLERLGNspNPVQLFYHGEMAKTLAKEFQEGGGLITEQDLANYKV--REYVNSNsndhFRGtL 277
Cdd:COG0405 160 grppKAGDILRQPDLAATLRRIAE--EGADAFYRGEIAEAIVAAVQAAGGLLTLEDLAAYRAewREPLSGT----YRG-Y 232
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294 278 TMCGGPPPSSfGVTQLIVSAMSKLFPEGHKDdiYNDPKVLHKYIEAMKFAYAQR-TLLGDHDFVKGALElskNLTTPEYT 356
Cdd:COG0405 233 TVYSMPPPSQ-GIALLQILNILEGFDLAALG--PDSAEYVHLLAEAMKLAFADRdRYLGDPDFVDVPVE---GLLSPAYA 306
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294 357 QwviDRM----TDKAQSSKNYGGIAQYVPPDhgTSHVSAMDQYGNGVSATTTINRWFGAAVESSEYGILWNDEMDDFStp 432
Cdd:COG0405 307 A---ERAalidPDRATPSPRPGDPTGPESGD--TTHLSVVDRDGNAVSLTQSIYGGFGSGVVVPGTGFLLNNRGDDFS-- 379
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294 433 gmengfgFAPSETNFIEPGKRPMSSMSPMVIFDHvtKKVRMVIGGSGGSKIISALAKSIVRSLIFHDSIKKAIDAPMIHN 512
Cdd:COG0405 380 -------LDPGHPNALAPGKRPRSTMSPTIVLKD--GKPVLVFGSPGGSRIPQTVLQVLLNVLDFGMNPQEAVDAPRWHH 450
                       490       500       510       520       530
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 72000294 513 QFTPDITQLDDEFPINMKNILESEYlQKFRNTTGFEGIIQGVNVLNDGIYACG-DYRR 569
Cdd:COG0405 451 QGLPDTLELEPRFPPAVIAALRARG-HKVEVVPDWSGGAQAILRDPDGVLEGAaDPRR 507
g_glut_trans TIGR00066
gamma-glutamyltranspeptidase; Also called gamma-glutamyltranspeptidase (ggt). Some members of ...
42-568 7.92e-109

gamma-glutamyltranspeptidase; Also called gamma-glutamyltranspeptidase (ggt). Some members of this family have antibiotic synthesis or resistance activities. In the case of a cephalosporin acylase from Pseudomonas sp., the enzyme was shown to retain some gamma-glutamyltranspeptidase activity. Other, more distantly related proteins have ggt-related activities and score below the trusted cutoff. [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs]


Pssm-ID: 129176  Cd Length: 516  Bit Score: 335.58  E-value: 7.92e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294    42 SDNAACSKIGGEILRKGGNSIDASIASMFCLGVVNPQSSGIGGGFLMTYFDQKSGDCYSIDARETAPAAASRDMFLNDS- 120
Cdd:TIGR00066   5 SLHALASEIGEDILKEGGNAFDAAVAVGLALAVVEPFMTGLGGGGFMLISGKKTKDTTAIDFRERAPAKATRDMFLDKSg 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294   121 ----DGSKYGFKAAGTPGEIAGYWHIFKKFgsGKVTWKELVQPSVKLAREGHPVSPYLA-TVMKVKERHFRLFPSVKHWI 195
Cdd:TIGR00066  85 nplpGKSLTGGLAIGVPGTVAGLEAALKKY--GTLPLKDLIEPAIKLARNGFPINEALAdTLELYEEVLLTTKEDSKDIF 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294   196 NPeTNDTYQSGDLLKRPKLAKTLERLG-NSPNPvqlFYHGEMAKTLAKEFQEGGGLITEQDLANYKV--REYVNSNsndh 272
Cdd:TIGR00066 163 NP-TGKPLKEGDTLVQKDLAKSLELIAeNGPDA---FYKGDIAESIIDTLQKNGGIMTKKDLAAYDVeiRKPLSGD---- 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294   273 FRG--TLTMcggPPPSSFGVTQL-IVSAMSKL----FPEGHKDDIyndpkvlHKYIEAMKFAYAQRT-LLGDHDFVKGAL 344
Cdd:TIGR00066 235 YRGyqVYTT---PPPSSGGIHLLqALNILENFdlsqYGDGSAETY-------QLLAEAMKLSYADRSrYLGDPEFVDVPL 304
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294   345 ElskNLTTPEYTQWVIDRMTDKAQ--SSKNYGGIAQYVPPdHGTSHVSAMDQYGNGVSATTTINRWFGAAVESSEYGILW 422
Cdd:TIGR00066 305 E---ELLDKRYAKELAQSIKINKVdpKSTIYPGAYQPNEG-SQTTHFSVVDRDGNAVSLTTTINLEFGSGVHAPDTGILL 380
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294   423 NDEMDDFSTpgmengfgfAPSETNFIEPGKRPMSSMSPMVIFDHvtKKVRMVIGGSGGSKIISALAKSIVRSLIFHDSIK 502
Cdd:TIGR00066 381 NNEMDDFSL---------KPGGANAVEPNKRPLSSMAPTIVLKD--GKPDLVVGSPGGSRIITTVLQTIVRHIDYGMPLA 449
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 72000294   503 KAIDAPMIHNQFTPDITQLDDEFPINMKNILESEYLQKFRNTTGFEGIIQGVNVLNDG-IYACGDYR 568
Cdd:TIGR00066 450 EAVSEPRIHHQWLPDELRLEKGFPDDVLQLLKDMGHKVTLKEVFPMGVVQAIRVDPEGwLYGVSDPR 516
PLN02198 PLN02198
glutathione gamma-glutamylcysteinyltransferase
39-534 6.33e-93

glutathione gamma-glutamylcysteinyltransferase


Pssm-ID: 177849  Cd Length: 573  Bit Score: 296.22  E-value: 6.33e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294   39 ALTSDNAACSKIGGEILRKGGNSIDASIASMFCLGVVNPQSSGIGGGFLMTyFDQKSGDCYSIDARETAPAAASRDMFLN 118
Cdd:PLN02198  35 AVATDDGRCSVIGMNVLREGGNAIDASVAAALCLGVVSPASSGIGGGAFTL-IKLANGEEIAYDSRETAPLSATENMYGG 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294  119 DSDGSKYGFKAAGTPGEIAGYWHIFKKFGsgKVTWKELVQPSVKLAREGHPVSPYLATVMkVKERHFRLFPSVKHWINPE 198
Cdd:PLN02198 114 NVELKKKGALSVGVPGEVAGLFTAWKQHG--KLPWKRLVRPAEKLAAEGFKISKYLYMQM-NATRSDILADKGLSDLFVS 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294  199 TNDTYQSGDLLKRPKLAKTLERLgnSPNPVQLFYHGEMAKTLAKEFQEGGGLITEQDLANYKVREYVNSNSNDHFRGTLT 278
Cdd:PLN02198 191 NGELKKPGTICHNPKLALTLRLI--GEYGPKAFYNGTVGVNLVRDIQKSGGIITLKDLQSYRVKVKEPLSADILGYRVLG 268
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294  279 McggPPPSSFGVTQ-LIVSAMSKL-FPEGhkddiYNDPKVLHKYIEAMKFAYAQRTLLGDHDFVKGAlELSKNLTTPEYT 356
Cdd:PLN02198 269 M---PPPSSGGAAMmLILNILAQYgIPSG-----VSGPLGVHRLIEALKHAFAVRMNLGDPDFVDVT-KVVSDMLSPKFA 339
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294  357 QWVIDRMTD-KAQSSKNYGGIAQYVPpDHGTSHVSAMDQYGNGVSATTTINRWFGAAVESSEYGILWNDEMDDFSTPGME 435
Cdd:PLN02198 340 QDLKSKINDnKTFDPKHYGGRWNQID-DHGTSHLSIIDSERNAVSMTSTINGYFGALMLSPSTGIVLNNEMDDFSIPMKS 418
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294  436 NGFGFA--PSETNFIEPGKRPMSSMSPMVIFDhvTKKVRMVIGGSGGSKIISALAKSIVRSLIFHDSIKKAIDAPMIHNQ 513
Cdd:PLN02198 419 GGNLDVppPAPANFIRPGKRPLSSMTPTIVLK--DGKVKAAVGASGGANIIAGTTEVYLNHFFLKMDPLSSVLAPRIYHQ 496
                        490       500       510
                 ....*....|....*....|....*....|
gi 72000294  514 FTPDITQLDD---------EFPINMKNILE 534
Cdd:PLN02198 497 LIPNRASYENwttvyndhfEIPKATRVVLE 526
 
Name Accession Description Interval E-value
G_glu_transpept pfam01019
Gamma-glutamyltranspeptidase;
53-570 0e+00

Gamma-glutamyltranspeptidase;


Pssm-ID: 425991  Cd Length: 499  Bit Score: 601.12  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294    53 EILRKGGNSIDASIASMFCLGVVNPQSSGIGGGFLMTYFDQKSGDCYSIDARETAPAAASRDMFL--NDSDGSKYGFKAA 130
Cdd:pfam01019   2 DILRKGGNAVDAAVAAALCLGVVEPHSSGIGGGGFMLIYDAKTGKVLVIDARETAPAAATKDMFDgkGDSKLSLTGGLAV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294   131 GTPGEIAGYWHIFKKFgsGKVTWKELVQPSVKLAREGHPVSPYLATVMKVKERHFRLFPSV-KHWINpeTNDTYQSGDLL 209
Cdd:pfam01019  82 GVPGEVAGLAEAHKRY--GRLPWADLLEPAIKLARDGFPVSPALARALARAEERLRADPGLrKIFLP--TGRVLKAGELL 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294   210 KRPKLAKTLERLGNspNPVQLFYHGEMAKTLAKEFQEGGGLITEQDLANYKVrEYVNSNSNDHfrGTLTMCGGPPPSSFG 289
Cdd:pfam01019 158 KQPALAKTLELIAE--EGPDAFYRGELAQQLVADLQANGGIITAEDLANYRV-KIREPLSADY--GGYTVYSPPPSSGGI 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294   290 VTQLIVSAMSKLFPEGHkddiYNDPKVLHKYIEAMKFAYAQRTL-LGDHDFVKGALElskNLTTPEYTQWVIDRMTDKAQ 368
Cdd:pfam01019 233 ALLQILNILEGFDLSSL----LNSAEYLHLLIEAMKLAYADRTRyLGDPDFVPVPVE---NLLSPEYAKERAKLINPNAA 305
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294   369 SSKNYGgiaqyvPPDHGTSHVSAMDQYGNGVSATTTINRWFGAAVESSEYGILWNDEMDDFSTPGMeNGFGFAPSETNFI 448
Cdd:pfam01019 306 FPSSYA------PEDGGTTHFSVVDRDGNAVSFTSTINLGFGSGVVVPGTGILLNNEMDDFSTPPG-NAFGLDPSPANAI 378
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294   449 EPGKRPMSSMSPMVIFDHvtKKVRMVIGGSGGSKIISALAKSIVRSLIFHDSIKKAIDAPMIHNQFtPDITQLDDEFPIN 528
Cdd:pfam01019 379 APGKRPLSSMAPTIVLDD--GKPVLVVGAPGGSRIISAVLQVIVNVLDLGLDLQQAVDAPRIHHQL-PDVLEVEPGFPEE 455
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....
gi 72000294   529 MKNILEsEYLQKFRNTTGFEGIIQGVNV--LNDGIYACGDYRRK 570
Cdd:pfam01019 456 VLAELE-ARGHKVKVVEDSSSVGAIQIVrrTGGVLYAASDPRRD 498
Ggt COG0405
Gamma-glutamyltranspeptidase [Amino acid transport and metabolism];
48-569 1.48e-140

Gamma-glutamyltranspeptidase [Amino acid transport and metabolism];


Pssm-ID: 440174  Cd Length: 507  Bit Score: 416.76  E-value: 1.48e-140
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294  48 SKIGGEILRKGGNSIDASIASMFCLGVVNPQSSGIGGGFLMTYFDQKSGDCYSIDARETAPAAASRDMFLNDSDG-SKYG 126
Cdd:COG0405  10 SQAGLEILRAGGNAVDAAVAAAAALAVVEPHSSGIGGGGFALIYDAKDGKVTALDGRGTAPAAATPDMYLDAGDEiPVRG 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294 127 FKAAGTPGEIAGYWHIFKKFgsGKVTWKELVQPSVKLAREGHPVSPYLATVMKVKERHFRLFpsvkhwinPETNDTY--- 203
Cdd:COG0405  90 PLAVGVPGTVAGWEAAHERY--GTLPLAELLAPAIRLAEDGFPVSPRLAALLAAAAERLARD--------PGAAAIFlpd 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294 204 ----QSGDLLKRPKLAKTLERLGNspNPVQLFYHGEMAKTLAKEFQEGGGLITEQDLANYKV--REYVNSNsndhFRGtL 277
Cdd:COG0405 160 grppKAGDILRQPDLAATLRRIAE--EGADAFYRGEIAEAIVAAVQAAGGLLTLEDLAAYRAewREPLSGT----YRG-Y 232
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294 278 TMCGGPPPSSfGVTQLIVSAMSKLFPEGHKDdiYNDPKVLHKYIEAMKFAYAQR-TLLGDHDFVKGALElskNLTTPEYT 356
Cdd:COG0405 233 TVYSMPPPSQ-GIALLQILNILEGFDLAALG--PDSAEYVHLLAEAMKLAFADRdRYLGDPDFVDVPVE---GLLSPAYA 306
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294 357 QwviDRM----TDKAQSSKNYGGIAQYVPPDhgTSHVSAMDQYGNGVSATTTINRWFGAAVESSEYGILWNDEMDDFStp 432
Cdd:COG0405 307 A---ERAalidPDRATPSPRPGDPTGPESGD--TTHLSVVDRDGNAVSLTQSIYGGFGSGVVVPGTGFLLNNRGDDFS-- 379
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294 433 gmengfgFAPSETNFIEPGKRPMSSMSPMVIFDHvtKKVRMVIGGSGGSKIISALAKSIVRSLIFHDSIKKAIDAPMIHN 512
Cdd:COG0405 380 -------LDPGHPNALAPGKRPRSTMSPTIVLKD--GKPVLVFGSPGGSRIPQTVLQVLLNVLDFGMNPQEAVDAPRWHH 450
                       490       500       510       520       530
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 72000294 513 QFTPDITQLDDEFPINMKNILESEYlQKFRNTTGFEGIIQGVNVLNDGIYACG-DYRR 569
Cdd:COG0405 451 QGLPDTLELEPRFPPAVIAALRARG-HKVEVVPDWSGGAQAILRDPDGVLEGAaDPRR 507
g_glut_trans TIGR00066
gamma-glutamyltranspeptidase; Also called gamma-glutamyltranspeptidase (ggt). Some members of ...
42-568 7.92e-109

gamma-glutamyltranspeptidase; Also called gamma-glutamyltranspeptidase (ggt). Some members of this family have antibiotic synthesis or resistance activities. In the case of a cephalosporin acylase from Pseudomonas sp., the enzyme was shown to retain some gamma-glutamyltranspeptidase activity. Other, more distantly related proteins have ggt-related activities and score below the trusted cutoff. [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs]


Pssm-ID: 129176  Cd Length: 516  Bit Score: 335.58  E-value: 7.92e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294    42 SDNAACSKIGGEILRKGGNSIDASIASMFCLGVVNPQSSGIGGGFLMTYFDQKSGDCYSIDARETAPAAASRDMFLNDS- 120
Cdd:TIGR00066   5 SLHALASEIGEDILKEGGNAFDAAVAVGLALAVVEPFMTGLGGGGFMLISGKKTKDTTAIDFRERAPAKATRDMFLDKSg 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294   121 ----DGSKYGFKAAGTPGEIAGYWHIFKKFgsGKVTWKELVQPSVKLAREGHPVSPYLA-TVMKVKERHFRLFPSVKHWI 195
Cdd:TIGR00066  85 nplpGKSLTGGLAIGVPGTVAGLEAALKKY--GTLPLKDLIEPAIKLARNGFPINEALAdTLELYEEVLLTTKEDSKDIF 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294   196 NPeTNDTYQSGDLLKRPKLAKTLERLG-NSPNPvqlFYHGEMAKTLAKEFQEGGGLITEQDLANYKV--REYVNSNsndh 272
Cdd:TIGR00066 163 NP-TGKPLKEGDTLVQKDLAKSLELIAeNGPDA---FYKGDIAESIIDTLQKNGGIMTKKDLAAYDVeiRKPLSGD---- 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294   273 FRG--TLTMcggPPPSSFGVTQL-IVSAMSKL----FPEGHKDDIyndpkvlHKYIEAMKFAYAQRT-LLGDHDFVKGAL 344
Cdd:TIGR00066 235 YRGyqVYTT---PPPSSGGIHLLqALNILENFdlsqYGDGSAETY-------QLLAEAMKLSYADRSrYLGDPEFVDVPL 304
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294   345 ElskNLTTPEYTQWVIDRMTDKAQ--SSKNYGGIAQYVPPdHGTSHVSAMDQYGNGVSATTTINRWFGAAVESSEYGILW 422
Cdd:TIGR00066 305 E---ELLDKRYAKELAQSIKINKVdpKSTIYPGAYQPNEG-SQTTHFSVVDRDGNAVSLTTTINLEFGSGVHAPDTGILL 380
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294   423 NDEMDDFSTpgmengfgfAPSETNFIEPGKRPMSSMSPMVIFDHvtKKVRMVIGGSGGSKIISALAKSIVRSLIFHDSIK 502
Cdd:TIGR00066 381 NNEMDDFSL---------KPGGANAVEPNKRPLSSMAPTIVLKD--GKPDLVVGSPGGSRIITTVLQTIVRHIDYGMPLA 449
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 72000294   503 KAIDAPMIHNQFTPDITQLDDEFPINMKNILESEYLQKFRNTTGFEGIIQGVNVLNDG-IYACGDYR 568
Cdd:TIGR00066 450 EAVSEPRIHHQWLPDELRLEKGFPDDVLQLLKDMGHKVTLKEVFPMGVVQAIRVDPEGwLYGVSDPR 516
PLN02198 PLN02198
glutathione gamma-glutamylcysteinyltransferase
39-534 6.33e-93

glutathione gamma-glutamylcysteinyltransferase


Pssm-ID: 177849  Cd Length: 573  Bit Score: 296.22  E-value: 6.33e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294   39 ALTSDNAACSKIGGEILRKGGNSIDASIASMFCLGVVNPQSSGIGGGFLMTyFDQKSGDCYSIDARETAPAAASRDMFLN 118
Cdd:PLN02198  35 AVATDDGRCSVIGMNVLREGGNAIDASVAAALCLGVVSPASSGIGGGAFTL-IKLANGEEIAYDSRETAPLSATENMYGG 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294  119 DSDGSKYGFKAAGTPGEIAGYWHIFKKFGsgKVTWKELVQPSVKLAREGHPVSPYLATVMkVKERHFRLFPSVKHWINPE 198
Cdd:PLN02198 114 NVELKKKGALSVGVPGEVAGLFTAWKQHG--KLPWKRLVRPAEKLAAEGFKISKYLYMQM-NATRSDILADKGLSDLFVS 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294  199 TNDTYQSGDLLKRPKLAKTLERLgnSPNPVQLFYHGEMAKTLAKEFQEGGGLITEQDLANYKVREYVNSNSNDHFRGTLT 278
Cdd:PLN02198 191 NGELKKPGTICHNPKLALTLRLI--GEYGPKAFYNGTVGVNLVRDIQKSGGIITLKDLQSYRVKVKEPLSADILGYRVLG 268
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294  279 McggPPPSSFGVTQ-LIVSAMSKL-FPEGhkddiYNDPKVLHKYIEAMKFAYAQRTLLGDHDFVKGAlELSKNLTTPEYT 356
Cdd:PLN02198 269 M---PPPSSGGAAMmLILNILAQYgIPSG-----VSGPLGVHRLIEALKHAFAVRMNLGDPDFVDVT-KVVSDMLSPKFA 339
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294  357 QWVIDRMTD-KAQSSKNYGGIAQYVPpDHGTSHVSAMDQYGNGVSATTTINRWFGAAVESSEYGILWNDEMDDFSTPGME 435
Cdd:PLN02198 340 QDLKSKINDnKTFDPKHYGGRWNQID-DHGTSHLSIIDSERNAVSMTSTINGYFGALMLSPSTGIVLNNEMDDFSIPMKS 418
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294  436 NGFGFA--PSETNFIEPGKRPMSSMSPMVIFDhvTKKVRMVIGGSGGSKIISALAKSIVRSLIFHDSIKKAIDAPMIHNQ 513
Cdd:PLN02198 419 GGNLDVppPAPANFIRPGKRPLSSMTPTIVLK--DGKVKAAVGASGGANIIAGTTEVYLNHFFLKMDPLSSVLAPRIYHQ 496
                        490       500       510
                 ....*....|....*....|....*....|
gi 72000294  514 FTPDITQLDD---------EFPINMKNILE 534
Cdd:PLN02198 497 LIPNRASYENwttvyndhfEIPKATRVVLE 526
ggt PRK09615
gamma-glutamyltranspeptidase; Reviewed
34-572 5.09e-86

gamma-glutamyltranspeptidase; Reviewed


Pssm-ID: 181992  Cd Length: 581  Bit Score: 278.33  E-value: 5.09e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294   34 KFEKAALTSDNAACSKIGGEILRKGGNSIDASIASMFCLGVVNPQSSGIGGGFLMTyFDQKSGDCYSIDARETAPAAASR 113
Cdd:PRK09615  46 RAKQGMVASVDATATQVGVDILKQGGNAVDAAVAVGYALAVTHPQAGNLGGGGFML-LRTKNGNTTAIDFREMAPAKATR 124
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294  114 DMFLN-----DSDGSKYGFKAAGTPGEIAGYWHIFKKFGSgkVTWKELVQPSVKLAREGHPVSPYLATVMKVKERHFRLF 188
Cdd:PRK09615 125 DMFLDdqgnpDSKKSLTSHLASGTPGTVAGFSLALDKYGT--MPLNKVVQPAFKLARDGFIVNDALADDLKTYGSEVLPN 202
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294  189 PSVKHWINPETNDTYQSGDLLKRPKLAKTLERLG-NSPNPvqlFYHGEMAKTLAKEFQEGGGLITEQDLANYKVREyvNS 267
Cdd:PRK09615 203 HENSKAIFWKEGEPLKKGDKLVQANLAKSLEMIAeNGPDA---FYKGTIADQIAQEMQKNGGLITKEDLAAYKAVE--RT 277
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294  268 NSNDHFRG--TLTMcggPPPSSFGVTqlIVSAMSKLFPEGHKDDIYNDPKVLHKYIEAMKFAYAQRT-LLGDHDFVKGAL 344
Cdd:PRK09615 278 PISGDYRGyqVYSM---PPPSSGGIH--IVQILNILENFDMKKYGFGSADAMQIMAEAEKYAYADRSeYLGDPDFVKVPW 352
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294  345 ELsknLTTPEYTQWVIDRM-TDKAQSSKNY--GGIAQYvpPDHGTSHVSAMDQYGNGVSATTTINRWFGAAVESSEYGIL 421
Cdd:PRK09615 353 QA---LTNKAYAKSIADQIdINKAKPSSEIrpGKLAPY--ESNQTTHFSVVDKDGNAVAVTYTLNTTFGTGIVAGNSGIL 427
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294  422 WNDEMDDFST-PGMENGFGFAPSETNFIEPGKRPMSSMSPMVIFDHvtKKVRMVIGGSGGSKIISALAKSIVRSLIFHDS 500
Cdd:PRK09615 428 LNNQMDDFSAkPGVPNVYGLVGGDANAVGPNKRPLSSMSPTIVVKD--GKTWLVTGSPGGSRIITTVLQMVVNSIDYGMN 505
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 72000294  501 IKKAIDAPMIHNQFTPDITQLDDEFPINMKNILEseylQKFRNTTGFE--GIIQGVNVLNDG-IYACGDYRRKTD 572
Cdd:PRK09615 506 VAEATNAPRFHHQWLPDELRVEKGFSPDTLKLLE----AKGQKVALKEamGSTQSIMVGPDGeLYGASDPRSVDD 576
PLN02180 PLN02180
gamma-glutamyl transpeptidase 4
36-548 7.14e-86

gamma-glutamyl transpeptidase 4


Pssm-ID: 177836  Cd Length: 639  Bit Score: 279.64  E-value: 7.14e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294   36 EKAALTSDNAACSKIGGEILRKGGNSIDASIASMFCLGVVNPQSSGIGGGFLMTYFDQKSGDCYSIDARETAPAAASRDM 115
Cdd:PLN02180  81 ENGVVAADDARCSEIGASVLRRGGHAVDAAVAITLCIGVVNPMSSGIGGGSFLIVSSQKDSKAEAFDMRETAPLAASKDM 160
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294  116 FLNDSDGSKYGFKAAGTPGEIAGYWHIFKKFgsGKVTWKELVQPSVKLAREGHPVSPYLATVMKVKERHFRLFPSVKHwI 195
Cdd:PLN02180 161 YKNDASAKSLGALSMGVPGEIAGLYEAWKRY--GRLPWKPLFEPAIELARDGFVVHPYLGKAISSHAAMILKDPGLRS-V 237
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294  196 NPETNDTYQSGDLLKRPKLAKTLERLgnSPNPVQLFYHGEMAKTLAKEFQEGGGLITEQDLANYKVReYVNSNSNDHFrg 275
Cdd:PLN02180 238 FSRNGQVLKPGETCYNPELAQSLETI--SEQGPGAFYNGTIGEKLVKDVKKAGGIITMDDLRSYEVL-VTDAMSVDVM-- 312
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294  276 TLTMCGGPPPS----SFGVTQLIVSAMSKLFPEGHKDdiyndpKVLHKYIEAMKFAYAQRTLLGDHDFVKGALELSKNLT 351
Cdd:PLN02180 313 GYTIHGMPPPSggtlGFSMVIDILDSYSNLYTASGRE------LGLHRLIEAMKHMFAARMDLGDPEFVNITNAMNQMLS 386
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294  352 TpEYTQWVIDRMTDKAQSSKNYGGIAQYVPPDHGTSHVSAMDQYGNGVSATTTINRWFGAAVESSEYGILWNDEMDDFST 431
Cdd:PLN02180 387 K-AHAEEIQKRIFDNTTFPPEYYLNRWSQLRDQGTSHFCIVDADRNSVSMTSTVNYGFGAGVLSPSTGIVLNNEMDDFST 465
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000294  432 PGMENGFGFAPSETNFIEPGKRPMSSMSPMVIfdhvTKKVRMV--IGGSGGSKIISALAKSIVRSLIFHDSIKKAIDAPM 509
Cdd:PLN02180 466 PAEITPDMLPPAPTNFIEPNKRPLSSMTPLVI----TKDGEFVaaLGGAGGMHIIPAVLQVFLNCFVLNMKPKEAVESAR 541
                        490       500       510
                 ....*....|....*....|....*....|....*....
gi 72000294  510 IHNQFTPDITQLDDEFPINMKNILESEYLQKFRNTTGFE 548
Cdd:PLN02180 542 IYHRLIPNVVSYENFTAINGDHIGVSEDTKMFLAERGHE 580
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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