NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|17402873|ref|NP_510869|]
View 

BRCA2 and CDKN1A-interacting protein isoform C [Homo sapiens]

Protein Classification

BCIP domain-containing protein( domain architecture ID 10620558)

BCIP domain-containing protein similar to Saccharomyces cerevisiae protein BCP1 and Homo sapiens BRCA2 and CDKN1A-interacting protein (BCCIP)

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
BCCIP pfam13862
BCCIP; This family of proteins includes BRCA2 and CDKN1A-interacting protein (BCCIP) and BCP1. ...
58-256 2.83e-65

BCCIP; This family of proteins includes BRCA2 and CDKN1A-interacting protein (BCCIP) and BCP1. In fungi, BCP1 is involved in nuclear export, actin cytoskeleton organization and vesicular transport. Its homolog in human and mouse, BCCIP, may promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A/p21 and may be required for repair of DNA damage by homologous recombination in conjunction with BRCA2.


:

Pssm-ID: 464002  Cd Length: 199  Bit Score: 203.19  E-value: 2.83e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402873    58 NIEFEAYSLSDNDYDGIKKLLQQLF-LKA-PVNTAELTDLLIQQNHIGSVIKQtdvsedsndDMDEDEVFGFISLLNLTE 135
Cdd:pfam13862   3 NVDFEFFDPNPDDFHGIKNLLRQLFgLDAnLFDLSELADLILSQPTVGSVIKV---------DGEESDPYGFLSVLNLKK 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402873   136 RKGTQCVEQIQELVLRFCEKNceKSMVEQLDKFLN--DTTKPVGLLLSERFINVPPQIALPMYQQLQKELAGAHRTNKPc 213
Cdd:pfam13862  74 HKDKPCIKQLKEYLLSKAKKH--KESLKKLQKLLSssSKDKKVGLLISERLINMPPQLVPPLYKMLLEEIEWALEDKEP- 150
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 17402873   214 GKCYFYLLISKTFVEAGKNNSKKKP------SNKKKAALMFANAEEEFF 256
Cdd:pfam13862 151 YNFTHYLIISKVYKEVDSKLDEESRpkkkkkKGLDEDEIIYFHPEDEIF 199
 
Name Accession Description Interval E-value
BCCIP pfam13862
BCCIP; This family of proteins includes BRCA2 and CDKN1A-interacting protein (BCCIP) and BCP1. ...
58-256 2.83e-65

BCCIP; This family of proteins includes BRCA2 and CDKN1A-interacting protein (BCCIP) and BCP1. In fungi, BCP1 is involved in nuclear export, actin cytoskeleton organization and vesicular transport. Its homolog in human and mouse, BCCIP, may promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A/p21 and may be required for repair of DNA damage by homologous recombination in conjunction with BRCA2.


Pssm-ID: 464002  Cd Length: 199  Bit Score: 203.19  E-value: 2.83e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402873    58 NIEFEAYSLSDNDYDGIKKLLQQLF-LKA-PVNTAELTDLLIQQNHIGSVIKQtdvsedsndDMDEDEVFGFISLLNLTE 135
Cdd:pfam13862   3 NVDFEFFDPNPDDFHGIKNLLRQLFgLDAnLFDLSELADLILSQPTVGSVIKV---------DGEESDPYGFLSVLNLKK 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402873   136 RKGTQCVEQIQELVLRFCEKNceKSMVEQLDKFLN--DTTKPVGLLLSERFINVPPQIALPMYQQLQKELAGAHRTNKPc 213
Cdd:pfam13862  74 HKDKPCIKQLKEYLLSKAKKH--KESLKKLQKLLSssSKDKKVGLLISERLINMPPQLVPPLYKMLLEEIEWALEDKEP- 150
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 17402873   214 GKCYFYLLISKTFVEAGKNNSKKKP------SNKKKAALMFANAEEEFF 256
Cdd:pfam13862 151 YNFTHYLIISKVYKEVDSKLDEESRpkkkkkKGLDEDEIIYFHPEDEIF 199
 
Name Accession Description Interval E-value
BCCIP pfam13862
BCCIP; This family of proteins includes BRCA2 and CDKN1A-interacting protein (BCCIP) and BCP1. ...
58-256 2.83e-65

BCCIP; This family of proteins includes BRCA2 and CDKN1A-interacting protein (BCCIP) and BCP1. In fungi, BCP1 is involved in nuclear export, actin cytoskeleton organization and vesicular transport. Its homolog in human and mouse, BCCIP, may promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A/p21 and may be required for repair of DNA damage by homologous recombination in conjunction with BRCA2.


Pssm-ID: 464002  Cd Length: 199  Bit Score: 203.19  E-value: 2.83e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402873    58 NIEFEAYSLSDNDYDGIKKLLQQLF-LKA-PVNTAELTDLLIQQNHIGSVIKQtdvsedsndDMDEDEVFGFISLLNLTE 135
Cdd:pfam13862   3 NVDFEFFDPNPDDFHGIKNLLRQLFgLDAnLFDLSELADLILSQPTVGSVIKV---------DGEESDPYGFLSVLNLKK 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17402873   136 RKGTQCVEQIQELVLRFCEKNceKSMVEQLDKFLN--DTTKPVGLLLSERFINVPPQIALPMYQQLQKELAGAHRTNKPc 213
Cdd:pfam13862  74 HKDKPCIKQLKEYLLSKAKKH--KESLKKLQKLLSssSKDKKVGLLISERLINMPPQLVPPLYKMLLEEIEWALEDKEP- 150
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 17402873   214 GKCYFYLLISKTFVEAGKNNSKKKP------SNKKKAALMFANAEEEFF 256
Cdd:pfam13862 151 YNFTHYLIISKVYKEVDSKLDEESRpkkkkkKGLDEDEIIYFHPEDEIF 199
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH