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Conserved domains on  [gi|18104940|ref|NP_542177|]
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cystatin-9-like precursor [Homo sapiens]

Protein Classification

cystatin family protein( domain architecture ID 11249387)

cystatin family protein similar to cystatins which are a family of cysteine protease inhibitors

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 51-143 3.44e-13

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


:

Pssm-ID: 214484  Cd Length: 107  Bit Score: 61.68  E-value: 3.44e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18104940     51 VEFAVHTFNQQSKDYYAYRLGHILnSWKEQVESKTVFSMELLLGRTRCGKFEDDIDNCHFQESTELNntftCFFTISTRP 130
Cdd:smart00043  20 ADFAVAEYNKKSNDKYELRVIKVV-SAKSQVVAGTNYYLKVEVGETNCKKLSVDLENCPFLDQGEKF----CTAKVWEKP 94

                           90
                   ....*....|...
gi 18104940    131 WMTQFSLLNKTCL 143
Cdd:smart00043  95 WENKIKLVEFKCT 107
 
Name Accession Description Interval E-value
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 51-143 3.44e-13

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 61.68  E-value: 3.44e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18104940     51 VEFAVHTFNQQSKDYYAYRLGHILnSWKEQVESKTVFSMELLLGRTRCGKFEDDIDNCHFQESTELNntftCFFTISTRP 130
Cdd:smart00043  20 ADFAVAEYNKKSNDKYELRVIKVV-SAKSQVVAGTNYYLKVEVGETNCKKLSVDLENCPFLDQGEKF----CTAKVWEKP 94

                           90
                   ....*....|...
gi 18104940    131 WMTQFSLLNKTCL 143
Cdd:smart00043  95 WENKIKLVEFKCT 107
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 51-142 8.71e-09

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 50.17  E-value: 8.71e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18104940  51 VEFAVHTFNQQSKDYYaYRLGHILNSwKEQVESKTVFSMELLLGRTRCGKFEDDIDnCHFQESTELNNTFTCFFTISTRP 130
Cdd:cd00042  17 ADFAVAEYNKKSNDKY-LEFFKVLSA-KSQVVAGTNYYITVEAGDTNCKKSSVPLD-CPDCKLLEEGKKKFCTAKVWEKP 93

                        90
                ....*....|..
gi 18104940 131 WMTQFSLLNKTC 142
Cdd:cd00042  94 WENFKELLSFKC 105
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 50-131 3.69e-05

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 40.01  E-value: 3.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18104940    50 TVEFAVHTFNQQSKDYYaYRLGHILNSwKEQVESKTVFSMELLLGRTRCGKFEDDIDNCHFQESTELNNtftCFFTISTR 129
Cdd:pfam00031  16 ALDFALAEYNAKTDNYY-FELVEVKRA-KSQVVAGTNYFIKVEVGETDCSKSKKLLEDCPLLDEKWLGL---CSAQVYKV 90


                  ..
gi 18104940   130 PW 131
Cdd:pfam00031  91 PW 92
 
Name Accession Description Interval E-value
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 51-143 3.44e-13

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 61.68  E-value: 3.44e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18104940     51 VEFAVHTFNQQSKDYYAYRLGHILnSWKEQVESKTVFSMELLLGRTRCGKFEDDIDNCHFQESTELNntftCFFTISTRP 130
Cdd:smart00043  20 ADFAVAEYNKKSNDKYELRVIKVV-SAKSQVVAGTNYYLKVEVGETNCKKLSVDLENCPFLDQGEKF----CTAKVWEKP 94

                           90
                   ....*....|...
gi 18104940    131 WMTQFSLLNKTCL 143
Cdd:smart00043  95 WENKIKLVEFKCT 107
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 51-142 8.71e-09

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 50.17  E-value: 8.71e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18104940  51 VEFAVHTFNQQSKDYYaYRLGHILNSwKEQVESKTVFSMELLLGRTRCGKFEDDIDnCHFQESTELNNTFTCFFTISTRP 130
Cdd:cd00042  17 ADFAVAEYNKKSNDKY-LEFFKVLSA-KSQVVAGTNYYITVEAGDTNCKKSSVPLD-CPDCKLLEEGKKKFCTAKVWEKP 93

                        90
                ....*....|..
gi 18104940 131 WMTQFSLLNKTC 142
Cdd:cd00042  94 WENFKELLSFKC 105
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 50-131 3.69e-05

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 40.01  E-value: 3.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18104940    50 TVEFAVHTFNQQSKDYYaYRLGHILNSwKEQVESKTVFSMELLLGRTRCGKFEDDIDNCHFQESTELNNtftCFFTISTR 129
Cdd:pfam00031  16 ALDFALAEYNAKTDNYY-FELVEVKRA-KSQVVAGTNYFIKVEVGETDCSKSKKLLEDCPLLDEKWLGL---CSAQVYKV 90


                  ..
gi 18104940   130 PW 131
Cdd:pfam00031  91 PW 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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