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Conserved domains on  [gi|190684701|ref|NP_542182|]
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beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 7 precursor [Homo sapiens]

Protein Classification

core-2/I-branching beta-1,6-N-acetylglucosaminyltransferase family protein( domain architecture ID 706199)

core-2/I-branching beta-1,6-N-acetylglucosaminyltransferase family protein similar to Homo sapiens xylosyltransferase 1 and Arabidopsis thaliana beta-glucuronosyltransferase GlcAT14A/B/C

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Branch super family cl27418
Core-2/I-Branching enzyme; This is a family of two different beta-1, ...
111-374 3.40e-46

Core-2/I-Branching enzyme; This is a family of two different beta-1,6-N-acetylglucosaminyltransferase enzymes, I-branching enzyme and core-2 branching enzyme. I-branching enzyme is responsible for the production of the blood group I-antigen during embryonic development. Core-2 branching enzyme forms crucial side-chain branches in O-glycans. This is a fmmily of glycosyl-transferases that are Type II membrane proteins that are found in the endoplasmic reticulum (ER) and Golgi apparatus.


The actual alignment was detected with superfamily member pfam02485:

Pssm-ID: 452742  Cd Length: 250  Bit Score: 159.76  E-value: 3.40e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190684701  111 LAYIITIHK-ELAMFVQLLRAIYVPQNVYCIHVDEKAPMKYKTAVQTLVNCFENVFISSKTEKVAYAGFTRLQADINCMK 189
Cdd:pfam02485   1 IAFMFLTYKgDLPLLELWLRFFYHPENLYSIYVDSKAPSYFRERVRALASCFFNVRVIPKSESVDWGGPSMVAAELRLLA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190684701  190 VLVHSKFQWNYVINLCGQDFPIKTNREIIHYIrsKWSD-KNITPGVIQPLHIKSKTSQSHLEFVPKgsiyAPPNNRFKDK 268
Cdd:pfam02485  81 NLLLLDPSWDYFILLSESDIPLKTFDELYQYL--SSLNgNNSFIDSFSDPGWKGRGRYKPRILDPM----LPEIKKSKLF 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190684701  269 PPHNLTIYFGSAYYVLTRKFVEFILTDIHAKDMLQWSKDIRSPEQHYWVTL--NRLKDapgatPNAGWEGNVRAIKrkse 346
Cdd:pfam02485 155 LPTAFKWRKGSQWFVLSRAFAEYVVWDNLYYPLFKYYCDTCYPDEHYFPTLlcMSGEF-----PNTCANRTLTYVD---- 225
                         250       260
                  ....*....|....*....|....*...
gi 190684701  347 eGNVHDGCKGRYVedICVYGPGDLPWLI 374
Cdd:pfam02485 226 -WSRGGCHPKTYR--PCILGPEDLKRIR 250
 
Name Accession Description Interval E-value
Branch pfam02485
Core-2/I-Branching enzyme; This is a family of two different beta-1, ...
111-374 3.40e-46

Core-2/I-Branching enzyme; This is a family of two different beta-1,6-N-acetylglucosaminyltransferase enzymes, I-branching enzyme and core-2 branching enzyme. I-branching enzyme is responsible for the production of the blood group I-antigen during embryonic development. Core-2 branching enzyme forms crucial side-chain branches in O-glycans. This is a fmmily of glycosyl-transferases that are Type II membrane proteins that are found in the endoplasmic reticulum (ER) and Golgi apparatus.


Pssm-ID: 426795  Cd Length: 250  Bit Score: 159.76  E-value: 3.40e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190684701  111 LAYIITIHK-ELAMFVQLLRAIYVPQNVYCIHVDEKAPMKYKTAVQTLVNCFENVFISSKTEKVAYAGFTRLQADINCMK 189
Cdd:pfam02485   1 IAFMFLTYKgDLPLLELWLRFFYHPENLYSIYVDSKAPSYFRERVRALASCFFNVRVIPKSESVDWGGPSMVAAELRLLA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190684701  190 VLVHSKFQWNYVINLCGQDFPIKTNREIIHYIrsKWSD-KNITPGVIQPLHIKSKTSQSHLEFVPKgsiyAPPNNRFKDK 268
Cdd:pfam02485  81 NLLLLDPSWDYFILLSESDIPLKTFDELYQYL--SSLNgNNSFIDSFSDPGWKGRGRYKPRILDPM----LPEIKKSKLF 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190684701  269 PPHNLTIYFGSAYYVLTRKFVEFILTDIHAKDMLQWSKDIRSPEQHYWVTL--NRLKDapgatPNAGWEGNVRAIKrkse 346
Cdd:pfam02485 155 LPTAFKWRKGSQWFVLSRAFAEYVVWDNLYYPLFKYYCDTCYPDEHYFPTLlcMSGEF-----PNTCANRTLTYVD---- 225
                         250       260
                  ....*....|....*....|....*...
gi 190684701  347 eGNVHDGCKGRYVedICVYGPGDLPWLI 374
Cdd:pfam02485 226 -WSRGGCHPKTYR--PCILGPEDLKRIR 250
PLN03183 PLN03183
acetylglucosaminyltransferase family protein; Provisional
112-293 3.84e-11

acetylglucosaminyltransferase family protein; Provisional


Pssm-ID: 178725  Cd Length: 421  Bit Score: 64.49  E-value: 3.84e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190684701 112 AYIITIHK-ELAMFVQLLRAIYVPQNVYCIHVDEKAPMKYKTAVQTLVN---CFE---NVFISSKTEKVAYAGFTRLQAD 184
Cdd:PLN03183  81 AYLVSGSKgDLEKLWRTLRALYHPRNQYVVHLDLESPAEERLELASRVEndpMFSkvgNVYMITKANLVTYRGPTMVANT 160
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190684701 185 INCMKVLVHSKFQWNYVINLCGQDFPIKTNREIIH----------YI----RSKW-SDKNITPGVIQPlhiksktsqsHL 249
Cdd:PLN03183 161 LHACAILLKRSKDWDWFINLSASDYPLVTQDDLIHtfstldrnlnFIehtsQLGWkEEKRAMPLIIDP----------GL 230
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 190684701 250 EFVPKGSIY-APPNNRFkdkpPHNLTIYFGSAYYVLTRKFVEFIL 293
Cdd:PLN03183 231 YSTNKSDIYwVTPRRSL----PTAFKLFTGSAWMVLSRSFVEYCI 271
 
Name Accession Description Interval E-value
Branch pfam02485
Core-2/I-Branching enzyme; This is a family of two different beta-1, ...
111-374 3.40e-46

Core-2/I-Branching enzyme; This is a family of two different beta-1,6-N-acetylglucosaminyltransferase enzymes, I-branching enzyme and core-2 branching enzyme. I-branching enzyme is responsible for the production of the blood group I-antigen during embryonic development. Core-2 branching enzyme forms crucial side-chain branches in O-glycans. This is a fmmily of glycosyl-transferases that are Type II membrane proteins that are found in the endoplasmic reticulum (ER) and Golgi apparatus.


Pssm-ID: 426795  Cd Length: 250  Bit Score: 159.76  E-value: 3.40e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190684701  111 LAYIITIHK-ELAMFVQLLRAIYVPQNVYCIHVDEKAPMKYKTAVQTLVNCFENVFISSKTEKVAYAGFTRLQADINCMK 189
Cdd:pfam02485   1 IAFMFLTYKgDLPLLELWLRFFYHPENLYSIYVDSKAPSYFRERVRALASCFFNVRVIPKSESVDWGGPSMVAAELRLLA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190684701  190 VLVHSKFQWNYVINLCGQDFPIKTNREIIHYIrsKWSD-KNITPGVIQPLHIKSKTSQSHLEFVPKgsiyAPPNNRFKDK 268
Cdd:pfam02485  81 NLLLLDPSWDYFILLSESDIPLKTFDELYQYL--SSLNgNNSFIDSFSDPGWKGRGRYKPRILDPM----LPEIKKSKLF 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190684701  269 PPHNLTIYFGSAYYVLTRKFVEFILTDIHAKDMLQWSKDIRSPEQHYWVTL--NRLKDapgatPNAGWEGNVRAIKrkse 346
Cdd:pfam02485 155 LPTAFKWRKGSQWFVLSRAFAEYVVWDNLYYPLFKYYCDTCYPDEHYFPTLlcMSGEF-----PNTCANRTLTYVD---- 225
                         250       260
                  ....*....|....*....|....*...
gi 190684701  347 eGNVHDGCKGRYVedICVYGPGDLPWLI 374
Cdd:pfam02485 226 -WSRGGCHPKTYR--PCILGPEDLKRIR 250
PLN03183 PLN03183
acetylglucosaminyltransferase family protein; Provisional
112-293 3.84e-11

acetylglucosaminyltransferase family protein; Provisional


Pssm-ID: 178725  Cd Length: 421  Bit Score: 64.49  E-value: 3.84e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190684701 112 AYIITIHK-ELAMFVQLLRAIYVPQNVYCIHVDEKAPMKYKTAVQTLVN---CFE---NVFISSKTEKVAYAGFTRLQAD 184
Cdd:PLN03183  81 AYLVSGSKgDLEKLWRTLRALYHPRNQYVVHLDLESPAEERLELASRVEndpMFSkvgNVYMITKANLVTYRGPTMVANT 160
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190684701 185 INCMKVLVHSKFQWNYVINLCGQDFPIKTNREIIH----------YI----RSKW-SDKNITPGVIQPlhiksktsqsHL 249
Cdd:PLN03183 161 LHACAILLKRSKDWDWFINLSASDYPLVTQDDLIHtfstldrnlnFIehtsQLGWkEEKRAMPLIIDP----------GL 230
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 190684701 250 EFVPKGSIY-APPNNRFkdkpPHNLTIYFGSAYYVLTRKFVEFIL 293
Cdd:PLN03183 231 YSTNKSDIYwVTPRRSL----PTAFKLFTGSAWMVLSRSFVEYCI 271
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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