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Conserved domains on  [gi|18152787|ref|NP_542787|]
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neuralized-like protein 2 isoform 1 [Homo sapiens]

Protein Classification

SPRY domain-containing protein( domain architecture ID 10191491)

SPRY (SPla and the RYanodine receptor) domain-containing protein similar to yeast SSH4 (suppressor of SHR3 null mutation protein 4); the SPRY domain is a protein interaction module found in proteins implicated in important biological pathways, including those that regulate innate and adaptive immunity

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 25-242 1.17e-54

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


:

Pssm-ID: 293945  Cd Length: 161  Bit Score: 174.23  E-value: 1.17e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18152787  25 RFHRVHGANIRVDPSGTRATRV-ESFAHGVCFSREPLAPGQVFLVEIEEKELGWCGHLRLGLTALDPASLAPVPefSLPD 103
Cdd:cd12887   1 RFHENHGKNIRLSNDGRTATRVkASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPP--SATD 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18152787 104 LVNlgHTWVFAitrhHNRVPREGRpeaeaaapsrpptllvepylrieqfRIPRDrlvgrsrpglYSHLLDQLYElnvlpp 183
Cdd:cd12887  79 LKS--GTWILS----GSSVFKNGN-------------------------KIREN----------YGPDLDRLRV------ 111

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 18152787 184 tarRSRLGVlfcpRPDGTADMHIIINGEDMGPSARGLPaaQPLYAVVDVFASTKSVRLV 242
Cdd:cd12887 112 ---GDRVGV----MRTSDGTLHFYVNGEDQGVAASNVP--QPVYAVVDLYGQCEQVSIV 161
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 249-285 5.49e-07

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


:

Pssm-ID: 198037  Cd Length: 34  Bit Score: 45.09  E-value: 5.49e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 18152787    249 PSLQTLCRLVIQRSMvhrLAIDGLHLPKELKDFCKYE 285
Cdd:smart00969   1 RSLQHLCRLAIRRSL---GGIDKLPLPPRLKDYLLYY 34
 
Name Accession Description Interval E-value
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 25-242 1.17e-54

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 174.23  E-value: 1.17e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18152787  25 RFHRVHGANIRVDPSGTRATRV-ESFAHGVCFSREPLAPGQVFLVEIEEKELGWCGHLRLGLTALDPASLAPVPefSLPD 103
Cdd:cd12887   1 RFHENHGKNIRLSNDGRTATRVkASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPP--SATD 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18152787 104 LVNlgHTWVFAitrhHNRVPREGRpeaeaaapsrpptllvepylrieqfRIPRDrlvgrsrpglYSHLLDQLYElnvlpp 183
Cdd:cd12887  79 LKS--GTWILS----GSSVFKNGN-------------------------KIREN----------YGPDLDRLRV------ 111

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 18152787 184 tarRSRLGVlfcpRPDGTADMHIIINGEDMGPSARGLPaaQPLYAVVDVFASTKSVRLV 242
Cdd:cd12887 112 ---GDRVGV----MRTSDGTLHFYVNGEDQGVAASNVP--QPVYAVVDLYGQCEQVSIV 161
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 26-242 1.84e-36

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 127.27  E-value: 1.84e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18152787    26 FHRVHGANIRVDPSGTRATRVESFAHGVCFSREPLAPGQVFLVEIEEKELGWCGHLRLGLTALDPASLAPVpefSLPDLV 105
Cdd:pfam07177   1 FHPVHGKNVRLSNDGRTARRTNSFNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCDPATLRPK---ALPDLA 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18152787   106 NL--GHTWVFAitrhhnrvpregrpeaeaaapsrpptlLVEPYLRieqfriprdrlVGrsrpglyshlldqlyelnvlpp 183
Cdd:pfam07177  78 TDlrPGYWVVA---------------------------LSGSYLQ-----------EG---------------------- 97

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 18152787   184 tarrSRLGVLFCprPDGtaDMHIIINGEDMGPSARGLPAAQPLYAVVDVFASTKSVRLV 242
Cdd:pfam07177  98 ----DRLGFWVT--SDG--ELHFSVNGEDQGVALSGVPDSQPLWAVFDLYGQTTQVSIL 148
NEUZ smart00588
domain in neuralized proteins;
23-112 2.09e-25

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 97.38  E-value: 2.09e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18152787     23 PTRFHRVHGANIRVDPSGTRATRVES-FAHGVCFSREPLAPGQVFLVEIEEKELGWCGHLRLGLTALDPASL--APVPEF 99
Cdd:smart00588   2 PLRFHHRHGSNIRLSDSGRVARRSASdFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCDPATLrpASLPTN 81

                           90
                   ....*....|...
gi 18152787    100 SLPDLVNLGHTWV 112
Cdd:smart00588  82 ACPDLVDMSGFWA 94
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 249-285 5.49e-07

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 45.09  E-value: 5.49e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 18152787    249 PSLQTLCRLVIQRSMvhrLAIDGLHLPKELKDFCKYE 285
Cdd:smart00969   1 RSLQHLCRLAIRRSL---GGIDKLPLPPRLKDYLLYY 34
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 249-283 4.50e-06

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 42.54  E-value: 4.50e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 18152787   249 PSLQTLCRLVIQRSMVHRL--AIDGLHLPKELKDFCK 283
Cdd:pfam07525   3 RSLQHLCRLAIRRALGKRRlgAIDKLPLPPLLKDYLL 39
SOCS_SOCS_like cd03717
SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of ...
 246-284 2.28e-05

SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to cytokines. Identified as negative regulators of the cytokine-JAK-STAT pathway, they seem to play a role in many immunological and pathological processes. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. Related SOCS boxes are also present in Rab40-like proteins and insect proteins of unknown function that also contain a NEUZ (domain in neuralized proteins) domain.


Pssm-ID: 239687  Cd Length: 39  Bit Score: 40.66  E-value: 2.28e-05
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 18152787 246 YGLPSLQTLCRLVIqRSMVHRLAIDGLHLPKELKDFCKY 284
Cdd:cd03717   1 TSVRSLQHLCRFVI-RQCTRRDLIDQLPLPRRLKDYLKE 38
 
Name Accession Description Interval E-value
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 25-242 1.17e-54

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 174.23  E-value: 1.17e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18152787  25 RFHRVHGANIRVDPSGTRATRV-ESFAHGVCFSREPLAPGQVFLVEIEEKELGWCGHLRLGLTALDPASLAPVPefSLPD 103
Cdd:cd12887   1 RFHENHGKNIRLSNDGRTATRVkASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPP--SATD 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18152787 104 LVNlgHTWVFAitrhHNRVPREGRpeaeaaapsrpptllvepylrieqfRIPRDrlvgrsrpglYSHLLDQLYElnvlpp 183
Cdd:cd12887  79 LKS--GTWILS----GSSVFKNGN-------------------------KIREN----------YGPDLDRLRV------ 111

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 18152787 184 tarRSRLGVlfcpRPDGTADMHIIINGEDMGPSARGLPaaQPLYAVVDVFASTKSVRLV 242
Cdd:cd12887 112 ---GDRVGV----MRTSDGTLHFYVNGEDQGVAASNVP--QPVYAVVDLYGQCEQVSIV 161
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 26-242 1.84e-36

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 127.27  E-value: 1.84e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18152787    26 FHRVHGANIRVDPSGTRATRVESFAHGVCFSREPLAPGQVFLVEIEEKELGWCGHLRLGLTALDPASLAPVpefSLPDLV 105
Cdd:pfam07177   1 FHPVHGKNVRLSNDGRTARRTNSFNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCDPATLRPK---ALPDLA 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18152787   106 NL--GHTWVFAitrhhnrvpregrpeaeaaapsrpptlLVEPYLRieqfriprdrlVGrsrpglyshlldqlyelnvlpp 183
Cdd:pfam07177  78 TDlrPGYWVVA---------------------------LSGSYLQ-----------EG---------------------- 97

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 18152787   184 tarrSRLGVLFCprPDGtaDMHIIINGEDMGPSARGLPAAQPLYAVVDVFASTKSVRLV 242
Cdd:pfam07177  98 ----DRLGFWVT--SDG--ELHFSVNGEDQGVALSGVPDSQPLWAVFDLYGQTTQVSIL 148
NEUZ smart00588
domain in neuralized proteins;
23-112 2.09e-25

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 97.38  E-value: 2.09e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18152787     23 PTRFHRVHGANIRVDPSGTRATRVES-FAHGVCFSREPLAPGQVFLVEIEEKELGWCGHLRLGLTALDPASL--APVPEF 99
Cdd:smart00588   2 PLRFHHRHGSNIRLSDSGRVARRSASdFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCDPATLrpASLPTN 81

                           90
                   ....*....|...
gi 18152787    100 SLPDLVNLGHTWV 112
Cdd:smart00588  82 ACPDLVDMSGFWA 94
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 249-285 5.49e-07

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 45.09  E-value: 5.49e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 18152787    249 PSLQTLCRLVIQRSMvhrLAIDGLHLPKELKDFCKYE 285
Cdd:smart00969   1 RSLQHLCRLAIRRSL---GGIDKLPLPPRLKDYLLYY 34
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 249-283 4.50e-06

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 42.54  E-value: 4.50e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 18152787   249 PSLQTLCRLVIQRSMVHRL--AIDGLHLPKELKDFCK 283
Cdd:pfam07525   3 RSLQHLCRLAIRRALGKRRlgAIDKLPLPPLLKDYLL 39
SOCS_SOCS_like cd03717
SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of ...
 246-284 2.28e-05

SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to cytokines. Identified as negative regulators of the cytokine-JAK-STAT pathway, they seem to play a role in many immunological and pathological processes. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. Related SOCS boxes are also present in Rab40-like proteins and insect proteins of unknown function that also contain a NEUZ (domain in neuralized proteins) domain.


Pssm-ID: 239687  Cd Length: 39  Bit Score: 40.66  E-value: 2.28e-05
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 18152787 246 YGLPSLQTLCRLVIqRSMVHRLAIDGLHLPKELKDFCKY 284
Cdd:cd03717   1 TSVRSLQHLCRFVI-RQCTRRDLIDQLPLPRRLKDYLKE 38
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 249-285 8.35e-05

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 38.99  E-value: 8.35e-05
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 18152787 249 PSLQTLCRLVIQRSMVHRL--AIDGLHLPKELKDFCKYE 285
Cdd:cd03587   3 RSLQHLCRLAIRRCLGKRRldLIDKLPLPPRLKDYLLYK 41
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 249-285 1.81e-03

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 35.55  E-value: 1.81e-03
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 18152787 249 PSLQTLCRLVIQRSM-VHRL-AIDGLHLPKELKDFCKYE 285
Cdd:cd03716   4 RSLQHLCRLAIRRCLgRRRLeLIKKLPLPPRLKDYLLYE 42
SOCS_SOCS7 cd03741
SOCS (suppressors of cytokine signaling) box of SOCS7-like proteins. Together with CIS1, the ...
 250-284 2.48e-03

SOCS (suppressors of cytokine signaling) box of SOCS7-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS7 is important in the functioning of neuronal cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239710  Cd Length: 49  Bit Score: 35.46  E-value: 2.48e-03
                        10        20        30
                ....*....|....*....|....*....|....*
gi 18152787 250 SLQTLCRLVIqRSMVHRLAIDGLHLPKELKDFCKY 284
Cdd:cd03741   5 SLQHLCRFVI-RKLVRRDHIPALPLPRRLIDYLRE 38
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 248-284 2.63e-03

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 34.96  E-value: 2.63e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 18152787    248 LPSLQTLCRLVIqRSMVHRLAIDGLHLPKELKDFCKY 284
Cdd:smart00253   7 VPSLQHLCRFTI-RRCTRTDQIKTLPLPPKLKDYLSY 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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