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Conserved domains on  [gi|18491000|ref|NP_543028|]
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CCN family member 4 isoform 2 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TSP1_CCN pfam19035
CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in ...
 129-172 2.23e-16

CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in matricellular CCN proteins that have an alternative disulphide binding pattern compared to the canonical TSP1 domains.


:

Pssm-ID: 465952  Cd Length: 44  Bit Score: 71.21  E-value: 2.23e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 18491000   129 CIAYTSPWSPCSTSCGLGVSTRISNVNAQCWPEQESRLCNLRPC 172
Cdd:pfam19035   1 CEEQSTEWSPCSKTCGMGVSTRVSNDNAECKLVTETRLCQLRPC 44
IGFBP pfam00219
Insulin-like growth factor binding protein;
49-101 4.66e-09

Insulin-like growth factor binding protein;


:

Pssm-ID: 459717  Cd Length: 53  Bit Score: 51.56  E-value: 4.66e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 18491000    49 CKWPCE---CPPSPPRCPLGVslITDGCECCKMCAQQLGDNCTEA-AICDPhrGLYC 101
Cdd:pfam00219   1 CPPPCDperCPPPPPGCPAGV--VLDGCGCCKVCARQEGEPCGVYtPPCGK--GLRC 53
 
Name Accession Description Interval E-value
TSP1_CCN pfam19035
CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in ...
 129-172 2.23e-16

CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in matricellular CCN proteins that have an alternative disulphide binding pattern compared to the canonical TSP1 domains.


Pssm-ID: 465952  Cd Length: 44  Bit Score: 71.21  E-value: 2.23e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 18491000   129 CIAYTSPWSPCSTSCGLGVSTRISNVNAQCWPEQESRLCNLRPC 172
Cdd:pfam19035   1 CEEQSTEWSPCSKTCGMGVSTRVSNDNAECKLVTETRLCQLRPC 44
IGFBP pfam00219
Insulin-like growth factor binding protein;
49-101 4.66e-09

Insulin-like growth factor binding protein;


Pssm-ID: 459717  Cd Length: 53  Bit Score: 51.56  E-value: 4.66e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 18491000    49 CKWPCE---CPPSPPRCPLGVslITDGCECCKMCAQQLGDNCTEA-AICDPhrGLYC 101
Cdd:pfam00219   1 CPPPCDperCPPPPPGCPAGV--VLDGCGCCKVCARQEGEPCGVYtPPCGK--GLRC 53
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
 52-109 3.12e-06

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


Pssm-ID: 197525  Cd Length: 75  Bit Score: 43.99  E-value: 3.12e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 18491000     52 PCECPPSPPRCPLGVSLitDGCECCKMCAQQLGDNCT-EAAICDPhrGLYCDYSGDRPR 109
Cdd:smart00121   8 PARCPPCPPGCAELVRL--DGCGCCPVCARQEGEPCGvYTPRCAP--GLRCQPPPGEER 62
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 133-173 2.11e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 35.64  E-value: 2.11e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 18491000    133 TSPWSPCSTSCGLGVSTRI--------SNVNAQC-WPEQESRLCNLRPCD 173
Cdd:smart00209   4 WSEWSPCSVTCGGGVQTRTrsccspppQNGGGPCtGEDVETRACNEQPCP 53
 
Name Accession Description Interval E-value
TSP1_CCN pfam19035
CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in ...
 129-172 2.23e-16

CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in matricellular CCN proteins that have an alternative disulphide binding pattern compared to the canonical TSP1 domains.


Pssm-ID: 465952  Cd Length: 44  Bit Score: 71.21  E-value: 2.23e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 18491000   129 CIAYTSPWSPCSTSCGLGVSTRISNVNAQCWPEQESRLCNLRPC 172
Cdd:pfam19035   1 CEEQSTEWSPCSKTCGMGVSTRVSNDNAECKLVTETRLCQLRPC 44
IGFBP pfam00219
Insulin-like growth factor binding protein;
49-101 4.66e-09

Insulin-like growth factor binding protein;


Pssm-ID: 459717  Cd Length: 53  Bit Score: 51.56  E-value: 4.66e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 18491000    49 CKWPCE---CPPSPPRCPLGVslITDGCECCKMCAQQLGDNCTEA-AICDPhrGLYC 101
Cdd:pfam00219   1 CPPPCDperCPPPPPGCPAGV--VLDGCGCCKVCARQEGEPCGVYtPPCGK--GLRC 53
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
 52-109 3.12e-06

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


Pssm-ID: 197525  Cd Length: 75  Bit Score: 43.99  E-value: 3.12e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 18491000     52 PCECPPSPPRCPLGVSLitDGCECCKMCAQQLGDNCT-EAAICDPhrGLYCDYSGDRPR 109
Cdd:smart00121   8 PARCPPCPPGCAELVRL--DGCGCCPVCARQEGEPCGvYTPRCAP--GLRCQPPPGEER 62
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 134-172 6.97e-06

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 42.65  E-value: 6.97e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 18491000   134 SPWSPCSTSCGLGVSTRISNVNAQ-------CWPEQESRLCNLRPC 172
Cdd:pfam19028   7 SEWSECSVTCGGGVQTRTRTVIVEpqnggrpCPELLERRPCNLPPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 133-173 2.11e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 35.64  E-value: 2.11e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 18491000    133 TSPWSPCSTSCGLGVSTRI--------SNVNAQC-WPEQESRLCNLRPCD 173
Cdd:smart00209   4 WSEWSPCSVTCGGGVQTRTrsccspppQNGGGPCtGEDVETRACNEQPCP 53
TSP_1 pfam00090
Thrombospondin type 1 domain;
133-172 3.80e-03

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 34.70  E-value: 3.80e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 18491000   133 TSPWSPCSTSCGLGVSTRISNVNAQCW-------PEQESRLCNLRPC 172
Cdd:pfam00090   3 WSPWSPCSVTCGKGIQVRQRTCKSPFPggepctgDDIETQACKMDKC 49
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 135-172 6.83e-03

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 34.35  E-value: 6.83e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 18491000   135 PWSPCSTSCGLGVSTR----------ISNVNAQCWPEQ---ESRLCNLRPC 172
Cdd:pfam19030   5 PWGECSVTCGGGVQTRlvqcvqkgggSIVPDSECSAQKkppETQSCNLKPC 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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