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Conserved domains on  [gi|27477049|ref|NP_543144|]
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ankyrin repeat and SOCS box protein 17 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 251-294 1.81e-08

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


:

Pssm-ID: 239686  Cd Length: 42  Bit Score: 49.42  E-value: 1.81e-08
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 27477049 251 KDPCELLHLCRLTIRNQLLTNnmLPDGIFSLLIPARLQNYLNLE 294
Cdd:cd03716   1 STPRSLQHLCRLAIRRCLGRR--RLELIKKLPLPPRLKDYLLYE 42
Ank_2 super family cl48147
Ankyrin repeats (3 copies);
82-171 2.00e-03

Ankyrin repeats (3 copies);


The actual alignment was detected with superfamily member pfam12796:

Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 36.63  E-value: 2.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27477049    82 EVSFNLDFTEICVNTILYWvFARKGNPDFVELLLKKTKdyvQDRSCNlaliwrtftpvycpsplsGITPLFYVAQTRQSN 161
Cdd:pfam12796  18 ENGADANLQDKNGRTALHL-AAKNGHLEIVKLLLEHAD---VNLKDN------------------GRTALHYAARSGHLE 75

                          90
                  ....*....|
gi 27477049   162 IFKILLQYGI 171
Cdd:pfam12796  76 IVKLLLEKGA 85
 
Name Accession Description Interval E-value
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 251-294 1.81e-08

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 49.42  E-value: 1.81e-08
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 27477049 251 KDPCELLHLCRLTIRNQLLTNnmLPDGIFSLLIPARLQNYLNLE 294
Cdd:cd03716   1 STPRSLQHLCRLAIRRCLGRR--RLELIKKLPLPPRLKDYLLYE 42
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 253-291 4.07e-06

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 42.92  E-value: 4.07e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 27477049   253 PCELLHLCRLTIRNQLLTNnmLPDGIFSLLIPARLQNYL 291
Cdd:pfam07525   2 PRSLQHLCRLAIRRALGKR--RLGAIDKLPLPPLLKDYL 38
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 256-294 4.45e-04

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 37.00  E-value: 4.45e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 27477049    256 LLHLCRLTIRNQLltnnmlpDGIFSLLIPARLQNYLNLE 294
Cdd:smart00969   3 LQHLCRLAIRRSL-------GGIDKLPLPPRLKDYLLYY 34
Ank_2 pfam12796
Ankyrin repeats (3 copies);
82-171 2.00e-03

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 36.63  E-value: 2.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27477049    82 EVSFNLDFTEICVNTILYWvFARKGNPDFVELLLKKTKdyvQDRSCNlaliwrtftpvycpsplsGITPLFYVAQTRQSN 161
Cdd:pfam12796  18 ENGADANLQDKNGRTALHL-AAKNGHLEIVKLLLEHAD---VNLKDN------------------GRTALHYAARSGHLE 75

                          90
                  ....*....|
gi 27477049   162 IFKILLQYGI 171
Cdd:pfam12796  76 IVKLLLEKGA 85
 
Name Accession Description Interval E-value
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 251-294 1.81e-08

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 49.42  E-value: 1.81e-08
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 27477049 251 KDPCELLHLCRLTIRNQLLTNnmLPDGIFSLLIPARLQNYLNLE 294
Cdd:cd03716   1 STPRSLQHLCRLAIRRCLGRR--RLELIKKLPLPPRLKDYLLYE 42
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 253-294 2.09e-07

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 46.69  E-value: 2.09e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 27477049 253 PCELLHLCRLTIRNQLLTNNmlPDGIFSLLIPARLQNYLNLE 294
Cdd:cd03587   2 PRSLQHLCRLAIRRCLGKRR--LDLIDKLPLPPRLKDYLLYK 41
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 253-291 4.07e-06

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 42.92  E-value: 4.07e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 27477049   253 PCELLHLCRLTIRNQLLTNnmLPDGIFSLLIPARLQNYL 291
Cdd:pfam07525   2 PRSLQHLCRLAIRRALGKR--RLGAIDKLPLPPLLKDYL 38
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 256-294 4.45e-04

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 37.00  E-value: 4.45e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 27477049    256 LLHLCRLTIRNQLltnnmlpDGIFSLLIPARLQNYLNLE 294
Cdd:smart00969   3 LQHLCRLAIRRSL-------GGIDKLPLPPRLKDYLLYY 34
Ank_2 pfam12796
Ankyrin repeats (3 copies);
82-171 2.00e-03

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 36.63  E-value: 2.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27477049    82 EVSFNLDFTEICVNTILYWvFARKGNPDFVELLLKKTKdyvQDRSCNlaliwrtftpvycpsplsGITPLFYVAQTRQSN 161
Cdd:pfam12796  18 ENGADANLQDKNGRTALHL-AAKNGHLEIVKLLLEHAD---VNLKDN------------------GRTALHYAARSGHLE 75

                          90
                  ....*....|
gi 27477049   162 IFKILLQYGI 171
Cdd:pfam12796  76 IVKLLLEKGA 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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