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Conserved domains on  [gi|215598806|ref|NP_543147|]
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ankyrin repeat and SOCS box protein 10 isoform 3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
99-343 1.23e-35

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 133.54  E-value: 1.23e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215598806  99 EELTTPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPG 177
Cdd:COG0666   52 ALGALLLLAAALAGDLLVALLLLAAGADINaKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNG 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215598806 178 TLECAELLLRFGARVDGRSEEEEeTPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLlaacdvrcqsitdaeattar 257
Cdd:COG0666  132 NLEIVKLLLEAGADVNAQDNDGN-TPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPL-------------------- 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215598806 258 clqlcslllsagadadaadqdkqrplHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHcalqgpaAALAQSPEHVVRA 337
Cdd:COG0666  191 --------------------------HLAAENGHLEIVKLLLEAGADVNAKDNDGKTALD-------LAAENGNLEIVKL 237


                 ....*.
gi 215598806 338 LLNHGA 343
Cdd:COG0666  238 LLEAGA 243
SOCS super family cl02533
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 406-424 4.89e-03

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


The actual alignment was detected with superfamily member cd03723:

Pssm-ID: 470605  Cd Length: 48  Bit Score: 35.11  E-value: 4.89e-03
                         10
                 ....*....|....*....
gi 215598806 406 QPRSLQHLSRCALRSHLEG 424
Cdd:cd03723    2 TPRSLQHLCRCAIRKLLGS 20
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
99-343 1.23e-35

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 133.54  E-value: 1.23e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215598806  99 EELTTPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPG 177
Cdd:COG0666   52 ALGALLLLAAALAGDLLVALLLLAAGADINaKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNG 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215598806 178 TLECAELLLRFGARVDGRSEEEEeTPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLlaacdvrcqsitdaeattar 257
Cdd:COG0666  132 NLEIVKLLLEAGADVNAQDNDGN-TPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPL-------------------- 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215598806 258 clqlcslllsagadadaadqdkqrplHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHcalqgpaAALAQSPEHVVRA 337
Cdd:COG0666  191 --------------------------HLAAENGHLEIVKLLLEAGADVNAKDNDGKTALD-------LAAENGNLEIVKL 237


                 ....*.
gi 215598806 338 LLNHGA 343
Cdd:COG0666  238 LLEAGA 243
Ank_2 pfam12796
Ankyrin repeats (3 copies);
137-230 9.47e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 83.63  E-value: 9.47e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215598806  137 LHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFgarVDGRSEEEEETPLHVAARLGHVELA 216
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH---ADVNLKDNGRTALHYAARSGHLEIV 77

                          90
                  ....*....|....
gi 215598806  217 DLLLRRGACPDARN 230
Cdd:pfam12796  78 KLLLEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 133-319 2.36e-11

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 65.43  E-value: 2.36e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215598806 133 GRTALHeacAAGHTAC------VHVLLVAGADPNIADQDGKRPLHLC-RGPGTLECAELLLRFGARVDGRSeEEEETPLH 205
Cdd:PHA03095  47 GKTPLH---LYLHYSSekvkdiVRLLLEAGADVNAPERCGFTPLHLYlYNATTLDVIKLLIKAGADVNAKD-KVGRTPLH 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215598806 206 VAARlG---HVELADLLLRRGACPDARNAEGWTPL-----------------------LAACDVRCQSITDAEATTARCL 259
Cdd:PHA03095 123 VYLS-GfniNPKVIRLLLRKGADVNALDLYGMTPLavllksrnanvellrllidagadVYAVDDRFRSLLHHHLQSFKPR 201

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 215598806 260 QL-CSLLLSAGADADAADQDKQRPLHLA-----CRRGHaaVVELLLScGVSANTMDYGGHTPLHCA 319
Cdd:PHA03095 202 ARiVRELIRAGCDPAATDMLGNTPLHSMatgssCKRSL--VLPLLIA-GISINARNRYGQTPLHYA 264
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 133-161 7.59e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 39.49  E-value: 7.59e-05
                           10        20
                   ....*....|....*....|....*....
gi 215598806   133 GRTALHEACAAGHTACVHVLLVAGADPNI 161
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 103-237 1.43e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 41.15  E-value: 1.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215598806 103 TPLHVAASRGHTEVLRLLLrrrarpDSAPG------------GRTALHEACAAGHTACVHVLLVAGADPNIADQDGkrpL 170
Cdd:cd22192   53 TALHVAALYDNLEAAVVLM------EAAPElvnepmtsdlyqGETALHIAVVNQNLNLVRELIARGADVVSPRATG---T 123

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 215598806 171 HLCRGPGTLecaellLRFGarvdgrseeeeETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPL 237
Cdd:cd22192  124 FFRPGPKNL------IYYG-----------EHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVL 173
SOCS_ASB4_ASB18 cd03723
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members ...
 406-424 4.89e-03

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239693  Cd Length: 48  Bit Score: 35.11  E-value: 4.89e-03
                         10
                 ....*....|....*....
gi 215598806 406 QPRSLQHLSRCALRSHLEG 424
Cdd:cd03723    2 TPRSLQHLCRCAIRKLLGS 20
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
99-343 1.23e-35

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 133.54  E-value: 1.23e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215598806  99 EELTTPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPG 177
Cdd:COG0666   52 ALGALLLLAAALAGDLLVALLLLAAGADINaKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNG 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215598806 178 TLECAELLLRFGARVDGRSEEEEeTPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLlaacdvrcqsitdaeattar 257
Cdd:COG0666  132 NLEIVKLLLEAGADVNAQDNDGN-TPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPL-------------------- 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215598806 258 clqlcslllsagadadaadqdkqrplHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHcalqgpaAALAQSPEHVVRA 337
Cdd:COG0666  191 --------------------------HLAAENGHLEIVKLLLEAGADVNAKDNDGKTALD-------LAAENGNLEIVKL 237


                 ....*.
gi 215598806 338 LLNHGA 343
Cdd:COG0666  238 LLEAGA 243
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
105-343 7.55e-30

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 117.75  E-value: 7.55e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215598806 105 LHVAASRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAEL 184
Cdd:COG0666   26 LAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKL 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215598806 185 LLRFGARVDGRSEEEEeTPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLlaacdvrcqsitdaeattarclqlcsl 264
Cdd:COG0666  106 LLEAGADVNARDKDGE-TPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPL--------------------------- 157

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 215598806 265 llsagadadaadqdkqrplHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHcalqgpAAALAQSPEhVVRALLNHGA 343
Cdd:COG0666  158 -------------------HLAAANGNLEIVKLLLEAGADVNARDNDGETPLH------LAAENGHLE-IVKLLLEAGA 210
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
103-241 7.44e-27

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 109.27  E-value: 7.44e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215598806 103 TPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLEC 181
Cdd:COG0666  122 TPLHLAAYNGNLEIVKLLLEAGADVNAQdNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEI 201

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 215598806 182 AELLLRFGARVDGRSeEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAAC 241
Cdd:COG0666  202 VKLLLEAGADVNAKD-NDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAA 260
Ank_2 pfam12796
Ankyrin repeats (3 copies);
137-230 9.47e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 83.63  E-value: 9.47e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215598806  137 LHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFgarVDGRSEEEEETPLHVAARLGHVELA 216
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH---ADVNLKDNGRTALHYAARSGHLEIV 77

                          90
                  ....*....|....
gi 215598806  217 DLLLRRGACPDARN 230
Cdd:pfam12796  78 KLLLEKGADINVKD 91
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
102-237 1.02e-19

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 89.24  E-value: 1.02e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215598806 102 TTPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLE 180
Cdd:COG0666  154 NTPLHLAAANGNLEIVKLLLEAGADVNARdNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLE 233

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 215598806 181 CAELLLRFGARVDGRsEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPL 237
Cdd:COG0666  234 IVKLLLEAGADLNAK-DKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
PHA03095 PHA03095
ankyrin-like protein; Provisional
 133-319 2.36e-11

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 65.43  E-value: 2.36e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215598806 133 GRTALHeacAAGHTAC------VHVLLVAGADPNIADQDGKRPLHLC-RGPGTLECAELLLRFGARVDGRSeEEEETPLH 205
Cdd:PHA03095  47 GKTPLH---LYLHYSSekvkdiVRLLLEAGADVNAPERCGFTPLHLYlYNATTLDVIKLLIKAGADVNAKD-KVGRTPLH 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215598806 206 VAARlG---HVELADLLLRRGACPDARNAEGWTPL-----------------------LAACDVRCQSITDAEATTARCL 259
Cdd:PHA03095 123 VYLS-GfniNPKVIRLLLRKGADVNALDLYGMTPLavllksrnanvellrllidagadVYAVDDRFRSLLHHHLQSFKPR 201

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 215598806 260 QL-CSLLLSAGADADAADQDKQRPLHLA-----CRRGHaaVVELLLScGVSANTMDYGGHTPLHCA 319
Cdd:PHA03095 202 ARiVRELIRAGCDPAATDMLGNTPLHSMatgssCKRSL--VLPLLIA-GISINARNRYGQTPLHYA 264
Ank_2 pfam12796
Ankyrin repeats (3 copies);
204-343 3.35e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 59.36  E-value: 3.35e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215598806  204 LHVAARLGHVELADLLLRRGACPDARNAEGWTpllaacdvrcqsitdaeattarclqlcslllsagadadaadqdkqrPL 283
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRT----------------------------------------------AL 34

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 215598806  284 HLACRRGHAAVVELLLSCGVSANTMDygGHTPLHCalqgpaAALAQSPEhVVRALLNHGA 343
Cdd:pfam12796  35 HLAAKNGHLEIVKLLLEHADVNLKDN--GRTALHY------AARSGHLE-IVKLLLEKGA 85
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 15-208 1.56e-10

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 63.38  E-value: 1.56e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215598806  15 LGCLPSAPACRIWRPHSRPAWEPPRPSPLLCQDMALQNAlytgDLARLQElfppHSTADLLLESRAAEPRWSSHQRGLWS 94
Cdd:PTZ00322   4 LVCSVASSAFAAQLFFGTEGSRKRRAKPISFERMAAIQE----EIARIDT----HLEALEATENKDATPDHNLTTEEVID 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215598806  95 LTYEEELTTPL-HVAASrGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHL 172
Cdd:PTZ00322  76 PVVAHMLTVELcQLAAS-GDAVGARILLTGGADPNCRDyDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLEL 154

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 215598806 173 CRGPGTLECAELLLR-------FGAR-----VDGRSEEEEETPLHVAA 208
Cdd:PTZ00322 155 AEENGFREVVQLLSRhsqchfeLGANakpdsFTGKPPSLEDSPISSHH 202
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 137-225 2.48e-10

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 62.61  E-value: 2.48e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215598806 137 LHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDgRSEEEEETPLHVAARLGHVELA 216
Cdd:PTZ00322  86 LCQLAASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPT-LLDKDGKTPLELAEENGFREVV 164


                 ....*....
gi 215598806 217 DLLLRRGAC 225
Cdd:PTZ00322 165 QLLSRHSQC 173
Ank_2 pfam12796
Ankyrin repeats (3 copies);
103-163 1.49e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 54.74  E-value: 1.49e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 215598806  103 TPLHVAASRGHTEVLRLLLRRrARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIAD 163
Cdd:pfam12796  32 TALHLAAKNGHLEIVKLLLEH-ADVNLKDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 152-343 1.79e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 59.65  E-value: 1.79e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215598806 152 LLVAGADPNIADQDGKRPLHLCRGPGTLECAE---LLLRFGARVDGRsEEEEETPLHVAARLGHVE-LADLLLRRGACPD 227
Cdd:PHA03095  33 LLAAGADVNFRGEYGKTPLHLYLHYSSEKVKDivrLLLEAGADVNAP-ERCGFTPLHLYLYNATTLdVIKLLIKAGADVN 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215598806 228 ARNAEGWTPLLAacdvrcqsitdaeattarclqlcslllsagadadaadqdkqrplHLACRRGHAAVVELLLSCGVSANT 307
Cdd:PHA03095 112 AKDKVGRTPLHV--------------------------------------------YLSGFNINPKVIRLLLRKGADVNA 147

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 215598806 308 MDYGGHTPLHCALQGPAAALAqspehVVRALLNHGA 343
Cdd:PHA03095 148 LDLYGMTPLAVLLKSRNANVE-----LLRLLIDAGA 178
Ank_2 pfam12796
Ankyrin repeats (3 copies);
283-346 1.85e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 54.35  E-value: 1.85e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 215598806  283 LHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHcalqgpAAALAQSPEhVVRALLNHGAVRV 346
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALH------LAAKNGHLE-IVKLLLEHADVNL 57
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 149-343 6.60e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 54.58  E-value: 6.60e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215598806 149 VHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRsEEEEETPLHVAARLGHVELADLLLRRGACPDA 228
Cdd:PHA02874 107 IKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIE-DDNGCYPIHIAIKHNFFDIIKLLLEKGAYANV 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215598806 229 RNAEGWTPLLAAC---DVRCQS--ITDAEATTARCLQLCSlllsagadadaadqdkqrPLHLACRRGHAaVVELLLScGV 303
Cdd:PHA02874 186 KDNNGESPLHNAAeygDYACIKllIDHGNHIMNKCKNGFT------------------PLHNAIIHNRS-AIELLIN-NA 245

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 215598806 304 SANTMDYGGHTPLHCALQGPAAalaqspEHVVRALLNHGA 343
Cdd:PHA02874 246 SINDQDIDGSTPLHHAINPPCD------IDIIDILLYHKA 279
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 149-343 9.45e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 53.84  E-value: 9.45e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215598806 149 VHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDA 228
Cdd:PHA02875  51 IKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDI 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215598806 229 RNAEGWTPLLAAC---DVR----------CQSITDAEATTarclqlcslllsagadadaadqdkqrPLHLACRRGHAAVV 295
Cdd:PHA02875 131 PNTDKFSPLHLAVmmgDIKgiellidhkaCLDIEDCCGCT--------------------------PLIIAMAKGDIAIC 184

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 215598806 296 ELLLSCGVSANTMDYGGHTPLHCalqgpaAALAQSPEHVVRALLNHGA 343
Cdd:PHA02875 185 KMLLDSGANIDYFGKNGCVAALC------YAIENNKIDIVRLFIKRGA 226
Ank_5 pfam13857
Ankyrin repeats (many copies);
185-237 5.83e-07

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 46.19  E-value: 5.83e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 215598806  185 LLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPL 237
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 146-320 1.47e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 50.26  E-value: 1.47e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215598806 146 TACVHVLLVAGADPNIADQD-GKRPLHLCRGPGTLECAELLLRFGARVDgRSEEEEETPLHVAARLGHVELADLLLRRGA 224
Cdd:PHA02878 147 AEITKLLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSYGANVN-IPDKTNNSPLHHAVKHYNKPIVHILLENGA 225

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215598806 225 CPDARNAEGWTPLLAACDvRCQSITDAEATTARCLQLCSLLLSAGADadaadqdkqrPLHLACRrgHAAVVELLLSCGVS 304
Cdd:PHA02878 226 STDARDKCGNTPLHISVG-YCKDYDILKLLLEHGVDVNAKSYILGLT----------ALHSSIK--SERKLKLLLEYGAD 292

                        170
                 ....*....|....*.
gi 215598806 305 ANTMDYGGHTPLHCAL 320
Cdd:PHA02878 293 INSLNSYKLTPLSSAV 308
Ank_4 pfam13637
Ankyrin repeats (many copies);
202-241 3.22e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 44.19  E-value: 3.22e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 215598806  202 TPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAAC 241
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAA 42
PHA03095 PHA03095
ankyrin-like protein; Provisional
 133-245 3.59e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 49.25  E-value: 3.59e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215598806 133 GRTALHEACAAGHT--ACVHVLLVAGADPNIADQDGKRPLHLCRGPGTleCAELLLRF----GARVDGRSEEEEeTPLHV 206
Cdd:PHA03095 187 FRSLLHHHLQSFKPraRIVRELIRAGCDPAATDMLGNTPLHSMATGSS--CKRSLVLPlliaGISINARNRYGQ-TPLHY 263

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 215598806 207 AARLGHVELADLLLRRGACPDARNAEGWTPLLAA---CDVRC 245
Cdd:PHA03095 264 AAVFNNPRACRRLIALGADINAVSSDGNTPLSLMvrnNNGRA 305
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 103-230 5.35e-06

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 49.10  E-value: 5.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215598806 103 TPLHVAASRGHTE---VLRLLLRRRARPDSapGGRTALHEACAAGHTACVHVL--LVAGADPNIADQdgkrplHLCRGP- 176
Cdd:PLN03192 560 TPLHIAASKGYEDcvlVLLKHACNVHIRDA--NGNTALWNAISAKHHKIFRILyhFASISDPHAAGD------LLCTAAk 631

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 215598806 177 -GTLECAELLLRFGARVDGRsEEEEETPLHVAARLGHVELADLLLRRGACPDARN 230
Cdd:PLN03192 632 rNDLTAMKELLKQGLNVDSE-DHQGATALQVAMAEDHVDMVRLLIMNGADVDKAN 685
Ank_4 pfam13637
Ankyrin repeats (many copies);
133-186 7.27e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 43.03  E-value: 7.27e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 215598806  133 GRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLL 186
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 133-163 1.92e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 41.51  E-value: 1.92e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 215598806  133 GRTALHEACA-AGHTACVHVLLVAGADPNIAD 163
Cdd:pfam00023   2 GNTPLHLAAGrRGNLEIVKLLLSKGADVNARD 33
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 201-230 2.76e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 41.12  E-value: 2.76e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 215598806  201 ETPLHVAA-RLGHVELADLLLRRGACPDARN 230
Cdd:pfam00023   3 NTPLHLAAgRRGNLEIVKLLLSKGADVNARD 33
Ank_4 pfam13637
Ankyrin repeats (many copies);
102-153 3.98e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 41.11  E-value: 3.98e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 215598806  102 TTPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLL 153
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEKGADINAVDGnGETALHFAASNGNVEVLKLLL 54
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 134-343 5.04e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 45.37  E-value: 5.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215598806 134 RTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDgRSEEEEETPLHVAARLGHV 213
Cdd:PHA02875   3 QVALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPD-VKYPDIESELHDAVEEGDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215598806 214 ELADLLLRRGA-CPDARNAEGWTPLLAacdvrcqsitdaeATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHA 292
Cdd:PHA02875  82 KAVEELLDLGKfADDVFYKDGMTPLHL-------------ATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDI 148

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 215598806 293 AVVELLLSCGVSANTMDYGGHTPLhcalqgpAAALAQSPEHVVRALLNHGA 343
Cdd:PHA02875 149 KGIELLIDHKACLDIEDCCGCTPL-------IIAMAKGDIAICKMLLDSGA 192
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 133-161 7.59e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 39.49  E-value: 7.59e-05
                           10        20
                   ....*....|....*....|....*....
gi 215598806   133 GRTALHEACAAGHTACVHVLLVAGADPNI 161
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 149-309 9.93e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 44.66  E-value: 9.93e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215598806 149 VHVLLVAGADPNIADQDGKRPLHLC--RGPGTLECAELLLRFGARVDGRSEEEEeTPLHVAARLGHVEL----------- 215
Cdd:PHA03100  89 VKLLLEYGANVNAPDNNGITPLLYAisKKSNSYSIVEYLLDNGANVNIKNSDGE-NLLHLYLESNKIDLkilkllidkgv 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215598806 216 -------ADLLLRRGACPDARNAEGWTPLLAACD----------VRCQS----ITDAEATtarclqlcslllsagadada 274
Cdd:PHA03100 168 dinaknrVNYLLSYGVPINIKDVYGFTPLHYAVYnnnpefvkylLDLGAnpnlVNKYGDT-------------------- 227

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 215598806 275 adqdkqrPLHLACRRGHAAVVELLLSCGVSANTMD 309
Cdd:PHA03100 228 -------PLHIAILNNNKEIFKLLLNNGPSIKTII 255
PHA02946 PHA02946
ankyin-like protein; Provisional
 133-204 1.12e-04

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 44.27  E-value: 1.12e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 215598806 133 GRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPG--TLECAELLLRFGARVDGRSEEEEETPL 204
Cdd:PHA02946  72 GNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYLSGTDdeVIERINLLVQYGAKINNSVDEEGCGPL 145
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 133-343 1.43e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 44.28  E-value: 1.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215598806 133 GRTALHEACAAGH-TACVHVLLVAGADPNIADQDGKRPLH----LCRGPGTLECaelLLRFGARVDGRsEEEEETPLHVA 207
Cdd:PHA02876 307 GETPLYLMAKNGYdTENIRTLIMLGADVNAADRLYITPLHqastLDRNKDIVIT---LLELGANVNAR-DYCDKTPIHYA 382

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215598806 208 ARLGHVELADLLLRRGACPDARNAEGWTPL-LAACD----VRCQSITDAEATTARCLQLCSLllsagadadaadqdkqrP 282
Cdd:PHA02876 383 AVRNNVVIINTLLDYGADIEALSQKIGTALhFALCGtnpyMSVKTLIDRGANVNSKNKDLST-----------------P 445

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 215598806 283 LHLACRRG-HAAVVELLLSCGVSANTMDYGGHTPLHCALQgpaaalaqsPEHVVRALLNHGA 343
Cdd:PHA02876 446 LHYACKKNcKLDVIEMLLDNGADVNAINIQNQYPLLIALE---------YHGIVNILLHYGA 498
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 180-343 1.55e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 44.10  E-value: 1.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215598806 180 ECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNaegwtpllaacdvrcqsITDaeattarcl 259
Cdd:PHA02878 148 EITKLLLSYGADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPD-----------------KTN--------- 201

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215598806 260 qlcslllsagadadaadqdkQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALqgpAAALAQSpehVVRALL 339
Cdd:PHA02878 202 --------------------NSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISV---GYCKDYD---ILKLLL 255


                 ....
gi 215598806 340 NHGA 343
Cdd:PHA02878 256 EHGV 259
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 103-224 2.29e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 43.44  E-value: 2.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215598806 103 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTA-LHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLEC 181
Cdd:PHA02875 104 TPLHLATILKKLDIMKLLIARGADPDIPNTDKFSpLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAI 183

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 215598806 182 AELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGA 224
Cdd:PHA02875 184 CKMLLDSGANIDYFGKNGCVAALCYAIENNKIDIVRLFIKRGA 226
Ank_4 pfam13637
Ankyrin repeats (many copies);
168-220 3.23e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 38.41  E-value: 3.23e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 215598806  168 RPLHLCRGPGTLECAELLLRFGARVDgRSEEEEETPLHVAARLGHVELADLLL 220
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADIN-AVDGNGETALHFAASNGNVEVLKLLL 54
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 140-343 4.38e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 42.93  E-value: 4.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215598806 140 ACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRsEEEEETPLHVAARLGHVELADLL 219
Cdd:PLN03192 532 VASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIR-DANGNTALWNAISAKHHKIFRIL 610

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215598806 220 LRRGACPDARnaegwtpllAACDVRCqsitdaeattarclqlcslllsagadadaadqdkqrplhLACRRGHAAVVELLL 299
Cdd:PLN03192 611 YHFASISDPH---------AAGDLLC---------------------------------------TAAKRNDLTAMKELL 642

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 215598806 300 SCGVSANTMDYGGHTplhcALQgpaAALAQSPEHVVRALLNHGA 343
Cdd:PLN03192 643 KQGLNVDSEDHQGAT----ALQ---VAMAEDHVDMVRLLIMNGA 679
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 133-286 5.42e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 42.17  E-value: 5.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215598806 133 GRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEeTPLHVA-ARLG 211
Cdd:PHA02878 168 GNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGN-TPLHISvGYCK 246

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 215598806 212 HVELADLLLRRGACPDARNA-EGWTPLLAacdvrcqSITDAEATTarclqlcsLLLSAGADADAADQDKQRPLHLA 286
Cdd:PHA02878 247 DYDILKLLLEHGVDVNAKSYiLGLTALHS-------SIKSERKLK--------LLLEYGADINSLNSYKLTPLSSA 307
Ank_4 pfam13637
Ankyrin repeats (many copies);
281-322 7.10e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 37.64  E-value: 7.10e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 215598806  281 RPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQG 322
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASN 44
PHA02736 PHA02736
Viral ankyrin protein; Provisional
 163-242 8.83e-04

Viral ankyrin protein; Provisional


Pssm-ID: 165103 [Multi-domain]  Cd Length: 154  Bit Score: 39.86  E-value: 8.83e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215598806 163 DQDGKRPLHLCRGPGTLECAE---LLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRR-GACPDARNAEGWTPLL 238
Cdd:PHA02736  52 NRHGKQCVHIVSNPDKADPQEklkLLMEWGADINGKERVFGNTPLHIAVYTQNYELATWLCNQpGVNMEILNYAFKTPYY 131


                 ....
gi 215598806 239 AACD 242
Cdd:PHA02736 132 VACE 135
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 280-319 9.00e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 41.81  E-value: 9.00e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 215598806 280 QRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 319
Cdd:PTZ00322 116 RTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELA 155
PHA02946 PHA02946
ankyin-like protein; Provisional
 149-317 9.59e-04

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 41.58  E-value: 9.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215598806 149 VHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGrSEEEEETPLHVAARLGH--VELADLLLRRGA-C 225
Cdd:PHA02946  55 VEELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNA-CDKQHKTPLYYLSGTDDevIERINLLVQYGAkI 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215598806 226 PDARNAEGWTPLLAAcdvrcqsiTDAEATTARCLQLCSLLLSAGADADAADQDKqrplHLACRRGHAAVVELLLSCGVSA 305
Cdd:PHA02946 134 NNSVDEEGCGPLLAC--------TDPSERVFKKIMSIGFEARIVDKFGKNHIHR----HLMSDNPKASTISWMMKLGISP 201

                        170
                 ....*....|..
gi 215598806 306 NTMDYGGHTPLH 317
Cdd:PHA02946 202 SKPDHDGNTPLH 213
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 183-343 1.01e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 41.19  E-value: 1.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215598806 183 ELLLRFGARVDGrSEEEEETPLHVAARLGHV-----ELADLLLRRGACPDARNAEGWTPLLAACDVRCQSIT-------- 249
Cdd:PHA03100  52 KILLDNGADINS-STKNNSTPLHYLSNIKYNltdvkEIVKLLLEYGANVNAPDNNGITPLLYAISKKSNSYSiveylldn 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215598806 250 --DAEATTARCLQlcslllsagadadaadqdkqrPLHLACRRGH------------------AAVVELLLSCGVSANTMD 309
Cdd:PHA03100 131 gaNVNIKNSDGEN---------------------LLHLYLESNKidlkilkllidkgvdinaKNRVNYLLSYGVPINIKD 189

                        170       180       190
                 ....*....|....*....|....*....|....
gi 215598806 310 YGGHTPLHcalqgpAAALAQSPEhVVRALLNHGA 343
Cdd:PHA03100 190 VYGFTPLH------YAVYNNNPE-FVKYLLDLGA 216
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 282-306 1.13e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.41  E-value: 1.13e-03
                           10        20
                   ....*....|....*....|....*
gi 215598806   282 PLHLACRRGHAAVVELLLSCGVSAN 306
Cdd:smart00248   5 PLHLAAENGNLEVVKLLLDKGADIN 29
Ank_5 pfam13857
Ankyrin repeats (many copies);
279-319 1.23e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 36.94  E-value: 1.23e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 215598806  279 KQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 319
Cdd:pfam13857  16 GYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 202-228 1.25e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.03  E-value: 1.25e-03
                           10        20
                   ....*....|....*....|....*..
gi 215598806   202 TPLHVAARLGHVELADLLLRRGACPDA 228
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADINA 30
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 103-237 1.43e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 41.15  E-value: 1.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215598806 103 TPLHVAASRGHTEVLRLLLrrrarpDSAPG------------GRTALHEACAAGHTACVHVLLVAGADPNIADQDGkrpL 170
Cdd:cd22192   53 TALHVAALYDNLEAAVVLM------EAAPElvnepmtsdlyqGETALHIAVVNQNLNLVRELIARGADVVSPRATG---T 123

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 215598806 171 HLCRGPGTLecaellLRFGarvdgrseeeeETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPL 237
Cdd:cd22192  124 FFRPGPKNL------IYYG-----------EHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVL 173
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 134-343 1.95e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 40.82  E-value: 1.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215598806 134 RTALHEACAAGHTACVHVLLVAGADPNIADQDG---------------------------KRPLHLCRGPGT--LECAEL 184
Cdd:PHA02876 179 ITPIHYAAERGNAKMVNLLLSYGADVNIIALDDlsvlecavdsknidtikaiidnrsninKNDLSLLKAIRNedLETSLL 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215598806 185 LLRFGARVDGrSEEEEETPLHVAARLGHV-ELADLLLRRGACPDARNAEGWTPL----------------------LAAC 241
Cdd:PHA02876 259 LYDAGFSVNS-IDDCKNTPLHHASQAPSLsRLVPKLLERGADVNAKNIKGETPLylmakngydtenirtlimlgadVNAA 337

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215598806 242 DVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQ 321
Cdd:PHA02876 338 DRLYITPLHQASTLDRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALC 417

                        250       260
                 ....*....|....*....|..
gi 215598806 322 GpaaalaQSPEHVVRALLNHGA 343
Cdd:PHA02876 418 G------TNPYMSVKTLIDRGA 433
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 201-224 1.98e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 35.70  E-value: 1.98e-03
                          10        20
                  ....*....|....*....|....
gi 215598806  201 ETPLHVAARLGHVELADLLLRRGA 224
Cdd:pfam13606   3 NTPLHLAARNGRLEIVKLLLENGA 26
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 133-161 2.88e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 35.31  E-value: 2.88e-03
                          10        20
                  ....*....|....*....|....*....
gi 215598806  133 GRTALHEACAAGHTACVHVLLVAGADPNI 161
Cdd:pfam13606   2 GNTPLHLAARNGRLEIVKLLLENGADINA 30
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 282-307 3.09e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 34.93  E-value: 3.09e-03
                          10        20
                  ....*....|....*....|....*.
gi 215598806  282 PLHLACRRGHAAVVELLLSCGVSANT 307
Cdd:pfam13606   5 PLHLAARNGRLEIVKLLLENGADINA 30
SOCS_ASB4_ASB18 cd03723
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members ...
 406-424 4.89e-03

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239693  Cd Length: 48  Bit Score: 35.11  E-value: 4.89e-03
                         10
                 ....*....|....*....
gi 215598806 406 QPRSLQHLSRCALRSHLEG 424
Cdd:cd03723    2 TPRSLQHLCRCAIRKLLGS 20
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 282-309 4.96e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 34.57  E-value: 4.96e-03
                          10        20
                  ....*....|....*....|....*....
gi 215598806  282 PLHLAC-RRGHAAVVELLLSCGVSANTMD 309
Cdd:pfam00023   5 PLHLAAgRRGNLEIVKLLLSKGADVNARD 33
Ank_5 pfam13857
Ankyrin repeats (many copies);
132-173 5.96e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 35.01  E-value: 5.96e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 215598806  132 GGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLC 173
Cdd:pfam13857  15 EGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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