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Conserved domains on  [gi|2047705760|ref|NP_543175|]
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elongator complex protein 1 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IKI3 pfam04762
IKI3 family; Members of this family are components of the elongator multi-subunit component of ...
 1-953 0e+00

IKI3 family; Members of this family are components of the elongator multi-subunit component of a novel RNA polymerase II holoenzyme for transcriptional elongation. This region contains WD40 like repeats.


:

Pssm-ID: 428111 [Multi-domain]  Cd Length: 933  Bit Score: 1112.40  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760    1 MRNLKLHQTLEFRDIQAPGKPqcfclRAEQGTV-LIGSERGLTEVDPVKKEVKTEISLVAEGF-----------LPEDGS 68
Cdd:pfam04762    1 MRNLKVLSHGAFKPVSGTDPD-----LTLLASAfDTTSDSITFVLGPTESEGAIEVQQFMKDGqvsvlasfpapLPVGPD 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760   69 GCIVGIQDLLDQESVCVATASGDVIVC----NVSTQQLECVGNVASGISVMSWSPDQELLLLATAQQTLIMMTRDYEVIT 144
Cdd:pfam04762   76 DKILSFQHLADSESLCFASASGDIILVtydpDPETTVVEIVGSIDSGITAAAWSPDEELLALVTGEGTVLLMTRDFEPIS 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760  145 EQQIHQDDFGEGKFITVGWGSKDTQFHGSEGRPI-------TFPVQMHESALSWDDHRPQITWRGDGQFFAVSVVCSQTG 217
Cdd:pfam04762  156 ETSLDPDDLKISKHVSVGWGKKETQFHGKGAKAAerplrdpTMPEKVDEKLSSLDDHRVTISWRGDGEYFAVSSIEPETG 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760  218 -ARKIRVWNREFALQSTSESVPGLGPSLAWKPSGSLIASTQDKPNQQDVVFFEKNGLLHGYFTLPFLKDEVKVNDLLWNA 296
Cdd:pfam04762  236 sRRAIRVWSREGALDSVSEPVDGLEGSLSWRPSGSLIASIQRKDDRLDVVFFERNGLRHGEFTLRLNPAEEKVQSLAWNS 315

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760  297 DSSVLAVWLEDLpkegsstlksyVQLWTVGNYHWYLKQSLPFSTTGKNQIVSLLWDPVTPGRLHVLCQGWRYLCCDWHWT 376
Cdd:pfam04762  316 DSEVLAVVLEDR-----------VQLWTTGNYHWYLKQELYYPQSASLAGVFLKWHPEKPLTLMVGTSGGQILVYDFAWK 384

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760  377 TDRSSGNSADDLANVAVIDGNKVLVTVFQRTVTPPPMCTYRLLIPHPVNQVMFSAhLGNDLAVLDASNQISVYKCDDKPD 456
Cdd:pfam04762  385 TARGPTSSPNDNGTVAVIDGSTLLLTPFSLANVPPPMSARELELPANVNDVAFSK-SNSKLAALTSDGDISISVLSLAPM 463

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760  457 MDStvklgavggtgfkvplRTPHLEKRYRIQFGNKEEEEdVSPLQFRFLTWIEGDAFLAISHShsspqSIIHHLTMAgsE 536
Cdd:pfam04762  464 KAG----------------AHPKLVSEFSKNEIANSDFE-TALDSLRQLAFINDSTLLVLSDS-----DNLSEILLV--D 519

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760  537 GDEEQGQLNVSSSVTVDGVVIGLCCCSKTKSsAVQLADGQVLKYlwespSSAVEPWKNSegrPVRFARPCTQMEAAAIGG 616
Cdd:pfam04762  520 IDDISNPLLVSSSTSLEKIVLAKSSNDYSHV-VVETSDGKVHEG-----SLSAEGELLE---ITKFPQLCRDFRVVRVHN 590

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760  617 EE---CVLGLTDRCRFFINDTEVASNITSFAVCDDFLLVTTHSHTCQCFSLSgASLKMLQAGLCGSQVPSGEILRKVERG 693
Cdd:pfam04762  591 EGmkgVAFGLTSNGKLYANGRLLASNVTSFAVTDSHLLFTTAQHLLKFVHLN-SSVKDLEVVEDDREESHDERIRQIERG 669

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760  694 SRIVTVVPQDTKLILQMPRGNLEVVHHRALVLAQIRKWLDKLMFKEAFECMRKLRINLNLIHDHNPKVFLENVETFIKQI 773
Cdd:pfam04762  670 SRLVTVVPSKASVVLQMPRGNLETIYPRILVLAGIRKAIDAKRYKDAFLTCRTHRIDLNILHDYDPELFLQNVELFVDQI 749

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760  774 DSVNHLNLFFTELKEEDVTKTMYPPPVT---------KSVQVSTNPDGKKVDLICDAMRVAMETINPRKFCLSILTSHVK 844
Cdd:pfam04762  750 NKVDYLDLFLSCLKEEDVTKTMYKDTLSlppptsmppYNKKKSFDPKDSKVNKVCDAILKALEPEYSDKYLLTILTAYAC 829

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760  845 KTTPELDIVLQKVHELQGKipfepESVSAEEALKYLLLLVDVNELFNHSLGTYDFDLVLMVAEKSQKDPKEYLPFLNTLK 924
Cdd:pfam04762  830 KNPPNLEAALQLIASLREE-----DEEQAEEALKHLCFLVDVNKLYDVALGLYDLKLALLVAQKSQKDPKEYLPFLQELQ 904

                          970       980
                   ....*....|....*....|....*....
gi 2047705760  925 KMETNYQRFTIDKYLKRYEKALGHLSKCG 953
Cdd:pfam04762  905 KMEELRRKFLIDDYLKRYEKALGHLVEAG 933
TPR super family cl33886
Tetratricopeptide (TPR) repeat [General function prediction only];
939-1100 3.30e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


The actual alignment was detected with superfamily member COG0457:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 40.76  E-value: 3.30e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760  939 LKRYEKALGHLSKC---GPEYFtECLNLI----KDKNLYKEALKLYRpdspqyQAVSVAYGEHLVQEHLyepaGLVFARC 1011
Cdd:COG0457     55 LGRYEEALADYEQAlelDPDDA-EALNNLglalQALGRYEEALEDYD------KALELDPDDAEALYNL----GLALLEL 123

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760 1012 GAHEKALEAFlacgswQQALCMaaqlqmaKDKVAGLARTLAGKLVEQRKHSEAATVLEQYAQDYEEAVLLLLEGSAWEEA 1091
Cdd:COG0457    124 GRYDEAIEAY------ERALEL-------DPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALAL 190


                   ....*....
gi 2047705760 1092 LRLVYKYDR 1100
Cdd:COG0457    191 AAAEVLLAL 199
 
Name Accession Description Interval E-value
IKI3 pfam04762
IKI3 family; Members of this family are components of the elongator multi-subunit component of ...
 1-953 0e+00

IKI3 family; Members of this family are components of the elongator multi-subunit component of a novel RNA polymerase II holoenzyme for transcriptional elongation. This region contains WD40 like repeats.


Pssm-ID: 428111 [Multi-domain]  Cd Length: 933  Bit Score: 1112.40  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760    1 MRNLKLHQTLEFRDIQAPGKPqcfclRAEQGTV-LIGSERGLTEVDPVKKEVKTEISLVAEGF-----------LPEDGS 68
Cdd:pfam04762    1 MRNLKVLSHGAFKPVSGTDPD-----LTLLASAfDTTSDSITFVLGPTESEGAIEVQQFMKDGqvsvlasfpapLPVGPD 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760   69 GCIVGIQDLLDQESVCVATASGDVIVC----NVSTQQLECVGNVASGISVMSWSPDQELLLLATAQQTLIMMTRDYEVIT 144
Cdd:pfam04762   76 DKILSFQHLADSESLCFASASGDIILVtydpDPETTVVEIVGSIDSGITAAAWSPDEELLALVTGEGTVLLMTRDFEPIS 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760  145 EQQIHQDDFGEGKFITVGWGSKDTQFHGSEGRPI-------TFPVQMHESALSWDDHRPQITWRGDGQFFAVSVVCSQTG 217
Cdd:pfam04762  156 ETSLDPDDLKISKHVSVGWGKKETQFHGKGAKAAerplrdpTMPEKVDEKLSSLDDHRVTISWRGDGEYFAVSSIEPETG 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760  218 -ARKIRVWNREFALQSTSESVPGLGPSLAWKPSGSLIASTQDKPNQQDVVFFEKNGLLHGYFTLPFLKDEVKVNDLLWNA 296
Cdd:pfam04762  236 sRRAIRVWSREGALDSVSEPVDGLEGSLSWRPSGSLIASIQRKDDRLDVVFFERNGLRHGEFTLRLNPAEEKVQSLAWNS 315

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760  297 DSSVLAVWLEDLpkegsstlksyVQLWTVGNYHWYLKQSLPFSTTGKNQIVSLLWDPVTPGRLHVLCQGWRYLCCDWHWT 376
Cdd:pfam04762  316 DSEVLAVVLEDR-----------VQLWTTGNYHWYLKQELYYPQSASLAGVFLKWHPEKPLTLMVGTSGGQILVYDFAWK 384

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760  377 TDRSSGNSADDLANVAVIDGNKVLVTVFQRTVTPPPMCTYRLLIPHPVNQVMFSAhLGNDLAVLDASNQISVYKCDDKPD 456
Cdd:pfam04762  385 TARGPTSSPNDNGTVAVIDGSTLLLTPFSLANVPPPMSARELELPANVNDVAFSK-SNSKLAALTSDGDISISVLSLAPM 463

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760  457 MDStvklgavggtgfkvplRTPHLEKRYRIQFGNKEEEEdVSPLQFRFLTWIEGDAFLAISHShsspqSIIHHLTMAgsE 536
Cdd:pfam04762  464 KAG----------------AHPKLVSEFSKNEIANSDFE-TALDSLRQLAFINDSTLLVLSDS-----DNLSEILLV--D 519

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760  537 GDEEQGQLNVSSSVTVDGVVIGLCCCSKTKSsAVQLADGQVLKYlwespSSAVEPWKNSegrPVRFARPCTQMEAAAIGG 616
Cdd:pfam04762  520 IDDISNPLLVSSSTSLEKIVLAKSSNDYSHV-VVETSDGKVHEG-----SLSAEGELLE---ITKFPQLCRDFRVVRVHN 590

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760  617 EE---CVLGLTDRCRFFINDTEVASNITSFAVCDDFLLVTTHSHTCQCFSLSgASLKMLQAGLCGSQVPSGEILRKVERG 693
Cdd:pfam04762  591 EGmkgVAFGLTSNGKLYANGRLLASNVTSFAVTDSHLLFTTAQHLLKFVHLN-SSVKDLEVVEDDREESHDERIRQIERG 669

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760  694 SRIVTVVPQDTKLILQMPRGNLEVVHHRALVLAQIRKWLDKLMFKEAFECMRKLRINLNLIHDHNPKVFLENVETFIKQI 773
Cdd:pfam04762  670 SRLVTVVPSKASVVLQMPRGNLETIYPRILVLAGIRKAIDAKRYKDAFLTCRTHRIDLNILHDYDPELFLQNVELFVDQI 749

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760  774 DSVNHLNLFFTELKEEDVTKTMYPPPVT---------KSVQVSTNPDGKKVDLICDAMRVAMETINPRKFCLSILTSHVK 844
Cdd:pfam04762  750 NKVDYLDLFLSCLKEEDVTKTMYKDTLSlppptsmppYNKKKSFDPKDSKVNKVCDAILKALEPEYSDKYLLTILTAYAC 829

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760  845 KTTPELDIVLQKVHELQGKipfepESVSAEEALKYLLLLVDVNELFNHSLGTYDFDLVLMVAEKSQKDPKEYLPFLNTLK 924
Cdd:pfam04762  830 KNPPNLEAALQLIASLREE-----DEEQAEEALKHLCFLVDVNKLYDVALGLYDLKLALLVAQKSQKDPKEYLPFLQELQ 904

                          970       980
                   ....*....|....*....|....*....
gi 2047705760  925 KMETNYQRFTIDKYLKRYEKALGHLSKCG 953
Cdd:pfam04762  905 KMEELRRKFLIDDYLKRYEKALGHLVEAG 933
COG5290 COG5290
IkappaB kinase complex, IKAP component [Transcription];
71-1275 6.50e-159

IkappaB kinase complex, IKAP component [Transcription];


Pssm-ID: 227610 [Multi-domain]  Cd Length: 1243  Bit Score: 510.70  E-value: 6.50e-159
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760   71 IVGIQDLLDQESVCVATASGDVI-VCNVSTQQ---LECVGNVASGISVMSWSPDQELLLLATAQQTLIMMTRDYEVITEQ 146
Cdd:COG5290     70 LLSFKHFHVLTFEYFLIDEGDIIhLVNDPTPAeleMEIVGKVSNGIVAASWSADEKTWCVVTSTREILLFDKYFDPISEY 149

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760  147 QIHQDDFGE-GKFITVGWGSKDTQFHG----SEGRPITFPVQMHESALS-WDDHRPQITWRGDGQFFAVSVVcSQTGARK 220
Cdd:COG5290    150 HLKKSDLVEfGKHIRVGWGKKETQFRGkgarAQLRDPTMPYMVDYGDLFaVDTNKKIIFWRGDTEYNLVGRS-EERPRRA 228

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760  221 IRVWNREFALQSTSESVPGLGPSLAWKPSGSLIASTQDKP--NQQDVVFFEKNGLLHGYFTLPFLKDEvKVNDLLWNADS 298
Cdd:COG5290    229 FRVYSREGQLDSASEPVTGMEHQLSWKPQGSKYATIGTDGcsTSESVIFFERNGLRHGEFDLRVGCDE-KAFLENWNLLS 307

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760  299 SVLAVWLEDLpkegsstlksyVQLWTVGNYHWYLKQSLPFSttgknQIVSLLWDPVTPGRLhVLCQGWRYLCCDWHWTTD 378
Cdd:COG5290    308 TVLAVAEGNL-----------LKLWTTKNYHWYLKVERQIP-----GISYVKWHPEEKNTL-LFRDGERILRVFFSEKKT 370

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760  379 RSSGNSADDLANVAVIDGNKVLVTVFQRTVTPPPMCTYRLLIPHpvNQVMFSAHLGNDLAVLDASNQISVYKCDDKPDMD 458
Cdd:COG5290    371 HHGSEYPFDNGTSYVIDGSYMLYTPLSLKNLPPPMFSVRVGFDT--NVVDVFPSFAEKKGAALLRDRLIMFRWDSEEFIN 448

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760  459 stvklgavggtgfkvplrtphlekryriQFGNKEEEEDVSPLQFRFLTWIEGDAFLAISHSHSSPQSIIhhltmagSEGD 538
Cdd:COG5290    449 ----------------------------KRTEFLESEFDSIVLFDGFLVLKSGHVFLLKDTNNESDTYI-------TRNG 493

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760  539 EEQGQLNVSSSVTVDGVVIGLCCCSKTKssAVQLADGQVLKYLWESPSSAVepwknsegrpVRFARPCTQMEAAAIGGEE 618
Cdd:COG5290    494 DVDERKKRGTVETRRTSTLVHQLCQTLL--RYGTCVGVVKHYNFEEKLYEL----------LKFPNGVIDFSVDPVHSTL 561

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760  619 CVLGLTDRCRFFINDTEVASNITSFAVCDDFLLVTTHSHTCQcFSLSGASLKMLQAGLCGSQVPSGEILRKVERGSRIVT 698
Cdd:COG5290    562 VAIGITDIGQLFALQVLLKKSVFSHNGTKLFVLFTTTENILS-FVHLESTFKPLITVEEGTVRFFDERKRSVERGSHKVE 640

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760  699 VVPQDTKLILQMPRGNLEVVHHRALVLAQIRKWLDKLMFKEAFECMRKLRINLNLIHDHNPKVFLENVETFIKQIDSVNH 778
Cdd:COG5290    641 LLPSKDFVVLQVTRGNLETIYPRIMVLAFVRKLIAAKKYKDAFDVCRTHRVPLGILLDYDPELFIENLEVFVTECRRVDY 720

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760  779 LNLFFTELKEEDVTKTMYpPPVTKSVQV--STNPDGKKVDLICDAMR-VAMETINPRKFCLSILTSHVKKTTPELDIVLQ 855
Cdd:COG5290    721 LSLFSEALQRDDVTKTDY-SFISKSEQArrFRKVFDLKVNLECKDTReHLESLIYNDESIQTIITAYLIGNPGNGKAALM 799

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760  856 KVHELqgkipfEPESVSAEEALKYLLLLVDVNELFNHSLGTYDFDLVLMVAEKSQKDPKEYLPFLNTLKKMETNYQRFTI 935
Cdd:COG5290    800 RISPL------SRCSESLDEDVKNLCFLRDVNFFNEFALSLYDKSLALLIAQLSQKDPREYLPFLVERQDLEALRRKFSI 873

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760  936 DKYLKRYEKALGHLSKCgPEYFTECLNLIKDKNLYKEALKLYRPDSPQYQAVSVAYGEHLVQEHLYEPAGLVFARCGAHE 1015
Cdd:COG5290    874 DNYLSIYESALGHLNED-LNVIREVMKYICRHDLYDFLLLLYRYDGELQKFKINIFAGNLVDNLYHISAAKAYEVEGKYI 952

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760 1016 KALEAFLACGSWQQalCMAAQLQMAKDKVAGLARTLAGKL-VEQRKHSEAATVLEQYAQDYEEAVLLLLEGSAWEEALRL 1094
Cdd:COG5290    953 EAHGAYDSALMWRE--CGSISTQEKGYEFNLCAELLPSDLlVEFRKAGDAEKILLTYLENLYEAVAMDCKGSEYREAFCE 1030

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760 1095 VYKYDRVDIIETSVKPSILE----AQKNYMDF---LDSQTatfirhkNRLKVVRELKSQAPRVHVDHEVAHGRETDLFSE 1167
Cdd:COG5290   1031 AMVSRLVESEKHYEAGQLGEefggKPELAADEyvqIKSQG-------DRLRVLRDKKCEMPEAREILREELLTLDDVSEA 1103

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760 1168 TSSIRSGSEMSGRYSHSN--SRISARSSKNRRKAERKKHSLKEGSPLEGLALLEALSEVVQSIEKLKDEVHAILKVLFLF 1245
Cdd:COG5290   1104 FVKYSTRLSALTEYTKDEcmSKTSRSTTKNMRRGERKRARGKKGTRYEEEYLVSSIRRLILRLVGWRPETERLVEILKRF 1183

                         1210      1220      1230
                   ....*....|....*....|....*....|
gi 2047705760 1246 EFEEQARELQRAFESTLQLMGTALPDIWTL 1275
Cdd:COG5290   1184 NMEEQARAHQTNFDEVGRAIKTEVDSIFSV 1213
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
939-1100 3.30e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 40.76  E-value: 3.30e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760  939 LKRYEKALGHLSKC---GPEYFtECLNLI----KDKNLYKEALKLYRpdspqyQAVSVAYGEHLVQEHLyepaGLVFARC 1011
Cdd:COG0457     55 LGRYEEALADYEQAlelDPDDA-EALNNLglalQALGRYEEALEDYD------KALELDPDDAEALYNL----GLALLEL 123

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760 1012 GAHEKALEAFlacgswQQALCMaaqlqmaKDKVAGLARTLAGKLVEQRKHSEAATVLEQYAQDYEEAVLLLLEGSAWEEA 1091
Cdd:COG0457    124 GRYDEAIEAY------ERALEL-------DPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALAL 190


                   ....*....
gi 2047705760 1092 LRLVYKYDR 1100
Cdd:COG0457    191 AAAEVLLAL 199
 
Name Accession Description Interval E-value
IKI3 pfam04762
IKI3 family; Members of this family are components of the elongator multi-subunit component of ...
 1-953 0e+00

IKI3 family; Members of this family are components of the elongator multi-subunit component of a novel RNA polymerase II holoenzyme for transcriptional elongation. This region contains WD40 like repeats.


Pssm-ID: 428111 [Multi-domain]  Cd Length: 933  Bit Score: 1112.40  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760    1 MRNLKLHQTLEFRDIQAPGKPqcfclRAEQGTV-LIGSERGLTEVDPVKKEVKTEISLVAEGF-----------LPEDGS 68
Cdd:pfam04762    1 MRNLKVLSHGAFKPVSGTDPD-----LTLLASAfDTTSDSITFVLGPTESEGAIEVQQFMKDGqvsvlasfpapLPVGPD 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760   69 GCIVGIQDLLDQESVCVATASGDVIVC----NVSTQQLECVGNVASGISVMSWSPDQELLLLATAQQTLIMMTRDYEVIT 144
Cdd:pfam04762   76 DKILSFQHLADSESLCFASASGDIILVtydpDPETTVVEIVGSIDSGITAAAWSPDEELLALVTGEGTVLLMTRDFEPIS 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760  145 EQQIHQDDFGEGKFITVGWGSKDTQFHGSEGRPI-------TFPVQMHESALSWDDHRPQITWRGDGQFFAVSVVCSQTG 217
Cdd:pfam04762  156 ETSLDPDDLKISKHVSVGWGKKETQFHGKGAKAAerplrdpTMPEKVDEKLSSLDDHRVTISWRGDGEYFAVSSIEPETG 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760  218 -ARKIRVWNREFALQSTSESVPGLGPSLAWKPSGSLIASTQDKPNQQDVVFFEKNGLLHGYFTLPFLKDEVKVNDLLWNA 296
Cdd:pfam04762  236 sRRAIRVWSREGALDSVSEPVDGLEGSLSWRPSGSLIASIQRKDDRLDVVFFERNGLRHGEFTLRLNPAEEKVQSLAWNS 315

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760  297 DSSVLAVWLEDLpkegsstlksyVQLWTVGNYHWYLKQSLPFSTTGKNQIVSLLWDPVTPGRLHVLCQGWRYLCCDWHWT 376
Cdd:pfam04762  316 DSEVLAVVLEDR-----------VQLWTTGNYHWYLKQELYYPQSASLAGVFLKWHPEKPLTLMVGTSGGQILVYDFAWK 384

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760  377 TDRSSGNSADDLANVAVIDGNKVLVTVFQRTVTPPPMCTYRLLIPHPVNQVMFSAhLGNDLAVLDASNQISVYKCDDKPD 456
Cdd:pfam04762  385 TARGPTSSPNDNGTVAVIDGSTLLLTPFSLANVPPPMSARELELPANVNDVAFSK-SNSKLAALTSDGDISISVLSLAPM 463

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760  457 MDStvklgavggtgfkvplRTPHLEKRYRIQFGNKEEEEdVSPLQFRFLTWIEGDAFLAISHShsspqSIIHHLTMAgsE 536
Cdd:pfam04762  464 KAG----------------AHPKLVSEFSKNEIANSDFE-TALDSLRQLAFINDSTLLVLSDS-----DNLSEILLV--D 519

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760  537 GDEEQGQLNVSSSVTVDGVVIGLCCCSKTKSsAVQLADGQVLKYlwespSSAVEPWKNSegrPVRFARPCTQMEAAAIGG 616
Cdd:pfam04762  520 IDDISNPLLVSSSTSLEKIVLAKSSNDYSHV-VVETSDGKVHEG-----SLSAEGELLE---ITKFPQLCRDFRVVRVHN 590

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760  617 EE---CVLGLTDRCRFFINDTEVASNITSFAVCDDFLLVTTHSHTCQCFSLSgASLKMLQAGLCGSQVPSGEILRKVERG 693
Cdd:pfam04762  591 EGmkgVAFGLTSNGKLYANGRLLASNVTSFAVTDSHLLFTTAQHLLKFVHLN-SSVKDLEVVEDDREESHDERIRQIERG 669

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760  694 SRIVTVVPQDTKLILQMPRGNLEVVHHRALVLAQIRKWLDKLMFKEAFECMRKLRINLNLIHDHNPKVFLENVETFIKQI 773
Cdd:pfam04762  670 SRLVTVVPSKASVVLQMPRGNLETIYPRILVLAGIRKAIDAKRYKDAFLTCRTHRIDLNILHDYDPELFLQNVELFVDQI 749

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760  774 DSVNHLNLFFTELKEEDVTKTMYPPPVT---------KSVQVSTNPDGKKVDLICDAMRVAMETINPRKFCLSILTSHVK 844
Cdd:pfam04762  750 NKVDYLDLFLSCLKEEDVTKTMYKDTLSlppptsmppYNKKKSFDPKDSKVNKVCDAILKALEPEYSDKYLLTILTAYAC 829

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760  845 KTTPELDIVLQKVHELQGKipfepESVSAEEALKYLLLLVDVNELFNHSLGTYDFDLVLMVAEKSQKDPKEYLPFLNTLK 924
Cdd:pfam04762  830 KNPPNLEAALQLIASLREE-----DEEQAEEALKHLCFLVDVNKLYDVALGLYDLKLALLVAQKSQKDPKEYLPFLQELQ 904

                          970       980
                   ....*....|....*....|....*....
gi 2047705760  925 KMETNYQRFTIDKYLKRYEKALGHLSKCG 953
Cdd:pfam04762  905 KMEELRRKFLIDDYLKRYEKALGHLVEAG 933
COG5290 COG5290
IkappaB kinase complex, IKAP component [Transcription];
71-1275 6.50e-159

IkappaB kinase complex, IKAP component [Transcription];


Pssm-ID: 227610 [Multi-domain]  Cd Length: 1243  Bit Score: 510.70  E-value: 6.50e-159
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760   71 IVGIQDLLDQESVCVATASGDVI-VCNVSTQQ---LECVGNVASGISVMSWSPDQELLLLATAQQTLIMMTRDYEVITEQ 146
Cdd:COG5290     70 LLSFKHFHVLTFEYFLIDEGDIIhLVNDPTPAeleMEIVGKVSNGIVAASWSADEKTWCVVTSTREILLFDKYFDPISEY 149

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760  147 QIHQDDFGE-GKFITVGWGSKDTQFHG----SEGRPITFPVQMHESALS-WDDHRPQITWRGDGQFFAVSVVcSQTGARK 220
Cdd:COG5290    150 HLKKSDLVEfGKHIRVGWGKKETQFRGkgarAQLRDPTMPYMVDYGDLFaVDTNKKIIFWRGDTEYNLVGRS-EERPRRA 228

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760  221 IRVWNREFALQSTSESVPGLGPSLAWKPSGSLIASTQDKP--NQQDVVFFEKNGLLHGYFTLPFLKDEvKVNDLLWNADS 298
Cdd:COG5290    229 FRVYSREGQLDSASEPVTGMEHQLSWKPQGSKYATIGTDGcsTSESVIFFERNGLRHGEFDLRVGCDE-KAFLENWNLLS 307

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760  299 SVLAVWLEDLpkegsstlksyVQLWTVGNYHWYLKQSLPFSttgknQIVSLLWDPVTPGRLhVLCQGWRYLCCDWHWTTD 378
Cdd:COG5290    308 TVLAVAEGNL-----------LKLWTTKNYHWYLKVERQIP-----GISYVKWHPEEKNTL-LFRDGERILRVFFSEKKT 370

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760  379 RSSGNSADDLANVAVIDGNKVLVTVFQRTVTPPPMCTYRLLIPHpvNQVMFSAHLGNDLAVLDASNQISVYKCDDKPDMD 458
Cdd:COG5290    371 HHGSEYPFDNGTSYVIDGSYMLYTPLSLKNLPPPMFSVRVGFDT--NVVDVFPSFAEKKGAALLRDRLIMFRWDSEEFIN 448

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760  459 stvklgavggtgfkvplrtphlekryriQFGNKEEEEDVSPLQFRFLTWIEGDAFLAISHSHSSPQSIIhhltmagSEGD 538
Cdd:COG5290    449 ----------------------------KRTEFLESEFDSIVLFDGFLVLKSGHVFLLKDTNNESDTYI-------TRNG 493

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760  539 EEQGQLNVSSSVTVDGVVIGLCCCSKTKssAVQLADGQVLKYLWESPSSAVepwknsegrpVRFARPCTQMEAAAIGGEE 618
Cdd:COG5290    494 DVDERKKRGTVETRRTSTLVHQLCQTLL--RYGTCVGVVKHYNFEEKLYEL----------LKFPNGVIDFSVDPVHSTL 561

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760  619 CVLGLTDRCRFFINDTEVASNITSFAVCDDFLLVTTHSHTCQcFSLSGASLKMLQAGLCGSQVPSGEILRKVERGSRIVT 698
Cdd:COG5290    562 VAIGITDIGQLFALQVLLKKSVFSHNGTKLFVLFTTTENILS-FVHLESTFKPLITVEEGTVRFFDERKRSVERGSHKVE 640

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760  699 VVPQDTKLILQMPRGNLEVVHHRALVLAQIRKWLDKLMFKEAFECMRKLRINLNLIHDHNPKVFLENVETFIKQIDSVNH 778
Cdd:COG5290    641 LLPSKDFVVLQVTRGNLETIYPRIMVLAFVRKLIAAKKYKDAFDVCRTHRVPLGILLDYDPELFIENLEVFVTECRRVDY 720

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760  779 LNLFFTELKEEDVTKTMYpPPVTKSVQV--STNPDGKKVDLICDAMR-VAMETINPRKFCLSILTSHVKKTTPELDIVLQ 855
Cdd:COG5290    721 LSLFSEALQRDDVTKTDY-SFISKSEQArrFRKVFDLKVNLECKDTReHLESLIYNDESIQTIITAYLIGNPGNGKAALM 799

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760  856 KVHELqgkipfEPESVSAEEALKYLLLLVDVNELFNHSLGTYDFDLVLMVAEKSQKDPKEYLPFLNTLKKMETNYQRFTI 935
Cdd:COG5290    800 RISPL------SRCSESLDEDVKNLCFLRDVNFFNEFALSLYDKSLALLIAQLSQKDPREYLPFLVERQDLEALRRKFSI 873

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760  936 DKYLKRYEKALGHLSKCgPEYFTECLNLIKDKNLYKEALKLYRPDSPQYQAVSVAYGEHLVQEHLYEPAGLVFARCGAHE 1015
Cdd:COG5290    874 DNYLSIYESALGHLNED-LNVIREVMKYICRHDLYDFLLLLYRYDGELQKFKINIFAGNLVDNLYHISAAKAYEVEGKYI 952

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760 1016 KALEAFLACGSWQQalCMAAQLQMAKDKVAGLARTLAGKL-VEQRKHSEAATVLEQYAQDYEEAVLLLLEGSAWEEALRL 1094
Cdd:COG5290    953 EAHGAYDSALMWRE--CGSISTQEKGYEFNLCAELLPSDLlVEFRKAGDAEKILLTYLENLYEAVAMDCKGSEYREAFCE 1030

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760 1095 VYKYDRVDIIETSVKPSILE----AQKNYMDF---LDSQTatfirhkNRLKVVRELKSQAPRVHVDHEVAHGRETDLFSE 1167
Cdd:COG5290   1031 AMVSRLVESEKHYEAGQLGEefggKPELAADEyvqIKSQG-------DRLRVLRDKKCEMPEAREILREELLTLDDVSEA 1103

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760 1168 TSSIRSGSEMSGRYSHSN--SRISARSSKNRRKAERKKHSLKEGSPLEGLALLEALSEVVQSIEKLKDEVHAILKVLFLF 1245
Cdd:COG5290   1104 FVKYSTRLSALTEYTKDEcmSKTSRSTTKNMRRGERKRARGKKGTRYEEEYLVSSIRRLILRLVGWRPETERLVEILKRF 1183

                         1210      1220      1230
                   ....*....|....*....|....*....|
gi 2047705760 1246 EFEEQARELQRAFESTLQLMGTALPDIWTL 1275
Cdd:COG5290   1184 NMEEQARAHQTNFDEVGRAIKTEVDSIFSV 1213
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
939-1100 3.30e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 40.76  E-value: 3.30e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760  939 LKRYEKALGHLSKC---GPEYFtECLNLI----KDKNLYKEALKLYRpdspqyQAVSVAYGEHLVQEHLyepaGLVFARC 1011
Cdd:COG0457     55 LGRYEEALADYEQAlelDPDDA-EALNNLglalQALGRYEEALEDYD------KALELDPDDAEALYNL----GLALLEL 123

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047705760 1012 GAHEKALEAFlacgswQQALCMaaqlqmaKDKVAGLARTLAGKLVEQRKHSEAATVLEQYAQDYEEAVLLLLEGSAWEEA 1091
Cdd:COG0457    124 GRYDEAIEAY------ERALEL-------DPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALAL 190


                   ....*....
gi 2047705760 1092 LRLVYKYDR 1100
Cdd:COG0457    191 AAAEVLLAL 199
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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