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Conserved domains on  [gi|18376839|ref|NP_543182|]
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DNA damage-inducible transcript 4 protein [Rattus norvegicus]

Protein Classification

RTP801_C domain-containing protein( domain architecture ID 10544696)

RTP801_C domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RTP801_C pfam07809
RTP801 C-terminal region; The members of this family are sequences similar to the C-terminal ...
 101-220 4.51e-57

RTP801 C-terminal region; The members of this family are sequences similar to the C-terminal region of RTP801, the protein product of a hypoxia-inducible factor 1 (HIF-1)- responsive gene. Two members of this family expressed by Drosophila melanogaster, Scylla and Charybde, are designated by the GenBank as Hox targets. RTP801 is thought to be involved in various cellular processes. Its overexpression caused the apoptosis- resistant phenotype in cycling cells, and apoptosis sensitivity in growth arrested cells. Moreover, the protein product of the mouse homolog of RTP801 (dig2) is thought to be induced by diverse apoptotic signals, and also by dexamethasone treatment.


:

Pssm-ID: 462274  Cd Length: 116  Bit Score: 177.01  E-value: 4.51e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18376839   101 LSQARLGSRRPARLLMPSQLLSQVGKELLRLAYSEPCGLRGALLDVCVEQGKSCHSVAQLALDPSLVPTFQLTLVLRLDS 180
Cdd:pfam07809   1 LRAAKRTSLACSELLLPADLLHRIARDVLRLAESEPCGLRGALIDLCVEDGDGCRRLGQIKVDPSTVPTFELTLVLRQDS 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 18376839   181 RLWPKIQGLLSSANsslvPGYSQSLTLSTGFRVIKKKLYS 220
Cdd:pfam07809  81 SGWPSIQPLFKSFN----LTRGSTLKLSPGFRLIKRKLYS 116
 
Name Accession Description Interval E-value
RTP801_C pfam07809
RTP801 C-terminal region; The members of this family are sequences similar to the C-terminal ...
 101-220 4.51e-57

RTP801 C-terminal region; The members of this family are sequences similar to the C-terminal region of RTP801, the protein product of a hypoxia-inducible factor 1 (HIF-1)- responsive gene. Two members of this family expressed by Drosophila melanogaster, Scylla and Charybde, are designated by the GenBank as Hox targets. RTP801 is thought to be involved in various cellular processes. Its overexpression caused the apoptosis- resistant phenotype in cycling cells, and apoptosis sensitivity in growth arrested cells. Moreover, the protein product of the mouse homolog of RTP801 (dig2) is thought to be induced by diverse apoptotic signals, and also by dexamethasone treatment.


Pssm-ID: 462274  Cd Length: 116  Bit Score: 177.01  E-value: 4.51e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18376839   101 LSQARLGSRRPARLLMPSQLLSQVGKELLRLAYSEPCGLRGALLDVCVEQGKSCHSVAQLALDPSLVPTFQLTLVLRLDS 180
Cdd:pfam07809   1 LRAAKRTSLACSELLLPADLLHRIARDVLRLAESEPCGLRGALIDLCVEDGDGCRRLGQIKVDPSTVPTFELTLVLRQDS 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 18376839   181 RLWPKIQGLLSSANsslvPGYSQSLTLSTGFRVIKKKLYS 220
Cdd:pfam07809  81 SGWPSIQPLFKSFN----LTRGSTLKLSPGFRLIKRKLYS 116
 
Name Accession Description Interval E-value
RTP801_C pfam07809
RTP801 C-terminal region; The members of this family are sequences similar to the C-terminal ...
 101-220 4.51e-57

RTP801 C-terminal region; The members of this family are sequences similar to the C-terminal region of RTP801, the protein product of a hypoxia-inducible factor 1 (HIF-1)- responsive gene. Two members of this family expressed by Drosophila melanogaster, Scylla and Charybde, are designated by the GenBank as Hox targets. RTP801 is thought to be involved in various cellular processes. Its overexpression caused the apoptosis- resistant phenotype in cycling cells, and apoptosis sensitivity in growth arrested cells. Moreover, the protein product of the mouse homolog of RTP801 (dig2) is thought to be induced by diverse apoptotic signals, and also by dexamethasone treatment.


Pssm-ID: 462274  Cd Length: 116  Bit Score: 177.01  E-value: 4.51e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18376839   101 LSQARLGSRRPARLLMPSQLLSQVGKELLRLAYSEPCGLRGALLDVCVEQGKSCHSVAQLALDPSLVPTFQLTLVLRLDS 180
Cdd:pfam07809   1 LRAAKRTSLACSELLLPADLLHRIARDVLRLAESEPCGLRGALIDLCVEDGDGCRRLGQIKVDPSTVPTFELTLVLRQDS 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 18376839   181 RLWPKIQGLLSSANsslvPGYSQSLTLSTGFRVIKKKLYS 220
Cdd:pfam07809  81 SGWPSIQPLFKSFN----LTRGSTLKLSPGFRLIKRKLYS 116
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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