|
Name |
Accession |
Description |
Interval |
E-value |
| A_deaminase |
pfam00962 |
Adenosine deaminase; |
10-349 |
9.65e-160 |
|
Adenosine deaminase;
Pssm-ID: 425964 Cd Length: 330 Bit Score: 450.34 E-value: 9.65e-160
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18426812 10 PKVELHVHLDGAIKPETILYYGKKRGIDLPADTVEGLRNIIGM-DKPLSLPDFLAKFDYYmPAIAGCREAIKRIAYEFVE 88
Cdd:pfam00962 1 PKAELHLHLDGSLRPDTLLELAKRYGIILPADFPEALEPLFRKyKKERDLQDFLDKYDIG-VAVLRSPEDIRRLAFEYAE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18426812 89 MKAKEGVVYVEVRYSPHLLANSkvdpipwnqaegDLTPDEVVDLVNQGLQEGEQAFGIKVRSILCCMRH-QPSWSPEVLE 167
Cdd:pfam00962 80 DVAKDGVVYAEVRYDPQSHASR------------GLSPDTVVDAVLDAVDAAEREFGITVRLIVCAMRHeHPECSREIAE 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18426812 168 LCKKYHQKTVVAMDLAGDETIEGSSLFPGHVEAYEGAVKDGIHRTVHAGEVGSAEVVREAVDILKTERVGHGYHTIEDEA 247
Cdd:pfam00962 148 LAPRYRDQGIVAFGLAGDEKGFPPSLFRDHVEAFARARDAGLHLTVHAGEAGGPQSVWEALDDLGAERIGHGVRSAEDPR 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18426812 248 LYNRLLKENMHFEVCPWSSYLTGAWNPKTTHAVVRFKDDQANYSLNSDDPLIFKSTVDTDYQMVKKDMGFTEEEFKRLNI 327
Cdd:pfam00962 228 LLDRLADRQIPLEICPTSNVQTGAVASLAEHPLKTFLRAGVPVSLNTDDPLMFGSDLLDEYQVAKRAPGFDEEELARLAK 307
|
330 340
....*....|....*....|..
gi 18426812 328 NAAKSSFLPEDEKKELLERLYK 349
Cdd:pfam00962 308 NAVKGSFLPADEKRALLDEVDK 329
|
|
| aden_deam |
TIGR01430 |
adenosine deaminase; This family includes the experimentally verified adenosine deaminases of ... |
9-347 |
3.29e-151 |
|
adenosine deaminase; This family includes the experimentally verified adenosine deaminases of mammals and E. coli. Other members of this family are predicted also to be adenosine deaminase, an enzyme of nucleotide degradation. This family is distantly related to AMP deaminase.
Pssm-ID: 273619 Cd Length: 324 Bit Score: 428.31 E-value: 3.29e-151
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18426812 9 KPKVELHVHLDGAIKPETILYYGKKRGIDLPADTVEGLRNIIGMDKPLSLPDFLAKFDYYMPAIaGCREAIKRIAYEFVE 88
Cdd:TIGR01430 1 LPKAELHLHLEGSIRPETLLELAQKNGIPLPADLQSGEELKEAYDKFRDLQDFLAKYDFGVEVL-RTEDDFKRLAYEYVE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18426812 89 MKAKEGVVYVEVRYSPHLLANSKvdpipwnqaegdLTPDEVVDLVNQGLQEGEQAFGIKVRSILCCMRH-QPSWSPEVLE 167
Cdd:TIGR01430 80 KAAKDGVVYAEVFFDPQLHTNRG------------ISPDTVVEAVLDGLDEAERDFGIKSRLILCGMRHkQPEAAEETLE 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18426812 168 LCKKYHQKTVVAMDLAGDETIEGsslFPGHVEAYEGAVKDGIHRTVHAGEVGSAEVVREAVDILKTERVGHGYHTIEDEA 247
Cdd:TIGR01430 148 LAKPYKEQTIVGFGLAGDERGGP---PPDFVRAFAIARELGLHLTVHAGELGGPESVREALDDLGATRIGHGVRALEDPE 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18426812 248 LYNRLLKENMHFEVCPWSSYLTGAWNPKTTHAVVRFKDDQANYSLNSDDPLIFKSTVDTDYQMVKKDMGFTEEEFKRLNI 327
Cdd:TIGR01430 225 LLKRLAQENITLEVCPTSNVALGVVKSLAEHPLRRFLEAGVKVTLNSDDPAYFGSYLTEEYEIAAKHAGLTEEELKQLAR 304
|
330 340
....*....|....*....|
gi 18426812 328 NAAKSSFLPEDEKKELLERL 347
Cdd:TIGR01430 305 NALEGSFLSDDEKKELLAKL 324
|
|
| ADA |
cd01320 |
Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the ... |
8-347 |
5.73e-149 |
|
Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in the purine pathway. Low, as well as high levels of ADA activity have been linked to several diseases.
Pssm-ID: 238645 Cd Length: 325 Bit Score: 422.77 E-value: 5.73e-149
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18426812 8 NKPKVELHVHLDGAIKPETILYYGKKRGIDLPADTVEGLRNIIGMDKPLSLPDFLAKFDYYMPAIAGcREAIKRIAYEFV 87
Cdd:cd01320 1 NLPKAELHLHLDGSLRPETILELAKKNGITLPASDVELLELVVAAYNFSDLQDFLAKYDFGLSVLQT-EEDFERLAYEYL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18426812 88 EMKAKEGVVYVEVRYSPHLLAnskvdpipwnqaEGDLTPDEVVDLVNQGLQEGEQAFGIKVRSILCCMRHQP-SWSPEVL 166
Cdd:cd01320 80 EDAAADGVVYAEIRFSPQLHT------------RRGLSFDEVVEAVLRGLDEAEAEFGIKARLILCGLRHLSpESAQETL 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18426812 167 ELCKKYHQKTVVAMDLAGDETIEgssLFPGHVEAYEGAVKDGIHRTVHAGEVGSAEVVREAVDILKTERVGHGYHTIEDE 246
Cdd:cd01320 148 ELALKYRDKGVVGFDLAGDEVGF---PPEKFVRAFQRAREAGLRLTAHAGEAGGPESVRDALDLLGAERIGHGIRAIEDP 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18426812 247 ALYNRLLKENMHFEVCPWSSYLTGAWNPKTTHAVVRFKDDQANYSLNSDDPLIFKSTVDTDYQMVKKDMGFTEEEFKRLN 326
Cdd:cd01320 225 ELVKRLAERNIPLEVCPTSNVQTGAVKSLAEHPLRELLDAGVKVTINTDDPTVFGTYLTDEYELLAEAFGLTEEELKKLA 304
|
330 340
....*....|....*....|.
gi 18426812 327 INAAKSSFLPEDEKKELLERL 347
Cdd:cd01320 305 RNAVEASFLSEEEKAELLKRI 325
|
|
| Add |
COG1816 |
Adenosine deaminase [Nucleotide transport and metabolism]; Adenosine deaminase is part of the ... |
10-352 |
1.07e-109 |
|
Adenosine deaminase [Nucleotide transport and metabolism]; Adenosine deaminase is part of the Pathway/BioSystem: Menaquinone biosynthesis
Pssm-ID: 441421 Cd Length: 326 Bit Score: 323.19 E-value: 1.07e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18426812 10 PKVELHVHLDGAIKPETILYYGKKRGIDLPADTVEGLRNIIGMDkplSLPDFLAKFDYYMPAIAGcREAIKRIAYEFVEM 89
Cdd:COG1816 1 PKAELHLHLEGSLRPETLLELAARNGIDLPAADVEELRAAYDFR---DLQSFLDTYDAGAAVLQT-EEDFRRLAYEYLED 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18426812 90 KAKEGVVYVEVRYSPHLLAnskvdpipwnqaEGDLTPDEVVDLVNQGLQEGEQAFGIKVRSILCCMRHQ-PSWSPEVLEL 168
Cdd:COG1816 77 AAADGVRYAEIRFDPQLHT------------RRGLSLEEVVEAVLDGLREAEREFGISVRLILCALRHLsPEAAFETLEL 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18426812 169 CKKYHQKTVVAMDLAGDETiegssLFPG--HVEAYEGAVKDGIHRTVHAGEVGSAEVVREAVDILKTERVGHGYHTIEDE 246
Cdd:COG1816 145 ALRYRDRGVVGFGLAGDER-----GFPPekFAEAFARAREAGLHLTAHAGEAGGPESIWEALDLLGAERIGHGVRAIEDP 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18426812 247 ALYNRLLKENMHFEVCPWSSYLTGAWNPKTTHAVVRFKDDQANYSLNSDDPLIFKSTVDTDYQMVKKDMGFTEEEFKRLN 326
Cdd:COG1816 220 ALVARLADRGIPLEVCPTSNVQLGVVPSLAEHPLRRLLDAGVRVTLNTDDPLYFGTTLTDEYELAAEAFGLSDADLAQLA 299
|
330 340
....*....|....*....|....*.
gi 18426812 327 INAAKSSFLPEDEKKELLERLYKEYQ 352
Cdd:COG1816 300 RNAIEASFLPEEEKAALLAELDAYFA 325
|
|
| PRK09358 |
PRK09358 |
adenosine deaminase; Provisional |
10-347 |
5.72e-97 |
|
adenosine deaminase; Provisional
Pssm-ID: 236480 Cd Length: 340 Bit Score: 290.93 E-value: 5.72e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18426812 10 PKVELHVHLDGAIKPETILYYGKKRGIDLPADTVEGLRNIIGMDKPLSLPDFLAKFDYYMPAIAGcREAIKRIAYEFVEM 89
Cdd:PRK09358 11 PKAELHLHLDGSLRPETILELARRNGIALPATDVEELPWVRAAYDFRDLQSFLDKYDAGVAVLQT-EEDLRRLAFEYLED 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18426812 90 KAKEGVVYVEVRYSPhllanskvdpipWNQAEGDLTPDEVVDLVNQGLQEGEQAFGIKVRSILCCMRH--QPSWSPEVLE 167
Cdd:PRK09358 90 AAADGVVYAEIRFDP------------QLHTERGLPLEEVVEAVLDGLRAAEAEFGISVRLILCFMRHfgEEAAARELEA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18426812 168 LCKKYHQKTVVAMDLAGDETIEGSSLFpghVEAYEGAVKDGIHRTVHAGEVGSAEVVREAVDILKTERVGHGYHTIEDEA 247
Cdd:PRK09358 158 LAARYRDDGVVGFDLAGDELGFPPSKF---ARAFDRARDAGLRLTAHAGEAGGPESIWEALDELGAERIGHGVRAIEDPA 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18426812 248 LYNRLLKENMHFEVCPWSSYLTGAWNPKTTHAVVRFKDDQANYSLNSDDPLIFKSTVDTDYQMVKKDMGFTEEEFKRLNI 327
Cdd:PRK09358 235 LMARLADRRIPLEVCPTSNVQTGAVPSLAEHPLKTLLDAGVRVTINTDDPLVFGTTLTEEYEALAEAFGLSDEDLAQLAR 314
|
330 340
....*....|....*....|
gi 18426812 328 NAAKSSFLPEDEKKELLERL 347
Cdd:PRK09358 315 NALEAAFLSEEEKAALLAEV 334
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| A_deaminase |
pfam00962 |
Adenosine deaminase; |
10-349 |
9.65e-160 |
|
Adenosine deaminase;
Pssm-ID: 425964 Cd Length: 330 Bit Score: 450.34 E-value: 9.65e-160
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18426812 10 PKVELHVHLDGAIKPETILYYGKKRGIDLPADTVEGLRNIIGM-DKPLSLPDFLAKFDYYmPAIAGCREAIKRIAYEFVE 88
Cdd:pfam00962 1 PKAELHLHLDGSLRPDTLLELAKRYGIILPADFPEALEPLFRKyKKERDLQDFLDKYDIG-VAVLRSPEDIRRLAFEYAE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18426812 89 MKAKEGVVYVEVRYSPHLLANSkvdpipwnqaegDLTPDEVVDLVNQGLQEGEQAFGIKVRSILCCMRH-QPSWSPEVLE 167
Cdd:pfam00962 80 DVAKDGVVYAEVRYDPQSHASR------------GLSPDTVVDAVLDAVDAAEREFGITVRLIVCAMRHeHPECSREIAE 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18426812 168 LCKKYHQKTVVAMDLAGDETIEGSSLFPGHVEAYEGAVKDGIHRTVHAGEVGSAEVVREAVDILKTERVGHGYHTIEDEA 247
Cdd:pfam00962 148 LAPRYRDQGIVAFGLAGDEKGFPPSLFRDHVEAFARARDAGLHLTVHAGEAGGPQSVWEALDDLGAERIGHGVRSAEDPR 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18426812 248 LYNRLLKENMHFEVCPWSSYLTGAWNPKTTHAVVRFKDDQANYSLNSDDPLIFKSTVDTDYQMVKKDMGFTEEEFKRLNI 327
Cdd:pfam00962 228 LLDRLADRQIPLEICPTSNVQTGAVASLAEHPLKTFLRAGVPVSLNTDDPLMFGSDLLDEYQVAKRAPGFDEEELARLAK 307
|
330 340
....*....|....*....|..
gi 18426812 328 NAAKSSFLPEDEKKELLERLYK 349
Cdd:pfam00962 308 NAVKGSFLPADEKRALLDEVDK 329
|
|
| aden_deam |
TIGR01430 |
adenosine deaminase; This family includes the experimentally verified adenosine deaminases of ... |
9-347 |
3.29e-151 |
|
adenosine deaminase; This family includes the experimentally verified adenosine deaminases of mammals and E. coli. Other members of this family are predicted also to be adenosine deaminase, an enzyme of nucleotide degradation. This family is distantly related to AMP deaminase.
Pssm-ID: 273619 Cd Length: 324 Bit Score: 428.31 E-value: 3.29e-151
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18426812 9 KPKVELHVHLDGAIKPETILYYGKKRGIDLPADTVEGLRNIIGMDKPLSLPDFLAKFDYYMPAIaGCREAIKRIAYEFVE 88
Cdd:TIGR01430 1 LPKAELHLHLEGSIRPETLLELAQKNGIPLPADLQSGEELKEAYDKFRDLQDFLAKYDFGVEVL-RTEDDFKRLAYEYVE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18426812 89 MKAKEGVVYVEVRYSPHLLANSKvdpipwnqaegdLTPDEVVDLVNQGLQEGEQAFGIKVRSILCCMRH-QPSWSPEVLE 167
Cdd:TIGR01430 80 KAAKDGVVYAEVFFDPQLHTNRG------------ISPDTVVEAVLDGLDEAERDFGIKSRLILCGMRHkQPEAAEETLE 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18426812 168 LCKKYHQKTVVAMDLAGDETIEGsslFPGHVEAYEGAVKDGIHRTVHAGEVGSAEVVREAVDILKTERVGHGYHTIEDEA 247
Cdd:TIGR01430 148 LAKPYKEQTIVGFGLAGDERGGP---PPDFVRAFAIARELGLHLTVHAGELGGPESVREALDDLGATRIGHGVRALEDPE 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18426812 248 LYNRLLKENMHFEVCPWSSYLTGAWNPKTTHAVVRFKDDQANYSLNSDDPLIFKSTVDTDYQMVKKDMGFTEEEFKRLNI 327
Cdd:TIGR01430 225 LLKRLAQENITLEVCPTSNVALGVVKSLAEHPLRRFLEAGVKVTLNSDDPAYFGSYLTEEYEIAAKHAGLTEEELKQLAR 304
|
330 340
....*....|....*....|
gi 18426812 328 NAAKSSFLPEDEKKELLERL 347
Cdd:TIGR01430 305 NALEGSFLSDDEKKELLAKL 324
|
|
| ADA |
cd01320 |
Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the ... |
8-347 |
5.73e-149 |
|
Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in the purine pathway. Low, as well as high levels of ADA activity have been linked to several diseases.
Pssm-ID: 238645 Cd Length: 325 Bit Score: 422.77 E-value: 5.73e-149
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18426812 8 NKPKVELHVHLDGAIKPETILYYGKKRGIDLPADTVEGLRNIIGMDKPLSLPDFLAKFDYYMPAIAGcREAIKRIAYEFV 87
Cdd:cd01320 1 NLPKAELHLHLDGSLRPETILELAKKNGITLPASDVELLELVVAAYNFSDLQDFLAKYDFGLSVLQT-EEDFERLAYEYL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18426812 88 EMKAKEGVVYVEVRYSPHLLAnskvdpipwnqaEGDLTPDEVVDLVNQGLQEGEQAFGIKVRSILCCMRHQP-SWSPEVL 166
Cdd:cd01320 80 EDAAADGVVYAEIRFSPQLHT------------RRGLSFDEVVEAVLRGLDEAEAEFGIKARLILCGLRHLSpESAQETL 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18426812 167 ELCKKYHQKTVVAMDLAGDETIEgssLFPGHVEAYEGAVKDGIHRTVHAGEVGSAEVVREAVDILKTERVGHGYHTIEDE 246
Cdd:cd01320 148 ELALKYRDKGVVGFDLAGDEVGF---PPEKFVRAFQRAREAGLRLTAHAGEAGGPESVRDALDLLGAERIGHGIRAIEDP 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18426812 247 ALYNRLLKENMHFEVCPWSSYLTGAWNPKTTHAVVRFKDDQANYSLNSDDPLIFKSTVDTDYQMVKKDMGFTEEEFKRLN 326
Cdd:cd01320 225 ELVKRLAERNIPLEVCPTSNVQTGAVKSLAEHPLRELLDAGVKVTINTDDPTVFGTYLTDEYELLAEAFGLTEEELKKLA 304
|
330 340
....*....|....*....|.
gi 18426812 327 INAAKSSFLPEDEKKELLERL 347
Cdd:cd01320 305 RNAVEASFLSEEEKAELLKRI 325
|
|
| Add |
COG1816 |
Adenosine deaminase [Nucleotide transport and metabolism]; Adenosine deaminase is part of the ... |
10-352 |
1.07e-109 |
|
Adenosine deaminase [Nucleotide transport and metabolism]; Adenosine deaminase is part of the Pathway/BioSystem: Menaquinone biosynthesis
Pssm-ID: 441421 Cd Length: 326 Bit Score: 323.19 E-value: 1.07e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18426812 10 PKVELHVHLDGAIKPETILYYGKKRGIDLPADTVEGLRNIIGMDkplSLPDFLAKFDYYMPAIAGcREAIKRIAYEFVEM 89
Cdd:COG1816 1 PKAELHLHLEGSLRPETLLELAARNGIDLPAADVEELRAAYDFR---DLQSFLDTYDAGAAVLQT-EEDFRRLAYEYLED 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18426812 90 KAKEGVVYVEVRYSPHLLAnskvdpipwnqaEGDLTPDEVVDLVNQGLQEGEQAFGIKVRSILCCMRHQ-PSWSPEVLEL 168
Cdd:COG1816 77 AAADGVRYAEIRFDPQLHT------------RRGLSLEEVVEAVLDGLREAEREFGISVRLILCALRHLsPEAAFETLEL 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18426812 169 CKKYHQKTVVAMDLAGDETiegssLFPG--HVEAYEGAVKDGIHRTVHAGEVGSAEVVREAVDILKTERVGHGYHTIEDE 246
Cdd:COG1816 145 ALRYRDRGVVGFGLAGDER-----GFPPekFAEAFARAREAGLHLTAHAGEAGGPESIWEALDLLGAERIGHGVRAIEDP 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18426812 247 ALYNRLLKENMHFEVCPWSSYLTGAWNPKTTHAVVRFKDDQANYSLNSDDPLIFKSTVDTDYQMVKKDMGFTEEEFKRLN 326
Cdd:COG1816 220 ALVARLADRGIPLEVCPTSNVQLGVVPSLAEHPLRRLLDAGVRVTLNTDDPLYFGTTLTDEYELAAEAFGLSDADLAQLA 299
|
330 340
....*....|....*....|....*.
gi 18426812 327 INAAKSSFLPEDEKKELLERLYKEYQ 352
Cdd:COG1816 300 RNAIEASFLPEEEKAALLAELDAYFA 325
|
|
| ADA_AMPD |
cd00443 |
Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic ... |
9-347 |
1.55e-99 |
|
Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase catalyzes a similar reaction leading to the hydrolytic removal of an amino group at the 6 position of the adenine nucleotide ring, a branch point in the adenylate catabolic pathway.
Pssm-ID: 238250 Cd Length: 305 Bit Score: 296.57 E-value: 1.55e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18426812 9 KPKVELHVHLDGAIKPETILYYGKKRgidlpadtveglrniigmdkplslpdFLAKFDYYMPAIaGCREAIKRIAYEFVE 88
Cdd:cd00443 1 LPKVELHAHLSGSISPETLLELIKKE--------------------------FFEKFLLVHNLL-QKGEALARALKEVIE 53
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18426812 89 MKAKEGVVYVEVRYSPHLLANSKvdpipwnqaegDLTPDEVVDLVNQGLQEGEQAF-GIKVRSILCCMRHQPS-----WS 162
Cdd:cd00443 54 EFAEDNVQYLELRTTPRLLETEK-----------GLTKEQYWLLVIEGISEAKQWFpPIKVRLILSVDRRGPYvqnylVA 122
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18426812 163 PEVLELCKKYHQkTVVAMDLAGDETIEGSsLFPGHVEAYEGAVKDG-IHRTVHAGEVGSAEVVREAVDiLKTERVGHGYH 241
Cdd:cd00443 123 SEILELAKFLSN-YVVGIDLVGDESKGEN-PLRDFYSYYEYARRLGlLGLTLHCGETGNREELLQALL-LLPDRIGHGIF 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18426812 242 TIEDEALYNRLLKENMHFEVCPWSSYLTGAWNPKTTHAVVRFKDDQANYSLNSDDPLIFKSTVDTDYQMVKKDMGFTEEE 321
Cdd:cd00443 200 LLKHPELIYLVKLRNIPIEVCPTSNVVLGTVQSYEKHPFMRFFKAGLPVSLSTDDPGIFGTSLSEEYSLAAKTFGLTFED 279
|
330 340
....*....|....*....|....*.
gi 18426812 322 FKRLNINAAKSSFLPEDEKKELLERL 347
Cdd:cd00443 280 LCELNRNSVLSSFAKDEEKKSLLEVL 305
|
|
| PRK09358 |
PRK09358 |
adenosine deaminase; Provisional |
10-347 |
5.72e-97 |
|
adenosine deaminase; Provisional
Pssm-ID: 236480 Cd Length: 340 Bit Score: 290.93 E-value: 5.72e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18426812 10 PKVELHVHLDGAIKPETILYYGKKRGIDLPADTVEGLRNIIGMDKPLSLPDFLAKFDYYMPAIAGcREAIKRIAYEFVEM 89
Cdd:PRK09358 11 PKAELHLHLDGSLRPETILELARRNGIALPATDVEELPWVRAAYDFRDLQSFLDKYDAGVAVLQT-EEDLRRLAFEYLED 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18426812 90 KAKEGVVYVEVRYSPhllanskvdpipWNQAEGDLTPDEVVDLVNQGLQEGEQAFGIKVRSILCCMRH--QPSWSPEVLE 167
Cdd:PRK09358 90 AAADGVVYAEIRFDP------------QLHTERGLPLEEVVEAVLDGLRAAEAEFGISVRLILCFMRHfgEEAAARELEA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18426812 168 LCKKYHQKTVVAMDLAGDETIEGSSLFpghVEAYEGAVKDGIHRTVHAGEVGSAEVVREAVDILKTERVGHGYHTIEDEA 247
Cdd:PRK09358 158 LAARYRDDGVVGFDLAGDELGFPPSKF---ARAFDRARDAGLRLTAHAGEAGGPESIWEALDELGAERIGHGVRAIEDPA 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18426812 248 LYNRLLKENMHFEVCPWSSYLTGAWNPKTTHAVVRFKDDQANYSLNSDDPLIFKSTVDTDYQMVKKDMGFTEEEFKRLNI 327
Cdd:PRK09358 235 LMARLADRRIPLEVCPTSNVQTGAVPSLAEHPLKTLLDAGVRVTINTDDPLVFGTTLTEEYEALAEAFGLSDEDLAQLAR 314
|
330 340
....*....|....*....|
gi 18426812 328 NAAKSSFLPEDEKKELLERL 347
Cdd:PRK09358 315 NALEAAFLSEEEKAALLAEV 334
|
|
| PTZ00124 |
PTZ00124 |
adenosine deaminase; Provisional |
10-343 |
1.02e-32 |
|
adenosine deaminase; Provisional
Pssm-ID: 173415 Cd Length: 362 Bit Score: 124.98 E-value: 1.02e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18426812 10 PKVELHVHLDGAIKPETILYYGKKRGIDLPADTVEGLRNIIGMDKPLSLPDFLAKfdyympAIAGCR-----EAIKRIAY 84
Cdd:PTZ00124 36 PKCELHCHLDLCFSVDFFLSCIRKYNLQPNLSDEEILDYYLFAKGGKSLGEFVEK------AIRVADifndyEVIEDLAK 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18426812 85 EFVEMKAKEGVVYVEVRYSPHLLANSKvdpipwnqaegDLTPDEVVDLVNQGLQEGEQAFGIKVRSILCCMR---HQPSW 161
Cdd:PTZ00124 110 HAVFNKYKEGVVLMEFRYSPTFVAFKH-----------NLDIDLIHQAIVKGIKEAVELLDHKIEVGLLCIGdtgHDAAP 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18426812 162 SPEVLELCKKyHQKTVVAMDLAGDETIegsslFPGHVEAYEGAVKDGIHRTVHAGEVGSAEVVRE---AVDILKTERVGH 238
Cdd:PTZ00124 179 IKESADFCLK-HKADFVGFDHAGHEVD-----LKPFKDIFDYVREAGVNLTVHAGEDVTLPNLNTlysAIQVLKVKRIGH 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18426812 239 GYHTIEDEALYNRLLKENMHFEVCPWSSYLTGAWNPKTTHAVVRFKDDQANYSLNSDDPLIFKSTVDTDYQMVKKDMGFT 318
Cdd:PTZ00124 253 GIRVAESQELIDMVKEKDILLEVCPISNVLLNNAKSMDTHPIRKLYDAGVKVSVNSDDPGMFLTNINDDYEELYTHLNFT 332
|
330 340
....*....|....*....|....*
gi 18426812 319 EEEFKRLNINAAKSSFLPEDEKKEL 343
Cdd:PTZ00124 333 LADFMKMNEWALEKSFLDKDIKLKI 357
|
|
| metallo-dependent_hydrolases |
cd01292 |
Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a ... |
11-331 |
1.85e-24 |
|
Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a conserved metal binding site, involving four histidines and one aspartic acid residue. In the common reaction mechanism, the metal ion (or ions) deprotonate a water molecule for a nucleophilic attack on the substrate. The family includes urease alpha, adenosine deaminase, phosphotriesterase dihydroorotases, allantoinases, hydantoinases, AMP-, adenine and cytosine deaminases, imidazolonepropionase, aryldialkylphosphatase, chlorohydrolases, formylmethanofuran dehydrogenases and others.
Pssm-ID: 238617 [Multi-domain] Cd Length: 275 Bit Score: 100.87 E-value: 1.85e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18426812 11 KVELHVHLDGAIKPETILYYGKKRgidlpadtveglrniigmdkplslpdflakfdyympAIAGCREAIKRIAYEFVEMK 90
Cdd:cd01292 1 FIDTHVHLDGSALRGTRLNLELKE------------------------------------AEELSPEDLYEDTLRALEAL 44
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18426812 91 AKEGVVYVEVRYSPHLLAnskvdpipwnqaegdlTPDEVVDLVNQGLQEGEqafGIKVRSILCCMRHQPSWS----PEVL 166
Cdd:cd01292 45 LAGGVTTVVDMGSTPPPT----------------TTKAAIEAVAEAARASA---GIRVVLGLGIPGVPAAVDedaeALLL 105
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18426812 167 ELCKKYHQKTVVAMDLAGDETIEGSSlFPGHVEAYEGAVKDGIHRTVHAGEVGSA-EVVREAVDILKTE---RVGHGYHT 242
Cdd:cd01292 106 ELLRRGLELGAVGLKLAGPYTATGLS-DESLRRVLEEARKLGLPVVIHAGELPDPtRALEDLVALLRLGgrvVIGHVSHL 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18426812 243 ieDEALYNRLLKENMHFEVCPWSSYLTGaWNPKTTHAVVRFKDDQANYSLNSDDPLIF-KSTVDTDYQMVKKDM--GFTE 319
Cdd:cd01292 185 --DPELLELLKEAGVSLEVCPLSNYLLG-RDGEGAEALRRLLELGIRVTLGTDGPPHPlGTDLLALLRLLLKVLrlGLSL 261
|
330
....*....|...
gi 18426812 320 EEFKRL-NINAAK 331
Cdd:cd01292 262 EEALRLaTINPAR 274
|
|
| ADGF |
cd01321 |
Adenosine deaminase-related growth factors (ADGF), a novel family of secreted growth-factors ... |
14-350 |
1.67e-13 |
|
Adenosine deaminase-related growth factors (ADGF), a novel family of secreted growth-factors with sequence similarty to adenosine deaminase.
Pssm-ID: 238646 Cd Length: 345 Bit Score: 70.38 E-value: 1.67e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18426812 14 LHVHLDGAIKPETILYYGKKRGIDLpADTVEGLRNiigmdkplslpdflakfdyYMPAIagcREAIKRIAYEFVEmkakE 93
Cdd:cd01321 30 LHVHDTAMVSSDWLIKNATYRFEQI-FDIIDGLLT-------------------YLPIF---RDYYRRLLEELYE----D 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18426812 94 GVVYVEVRYSPhllanskvdPIPWNQAEGDLTPDEVVDL----VNQGLQEGEQAFGIKVrsILCCMRH-QPSWSPEVLEL 168
Cdd:cd01321 83 NVQYVELRSSF---------SPLYDLDGREYDYEETVQLleevVEKFKKTHPDFIGLKI--IYATLRNfNDSEIKESMEQ 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18426812 169 CKKYHQK---TVVAMDLAGDETiEGSSLFPgHVEAYEGAVKDG--IHRTVHAGEVG--SAEVVREAVD--ILKTERVGHG 239
Cdd:cd01321 152 CLNLKKKfpdFIAGFDLVGQED-AGRPLLD-FLPQLLWFPKQCaeIPFFFHAGETNgdGTETDENLVDalLLNTKRIGHG 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18426812 240 YHTIEDEALYNRLLKENMHFEVCPWSSYLTGAWNPKTTHAVVRFKDDQANYSLNSDDPLIFKSTVDTD--YQMVkkdMGF 317
Cdd:cd01321 230 FALPKHPLLMDLVKKKNIAIEVCPISNQVLGLVSDLRNHPAAALLARGVPVVISSDDPGFWGAKGLSHdfYQAF---MGL 306
|
330 340 350
....*....|....*....|....*....|....*...
gi 18426812 318 TEEEF-----KRLNINAAKSSFLPEDEKKELLERLYKE 350
Cdd:cd01321 307 APADAglrglKQLAENSIRYSALSDQEKDEAVAKWEKK 344
|
|
| adm_rel |
TIGR01431 |
adenosine deaminase-related growth factor; Members of this family have been described as ... |
146-351 |
3.48e-10 |
|
adenosine deaminase-related growth factor; Members of this family have been described as secreted proteins with growth factor activity and regions of adenosine deaminase homology in insects, mollusks, and vertebrates.
Pssm-ID: 273620 [Multi-domain] Cd Length: 479 Bit Score: 60.97 E-value: 3.48e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18426812 146 IKVRSILCCMRhqpSWSPEVLE----LCKKYHQK---TVVAMDLAGDETiEGSSLFPGHVEAYEGAVKDGIHRTVHAGEV 218
Cdd:TIGR01431 255 IGIKIIYSDLR---SKDVEEIAeyikMAMGLRIKypdFVAGFDLVGQED-TGHSLLDYKDALLIPSIGVKLPYFFHAGET 330
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18426812 219 GS--AEVVREAVD--ILKTERVGHGYHTIEDEALYNRLLKENMHFEVCPWSSYLTGAWNPKTTHAVVRFKDDQANYSLNS 294
Cdd:TIGR01431 331 NWqgTSVDRNLLDalLLNTTRIGHGFALSKHPAVRTYSKERDIPIEVCPISNQVLKLVSDLRNHPVATLMADNYPMVISS 410
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 18426812 295 DDPLIFKST-VDTDYQMV-------KKDMGFteeeFKRLNINAAKSSFLPEDEKKELLERLYKEY 351
Cdd:TIGR01431 411 DDPAFWGAKgLSYDFYEAfmgiagmKADLRT----LKQLALNSIKYSALSEEEKNTAMAKWKKQW 471
|
|
| |
