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Conserved domains on  [gi|18640738|ref|NP_570124|]
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ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 isoform 1 [Homo sapiens]

Protein Classification

ANKYR and SAM_ASZ1 domain-containing protein( domain architecture ID 12789531)

ANKYR and SAM_ASZ1 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
53-234 3.23e-38

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 140.86  E-value: 3.23e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18640738  53 AMTIGDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILITACSAHGSEEqilkCV 132
Cdd:COG0666  61 AALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLE----IV 136

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18640738 133 ELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQT 212
Cdd:COG0666 137 KLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKD 216

                       170       180
                ....*....|....*....|..
gi 18640738 213 KDGKMPSEIAKRNKHHEIFNLL 234
Cdd:COG0666 217 NDGKTALDLAAENGNLEIVKLL 238
SAM_ASZ1 cd09521
SAM domain of ASZ1 subfamily; SAM (sterile alpha motif) domain of ASZ1 (Ankyrin, SAM, leucine ...
 272-334 1.90e-23

SAM domain of ASZ1 subfamily; SAM (sterile alpha motif) domain of ASZ1 (Ankyrin, SAM, leucine Zipper) also known as GASZ (Germ cell-specific Ankyrin, SAM, leucine Zipper) subfamily is a potential protein-protein interaction domain. Proteins of this group are involved in the repression of transposable elements during spermatogenesis, oogenesis, and preimplantation embryogenesis. They support synthesis of PIWI-interacting RNA via association with some PIWI proteins, such as MILI and MIWI. This association is required for initiation and maintenance of retrotransposon repression during the meiosis. In mice lacking ASZ1, DNA damage and delayed germ cell maturation was observed due to retrotransposons releasing from their repressed state.


:

Pssm-ID: 188920  Cd Length: 64  Bit Score: 93.12  E-value: 1.90e-23
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 18640738 272 SYTAFGDLEVFLHGLGLEHMTDLLKERDITLRHLLTMREDEFTKNGITS-KDQQKILAALKELQ 334
Cdd:cd09521   1 SYSKLDDLELFLHGLELGHLTPLFKEHDVTFSQLLKMTEEDLEKIGITQpGDQKKILDAIKEVH 64
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
53-234 3.23e-38

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 140.86  E-value: 3.23e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18640738  53 AMTIGDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILITACSAHGSEEqilkCV 132
Cdd:COG0666  61 AALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLE----IV 136

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18640738 133 ELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQT 212
Cdd:COG0666 137 KLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKD 216

                       170       180
                ....*....|....*....|..
gi 18640738 213 KDGKMPSEIAKRNKHHEIFNLL 234
Cdd:COG0666 217 NDGKTALDLAAENGNLEIVKLL 238
SAM_ASZ1 cd09521
SAM domain of ASZ1 subfamily; SAM (sterile alpha motif) domain of ASZ1 (Ankyrin, SAM, leucine ...
 272-334 1.90e-23

SAM domain of ASZ1 subfamily; SAM (sterile alpha motif) domain of ASZ1 (Ankyrin, SAM, leucine Zipper) also known as GASZ (Germ cell-specific Ankyrin, SAM, leucine Zipper) subfamily is a potential protein-protein interaction domain. Proteins of this group are involved in the repression of transposable elements during spermatogenesis, oogenesis, and preimplantation embryogenesis. They support synthesis of PIWI-interacting RNA via association with some PIWI proteins, such as MILI and MIWI. This association is required for initiation and maintenance of retrotransposon repression during the meiosis. In mice lacking ASZ1, DNA damage and delayed germ cell maturation was observed due to retrotransposons releasing from their repressed state.


Pssm-ID: 188920  Cd Length: 64  Bit Score: 93.12  E-value: 1.90e-23
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 18640738 272 SYTAFGDLEVFLHGLGLEHMTDLLKERDITLRHLLTMREDEFTKNGITS-KDQQKILAALKELQ 334
Cdd:cd09521   1 SYSKLDDLELFLHGLELGHLTPLFKEHDVTFSQLLKMTEEDLEKIGITQpGDQKKILDAIKEVH 64
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 59-281 3.13e-18

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 86.64  E-value: 3.13e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18640738   59 VSLVQELLDSGISVDSNFQYGWTPLMYAASV-----ANAELVRVLLDRGANASFEKDKQS----ILITACSAHgseeqiL 129
Cdd:PHA03100  48 IDVVKILLDNGADINSSTKNNSTPLHYLSNIkynltDVKEIVKLLLEYGANVNAPDNNGItpllYAISKKSNS------Y 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18640738  130 KCVELLLSRNADPNVACRRLMTPIMYAARDGH--TQVVALLVAHGAEVN----------------TQDENGYTALTWAAR 191
Cdd:PHA03100 122 SIVEYLLDNGANVNIKNSDGENLLHLYLESNKidLKILKLLIDKGVDINaknrvnyllsygvpinIKDVYGFTPLHYAVY 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18640738  192 QGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLLS---------------FTLNPLEGKLQQLTKEDTICK 256
Cdd:PHA03100 202 NNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLnngpsiktiietllyFKDKDLNTITKIKMLKKSIMY 281

                        250       260
                 ....*....|....*....|....*.
gi 18640738  257 ILTTDSDREKDH-IFSSYTAFGDLEV 281
Cdd:PHA03100 282 MFLLDPGFYKNRkLIENSKSLKDVIN 307
Ank_2 pfam12796
Ankyrin repeats (3 copies);
129-211 5.07e-18

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 79.00  E-value: 5.07e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18640738   129 LKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHgAEVNTQDeNGYTALTWAARQGHKNIVLKLLELGANK 208
Cdd:pfam12796  10 LELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVKLLLEKGADI 87


                  ...
gi 18640738   209 MLQ 211
Cdd:pfam12796  88 NVK 90
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 57-169 1.21e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 47.70  E-value: 1.21e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18640738  57 GDVSLVQELLDSGISV--------------DSNFQYGWTPLMYAASVANAELVRVLLDRGANA----SFEKDKQSILITA 118
Cdd:cd22192 100 QNLNLVRELIARGADVvspratgtffrpgpKNLIYYGEHPLSFAACVGNEEIVRLLIEHGADIraqdSLGNTVLHILVLQ 179

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 18640738 119 CSAHGSEEQIlkcvELLLSRNADPNVAC------RRLMTPIMYAARDGHTQVVALLV 169
Cdd:cd22192 180 PNKTFACQMY----DLILSYDKEDDLQPldlvpnNQGLTPFKLAAKEGNIVMFQHLV 232
SAM_1 pfam00536
SAM domain (Sterile alpha motif); It has been suggested that SAM is an evolutionarily ...
 282-333 5.93e-05

SAM domain (Sterile alpha motif); It has been suggested that SAM is an evolutionarily conserved protein binding domain that is involved in the regulation of numerous developmental processes in diverse eukaryotes. The SAM domain can potentially function as a protein interaction module through its ability to homo- and heterooligomerise with other SAM domains.


Pssm-ID: 425739  Cd Length: 64  Bit Score: 40.72  E-value: 5.93e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 18640738   282 FLHGLGLEHMTDLLKERDITLRHLLTMREDEFTKNGITSK-DQQKILAALKEL 333
Cdd:pfam00536  11 WLESIGLGQYIDSFRAGYIDGDALLQLTEDDLLKLGVTLLgHRKKILYAIQRL 63
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 78-104 1.41e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 38.72  E-value: 1.41e-04
                           10        20
                   ....*....|....*....|....*..
gi 18640738     78 YGWTPLMYAASVANAELVRVLLDRGAN 104
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGAD 27
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
53-234 3.23e-38

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 140.86  E-value: 3.23e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18640738  53 AMTIGDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILITACSAHGSEEqilkCV 132
Cdd:COG0666  61 AALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLE----IV 136

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18640738 133 ELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQT 212
Cdd:COG0666 137 KLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKD 216

                       170       180
                ....*....|....*....|..
gi 18640738 213 KDGKMPSEIAKRNKHHEIFNLL 234
Cdd:COG0666 217 NDGKTALDLAAENGNLEIVKLL 238
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
53-250 5.07e-38

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 140.47  E-value: 5.07e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18640738  53 AMTIGDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGA--NASfEKDKQSILITACsAHGSEEqilk 130
Cdd:COG0666  94 AARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGAdvNAQ-DNDGNTPLHLAA-ANGNLE---- 167

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18640738 131 CVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKML 210
Cdd:COG0666 168 IVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNA 247

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 18640738 211 QTKDGKMPSEIAKRNKHHEIFNLLSFTLNPLEGKLQQLTK 250
Cdd:COG0666 248 KDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLT 287
SAM_ASZ1 cd09521
SAM domain of ASZ1 subfamily; SAM (sterile alpha motif) domain of ASZ1 (Ankyrin, SAM, leucine ...
 272-334 1.90e-23

SAM domain of ASZ1 subfamily; SAM (sterile alpha motif) domain of ASZ1 (Ankyrin, SAM, leucine Zipper) also known as GASZ (Germ cell-specific Ankyrin, SAM, leucine Zipper) subfamily is a potential protein-protein interaction domain. Proteins of this group are involved in the repression of transposable elements during spermatogenesis, oogenesis, and preimplantation embryogenesis. They support synthesis of PIWI-interacting RNA via association with some PIWI proteins, such as MILI and MIWI. This association is required for initiation and maintenance of retrotransposon repression during the meiosis. In mice lacking ASZ1, DNA damage and delayed germ cell maturation was observed due to retrotransposons releasing from their repressed state.


Pssm-ID: 188920  Cd Length: 64  Bit Score: 93.12  E-value: 1.90e-23
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 18640738 272 SYTAFGDLEVFLHGLGLEHMTDLLKERDITLRHLLTMREDEFTKNGITS-KDQQKILAALKELQ 334
Cdd:cd09521   1 SYSKLDDLELFLHGLELGHLTPLFKEHDVTFSQLLKMTEEDLEKIGITQpGDQKKILDAIKEVH 64
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
59-234 2.97e-20

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 90.78  E-value: 2.97e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18640738  59 VSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILITACSAHGSEEQILkcveLLLSR 138
Cdd:COG0666   1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVAL----LLLAA 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18640738 139 NADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMP 218
Cdd:COG0666  77 GADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTP 156

                       170
                ....*....|....*.
gi 18640738 219 SEIAKRNKHHEIFNLL 234
Cdd:COG0666 157 LHLAAANGNLEIVKLL 172
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 59-281 3.13e-18

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 86.64  E-value: 3.13e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18640738   59 VSLVQELLDSGISVDSNFQYGWTPLMYAASV-----ANAELVRVLLDRGANASFEKDKQS----ILITACSAHgseeqiL 129
Cdd:PHA03100  48 IDVVKILLDNGADINSSTKNNSTPLHYLSNIkynltDVKEIVKLLLEYGANVNAPDNNGItpllYAISKKSNS------Y 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18640738  130 KCVELLLSRNADPNVACRRLMTPIMYAARDGH--TQVVALLVAHGAEVN----------------TQDENGYTALTWAAR 191
Cdd:PHA03100 122 SIVEYLLDNGANVNIKNSDGENLLHLYLESNKidLKILKLLIDKGVDINaknrvnyllsygvpinIKDVYGFTPLHYAVY 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18640738  192 QGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLLS---------------FTLNPLEGKLQQLTKEDTICK 256
Cdd:PHA03100 202 NNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLnngpsiktiietllyFKDKDLNTITKIKMLKKSIMY 281

                        250       260
                 ....*....|....*....|....*.
gi 18640738  257 ILTTDSDREKDH-IFSSYTAFGDLEV 281
Cdd:PHA03100 282 MFLLDPGFYKNRkLIENSKSLKDVIN 307
Ank_2 pfam12796
Ankyrin repeats (3 copies);
129-211 5.07e-18

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 79.00  E-value: 5.07e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18640738   129 LKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHgAEVNTQDeNGYTALTWAARQGHKNIVLKLLELGANK 208
Cdd:pfam12796  10 LELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVKLLLEKGADI 87


                  ...
gi 18640738   209 MLQ 211
Cdd:pfam12796  88 NVK 90
Ank_2 pfam12796
Ankyrin repeats (3 copies);
83-179 8.98e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 69.76  E-value: 8.98e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18640738    83 LMYAASVANAELVRVLLDRGANASF-EKDKQSILITACSaHGSEEqilkCVELLLSrNADPNVACRRlMTPIMYAARDGH 161
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLqDKNGRTALHLAAK-NGHLE----IVKLLLE-HADVNLKDNG-RTALHYAARSGH 73

                          90
                  ....*....|....*...
gi 18640738   162 TQVVALLVAHGAEVNTQD 179
Cdd:pfam12796  74 LEIVKLLLEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 58-232 2.93e-13

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 71.59  E-value: 2.93e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18640738   58 DVSLVQELLDSGISVDSNFQYGWTPL-MYAASV-ANAELVRVLLDRGANAsFEKD--KQSIL-ITACSAHGSEeqilKCV 132
Cdd:PHA03095 131 NPKVIRLLLRKGADVNALDLYGMTPLaVLLKSRnANVELLRLLIDAGADV-YAVDdrFRSLLhHHLQSFKPRA----RIV 205

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18640738  133 ELLLSRNADPNVACRRLMTPIMYAARDGHTQ--VVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKML 210
Cdd:PHA03095 206 RELIRAGCDPAATDMLGNTPLHSMATGSSCKrsLVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINA 285

                        170       180
                 ....*....|....*....|..
gi 18640738  211 QTKDGKMPSEIAKRNKHHEIFN 232
Cdd:PHA03095 286 VSSDGNTPLSLMVRNNNGRAVR 307
Ank_2 pfam12796
Ankyrin repeats (3 copies);
57-144 3.62e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 65.14  E-value: 3.62e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18640738    57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRgANASFEKDKQSILITACSaHGSEEqilkCVELLL 136
Cdd:pfam12796   8 GNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGRTALHYAAR-SGHLE----IVKLLL 81


                  ....*...
gi 18640738   137 SRNADPNV 144
Cdd:pfam12796  82 EKGADINV 89
Ank_2 pfam12796
Ankyrin repeats (3 copies);
153-234 2.27e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 62.83  E-value: 2.27e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18640738   153 IMYAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMlqTKDGKMPSEIAKRNKHHEIFN 232
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNL--KDNGRTALHYAARSGHLEIVK 78


                  ..
gi 18640738   233 LL 234
Cdd:pfam12796  79 LL 80
Ank_4 pfam13637
Ankyrin repeats (many copies);
150-202 7.26e-12

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 59.98  E-value: 7.26e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 18640738   150 MTPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLL 202
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 53-218 4.94e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 61.52  E-value: 4.94e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18640738   53 AMTIGDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASfekdkqsILITACSAHGSEEQILKCv 132
Cdd:PHA02874  42 AIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDTS-------ILPIPCIEKDMIKTILDC- 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18640738  133 elllsrNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQT 212
Cdd:PHA02874 114 ------GIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKD 187


                 ....*.
gi 18640738  213 KDGKMP 218
Cdd:PHA02874 188 NNGESP 193
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 53-207 7.44e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 60.78  E-value: 7.44e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18640738   53 AMTIGDVSLVQELLDSGISVDSNF-QYGWTPLMYAASVANAELVRVLLDRGANASFEK-DKQSILITACSAHGseeqiLK 130
Cdd:PHA02875  75 AVEEGDVKAVEELLDLGKFADDVFyKDGMTPLHLATILKKLDIMKLLIARGADPDIPNtDKFSPLHLAVMMGD-----IK 149

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 18640738  131 CVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDENG-YTALTWAARQGHKNIVLKLLELGAN 207
Cdd:PHA02875 150 GIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGcVAALCYAIENNKIDIVRLFIKRGAD 227
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 141-235 4.33e-09

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 58.76  E-value: 4.33e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18640738  141 DPNVAcRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSE 220
Cdd:PTZ00322  75 DPVVA-HMLTVELCQLAASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLE 153

                         90
                 ....*....|....*
gi 18640738  221 IAKRNKHHEIFNLLS 235
Cdd:PTZ00322 154 LAEENGFREVVQLLS 168
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 53-255 7.10e-09

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 58.34  E-value: 7.10e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18640738   53 AMTIGDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFeKDKQ--SILITACSA-HGSEEQIL 129
Cdd:PLN03192 532 VASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHI-RDANgnTALWNAISAkHHKIFRIL 610

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18640738  130 kcveLLLSRNADPNVACRRLMTpimyAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKM 209
Cdd:PLN03192 611 ----YHFASISDPHAAGDLLCT----AAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVD 682

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 18640738  210 LQTKDGKMPSE-----IAKRNKHHEIFNLLSFTLNPLEGKLQQLTKEDTIC 255
Cdd:PLN03192 683 KANTDDDFSPTelrelLQKRELGHSITIVDSVPADEPDLGRDGGSRPGRLQ 733
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 65-207 7.26e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 58.15  E-value: 7.26e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18640738   65 LLDSGISVDSNFQYGWTPLMYAASVAN-AELVRVLLDRGA--NASFEKDKQSILITACSAHGSEEqilkcVELLLSRNAD 141
Cdd:PHA02876 259 LYDAGFSVNSIDDCKNTPLHHASQAPSlSRLVPKLLERGAdvNAKNIKGETPLYLMAKNGYDTEN-----IRTLIMLGAD 333

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 18640738  142 PNVACRRLMTPIMYAAR-DGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGAN 207
Cdd:PHA02876 334 VNAADRLYITPLHQASTlDRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGAD 400
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 53-207 7.76e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 57.69  E-value: 7.76e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18640738   53 AMTIGDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGA----------------------------- 103
Cdd:PHA02875   9 AILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAipdvkypdieselhdaveegdvkaveell 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18640738  104 ------NASFEKDKQSILITAcsahgSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNT 177
Cdd:PHA02875  89 dlgkfaDDVFYKDGMTPLHLA-----TILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDI 163

                        170       180       190
                 ....*....|....*....|....*....|
gi 18640738  178 QDENGYTALTWAARQGHKNIVLKLLELGAN 207
Cdd:PHA02875 164 EDCCGCTPLIIAMAKGDIAICKMLLDSGAN 193
Ank_5 pfam13857
Ankyrin repeats (many copies);
134-186 3.76e-08

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 49.65  E-value: 3.76e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 18640738   134 LLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTAL 186
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 53-154 4.83e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 55.00  E-value: 4.83e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18640738   53 AMTIGDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFeKDKQSILITACSAhgSEEQILKCV 132
Cdd:PHA02875 142 AVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDY-FGKNGCVAALCYA--IENNKIDIV 218

                         90       100
                 ....*....|....*....|..
gi 18640738  133 ELLLSRNADPNVacrrlMTPIM 154
Cdd:PHA02875 219 RLFIKRGADCNI-----MFMIE 235
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 61-218 8.51e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 54.20  E-value: 8.51e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18640738   61 LVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILITACSAHGSEEQIlkcvELLLSRNA 140
Cdd:PHA02874 106 MIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDII----KLLLEKGA 181

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 18640738  141 DPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARqgHKNIVLKLLELGANKMLQTKDGKMP 218
Cdd:PHA02874 182 YANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAII--HNRSAIELLINNASINDQDIDGSTP 257
Ank_5 pfam13857
Ankyrin repeats (many copies);
168-222 8.64e-08

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 48.50  E-value: 8.64e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 18640738   168 LVAHG-AEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIA 222
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA03095 PHA03095
ankyrin-like protein; Provisional
 87-207 1.30e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 53.88  E-value: 1.30e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18640738   87 ASVANAELVRVLLDRGANASFEKDKQSILITACsAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHT-QVV 165
Cdd:PHA03095  22 ASNVTVEEVRRLLAAGADVNFRGEYGKTPLHLY-LHYSSEKVKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATTlDVI 100

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 18640738  166 ALLVAHGAEVNTQDENGYTAL-TWAARQG-HKNIVLKLLELGAN 207
Cdd:PHA03095 101 KLLIKAGADVNAKDKVGRTPLhVYLSGFNiNPKVIRLLLRKGAD 144
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 57-234 2.60e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 52.66  E-value: 2.60e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18640738   57 GDVSLVQELLDS-----GISVDSNFqygwTPLMYAASVANAELVRVLLDRGANASFEKDK-QSILITACSAHGSeeqilK 130
Cdd:PHA02874  12 GDIEAIEKIIKNkgnciNISVDETT----TPLIDAIRSGDAKIVELFIKHGADINHINTKiPHPLLTAIKIGAH-----D 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18640738  131 CVELLLSRNADPNVacrrLMTPimyaarDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKML 210
Cdd:PHA02874  83 IIKLLIDNGVDTSI----LPIP------CIEKDMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNI 152

                        170       180
                 ....*....|....*....|....
gi 18640738  211 QTKDGKMPSEIAKRNKHHEIFNLL 234
Cdd:PHA02874 153 EDDNGCYPIHIAIKHNFFDIIKLL 176
SAM_superfamily cd09487
SAM (Sterile alpha motif ); SAM (Sterile Alpha Motif) domain is a module consisting of ...
 278-332 2.63e-07

SAM (Sterile alpha motif ); SAM (Sterile Alpha Motif) domain is a module consisting of approximately 70 amino acids. This domain is found in the Fungi/Metazoa group and in a restricted number of bacteria. Proteins with SAM domains are represented by a wide variety of domain architectures and have different intracellular localization, including nucleus, cytoplasm and membranes. SAM domains have diverse functions. They can interact with proteins, RNAs and membrane lipids, contain site of phosphorylation and/or kinase docking site, and play a role in protein homo and hetero dimerization/oligomerization in processes ranging from signal transduction to regulation of transcription. Mutations in SAM domains have been linked to several diseases.


Pssm-ID: 188886 [Multi-domain]  Cd Length: 56  Bit Score: 47.23  E-value: 2.63e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 18640738 278 DLEVFLHGLGLEHMTDLLKERDITLRHLLTMREDEFTKNGITSK-DQQKILAALKE 332
Cdd:cd09487   1 DVAEWLESLGLEQYADLFRKNEIDGDALLLLTDEDLKELGITSPgHRKKILRAIQR 56
PHA03095 PHA03095
ankyrin-like protein; Provisional
 58-204 1.96e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 50.02  E-value: 1.96e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18640738   58 DVSLVQELLDSGISVDSNFQYGWTPL---MYAASVANAELVRVLLDRGANASfekdkqsiLITACSA--------HGSEE 126
Cdd:PHA03095  26 TVEEVRRLLAAGADVNFRGEYGKTPLhlyLHYSSEKVKDIVRLLLEAGADVN--------APERCGFtplhlylyNATTL 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18640738  127 QILKcveLLLSRNADPNVACRRLMTPI-MYAARDG-HTQVVALLVAHGAEVNTQDENGYTALtwAARQGHKNIVLKLLEL 204
Cdd:PHA03095  98 DVIK---LLIKAGADVNAKDKVGRTPLhVYLSGFNiNPKVIRLLLRKGADVNALDLYGMTPL--AVLLKSRNANVELLRL 172
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 58-234 3.41e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 49.68  E-value: 3.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18640738   58 DVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANAS-----------FEKDKQSI------------ 114
Cdd:PHA02876 157 ELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNiialddlsvleCAVDSKNIdtikaiidnrsn 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18640738  115 -------LITACSAHGSEEQIL-----------------------------KCVELLLSRNADPNVACRRLMTPIMYAAR 158
Cdd:PHA02876 237 inkndlsLLKAIRNEDLETSLLlydagfsvnsiddckntplhhasqapslsRLVPKLLERGADVNAKNIKGETPLYLMAK 316

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 18640738  159 DGH-TQVVALLVAHGAEVNTQDENGYTALTWAAR-QGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLL 234
Cdd:PHA02876 317 NGYdTENIRTLIMLGADVNAADRLYITPLHQASTlDRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTL 394
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 61-218 5.79e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 48.42  E-value: 5.79e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18640738   61 LVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFE-KDKQSILITACSAHGSeeqilkCVELLLSrN 139
Cdd:PHA02874 172 IIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKcKNGFTPLHNAIIHNRS------AIELLIN-N 244

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18640738  140 ADPNVACRRLMTPIMYAAR-DGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKllELGANKMLQTKDGKMP 218
Cdd:PHA02874 245 ASINDQDIDGSTPLHHAINpPCDIDIIDILLYHKADISIKDNKGENPIDTAFKYINKDPVIK--DIIANAVLIKEADKLK 322
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 97-234 6.02e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 48.72  E-value: 6.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18640738   97 VLLDRganasFEKDKQSILITACSAHGSEEQILKCVELLLSRNADPNVACR-RLMTPIMYAARDGHTQVVALLVAHGAEV 175
Cdd:PHA02878 120 ILTNR-----YKNIQTIDLVYIDKKSKDDIIEAEITKLLLSYGADINMKDRhKGNTALHYATENKDQRLTELLLSYGANV 194

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 18640738  176 NTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIA-KRNKHHEIFNLL 234
Cdd:PHA02878 195 NIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISvGYCKDYDILKLL 254
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 57-169 1.21e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 47.70  E-value: 1.21e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18640738  57 GDVSLVQELLDSGISV--------------DSNFQYGWTPLMYAASVANAELVRVLLDRGANA----SFEKDKQSILITA 118
Cdd:cd22192 100 QNLNLVRELIARGADVvspratgtffrpgpKNLIYYGEHPLSFAACVGNEEIVRLLIEHGADIraqdSLGNTVLHILVLQ 179

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 18640738 119 CSAHGSEEQIlkcvELLLSRNADPNVAC------RRLMTPIMYAARDGHTQVVALLV 169
Cdd:cd22192 180 PNKTFACQMY----DLILSYDKEDDLQPldlvpnNQGLTPFKLAAKEGNIVMFQHLV 232
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 102-189 1.42e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 47.75  E-value: 1.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18640738  102 GANASFEKDKQSILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDEN 181
Cdd:PHA02876 131 GNDIHYDKINESIEYMKLIKERIQQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALD 210


                 ....*...
gi 18640738  182 GYTALTWA 189
Cdd:PHA02876 211 DLSVLECA 218
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 61-199 2.72e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 46.60  E-value: 2.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18640738   61 LVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANasFEKDKQSI-LITACSAHGSEEQIlkCVELLLSRN 139
Cdd:PHA02876 357 IVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGAD--IEALSQKIgTALHFALCGTNPYM--SVKTLIDRG 432

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 18640738  140 ADPNVACRRLMTPIMYAARDG-HTQVVALLVAHGAEVNTQD-ENGYTALTWAARQGHKNIVL 199
Cdd:PHA02876 433 ANVNSKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVNAINiQNQYPLLIALEYHGIVNILL 494
SAM_1 pfam00536
SAM domain (Sterile alpha motif); It has been suggested that SAM is an evolutionarily ...
 282-333 5.93e-05

SAM domain (Sterile alpha motif); It has been suggested that SAM is an evolutionarily conserved protein binding domain that is involved in the regulation of numerous developmental processes in diverse eukaryotes. The SAM domain can potentially function as a protein interaction module through its ability to homo- and heterooligomerise with other SAM domains.


Pssm-ID: 425739  Cd Length: 64  Bit Score: 40.72  E-value: 5.93e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 18640738   282 FLHGLGLEHMTDLLKERDITLRHLLTMREDEFTKNGITSK-DQQKILAALKEL 333
Cdd:pfam00536  11 WLESIGLGQYIDSFRAGYIDGDALLQLTEDDLLKLGVTLLgHRKKILYAIQRL 63
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 78-104 1.41e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 38.72  E-value: 1.41e-04
                           10        20
                   ....*....|....*....|....*..
gi 18640738     78 YGWTPLMYAASVANAELVRVLLDRGAN 104
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGAD 27
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 78-104 2.78e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 38.01  E-value: 2.78e-04
                          10        20
                  ....*....|....*....|....*..
gi 18640738    78 YGWTPLMYAASVANAELVRVLLDRGAN 104
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGAD 27
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 150-180 3.28e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 38.04  E-value: 3.28e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 18640738   150 MTPIMYAA-RDGHTQVVALLVAHGAEVNTQDE 180
Cdd:pfam00023   3 NTPLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 139-234 7.09e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 42.16  E-value: 7.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18640738  139 NADPNVACRrlmtpIMYAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMP 218
Cdd:PLN03192 520 HDDPNMASN-----LLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTA 594

                         90
                 ....*....|....*.
gi 18640738  219 SEIAKRNKHHEIFNLL 234
Cdd:PLN03192 595 LWNAISAKHHKIFRIL 610
SAM_ANKS3 cd09519
SAM domain of ANKS3 subfamily; SAM (sterile alpha motif) domain of ANKS3 subfamily is a ...
 273-319 7.96e-04

SAM domain of ANKS3 subfamily; SAM (sterile alpha motif) domain of ANKS3 subfamily is a potential protein-protein interaction domain. Proteins of this subfamily have N-terminal ankyrin repeats and a C-terminal SAM domain. SAM is a widespread domain in signaling proteins. In many cases it mediates homo-dimerization/oligomerization.


Pssm-ID: 188918  Cd Length: 64  Bit Score: 37.86  E-value: 7.96e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 18640738 273 YTAFGDLEVFLHGLGLEHMTDLLKERDITLRHLLTMREDEFTKNGIT 319
Cdd:cd09519   1 YTGPKDLSELLEQIGCSKYLPIFEEQDIDLRIFLTLTESDLKEIGIT 47
Ank_4 pfam13637
Ankyrin repeats (many copies);
115-169 1.14e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.87  E-value: 1.14e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 18640738   115 LITACSAHGSEEqilkCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLV 169
Cdd:pfam13637   4 ALHAAAASGHLE----LLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 181-207 1.27e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.03  E-value: 1.27e-03
                           10        20
                   ....*....|....*....|....*..
gi 18640738    181 NGYTALTWAARQGHKNIVLKLLELGAN 207
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGAD 27
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 78-104 1.31e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 36.11  E-value: 1.31e-03
                          10        20
                  ....*....|....*....|....*...
gi 18640738    78 YGWTPLMYAA-SVANAELVRVLLDRGAN 104
Cdd:pfam00023   1 DGNTPLHLAAgRRGNLEIVKLLLSKGAD 28
Ank_4 pfam13637
Ankyrin repeats (many copies);
57-99 2.00e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.48  E-value: 2.00e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 18640738    57 GDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLL 99
Cdd:pfam13637  12 GHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 150-176 3.24e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.87  E-value: 3.24e-03
                           10        20
                   ....*....|....*....|....*..
gi 18640738    150 MTPIMYAARDGHTQVVALLVAHGAEVN 176
Cdd:smart00248   3 RTPLHLAAENGNLEVVKLLLDKGADIN 29
PHA02946 PHA02946
ankyin-like protein; Provisional
 58-262 5.07e-03

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 39.27  E-value: 5.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18640738   58 DVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGA--NASFEKDKQSILITAcsahGSEEQILKCVELL 135
Cdd:PHA02946  51 DERFVEELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGAdpNACDKQHKTPLYYLS----GTDDEVIERINLL 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18640738  136 LSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTAL--TWAARQGHKNIVLKLLELGANKMLQTK 213
Cdd:PHA02946 127 VQYGAKINNSVDEEGCGPLLACTDPSERVFKKIMSIGFEARIVDKFGKNHIhrHLMSDNPKASTISWMMKLGISPSKPDH 206

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 18640738  214 DGKMPSEI--AKRNKHHEIFNLL----------SFTLNPLEGKLQQLTKEDTICKILTTDS 262
Cdd:PHA02946 207 DGNTPLHIvcSKTVKNVDIINLLlpstdvnkqnKFGDSPLTLLIKTLSPAHLINKLLSTSN 267
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 81-158 5.12e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 38.81  E-value: 5.12e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 18640738   81 TPLMYAASVANAELVRVLLDRGANASFEKDKQSILITACSA-HGSeeqiLKCVELLLSRNADPNVACRRLMTPIMYAAR 158
Cdd:PHA02884  72 NPLIYAIDCDNDDAAKLLIRYGADVNRYAEEAKITPLYISVlHGC----LKCLEILLSYGADINIQTNDMVTPIELALM 146
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 95-182 6.41e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 39.11  E-value: 6.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18640738   95 VRVLLDRGANA-SFEKDKQSILITACsAHGSeeqiLKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGA 173
Cdd:PTZ00322  98 ARILLTGGADPnCRDYDGRTPLHIAC-ANGH----VQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQ 172


                 ....*....
gi 18640738  174 EVNTQDENG 182
Cdd:PTZ00322 173 CHFELGANA 181
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 150-177 6.52e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 34.16  E-value: 6.52e-03
                          10        20
                  ....*....|....*....|....*...
gi 18640738   150 MTPIMYAARDGHTQVVALLVAHGAEVNT 177
Cdd:pfam13606   3 NTPLHLAARNGRLEIVKLLLENGADINA 30
Ank_5 pfam13857
Ankyrin repeats (many copies);
65-105 7.28e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 34.63  E-value: 7.28e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 18640738    65 LLDSG-ISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANA 105
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDL 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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