NCBI Conserved Domain Search

Conserved domains on [gi|18859185|ref|NP_571158|]

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odorant receptor 115-15 [Danio rerio]

Protein Classification

G protein-coupled receptor family protein( domain architecture ID 705710)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters

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List of domain hits

Name

Accession

Description

Interval

E-value

7tm_GPCRs super family

cl28897

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...

25-290

2.06e-56

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.

The actual alignment was detected with superfamily member cd13954:

Pssm-ID: 475119 [Multi-domain] Cd Length: 270 Bit Score: 183.45 E-value: 2.06e-56

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  25 PVFVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILksPSQRYISYVECVVQAFS 104
Cdd:cd13954   2 LLFVLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLL--SGDKTISFSGCLTQLYF 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 105 THTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRCRT-FISNPFCDNAS 183
Cdd:cd13954  80 FFSLGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSnVINHFFCDIPP 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 184 LFKLSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSLYLIMLISGLIIIVLHR 263
Cdd:cd13954 160 LLKLSCSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPS 239

                       250       260
                ....*....|....*....|....*..
gi 18859185 264 FPAYSDYRKIASLLFHIIPSILNPIIY 290
Cdd:cd13954 240 SSYSSDLDKVVSVFYTVVTPMLNPIIY 266

Name

Accession

Description

Interval

E-value

7tmA_OR

cd13954

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...

25-290

2.06e-56

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320092 [Multi-domain] Cd Length: 270 Bit Score: 183.45 E-value: 2.06e-56

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  25 PVFVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILksPSQRYISYVECVVQAFS 104
Cdd:cd13954   2 LLFVLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLL--SGDKTISFSGCLTQLYF 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 105 THTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRCRT-FISNPFCDNAS 183
Cdd:cd13954  80 FFSLGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSnVINHFFCDIPP 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 184 LFKLSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSLYLIMLISGLIIIVLHR 263
Cdd:cd13954 160 LLKLSCSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPS 239

                       250       260
                ....*....|....*....|....*..
gi 18859185 264 FPAYSDYRKIASLLFHIIPSILNPIIY 290
Cdd:cd13954 240 SSYSSDLDKVVSVFYTVVTPMLNPIIY 266

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

30-306

1.61e-33

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 124.15 E-value: 1.61e-33

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185    30 FLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKSpsQRYISYVECVVQAFSTHTYG 109
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFG--LREISFEACLTQMFFIHKFS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185   110 TTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRC-RTFISNPFCDNASLFKLS 188
Cdd:pfam13853  79 IMESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCgHHVLSHSYCLHMGLARLS 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185   189 CEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSLYLIMLISGLIIIVLHRFPAYS 268
Cdd:pfam13853 159 CADIKVNNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGHNV 238

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 18859185   269 DY--RKIASLLFHIIPSILNPIIYGVQSSEVRHVLIQVLS 306
Cdd:pfam13853 239 PPllQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRMLL 278

Name

Accession

Description

Interval

E-value

7tmA_OR

cd13954

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...

25-290

2.06e-56

Pssm-ID: 320092 [Multi-domain] Cd Length: 270 Bit Score: 183.45 E-value: 2.06e-56

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  25 PVFVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILksPSQRYISYVECVVQAFS 104
Cdd:cd13954   2 LLFVLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLL--SGDKTISFSGCLTQLYF 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 105 THTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRCRT-FISNPFCDNAS 183
Cdd:cd13954  80 FFSLGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSnVINHFFCDIPP 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 184 LFKLSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSLYLIMLISGLIIIVLHR 263
Cdd:cd13954 160 LLKLSCSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPS 239

                       250       260
                ....*....|....*....|....*..
gi 18859185 264 FPAYSDYRKIASLLFHIIPSILNPIIY 290
Cdd:cd13954 240 SSYSSDLDKVVSVFYTVVTPMLNPIIY 266

7tmA_OR56-like

cd15223

olfactory receptor family 56 and related proteins, member of the class A family of ...

30-298

8.59e-53

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320351 [Multi-domain] Cd Length: 279 Bit Score: 174.40 E-value: 8.59e-53

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  30 FLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKSPSQryISYVECVVQAFSTHTYG 109
Cdd:cd15223   7 FLLLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANT--ISLPGCFAQMFFIHFFT 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 110 TTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRC-RTFISNPFCDNASLFKLS 188
Cdd:cd15223  85 AMESSILLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCsSNVIEHCYCDHMALVSLA 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 189 CEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSLYLIMLISGLIIIVLHRF--PA 266
Cdd:cd15223 165 CGDTTINSIYGLAVAWLIVGSDIILIFFSYALILRAVLRLASGEARSKALNTCGSHLIVILFFYTAVLVSSLTYRFgkTI 244

                       250       260       270
                ....*....|....*....|....*....|..
gi 18859185 267 YSDYRKIASLLFHIIPSILNPIIYGVQSSEVR 298
Cdd:cd15223 245 PPDVHVLLSVLYILIPPALNPIIYGVRTKEIR 276

7tmA_OR5H-like

cd15409

olfactory receptor subfamily 5H and related proteins, member of the class A family of ...

25-301

8.69e-51

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320531 [Multi-domain] Cd Length: 279 Bit Score: 169.51 E-value: 8.69e-51

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  25 PVFVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKSpsQRYISYVECVVQAFS 104
Cdd:cd15409   2 PLFLVFLAIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSK--NKMISFSGCAAQFFF 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 105 THTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRCRT-FISNPFCDNAS 183
Cdd:cd15409  80 FGFSATTECFLLAAMAYDRYVAICNPLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSnEINHFFCDIPP 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 184 LFKLSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSLYLIMLISGLIIIVLHR 263
Cdd:cd15409 160 LLKISCTDPSINELVLFIFSGSIQVFTILTVLISYSYILFTILKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPS 239

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 18859185 264 FPAYSDYRKIASLLFHIIPSILNPIIYGVQSSEVRHVL 301
Cdd:cd15409 240 SLYALDQDMMDSLFYTIVIPLLNPFIYSLRNKEVIDAL 277

7tmA_OR52P-like

cd15953

olfactory receptor subfamily 52P and related proteins, member of the class A family of ...

30-297

9.99e-51

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341354 Cd Length: 275 Bit Score: 168.98 E-value: 9.99e-51

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  30 FLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKSpsQRYISYVECVVQAFSTHTYG 109
Cdd:cd15953   7 FCLMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFN--LKEITFSGCLTQMFFIHTLS 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 110 TTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRCRT-FISNPFCDNASLFKLS 188
Cdd:cd15953  85 IMESAVLVAMAFDRYVAICNPLRYATILTNSRIAKLGLVGLIRGVLLILPLPLLLSRLPFCANrIIPHTYCEHMAVVKLA 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 189 CEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSLYLIMLISGLIIIVLHRF---- 264
Cdd:cd15953 165 CGDTTINRIYGLVVALLVVGLDLLLIALSYALIIRAVLRLSSKKARQKALNTCTAHICVILMSYTPALFSFLTHRFgqgi 244

                       250       260       270
                ....*....|....*....|....*....|...
gi 18859185 265 PAYSDYrkIASLLFHIIPSILNPIIYGVQSSEV 297
Cdd:cd15953 245 APHIHI--ILANLYLLVPPMLNPIIYGVKTKEI 275

7tmA_OR51_52-like

cd15917

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...

27-297

1.18e-50

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341351 Cd Length: 275 Bit Score: 169.01 E-value: 1.18e-50

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  27 FVFFLLFYVAImVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKSPsqRYISYVECVVQAFSTH 106
Cdd:cd15917   5 IPFCAMYLVAL-LGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNA--REISFDACLAQMFFIH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 107 TYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRCRT-FISNPFCDNASLF 185
Cdd:cd15917  82 SFTAMESGVLLAMAFDRYVAICYPLRYTTILTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYCGSnVISHSYCEHMAVV 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 186 KLSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSLYLIMLISGLIIIVLHRF- 264
Cdd:cd15917 162 KLACGDTRVNSIYGLFVALLIVGFDLLFIALSYVLILRAVLQLPSKEARLKALSTCGSHICVILIFYTPALFSFLTHRFg 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 18859185 265 ---PAYsdYRKIASLLFHIIPSILNPIIYGVQSSEV 297
Cdd:cd15917 242 hhvPPH--VHILLANLYLLLPPMLNPIVYGVRTKQI 275

7tmA_OR14-like

cd15227

olfactory receptor family 14 and related proteins, member of the class A family of ...

27-290

3.91e-47

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320355 Cd Length: 270 Bit Score: 159.54 E-value: 3.91e-47

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  27 FVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKSPsqRYISYVECVVQAFSTH 106
Cdd:cd15227   4 FVLFLLIYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNT--RSISFLGCVAQVFLFI 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 107 TYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRCR-TFISNPFCDNASLF 185
Cdd:cd15227  82 FFAASELALLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGALHTANTFSLPFCGsNVIHQFFCDIPQLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 186 KLSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSLYLIMLISGLIiivlhrfp 265
Cdd:cd15227 162 KLSCSDTYLNEIGVLVLSVCLGLGCFVFIIVSYVHIFSTVLRIPSAQGRSKAFSTCLPHLIVVSLFLSTGSF-------- 233

                       250       260       270
                ....*....|....*....|....*....|...
gi 18859185 266 AY--------SDYRKIASLLFHIIPSILNPIIY 290
Cdd:cd15227 234 AYlkppsdspSLLDLLLSVFYSVVPPTLNPIIY 266

7tmA_OR5AK3-like

cd15408

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...

13-298

5.12e-47

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320530 Cd Length: 287 Bit Score: 159.79 E-value: 5.12e-47

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  13 LEGLRVSEEATYPVFVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKSpsQRY 92
Cdd:cd15408   3 LLGFTDQPELQVLLFVVFLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAE--RKV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  93 ISYVECVVQAFSTHTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRCRT 172
Cdd:cd15408  81 ISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVCVSLVAGSYLAGFLNSTVHTGFILRLSFCGS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 173 FISNPF-CDNASLFKLSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSLYLIM 251
Cdd:cd15408 161 NVINHFfCDGPPLLALSCSDTSLNEMLLFAFVGFNVLTTTLVILISYTYILATILRMRSAEGRHKAFSTCASHLTAVTLF 240

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 18859185 252 LISGLIIIVLHRFPAYSDYRKIASLLFHIIPSILNPIIYGVQSSEVR 298
Cdd:cd15408 241 YGSLAFMYLRPSSRYSLDLDKVASVFYTVVIPMLNPLIYSLRNKEVK 287

7tmA_OR6C-like

cd15912

olfactory receptor subfamily 6C and related proteins, member of the class A family of ...

26-290

6.35e-46

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320578 Cd Length: 270 Bit Score: 156.49 E-value: 6.35e-46

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  26 VFVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKSpsQRYISYVECVVQAFST 105
Cdd:cd15912   3 LFLLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSG--KKTISFAGCFAQSFFY 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 106 HTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRCRTFISNPF-CDNASL 184
Cdd:cd15912  81 FFLGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFfCDSGPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 185 FKLSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSLYLIMLISGLIIIVLHRF 264
Cdd:cd15912 161 LKLSCSDTRLIELLDFILASVVLLGSLLLTIVSYIYIISTILRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPSQ 240

                       250       260
                ....*....|....*....|....*.
gi 18859185 265 PAYSDYRKIASLLFHIIPSILNPIIY 290
Cdd:cd15912 241 SSSLDLNKVVALLNTVVTPLLNPFIY 266

7tmA_OR52B-like

cd15221

olfactory receptor subfamily 52B and related proteins, member of the class A family of ...

30-297

9.14e-46

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320349 Cd Length: 275 Bit Score: 156.30 E-value: 9.14e-46

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  30 FLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMdILKSPSQRyISYVECVVQAFSTHTYG 109
Cdd:cd15221   7 FCSMYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLA-IFWFGAGE-ISFDGCLTQMFFVHFVF 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 110 TTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRCRT-FISNPFCDNASLFKLS 188
Cdd:cd15221  85 VTESAILLAMAFDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFCIVFPFVFLLKRLPYCGHnVIPHTYCEHMGIARLA 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 189 CEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSLYLIMLISGLIIIVLHRFPAY- 267
Cdd:cd15221 165 CADITVNIWYGLTVALLTVGLDVVLIAVSYALILRAVFRLPSKDARLKALSTCGSHVCVILMFYTPAFFSFLTHRFGRHi 244

                       250       260       270
                ....*....|....*....|....*....|.
gi 18859185 268 -SDYRKIASLLFHIIPSILNPIIYGVQSSEV 297
Cdd:cd15221 245 pRHVHILLANLYVLVPPMLNPIVYGVKTKQI 275

7tmA_OR5-like

cd15230

olfactory receptor family 5 and related proteins, member of the class A family of ...

25-290

2.53e-45

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320358 Cd Length: 270 Bit Score: 154.97 E-value: 2.53e-45

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  25 PVFVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKSpsQRYISYVECVVQAFS 104
Cdd:cd15230   2 PLFVLFLLIYLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSE--KKTISFAGCAAQFFF 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 105 THTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRCRT-FISNPFCDNAS 183
Cdd:cd15230  80 FAVFGTTECFLLAAMAYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSnVINHFFCDIPP 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 184 LFKLSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSLyLIMLISGLIIIVLHR 263
Cdd:cd15230 160 LLKLSCSDTHINELVLFAFSGFIGLSTLLIILISYLYILITILRIRSAEGRRKAFSTCASHLTA-VSLFYGTLIFMYLRP 238

                       250       260
                ....*....|....*....|....*...
gi 18859185 264 FPAYS-DYRKIASLLFHIIPSILNPIIY 290
Cdd:cd15230 239 SSSYSlDQDKVVSVFYTVVIPMLNPLIY 266

7tmA_OR8S1-like

cd15229

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...

24-301

2.71e-45

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320357 [Multi-domain] Cd Length: 277 Bit Score: 155.06 E-value: 2.71e-45

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  24 YPVFVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKSpsQRYISYVECVVQAF 103
Cdd:cd15229   1 IFLFLVFLVIYLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSE--RKTISVEGCIAQIF 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 104 STHTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRCRT-FISNPFCDNA 182
Cdd:cd15229  79 FFFFFAGTEAFLLSAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGPnEINHFSCELP 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 183 SLFKLSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSLYLIMLISGLIIIVLH 262
Cdd:cd15229 159 SLLPLSCSDTFANKMVLLTSSVIFGLGSFLLTLVSYIHIISTILRIRSAEGRSKAFSTCSSHLTVVGLFYGTGFFRYLRP 238

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 18859185 263 RFPAYSDYRKIASLLFHIIPSILNPIIYGVQSSEVRHVL 301
Cdd:cd15229 239 NSASSSVLDRVFSIQYSILTPMLNPIIYSLKNKEVKAAL 277

7tmA_OR10A-like

cd15225

olfactory receptor subfamily 10A and related proteins, member of the class A family of ...

27-298

3.33e-45

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320353 Cd Length: 277 Bit Score: 154.92 E-value: 3.33e-45

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  27 FVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKSpsQRYISYVECVVQAFSTH 106
Cdd:cd15225   4 FVVFLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSE--DKTISFLGCATQMFFFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 107 TYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRCRTF-ISNPFCDNASLF 185
Cdd:cd15225  82 FLGGTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNeINHFFCDIPPVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 186 KLSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSLYLIMLISGLIIIVLHRFP 265
Cdd:cd15225 162 KLACADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKSS 241

                       250       260       270
                ....*....|....*....|....*....|...
gi 18859185 266 AYSDYRKIASLLFHIIPSILNPIIYGVQSSEVR 298
Cdd:cd15225 242 YSPETDKLLSLFYTVVTPMLNPIIYSLRNKEVK 274

7tmA_OR52I-like

cd15950

olfactory receptor subfamily 52I and related proteins, member of the class A family of ...

30-297

8.57e-45

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320616 Cd Length: 275 Bit Score: 153.72 E-value: 8.57e-45

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  30 FLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLmDILKSPSqRYISYVECVVQAFSTHTYG 109
Cdd:cd15950   7 FCSMYVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKML-SIFWLGS-AEISFEACFTQMFFVHSFT 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 110 TTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRCRT-FISNPFCDNASLFKLS 188
Cdd:cd15950  85 AVESGVLLAMAFDRYVAICHPLRYSAILTSQVIAQIGLAIVLRALLFMTPLTCLVTSLPYCGSrVVPHSYCEHMAVVKLA 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 189 CEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSLYLIMLISGLIIIVLHRFPAY- 267
Cdd:cd15950 165 CADPRPSSLYSITGSTLVVGTDSAFIAVSYGLILRAVLGLSSKEARLKAFSTCGSHVCVILLFYIPGLLSIYTQRFGQGv 244

                       250       260       270
                ....*....|....*....|....*....|.
gi 18859185 268 -SDYRKIASLLFHIIPSILNPIIYGVQSSEV 297
Cdd:cd15950 245 pPHTQVLLADLYLLVPPMLNPIIYGMRTKQI 275

7tmA_OR2A-like

cd15420

olfactory receptor subfamily 2A and related proteins, member of the class A family of ...

27-301

4.69e-44

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320542 [Multi-domain] Cd Length: 277 Bit Score: 151.71 E-value: 4.69e-44

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  27 FVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKSpsQRYISYVECVVQAFSTH 106
Cdd:cd15420   4 FGLFSLLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQ--RKTISFAGCGTQMYLFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 107 TYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRC-RTFISNPFCDNASLF 185
Cdd:cd15420  82 ALAHTECVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCgPNEVNHFFCEILAVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 186 KLSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSlyLIMLISGLIIIVLHRfP 265
Cdd:cd15420 162 KLACADTWINEILIFAGCVFILLGPFSLILISYLHILAAILKIQSAEGRRKAFSTCSSHLC--VVGLFYGTAMFMYMV-P 238

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 18859185 266 AYS---DYRKIASLLFHIIPSILNPIIYGVQSSEVRHVL 301
Cdd:cd15420 239 GSSnsaEQEKILSLFYSLFNPMLNPLIYSLRNKQVKGAL 277

7tmA_OR52R_52L-like

cd15951

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...

30-297

8.68e-44

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320617 Cd Length: 275 Bit Score: 150.96 E-value: 8.68e-44

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  30 FLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKSpsQRYISYVECVVQAFSTHTYG 109
Cdd:cd15951   7 FCIMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFN--SREIDFSACLTQMFFIHSFS 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 110 TTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRCRT-FISNPFCDNASLFKLS 188
Cdd:cd15951  85 TMESGIFVAMALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTnIIPHTYCEHMAVVKLA 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 189 CEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSLYLIMLISGLIIIVLHRFP--- 265
Cdd:cd15951 165 CADTRVSRAYGLSVAFLVGGLDVIFIAVSYIQILRAVFKLPSKEARLKTFGTCGSHICVILVFYIPALFSFLTHRFGhnv 244

                       250       260       270
                ....*....|....*....|....*....|..
gi 18859185 266 AYSDYRKIASlLFHIIPSILNPIIYGVQSSEV 297
Cdd:cd15951 245 PPHVHILIAN-VYLLVPPMLNPIIYGVRTKQI 275

7tmA_OR13-like

cd15232

olfactory receptor family 13 and related proteins, member of the class A family of ...

25-290

3.63e-43

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320360 [Multi-domain] Cd Length: 270 Bit Score: 149.33 E-value: 3.63e-43

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  25 PVFVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKSPSQryISYVECVVQAFS 104
Cdd:cd15232   2 LLFWLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKT--ISFGGCMAQLYF 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 105 THTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRCRTFISNPF-CDNAS 183
Cdd:cd15232  80 FTWSLGSELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFfCEIPP 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 184 LFKLSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLsLYLIMLISGLIIIVLHR 263
Cdd:cd15232 160 LLLLSCSDTSLNEIMAFVADVFFGVGNFLLTLTSYGFIIRSILRIRSTEGKKKAFSTCSSHL-IVVSLYYSTVIYTYIRP 238

                       250       260
                ....*....|....*....|....*...
gi 18859185 264 FPAYS-DYRKIASLLFHIIPSILNPIIY 290
Cdd:cd15232 239 SSSYSpEKDKVVAVLYSVVTPTLNPLIY 266

7tmA_OR5D-like

cd15410

olfactory receptor subfamily 5D and related proteins, member of the class A family of ...

25-298

1.66e-42

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320532 Cd Length: 294 Bit Score: 148.19 E-value: 1.66e-42

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  25 PVFVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKSpsQRYISYVECVVQAFS 104
Cdd:cd15410  15 PLFLVFLAIYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAE--DKAISYSGCMLQFFF 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 105 THTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRCR-TFISNPFCDNAS 183
Cdd:cd15410  93 FCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLSFCGsNVINHFFCDLPP 172

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 184 LFKLSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSlyLIMLISGLIIIVLHR 263
Cdd:cd15410 173 LLSLSCSDTYLNELLLFIFGSLNEASTLLIILTSYVFIIVTILRIRSAEGRQKAFSTCASHLT--AITIFHGTILFMYCR 250

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 18859185 264 fPAYS---DYRKIASLLFHIIPSILNPIIYGVQSSEVR 298
Cdd:cd15410 251 -PSSSyslDTDKVASVFYTVVIPMLNPLIYSLRNKDVK 287

7tmA_OR8H-like

cd15411

olfactory receptor subfamily 8H and related proteins, member of the class A family of ...

25-301

3.21e-42

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320533 [Multi-domain] Cd Length: 279 Bit Score: 147.08 E-value: 3.21e-42

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  25 PVFVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKSpsQRYISYVECVVQAFS 104
Cdd:cd15411   2 PLFVLFLVIYVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSG--RKAISFAGCFVQMYF 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 105 THTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRCRTFISNP-FCDNAS 183
Cdd:cd15411  80 FIALATTECFLLGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHfFCDTPP 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 184 LFKLSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLsLYLIMLISGLIIIVLHR 263
Cdd:cd15411 160 LLKLSCSDTHVNEMLIFILAGLTLVGSLLIILVSYTYILSTILKIRSAEGRRKAFSTCASHL-TAVTIFYGTGIFTYLRP 238

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 18859185 264 FPAYSDYR-KIASLLFHIIPSILNPIIYGVQSSEVRHVL 301
Cdd:cd15411 239 SSSYSLGQdKVASVFYTVVIPMLNPLIYSLRNKEVKNAL 277

7tmA_OR1A-like

cd15235

olfactory receptor subfamily 1A and related proteins, member of the class A family of ...

24-298

1.42e-41

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320363 [Multi-domain] Cd Length: 278 Bit Score: 145.44 E-value: 1.42e-41

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  24 YPVFVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILkSPSQRyISYVECVVQAF 103
Cdd:cd15235   2 PLLFLLFLAMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLL-SGSKT-ISYAGCLAQMY 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 104 STHTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRCRTF-ISNPFCDNA 182
Cdd:cd15235  80 FFIAFGNTDSFLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNeIPHFFCDLQ 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 183 SLFKLSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSlyLIMLISGLIIIVLH 262
Cdd:cd15235 160 PLLKLSCSDTSLNELLIFTEGAVVVLGPFLLIVLSYARILAAVLKVPSAAGRRKAFSTCGSHLT--VVALFYGTIIGVYF 237

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 18859185 263 R--FPAYSDYRKIASLLFHIIPSILNPIIYGVQSSEVR 298
Cdd:cd15235 238 QpsSSYSADKDRVATVMYTVVTPMLNPFIYSLRNKDVK 275

7tmA_OR13H-like

cd15431

olfactory receptor subfamily 13H and related proteins, member of the class A family of ...

25-290

1.83e-41

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320548 [Multi-domain] Cd Length: 269 Bit Score: 144.67 E-value: 1.83e-41

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  25 PVFVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKSpsQRYISYVECVVQAFS 104
Cdd:cd15431   2 ILFVLLLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSD--RPTISYSRCLAQMYI 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 105 THTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRCRTFISNPFCDNASL 184
Cdd:cd15431  80 SLFLGITECLLLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFLLTVIPVLTMPLHFCGPNVINHFFCEVQAL 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 185 FKLSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSLYLIMLISGLIIIVLHRF 264
Cdd:cd15431 160 LKLACSDTSLNEILMFATSIFTLLLPFSFILVSYIRIGVAVLRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMYLRPQS 239

                       250       260
                ....*....|....*....|....*.
gi 18859185 265 PAYSDYRKIASLLFHIIPSILNPIIY 290
Cdd:cd15431 240 KSSSDQDKIISVFYGVVTPMLNPLIY 265

7tmA_OR2-like

cd15237

olfactory receptor family 2 and related proteins, member of the class A family of ...

27-290

2.27e-41

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320365 [Multi-domain] Cd Length: 270 Bit Score: 144.73 E-value: 2.27e-41

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  27 FVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKSpsQRYISYVECVVQAFSTH 106
Cdd:cd15237   4 FILFLLIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSE--HKTISFVGCAAQMFFFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 107 TYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRCR-TFISNPFCDNASLF 185
Cdd:cd15237  82 ALGVTECVLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGpNHINHFFCEAPAVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 186 KLSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSLYLIMLISGLIIIVLHRFP 265
Cdd:cd15237 162 KLACADTSLNEAVIFVTSVLVLLIPFSLILASYIRILATILRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRPHST 241

                       250       260
                ....*....|....*....|....*
gi 18859185 266 AYSDYRKIASLLFHIIPSILNPIIY 290
Cdd:cd15237 242 HSPDQDKMISVFYTIVTPMLNPLIY 266

7tmA_OR5V1-like

cd15231

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...

26-301

4.70e-41

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320359 [Multi-domain] Cd Length: 277 Bit Score: 143.94 E-value: 4.70e-41

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  26 VFVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKSpsQRYISYVECVVQAFST 105
Cdd:cd15231   3 LFLIFLIIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRE--RKTISYIGCLAQLFFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 106 HTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRCRT-FISNPFCDNASL 184
Cdd:cd15231  81 VSFVGTECLLLAVMAYDRYVAICNPLHYAVIMSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFCGSnQISHFFCDIPPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 185 FKLSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSLYLIMLISGlIIIVLHRF 264
Cdd:cd15231 161 LKLSCSDTSLNEVLLLVASVFIGLTPFLFIVISYVYIISTILKIRSAEGRRKAFSTCASHLTVVTLFYGTA-IFNYNRPS 239

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 18859185 265 PAYS-DYRKIASLLFHIIPSILNPIIYGVQSSEVRHVL 301
Cdd:cd15231 240 SGYSlDKDTLISVLYSIVTPMLNPIIYSLRNKEVKGAL 277

7tmA_OR52E-like

cd15952

olfactory receptor subfamily 52E and related proteins, member of the class A family of ...

27-297

7.21e-41

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320618 Cd Length: 274 Bit Score: 143.29 E-value: 7.21e-41

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  27 FVFFLLFYVAImVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKSpsQRYISYVECVVQAFSTH 106
Cdd:cd15952   5 FPFCAVYLIAL-LGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFN--LREISFGGCLAQMFFIH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 107 TYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRCR-TFISNPFCDNASLF 185
Cdd:cd15952  82 TFTGMESAVLVAMAFDRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGhNIIPHTYCEHMGIA 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 186 KLSCEDVTINNLYGLIyTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSLYLIMLISGLIIIVLHRF- 264
Cdd:cd15952 162 KLACASIRINIIYGLF-AISVLVLDVILIALSYVLILRAVFRLPSHDARLKALSTCGSHVCVILAFYTPALFSFLTHRFg 240

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 18859185 265 ---PAYSDYrkIASLLFHIIPSILNPIIYGVQSSEV 297
Cdd:cd15952 241 hniPRYIHI--LLANLYVVLPPMLNPVIYGVRTKQI 274

7tmA_OR1_7-like

cd15918

olfactory receptor families 1, 7, and related proteins, member of the class A family of ...

27-290

8.04e-41

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320584 [Multi-domain] Cd Length: 270 Bit Score: 143.14 E-value: 8.04e-41

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  27 FVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKSpsQRYISYVECVVQAFSTH 106
Cdd:cd15918   4 FGLFLGMYLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQ--SKSISYAGCLTQMYFFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 107 TYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRC-RTFISNPFCDNASLF 185
Cdd:cd15918  82 LFGDLDNFLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCaSNEIPHFFCDLNPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 186 KLSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSlyLIMLISGLIIIVLHRFP 265
Cdd:cd15918 162 KLSCSDTHLNELVILVLGGLVGLVPFLCILVSYVRIVSAVLRIPSAGGKWKAFSTCGSHLS--VVSLFYGTVIGVYLSPP 239

                       250       260
                ....*....|....*....|....*..
gi 18859185 266 A--YSDYRKIASLLFHIIPSILNPIIY 290
Cdd:cd15918 240 SshSASKDSVAAVMYTVVTPMLNPFIY 266

7tmA_OR11A-like

cd15911

olfactory receptor subfamily 11A and related proteins, member of the class A family of ...

25-290

1.49e-40

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320577 Cd Length: 270 Bit Score: 142.62 E-value: 1.49e-40

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  25 PVFVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKSPsqRYISYVECVVQAFS 104
Cdd:cd15911   2 LLFLLFLVIYIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGD--RTISVSGCIVQFYF 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 105 THTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRCR-TFISNPFCDNAS 183
Cdd:cd15911  80 FGSLAATECYLLAVMSYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGpNEIDHFFCDFAP 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 184 LFKLSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHL---SLYLIMLIsglIIIV 260
Cdd:cd15911 160 LLKLSCSDTSLVELVTFILSSIVTLPPFLLTLTSYICIISTILRIPSTTGRQKAFSTCSSHLivvTIFYGTLI---IVYV 236

                       250       260       270
                ....*....|....*....|....*....|
gi 18859185 261 LHRFPAYSDYRKIASLLFHIIPSILNPIIY 290
Cdd:cd15911 237 VPSTNTSRDLNKVFSLFYTVLTPLVNPLIY 266

7tmA_OR51-like

cd15222

olfactory receptor family 51 and related proteins, member of the class A family of ...

26-297

3.04e-40

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320350 Cd Length: 275 Bit Score: 141.87 E-value: 3.04e-40

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  26 VFVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLmDILKSPSqRYISYVECVVQAFST 105
Cdd:cd15222   3 ISIPFCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVL-GIFWFNA-REISFDACLAQMFFI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 106 HTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRCRTFI-SNPFCDNASL 184
Cdd:cd15222  81 HTFSFMESSVLLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVlSHSYCLHQDV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 185 FKLSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSLYLIMLISGLIIIVLHRF 264
Cdd:cd15222 161 MKLACSDTRVNSIYGLFVVLSTMGLDSLLILLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYVPMIGLSMVHRF 240

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 18859185 265 paysdyRKIASLLFHII--------PSILNPIIYGVQSSEV 297
Cdd:cd15222 241 ------GKHASPLVHVLmanvyllvPPVLNPIIYSVKTKQI 275

7tmA_OR6B-like

cd15224

olfactory receptor subfamily 6B and related proteins, member of the class A family of ...

27-290

3.68e-40

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320352 Cd Length: 270 Bit Score: 141.65 E-value: 3.68e-40

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  27 FVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKSpsQRYISYVECVVQAFSTH 106
Cdd:cd15224   4 FLLFLIAYVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQ--NKSISFVGCMTQLYFFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 107 TYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRCRTFISNP-FCDNASLF 185
Cdd:cd15224  82 SLACTECVLLAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHfFCDISPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 186 KLSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSLYLIMLISGLIIIVLHRFP 265
Cdd:cd15224 162 NLSCTDMSLAELVDFILALIILLVPLLVTVASYICIISTVLRIPSATGRQKAFSTCASHLTVVIIFYSATLFMYARPKAI 241

                       250       260
                ....*....|....*....|....*
gi 18859185 266 AYSDYRKIASLLFHIIPSILNPIIY 290
Cdd:cd15224 242 SSFDSNKLVSVLYTVVTPLLNPIIY 266

7tmA_OR5AP2-like

cd15943

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...

13-305

4.24e-40

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320609 [Multi-domain] Cd Length: 295 Bit Score: 142.12 E-value: 4.24e-40

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  13 LEGLRVSEEATYPVFVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKSpsQRY 92
Cdd:cd15943   4 LLGLTDNPELQVILFAVFLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAE--NKT 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  93 ISYVECVVQAFSTHTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRCRT 172
Cdd:cd15943  82 ISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFCGS 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 173 -FISNPFCDNASLFKLSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLsLYLIM 251
Cdd:cd15943 162 nVINHFFCDVPPLLKLSCSDTHVNEIVLFAFAIFLGIFTSLEILVSYVYILSAILRIHSSEGRRKAFSTCASHL-MAVTI 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 18859185 252 LISGLIIIVLHRFPAYS-DYRKIASLLFHIIPSILNPIIYGVQSSEVRHVLIQVL 305
Cdd:cd15943 241 FYGTTLFMYLRPSSSYSlDQDKVVSVFYTVVIPMLNPLIYSLRNKEVKDALRRIL 295

7tmA_OR12D-like

cd15915

olfactory receptor subfamily 12D and related proteins, member of the class A family of ...

26-290

4.36e-40

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320581 [Multi-domain] Cd Length: 271 Bit Score: 141.29 E-value: 4.36e-40

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  26 VFVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKSpsQRYISYVECVVQAFST 105
Cdd:cd15915   3 LFVLFLLLYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSE--HKTISFQGCISQLHFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 106 HTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRCRT-FISNPFCDNASL 184
Cdd:cd15915  81 HFLGSSEAMLLAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPnKINHFFCDIKPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 185 FKLSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITA-VCLVTKSKMLNSRALKTCSTHLSLYLIMLISGLIIIVLHR 263
Cdd:cd15915 161 LKLACGDTSLNLWLLNIVTGSIALGTFILTLLSYIYIISfLLLKVRSKEGRHKAFSTCASHLTVVLLLYGPALFTYIRPS 240

                       250       260
                ....*....|....*....|....*..
gi 18859185 264 FPAYSDYRKIASLLFHIIPSILNPIIY 290
Cdd:cd15915 241 SGDSLEQDRIVALLYTVVTPVLNPLIY 267

7tmA_OR9K2-like

cd15419

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...

27-301

4.89e-40

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320541 Cd Length: 279 Bit Score: 141.29 E-value: 4.89e-40

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  27 FVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKSpsQRYISYVECVVQAFSTH 106
Cdd:cd15419   4 FLLFLVIYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSE--SKTISYNGCAAQFFFFS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 107 TYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRCR-TFISNPFCDNASLF 185
Cdd:cd15419  82 LFGTTEGFLLAAMAYDRFIAICNPLLYPVIMSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGsNEIDHFFCDVPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 186 KLSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSLYLIMLISGLIIIVLHRFP 265
Cdd:cd15419 162 KLSCSDTFINELVMFVLCGLIIVSTILVILVSYAYILSTILRIPSAEGRKKAFSTCASHLTAVSLFYGTVFFMYAQPGAV 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 18859185 266 AYSDYRKIASLLFHIIPSILNPIIYGVQSSEVRHVL 301
Cdd:cd15419 242 SSPEQSKVVSVFYTLVIPMLNPLIYSLRNKDVKEAL 277

7tmA_OR5A1-like

cd15417

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...

27-301

5.06e-40

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320539 Cd Length: 279 Bit Score: 141.24 E-value: 5.06e-40

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  27 FVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKSpsQRYISYVECVVQAFSTH 106
Cdd:cd15417   4 FVLFLGIYLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFRE--QKTISFVGCATQYFVFS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 107 TYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRC-RTFISNPFCDNASLF 185
Cdd:cd15417  82 GMGLTECFLLAAMAYDRYVAICNPLLYSVIMSPRLCVQLVAGAYLGGFLNSLIQTVSMFQLSFCgPNVIDHFFCDIPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 186 KLSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSLYLIMLISGLIIIVLHRFP 265
Cdd:cd15417 162 SLSCSDTFISQVVLFLVAVLFGVFSVLVVLISYGYIISTILKIRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYLRPSSS 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 18859185 266 AYSDYRKIASLLFHIIPSILNPIIYGVQSSEVRHVL 301
Cdd:cd15417 242 HSQDQDKVASVFYTVVIPMLNPLIYSLRNKEIKDAL 277

7tmA_OR5P-like

cd15416

olfactory receptor subfamily 5P and related proteins, member of the class A family of ...

25-301

7.56e-40

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320538 [Multi-domain] Cd Length: 279 Bit Score: 140.96 E-value: 7.56e-40

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  25 PVFVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKSpsQRYISYVECVVQAFS 104
Cdd:cd15416   2 ILFVLFLVIYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVE--KTTISYPGCAAQLCS 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 105 THTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRCRTFISNPF-CDNAS 183
Cdd:cd15416  80 AATFGTVECFLLAAMAYDRYVAICNPLLYSTIMSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFfCDFPP 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 184 LFKLSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSLYLIMLISGLIIIVLHR 263
Cdd:cd15416 160 LLKLSCSDIRLAKILPSISSGIIILVTVLTIIISYLYILIAILRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPN 239

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 18859185 264 FPAYSDYRKIASLLFHIIPSILNPIIYGVQSSEVRHVL 301
Cdd:cd15416 240 SSYSMDQNKVVSVFYMVVIPMLNPLIYSLRNKEVKGAL 277

7tmA_OR8D-like

cd15406

olfactory receptor subfamily 8D and related proteins, member of the class A family of ...

15-305

1.22e-39

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320528 [Multi-domain] Cd Length: 290 Bit Score: 140.58 E-value: 1.22e-39

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  15 GLRVSEEATYPVFVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILksPSQRYIS 94
Cdd:cd15406   1 GLTDQPELQLPLFLLFLGIYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFV--SEKNIIS 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  95 YVECVVQAFSTHTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRCRT-F 173
Cdd:cd15406  79 YPECMTQLFFFCVFAIAECYMLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDnV 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 174 ISNPFCDNASLFKLSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSLYLIMLI 253
Cdd:cd15406 159 INHYFCDILPLLKLSCSSTYINELLLFIVGGFNVLATTLAILISYAFILSSILRIRSAEGRSKAFSTCSSHLAAVGVFYG 238

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 18859185 254 SgliIIVLHRFPAYS---DYRKIASLLFHIIPSILNPIIYGVQSSEVRHVLIQVL 305
Cdd:cd15406 239 S---IIFMYLKPSSSssmTQEKVSSVFYTTVIPMLNPLIYSLRNKDVKNALKKVL 290

7tmA_OR5J-like

cd15415

olfactory receptor subfamily 5J and related proteins, member of the class A family of ...

25-301

2.04e-39

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320537 [Multi-domain] Cd Length: 279 Bit Score: 139.86 E-value: 2.04e-39

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  25 PVFVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKspSQRYISYVECVVQAFS 104
Cdd:cd15415   2 PLFMLFLLIYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLV--EKKTISYSACIAQHFF 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 105 THTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRCR-TFISNPFCDNAS 183
Cdd:cd15415  80 FAVFVTTEGFLLAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGpNVINHYFCDIPP 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 184 LFKLSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSLyLIMLISGLIIIVLHR 263
Cdd:cd15415 160 LLKLSCSDTHINELLLLTFSGVIAMSTLLTIIISYIFILFAILRIRSAEGRRKAFSTCASHLTA-VTLFYGSVSFSYIQP 238

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 18859185 264 FPAYS-DYRKIASLLFHIIPSILNPIIYGVQSSEVRHVL 301
Cdd:cd15415 239 SSQYSlEQEKVSAVFYTLVIPMLNPLIYSLRNKDVKDAL 277

7tmA_OR2W-like

cd15434

olfactory receptor subfamily 2W and related proteins, member of the class A family of ...

26-298

2.33e-39

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320551 [Multi-domain] Cd Length: 277 Bit Score: 139.44 E-value: 2.33e-39

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  26 VFVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDIlkSPSQRYISYVECVVQAFST 105
Cdd:cd15434   3 LSVVVLIFYLLTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVNL--WGPDKTISYVGCAIQLFIA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 106 HTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRC-RTFISNPFCDNASL 184
Cdd:cd15434  81 LGLGGTECVLLAVMAYDRYAAVCQPLHYTVVMHPRLCWKLVAMSWLIGFGNSLVLSPLTLSLPRCgHHRVDHFFCEMPAL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 185 FKLSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSLyLIMLISGLIIIVLHRF 264
Cdd:cd15434 161 IKLACVDTTAYEATIFALGVFILLFPLSLILVSYGYIARAVLKIKSAAGRKKAFGTCGSHLTV-VSLFYGTIIYMYLQPK 239

                       250       260       270
                ....*....|....*....|....*....|....*
gi 18859185 265 PAYS-DYRKIASLLFHIIPSILNPIIYGVQSSEVR 298
Cdd:cd15434 240 NSVSqDQGKFLTLFYTIVTPSLNPLIYTLRNKDVK 274

7tmA_OR4-like

cd15226

olfactory receptor family 4 and related proteins, member of the class A family of ...

27-290

2.67e-39

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320354 [Multi-domain] Cd Length: 267 Bit Score: 139.26 E-value: 2.67e-39

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  27 FVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKSpsQRYISYVECVVQAFSTH 106
Cdd:cd15226   4 FVFFSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLRE--HKTISFGGCMAQIFFLH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 107 TYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRC-RTFISNPFCDNASLF 185
Cdd:cd15226  82 FFGGSEMVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCgPNVVDSFFCDLPLVI 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 186 KLSCED-------VTINNlyGLIYTVLLFGssmgsIAVTYIKITaVCLVTKSKMLNSRALKTCSTHLSLyLIMLISGLII 258
Cdd:cd15226 162 KLACTDtyvlelmVVANS--GLISLVCFLL-----LLISYIVIL-VTVRKHSSGGSSKALSTCSAHITV-VVLFFGPCIF 232

                       250       260       270
                ....*....|....*....|....*....|..
gi 18859185 259 IVLHRFPAYSdYRKIASLLFHIIPSILNPIIY 290
Cdd:cd15226 233 IYVWPFSTFP-VDKFLAVFYTVITPLLNPIIY 263

7tmA_OR52K-like

cd15948

olfactory receptor subfamily 52K and related proteins, member of the class A family of ...

30-298

4.16e-39

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320614 [Multi-domain] Cd Length: 277 Bit Score: 138.88 E-value: 4.16e-39

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  30 FLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMdiLKSPSQRYISYVECVVQAFSTHTYG 109
Cdd:cd15948   8 FCSAFTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILS--IFWFNSREINFNACLVQMFFLHSFS 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 110 TTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRCRT-FISNPFCDNASLFKLS 188
Cdd:cd15948  86 IMESAVLLAMAFDRYVAICNPLRYATILTNSVITKIGLAALARAVTLMTPLPFLLRRLPYCRShVIAHCYCEHMAVVKLA 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 189 CEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSLYLIMLISGLIIIVLHRFP--A 266
Cdd:cd15948 166 CGDTRFNNIYGIAVALFIVGLDLMFIILSYVFILRAVLSLASKEEQLKAFGTCGSHICAILVFYTPVVLSSTMHRFArhV 245

                       250       260       270
                ....*....|....*....|....*....|..
gi 18859185 267 YSDYRKIASLLFHIIPSILNPIIYGVQSSEVR 298
Cdd:cd15948 246 APHVHILLANFYLLFPPMMNPIVYGVKTKQIR 277

7tmA_OR7-like

cd15234

olfactory receptor family 7 and related proteins, member of the class A family of ...

25-301

4.32e-39

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320362 [Multi-domain] Cd Length: 277 Bit Score: 138.86 E-value: 4.32e-39

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  25 PVFVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKSpsQRYISYVECVVQAFS 104
Cdd:cd15234   2 LLFGLFLSMYLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQ--SKSISYTGCLTQMCF 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 105 THTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRCRTF-ISNPFCDNAS 183
Cdd:cd15234  80 FLLFGGLDNFLLAVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTDVeIPHFFCELAQ 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 184 LFKLSCEDVTINNLygLIY--TVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSLYLIMLISGLIIIVL 261
Cdd:cd15234 160 VLKLACSDTLINNI--LIYlaTVIFGGIPLSGIIFSYYKIVSSILRIPSSGGKYKAFSTCGSHLSVVSLFYGTGLGVYIS 237

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 18859185 262 HRFPAYSDYRKIASLLFHIIPSILNPIIYGVQSSEVRHVL 301
Cdd:cd15234 238 SAVTHSSRKTAVASVMYTVVTPMLNPFIYSLRNKDMKGAL 277

7tmA_OR52M-like

cd15949

olfactory receptor subfamily 52M and related proteins, member of the class A family of ...

30-298

1.40e-38

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320615 Cd Length: 292 Bit Score: 137.99 E-value: 1.40e-38

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  30 FLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKSpsQRYISYVECVVQAFSTHTYG 109
Cdd:cd15949  23 FCSMYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFS--SNEIPLHACLLQMFLIHSFS 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 110 TTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRCRT-FISNPFCDNASLFKLS 188
Cdd:cd15949 101 AIESGIFLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLYISPLPLLVRRLPWYRTnIIAHSYCEHMAVVGLA 180

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 189 CEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSLYLIMLISGLIIIVLHRFpAYS 268
Cdd:cd15949 181 CGDVSINNHYGLTIGFLVLIMDSLFIVLSYIMILRVVQRLATSEARLKTFGTCVSHVCAILAFYVPIAVSSLIHRF-GQN 259

                       250       260       270
                ....*....|....*....|....*....|...
gi 18859185 269 DYRKIASLL---FHIIPSILNPIIYGVQSSEVR 298
Cdd:cd15949 260 VPPPTHILLanfYLLIPPMLNPIVYGVRTKQIQ 292

7tmA_OR2B2-like

cd15432

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...

25-301

2.14e-38

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320549 [Multi-domain] Cd Length: 277 Bit Score: 137.22 E-value: 2.14e-38

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  25 PVFVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDIlkSPSQRYISYVECVVQAFS 104
Cdd:cd15432   2 VLFVVFLIFYILTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNL--RSPQKTISYGGCVAQLFI 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 105 THTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRC-RTFISNPFCDNAS 183
Cdd:cd15432  80 FLGLGSTECVLLAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCgRRRVDHFFCEVPA 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 184 LFKLSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSLYLIMLISGLIIIVLHR 263
Cdd:cd15432 160 LLKLSCVDTTANEAELFVISVLLLLIPLGLILISYIFIVRAVLRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYLQPP 239

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 18859185 264 FPAYSDYRKIASLLFHIIPSILNPIIYGVQSSEVRHVL 301
Cdd:cd15432 240 SNSSHDRGKMVALFYGIITPMLNPLIYTLRNKDVKEAL 277

7tmA_OR2B-like

cd15947

olfactory receptor subfamily 2B and related proteins, member of the class A family of ...

25-290

2.74e-38

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320613 [Multi-domain] Cd Length: 270 Bit Score: 136.60 E-value: 2.74e-38

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  25 PVFVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDiLKSPsQRYISYVECVVQAFS 104
Cdd:cd15947   2 PLFVVVLIFYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVN-LWGP-DKTISYGGCVTQLYI 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 105 THTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRC-RTFISNPFCDNAS 183
Cdd:cd15947  80 FLWLGSTECVLLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCgHHTLDHFFCEVPA 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 184 LFKLSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSLYLIMLISGLIIIVLHR 263
Cdd:cd15947 160 LIKLACVDTTFNELELFVASVFFLLVPLSLILVSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPP 239

                       250       260
                ....*....|....*....|....*..
gi 18859185 264 FPAYSDYRKIASLLFHIIPSILNPIIY 290
Cdd:cd15947 240 SSYSQDQGKFISLFYTVVTPTLNPLIY 266

7tmA_OR13-like

cd15430

olfactory receptor family 13 and related proteins, member of the class A family of ...

27-290

4.38e-38

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320547 [Multi-domain] Cd Length: 270 Bit Score: 135.96 E-value: 4.38e-38

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  27 FVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKSpsQRYISYVECVVQAFSTH 106
Cdd:cd15430   4 FVLCLIMYLVILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSE--RKTISFSGCAVQMYLSL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 107 TYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRCRTFISNPF-CDNASLF 185
Cdd:cd15430  82 AMGSTECVLLAVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFtCEILAVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 186 KLSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSLYLIMLISGLIIIVLHRFP 265
Cdd:cd15430 162 KLACVDISLNEIIMLVGNIIFLVIPLLLICISYIFILSTILRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPKSK 241

                       250       260
                ....*....|....*....|....*
gi 18859185 266 AYSDYRKIASLLFHIIPSILNPIIY 290
Cdd:cd15430 242 NAQISDKLITLFYGVVTPMLNPIIY 266

7tmA_OR4A-like

cd15939

olfactory receptor 4A and related proteins, member of the class A family of ...

26-290

2.08e-37

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320605 [Multi-domain] Cd Length: 267 Bit Score: 134.26 E-value: 2.08e-37

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  26 VFVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKSpsQRYISYVECVVQAFST 105
Cdd:cd15939   3 CFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSE--RKTISFNGCMTQLFAE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 106 HTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRC-RTFISNPFCDNASL 184
Cdd:cd15939  81 HFFGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCgPNVIDHFFCDLFPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 185 FKLSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITaVCLVTKSKMLNSRALKTCSTHLSlyLIMLISGLIIIVLHRF 264
Cdd:cd15939 161 LKLACTDTYVIGLLVVANSGLICLLSFLILLISYIVIL-YSLRTHSSEGRRKALSTCGSHIT--VVVLFFVPCIFIYMRP 237

                       250       260
                ....*....|....*....|....*.
gi 18859185 265 PAYSDYRKIASLLFHIIPSILNPIIY 290
Cdd:cd15939 238 VTTFPIDKVVAVFYTIITPMLNPLIY 263

7tmA_OR5C1-like

cd15945

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...

25-303

5.38e-37

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320611 Cd Length: 292 Bit Score: 133.72 E-value: 5.38e-37

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  25 PVFVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKspSQRYISYVECVVQAFS 104
Cdd:cd15945  15 TLFLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLA--KRKSIPFYGCALQMFF 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 105 THTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRCRTFISNP-FCDNAS 183
Cdd:cd15945  93 FAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGSNTINHfFCDIPP 172

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 184 LFKLSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSLYLIMLISgLIIIVLHR 263
Cdd:cd15945 173 LLALSCSDTQINELLLFALCGFIQTSTFLAIIISYCYIIITVLKIRSAEGRFKAFSTCASHLTAVGLFYGT-LLFMYLRP 251

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 18859185 264 FPAYS-DYRKIASLLFHIIPSILNPIIYGVQSSEVRHVLIQ 303
Cdd:cd15945 252 SSSYSlDTDKMTSVFYTLVIPMLNPLIYSLRNKDVKEALKK 292

7tmA_OR6N-like

cd15914

olfactory receptor OR6N and related proteins, member of the class A family of ...

27-291

1.26e-36

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320580 [Multi-domain] Cd Length: 270 Bit Score: 132.11 E-value: 1.26e-36

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  27 FVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKSpsQRYISYVECVVQAFSTH 106
Cdd:cd15914   4 FILLLLIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSE--EKTISFNGCLLQMYFFH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 107 TYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRC-RTFISNPFCDNASLF 185
Cdd:cd15914  82 SLGITECYLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCgPNQIQHIFCDFPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 186 KLSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSLYLIMLisGLIIIVLHRFP 265
Cdd:cd15914 162 SLACTDTSLNVLVDFVIHAVIILLTFLLILLSYVKIISVVLKIPSAEGRQKAFSTCAAHLTVVLLFF--GSVSFMYLRLS 239

                       250       260
                ....*....|....*....|....*...
gi 18859185 266 A-YS-DYRKIASLLFHIIPSILNPIIYG 291
Cdd:cd15914 240 KsYSlDYDRAIAVVYAVLTPFFNPIIYS 267

7tmA_OR52N-like

cd15954

olfactory receptor subfamily 52N and related proteins, member of the class A family of ...

30-297

4.15e-36

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320620 Cd Length: 276 Bit Score: 131.10 E-value: 4.15e-36

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  30 FLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKSPSQryISYVECVVQAFSTHTYG 109
Cdd:cd15954   7 FCFMYIIAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKE--ISFNACLVQMFFVHTFT 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 110 TTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRCRT-FISNPFCDNASLFKLS 188
Cdd:cd15954  85 GMESGVLMLMALDRYVAICYPLRYATILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGnFIPHTYCDHMSVVKLA 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 189 CEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSLYLIMLISGLIIIVLHRFPAY- 267
Cdd:cd15954 165 CANIRVDAIYGLMVALLIGGFDILCISVSYAMILRAVVSLSSKEARSKAFSTCTAHICAIVITYTPAFFTFFAHRFGGHh 244

                       250       260       270
                ....*....|....*....|....*....|..
gi 18859185 268 --SDYRKIASLLFHIIPSILNPIIYGVQSSEV 297
Cdd:cd15954 245 itPHIHIIMANLYLLLPPMMNPIVYGVKTKQI 276

7tmA_OR10G-like

cd15916

olfactory receptor subfamily 10G and related proteins, member of the class A family of ...

25-301

9.87e-36

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320582 [Multi-domain] Cd Length: 276 Bit Score: 129.88 E-value: 9.87e-36

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  25 PVFVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILkSPSQRYISYVECVVQAFS 104
Cdd:cd15916   2 LLFLIFLIIYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFL-EPGGKVISFGGCVAQLYF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 105 THTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRCRTF-ISNPFCDNAS 183
Cdd:cd15916  81 FHFLGSTECFLYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNrIDYFFCDIPP 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 184 LFKLSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSLYLIMLISGLIIIVLHR 263
Cdd:cd15916 161 LLKLACADTTINELVIFASIGVVALGCFILILLSYGNIVRAILRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLRPG 240

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 18859185 264 FPAYSDyrKIASLLFHIIPSILNPIIYGVQSSEVRHVL 301
Cdd:cd15916 241 SKEALD--GVIAVFYTVVTPLLNPLIYTLRNKEVKTAL 276

7tmA_OR2F-like

cd15429

olfactory receptor subfamily 2F and related proteins, member of the class A family of ...

27-301

1.45e-35

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320546 [Multi-domain] Cd Length: 277 Bit Score: 129.44 E-value: 1.45e-35

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  27 FVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKSpsQRYISYVECVVQAFSTH 106
Cdd:cd15429   4 FVLFLVMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAE--HKTISFASCVAQLFISL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 107 TYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRCRTFISNPF-CDNASLF 185
Cdd:cd15429  82 ALGGTEFILLAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFsCELLAVV 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 186 KLSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSlyLIMLISGLIIIVLHRFP 265
Cdd:cd15429 162 RLACVDTSLNEVAILVSSVVVLLTPCFLVLLSYIHIISAILRIRSSEGRHKAFSTCASHLT--VVSLCYGTAIFTYMRPR 239

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 18859185 266 AYS--DYRKIASLLFHIIPSILNPIIYGVQSSEVRHVL 301
Cdd:cd15429 240 SGSsaLQEKMISLFYAVVTPMLNPLIYSLRNKEVKGAL 277

7tmA_OR4D-like

cd15936

olfactory receptor 4D and related proteins, member of the class A family of ...

24-290

2.29e-35

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320602 [Multi-domain] Cd Length: 267 Bit Score: 128.99 E-value: 2.29e-35

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  24 YPVFVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKSPsqRYISYVECVVQAF 103
Cdd:cd15936   1 FFLFLVFLLVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQT--KTISFNGCMAQMF 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 104 STHTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRCRTFI-SNPFCDNA 182
Cdd:cd15936  79 FFHFTGGAEVFLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNVlDNFYCDVP 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 183 SLFKLSCEDVTINNLY-----GLIyTVLLFGSSMGSIAVTYIKITavclvTKSKMLNSRALKTCSTHLSLYLIMLISGlI 257
Cdd:cd15936 159 QVIKLACTDTFLLELLmvsnsGLV-TLLIFFILLISYTVILVKIR-----THVTEGKRKALSTCASQITVVTLIFVPC-I 231

                       250       260       270
                ....*....|....*....|....*....|...
gi 18859185 258 IIVLHRFPAYSdYRKIASLLFHIIPSILNPIIY 290
Cdd:cd15936 232 YIYARPFQTFP-MDKAVSVLYTVITPMLNPMIY 263

7tmA_OR5AR1-like

cd15944

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...

27-305

6.37e-35

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320610 [Multi-domain] Cd Length: 294 Bit Score: 128.36 E-value: 6.37e-35

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  27 FVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKSpsQRYISYVECVVQAFSTH 106
Cdd:cd15944  17 FVVFLIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTK--HKVISFSGCATQFAFFV 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 107 TYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRCRTFISNP-FCDNASLF 185
Cdd:cd15944  95 GFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGSNIINHfFCDVPPLL 174

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 186 KLSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSlyLIMLISGLIIIVLHRFP 265
Cdd:cd15944 175 ALSCSDTHINEILLYVFCGFVEMSSLSIILISYLFILVAILRMRSAEGRRKAFSTCASHFT--GVTLFYGTVIFMYLRPT 252

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 18859185 266 AYS--DYRKIASLLFHIIPSILNPIIYGVQSSEVRHVLIQVL 305
Cdd:cd15944 253 SVYslDQDKWASVFYTVVIPMLNPLIYSLRNKDVKEAFKKLI 294

7tmA_OR10D-like

cd15228

olfactory receptor subfamily 10D and related proteins, member of the class A family of ...

27-301

8.51e-35

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320356 [Multi-domain] Cd Length: 275 Bit Score: 127.55 E-value: 8.51e-35

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  27 FVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDIlkSPSQRYISYVECVVQAFSTH 106
Cdd:cd15228   4 FVLFLAFYLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYL--WGQSRVISLGGCMSQVFFYH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 107 TYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRC-RTFISNPFCDNASLF 185
Cdd:cd15228  82 FLGSTECLLYTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCgSNVVDYFFCDIFPVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 186 KLSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSlyLIMLISGLIIIVLHRFP 265
Cdd:cd15228 162 KLACADTSIAETVSFTNVGLVPLTCFLLILASYVRIVISILKMRSAEGRRKAFSTCSSHLT--VVTLFFGPCALIYTQPT 239

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 18859185 266 AYSDYRKIASLLFHIIPSILNPIIYGVQSSEVRHVL 301
Cdd:cd15228 240 PSPVLVTPVQIFNNVVTPMLNPLIYTLRNKEVKAAL 275

7tmA_OR52W-like

cd15956

olfactory receptor subfamily 52W and related proteins, member of the class A family of ...

30-297

8.58e-35

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320622 [Multi-domain] Cd Length: 275 Bit Score: 127.67 E-value: 8.58e-35

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  30 FLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKSPsqRYISYVECVVQAFSTHTYG 109
Cdd:cd15956   7 FCFIYVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGA--TAISSYVCLSQMFLVHAFS 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 110 TTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALawgIALLFISILI---GLTLRLSRCRT-FISNPFCDNASLF 185
Cdd:cd15956  85 AMESGVLVAMALDRFVAICNPLHYATILTLEVVAKAGLL---LALRGVAIVIpfpLLVCRLSFCAShTIAHTYCEHMAVV 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 186 KLSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSLYLIMLISGLIIIVLHRFP 265
Cdd:cd15956 162 KLACGATTVDSLYGLALALFIGGGDVLFIAYSYGLIVKTVLRLPSPEARGKAFSTCSAHICVILFFYIPGLLSVLMHRFG 241

                       250       260       270
                ....*....|....*....|....*....|....
gi 18859185 266 AY--SDYRKIASLLFHIIPSILNPIIYGVQSSEV 297
Cdd:cd15956 242 HSvpSAAHVLLSNLYLLLPPALNPIVYGIRTKQI 275

7tmA_OR4E-like

cd15940

olfactory receptor 4E and related proteins, member of the class A family of ...

24-290

8.82e-35

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320606 [Multi-domain] Cd Length: 267 Bit Score: 127.17 E-value: 8.82e-35

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  24 YPVFVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKSpsQRYISYVECVVQAF 103
Cdd:cd15940   1 LAFFMLFLVLYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSE--EKTISFNGCVTQLF 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 104 STHTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRC-RTFISNPFCDNA 182
Cdd:cd15940  79 FLHLFACTEIFLLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCgPNEIDSFFCDVP 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 183 SLFKLSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKItAVCLVTKSKMLNSRALKTCSTHLSlyLIMLISGLIIIVLH 262
Cdd:cd15940 159 PVIKLACTDTYLIDILIVSNSGLISLVCFVALLGSYIVI-LVSLRKRSTEGRRKALSTCASHLT--VVTLFFGPCIFIYT 235

                       250       260
                ....*....|....*....|....*...
gi 18859185 263 RFPAYSDYRKIASLLFHIIPSILNPIIY 290
Cdd:cd15940 236 RPSTSFSEDKVVSVFYTVVTPLLNPIIY 263

7tmA_OR5B-like

cd15407

olfactory receptor subfamily 5B and related proteins, member of the class A family of ...

25-303

9.32e-35

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320529 Cd Length: 279 Bit Score: 127.54 E-value: 9.32e-35

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  25 PVFVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILksPSQRYISYVECVVQAFS 104
Cdd:cd15407   2 PLFIIFTLIYLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLL--TGDKVISYNACAAQMFF 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 105 THTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRCRT-FISNPFCDNAS 183
Cdd:cd15407  80 FVVFATVENFLLASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSnVINHFFCDIPP 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 184 LFKLSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSLYLIMLISGLIIIVLHR 263
Cdd:cd15407 160 VLALSCSDIHISEIVLFFLASFNVFFALLVILISYLFIFITILRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPS 239

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 18859185 264 FPAYSDYRKIASLLFHIIPSILNPIIYGVQSSEVRHVLIQ 303
Cdd:cd15407 240 SSHSMDTDKMASVFYTMVIPMLNPLVYSLRNKEVKSAFKK 279

7tmA_OR1330-like

cd15946

olfactory receptor 1330 and related proteins, member of the class A family of ...

26-290

9.52e-35

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320612 Cd Length: 270 Bit Score: 127.21 E-value: 9.52e-35

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  26 VFVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKSpsQRYISYVECVVQAFST 105
Cdd:cd15946   3 LFAVFLLIYLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSH--KKTISFTGCVAQMYIF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 106 HTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRC-RTFISNPFCDNASL 184
Cdd:cd15946  81 LALGITECTLFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCgPNEINHYFCEVPAV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 185 FKLSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSLYLIMLISGLIIIVLHRF 264
Cdd:cd15946 161 LKLACADTSLNEMVDFVLGVIVLVVPLSLILASYVNIFKAILKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPGS 240

                       250       260
                ....*....|....*....|....*.
gi 18859185 265 PAYSDYRKIASLLFHIIPSILNPIIY 290
Cdd:cd15946 241 NYSPERDKKISLFYNVFTALLNPVIY 266

7tmA_OR10S1-like

cd15941

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...

27-301

1.59e-34

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320607 [Multi-domain] Cd Length: 277 Bit Score: 126.89 E-value: 1.59e-34

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  27 FVFFLLFYVAIMVLNIGIFIVITTHRSLHE-PMYMLFCNLPINDILGNSIMVPRLLMDILkSPSQRYISYVECVVQAFST 105
Cdd:cd15941   4 FLLFLLIYLLTVLGNLLILLTIGSDPHLHGlPMYHFLGHLSFLDACLSSVTVPKVLAGLL-TLSGRTISFEGCVVQLYAF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 106 HTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRC-RTFISNPFCDNASL 184
Cdd:cd15941  83 HFLASTECFLYTVMAYDRYLAICHPLHYPTAMNRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCgPCQIAYFFCDIPPV 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 185 FKLSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSLYLIMLISGLIIIVLHRF 264
Cdd:cd15941 163 LKLACADTTINELVILANIGIVAAGCFLLIVISYIYIVAAVLRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQPSS 242

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 18859185 265 PAYSDyrKIASLLFHIIPSILNPIIYGVQSSEVRHVL 301
Cdd:cd15941 243 SQAGA--GAPAVFYTIVTPMLNPFIYTLRNKEVKRAL 277

7tmA_OR2D-like

cd15428

olfactory receptor subfamily 2D and related proteins, member of the class A family of ...

26-301

3.24e-34

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320545 [Multi-domain] Cd Length: 277 Bit Score: 126.06 E-value: 3.24e-34

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  26 VFVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKSpsQRYISYVECVVQAFST 105
Cdd:cd15428   3 LFILFLIIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSE--RKIISFIRCAAQLYFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 106 HTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRCR-TFISNPFCDNASL 184
Cdd:cd15428  81 LSFGITECALLSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGhNKINHFLCEMPAL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 185 FKLSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSLYLIMLISGLIIIVLHRF 264
Cdd:cd15428 161 LKLASTDTHQAEMAMFIMCVFTLVLPVLLILASYTRIIYTVFGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPKS 240

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 18859185 265 PAYSDYRKIASLLFHIIPSILNPIIYGVQSSEVRHVL 301
Cdd:cd15428 241 STSKEYDKMISVFYIIVTPMLNPLIYSLRNKEVKHAL 277

7tmA_OR1E-like

cd15236

olfactory receptor subfamily 1E and related proteins, member of the class A family of ...

27-301

4.79e-34

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320364 [Multi-domain] Cd Length: 277 Bit Score: 125.65 E-value: 4.79e-34

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  27 FVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDIlkSPSQRYISYVECVVQAFSTH 106
Cdd:cd15236   4 FALFLAMYLTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNM--QTQDQSIPYAGCISQMYFFI 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 107 TYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRCR-TFISNPFCDNASLF 185
Cdd:cd15236  82 FFGCLDSFLLAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCAdNVIPHFFCDLVALL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 186 KLSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSLYLIMLISGLIIIVLHRFP 265
Cdd:cd15236 162 KLSCSSTSLNELVIFTEGGLLFVLPLLLILGSYIRIAATILKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSSN 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 18859185 266 AYSDYRKIASLLFHIIPSILNPIIYGVQSSEVRHVL 301
Cdd:cd15236 242 NSSDKDIVASVMYTVVTPMLNPFIYSLRNRDIKGAL 277

7tmA_OR10G6-like

cd15942

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...

25-301

6.58e-34

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320608 Cd Length: 275 Bit Score: 125.24 E-value: 6.58e-34

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  25 PVFVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILksPSQRYISYVECVVQAFS 104
Cdd:cd15942   2 PLFLFFLVVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFL--SGGRIISFGGCVTQLFF 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 105 THTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRC-RTFISNPFCDNAS 183
Cdd:cd15942  80 FHFLGCAECFLYTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGqKNEVDYIFCDIPA 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 184 LFKLSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSLYLIMLISGLIIIVlhR 263
Cdd:cd15942 160 MLKLACADTAFNELVTFIDIGLVAMTCFLLILMSYVYIVSAILKIPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYL--R 237

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 18859185 264 FPAYSDYRKIASLLFHIIPSILNPIIYGVQSSEVRHVL 301
Cdd:cd15942 238 PGSQDPLDGVVAVFYTTVTPLLNPVIYTLRNKEMKDAL 275

7tmA_OR5G-like

cd15414

olfactory receptor subfamily 5G and related proteins, member of the class A family of ...

25-309

9.22e-34

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320536 [Multi-domain] Cd Length: 285 Bit Score: 125.23 E-value: 9.22e-34

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  25 PVFVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKspSQRYISYVECVVQAFS 104
Cdd:cd15414   2 PLFLLFLLVYLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFV--EKKAISFLGCAAQMWF 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 105 THTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRC-RTFISNPFCDNAS 183
Cdd:cd15414  80 FGLFVAAECFLLASMAYDRYVAICNPLLYTVIMSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCgPNVINHFFCDIPP 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 184 LFKLSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSLYLIMLISGLIIIVLHR 263
Cdd:cd15414 160 LLSLSCADTQINKWVLFIMAGALGVLSGLIILVSYIYILIAILRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYVRPS 239

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 18859185 264 FPAYSDYRKIASLLFHIIPSILNPIIYGVQSSEVRHVLIQVLSFKK 309
Cdd:cd15414 240 SSSSLDLDKVVSVFYTAVIPMLNPLIYSLRNKEVKDALRRTIRRKM 285

7tmA_OR9G-like

cd15418

olfactory receptor subfamily 9G and related proteins, member of the class A family of ...

27-301

1.01e-33

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320540 [Multi-domain] Cd Length: 281 Bit Score: 124.89 E-value: 1.01e-33

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  27 FVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMD-ILKSPSqryISYVECVVQAFST 105
Cdd:cd15418   5 FVVFLLSYILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADcISKDKS---ISFAGCAAQFFFS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 106 HTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRC-RTFISNPFCDNASL 184
Cdd:cd15418  82 AGLAYSECFLLAAMAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCgDNIIDHFFCDLPPL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 185 FKLSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSLYLIMLISGLIIIVLHRF 264
Cdd:cd15418 162 VKLACDDTRVYELILYFILGFNVIAPTALILASYTFILAAILRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSRPSS 241

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 18859185 265 PAYSDYRKIASLLFHIIPSILNPIIYGVQSSEVRHVL 301
Cdd:cd15418 242 SHTPDRDKVVALFYTVVNPLLNPLIYSLRNKDVKEAL 278

7tmA_OR4Q2-like

cd15938

olfactory receptor 4Q2 and related proteins, member of the class A family of ...

27-290

1.56e-33

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320604 [Multi-domain] Cd Length: 265 Bit Score: 123.83 E-value: 1.56e-33

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  27 FVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKSpsQRYISYVECVVQAFSTH 106
Cdd:cd15938   4 FALFLLAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQ--RKAISYEACIAQLFFLH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 107 TYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRC-RTFISNPFCDNASLF 185
Cdd:cd15938  82 FVGAAEMFLLTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCgPNQVNNFFCDVPPVI 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 186 KLSCEDVTINNLYGLIYTVLLfgsSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSLYLIMLISgLIIIVLHRFP 265
Cdd:cd15938 162 KLACTDTCVTELLMVSNSGLI---STVCFVVLVTSYTTILVTIRSTEGRRKALSTCASHLMVVTLFFGP-CIFIYARPFS 237

                       250       260
                ....*....|....*....|....*
gi 18859185 266 AYSdYRKIASLLFHIIPSILNPIIY 290
Cdd:cd15938 238 TFP-VDKHVSVLYNVITPMLNPLIY 261

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

30-306

1.61e-33

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 124.15 E-value: 1.61e-33

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185    30 FLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKSpsQRYISYVECVVQAFSTHTYG 109
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFG--LREISFEACLTQMFFIHKFS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185   110 TTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRC-RTFISNPFCDNASLFKLS 188
Cdd:pfam13853  79 IMESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCgHHVLSHSYCLHMGLARLS 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185   189 CEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSLYLIMLISGLIIIVLHRFPAYS 268
Cdd:pfam13853 159 CADIKVNNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGHNV 238

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 18859185   269 DY--RKIASLLFHIIPSILNPIIYGVQSSEVRHVLIQVLS 306
Cdd:pfam13853 239 PPllQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRMLL 278

7tmA_OR52A-like

cd15955

olfactory receptor subfamily 52A and related proteins, member of the class A family of ...

29-297

6.98e-33

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320621 [Multi-domain] Cd Length: 276 Bit Score: 122.57 E-value: 6.98e-33

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  29 FFLLFYVAIMVlNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLmDILKSPSqRYISYVECVVQAFSTHTY 108
Cdd:cd15955   7 FCIMFLLAVLG-NCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKML-AIFWFQL-REISFNACLAQMFFIHTL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 109 GTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGL-TLRLSRCR-TFISNPFCDNASLFK 186
Cdd:cd15955  84 QAFESGILLAMALDRYVAICHPLRHSSILTPQVLLGIGVLVVVRAVVLIIPCPLLiKLRLHHFRsTVISHSYCEHMAVVK 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 187 LSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSLYLIMLISGLIIIVLHRFPA 266
Cdd:cd15955 164 LAADDVRVNKIYGLFVAFSILGFDIIFITTSYALIFRAVFRLPQKEARLKAFNTCTAHIFVFLLFYTLAFFSFFAHRFGH 243

                       250       260       270
                ....*....|....*....|....*....|...
gi 18859185 267 Y-SDYRKI-ASLLFHIIPSILNPIIYGVQSSEV 297
Cdd:cd15955 244 HvAPYVHIlLSNLYLLVPPVLNPIVYGVKTKQI 276

7tmA_OR5M-like

cd15412

olfactory receptor subfamily 5M and related proteins, member of the class A family of ...

25-303

8.56e-33

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320534 Cd Length: 279 Bit Score: 122.51 E-value: 8.56e-33

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  25 PVFVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKSpsQRYISYVECVVQAFS 104
Cdd:cd15412   2 LLFVLFLVIYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSE--KKTISFAGCFTQCYF 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 105 THTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRCRTFISNPF-CDNAS 183
Cdd:cd15412  80 FIALVITEYYMLAVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFyCADPP 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 184 LFKLSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSlyLIMLISGLIIIVLHR 263
Cdd:cd15412 160 LIKLSCSDTYVKETAMFIVAGFNLSSSLLIILISYLFILIAILRIRSAEGRCKAFSTCGSHLT--AVTIFYGTLFCMYLR 237

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 18859185 264 FPAYS--DYRKIASLLFHIIPSILNPIIYGVQSSEVRHVLIQ 303
Cdd:cd15412 238 PPSEEsvEQSKIVAVFYTFVSPMLNPLIYSLRNKDVKQALKK 279

7tmA_OR2Y-like

cd15433

olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...

26-301

1.66e-32

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320550 [Multi-domain] Cd Length: 277 Bit Score: 121.44 E-value: 1.66e-32

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  26 VFVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDiLKSPSQrYISYVECVVQAFST 105
Cdd:cd15433   3 LFVVVLIFYLLTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLAN-LRGPAL-TITRGGCVAQLFIS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 106 HTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRC-RTFISNPFCDNASL 184
Cdd:cd15433  81 LALGSAECVLLAVMAFDRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCgHRLLDHFFCEMPVF 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 185 FKLSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLsLYLIMLISGLIIIVLHRF 264
Cdd:cd15433 161 LKLACGDDETTEVQMFVARVVILLLPAALILGSYGHVAHAVLRIKSSAGRRRAFGTCGSHL-MVVFLFYGSAIYTYLQPI 239

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 18859185 265 PAYSDYR-KIASLLFHIIPSILNPIIYGVQSSEVRHVL 301
Cdd:cd15433 240 HRYSQAHgKFVSLFYTVMTPALNPLIYTLRNKDVKGAL 277

7tmA_OR2T-like

cd15421

olfactory receptor subfamily 2T and related proteins, member of the class A family of ...

27-297

2.55e-32

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320543 Cd Length: 277 Bit Score: 121.12 E-value: 2.55e-32

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  27 FVFFLLFYVAIMVL--NIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKSpsQRYISYVECVVQAFS 104
Cdd:cd15421   2 FLFSLILLIFLVALtgNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSG--RKSISFVGCGTQIFF 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 105 THTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRCRTF-ISNPFCDNAS 183
Cdd:cd15421  80 FLTLGGAECLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSReIHHFFCEVPA 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 184 LFKLSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHL---SLYLimlisGLIIIV 260
Cdd:cd15421 160 LLKLSCADTSAYETVVYVSGVLFLLIPFSLILASYALILLTVLRMRSAEGRKKALATCSSHLtvvSLYY-----GPAIFT 234

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 18859185 261 LHRFPAY--SDYRKIASLLFHIIPSILNPIIYGVQSSEV 297
Cdd:cd15421 235 YMRPGSYhsPEQDKVVSVFYTILTPMLNPLIYSLRNKEV 273

7tmA_OR2_unk

cd15424

olfactory receptor family 2, unknown subfamily, member of the class A family of ...

26-297

2.84e-32

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320544 [Multi-domain] Cd Length: 277 Bit Score: 121.00 E-value: 2.84e-32

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  26 VFVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKSpsQRYISYVECVVQAFST 105
Cdd:cd15424   3 LFVVILIIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAG--NGAISFARCTTQMYIA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 106 HTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRC-RTFISNPFCDNASL 184
Cdd:cd15424  81 LSLGSTECLLLGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCgPNHINHFFCELPVV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 185 FKLSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSLYLIMLISGLIIIVLHRF 264
Cdd:cd15424 161 LKLACADTHITEAIVFGAGVLILLVPLSVILTSYGLILASVLQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPRS 240

                       250       260       270
                ....*....|....*....|....*....|...
gi 18859185 265 PAYSDYRKIASLLFHIIPSILNPIIYGVQSSEV 297
Cdd:cd15424 241 GSTPDRDKQIAVFYIVITPLLNPIIYTLRNKDV 273

7tmA_OR3A-like

cd15233

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...

26-301

3.98e-32

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320361 [Multi-domain] Cd Length: 277 Bit Score: 120.67 E-value: 3.98e-32

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  26 VFVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKSpsQRYISYVECVVQAFST 105
Cdd:cd15233   3 LFVTFLLAYIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSH--KRTISYAACLSQLFFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 106 HTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRCR-TFISNPFCDNASL 184
Cdd:cd15233  81 HLLAGADCFLLTAMAYDRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGpNVINHFFCDLPPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 185 FKLSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSLYLIMLISGLIIIVLHRF 264
Cdd:cd15233 161 FQLSCSSTHLNELLLFVFAFFMALAPCVLIVVSYAHVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMRLGS 240

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 18859185 265 PAYSDYRKIASLLFHIIPSILNPIIYGVQSSEVRHVL 301
Cdd:cd15233 241 VYSSDKDKVIGILNTVLSPMLNPLIYSLRNKDVKGAL 277

7tmA_OR8B-like

cd15405

olfactory receptor subfamily 8B and related proteins, member of the class A family of ...

25-298

5.42e-32

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320527 [Multi-domain] Cd Length: 277 Bit Score: 120.21 E-value: 5.42e-32

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  25 PVFVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKspSQRYISYVECVVQAFS 104
Cdd:cd15405   2 PLFFLFLGIYVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVS--EKNTISYAGCMTQLFF 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 105 THTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRCRT-FISNPFCDNAS 183
Cdd:cd15405  80 FCFFVISECYVLTAMAYDRYVAICNPLLYTVTMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSnIINHYMCDILP 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 184 LFKLSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSLYLIMLISGLIIIVLHR 263
Cdd:cd15405 160 LLQLSCTSTYVNELVVFVVVGINIIVPSVTIFISYALILSNILHISSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPS 239

                       250       260       270
                ....*....|....*....|....*....|....*
gi 18859185 264 FPAYSDYRKIASLLFHIIPSILNPIIYGVQSSEVR 298
Cdd:cd15405 240 SVGSVNQGKVSSVFYTNVVPMLNPLIYSLRNKDVK 274

7tmA_OR8K-like

cd15413

olfactory receptor subfamily 8K and related proteins, member of the class A family of ...

25-301

1.70e-31

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320535 Cd Length: 279 Bit Score: 118.96 E-value: 1.70e-31

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  25 PVFVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKSpsQRYISYVECVVQAFS 104
Cdd:cd15413   2 PLFGLFLVIYLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVE--QNTISFYACATQLAF 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 105 THTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRCRTFISNPF-CDNAS 183
Cdd:cd15413  80 FLTFIISELFLLSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFyCDDLP 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 184 LFKLSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSLyLIMLISGLIIIVLHr 263
Cdd:cd15413 160 LLALSCSDTHEKELIILIFAGFNLISSLLIVLVSYLFILSAILRIRSAEGRQKAFSTCGSHLTV-VTIFYGTLIFMYLQ- 237

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 18859185 264 fPAYS---DYRKIASLLFHIIPSILNPIIYGVQSSEVRHVL 301
Cdd:cd15413 238 -PKSShslDTDKMASVFYTLVIPMLNPLIYSLRNKEVKDAL 277

7tmA_OR11G-like

cd15913

olfactory receptor OR11G and related proteins, member of the class A family of ...

27-290

3.43e-31

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320579 Cd Length: 270 Bit Score: 117.80 E-value: 3.43e-31

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  27 FVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKSPSQryISYVECVVQAFSTH 106
Cdd:cd15913   4 FSFFSVIYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKT--ISFSGCFLQFYFFF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 107 TYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRCRTFISNPF-CDNASLF 185
Cdd:cd15913  82 SLGTTECFFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVVLISQLPFCGPNIIDHFlCDPGPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 186 KLSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRALKTCSTHLSLYLIMLISGLIIIVLHRFP 265
Cdd:cd15913 162 ALSCVPAPGTELICYTLSSLIIFGTFLFILGSYTLVLRAVLRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMVMYVSPGSG 241

                       250       260
                ....*....|....*....|....*
gi 18859185 266 AYSDYRKIASLLFHIIPSILNPIIY 290
Cdd:cd15913 242 NSTGMQKIVTLFYSVVTPLLNPLIY 266

7tmA_OR4N-like

cd15937

olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...

26-290

1.15e-30

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320603 Cd Length: 267 Bit Score: 116.37 E-value: 1.15e-30

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  26 VFVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKSPsqRYISYVECVVQAFST 105
Cdd:cd15937   3 LFVLFLLFYLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSER--KTISYGGCMAQLFFL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 106 HTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRC-RTFISNPFCDNASL 184
Cdd:cd15937  81 HFLGAAEMFLLVAMAYDRYVAICKPLHYTTVVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCgPNVLDNFFCDITQV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 185 FKLSCEDVTINNLY-----GLIyTVLLFGSSMGSIAVTYIKitavcLVTKSKMLNSRALKTCSTHLSLYLIMLISGlIII 259
Cdd:cd15937 161 IKLACTNTYTVELLmfsnsGLV-ILLCFLLLLISYAFLLAK-----LRTHSSKGKSKAASTCITHIIIVFVMFGPA-IYI 233

                       250       260       270
                ....*....|....*....|....*....|.
gi 18859185 260 VLHRFPAYSdYRKIASLLFHIIPSILNPIIY 290
Cdd:cd15937 234 YARPFRSFP-MDKVVAVFHTVIFPLLNPMIY 263

7tmA_OR4Q3-like

cd15935

olfactory receptor 4Q3 and related proteins, member of the class A family of ...

26-290

2.91e-29

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320601 [Multi-domain] Cd Length: 268 Bit Score: 112.55 E-value: 2.91e-29

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  26 VFVFFLLFYVAIMVLNIgiFIVITTH---RSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKSpsQRYISYVECVVQA 102
Cdd:cd15935   3 LFVLVLACYAAILLGNL--LIVVTVHadpHLLQSPMYFFLANLSLIDMTLGSVAVPKVLADLLTC--GRTISFGGCMAQL 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 103 FSTHTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRC-RTFISNPFCDN 181
Cdd:cd15935  79 FFLHFLGGSEMLLLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCgPNELDNFYCDV 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 182 ASLFKLSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYiKITAVCLVTKSKMLNSRALKTCSTHLSlyLIMLISGLIIIVL 261
Cdd:cd15935 159 PQVIKLACMDTYVVEVLMVANSGLLSLVCFLVLLVSY-GIILTTLRGRFREGGGKALSTCSSHLT--VVSLIFVPCIFVY 235

                       250       260
                ....*....|....*....|....*....
gi 18859185 262 HRFPAYSDYRKIASLLFHIIPSILNPIIY 290
Cdd:cd15935 236 LRPFSSSSVDKVASVFYTLITPALNPLIY 264

7tm_classA_rhodopsin-like

cd00637

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...

27-294

1.42e-20

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.

Pssm-ID: 410626 [Multi-domain] Cd Length: 275 Bit Score: 89.27 E-value: 1.42e-20

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  27 FVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILksPSQRYISYVECVVQAFSTH 106
Cdd:cd00637   2 AVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLL--LGRWWFGDALCKLLGFLQS 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 107 TYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILigltLRLSRCRTFISNPFCDnaslfk 186
Cdd:cd00637  80 VSLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPP----LLGWGVYDYGGYCCCC------ 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 187 LSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKML--------------NSRALKTCSTHLSLYLIM- 251
Cdd:cd00637 150 LCWPDLTLSKAYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRRIRssssnssrrrrrrrERKVTKTLLIVVVVFLLCw 229

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 18859185 252 ---LISGLIIIVLHRFPAYSDYRKIASLLFHIIPSILNPIIYGVQS 294
Cdd:cd00637 230 lpyFILLLLDVFGPDPSPLPRILYFLALLLAYLNSAINPIIYAFFN 275

7tm_1

pfam00001

7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...

41-290

4.58e-20

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.

Pssm-ID: 459624 [Multi-domain] Cd Length: 256 Bit Score: 87.35 E-value: 4.58e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185    41 NIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILkSPSQRYISYVECVVQAFSTHTYGTTSHTILIIMA 120
Cdd:pfam00001   2 NLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYL-NHGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185   121 IDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFisILIGLTLRLSRCRTFISNPFCDNASLFKLSCedvtiNNLYGL 200
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLL--SLPPLLFGWTLTVPEGNVTVCFIDFPEDLSK-----PVSYTL 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185   201 IYTVLLFGSSMGSIAVTYIKITAVCLVTKSKM-------LNSRALKTCSTHLSLYLIM---LISGLIIIVLHRFPAYSDY 270
Cdd:pfam00001 154 LISVLGFLLPLLVILVCYTLIIRTLRKSASKQkssertqRRRKALKTLAVVVVVFILCwlpYHIVNLLDSLALDCELSRL 233

                         250       260
                  ....*....|....*....|...
gi 18859185   271 RKIASLLFHIIP---SILNPIIY 290
Cdd:pfam00001 234 LDKALSVTLWLAyvnSCLNPIIY 256

7tmA_TAAR2_3_4

cd15312

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...

27-291

2.00e-11

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320437 [Multi-domain] Cd Length: 289 Bit Score: 63.53 E-value: 2.00e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  27 FVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKSPsqRYISYVECVVQAFSTH 106
Cdd:cd15312   4 YLFMAGAILLTVFGNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVMPYSMVRSVESC--WYFGDLFCKIHSSLDM 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 107 TYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRCRTFISNPFCDNaslfk 186
Cdd:cd15312  82 MLSTTSIFHLCFIAVDRYYAVCDPLHYRTKITTPVIKVFLVISWSVPCLFAFGVVFSEVNLEGIEDYVALVSCTG----- 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 187 lSCEdVTINNLYGLIYTVLLF---GSSMGSIavtYIKITAVC-----------LVTKSKMLN-------SRALKTCSTHL 245
Cdd:cd15312 157 -SCV-LIFNKLWGVIASLIAFfipGTVMIGI---YIKIFFVArkhakvinnrpSVTKGDSKNklskkkeRKAAKTLSIVM 231

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 18859185 246 SLYLIMLISGLIIIVLHRFPAYSDYRKI--ASLLFHIIPSILNPIIYG 291
Cdd:cd15312 232 GVFLLCWLPFFVATLIDPFLNFSTPVDLfdALVWLGYFNSTCNPLIYG 279

7tmA_amine_R-like

cd14967

amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...

29-301

1.78e-10

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320098 [Multi-domain] Cd Length: 259 Bit Score: 60.27 E-value: 1.78e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  29 FFLLFYVAIMVL----NIGIFIVITTHRSLHEPMYMLFCNLPINDIL-GNSIMVPRLLMDILKSPsqrYISYVECVVQAF 103
Cdd:cd14967   1 LLAVFLSLIILVtvfgNLLVILAVYRNRRLRTVTNYFIVSLAVADLLvALLVMPFSAVYTLLGYW---PFGPVLCRFWIA 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 104 STHTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLfISILiGLTLRLSRCRTFISNPFCdnas 183
Cdd:cd14967  78 LDVLCCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLL-ISLP-PLVGWRDETQPSVVDCEC---- 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 184 lfklsceDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVClvtkskMLNSRALKTCSTHLSLYLIM----LISGLIII 259
Cdd:cd14967 152 -------EFTPNKIYVLVSSVISFFIPLLIMIVLYARIFRVA------RRELKAAKTLAIIVGAFLLCwlpfFIIYLVSA 218

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 18859185 260 VLHRFPAYSDYRKIASLLfHIIPSILNPIIYGVQSSEVRHVL 301
Cdd:cd14967 219 FCPPDCVPPILYAVFFWL-GYLNSALNPIIYALFNRDFRRAF 259

7tmA_Opsins_type2_animals

cd14969

type 2 opsins in animals, member of the class A family of seven-transmembrane G ...

26-156

4.55e-09

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.

Pssm-ID: 381741 [Multi-domain] Cd Length: 284 Bit Score: 56.45 E-value: 4.55e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  26 VFVFFLLFYVAI-MVLNIGIFIVITTHRSLHEPMYMLFCNLPIND----ILGNSIMVPRLLMDilkspsQRYISYVECVV 100
Cdd:cd14969   2 VLAVYLSLIGVLgVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADllmsVVGYPLSFYSNLSG------RWSFGDPGCVI 75

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 18859185 101 QAFSTHTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLsALAWGIALLF 156
Cdd:cd14969  76 YGFAVTFLGLVSISTLAALAFERYLVIVRPLKAFRLSKRRALILI-AFIWLYGLFW 130

7tmA_EDG-like

cd14972

endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...

28-301

5.04e-09

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.

Pssm-ID: 341317 [Multi-domain] Cd Length: 275 Bit Score: 56.15 E-value: 5.04e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  28 VFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKSPSQRYISYVECVVQAFSTht 107
Cdd:cd14972   3 VVAIVLGVFIVVENSLVLAAIIKNRRLHKPMYILIANLAAADLLAGIAFVFTFLSVLLVSLTPSPATWLLRKGSLVLS-- 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 108 yGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIgltlrlsrcrtFISNpfCDNASLFKL 187
Cdd:cd14972  81 -LLASAYSLLAIAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLALLPV-----------LGWN--CVLCDQESC 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 188 SCEDVTINNLYGLIYTVLLFgSSMGSIAVTYIKITAV-------------CLVTKSKMLNSRALKTCSTHLSLYLIM--- 251
Cdd:cd14972 147 SPLGPGLPKSYLVLILVFFF-IALVIIVFLYVRIFWClwrhanaiaarqeAAVPAQPSTSRKLAKTVVIVLGVFLVCwlp 225

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 18859185 252 LISGLIIIVLHRFPAYSDYRKIASLLFHIIPSILNPIIYGVQSSEVRHVL 301
Cdd:cd14972 226 LLILLVLDVLCPSVCDIQAVFYYFLVLALLNSAINPIIYAFRLKEMRRAV 275

7tmA_TAARs

cd15055

trace amine-associated receptors, member of the class A family of seven-transmembrane G ...

27-224

6.26e-09

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320183 [Multi-domain] Cd Length: 285 Bit Score: 56.02 E-value: 6.26e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  27 FVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILgnsimVPRLLM--DILKS-PSQRYISYVECVVQAF 103
Cdd:cd15055   4 YIVLSSISLLTVLGNLLVIISISHFKQLHTPTNLLLLSLAVADFL-----VGLLVMpfSMIRSiETCWYFGDTFCKLHSS 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 104 STHTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRCRTFISnpfCDNAS 183
Cdd:cd15055  79 LDYILTSASIFNLVLIAIDRYVAVCDPLLYPTKITIRRVKICICLCWFVSALYSSVLLYDNLNQPGLIRYNS---CYGEC 155

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 18859185 184 LFklscedvTINNLYGLIYTVLLFGSSMGSIAVTYIKITAV 224
Cdd:cd15055 156 VV-------VVNFIWGVVDLVLTFILPCTVMIVLYMRIFVV 189

7tmA_capaR

cd15134

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...

25-156

5.42e-08

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.

Pssm-ID: 320262 [Multi-domain] Cd Length: 298 Bit Score: 53.10 E-value: 5.42e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  25 PVFVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILkspsQRY---ISYVECVVQ 101
Cdd:cd15134   2 PITIIYGIIFVTGVVGNLCTCIVIARNRSMHTATNYYLFSLAVSDLLLLILGLPFELYTIW----QQYpwvFGEVFCKLR 77

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 18859185 102 AFSTHTygTTSHTILIIMA--IDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLF 156
Cdd:cd15134  78 AFLSEM--SSYASVLTITAfsVERYLAICHPLRSHTMSKLSRAIRIIIAIWIIAFVC 132

7tmA_ETH-R

cd14997

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...

32-164

1.75e-07

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320128 [Multi-domain] Cd Length: 294 Bit Score: 51.52 E-value: 1.75e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  32 LFYVAIMVL----NIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDiLKSPSQRYISYVECVVQAFSTHT 107
Cdd:cd14997   5 VVYGVIFVVgvlgNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPVALVE-TWAREPWLLGEFMCKLVPFVELT 83

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 18859185 108 YGTTShtILIIMAI--DRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLT 164
Cdd:cd14997  84 VAHAS--VLTILAIsfERYYAICHPLQAKYVCTKRRALVIIALIWLLALLTSSPVLFIT 140

7tmA_NPYR-like

cd15203

neuropeptide Y receptors and related proteins, member of the class A family of ...

28-291

2.15e-07

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.

Pssm-ID: 320331 [Multi-domain] Cd Length: 293 Bit Score: 51.45 E-value: 2.15e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  28 VFFLLFYVAIMVL----NIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILK------SPSQRYISYVE 97
Cdd:cd15203   1 IILILLYGLIIVLgvvgNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLVSLPFTLIYTLTknwpfgSILCKLVPSLQ 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  98 CVVQAFSTHTygttshtiLIIMAIDRYVAICNPLRyqTIMTNKTVITLSALAWGIALLfisiligLTLRLSRCRTFISNP 177
Cdd:cd15203  81 GVSIFVSTLT--------LTAIAIDRYQLIVYPTR--PRMSKRHALLIIALIWILSLL-------LSLPLAIFQELSDVP 143

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 178 FcDNASLFKLSCEDVTINNLYGLIYT----VLLFGSSMGSIAVTYIKITAV---------CLVTKSKMLNSRALK-TCST 243
Cdd:cd15203 144 I-EILPYCGYFCTESWPSSSSRLIYTisvlVLQFVIPLLIISFCYFRISLKlrkrvkkkrGKRTLSSRRRRSELRrKRRT 222

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 18859185 244 HLSLYLIMLISG----------LIIIVLHRFPAYSDYRKIASLLFHII---PSILNPIIYG 291
Cdd:cd15203 223 NRLLIAMVVVFAvcwlplnlfnLLRDFEPLPQIDGRHFYLIFLICHLIamsSACVNPLLYG 283

7tmA_Vasopressin_Oxytocin

cd15196

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...

26-156

3.82e-07

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320324 [Multi-domain] Cd Length: 264 Bit Score: 50.31 E-value: 3.82e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  26 VFVFFLLFYVAImVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSI-MVPRLLMDI----LKSPSQ-RYISYVECV 99
Cdd:cd15196   4 IAVLATILVLAL-FGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVALFnVLPQLIWDItyrfYGGDLLcRLVKYLQVV 82

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 18859185 100 VQAFSTHtygttshtILIIMAIDRYVAICNPLRYQTImTNKTVITLSALAWGIALLF 156
Cdd:cd15196  83 GMYASSY--------VLVATAIDRYIAICHPLSSHRW-TSRRVHLMVAIAWVLSLLL 130

7tmA_CCKR-like

cd14993

cholecystokinin receptors and related proteins, member of the class A family of ...

28-221

2.08e-06

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.

Pssm-ID: 320124 [Multi-domain] Cd Length: 296 Bit Score: 48.36 E-value: 2.08e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  28 VFFLLFYVAIMVL----NIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVP-RLLMDILK-----SPSQRYISYVE 97
Cdd:cd14993   1 IVLIVLYVVVFLLalvgNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPlTLLENVYRpwvfgEVLCKAVPYLQ 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  98 CVVQAFSTHTygttshtiLIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWgiallFISILIGLTLRLSRCRTFISNP 177
Cdd:cd14993  81 GVSVSASVLT--------LVAISIDRYLAICYPLKARRVSTKRRARIIIVAIW-----VIAIIIMLPLLVVYELEEIISS 147

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 18859185 178 FCDNASLFklSCEDVTINNLYGLIYTVLLFGSS----MGSIAVTYIKI 221
Cdd:cd14993 148 EPGTITIY--ICTEDWPSPELRKAYNVALFVVLyvlpLLIISVAYSLI 193

7tmA_NTSR-like

cd14979

neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...

24-167

4.74e-06

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320110 [Multi-domain] Cd Length: 300 Bit Score: 47.35 E-value: 4.74e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  24 YPVFVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKSPSQRYISYVeCVVQAF 103
Cdd:cd14979   1 VLVTAIYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELYNFWWQYPWAFGDGG-CKLYYF 79

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 18859185 104 STHTygTTSHTILIIMA--IDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFiSILIGLTLRL 167
Cdd:cd14979  80 LFEA--CTYATVLTIVAlsVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILC-AIPILFLMGI 142

7tmA_QRFPR

cd15205

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...

28-158

5.39e-06

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.

Pssm-ID: 320333 [Multi-domain] Cd Length: 298 Bit Score: 47.08 E-value: 5.39e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  28 VFFLLFYVAIMVL----NIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKSpsQRYISYVECVVQAF 103
Cdd:cd15205   1 TAFVITYVLIFVLalfgNSLVIYVVTRKRAMRTATNIFICSLALSDLLITFFCIPFTLLQNISS--NWLGGAFMCKMVPF 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 18859185 104 STHTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFIS 158
Cdd:cd15205  79 VQSTAVVTSILTMTCIAVERHQGIVHPLKMKWQYTNRRAFTMLGLVWIVSVIVGS 133

7tmA_TAAR5

cd15318

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...

35-161

1.01e-05

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320441 [Multi-domain] Cd Length: 282 Bit Score: 46.39 E-value: 1.01e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  35 VAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPrlLMDILKSPSQRYISYVECVVQAFSTHTYGTTSHT 114
Cdd:cd15318  12 LIIVLGNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTVLP--FSTIRSVESCWYFGDSFCRLHTCLDTLFCLTSIF 89

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 18859185 115 ILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILI 161
Cdd:cd15318  90 HLCFISIDRHCAICDPLLYPSKFTIRVACIFIAAGWLVPTVYTSVFL 136

7tmA_SREB-like

cd15005

super conserved receptor expressed in brain and related proteins, member of the class A family ...

26-155

1.17e-05

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320134 [Multi-domain] Cd Length: 329 Bit Score: 46.30 E-value: 1.17e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  26 VFVFFLLFYVAIMVLNIGIF-IVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKSPSQRYiSYVECVVQAFS 104
Cdd:cd15005   2 LKLTTLGLILCVSLAGNLLFsVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPFVMASVRHGSGWIY-GALSCKVIAFL 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 18859185 105 THTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALL 155
Cdd:cd15005  81 AVLFCFHSAFTLFCIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAWTLSVA 131

7tmA_D1A_dopamine_R

cd15320

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...

110-221

1.27e-05

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.

Pssm-ID: 320443 [Multi-domain] Cd Length: 319 Bit Score: 46.15 E-value: 1.27e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 110 TTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRCRTFISNpfcdNASLFKLSC 189
Cdd:cd15320  86 TASILNLCVISVDRYWAISSPFRYERKMTPKVAFIMISVAWTLSVLISFIPVQLNWHKAKPTSFLDL----NASLRDLTM 161

                        90       100       110
                ....*....|....*....|....*....|....
gi 18859185 190 E--DVTINNLYGLIYTVLLFGSSMGSIAVTYIKI 221
Cdd:cd15320 162 DncDSSLNRTYAISSSLISFYIPVAIMIVTYTRI 195

7tmA_Opsin_Gq_invertebrates

cd15337

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...

24-155

1.35e-05

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320459 [Multi-domain] Cd Length: 292 Bit Score: 45.77 E-value: 1.35e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  24 YPVFVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDiLGNSIMVPRLLMDIlKSPSQRYI-SYVECVVQA 102
Cdd:cd15337   1 YLIGIYIAIVGILGVIGNLLVIYLFSKTKSLRTPSNMFIINLAISD-FGFSAVNGFPLKTI-SSFNKKWIwGKVACELYG 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 18859185 103 FSTHTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALL 155
Cdd:cd15337  79 FAGGIFGFMSITTLAAISIDRYLVIAKPLEAMKKMTFKRAFIMIIIIWLWSLL 131

7tmA_S1PR

cd15102

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...

28-301

1.54e-05

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).

Pssm-ID: 320230 [Multi-domain] Cd Length: 270 Bit Score: 45.54 E-value: 1.54e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  28 VFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLmdiLKSPSQRYISYVECVVQAFSTHT 107
Cdd:cd15102   5 VVFVAICCFIVLENLLVLIAIWRHMKFHRPMYYFLGNLALSDLLAGAAYLANIL---LSGARTLRLSPAQWFLREGSMFV 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 108 YGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKtVITLSALAWGIALLfisiLIGLTL-------RLSRCRTFISnpfcd 180
Cdd:cd15102  82 ALSASVFSLLAIAIERHLTMAKMKPYGASKTSR-VLLLIGACWLISLL----LGGLPIlgwnclgALDACSTVLP----- 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 181 naslfklscedvtinnLYG---LIYTVLLFGSSMGSIAVTYIKItaVCLVTKSKMLNSRA---------LKTCSTHLSLY 248
Cdd:cd15102 152 ----------------LYSkhyVLFCVTIFAGILAAIVALYARI--YCLVRASGRKATRAsasprslalLKTVLIVLLVF 213

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 18859185 249 LIMLISGLIIIVLHRF-PAYSD---YRKIASLLFHIIPSILNPIIYGVQSSEVRHVL 301
Cdd:cd15102 214 IACWGPLFILLLLDVAcPVKTCpilYKADWFLALAVLNSALNPIIYTLRSRELRRAV 270

7tmA_alpha1A_AR

cd15325

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...

26-159

1.85e-05

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320448 [Multi-domain] Cd Length: 261 Bit Score: 45.27 E-value: 1.85e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  26 VFVFFLLFYVaimVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVP-RLLMDILkspSQRYISYVECVVQAFS 104
Cdd:cd15325   6 ILGGFILFGV---LGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPfSAIFEIL---GYWAFGRVFCNIWAAV 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 18859185 105 THTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLfISI 159
Cdd:cd15325  80 DVLCCTASIMSLCIISIDRYIGVSYPLRYPSIMTERRGLLALLCVWVLSLV-ISI 133

7tmA_D1-like_dopamine_R

cd15057

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...

110-221

1.98e-05

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320185 [Multi-domain] Cd Length: 299 Bit Score: 45.50 E-value: 1.98e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 110 TTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALL--FISILIGL---TLRLSRCRTFISNPFCdnasl 184
Cdd:cd15057  85 TASILNLCVISVDRYWAISSPFRYERRMTRRRAFIMIAVAWTLSALisFIPVQLGWhraDDTSEALALYADPCQC----- 159

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 18859185 185 fklsceDVTINNLYGLIYTVLLFGSSMGSIAVTYIKI 221
Cdd:cd15057 160 ------DSSLNRTYAISSSLISFYIPVAIMIVTYTRI 190

7tmA_5-HT1E

cd15335

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...

38-159

2.06e-05

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320457 [Multi-domain] Cd Length: 258 Bit Score: 45.30 E-value: 2.06e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  38 MVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKspSQRYISYVECVVQAFSTHTYGTTSHTILI 117
Cdd:cd15335  15 TVLNSAVIAAICTTKKLHQPANYLICSLAVTDFLVAVLVMPLSITYIVM--DTWTLGYFICEIWLSVDMTCCTCSILHLC 92

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 18859185 118 IMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIAlLFISI 159
Cdd:cd15335  93 VIALDRYWAITDAIEYARKRTAKRAGLMILTVWTIS-IFISI 133

7tmA_GPR119_R_insulinotropic_receptor

cd15104

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...

64-163

2.64e-05

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320232 [Multi-domain] Cd Length: 283 Bit Score: 45.06 E-value: 2.64e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  64 NLPINDILgNSIMVPRLLMDILKSPSQRYISyVECVVQAFSTHTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVI 143
Cdd:cd15104  41 NLAIADFL-VGLAIPGLATDELLSDGENTQK-VLCLLRMCFVITSCAASVLSLAAIAFDRYLALKQPLRYKQIMTGKSAG 118

                        90       100
                ....*....|....*....|
gi 18859185 144 TLSALAWgiallFISILIGL 163
Cdd:cd15104 119 ALIAGLW-----LYSGLIGF 133

7tmA_alpha1_AR

cd15062

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...

26-159

3.33e-05

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320190 [Multi-domain] Cd Length: 261 Bit Score: 44.40 E-value: 3.33e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  26 VFVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPrlLMDILKSPSQRYISYVECVVQAFST 105
Cdd:cd15062   3 VGVALGAFILFAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLP--FSATLEVLGYWAFGRIFCDVWAAVD 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 18859185 106 HTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLfISI 159
Cdd:cd15062  81 VLCCTASIMSLCVISVDRYIGVRYPLNYPTIVTARRATVALLIVWVLSLV-ISI 133

7tmA_TAAR1

cd15314

trace amine-associated receptor 1 and similar receptors, member of the class A family of ...

24-156

5.28e-05

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320438 [Multi-domain] Cd Length: 282 Bit Score: 44.15 E-value: 5.28e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  24 YPVFVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDIL-GNSIMVPRLLMDIlksPSQRYISYVECVVQA 102
Cdd:cd15314   1 VLLYIFLGLISLVTVCGNLLVIISIAHFKQLHTPTNYLILSLAVADLLvGGLVMPPSMVRSV---ETCWYFGDLFCKIHS 77

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 18859185 103 FSTHTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLF 156
Cdd:cd15314  78 SFDITLCTASILNLCFISIDRYYAVCQPLLYRSKITVRVVLVMILISWSVSALV 131

7tmA_MCR

cd15103

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...

30-150

5.51e-05

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320231 [Multi-domain] Cd Length: 270 Bit Score: 44.02 E-value: 5.51e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  30 FLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGN------SIMVPRLLMDILKsPSQRYISYVECVVQAF 103
Cdd:cd15103   7 FLTLGIVSLLENILVILAIAKNKNLHSPMYFFICSLAVADMLVSvsnaleTIVIILLNNGYLV-PRDSFEQHIDNVIDSM 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 18859185 104 STHTYgTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAW 150
Cdd:cd15103  86 ICSSL-LASICSLLAIAVDRYITIFYALRYHSIMTVRRAGVIITAIW 131

7tmA_D1B_dopamine_R

cd15319

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...

110-221

7.72e-05

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.

Pssm-ID: 320442 [Multi-domain] Cd Length: 317 Bit Score: 43.79 E-value: 7.72e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 110 TTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRLSRCRTFISNPFCDNASLFKLSC 189
Cdd:cd15319  85 TASILNLCVISVDRYWAISSPFRYERKMTQRVALVMISVAWTLSVLISFIPVQLNWHKDSGDDWVGLHNSSISRQVEENC 164

                        90       100       110
                ....*....|....*....|....*....|..
gi 18859185 190 eDVTINNLYGLIYTVLLFGSSMGSIAVTYIKI 221
Cdd:cd15319 165 -DSSLNRTYAISSSLISFYIPVAIMIVTYTRI 195

7tmA_Histamine_H2R

cd15051

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...

110-224

1.15e-04

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320179 [Multi-domain] Cd Length: 287 Bit Score: 43.09 E-value: 1.15e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 110 TTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALL--FISILIGLTLRLSRCRTfISNPfcdNASLFKL 187
Cdd:cd15051  85 TASILNLFAISLDRYLAITAPLRYPSRVTPRRVAIALAAIWVVSLAvsFLPIHLGWNTPDGRVQN-GDTP---NQCRFEL 160

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 18859185 188 scedvtiNNLYGLIYTVLLFGSSMGSIAVTYIKITAV 224
Cdd:cd15051 161 -------NPPYVLLVAIGTFYLPLLIMCGVYLRIFRI 190

7tmA_prokineticin-R

cd15204

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...

34-156

1.74e-04

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.

Pssm-ID: 320332 [Multi-domain] Cd Length: 288 Bit Score: 42.65 E-value: 1.74e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  34 YVAIMVL----NIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPrLLMD--ILKSPSQRY-------ISYVECVV 100
Cdd:cd15204   7 YVLIMLVcgvgNLLLIAVLARYKKLRTLTNLLIANLALSDFLVAVFCLP-FEMDyyVVRQRSWTHgdvlcavVNYLRTVS 85

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 18859185 101 QAFSTHTygttshtiLIIMAIDRYVAICNPLRyqTIMTNKTVITLSALAWGIALLF 156
Cdd:cd15204  86 LYVSTNA--------LLVIAIDRYLVIVHPLK--PRMKRRTACVVIALVWVVSLLL 131

7tmA_Opsin5_neuropsin

cd15074

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...

28-156

1.78e-04

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.

Pssm-ID: 320202 [Multi-domain] Cd Length: 284 Bit Score: 42.65 E-value: 1.78e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  28 VFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPrllMDILKSPSQRYI-SYVECVVQAFSTH 106
Cdd:cd15074   5 IYLTVIGILSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYP---LAIISAFAHRWLfGDIGCVFYGFCGF 81

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 18859185 107 TYGTTSHTILIIMAIDRYVAICNPlRYQTIMTNKTVITLSALAWGIALLF 156
Cdd:cd15074  82 LFGCCSINTLTAISIYRYLKICHP-PYGPKLSRRHVCIVIVAIWLYALFW 130

7tmA_Adenosine_R

cd14968

adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...

24-164

2.11e-04

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.

Pssm-ID: 341316 [Multi-domain] Cd Length: 285 Bit Score: 42.24 E-value: 2.11e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  24 YPVFVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKSPSQRYIS-YVECVVQA 102
Cdd:cd14968   1 AVYIVLEVLIAVLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIPLAILISLGLPTNFHGClFMACLVLV 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 18859185 103 FsthtygTTSHTI-LIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWgiallFISILIGLT 164
Cdd:cd14968  81 L------TQSSIFsLLAIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCW-----VLSFLVGLT 132

7tmA_alpha1D_AR

cd15327

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...

26-298

2.21e-04

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320450 [Multi-domain] Cd Length: 261 Bit Score: 42.21 E-value: 2.21e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  26 VFVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPrlLMDILKSPSQRYISYVECVVQAFST 105
Cdd:cd15327   3 VGVFLAIFILMAIVGNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTVLP--FSATLEVLGFWAFGRVFCDIWAAVD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 106 HTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLF-ISILIGLtlrlsrcrtfiSNPFCDNASL 184
Cdd:cd15327  81 VLCCTASILSLCVISVDRYVGVKHSLKYPTIMTERKAGVILVLLWVSSMVIsIGPLLGW-----------KEPPPPDESI 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 185 FKLSCEDVtinnlYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKmlnSRALKTCSTHLSLYLIMLISGLIIIVLHR- 263
Cdd:cd15327 150 CSITEEPG-----YALFSSLFSFYLPLMVILVMYFRVYVVALKFSRE---KKAAKTLAIVVGVFILCWFPFFFVLPLGSf 221

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 18859185 264 FPAYSDYRKIASLLFHI--IPSILNPIIYGVQSSEVR 298
Cdd:cd15327 222 FPALKPSEMVFKVIFWLgyFNSCVNPIIYPCSSKEFK 258

7tmA_FMRFamide_R-like

cd14978

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...

38-206

2.38e-04

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.

Pssm-ID: 410630 [Multi-domain] Cd Length: 299 Bit Score: 42.23 E-value: 2.38e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  38 MVLNIGIFIVITtHRSLHEPMYMLFCNLPINDIL---GNSIMVPRLLMDILKSPSQRYISYVECVVQAFSTHTYGTTSHT 114
Cdd:cd14978  15 IIGNILNLVVLT-RKSMRSSTNVYLAALAVSDILvllSALPLFLLPYIADYSSSFLSYFYAYFLPYIYPLANTFQTASVW 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 115 ILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLtlrlsrcRTFISNPFCDNASLFKLSCEDVTI 194
Cdd:cd14978  94 LTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFFE-------YEVVECENCNNNSYYYVIPTLLRQ 166

                       170
                ....*....|..
gi 18859185 195 NNLYGLIYTVLL 206
Cdd:cd14978 167 NETYLLKYYFWL 178

7tmA_MC3R

cd15352

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...

30-150

3.19e-04

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320474 [Multi-domain] Cd Length: 272 Bit Score: 41.80 E-value: 3.19e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  30 FLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGN------SIMVPRLLMDILKSPSQrYISYVECVVQAF 103
Cdd:cd15352   7 FLTLGIVSLLENILVILAVVKNKNLHSPMYFFLCSLAVADMLVSvsnsleTIMIAVLNSGYLVISDQ-FIQHMDNVFDSM 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 18859185 104 STHTYgTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAW 150
Cdd:cd15352  86 ICISL-VASICNLLAIAVDRYVTIFYALRYHSIMTVRKALVLIAVIW 131

7tmA_Vasopressin-like

cd14986

vasopressin receptors and its related G protein-coupled receptors, member of the class A ...

34-156

3.54e-04

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.

Pssm-ID: 320117 [Multi-domain] Cd Length: 295 Bit Score: 41.59 E-value: 3.54e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  34 YVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILgnsIMVPRLLMDILKSPSQRY---------ISYVECVVQAFS 104
Cdd:cd14986  11 FVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLV---VAFFTVLTQIIWEATGEWvagdvlcriVKYLQVVGLFAS 87

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 18859185 105 THtygttshtILIIMAIDRYVAICNPLryQTIMTNKTVITLSALAWGIALLF 156
Cdd:cd14986  88 TY--------ILVSMSLDRYQAIVKPM--SSLKPRKRARLMIVVAWVLSFLF 129

7tmA_Prostanoid_R

cd14981

G protein-coupled receptors for prostanoids, member of the class A family of ...

28-163

4.29e-04

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.

Pssm-ID: 320112 [Multi-domain] Cd Length: 288 Bit Score: 41.46 E-value: 4.29e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  28 VFFLLFYVAIMVLNIGIFIVITTHRSLHE--PMYMLFCNLPINDILGNSIMVPRLLMdilkspsqRYISYVE-------C 98
Cdd:cd14981   5 APPALMFVFGVLGNLLALIVLARSSKSHKwsVFYRLVAGLAITDLLGILLTSPVVLA--------VYASNFEwdggqplC 76

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 18859185  99 VVQAFSTHTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISI-LIGL 163
Cdd:cd14981  77 DYFGFMMSFFGLSSLLIVCAMAVERFLAITHPFFYNSHVKKRRARLMLGAVWAFALLIASLpLLGL 142

7tmA_TAAR5-like

cd15317

trace amine-associated receptor 5 and similar receptors, member of the class A family of ...

29-161

5.01e-04

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320440 [Multi-domain] Cd Length: 290 Bit Score: 41.28 E-value: 5.01e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  29 FFLLFYVAIMVL-NIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPrlLMDILKSPSQRYISYVECVVQAFSTHT 107
Cdd:cd15317   5 IVLVLAMLITVSgNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMP--FSMIRTVETCWYFGDLFCKFHTGLDLL 82

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 18859185 108 YGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILI 161
Cdd:cd15317  83 LCTTSIFHLCFIAIDRYYAVCDPLRYPSKITVQVAWRFIAIGWLVPGIYTFGLI 136

7tmA_OT_R

cd15387

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...

41-156

5.27e-04

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320509 [Multi-domain] Cd Length: 297 Bit Score: 40.96 E-value: 5.27e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  41 NIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMV-PRLLMDI---LKSPS--QRYISYVECVVQAFSTHtygttsht 114
Cdd:cd15387  18 NICVLLAIHTTRHKHSRMYFFMKHLSIADLVVAVFQVlPQLIWDItfrFYGPDflCRLVKYLQVVGMFASTY-------- 89

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 18859185 115 ILIIMAIDRYVAICNPLRYQTIMTNKTVITLSalaWGIALLF 156
Cdd:cd15387  90 MLLLMSIDRCLAICQPLRSLHRRSDRVYVLFS---WLLSLVF 128

7tmA_Melanopsin-like

cd15083

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...

28-156

5.64e-04

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320211 [Multi-domain] Cd Length: 291 Bit Score: 40.78 E-value: 5.64e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  28 VFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILgnsIMVPRLLMDILKSPSQRYI-SYVECVVQAFSTH 106
Cdd:cd15083   5 IFILIIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFL---MCILNCPLMVISSFSGRWIfGKTGCDMYGFSGG 81

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 18859185 107 TYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKT------VITLSALAWGIALLF 156
Cdd:cd15083  82 LFGIMSINTLAAIAVDRYLVITRPMKASVRISHRRaliviaVVWLYSLLWVLPPLF 137

7tmA_5-HT1_5_7

cd15064

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...

41-159

6.54e-04

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320192 [Multi-domain] Cd Length: 258 Bit Score: 40.78 E-value: 6.54e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  41 NIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPrllMDILKSPSQRYI-SYVECVVQAFSTHTYGTTSHTILIIM 119
Cdd:cd15064  18 NALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMP---LSAVYELTGRWIlGQVLCDIWISLDVTCCTASILHLCVI 94

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 18859185 120 AIDRYVAICNPLRYQTIMTNKTVITLSALAWGIAlLFISI 159
Cdd:cd15064  95 ALDRYWAITDAVEYAHKRTPKRAAVMIALVWTLS-ICISL 133

7tmA_SREB3_GPR173

cd15217

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...

24-154

7.30e-04

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320345 [Multi-domain] Cd Length: 329 Bit Score: 40.70 E-value: 7.30e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  24 YPVFVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKSPSQRYiSYVECVVQAF 103
Cdd:cd15217   1 YVKLVLLGLIICVSLAGNLIVSLLVLKDRALHKAPYYFLLDLCLADTIRSAVCFPFVLVSIRNGSAWTY-SVLSCKIVAF 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 18859185 104 STHTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIAL 154
Cdd:cd15217  80 MAVLFCFHAAFMLFCISVTRYMAIAHHRFYSKRMTFWTCIAVICMVWTLSV 130

7tmA_Parapinopsin

cd15075

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...

32-150

7.96e-04

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.

Pssm-ID: 320203 [Multi-domain] Cd Length: 279 Bit Score: 40.53 E-value: 7.96e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  32 LFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPIND----ILGNSIMVprllmdilKSPSQRYISY--VECVVQAFST 105
Cdd:cd15075   9 VFSIASVVLNATVIIVTLRHKQLRQPLNYALVNLAVADlgttVFGGLLSV--------VTNAVGYFNLgrVGCVLEGFAV 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 18859185 106 HTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLsALAW 150
Cdd:cd15075  81 AFFGIAALCTVAVIAVDRLFVVCKPLGTLTFQTRHALAGI-ASSW 124

7tmA_Beta1_AR

cd15958

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...

110-161

8.09e-04

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.

Pssm-ID: 320624 [Multi-domain] Cd Length: 298 Bit Score: 40.66 E-value: 8.09e-04

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 18859185 110 TTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALL--FISILI 161
Cdd:cd15958  85 TASIETLCVIAIDRYLAITSPFRYQSLLTRARAKGIVCTVWAISALvsFLPIMM 138

7tmA_MC1R

cd15351

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...

30-161

8.16e-04

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320473 [Multi-domain] Cd Length: 271 Bit Score: 40.55 E-value: 8.16e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  30 FLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDIL-GNSIMVPRLLMDILKS----PSQRYISYVECVVQAFS 104
Cdd:cd15351   7 FLFLGLVSLVENILVVVAIAKNRNLHSPMYYFICCLAVSDMLvSVSNLIETLFMLLLEHgvlvCRAPMLQHMDNVIDTMI 86

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 18859185 105 THTYgTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILI 161
Cdd:cd15351  87 CSSV-VSSLSFLGAIAVDRYITIFYALRYHSIMTLQRAVNAIAGIWLASTVSSTLFI 142

7tmA_Trissin_R

cd15012

trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...

25-156

8.27e-04

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320140 [Multi-domain] Cd Length: 277 Bit Score: 40.51 E-value: 8.27e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  25 PVFVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILkSPSQrYISYVECVVQAFS 104
Cdd:cd15012   1 IFIILYTLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYL-IPSW-PFGEVLCRMYQFV 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 18859185 105 THTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLF 156
Cdd:cd15012  79 HSLSYTASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAVY 130

7tmA_MC4R

cd15353

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...

30-150

1.04e-03

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320475 [Multi-domain] Cd Length: 269 Bit Score: 39.89 E-value: 1.04e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  30 FLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDIL----GNSIMVPRLLMDILKSPSQRYISYVECVVQAFST 105
Cdd:cd15353   7 FVTLGIVSLLENILVIAAIAKNKNLHSPMYFFICSLAVADMLvsvsNGSETVVITLLNGNDTDAQSFTVNIDNVIDSVIC 86

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 18859185 106 HTYGTTSHTILIImAIDRYVAICNPLRYQTIMTNKTVITLSALAW 150
Cdd:cd15353  87 SSLLASICSLLSI-AVDRYFTIFYALQYHNIMTVRRAGVIITCIW 130

7tmA_5-HT1F

cd15334

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...

26-159

1.16e-03

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320456 [Multi-domain] Cd Length: 259 Bit Score: 39.93 E-value: 1.16e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  26 VFVFFLLFYVAIMV--LNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKspSQRYISYVECVVQAF 103
Cdd:cd15334   1 ILISLTLSILALMTtaINSLVITAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIMYIVK--ETWIMGQVVCDIWLS 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 18859185 104 STHTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIAlLFISI 159
Cdd:cd15334  79 VDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMIAVVWIIS-IFISM 133

7tmA_Adenosine_R_A2B

cd15069

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...

116-299

1.17e-03

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.

Pssm-ID: 320197 [Multi-domain] Cd Length: 294 Bit Score: 39.92 E-value: 1.17e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 116 LIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWgiallFISILIGLTLRLSRCRTFISNPFCDNAS---------LFK 186
Cdd:cd15069  89 LLAVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLW-----VLAFGIGLTPFLGWNKAMSATNNSTNPAdhgtnhsccLIS 163

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 187 LSCEDVTIN------NLYGLIYTVLLFgssmgsIAVTYIKITAVC---LVTKSKMLNSRALKTCSTHL--SLYLIMLISG 255
Cdd:cd15069 164 CLFENVVPMsymvyfNFFGCVLPPLLI------MLVIYIKIFLVAcrqLQRTELMDHSRTTLQREIHAakSLAIIVGIFA 237

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 18859185 256 LIIIVLHRF-------PAYSDYR-----KIASLLFHiIPSILNPIIYGVQSSEVRH 299
Cdd:cd15069 238 LCWLPVHILncitlfqPEFSKSKpkwamNVAILLSH-ANSVVNPIVYAYRNRDFRY 292

7tmA_S1PR2_Edg5

cd15347

sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial ...

24-298

1.29e-03

sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial differentiation gene 5 (Edg5), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).

Pssm-ID: 320469 [Multi-domain] Cd Length: 266 Bit Score: 39.80 E-value: 1.29e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  24 YPVFVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLmdiLKSPSQRYISYVECVVQAF 103
Cdd:cd15347   1 QVASIFIVILCCIIVLENLLVLIAVARNKKFHSAMFFFIGNLAFSDLLAGVAFIANIL---LSGSVTFRLTPVQWFIREG 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 104 STHTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSAlAWgiallFISILIGltlrlsrcrtfiSNPFCDNAS 183
Cdd:cd15347  78 TAFITLSASVFSLLAIAIERHVAITKVKLYGSDKNCRMVLLIGA-CW-----VISIVLG------------GLPILGWNC 139

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 184 LFKL-SCEDV-TINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSRA---LKTCSTHLSLYLIMLISGLII 258
Cdd:cd15347 140 IGNLeDCSTVlPLYSKHYILFVVTIFSIILLSIVILYVRIYCIVRSSHAEMAAPQTlalLKTVTIVLGVFIVCWLPAFII 219

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 18859185 259 IVLHRFPAYSD----YRKIASLLFHIIPSILNPIIYGVQSSEVR 298
Cdd:cd15347 220 LLLDTSCKVKScpilYKADYFFSVATLNSALNPVIYTLRSKDMR 263

7tmA_purinoceptor-like

cd14982

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...

24-299

1.65e-03

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341318 [Multi-domain] Cd Length: 283 Bit Score: 39.56 E-value: 1.65e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  24 YPVFVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPRLLMDILKSPSQRYISYVECVVQAF 103
Cdd:cd14982   1 TLFPIVYSLIFILGLLGNILALWVFLRKMKKRSPTTIYMINLALADLLFVLTLPFRIYYYLNGGWWPFGDFLCRLTGLLF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 104 STHTYGTTShtILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILIGLTLRlsrcrtfiSNPFCDNAS 183
Cdd:cd14982  81 YINMYGSIL--FLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLVASVPLLLLRST--------IAKENNSTT 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 184 LFKLSCEDVTINNLYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNS----RALKTCSTHLSLYLI-------ML 252
Cdd:cd14982 151 CFEFLSEWLASAAPIVLIALVVGFLIPLLIILVCYSLIIRALRRRSKQSQKSvrkrKALRMILIVLAVFLVcflpyhvTR 230

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 18859185 253 IsgLIIIVLHRFPAYSDYRKIASLLFHI------IPSILNPIIYGVQSSEVRH 299
Cdd:cd14982 231 I--LYLLVRLSFIADCSARNSLYKAYRItlclasLNSCLDPLIYYFLSKTFRK 281

7tmA_GPR151

cd15002

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...

33-298

1.76e-03

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320133 [Multi-domain] Cd Length: 280 Bit Score: 39.32 E-value: 1.76e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  33 FYVAIMVLNI---GIFIVITTHRSLHEPMYM---LFCNLPINDILGNSIMVPRLLMDILKSPSQryISYVECVVQAFSTH 106
Cdd:cd15002   5 LLGVICLLGFagnLMVIGILLNNARKGKPSLidsLILNLSAADLLLLLFSVPFRAAAYSKGSWP--LGWFVCKTADWFGH 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 107 TYGTTSHTILIIMAIDRYVAICNPLRYQTImTNKTVITLSALAWGIALLfisilIGLTLRLSRCRTFISNPFCDNASLFK 186
Cdd:cd15002  83 ACMAAKSFTIAVLAKACYMYVVNPTKQVTI-KQRRITAVVASIWVPACL-----LPLPQWLFRTVKQSEGVYLCILCIPP 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 187 LSCEDVTInnlYGLIYTVLLFGSSMGSIAVTYIKITAVCLVTKSKMLNSR--ALKTCSTH--LSLYLIMLISGL------ 256
Cdd:cd15002 157 LAHEFMSA---FVKLYPLFVFCLPLTFALFYFWRAYGQCQRRGTKTQNLRnqIRSRKLTHmlLSVVLAFTILWLpewvaw 233

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 18859185 257 --IIIVLHRFPA-YSDYRKIASLLFHIIPSIlNPIIYGVQSSEVR 298
Cdd:cd15002 234 lwLIHIKSSGSSpPQLFNVLAQLLAFSISSV-NPIIFLLMSEEFR 277

7tmA_DmOct-betaAR-like

cd15066

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...

108-163

1.82e-03

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.

Pssm-ID: 320194 [Multi-domain] Cd Length: 265 Bit Score: 39.28 E-value: 1.82e-03

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 18859185 108 YGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALL--FISILIGL 163
Cdd:cd15066  82 FSTASILHLCCISVDRYYAIVQPLEYPSKMTKRRVAIMLANVWISPALisFLPIFLGW 139

7tmA_5-HT1B_1D

cd15333

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...

26-154

2.11e-03

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320455 [Multi-domain] Cd Length: 265 Bit Score: 39.01 E-value: 2.11e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  26 VFVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPrllMDILKSPSQRY-ISYVECVVQAFS 104
Cdd:cd15333   7 LAVLLALITLATTLSNAFVIATIYLTRKLHTPANYLIASLAVTDLLVSILVMP---ISIVYTVTGTWtLGQVVCDIWLSS 83

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 18859185 105 THTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIAL 154
Cdd:cd15333  84 DITCCTASILHLCVIALDRYWAITDAVEYSKKRTPKRAAVMIALVWVISI 133

7tmA_Beta3_AR

cd15959

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...

110-160

2.37e-03

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.

Pssm-ID: 320625 [Multi-domain] Cd Length: 302 Bit Score: 39.12 E-value: 2.37e-03

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 18859185 110 TTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIAlLFISIL 160
Cdd:cd15959  85 TASIETLCAIAVDRYLAITNPLRYEALVTKRRARTAVCLVWAIS-AAISFL 134

7tmA_Melanopsin

cd15336

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...

35-156

2.86e-03

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320458 [Multi-domain] Cd Length: 290 Bit Score: 38.93 E-value: 2.86e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  35 VAIMVLNIGI------FIVITT---HRSLHEPMYMLFCNLPINDILGNSIMVPRLLmdiLKSPSQRYI-SYVECVVQAFS 104
Cdd:cd15336   3 VGSVILIIGItgmlgnALVIYAfcrSKKLRTPANYFIINLAVSDFLMSLTQSPIFF---VNSLHKRWIfGEKGCELYAFC 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 18859185 105 THTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNK------TVITLSALAWGIALLF 156
Cdd:cd15336  80 GALFGITSMITLLAISLDRYLVITKPLASIRWVSKKramiiiLLVWLYSLAWSLPPLF 137

7tmA_Peropsin

cd15073

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...

41-150

3.47e-03

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.

Pssm-ID: 320201 [Multi-domain] Cd Length: 280 Bit Score: 38.56 E-value: 3.47e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  41 NIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPrllMDILKSPSQRYI-SYVECVVQAFSTHTYGTTSHTILIIM 119
Cdd:cd15073  18 NGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIGYP---FSAASDLHGSWKfGYAGCQWYAFLNIFFGMASIGLLTVV 94

                        90       100       110
                ....*....|....*....|....*....|.
gi 18859185 120 AIDRYVAICNPLRYQTiMTNKTVITLSALAW 150
Cdd:cd15073  95 AVDRYLTICRPDLGRK-MTTNTYTVMILLAW 124

7tmA_Cannabinoid_R

cd15099

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled ...

41-299

4.52e-03

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.

Pssm-ID: 320227 [Multi-domain] Cd Length: 281 Bit Score: 38.28 E-value: 4.52e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  41 NIGIFIVITTHRSLH-EPMYMLFCNLPINDILGNSIMVPRLLMDIL---KSPSQRYISYVECVVQAFsthtygTTSHTIL 116
Cdd:cd15099  18 NILVLLTILSSTALRrRPSYLFIGSLALADMLASVIFTISFLDFHVfhqRDSRNLFLFKLGGVTMAF------TASVGSL 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 117 IIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLfISILIGLTLRLSRCRTFISNPFCDNASLFKLSCEDVTINN 196
Cdd:cd15099  92 LLTALDRYLCIYQPSNYKLLVTRTRAKVAILLMWCVTII-ISFLPLMGWRCKTWDSPCSRLFPYIDRHYLASWTGLQLVL 170

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 197 LYGLIYTVLLFGSSMGSIAVTYI--KITAVCLVTKSKM-LNSRALKTCSTHLSLYLIMLISGLIIIVLHRFPAYSDYRKI 273
Cdd:cd15099 171 LFLIIYAYPYILWKAHRHEANMGgpKLGRQQVKGQARMrMDIRLAKTLSLILLVLAICWLPVLAFMLVDVRVTLTNKQKR 250

                       250       260
                ....*....|....*....|....*....
gi 18859185 274 A---SLLFHIIPSILNPIIYGVQSSEVRH 299
Cdd:cd15099 251 MfafCSMLCLVNSCVNPIIYALRSRELRG 279

7tmA_alpha1B_AR

cd15326

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...

33-159

4.55e-03

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320449 [Multi-domain] Cd Length: 261 Bit Score: 37.95 E-value: 4.55e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  33 FYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPrlLMDILKSPSQRYISYVECVVQAFSTHTYGTTS 112
Cdd:cd15326  10 FILFAIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLP--FSATLEILGYWVFGRIFCDIWAAVDVLCCTAS 87

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 18859185 113 HTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLfISI 159
Cdd:cd15326  88 ILSLCAISIDRYIGVRHSLQYPTIVTRKRAILALLGVWVLSTV-ISI 133

7tmA_Ap5-HTB1-like

cd15065

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...

27-207

4.74e-03

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.

Pssm-ID: 320193 [Multi-domain] Cd Length: 300 Bit Score: 38.10 E-value: 4.74e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  27 FVFFLLFYVAImVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSI-MVPRLLMDILKspsqrYISYVECVVQAFST 105
Cdd:cd15065   4 IFLSLIIVLAI-FGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLvMTFAVVNDLLG-----YWLFGETFCNIWIS 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185 106 HTYGTTSHTILIIMAI--DRYVAICNPLRYQTIMTNKTVITLSALAWGIALL--FISILIGLTLRLSrcrtfISNPFCDN 181
Cdd:cd15065  78 FDVMCSTASILNLCAIslDRYIHIKKPLKYERWMTTRRALVVIASVWILSALisFLPIHLGWHRLSQ-----DEIKGLNH 152

                       170       180
                ....*....|....*....|....*.
gi 18859185 182 ASLFKLSCEdVTINNLYGLIYTVLLF 207
Cdd:cd15065 153 ASNPKPSCA-LDLNPTYAVVSSLISF 177

7tmA_GPR65_TDAG8

cd15365

proton-sensing G protein-coupled receptor 65, member of the class A family of ...

26-161

5.27e-03

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.

Pssm-ID: 320487 [Multi-domain] Cd Length: 277 Bit Score: 37.84 E-value: 5.27e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  26 VFVFFLLFYVAIMV-LNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVprLLMDILKSPSQRYISYVECVVQAFS 104
Cdd:cd15365   2 LFPFVYIFVIVISIpSNCISLYVSCLQIRKKNELGVYLFNLSLSDLLYIVILP--LWIDYLWNGDNWTLSGFVCIFSAFL 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 18859185 105 THTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALLFISILI 161
Cdd:cd15365  80 LYTNFYTSTALLTCIALDRYLAVVHPLKFMHLRTIRTALSVSVAIWLLEICFNAVIL 136

7tmA_motilin_R

cd15132

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...

109-155

5.68e-03

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).

Pssm-ID: 320260 [Multi-domain] Cd Length: 289 Bit Score: 37.85 E-value: 5.68e-03

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 18859185 109 GTTSHTILIIMA--IDRYVAICNPLRYQTIMTNKTVITLSALAWGIALL 155
Cdd:cd15132  82 GCTYATILHITAlsIERYLAICFPLRAKVLVTRRRVKCVIAALWAFALL 130

7tmA_Beta_AR

cd15058

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...

110-162

5.70e-03

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320186 [Multi-domain] Cd Length: 305 Bit Score: 37.82 E-value: 5.70e-03

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 18859185 110 TTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAWGIALL--FISILIG 162
Cdd:cd15058  85 TASIETLCVIAVDRYIAITRPLRYQVLLTKRRARVIVCVVWIVSALvsFVPIMNQ 139

7tmA_V2R

cd15388

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...

34-156

7.14e-03

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320510 [Multi-domain] Cd Length: 295 Bit Score: 37.45 E-value: 7.14e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  34 YVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMV-PRLLMDI---LKSPSQ--RYISYVECVVQAFSTHT 107
Cdd:cd15388  11 FACALLSNSLVLLVLWRRRKQLARMHVFMLHLCIADLVVAFFQVlPQLVWDItdrFRGPDVlcRLVKYLQVVGMFASSYM 90

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 18859185 108 ygttshtiLIIMAIDRYVAICNPL---RYQTIMTNKTVitlsALAWGIALLF 156
Cdd:cd15388  91 --------IVAMTFDRHQAICRPMvtfQKGRARWNGPV----CVAWAISLIL 130

7tmA_MC5R

cd15354

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...

30-150

7.19e-03

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320476 [Multi-domain] Cd Length: 270 Bit Score: 37.61 E-value: 7.19e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  30 FLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGN-----SIMVPRLLMDILKSPSQRYISYVECVVQAFS 104
Cdd:cd15354   7 FLTLGIISLLENILVILAIVKNKNLHSPMYFFVCSLAVADMLVSvsnawETITIYLLNNRHLVIEDAFVRHIDNVFDSLI 86

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 18859185 105 THTYgTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAW 150
Cdd:cd15354  87 CISV-VASMCSLLAIAVDRYVTIFYALRYHNIMTVRRAGIIIACIW 131

7tmA_Dop1R2-like

cd15067

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...

28-150

7.88e-03

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.

Pssm-ID: 320195 [Multi-domain] Cd Length: 262 Bit Score: 37.34 E-value: 7.88e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  28 VFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPrllMDILKSPSQRYISY--VEC-VVQAFS 104
Cdd:cd15067   4 VVLSLFCLVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMP---FSILHEMTGGYWLFgrDWCdVWHSFD 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 18859185 105 ThTYGTTSHTILIIMAIDRYVAICNPLRYQTIMTNKTVITLSALAW 150
Cdd:cd15067  81 V-LASTASILNLCVISLDRYWAITDPISYPSRMTKRRALIMIALVW 125

7tmA_GHSR

cd15131

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...

31-155

8.87e-03

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.

Pssm-ID: 320259 [Multi-domain] Cd Length: 291 Bit Score: 37.17 E-value: 8.87e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  31 LLFYVAIMVlNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVPrllmDILKSPSQRYISYVECVVQAFSTHTYGT 110
Cdd:cd15131   9 LLFVVGVTG-NLMTMLVVSKYRDMRTTTNLYLSSMAFSDLLIFLCMPL----DLYRLWQYRPWNFGDLLCKLFQFVSESC 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 18859185 111 TSHTILIIMA--IDRYVAICNPLRYQTIMTNKTVITLSALAWGIALL 155
Cdd:cd15131  84 TYSTILNITAlsVERYFAICFPLRAKVVVTKRRVKLVILVLWAVSFL 130

7tmA_NPSR

cd15197

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...

27-156

9.59e-03

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).

Pssm-ID: 320325 [Multi-domain] Cd Length: 294 Bit Score: 37.02 E-value: 9.59e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859185  27 FVFFLLFYVAIMVLNIGIFIVITTHRSLHEPMYMLFCNLPINDILGNSIMVprlLMDI-LKSPSQRYISYVECVVQAFST 105
Cdd:cd15197   4 LATLWVLFVFIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLCVGLINV---LTDIiWRITVEWRAGDFACKVIRYLQ 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 18859185 106 HTYGTTSHTILIIMAIDRYVAICNPLRYQTimTNKTVITLSALAWGIALLF 156
Cdd:cd15197  81 VVVTYASTYVLVALSIDRYDAICHPMNFSQ--SGRQARVLICVAWILSALF 129

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01