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Conserved domains on  [gi|1128611429|ref|NP_571454|]
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anosmin-1b precursor [Danio rerio]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cys_box super family cl39347
Anosmin cysteine rich domain; This is the Cys-box (cysteine-rich) domain found on the ...
 35-108 1.27e-35

Anosmin cysteine rich domain; This is the Cys-box (cysteine-rich) domain found on the N-terminal of anosmin-1 proteins. It is suggested that the Cys-box domain may resemble the cysteine-rich region of the insulin-like growth factor receptor. Family members are found in chordates.


The actual alignment was detected with superfamily member pfam17869:

Pssm-ID: 465542  Cd Length: 82  Bit Score: 128.86  E-value: 1.27e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611429  35 SARCVSRCLTLHITQITAAFRHLQNDRVLGWCENHRRCSQCLQPCKELWETRRALSPKTCE------HHECVTSAEFLRS 108
Cdd:pfam17869   3 RARCASRCLSLHITQITAAFQHFQSNGSLGWCQNHKQCAKCLEPCKESWETRKGLCRKLCEplfpkkHTECVTSCEFLKS 82
WAP smart00217
Four-disulfide core domains;
113-159 2.26e-14

Four-disulfide core domains;


:

Pssm-ID: 197580 [Multi-domain]  Cd Length: 47  Bit Score: 67.39  E-value: 2.26e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1128611429  113 KQGDCPPAQRASGFAAACVESCARDRECSGVKKCCSNGCGHTCQSPA 159
Cdd:smart00217   1 KPGSCPWPTIASCPLGNPPNKCSSDSQCPGVKKCCFNGCGKSCLTPV 47
fn3 pfam00041
Fibronectin type III domain;
285-358 2.79e-08

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 51.26  E-value: 2.79e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1128611429 285 TLHPDGTVSVLVLWETPRESDLVVHHHKVTWSPRGTPSSSQSRagrVTDGDVTQMELQGLQPNTPYTAQIQAIS 358
Cdd:pfam00041   7 TVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEI---TVPGTTTSVTLTGLKPGTEYEVRVQAVN 77
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 166-254 1.15e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 44.02  E-value: 1.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611429 166 PLKPRrDISFSEDHQGHVKVTWMSKFNVSVEPVLYVLQRRwnhgihpsEDEASAWQTVLMTMEDRS--VLKDIRPHRWYQ 243
Cdd:cd00063     1 PSPPT-NLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYR--------EKGSGDWKEVEVTPGSETsyTLTGLKPGTEYE 71

                          90
                  ....*....|.
gi 1128611429 244 FRVSAVNSQGT 254
Cdd:cd00063    72 FRVRAVNGGGE 82
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
215-495 1.58e-05

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 48.07  E-value: 1.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611429 215 DEASAWQTVLMTMEDRSVLKDIRPHRWYQFRVSAVNSQGTRgftTPSKHFFSVRDPLPPETPQNArtanqTLHPDGTVSV 294
Cdd:COG3401   178 AAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGES---APSNEVSVTTPTTPPSAPTGL-----TATADTPGSV 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611429 295 LVLWETPRESDLV---VHhhkvtwspRGTPSSSQSRagRVTDGDVTQMELQGLQPNTPYTAQIQAISYWGqnrlkssrah 371
Cdd:COG3401   250 TLSWDPVTESDATgyrVY--------RSNSGDGPFT--KVATVTTTSYTDTGLTNGTTYYYRVTAVDAAG---------- 309

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611429 372 isftTTSQNSATSSnGEFSNELPvshSSPSVLRLEAAAPhyhdnqLQVKVFWKSRvqeSQKDSSSY-ILRWYPEvcshNV 450
Cdd:COG3401   310 ----NESAPSNVVS-VTTDLTPP---AAPSGLTATAVGS------SSITLSWTAS---SDADVTGYnVYRSTSG----GG 368

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1128611429 451 TKDEKTATVQGTHYVITGLLFACKYRVAVKPV--AEQRSEVTTSVTT 495
Cdd:COG3401   369 TYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVdaAGNESAPSEEVSA 415
fn3 pfam00041
Fibronectin type III domain;
534-617 1.19e-04

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 41.25  E-value: 1.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611429 534 FQPVNGSlQALFSWQLSPESSGqtPSSGFQfswVKVSSGSSNGSLISQThiLPPDQLSLTVDALQPSSVYRVQVQVLSEA 613
Cdd:pfam00041   8 VTDVTST-SLTVSWTPPPDGNG--PITGYE---VEYRPKNSGEPWNEIT--VPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79


                  ....
gi 1128611429 614 GNGP 617
Cdd:pfam00041  80 GEGP 83
 
Name Accession Description Interval E-value
Cys_box pfam17869
Anosmin cysteine rich domain; This is the Cys-box (cysteine-rich) domain found on the ...
 35-108 1.27e-35

Anosmin cysteine rich domain; This is the Cys-box (cysteine-rich) domain found on the N-terminal of anosmin-1 proteins. It is suggested that the Cys-box domain may resemble the cysteine-rich region of the insulin-like growth factor receptor. Family members are found in chordates.


Pssm-ID: 465542  Cd Length: 82  Bit Score: 128.86  E-value: 1.27e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611429  35 SARCVSRCLTLHITQITAAFRHLQNDRVLGWCENHRRCSQCLQPCKELWETRRALSPKTCE------HHECVTSAEFLRS 108
Cdd:pfam17869   3 RARCASRCLSLHITQITAAFQHFQSNGSLGWCQNHKQCAKCLEPCKESWETRKGLCRKLCEplfpkkHTECVTSCEFLKS 82
WAP smart00217
Four-disulfide core domains;
113-159 2.26e-14

Four-disulfide core domains;


Pssm-ID: 197580 [Multi-domain]  Cd Length: 47  Bit Score: 67.39  E-value: 2.26e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1128611429  113 KQGDCPPAQRASGFAAACVESCARDRECSGVKKCCSNGCGHTCQSPA 159
Cdd:smart00217   1 KPGSCPWPTIASCPLGNPPNKCSSDSQCPGVKKCCFNGCGKSCLTPV 47
WAP cd00199
whey acidic protein-type four-disulfide core domains. Members of the family include whey ...
 111-158 1.17e-13

whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of proteins containing 8 characteristically-spaced cysteine residuesforming disulphide bonds, have been termed '4-disulphide core' proteins. Protease inhibition occurs by insertion of the inhibitory loop into the active site pocket and interference with the catalytic residues of the protease.


Pssm-ID: 238120 [Multi-domain]  Cd Length: 60  Bit Score: 65.93  E-value: 1.17e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1128611429 111 VQKQGDCPPAQRASgfAAACVESCARDRECSGVKKCCSNGCGHTCQSP 158
Cdd:cd00199    14 VEKPGRCPMVNPPS--LGIPPNRCSSDSDCPGDKKCCENGCGKSCLTP 59
WAP pfam00095
WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or ...
 113-158 1.45e-11

WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or elastase-specific inhibitors.


Pssm-ID: 459672 [Multi-domain]  Cd Length: 42  Bit Score: 59.36  E-value: 1.45e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1128611429 113 KQGDCPPaqraSGFAAACVESCARDRECSGVKKCCSNGCGHTCQSP 158
Cdd:pfam00095   1 KPGCCPR----LGARGCCRSCCSSDDDCPGRQKCCSNGCGSVCVPP 42
fn3 pfam00041
Fibronectin type III domain;
285-358 2.79e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 51.26  E-value: 2.79e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1128611429 285 TLHPDGTVSVLVLWETPRESDLVVHHHKVTWSPRGTPSSSQSRagrVTDGDVTQMELQGLQPNTPYTAQIQAIS 358
Cdd:pfam00041   7 TVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEI---TVPGTTTSVTLTGLKPGTEYEVRVQAVN 77
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 166-254 1.15e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 44.02  E-value: 1.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611429 166 PLKPRrDISFSEDHQGHVKVTWMSKFNVSVEPVLYVLQRRwnhgihpsEDEASAWQTVLMTMEDRS--VLKDIRPHRWYQ 243
Cdd:cd00063     1 PSPPT-NLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYR--------EKGSGDWKEVEVTPGSETsyTLTGLKPGTEYE 71

                          90
                  ....*....|.
gi 1128611429 244 FRVSAVNSQGT 254
Cdd:cd00063    72 FRVRAVNGGGE 82
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
215-495 1.58e-05

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 48.07  E-value: 1.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611429 215 DEASAWQTVLMTMEDRSVLKDIRPHRWYQFRVSAVNSQGTRgftTPSKHFFSVRDPLPPETPQNArtanqTLHPDGTVSV 294
Cdd:COG3401   178 AAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGES---APSNEVSVTTPTTPPSAPTGL-----TATADTPGSV 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611429 295 LVLWETPRESDLV---VHhhkvtwspRGTPSSSQSRagRVTDGDVTQMELQGLQPNTPYTAQIQAISYWGqnrlkssrah 371
Cdd:COG3401   250 TLSWDPVTESDATgyrVY--------RSNSGDGPFT--KVATVTTTSYTDTGLTNGTTYYYRVTAVDAAG---------- 309

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611429 372 isftTTSQNSATSSnGEFSNELPvshSSPSVLRLEAAAPhyhdnqLQVKVFWKSRvqeSQKDSSSY-ILRWYPEvcshNV 450
Cdd:COG3401   310 ----NESAPSNVVS-VTTDLTPP---AAPSGLTATAVGS------SSITLSWTAS---SDADVTGYnVYRSTSG----GG 368

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1128611429 451 TKDEKTATVQGTHYVITGLLFACKYRVAVKPV--AEQRSEVTTSVTT 495
Cdd:COG3401   369 TYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVdaAGNESAPSEEVSA 415
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 270-361 1.86e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 43.64  E-value: 1.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611429 270 PLPPETPqnartanqTLHPDGTVSVLVLWETPRESDLVVHHHKVTWSPRGTPSSSQSRagrVTDGDVTQMELQGLQPNTP 349
Cdd:cd00063     1 PSPPTNL--------RVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVE---VTPGSETSYTLTGLKPGTE 69

                          90
                  ....*....|..
gi 1128611429 350 YTAQIQAISYWG 361
Cdd:cd00063    70 YEFRVRAVNGGG 81
fn3 pfam00041
Fibronectin type III domain;
534-617 1.19e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 41.25  E-value: 1.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611429 534 FQPVNGSlQALFSWQLSPESSGqtPSSGFQfswVKVSSGSSNGSLISQThiLPPDQLSLTVDALQPSSVYRVQVQVLSEA 613
Cdd:pfam00041   8 VTDVTST-SLTVSWTPPPDGNG--PITGYE---VEYRPKNSGEPWNEIT--VPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79


                  ....
gi 1128611429 614 GNGP 617
Cdd:pfam00041  80 GEGP 83
fn3 pfam00041
Fibronectin type III domain;
169-258 1.57e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 40.86  E-value: 1.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611429 169 PRRDISFSEDHQGHVKVTWMSKFNVSVEPVLYVLQRRwnhgihpSEDEASAWQTVLMTMEDRSV-LKDIRPHRWYQFRVS 247
Cdd:pfam00041   2 APSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYR-------PKNSGEPWNEITVPGTTTSVtLTGLKPGTEYEVRVQ 74

                          90
                  ....*....|.
gi 1128611429 248 AVNSQGTRGFT 258
Cdd:pfam00041  75 AVNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 166-253 2.66e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 39.91  E-value: 2.66e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611429  166 PLKPRrDISFSEDHQGHVKVTWM-SKFNVSVEPVL-YVLQRRwnhgihpseDEASAWQTVLMTMEDRSV-LKDIRPHRWY 242
Cdd:smart00060   1 PSPPS-NLRVTDVTSTSVTLSWEpPPDDGITGYIVgYRVEYR---------EEGSEWKEVNVTPSSTSYtLTGLKPGTEY 70

                           90
                   ....*....|.
gi 1128611429  243 QFRVSAVNSQG 253
Cdd:smart00060  71 EFRVRAVNGAG 81
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 270-362 1.30e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 37.98  E-value: 1.30e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611429  270 PLPPETPqnartanqTLHPDGTVSVLVLWETPRESdlVVHHHKVTWSPRGTPSSSQSRAGRVTDGDvTQMELQGLQPNTP 349
Cdd:smart00060   1 PSPPSNL--------RVTDVTSTSVTLSWEPPPDD--GITGYIVGYRVEYREEGSEWKEVNVTPSS-TSYTLTGLKPGTE 69

                           90
                   ....*....|...
gi 1128611429  350 YTAQIQAISYWGQ 362
Cdd:smart00060  70 YEFRVRAVNGAGE 82
 
Name Accession Description Interval E-value
Cys_box pfam17869
Anosmin cysteine rich domain; This is the Cys-box (cysteine-rich) domain found on the ...
 35-108 1.27e-35

Anosmin cysteine rich domain; This is the Cys-box (cysteine-rich) domain found on the N-terminal of anosmin-1 proteins. It is suggested that the Cys-box domain may resemble the cysteine-rich region of the insulin-like growth factor receptor. Family members are found in chordates.


Pssm-ID: 465542  Cd Length: 82  Bit Score: 128.86  E-value: 1.27e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611429  35 SARCVSRCLTLHITQITAAFRHLQNDRVLGWCENHRRCSQCLQPCKELWETRRALSPKTCE------HHECVTSAEFLRS 108
Cdd:pfam17869   3 RARCASRCLSLHITQITAAFQHFQSNGSLGWCQNHKQCAKCLEPCKESWETRKGLCRKLCEplfpkkHTECVTSCEFLKS 82
WAP smart00217
Four-disulfide core domains;
113-159 2.26e-14

Four-disulfide core domains;


Pssm-ID: 197580 [Multi-domain]  Cd Length: 47  Bit Score: 67.39  E-value: 2.26e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1128611429  113 KQGDCPPAQRASGFAAACVESCARDRECSGVKKCCSNGCGHTCQSPA 159
Cdd:smart00217   1 KPGSCPWPTIASCPLGNPPNKCSSDSQCPGVKKCCFNGCGKSCLTPV 47
WAP cd00199
whey acidic protein-type four-disulfide core domains. Members of the family include whey ...
 111-158 1.17e-13

whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of proteins containing 8 characteristically-spaced cysteine residuesforming disulphide bonds, have been termed '4-disulphide core' proteins. Protease inhibition occurs by insertion of the inhibitory loop into the active site pocket and interference with the catalytic residues of the protease.


Pssm-ID: 238120 [Multi-domain]  Cd Length: 60  Bit Score: 65.93  E-value: 1.17e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1128611429 111 VQKQGDCPPAQRASgfAAACVESCARDRECSGVKKCCSNGCGHTCQSP 158
Cdd:cd00199    14 VEKPGRCPMVNPPS--LGIPPNRCSSDSDCPGDKKCCENGCGKSCLTP 59
WAP pfam00095
WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or ...
 113-158 1.45e-11

WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or elastase-specific inhibitors.


Pssm-ID: 459672 [Multi-domain]  Cd Length: 42  Bit Score: 59.36  E-value: 1.45e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1128611429 113 KQGDCPPaqraSGFAAACVESCARDRECSGVKKCCSNGCGHTCQSP 158
Cdd:pfam00095   1 KPGCCPR----LGARGCCRSCCSSDDDCPGRQKCCSNGCGSVCVPP 42
fn3 pfam00041
Fibronectin type III domain;
285-358 2.79e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 51.26  E-value: 2.79e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1128611429 285 TLHPDGTVSVLVLWETPRESDLVVHHHKVTWSPRGTPSSSQSRagrVTDGDVTQMELQGLQPNTPYTAQIQAIS 358
Cdd:pfam00041   7 TVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEI---TVPGTTTSVTLTGLKPGTEYEVRVQAVN 77
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 166-254 1.15e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 44.02  E-value: 1.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611429 166 PLKPRrDISFSEDHQGHVKVTWMSKFNVSVEPVLYVLQRRwnhgihpsEDEASAWQTVLMTMEDRS--VLKDIRPHRWYQ 243
Cdd:cd00063     1 PSPPT-NLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYR--------EKGSGDWKEVEVTPGSETsyTLTGLKPGTEYE 71

                          90
                  ....*....|.
gi 1128611429 244 FRVSAVNSQGT 254
Cdd:cd00063    72 FRVRAVNGGGE 82
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
215-495 1.58e-05

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 48.07  E-value: 1.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611429 215 DEASAWQTVLMTMEDRSVLKDIRPHRWYQFRVSAVNSQGTRgftTPSKHFFSVRDPLPPETPQNArtanqTLHPDGTVSV 294
Cdd:COG3401   178 AAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGES---APSNEVSVTTPTTPPSAPTGL-----TATADTPGSV 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611429 295 LVLWETPRESDLV---VHhhkvtwspRGTPSSSQSRagRVTDGDVTQMELQGLQPNTPYTAQIQAISYWGqnrlkssrah 371
Cdd:COG3401   250 TLSWDPVTESDATgyrVY--------RSNSGDGPFT--KVATVTTTSYTDTGLTNGTTYYYRVTAVDAAG---------- 309

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611429 372 isftTTSQNSATSSnGEFSNELPvshSSPSVLRLEAAAPhyhdnqLQVKVFWKSRvqeSQKDSSSY-ILRWYPEvcshNV 450
Cdd:COG3401   310 ----NESAPSNVVS-VTTDLTPP---AAPSGLTATAVGS------SSITLSWTAS---SDADVTGYnVYRSTSG----GG 368

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1128611429 451 TKDEKTATVQGTHYVITGLLFACKYRVAVKPV--AEQRSEVTTSVTT 495
Cdd:COG3401   369 TYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVdaAGNESAPSEEVSA 415
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 270-361 1.86e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 43.64  E-value: 1.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611429 270 PLPPETPqnartanqTLHPDGTVSVLVLWETPRESDLVVHHHKVTWSPRGTPSSSQSRagrVTDGDVTQMELQGLQPNTP 349
Cdd:cd00063     1 PSPPTNL--------RVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVE---VTPGSETSYTLTGLKPGTE 69

                          90
                  ....*....|..
gi 1128611429 350 YTAQIQAISYWG 361
Cdd:cd00063    70 YEFRVRAVNGGG 81
fn3 pfam00041
Fibronectin type III domain;
534-617 1.19e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 41.25  E-value: 1.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611429 534 FQPVNGSlQALFSWQLSPESSGqtPSSGFQfswVKVSSGSSNGSLISQThiLPPDQLSLTVDALQPSSVYRVQVQVLSEA 613
Cdd:pfam00041   8 VTDVTST-SLTVSWTPPPDGNG--PITGYE---VEYRPKNSGEPWNEIT--VPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79


                  ....
gi 1128611429 614 GNGP 617
Cdd:pfam00041  80 GEGP 83
fn3 pfam00041
Fibronectin type III domain;
169-258 1.57e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 40.86  E-value: 1.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611429 169 PRRDISFSEDHQGHVKVTWMSKFNVSVEPVLYVLQRRwnhgihpSEDEASAWQTVLMTMEDRSV-LKDIRPHRWYQFRVS 247
Cdd:pfam00041   2 APSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYR-------PKNSGEPWNEITVPGTTTSVtLTGLKPGTEYEVRVQ 74

                          90
                  ....*....|.
gi 1128611429 248 AVNSQGTRGFT 258
Cdd:pfam00041  75 AVNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 166-253 2.66e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 39.91  E-value: 2.66e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611429  166 PLKPRrDISFSEDHQGHVKVTWM-SKFNVSVEPVL-YVLQRRwnhgihpseDEASAWQTVLMTMEDRSV-LKDIRPHRWY 242
Cdd:smart00060   1 PSPPS-NLRVTDVTSTSVTLSWEpPPDDGITGYIVgYRVEYR---------EEGSEWKEVNVTPSSTSYtLTGLKPGTEY 70

                           90
                   ....*....|.
gi 1128611429  243 QFRVSAVNSQG 253
Cdd:smart00060  71 EFRVRAVNGAG 81
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 270-362 1.30e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 37.98  E-value: 1.30e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128611429  270 PLPPETPqnartanqTLHPDGTVSVLVLWETPRESdlVVHHHKVTWSPRGTPSSSQSRAGRVTDGDvTQMELQGLQPNTP 349
Cdd:smart00060   1 PSPPSNL--------RVTDVTSTSVTLSWEPPPDD--GITGYIVGYRVEYREEGSEWKEVNVTPSS-TSYTLTGLKPGTE 69

                           90
                   ....*....|...
gi 1128611429  350 YTAQIQAISYWGQ 362
Cdd:smart00060  70 YEFRVRAVNGAGE 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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