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Conserved domains on  [gi|47271370|ref|NP_571772|]
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decorin precursor [Danio rerio]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 12183199)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
95-316 1.40e-27

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 112.33  E-value: 1.40e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271370  95 TTLLDLQNNKITEIKENDFKGLKGLQTLILVNNKitiihakAFSSLINLERLYLSKNLLKEVPANIP--KSLQELRIHEN 172
Cdd:COG4886  74 LLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEELAnlTNLKELDLSNN 146

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271370 173 QINKIKkSSFAGMANVIVMELGSNPLSSsgVDNgAFADLKRVSYIRIADTNLTSIPKGL--PSSLFELHLDGNKITKVTa 250
Cdd:COG4886 147 QLTDLP-EPLGNLTNLKSLDLSNNQLTD--LPE-ELGNLTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTDLP- 221

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 47271370 251 DSLKGLKNLSKLGLSHNEISVVEngSLANVPHLRELHLENNALTAVPAgLADHKYIQVIYLHSNKI 316
Cdd:COG4886 222 EPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQL 284
LRRNT smart00013
Leucine rich repeat N-terminal domain;
66-97 2.10e-09

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 52.32  E-value: 2.10e-09
                           10        20        30
                   ....*....|....*....|....*....|..
gi 47271370     66 CPFRCQCHLRVAQCSDLGLKTVPEKIPLDTTL 97
Cdd:smart00013   2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
95-316 1.40e-27

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 112.33  E-value: 1.40e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271370  95 TTLLDLQNNKITEIKENDFKGLKGLQTLILVNNKitiihakAFSSLINLERLYLSKNLLKEVPANIP--KSLQELRIHEN 172
Cdd:COG4886  74 LLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEELAnlTNLKELDLSNN 146

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271370 173 QINKIKkSSFAGMANVIVMELGSNPLSSsgVDNgAFADLKRVSYIRIADTNLTSIPKGL--PSSLFELHLDGNKITKVTa 250
Cdd:COG4886 147 QLTDLP-EPLGNLTNLKSLDLSNNQLTD--LPE-ELGNLTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTDLP- 221

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 47271370 251 DSLKGLKNLSKLGLSHNEISVVEngSLANVPHLRELHLENNALTAVPAgLADHKYIQVIYLHSNKI 316
Cdd:COG4886 222 EPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQL 284
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
82-310 1.85e-15

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 77.81  E-value: 1.85e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271370   82 LGLKTVPEKIPLDTTLLDLQNNKITEIKENdfkglkglqtlilvnnkitiIHAkafssliNLERLYLSKNLLKEVPANIP 161
Cdd:PRK15370 188 LGLTTIPACIPEQITTLILDNNELKSLPEN--------------------LQG-------NIKTLYANSNQLTSIPATLP 240

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271370  162 KSLQELRIHENQINKIKKSSFAGMANVIVMELGSNPLSSSGVDNgafadlkrVSYIRIADTNLTSIPKGLPSSLFELHLD 241
Cdd:PRK15370 241 DTIQEMELSINRITELPERLPSALQSLDLFHNKISCLPENLPEE--------LRYLSVYDNSIRTLPAHLPSGITHLNVQ 312

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271370  242 GNKITKVTADSLKGLK------------------NLSKLGLSHNEISVVENgSLAnvPHLRELHLENNALTAVPAGL-AD 302
Cdd:PRK15370 313 SNSLTALPETLPPGLKtleagenaltslpaslppELQVLDVSKNQITVLPE-TLP--PTITTLDVSRNALTNLPENLpAA 389


                 ....*...
gi 47271370  303 HKYIQVIY 310
Cdd:PRK15370 390 LQIMQASR 397
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 146-293 4.62e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 67.89  E-value: 4.62e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271370 146 LYLSKNLLKEVPA-NIPKSLQELRIHENQINKIKKSSFAgmanvivmelgsnplsssgvdngafadlkrvsyiriadTNL 224
Cdd:cd21340   7 LYLNDKNITKIDNlSLCKNLKVLYLYDNKITKIENLEFL--------------------------------------TNL 48

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 47271370 225 TSipkglpsslfeLHLDGNKITKVtaDSLKGLKNLSKLGLSHNEISVVENgsLANVPHLRELHLENNAL 293
Cdd:cd21340  49 TH-----------LYLQNNQIEKI--ENLENLVNLKKLYLGGNRISVVEG--LENLTNLEELHIENQRL 102
LRR_8 pfam13855
Leucine rich repeat;
233-293 1.30e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.46  E-value: 1.30e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 47271370   233 SSLFELHLDGNKITKVTADSLKGLKNLSKLGLSHNEISVVENGSLANVPHLRELHLENNAL 293
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRNT smart00013
Leucine rich repeat N-terminal domain;
66-97 2.10e-09

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 52.32  E-value: 2.10e-09
                           10        20        30
                   ....*....|....*....|....*....|..
gi 47271370     66 CPFRCQCHLRVAQCSDLGLKTVPEKIPLDTTL 97
Cdd:smart00013   2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 66-92 1.59e-07

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 46.85  E-value: 1.59e-07
                          10        20
                  ....*....|....*....|....*..
gi 47271370    66 CPFRCQCHLRVAQCSDLGLKTVPEKIP 92
Cdd:pfam01462   2 CPVPCHCSATVVNCSDRGLTAVPRDLP 28
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
95-316 1.40e-27

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 112.33  E-value: 1.40e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271370  95 TTLLDLQNNKITEIKENDFKGLKGLQTLILVNNKitiihakAFSSLINLERLYLSKNLLKEVPANIP--KSLQELRIHEN 172
Cdd:COG4886  74 LLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEELAnlTNLKELDLSNN 146

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271370 173 QINKIKkSSFAGMANVIVMELGSNPLSSsgVDNgAFADLKRVSYIRIADTNLTSIPKGL--PSSLFELHLDGNKITKVTa 250
Cdd:COG4886 147 QLTDLP-EPLGNLTNLKSLDLSNNQLTD--LPE-ELGNLTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTDLP- 221

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 47271370 251 DSLKGLKNLSKLGLSHNEISVVEngSLANVPHLRELHLENNALTAVPAgLADHKYIQVIYLHSNKI 316
Cdd:COG4886 222 EPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
96-324 9.44e-25

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 104.25  E-value: 9.44e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271370  96 TLLDLQNNKITEIkENDFKGLKGLQTLILVNNKITIIHAkAFSSLINLERLYLSKNLLKEVPANIP--KSLQELRIHENQ 173
Cdd:COG4886 116 ESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEELGnlTNLKELDLSNNQ 193

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271370 174 INKIKKSsFAGMANVIVMELGSNPLSSSGVDngaFADLKRVSYIRIADTNLTSIP--KGLPSsLFELHLDGNKITKVtaD 251
Cdd:COG4886 194 ITDLPEP-LGNLTNLEELDLSGNQLTDLPEP---LANLTNLETLDLSNNQLTDLPelGNLTN-LEELDLSNNQLTDL--P 266

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 47271370 252 SLKGLKNLSKLGLSHNEISVVENGSLANVPHLRELHLENNALTAVPAGLADHKYIQVIYLHSNKIAAVGTEDF 324
Cdd:COG4886 267 PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTT 339
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
100-322 7.91e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.13  E-value: 7.91e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271370 100 LQNNKITEIKENDFKGLKGLQTLILVNNKITIIHAKAFSSLINLERLYLSKNLLKEVPANIPKSLQELRIHENQINKIKK 179
Cdd:COG4886   1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271370 180 SSFAGMANVIVMELGSNPLSSSGVDNGAFADLKRVSYIRIADTNLTSIPKGLPS--SLFELHLDGNKITKVTaDSLKGLK 257
Cdd:COG4886  81 LLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLP-EPLGNLT 159

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 47271370 258 NLSKLGLSHNEISVVENgSLANVPHLRELHLENNALTAVPAGLADHKYIQVIYLHSNKIAAVGTE 322
Cdd:COG4886 160 NLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEP 223
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
82-310 1.85e-15

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 77.81  E-value: 1.85e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271370   82 LGLKTVPEKIPLDTTLLDLQNNKITEIKENdfkglkglqtlilvnnkitiIHAkafssliNLERLYLSKNLLKEVPANIP 161
Cdd:PRK15370 188 LGLTTIPACIPEQITTLILDNNELKSLPEN--------------------LQG-------NIKTLYANSNQLTSIPATLP 240

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271370  162 KSLQELRIHENQINKIKKSSFAGMANVIVMELGSNPLSSSGVDNgafadlkrVSYIRIADTNLTSIPKGLPSSLFELHLD 241
Cdd:PRK15370 241 DTIQEMELSINRITELPERLPSALQSLDLFHNKISCLPENLPEE--------LRYLSVYDNSIRTLPAHLPSGITHLNVQ 312

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271370  242 GNKITKVTADSLKGLK------------------NLSKLGLSHNEISVVENgSLAnvPHLRELHLENNALTAVPAGL-AD 302
Cdd:PRK15370 313 SNSLTALPETLPPGLKtleagenaltslpaslppELQVLDVSKNQITVLPE-TLP--PTITTLDVSRNALTNLPENLpAA 389


                 ....*...
gi 47271370  303 HKYIQVIY 310
Cdd:PRK15370 390 LQIMQASR 397
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 146-293 4.62e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 67.89  E-value: 4.62e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271370 146 LYLSKNLLKEVPA-NIPKSLQELRIHENQINKIKKSSFAgmanvivmelgsnplsssgvdngafadlkrvsyiriadTNL 224
Cdd:cd21340   7 LYLNDKNITKIDNlSLCKNLKVLYLYDNKITKIENLEFL--------------------------------------TNL 48

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 47271370 225 TSipkglpsslfeLHLDGNKITKVtaDSLKGLKNLSKLGLSHNEISVVENgsLANVPHLRELHLENNAL 293
Cdd:cd21340  49 TH-----------LYLQNNQIEKI--ENLENLVNLKKLYLGGNRISVVEG--LENLTNLEELHIENQRL 102
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 96-297 5.33e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 67.50  E-value: 5.33e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271370  96 TLLDLQNNKITEIkeNDFKGLKGLQTLILVNNKITIIhaKAFSSLINLERLYLSKNLLKEvpanIP-----KSLQELRIH 170
Cdd:cd21340   5 THLYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEK----IEnlenlVNLKKLYLG 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271370 171 ENQINKIKkssfaGMANVIVM-ELgsnplsssgvdngafadlkRVSYIRIA-DTNLTSIP---KGLPSSLFELHLDGNKI 245
Cdd:cd21340  77 GNRISVVE-----GLENLTNLeEL-------------------HIENQRLPpGEKLTFDPrslAALSNSLRVLNISGNNI 132

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 47271370 246 TkvTADSLKGLKNLSKLGLSHNEISVVEN--GSLANVPHLRELHLENNALTAVP 297
Cdd:cd21340 133 D--SLEPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKP 184
LRR_8 pfam13855
Leucine rich repeat;
233-293 1.30e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.46  E-value: 1.30e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 47271370   233 SSLFELHLDGNKITKVTADSLKGLKNLSKLGLSHNEISVVENGSLANVPHLRELHLENNAL 293
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
96-153 4.71e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.53  E-value: 4.71e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 47271370    96 TLLDLQNNKITEIKENDFKGLKGLQTLILVNNKITIIHAKAFSSLINLERLYLSKNLL 153
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
84-284 3.09e-10

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 61.64  E-value: 3.09e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271370   84 LKTVPEKIPLDTTLLDLQNNKITEIKEndfKGLKGLQTLILVNNKITIIHAKAFSSLinlERLYLSKNLLKEVPANIPKS 163
Cdd:PRK15370 232 LTSIPATLPDTIQEMELSINRITELPE---RLPSALQSLDLFHNKISCLPENLPEEL---RYLSVYDNSIRTLPAHLPSG 305

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271370  164 LQELRIHENQINKIKKSSFAGMAnviVMELGSNPLSSsgVDNGAFADLKRVSyirIADTNLTSIPKGLPSSLFELHLDGN 243
Cdd:PRK15370 306 ITHLNVQSNSLTALPETLPPGLK---TLEAGENALTS--LPASLPPELQVLD---VSKNQITVLPETLPPTITTLDVSRN 377

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 47271370  244 KITKVTADSLKGLKNLSKlglSHNEISVVENgslaNVPHLR 284
Cdd:PRK15370 378 ALTNLPENLPAALQIMQA---SRNNLVRLPE----SLPHFR 411
LRRNT smart00013
Leucine rich repeat N-terminal domain;
66-97 2.10e-09

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 52.32  E-value: 2.10e-09
                           10        20        30
                   ....*....|....*....|....*....|..
gi 47271370     66 CPFRCQCHLRVAQCSDLGLKTVPEKIPLDTTL 97
Cdd:smart00013   2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 98-317 6.21e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 57.94  E-value: 6.21e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271370   98 LDLQNNKITEIKENDFkgLKGLQTLILVNNKITIIHAKAFSSLINLERLYLSKN-LLKEVPANIPK--SLQELRIHENQI 174
Cdd:PLN00113 123 LNLSNNNFTGSIPRGS--IPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNvLVGKIPNSLTNltSLEFLTLASNQL 200

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271370  175 NKIKKSSFAGMANVIVMELGSNPLSssGVDNGAFADLKRVSYIRIADTNLT-SIPKGLP--SSLFELHLDGNKITKVTAD 251
Cdd:PLN00113 201 VGQIPRELGQMKSLKWIYLGYNNLS--GEIPYEIGGLTSLNHLDLVYNNLTgPIPSSLGnlKNLQYLFLYQNKLSGPIPP 278

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 47271370  252 SLKGLKNLSKLGLSHNEISVVENGSLANVPHLRELHLENNALTA-VPAGLADHKYIQVIYLHSNKIA 317
Cdd:PLN00113 279 SIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGkIPVALTSLPRLQVLQLWSNKFS 345
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
74-205 1.08e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 57.01  E-value: 1.08e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271370   74 LRVAQCSDLGLKTVPEKIPLDTTLLDLQNNKITEIKENDFKGLK------------------GLQTLILVNNKITIIHAK 135
Cdd:PRK15370 285 LRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPETLPPGLKtleagenaltslpaslppELQVLDVSKNQITVLPET 364

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 47271370  136 AFSSLinlERLYLSKNLLKEVPANIPKSLQELRIHENQINKIKKS--SFAG---MANVIVMElgSNPLSSSGVDN 205
Cdd:PRK15370 365 LPPTI---TTLDVSRNALTNLPENLPAALQIMQASRNNLVRLPESlpHFRGegpQPTRIIVE--YNPFSERTIQN 434
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 78-295 3.19e-08

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 55.18  E-value: 3.19e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271370  78 QCSDLGLKTVPEKIPLDTTL--LDLQNNKITEIKENDF----KGLKGLQTLILVNNKIT----IIHAKAFSSLINLERLY 147
Cdd:COG5238 191 QIGDEGIEELAEALTQNTTVttLWLKRNPIGDEGAEILaealKGNKSLTTLDLSNNQIGdegvIALAEALKNNTTVETLY 270

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271370 148 LSKN---------LLKEVPANipKSLQELRIHENQIN----KIKKSSFAGMANVIVMELGSNPLSSSGVdNGAFADLKrv 214
Cdd:COG5238 271 LSGNqigaegaiaLAKALQGN--TTLTSLDLSVNRIGdegaIALAEGLQGNKTLHTLNLAYNGIGAQGA-IALAKALQ-- 345

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271370 215 syiriADTNLTSipkglpsslfeLHLDGNKIT----KVTADSLKGLKNLSKLGLSHNEISVVENGSLA---NVPHLRELH 287
Cdd:COG5238 346 -----ENTTLHS-----------LDLSDNQIGdegaIALAKYLEGNTTLRELNLGKNNIGKQGAEALIdalQTNRLHTLI 409


                ....*...
gi 47271370 288 LENNALTA 295
Cdd:COG5238 410 LDGNLIGA 417
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 66-92 1.59e-07

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 46.85  E-value: 1.59e-07
                          10        20
                  ....*....|....*....|....*..
gi 47271370    66 CPFRCQCHLRVAQCSDLGLKTVPEKIP 92
Cdd:pfam01462   2 CPVPCHCSATVVNCSDRGLTAVPRDLP 28
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
142-347 2.06e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 52.78  E-value: 2.06e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271370  142 NLERLYLSKNLLKEVPANIPKSLQELRIHENQINKIKKSSfagMANVIVMELGSNplsssgvdngafadlkrvsyiriad 221
Cdd:PRK15370 179 NKTELRLKILGLTTIPACIPEQITTLILDNNELKSLPENL---QGNIKTLYANSN------------------------- 230

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271370  222 tNLTSIPKGLPSSLFELHLDGNKITKVTADSLKGLKNLSklgLSHNEISVVENgslaNVPH-LRELHLENNALTAVPAGL 300
Cdd:PRK15370 231 -QLTSIPATLPDTIQEMELSINRITELPERLPSALQSLD---LFHNKISCLPE----NLPEeLRYLSVYDNSIRTLPAHL 302

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 47271370  301 ADHkyIQVIYLHSNKIAAVgtEDFCPPGYNTKKAMYSGISLFSNPVP 347
Cdd:PRK15370 303 PSG--ITHLNVQSNSLTAL--PETLPPGLKTLEAGENALTSLPASLP 345
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
76-317 2.51e-07

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 52.47  E-value: 2.51e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271370   76 VAQCSDLGLKTVPEKIPLDTTLLDLQNNKIT------------EIKENDFKGLK----GLQTLILVNNKITiiHAKAFSS 139
Cdd:PRK15387 205 VLNVGESGLTTLPDCLPAHITTLVIPDNNLTslpalppelrtlEVSGNQLTSLPvlppGLLELSIFSNPLT--HLPALPS 282

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271370  140 liNLERLYLSKNLLKEVPAnIPKSLQELRIHENQInkikkSSFAGMANVIVM------ELGSNPLSSSGVDNGAFADLKR 213
Cdd:PRK15387 283 --GLCKLWIFGNQLTSLPV-LPPGLQELSVSDNQL-----ASLPALPSELCKlwaynnQLTSLPTLPSGLQELSVSDNQL 354

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271370  214 VSYIRIA---------DTNLTSIPkGLPSSLFELHLDGNKITkvtadSLKGLKN-LSKLGLSHNEISvvengSLANVPH- 282
Cdd:PRK15387 355 ASLPTLPselyklwayNNRLTSLP-ALPSGLKELIVSGNRLT-----SLPVLPSeLKELMVSGNRLT-----SLPMLPSg 423

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 47271370  283 LRELHLENNALTAVPAGLADHKYIQVIYLHSNKIA 317
Cdd:PRK15387 424 LLSLSVYRNQLTRLPESLIHLSSETTVNLEGNPLS 458
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 96-300 3.44e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 52.16  E-value: 3.44e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271370   96 TLLDLQNNKIT-EIKE------NDFKglkglqtLILVNNKITIIHAKAFSSLINLERLYLSKNLLK-EVPANIPKsLQE- 166
Cdd:PLN00113 359 TVLDLSTNNLTgEIPEglcssgNLFK-------LILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSgELPSEFTK-LPLv 430

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271370  167 --LRIHENQINKIKKSSFAGMANVIVMELGSNPLS-----SSGVDNGAFADLKRvsyiriadtNLTS--IPKGLP--SSL 235
Cdd:PLN00113 431 yfLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFgglpdSFGSKRLENLDLSR---------NQFSgaVPRKLGslSEL 501

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 47271370  236 FELHLDGNKITKVTADSLKGLKNLSKLGLSHNEISVVENGSLANVPHLRELHLENNALTA-VPAGL 300
Cdd:PLN00113 502 MQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGeIPKNL 567
LRR_8 pfam13855
Leucine rich repeat;
118-174 4.13e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.75  E-value: 4.13e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271370   118 GLQTLILVNNKITIIHAKAFSSLINLERLYLSKNLLKEVPANI---PKSLQELRIHENQI 174
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAfsgLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 238-319 6.60e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.78  E-value: 6.60e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271370 238 LHLDGNKITKVtaDSLKGLKNLSKLGLSHNEISVVENgsLANVPHLRELHLENNALTAVPaGLADHKYIQVIYLHSNKIA 317
Cdd:cd21340   7 LYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNRIS 81


                ..
gi 47271370 318 AV 319
Cdd:cd21340  82 VV 83
LRR_8 pfam13855
Leucine rich repeat;
258-316 2.21e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 2.21e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271370   258 NLSKLGLSHNEISVVENGSLANVPHLRELHLENNALTAVPAGLADH-KYIQVIYLHSNKI 316
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGlPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
163-224 2.61e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 2.61e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 47271370   163 SLQELRIHENQINKIKKSSFAGMANVIVMELGSNPLSSsgVDNGAFADLKRVSYIRIADTNL 224
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 87-294 8.20e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.84  E-value: 8.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271370   87 VPEKIPLDTTL--LDLQNNKITEIKENDFKGLKGLQTLILVNNKITIIHAKAFSSLINLERLYLSKNLLK-EVPANIP-- 161
Cdd:PLN00113 228 IPYEIGGLTSLnhLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSgEIPELVIql 307

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271370  162 KSLQELRIHENQINKIKKSSFAGMANVIVMELGSNPLSSsgvdnGAFADLKRVSYIRIAD---TNLTS-IPKGLPSS--L 235
Cdd:PLN00113 308 QNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSG-----EIPKNLGKHNNLTVLDlstNNLTGeIPEGLCSSgnL 382

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 47271370  236 FELHLDGNKITKVTADSLKGLKNLSKLGLSHNEISVVENGSLANVPHLRELHLENNALT 294
Cdd:PLN00113 383 FKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQ 441
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 233-326 1.27e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.50  E-value: 1.27e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271370 233 SSLFELHLDGNKI----TKVTADSLKGLK-NLSKLGLSHN---------------------EISVVENG----------- 275
Cdd:cd00116 108 SSLQELKLNNNGLgdrgLRLLAKGLKDLPpALEKLVLGRNrlegascealakalranrdlkELNLANNGigdagiralae 187

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 47271370 276 SLANVPHLRELHLENNALT-----AVPAGLADHKYIQVIYLHSNKIAAVGTEDFCP 326
Cdd:cd00116 188 GLKANCNLEVLDLNNNGLTdegasALAETLASLKSLEVLNLGDNNLTDAGAAALAS 243
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 70-174 1.60e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.11  E-value: 1.60e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271370  70 CQCHLRVAQCSDLGL---------KTVPEKIPLDTtlLDLQNNKITE-----IKEnDFKGLKGLQTLILVNNKIT----I 131
Cdd:cd00116 135 LPPALEKLVLGRNRLegascealaKALRANRDLKE--LNLANNGIGDagiraLAE-GLKANCNLEVLDLNNNGLTdegaS 211

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 47271370 132 IHAKAFSSLINLERLYLSKNLLKEVPA--------NIPKSLQELRIHENQI 174
Cdd:cd00116 212 ALAETLASLKSLEVLNLGDNNLTDAGAaalasallSPNISLLTLSLSCNDI 262
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 132-322 2.26e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 42.85  E-value: 2.26e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271370 132 IHAKAFSSLINLERLYLSKNLLKEVPA-------NIPKSLQELRIHENQINKIKKSSFAGM----ANVIVMELGSNPLSS 200
Cdd:COG5238 171 ISMAKALQNNSVETVYLGCNQIGDEGIeelaealTQNTTVTTLWLKRNPIGDEGAEILAEAlkgnKSLTTLDLSNNQIGD 250

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271370 201 SGVDngAFADLKRV---------SYIRIADTNLTSIPKGL--PSSLFELHLDGNKIT----KVTADSLKGLKNLSKLGLS 265
Cdd:COG5238 251 EGVI--ALAEALKNnttvetlylSGNQIGAEGAIALAKALqgNTTLTSLDLSVNRIGdegaIALAEGLQGNKTLHTLNLA 328

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 47271370 266 HNEISVVENGSLANV----PHLRELHLENNALTAVPA-GLAdhKYIQ------VIYLHSNKIAAVGTE 322
Cdd:COG5238 329 YNGIGAQGAIALAKAlqenTTLHSLDLSDNQIGDEGAiALA--KYLEgnttlrELNLGKNNIGKQGAE 394
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 103-184 3.53e-04

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 40.22  E-value: 3.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271370   103 NKITEIKENDFKGLKGLQTLILvNNKITIIHAKAFSSlINLERLYLSKNLLKevpanIPK-------SLQELRIHENqIN 175
Cdd:pfam13306  20 SSLTSIGEYAFSNCTSLKSITL-PSSLTSIGSYAFYN-CSLTSITIPSSLTS-----IGEyafsncsNLKSITLPSN-LT 91


                  ....*....
gi 47271370   176 KIKKSSFAG 184
Cdd:pfam13306  92 SIGSYAFSN 100
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 102-184 7.99e-04

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 39.07  E-value: 7.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271370   102 NNKITEIKENDFKGLKgLQTLILvNNKITIIHAKAFSSLINLERLYLSKNLLKevpanIPK------SLQELRIHENqIN 175
Cdd:pfam13306  42 PSSLTSIGSYAFYNCS-LTSITI-PSSLTSIGEYAFSNCSNLKSITLPSNLTS-----IGSyafsncSLKSITIPSS-VT 113


                  ....*....
gi 47271370   176 KIKKSSFAG 184
Cdd:pfam13306 114 TIGSYAFSN 122
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 98-317 2.47e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.83  E-value: 2.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271370   98 LDLQNNKIT-EIKENDFKGLKGLQTLILVNNKITiiHAKAFSSLINLERLYLSKNLLK-EVPANIpkslqelrihenqin 175
Cdd:PLN00113  98 INLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFT--GSIPRGSIPNLETLDLSNNMLSgEIPNDI--------------- 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47271370  176 kikkSSFAgmaNVIVMELGSNPLsssgvdngafadlkrVSYIRIADTNLTSipkglpssLFELHLDGNKITKVTADSLKG 255
Cdd:PLN00113 161 ----GSFS---SLKVLDLGGNVL---------------VGKIPNSLTNLTS--------LEFLTLASNQLVGQIPRELGQ 210

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 47271370  256 LKNLSKLGLSHNEIS---VVENGSLANVPHLRELHleNNALTAVPAGLADHKYIQVIYLHSNKIA 317
Cdd:PLN00113 211 MKSLKWIYLGYNNLSgeiPYEIGGLTSLNHLDLVY--NNLTGPIPSSLGNLKNLQYLFLYQNKLS 273
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 117-151 3.85e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.91  E-value: 3.85e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 47271370   117 KGLQTLILVNNKITIIhaKAFSSLINLERLYLSKN 151
Cdd:pfam12799   1 PNLEVLDLSNNQITDI--PPLAKLPNLETLDLSGN 33
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 257-291 8.64e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 33.76  E-value: 8.64e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 47271370   257 KNLSKLGLSHNEISVVENgsLANVPHLRELHLENN 291
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPP--LAKLPNLETLDLSGN 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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