NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|63054412|ref|NP_587767|]
View 

DinB-like DNA repair polymerase kappa [Schizosaccharomyces pombe]

Protein Classification

Y-family DNA polymerase( domain architecture ID 10132427)

Y-family DNA polymerase similar to DNA polymerase IV which is a poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis

CATH:  3.30.1490.100|3.30.70.270|2.30.40.20|1.10.150.810
EC:  2.7.7.7
Gene Ontology:  GO:0006281|GO:0003684|GO:0006260|GO:0046872|GO:0003887
PubMed:  15680965|24716551|20123134
SCOP:  4000563|4000558

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PolY_Pol_IV_kappa cd03586
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ...
 133-471 1.80e-126

DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.


:

Pssm-ID: 176459 [Multi-domain]  Cd Length: 334  Bit Score: 373.39  E-value: 1.80e-126
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412 133 VHVDCDAFYASIEELKNPKLKSLPMAVG----KSVLCTANYVARKFGVRSAMPEFIARKICPDLVVIPLNLSEYAIKSKE 208
Cdd:cd03586   1 IHIDMDAFYASVEQRDNPELKGKPVAVGgssdRGVVSTASYEARKFGVRSAMPIFQAKKLCPNLIFVPPRFDKYREVSRQ 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412 209 IQNVLAQYDSNLCPASIDEFYMNLTSHLRLQelaftvENITMVVEKIRKQVHEETGVTVSCGIAANKLLAKIASNKRKPN 288
Cdd:cd03586  81 IMEILREYTPLVEPLSIDEAYLDVTDYVRLF------GSATEIAKEIRARIREETGLTASAGIAPNKFLAKIASDLNKPN 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412 289 NQFFIPFDEigISKFMNDLPVREVSGIGRVLEQQLLGLEIKTCGDIQRNLVILSYIFLPKSFQNLLRCSYGFGTTILDEy 368
Cdd:cd03586 155 GLTVIPPED--VEEFLAPLPVRKIPGVGKVTAEKLKELGIKTIGDLAKLDVELLKKLFGKSGRRLYELARGIDNRPVEP- 231

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412 369 gESKRKTIGSEATFSSNLSSPSIIEYKLRLLVQNVSENLQKRGLVTNSIAIKYKTSEFQVHTKQKSIGQFIHSESDLLKP 448
Cdd:cd03586 232 -DRERKSIGVERTFSEDLTDPEELLEELLELAEELAERLRKRGLKGRTVTVKLKYADFSTRTRSRTLPEPTDDAEDIYEL 310

                       330       340
                ....*....|....*....|....
gi 63054412 449 ALQLLRQSYPM-TIRLLGVRATKL 471
Cdd:cd03586 311 ALELLEELLDGrPIRLLGVRLSGL 334
 
Name Accession Description Interval E-value
PolY_Pol_IV_kappa cd03586
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ...
 133-471 1.80e-126

DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.


Pssm-ID: 176459 [Multi-domain]  Cd Length: 334  Bit Score: 373.39  E-value: 1.80e-126
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412 133 VHVDCDAFYASIEELKNPKLKSLPMAVG----KSVLCTANYVARKFGVRSAMPEFIARKICPDLVVIPLNLSEYAIKSKE 208
Cdd:cd03586   1 IHIDMDAFYASVEQRDNPELKGKPVAVGgssdRGVVSTASYEARKFGVRSAMPIFQAKKLCPNLIFVPPRFDKYREVSRQ 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412 209 IQNVLAQYDSNLCPASIDEFYMNLTSHLRLQelaftvENITMVVEKIRKQVHEETGVTVSCGIAANKLLAKIASNKRKPN 288
Cdd:cd03586  81 IMEILREYTPLVEPLSIDEAYLDVTDYVRLF------GSATEIAKEIRARIREETGLTASAGIAPNKFLAKIASDLNKPN 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412 289 NQFFIPFDEigISKFMNDLPVREVSGIGRVLEQQLLGLEIKTCGDIQRNLVILSYIFLPKSFQNLLRCSYGFGTTILDEy 368
Cdd:cd03586 155 GLTVIPPED--VEEFLAPLPVRKIPGVGKVTAEKLKELGIKTIGDLAKLDVELLKKLFGKSGRRLYELARGIDNRPVEP- 231

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412 369 gESKRKTIGSEATFSSNLSSPSIIEYKLRLLVQNVSENLQKRGLVTNSIAIKYKTSEFQVHTKQKSIGQFIHSESDLLKP 448
Cdd:cd03586 232 -DRERKSIGVERTFSEDLTDPEELLEELLELAEELAERLRKRGLKGRTVTVKLKYADFSTRTRSRTLPEPTDDAEDIYEL 310

                       330       340
                ....*....|....*....|....
gi 63054412 449 ALQLLRQSYPM-TIRLLGVRATKL 471
Cdd:cd03586 311 ALELLEELLDGrPIRLLGVRLSGL 334
DinP COG0389
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ...
 131-469 5.21e-95

Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];


Pssm-ID: 440158 [Multi-domain]  Cd Length: 336  Bit Score: 292.82  E-value: 5.21e-95
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412 131 IIVHVDCDAFYASIEELKNPKLKSLPMAVG----KSVLCTANYVARKFGVRSAMPEFIARKICPDLVVIPLNLSEYAIKS 206
Cdd:COG0389   2 RILHVDMDAFYASVEQRDRPELRGKPVAVGgdnnRGVVAAASYEARAFGVRSGMPLFQARRLCPDLVVLPPDFELYRDVS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412 207 KEIQNVLAQYDSNLCPASIDEFYMNLTSHLRLqelaftVENITMVVEKIRKQVHEETGVTVSCGIAANKLLAKIASNKRK 286
Cdd:COG0389  82 RRVMAILERYTPLVEPLSIDEAFLDVTGSARL------FGSAEAIARRIRRRIRRETGLTVSVGIAPNKFLAKIASDLAK 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412 287 PNNQFFIPFDEigISKFMNDLPVREVSGIGRVLEQQLLGLEIKTCGDIQRnlviLSYIFLPKSF----QNLLRCSYGFGT 362
Cdd:COG0389 156 PDGLTVIPPGE--VAAFLAPLPVEKLWGVGPKTAEKLARLGIRTIGDLAA----LPRAELRRRFgkvgERLYRLARGIDP 229

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412 363 TILDEYGEskRKTIGSEATFSSNLSSPSIIEYKLRLLVQNVSENLQKRGLVTNSIAIKYKTSEFQVHTKQKSIGQFIHSE 442
Cdd:COG0389 230 RPVEPRRP--RKSIGVERTFGEDLTDLEELEAALRRLAERLAERLRRQGLGARTVTVKLRTSDFRTTTRSRTLPEPTDDT 307

                       330       340
                ....*....|....*....|....*....
gi 63054412 443 SDLLKPALQLLRQSYP--MTIRLLGVRAT 469
Cdd:COG0389 308 AELLRAARELLERIYRpgRPVRLLGVRLS 336
PRK02406 PRK02406
DNA polymerase IV; Validated
 137-466 2.88e-82

DNA polymerase IV; Validated


Pssm-ID: 235035 [Multi-domain]  Cd Length: 343  Bit Score: 260.05  E-value: 2.88e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412  137 CDAFYASIEELKNPKLKSLPMAVGKS-----VLCTANYVARKFGVRSAMPEFIARKICPDLVVIPLNLSEYAIKSKEIQN 211
Cdd:PRK02406   1 MDCFYAAVEMRDNPELRGKPVAVGGSpgrrgVISTCNYEARKFGVRSAMPTAQALKLCPDLIFVPGRFDVYKEVSRQIRE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412  212 VLAQYDSNLCPASIDEFYMNLTSHLRLQELAftveniTMVVEKIRKQVHEETGVTVSCGIAANKLLAKIASNKRKPNNQF 291
Cdd:PRK02406  81 IFRRYTDLIEPLSLDEAYLDVTDNKLCIGSA------TLIAQEIRQDIFEELGLTASAGVAPNKFLAKIASDWNKPNGLF 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412  292 FIPFDEigISKFMNDLPVREVSGIGRVLEQQLLGLEIKTCGDIQRnlviLSYIFLPKSF----QNLLRCSYGfgttiLDE 367
Cdd:PRK02406 155 VITPEE--VDAFLATLPVEKIPGVGKVTAEKLHALGIYTCADLQK----YDLAELIRHFgkfgRRLYERARG-----IDE 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412  368 YG---ESKRKTIGSEATFSSNLSSPSIIEYKLRLLVQNVSENLQKRG--LVTNSIAIKYKTSEFQVHTKQKSiGQFIHSE 442
Cdd:PRK02406 224 RPvkpDRERKSVGVERTFAEDLYDLEACLAELPRLAEKLERRLERAKpdKRIKTVGVKLKFADFQQTTKEHT-ADPLDKA 302

                        330       340
                 ....*....|....*....|....
gi 63054412  443 SDLLKPALQLLRQSYPMTIRLLGV 466
Cdd:PRK02406 303 DLIELLAQALLRRLGGRGVRLLGV 326
IMS pfam00817
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
 135-283 1.29e-54

impB/mucB/samB family; These proteins are involved in UV protection (Swiss).


Pssm-ID: 425885 [Multi-domain]  Cd Length: 148  Bit Score: 181.23  E-value: 1.29e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412   135 VDCDAFYASIEELKNPKLKSLPMAVG----KSVLCTANYVARKFGVRSAMPEFIARKICPDLVVIPLNLSEYAIKSKEIQ 210
Cdd:pfam00817   1 IDMDAFFASVELLRDPELKGKPVAVGggngRGIVAAASYEARKYGVRSGMPVFEAKKLCPNLIVVPPDLELYRRASRKIF 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 63054412   211 NVLAQYDSNLC-PASIDEFYMNLTSHLRLQElafTVENItmvVEKIRKQVHEETGVTVSCGIAANKLLAKIASN 283
Cdd:pfam00817  81 EILRRFSTPKVeQASIDEAFLDLTGLEKLFG---AEEAL---AKRLRREIAEETGLTCSIGIAPNKLLAKLASD 148
 
Name Accession Description Interval E-value
PolY_Pol_IV_kappa cd03586
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ...
 133-471 1.80e-126

DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.


Pssm-ID: 176459 [Multi-domain]  Cd Length: 334  Bit Score: 373.39  E-value: 1.80e-126
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412 133 VHVDCDAFYASIEELKNPKLKSLPMAVG----KSVLCTANYVARKFGVRSAMPEFIARKICPDLVVIPLNLSEYAIKSKE 208
Cdd:cd03586   1 IHIDMDAFYASVEQRDNPELKGKPVAVGgssdRGVVSTASYEARKFGVRSAMPIFQAKKLCPNLIFVPPRFDKYREVSRQ 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412 209 IQNVLAQYDSNLCPASIDEFYMNLTSHLRLQelaftvENITMVVEKIRKQVHEETGVTVSCGIAANKLLAKIASNKRKPN 288
Cdd:cd03586  81 IMEILREYTPLVEPLSIDEAYLDVTDYVRLF------GSATEIAKEIRARIREETGLTASAGIAPNKFLAKIASDLNKPN 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412 289 NQFFIPFDEigISKFMNDLPVREVSGIGRVLEQQLLGLEIKTCGDIQRNLVILSYIFLPKSFQNLLRCSYGFGTTILDEy 368
Cdd:cd03586 155 GLTVIPPED--VEEFLAPLPVRKIPGVGKVTAEKLKELGIKTIGDLAKLDVELLKKLFGKSGRRLYELARGIDNRPVEP- 231

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412 369 gESKRKTIGSEATFSSNLSSPSIIEYKLRLLVQNVSENLQKRGLVTNSIAIKYKTSEFQVHTKQKSIGQFIHSESDLLKP 448
Cdd:cd03586 232 -DRERKSIGVERTFSEDLTDPEELLEELLELAEELAERLRKRGLKGRTVTVKLKYADFSTRTRSRTLPEPTDDAEDIYEL 310

                       330       340
                ....*....|....*....|....
gi 63054412 449 ALQLLRQSYPM-TIRLLGVRATKL 471
Cdd:cd03586 311 ALELLEELLDGrPIRLLGVRLSGL 334
DinP COG0389
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ...
 131-469 5.21e-95

Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];


Pssm-ID: 440158 [Multi-domain]  Cd Length: 336  Bit Score: 292.82  E-value: 5.21e-95
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412 131 IIVHVDCDAFYASIEELKNPKLKSLPMAVG----KSVLCTANYVARKFGVRSAMPEFIARKICPDLVVIPLNLSEYAIKS 206
Cdd:COG0389   2 RILHVDMDAFYASVEQRDRPELRGKPVAVGgdnnRGVVAAASYEARAFGVRSGMPLFQARRLCPDLVVLPPDFELYRDVS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412 207 KEIQNVLAQYDSNLCPASIDEFYMNLTSHLRLqelaftVENITMVVEKIRKQVHEETGVTVSCGIAANKLLAKIASNKRK 286
Cdd:COG0389  82 RRVMAILERYTPLVEPLSIDEAFLDVTGSARL------FGSAEAIARRIRRRIRRETGLTVSVGIAPNKFLAKIASDLAK 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412 287 PNNQFFIPFDEigISKFMNDLPVREVSGIGRVLEQQLLGLEIKTCGDIQRnlviLSYIFLPKSF----QNLLRCSYGFGT 362
Cdd:COG0389 156 PDGLTVIPPGE--VAAFLAPLPVEKLWGVGPKTAEKLARLGIRTIGDLAA----LPRAELRRRFgkvgERLYRLARGIDP 229

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412 363 TILDEYGEskRKTIGSEATFSSNLSSPSIIEYKLRLLVQNVSENLQKRGLVTNSIAIKYKTSEFQVHTKQKSIGQFIHSE 442
Cdd:COG0389 230 RPVEPRRP--RKSIGVERTFGEDLTDLEELEAALRRLAERLAERLRRQGLGARTVTVKLRTSDFRTTTRSRTLPEPTDDT 307

                       330       340
                ....*....|....*....|....*....
gi 63054412 443 SDLLKPALQLLRQSYP--MTIRLLGVRAT 469
Cdd:COG0389 308 AELLRAARELLERIYRpgRPVRLLGVRLS 336
PRK02406 PRK02406
DNA polymerase IV; Validated
 137-466 2.88e-82

DNA polymerase IV; Validated


Pssm-ID: 235035 [Multi-domain]  Cd Length: 343  Bit Score: 260.05  E-value: 2.88e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412  137 CDAFYASIEELKNPKLKSLPMAVGKS-----VLCTANYVARKFGVRSAMPEFIARKICPDLVVIPLNLSEYAIKSKEIQN 211
Cdd:PRK02406   1 MDCFYAAVEMRDNPELRGKPVAVGGSpgrrgVISTCNYEARKFGVRSAMPTAQALKLCPDLIFVPGRFDVYKEVSRQIRE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412  212 VLAQYDSNLCPASIDEFYMNLTSHLRLQELAftveniTMVVEKIRKQVHEETGVTVSCGIAANKLLAKIASNKRKPNNQF 291
Cdd:PRK02406  81 IFRRYTDLIEPLSLDEAYLDVTDNKLCIGSA------TLIAQEIRQDIFEELGLTASAGVAPNKFLAKIASDWNKPNGLF 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412  292 FIPFDEigISKFMNDLPVREVSGIGRVLEQQLLGLEIKTCGDIQRnlviLSYIFLPKSF----QNLLRCSYGfgttiLDE 367
Cdd:PRK02406 155 VITPEE--VDAFLATLPVEKIPGVGKVTAEKLHALGIYTCADLQK----YDLAELIRHFgkfgRRLYERARG-----IDE 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412  368 YG---ESKRKTIGSEATFSSNLSSPSIIEYKLRLLVQNVSENLQKRG--LVTNSIAIKYKTSEFQVHTKQKSiGQFIHSE 442
Cdd:PRK02406 224 RPvkpDRERKSVGVERTFAEDLYDLEACLAELPRLAEKLERRLERAKpdKRIKTVGVKLKFADFQQTTKEHT-ADPLDKA 302

                        330       340
                 ....*....|....*....|....
gi 63054412  443 SDLLKPALQLLRQSYPMTIRLLGV 466
Cdd:PRK02406 303 DLIELLAQALLRRLGGRGVRLLGV 326
PTZ00205 PTZ00205
DNA polymerase kappa; Provisional
 13-473 2.43e-64

DNA polymerase kappa; Provisional


Pssm-ID: 140232 [Multi-domain]  Cd Length: 571  Bit Score: 219.89  E-value: 2.43e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412   13 KENGLLTIEDDGSSSSDEEATLKRRLAGPSVL-------------KSGQENVNQKKINEIIYEASKGSKFFEAEQK--RD 77
Cdd:PTZ00205   5 EENGGLDQAHVSYSGSASEQNIAEMIVDPSGSrqptafqltldcnKAGMGNVDKERVEAIIRNVSEGSSFLMNEQRlaEG 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412   78 RELRLRIEKVQVEVEKYQSKLRFDKAFQREWTIRQESVDTTVEdfrAKRDLTQIIvHVDCDAFYASIEELKNPKLKSLPM 157
Cdd:PTZ00205  85 REKQLQELKRKSSLFTQLLGGERNAAQRKQWELKVSKIEQELE---ATRRLGTYI-HLDMDMFYAAVEIKKHPEYAAIPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412  158 AVG-KSVLCTANYVARKFGVRSAMPEFIARKICPDLVVIPLNLSEYAIKSKEIQNVLAQYDSNLCPASIDEFYMNLTSHL 236
Cdd:PTZ00205 161 AIGtMTMLQTANYVARGRGIRQGMPGFLALKICPNLLILPPDFDAYNEESNTVRRIVAEYDPNYISFGLDELTLEVSAYI 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412  237 RLQELAFTVENitmVVEKIRKQVHEETGVTVSCGIAANKLLAKIASNKRKPNNQFFIPFDEIG-ISKFMNDLPVREVSGI 315
Cdd:PTZ00205 241 ERFEGTKTAED---VASELRVRVFGETKLTASAGIGPTAALAKIASNINKPNGQHDLNLHTRGdVMTYVRDLGLRSVPGV 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412  316 GRVLEQQLLGLEIKTCGDIQRNLVILSYIFLPKSFQNLLRCSYGF----------GTTILDEYGESKRKTIGSEATFSSn 385
Cdd:PTZ00205 318 GKVTEALLKGLGITTLSDIYNRRVELCYILHNNLFRFLLGASIGImqwpdaataaNTENCEGATGGQRKAISSERSFTT- 396

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412  386 LSSPSIIEYKLRLLVQNVSENLQKRGLVTNSIAIKYKTSEFQVHTKQKSIGQFIHSESDLLKPALQLL--RQSYPMTIRL 463
Cdd:PTZ00205 397 PRTKEGLQEMVDTVFNGAYEEMRKSELMCRQISLTIRWASYRYQQYTKSLIQYSDDSATLRRAVDGLLlpHAAKYSEMCL 476

                        490
                 ....*....|
gi 63054412  464 LGVRATKLVS 473
Cdd:PTZ00205 477 LGVRFLDLIS 486
PRK02794 PRK02794
DNA polymerase IV; Provisional
 132-476 3.45e-62

DNA polymerase IV; Provisional


Pssm-ID: 179473 [Multi-domain]  Cd Length: 419  Bit Score: 210.17  E-value: 3.45e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412  132 IVHVDCDAFYASIEELKNPKLKSLPMAVG---KSVLCTANYVARKFGVRSAMPEFIARKICPDLVVIPLNLSEYAIKSKE 208
Cdd:PRK02794  38 IAHIDCDAFYASVEKRDNPELRDKPVIIGggkRGVVSTACYIARIHGVRSAMPMFKALKLCPDAVVIKPDMEKYVRVGRE 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412  209 IQNVLAQYDSNLCPASIDEFYMNLTSHLRLQELAFTVenitmVVEKIRKQVHEETGVTVSCGIAANKLLAKIASNKRKPN 288
Cdd:PRK02794 118 VRAMMQALTPLVEPLSIDEAFLDLSGTERLHGAPPAV-----VLARFARRVEREIGITVSVGLSYNKFLAKIASDLDKPR 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412  289 NqffipFDEIGISK---FMNDLPVREVSGIGRVLEQQLLGLEIKTCGDIQRnlviLSYIFLPKSF----QNLLRCSYGFG 361
Cdd:PRK02794 193 G-----FSVIGRAEalaFLAPKPVGIIWGVGPATAARLARDGIRTIGDLQR----ADEADLMRRFgsmgLRLWRLARGID 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412  362 TTILDeyGESKRKTIGSEATFSSNLSSPSIIEYKLRLLVQNVSENLQKRGLVTNSIAIKYKTSEFQVHTKQKSIGQFIHS 441
Cdd:PRK02794 264 DRKVS--PDREAKSVSAETTFETDLSDFEDLEPILWRLSEKVSRRLKAAGLAGRTVTLKLKTADFRLRTRRRTLEDPTQL 341

                        330       340       350
                 ....*....|....*....|....*....|....*.
gi 63054412  442 ESDLLKPALQLLRQSYPMT-IRLLGVRATKLVSKSR 476
Cdd:PRK02794 342 ADRIFRTARELLEKETDGTaFRLIGIGVSDLSPADE 377
PRK01810 PRK01810
DNA polymerase IV; Validated
 131-474 1.60e-58

DNA polymerase IV; Validated


Pssm-ID: 179337 [Multi-domain]  Cd Length: 407  Bit Score: 199.87  E-value: 1.60e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412  131 IIVHVDCDAFYASIEELKNPKLKSLPMAVG------KSVLCTANYVARKFGVRSAMPEFIARKICPDLVVIPLNLSEYAI 204
Cdd:PRK01810   6 VIFHVDMNSFFASVEIAYDPSLQGKPLAVAgnekerKGIIVTCSYEARAYGIRTTMPLWEAKRLCPQLIVRRPNFDRYRE 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412  205 KSKEIQNVLAQYDSNLCPASIDEFYMNLTSHLRLQ---ELAftvenitmvvEKIRKQVHEETGVTVSCGIAANKLLAKIA 281
Cdd:PRK01810  86 ASRQMFQILSEFTPLVQPVSIDEGYLDITDCYALGsplEIA----------KMIQQRLLTELQLPCSIGIAPNKFLAKMA 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412  282 SNKRKPNnqffipfdeiGIS--------KFMNDLPVREVSGIGRVLEQQLLGLEIKTCGDIQR-NLVILSYIFlPKSFQN 352
Cdd:PRK01810 156 SDMKKPL----------GITvlrkrdvpEMLWPLPVGEMHGIGEKTAEKLKDIGIQTIGDLAKaDEHILRAKL-GINGVR 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412  353 LLRCSYGFGTTILDEYGESKRKTIGSEATFSSNLSSPSIIEYKLRLLVQNVSENLQKRGLVTNSIAIKYKTSEFQVHTKQ 432
Cdd:PRK01810 225 LQRRANGIDDRPVDPEAIYQFKSVGNSTTLSHDMDEEKELLDVLRRLSKSVSKRLQKKTVVSYNVQIMIRYHDRRTITRS 304

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 63054412  433 KSIGQFIHSESDLLKPALQLLRQSY---PmtIRLLGVRATKLVSK 474
Cdd:PRK01810 305 KTLKNPIWEKRDIFQAASRLFKQHWngdP--VRLLGVTATDLEWK 347
PRK14133 PRK14133
DNA polymerase IV; Provisional
 131-471 3.30e-56

DNA polymerase IV; Provisional


Pssm-ID: 184529 [Multi-domain]  Cd Length: 347  Bit Score: 192.24  E-value: 3.30e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412  131 IIVHVDCDAFYASIEELKNPKLKSLPMAVG----KSVLCTANYVARKFGVRSAMPEFIARKICPDLVVIPLNLSEYAIKS 206
Cdd:PRK14133   4 VIIHVDMDAFFASVEQMDNPKLKGKPVIVGgiseRGVVSTCSYEARKYGVHSAMPVFMAKKRCPHGIFLPVRHERYKEVS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412  207 KEIQNVLAQYDSNLCPASIDEFYMNLTShlrlqelafTVENITMVVEKIRKQVHEETGVTVSCGIAANKLLAKIASNKRK 286
Cdd:PRK14133  84 KNIFKILYEVTPIVEPVSIDEAYLDITN---------IKEEPIKIAKYIKKKVKKETGLTLSVGISYNKFLAKLASDWNK 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412  287 PNNQFFIPFDEigISKFMNDLPVREVSGIGRVLEQQLLGLEIKTCGDIQRnlvilsyifLPKsfQNLLRCSYGFGTTILD 366
Cdd:PRK14133 155 PDGIKIITEDM--IPDILKPLPISKVHGIGKKSVEKLNNIGIYTIEDLLK---------LSR--EFLIEYFGKFGVEIYE 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412  367 EYG---------ESKRKTIGSEATFSSNLSSPSIIEYKLRLLVQNVSENLQKRGLVTNSIAIKYKTSEFQVHTKQKSIGQ 437
Cdd:PRK14133 222 RIRgidyrevevSRERKSIGKETTLKKDTKDKEELKKYLKDFSNIISEELKKRNLYGKTVTVKIKTSDFQTHTKSKTLND 301

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 63054412  438 FIHSESDLLKPALQLLRQS-YPMTIRLLGVRATKL 471
Cdd:PRK14133 302 YIRDKEEIYNVACEILEHInIKEPIRLIGLSVSNL 336
IMS pfam00817
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
 135-283 1.29e-54

impB/mucB/samB family; These proteins are involved in UV protection (Swiss).


Pssm-ID: 425885 [Multi-domain]  Cd Length: 148  Bit Score: 181.23  E-value: 1.29e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412   135 VDCDAFYASIEELKNPKLKSLPMAVG----KSVLCTANYVARKFGVRSAMPEFIARKICPDLVVIPLNLSEYAIKSKEIQ 210
Cdd:pfam00817   1 IDMDAFFASVELLRDPELKGKPVAVGggngRGIVAAASYEARKYGVRSGMPVFEAKKLCPNLIVVPPDLELYRRASRKIF 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 63054412   211 NVLAQYDSNLC-PASIDEFYMNLTSHLRLQElafTVENItmvVEKIRKQVHEETGVTVSCGIAANKLLAKIASN 283
Cdd:pfam00817  81 EILRRFSTPKVeQASIDEAFLDLTGLEKLFG---AEEAL---AKRLRREIAEETGLTCSIGIAPNKLLAKLASD 148
PolY_Rev1 cd01701
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. ...
 102-420 5.73e-47

DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Rev1 has both structural and enzymatic roles. Structurally, it is believed to interact with other nonclassical polymerases and replication machinery to act as a scaffold. Enzymatically, it catalyzes the specific insertion of dCMP opposite abasic sites. Rev1 interacts with the Rev7 subunit of the B-family TLS polymerase Pol zeta (Rev3/Rev7). Rev1 is known to actively promote the introduction of mutations, potentially making it a significant target for cancer treatment.


Pssm-ID: 176455 [Multi-domain]  Cd Length: 404  Bit Score: 169.03  E-value: 5.73e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412 102 KAFQREWTIRQESVDTTVEDFRakrDLTQIIVHVDCDAFYASIEELKNPKLKSLPMAVGKSVLCTA-----NYVARKFGV 176
Cdd:cd01701  22 KDFFRELSNGSKEADPSNSIHP---DLQRIIMHVDFDCFFVSVSIRNRPDLKGKPVAVCHGKGPNSeiascNYEARSYGI 98

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412 177 RSAMPEFIARKICPDLVVIPLNLSEYAIKSKEIQNVLAQYDSNLCPASIDEFYMNLTSHLrlqelAFTVENITMVVEKIR 256
Cdd:cd01701  99 KNGMWVGQAKKLCPQLVTLPYDFEAYEEVSLTFYEILASYTDNIEAVSCDEALIDITSLL-----EETYELPEELAEAIR 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412 257 KQVHEETGVTVSCGIAANKLLAKIASNKRKPNNQFFIPFDEigISKFMNDLPVREVSGIGRVLEQQLLGLEIKTCGDIQ- 335
Cdd:cd01701 174 NEIRETTGCSASVGIGPNILLARLATRKAKPDGQYHLSAEK--VEEFLSQLKVGDLPGVGSSLAEKLVKLFGDTCGGLEl 251

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412 336 --RNLVILSYIFLPKSFQNLLRCSYGFGTTILDEYGEskRKTIGSEATFSSNLSSPSIIEYKLRLLVQNVSENLQKRGLV 413
Cdd:cd01701 252 rsKTKEKLQKVLGPKTGEKLYDYCRGIDDRPVTGEKE--RKSVSAEINYGIRFTNVDDVEQFLQRLSEELSKRLEESNVT 329


                ....*..
gi 63054412 414 TNSIAIK 420
Cdd:cd01701 330 GRQITLK 336
PolY cd00424
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases ...
 133-467 5.73e-44

Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Most TLS polymerases are members of the Y-family, including Pol eta, Pol kappa/IV, Pol iota, Rev1, and Pol V, which is found exclusively in bacteria. In eukaryotes, the B-family polymerase Pol zeta also functions as a TLS polymerase. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.


Pssm-ID: 176453 [Multi-domain]  Cd Length: 343  Bit Score: 159.06  E-value: 5.73e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412 133 VHVDCDAFYASIEELKNPKLKSLPMAV-----GKSVLCTANYVARKFGVRSAMPEFIARKICPDLVVIPLNLSEYAIKSK 207
Cdd:cd00424   1 LHIDFDNFFASVEQLARPELKGRPVVVvpfnsDSTCVIACSYEARKYGVKRGMPVREARKMCPNLILVPARLDLYRRLSE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412 208 EIQNVLAQYDSNLCPASIDEFYMNLTSHLRLQELAftveniTMVVEKIRKQVHEETG-VTVSCGIAANKLLAKIASNKRK 286
Cdd:cd00424  81 RLLSELEEVAPLVEVASIDELFLDLTGSARLLGLG------SEVALRIKRHIAEQLGgITASIGIASNKLLAKLAAKYAK 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412 287 PNNQFFIPFDEigISKFMNDLPVREVSGIGRVLEQQLLGLEIKTCGDIQ----RNLVILSYIFLPKSFQNLLRcsygfgt 362
Cdd:cd00424 155 PDGLTILDPED--LPGFLSKLPLTDLPGIGAVTAKRLEAVGINPIGDLLaaspDALLALWGGVSGERLWYALR------- 225

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412 363 tilDEYGE-----SKRKTIGSEATFSSNLSSPSIIEYKLRLLVQNVSENLQKRGLVTN--SIAIKYKTSEFQ----VHTK 431
Cdd:cd00424 226 ---GIDDEplsppRPRKSFSHERVLPRDSRNAEDARPLLRLLLEKLARRLRRDGRGATrlRLWLRTVDGRWSghadIPSR 302

                       330       340       350
                ....*....|....*....|....*....|....*....
gi 63054412 432 QKSIGQFIHSES--DLLKPALQ-LLRQSYPMTIRLLGVR 467
Cdd:cd00424 303 SAPRPISTEDGEllHALDKLWRaLLDDKGPRRLRRLGVR 341
PRK03348 PRK03348
DNA polymerase IV; Provisional
 132-466 2.92e-41

DNA polymerase IV; Provisional


Pssm-ID: 235118 [Multi-domain]  Cd Length: 454  Bit Score: 154.32  E-value: 2.92e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412  132 IVHVDCDAFYASIEELKNPKLKSLPMAVG----KSVLCTANYVARKFGVRSAMPEFIARKICPDL-VVIPLNLSEYAIKS 206
Cdd:PRK03348   7 VLHLDMDAFFASVEQLTRPTLRGRPVLVGglggRGVVAGASYEARVFGARSAMPMHQARRLVGNGaVVLPPRFVVYRAAS 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412  207 KEIQNVLAQYDSNLCPASIDEFYMNLtshlrlQELA-FTVENITMVVEKIRKQVHEETGVTVSCGIAANKLLAKIASNKR 285
Cdd:PRK03348  87 RRVFDTLRELSPVVEQLSFDEAFVEP------AELAgASAEEVEAFAERLRARVREETGLPASVGAGSGKQIAKIASGLA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412  286 KPNNQFFIPFDEigISKFMNDLPVREVSGIGRVLEQQLLGLEIKTCGDIQRnlviLSyiflPKSFQNLLrcsygfGTTI- 364
Cdd:PRK03348 161 KPDGIRVVPPGE--ERELLAPLPVRRLWGIGPVTEEKLHRLGIETIGDLAA----LS----EAEVANLL------GATVg 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412  365 ---------LDEYGESKR---KTIGSEATFSSNLSSPSIIEYKLRLLVQNVSENLQKRGLVTNSIAIKYKTSEFQVHTKQ 432
Cdd:PRK03348 225 palhrlargIDDRPVAERaeaKQISAESTFAVDLTTRAQLREAIERIAEHAHRRLLKDGRGARTVTVKLRKSDFSTLTRS 304

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 63054412  433 KSIGQFIHSESDLLKPALQLLRqsYPMT---IRLLGV 466
Cdd:PRK03348 305 ATLPYATDDAAVLAATARRLLL--DPDEigpIRLVGV 339
PRK03103 PRK03103
DNA polymerase IV; Reviewed
 131-473 4.90e-40

DNA polymerase IV; Reviewed


Pssm-ID: 235104 [Multi-domain]  Cd Length: 409  Bit Score: 150.15  E-value: 4.90e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412  131 IIVHVDCDAFYASIEELKNPKLKSLPMAVG------KSVLCTANYVARKFGVRSAMPEFIARKICPDLVVIPLNLSEYAI 204
Cdd:PRK03103   4 VILLVDMQSFYASVEKAANPELKGRPVIVSgdperrSGVVLAACPLAKAYGVKTAERLWEAQQKCPDLVVVKPRMQRYID 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412  205 KSKEIQNVLAQYDSNLCPASIDEFYMNLTSHLRL----QELAftvenitmvvEKIRKQVHEETGVTVSCGIAANKLLAKI 280
Cdd:PRK03103  84 VSLQITRILEDFTDLVEPFSIDEQFLDVTGSQKLfgspLEIA----------QKIQQRIMRETGVYARVGIGPNKLLAKM 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412  281 ASN---KRKPNNQFFIPFDEigISKFMNDLPVREVSGIGRVLEQQLLGLEIKTCGDIQRNLVILsyifLPKSF----QNL 353
Cdd:PRK03103 154 ACDnfaKKNPDGLFTLDKED--VPADLWPLPVRKLFGVGSRMEKHLRRMGIRTIGQLANTPLER----LKKRWgingEVL 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412  354 LRCSYGFGTTILDEYGESKRKTIGSEATFSSNLSSPSIIEYKLRLLVQNVSENLQKRGLVTNSIAIKYKTSEFQVHT--- 430
Cdd:PRK03103 228 WRTANGIDYSPVTPHSLDRQKAIGHQMTLPRDYRGFEEIKVVLLELCEEVCRRARAKGYMGRTVSVSLRGADFDWPTgfs 307

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 63054412  431 KQKSIGQFIHSESDLLKPALQLLRQSYPMT-IRLLGVRATKLVS 473
Cdd:PRK03103 308 RQMTLPEPTNLAMEVYEAACKLFHRHWDGKpVRRVGVTLSNLVS 351
PRK03858 PRK03858
DNA polymerase IV; Validated
 132-482 1.19e-38

DNA polymerase IV; Validated


Pssm-ID: 179663 [Multi-domain]  Cd Length: 396  Bit Score: 145.90  E-value: 1.19e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412  132 IVHVDCDAFYASIEELKNPKLKSLPMAVGKSVLCTANYVARKFGVRSAMPEFIARKICPDLVVIPLNLSEYAIKSKEIQN 211
Cdd:PRK03858   6 ILHADLDSFYASVEQRDDPALRGRPVIVGGGVVLAASYEAKAYGVRTAMGGRQARRLCPQAVVVPPRMSAYSRASKAVFE 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412  212 VLAQYDSNLCPASIDEFYMNLTShlrLQELAFTVENITmvvEKIRKQVHEETGVTVSCGIAANKLLAKIASNKRKPNNQF 291
Cdd:PRK03858  86 VFRDTTPLVEGLSIDEAFLDVGG---LRRISGTPVQIA---ARLRRRVREEVGLPITVGVARTKFLAKVASQVAKPDGLL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412  292 FIPFD-EIgisKFMNDLPVREVSGIGRVLEQQLLGLEIKTCGDIQR-NLVILSYIFLPKSFQNLLRCSYGFGTTILDEYG 369
Cdd:PRK03858 160 VVPPDrEL---AFLHPLPVRRLWGVGPVTAAKLRAHGITTVGDVAElPESALVSLLGPAAGRHLHALAHNRDPRRVETGR 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412  370 esKRKTIGSEATFSSNLSSPSIIEYKLRLLVQNVSENLQKRGLVTNSIAIKYKTSEFQVHTKQKSIGQFIHSESDLLKPA 449
Cdd:PRK03858 237 --RRRSVGAQRALGRGPNSPAEVDAVVVALVDRVARRMRAAGRTGRTVVLRLRFDDFTRATRSHTLPRPTASTATLLAAA 314

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 63054412  450 LQLLRQSYPM----TIRLLGVRATKLVsksRCLAMQL 482
Cdd:PRK03858 315 RDLVAAAAPLiaerGLTLVGFAVSNLD---DDGAQQL 348
PolY_Pol_V_umuC cd01700
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion ...
 135-457 2.11e-37

umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion synthesis (TLS) polymerase that consists of the heterotrimer of one umuC and two umuD subunits. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol V, RecA, single stranded DNA-binding protein, beta sliding clamp, and gamma clamp loading complex are responsible for inducing the SOS response in bacteria to repair UV-induced DNA damage.


Pssm-ID: 176454 [Multi-domain]  Cd Length: 344  Bit Score: 141.15  E-value: 2.11e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412 135 VDCDAFYASIEELKNPKLKSLPMAV----GKSVLcTANYVARKFGVRSAMPEFIARKICPDL--VVIPLNLSEYAIKSKE 208
Cdd:cd01700   3 VDCNSFYASCERVFRPLLLGRPLVVlsnnDGCVI-ARSPEAKALGIKMGSPYFKVPDLLERHgvAVFSSNYALYGDMSRR 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412 209 IQNVLAQYDSNLCPASIDEFYMNLTSHLR---LQELAftvenitmvvEKIRKQVHEETGVTVSCGIAANKLLAKIASN-- 283
Cdd:cd01700  82 IMSILERFSPDVEVYSIDESFLDLTGSLRfgdLEELA----------RKIRRRILQETGIPVTVGIGPTKTLAKLANDla 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412 284 KRKPNNQFFIPFDEIGIS-KFMNDLPVREVSGIGRVLEQQLLGLEIKTCGDIQRnlviLSYIFLPKSF----QNLLRCSY 358
Cdd:cd01700 152 KKKNPYGGVVDLTDEEVRdKLLKILPVGDVWGIGRRTAKKLNAMGIHTAGDLAQ----ADPDLLRKKFgvvgERLVRELN 227

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412 359 GFGTTILDEYgESKRKTIGSEATFSSNLSSPSIIEYKLRLLVQNVSENLQKRGLVTNSIAIKYKTSEFQVHTKQKSIGQF 438
Cdd:cd01700 228 GIDCLPLEEY-PPPKKSIGSSRSFGRDVTDLDELKQALAEYAERAAEKLRRQKSVARTISVFIGTSGFSRQPKYYSATNT 306

                       330       340
                ....*....|....*....|...
gi 63054412 439 IHSES----DLLKPALQLLRQSY 457
Cdd:cd01700 307 LPYPTndtrEIVKAALRLLYAIY 329
PRK03352 PRK03352
DNA polymerase IV; Validated
 129-468 5.84e-37

DNA polymerase IV; Validated


Pssm-ID: 179564 [Multi-domain]  Cd Length: 346  Bit Score: 140.16  E-value: 5.84e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412  129 TQIIVHVDCDAFYASIEELKNPKLKSLPMAVG--------KSVLCTANYVARKFGVRSAMPEFIARKICPDLVVIPLNLS 200
Cdd:PRK03352   4 PRWVLHVDLDQFIAAVELLRRPELAGLPVIVGgngdptepRKVVTCASYEARAFGVRAGMPLRTAARRCPDAVFLPSDPA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412  201 EYAIKSKEIQNVLAQYDSNLCPASIDEFYmnltshlrlqeLAFTVENITMVVEKIRKQVHEETGVTVSCGIAANKLLAKI 280
Cdd:PRK03352  84 AYDAASEEVMATLRDLGVPVEVWGWDEAF-----------LGVDTDDPEALAEEIRAAVLERTGLSCSVGIGDNKLRAKI 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412  281 ASNKRKPNNQFFIpfDEIGISKFMNDLPVREVSGIGRVLEQQLLGLEIKTCGDIQR-NLVILSYIFLPKSFQNLLRCSYG 359
Cdd:PRK03352 153 ATGFAKPAGVFRL--TDANWMAVMGDRPTDALWGVGPKTAKRLAALGITTVADLAAaDPAELAATFGPTTGPWLLLLARG 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412  360 FG-TTILDEYGESKRKtiGSEATFSSNLSSPSIIEYKLRLLVQNVSENLQKRGLVTNSIAIKYKTSEFQVHTKQKSIGQF 438
Cdd:PRK03352 231 GGdTEVSAEPWVPRSR--SREVTFPQDLTDRAEVESAVRELARRVLDEVVAEGRPVTRVAVKVRTATFYTRTKIRKLPEP 308

                        330       340       350
                 ....*....|....*....|....*....|...
gi 63054412  439 IHSESDLLKPALQLLRQ---SYPmtIRLLGVRA 468
Cdd:PRK03352 309 TTDPDVIEAAALDVLDRfelDRP--VRLLGVRL 339
PRK01216 PRK01216
DNA polymerase IV; Validated
 131-475 1.55e-36

DNA polymerase IV; Validated


Pssm-ID: 179251 [Multi-domain]  Cd Length: 351  Bit Score: 139.15  E-value: 1.55e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412  131 IIVHVDCDAFYASIEELKNPKLKSLPMAV----GKS----VLCTANYVARKFGVRSAMPEFIARKICPDLVVIPLNLSEY 202
Cdd:PRK01216   2 IILFVDFDYFFAQVEEVLNPSLKGKPVVVcvysGRFedsgAVATANYEARKLGIKAGMPIVEAKKILPNAVYLPMRKEVY 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412  203 AIKSKEIQNVLAQYDSNLCPASIDEFYMNLTSHLRLQELAFTVENitmvveKIRKQVHEETGVTVSCGIAANKLLAKIAS 282
Cdd:PRK01216  82 QQVSNRIMKLLREYSEKIEIASIDEAYLDISDKVKNYQDAYNLGL------EIKNKILEKEKITVTVGISKNKVFAKIAA 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412  283 NKRKPNNQFFIPFDEIGisKFMNDLPVREVSGIGRVLEQQLLGLEIKTCGDIQRNLVILSYIFLPKSFQNLLrcsYGFGT 362
Cdd:PRK01216 156 DMAKPNGIKVIDDEEVK--RFINELDIADIPGIGDITAEKLKKLGVNKLVDTLRIEFDELKGIIGEAKAKYL---FSLAR 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412  363 TILDEYGESK-RKTIGSEATFSSNLSSPSIIEYKLRLLVQNVSENLQKRGLVTNSIAIkykTSEFQVHTKQKSIGQFIhS 441
Cdd:PRK01216 231 NEYNEPVRARvRKSIGRYVTLPRNTRDLEEIKPYLKRAIEEAYYKLDGIPKAIHVVAI---MEDLDIVSRGRTFTHGI-S 306

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 63054412  442 ESDLLKPALQLLRQ---SYPMTIRLLGVRATKLVSKS 475
Cdd:PRK01216 307 KETAYREAVRLLQKileEDERKIRRIGVRFSKIIEAI 343
PolY_Pol_iota cd01703
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. ...
 133-470 7.14e-36

DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol iota is thought to be one of the least efficient polymerases, particularly when opposite pyrimidines; it can incorporate the correct nucleotide opposite a purine much more efficiently than opposite a pyrimidine, and prefers to insert guanosine instead of adenosine opposite thymidine. Pol iota is believed to use Hoogsteen rather than Watson-Crick base pairing, which may explain the varying efficiency for different template nucleotides.


Pssm-ID: 176457 [Multi-domain]  Cd Length: 379  Bit Score: 137.99  E-value: 7.14e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412 133 VHVDCDAFYASIEELKNPKLKSLPMAVG-KSVLCTANYVARKFGVRSAMPEFIARKICPDLVVIP-LNLSEYAIKSKEIQ 210
Cdd:cd01703   1 IHLDLDCFYAQVEEIRDPSLKSKPLGIQqKYIVVTCNYEARRLGVKKLMSIKDAKEICPDLVLVNgEDLTPFRDMSKKVY 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412 211 NVLAQYdsnlCPAS------IDEFYMNLTShLRLQeLAftveniTMVVEKIRKQVHEETGVTVSCGIAANKLLAKIASNK 284
Cdd:cd01703  81 RLLRSY----SWNDrverlgFDENFMDVTE-MRLL-VA------SHIAYEMRERIENELGLTCCAGIASNKLLAKLVGSV 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412 285 RKPNNQ--FFIPFDEIGISkFMNDLPVREVSGIGRVLEQQLLGLEIKTCGDIQRNLV-----------ILSYIFLPKSF- 350
Cdd:cd01703 149 NKPNQQttLLPPSCADLMD-FMDLHDLRKIPGIGYKTAAKLEAHGISSVRDLQEFSNrnrqtvgaapsLLELLLMVKEFg 227

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412 351 ----QNLLRCSYGFGTTILDEyGESKRKTIGSEATFsSNLSSPSIIEykLRLLVQNVSENLQKR------------GLVT 414
Cdd:cd01703 228 egigQRIWKLLFGRDTSPVKP-ASDFPQQISIEDSY-KKCSLEEIRE--ARNKIEELLASLLERmkqdlqevkagdGRRP 303

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 63054412 415 NSIAI---KYKTSEFQVH--TKQKSIGQFIHSESD---------LLKPALQLLRQSYPM------TIRLLGVRATK 470
Cdd:cd01703 304 HTLRLtlrRYTSTKKHYNreSKQAPIPSHVFQKLTggneiaarpIEKILMRLFRELVPPknvkgfNLTLLNVCFTN 379
PolY_Pol_eta cd01702
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. ...
 133-470 3.67e-31

DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Unlike other Y-family members, Pol eta can efficiently and accurately replicate DNA past UV-induced lesions. Its activity is initiated by two simultaneous interactions: the PIP box in pol eta interacting with PCNA, and the UBZ (ubiquitin-binding zinc finger) in pol eta interacting with monoubiquitin attached to PCNA. Pol eta is more efficient in copying damaged DNA than undamaged DNA and seems to recognize when a lesion has been passed, facilitating a lesion-dependent dissociation from the DNA.


Pssm-ID: 176456 [Multi-domain]  Cd Length: 359  Bit Score: 123.96  E-value: 3.67e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412 133 VHVDCDAFYASIEELKNPKLKSLPMAVG--KSVLcTANYVARKFGVRSAM--PEfiARKICPDLVVI------------- 195
Cdd:cd01702   1 AHIDMDAFFAQVEQVRLGLLRNDPVAVVqwNSII-AVSYAARAFGVTRFMtiDE--AKKKCPDLILAhvatykkgedead 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412 196 ----------PLNLSEYAIKSKEIQNVLAQYDSNLCPASIDEFYMNLTSHlrlqelaftvenitmVVEKIRKQVHEETGV 265
Cdd:cd01702  78 yhenpsparhKVSLDPYRRASRKILNILKRFGDVVEKASIDEAYLDLGSR---------------IVEEIRQQVYDELGY 142

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412 266 TVSCGIAANKLLAKIASNKRKPNNQFFIPFDEigISKFMNDLPVREVSGIGRVLE---QQLLGLE--------IKTCGDI 334
Cdd:cd01702 143 TCSAGIAHNKMLAKLASGMNKPNAQTILRNDA--VASFLSSLPITSIRGLGGKLGeeiIDLLGLPtegdvagfRSSESDL 220

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412 335 QRNLV--ILSYIFlpksfqNLLRcsygfGTtildEYGESKR----KTIGSEATFSSNLSSPSI-IEYKLRLLVQNVSENL 407
Cdd:cd01702 221 QEHFGekLGEWLY------NLLR-----GI----DHEPVKPrplpKSMGSSKNFPGKTALSTEdVQHWLLVLASELNSRL 285

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 63054412 408 QK----RGLVTNSIAIKYKTSEFQVhTKQKSIG------QFIHSESDLLKPAL--QLLRQSYPMTIRLLGVRATK 470
Cdd:cd01702 286 EDdryeNNRRPKTLVLSLRQRGDGV-RRSRSCAlprydaQKIVKDAFKLIKAIneEGLGLAWNYPLTLLSLSFTK 359
IMS_C pfam11799
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss).
 373-475 2.94e-20

impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss).


Pssm-ID: 463354 [Multi-domain]  Cd Length: 104  Bit Score: 85.69  E-value: 2.94e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412   373 RKTIGSEATFSSNLSSPSIIEYKLRLLVQNVSENLQKRGLVTNSIAIKYKTSEFQVHTKQKSIGQFIHSESDLLKPALQL 452
Cdd:pfam11799   1 RKSIGAERTFGRDLTDLEELREALLELAEELAERLRRQGLVARTVTVKIRYSDFRTITRSVTLPSPTDDTDEIYRAALRL 80

                          90       100
                  ....*....|....*....|....
gi 63054412   453 LRQSYPMT-IRLLGVRATKLVSKS 475
Cdd:pfam11799  81 LRRLYRGRpVRLLGVSLSNLVPEG 104
umuC PRK03609
translesion error-prone DNA polymerase V subunit UmuC;
134-336 2.21e-13

translesion error-prone DNA polymerase V subunit UmuC;


Pssm-ID: 179607 [Multi-domain]  Cd Length: 422  Bit Score: 72.11  E-value: 2.21e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412  134 HVDCDAFYASIEELKNPKLKSLPMAV-----GKSVLCTANyvARKFGVRSAMPEFIARKIC--PDLVVIPLNLSEYAIKS 206
Cdd:PRK03609   4 LCDVNSFYASCETVFRPDLRGKPVVVlsnndGCVIARSAE--AKALGIKMGDPWFKQKDLFrrCGVVCFSSNYELYADMS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412  207 KEIQNVLAQYDSNLCPASIDEFYMNLTShlrlqelaftVEN---ITMVVEKIRKQVHEETGVTVSCGIAANKLLAKIASN 283
Cdd:PRK03609  82 NRVMSTLEELSPRVEIYSIDEAFCDLTG----------VRNcrdLTDFGREIRATVLQRTHLTVGVGIAQTKTLAKLANH 151

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 63054412  284 KRKP-NNQFFIPFDEIGIS---KFMNDLPVREVSGIGRVLEQQLLGLEIKTCGDIQR 336
Cdd:PRK03609 152 AAKKwQRQTGGVVDLSNLErqrKLLSLQPVEEVWGVGRRISKKLNAMGIKTALDLAD 208
PolY_like cd03468
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that ...
 163-455 3.79e-10

DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.


Pssm-ID: 176458 [Multi-domain]  Cd Length: 335  Bit Score: 61.63  E-value: 3.79e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412 163 VLCTANYVARKFGVRSAMPEFIARKICPDLVVIPLNLSEYAIKSKEIQNVLAQYDSNLCPASIDEFYMNLTSHLRLqela 242
Cdd:cd03468  35 RILACNAAARAAGVRPGMPLAEALALCPNLQVVEYDPEADARALQELALWLLRFTPLVALDGPDGLLLDVTGCLHL---- 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412 243 FTVEnITMvVEKIRkQVHEETGVTVSCGIAANKLLAKIASNKRKPNNQFFIPFDEIGISkFMNDLPVREVsGIGRVLEQQ 322
Cdd:cd03468 111 FGGE-DAL-AASLR-AALATLGLSARAGIADTPGAAWLLARAGGGRGVLRREALAAALV-LLAPLPVAAL-RLPPETVEL 185

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054412 323 LLGLEIKTCGDIQRN-LVILSYIFlPKSFQNLLRCSYGFGTTILDEYGESKRKTIGSEATFSSNLSSPSiiEYKLRLLVQ 401
Cdd:cd03468 186 LARLGLRTLGDLAALpRAELARRF-GLALLLRLDQAYGRDPEPLLFSPPPPAFDFRLELQLEEPIARGL--LFPLRRLLE 262

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 63054412 402 NVSENLQKRGLVTNSIAIKYktsEFQVHTKQKSIGQFIHSESDLLkPALQLLRQ 455
Cdd:cd03468 263 QLCAFLALRGLGARRLSLTL---FREDGRVTRVLVGLARPSRDDL-PLLRLLRE 312
IMS_HHH pfam11798
IMS family HHH motif; These proteins are involved in UV protection, eg.
 300-328 6.27e-03

IMS family HHH motif; These proteins are involved in UV protection, eg.


Pssm-ID: 432081 [Multi-domain]  Cd Length: 32  Bit Score: 34.30  E-value: 6.27e-03
                          10        20
                  ....*....|....*....|....*....
gi 63054412   300 ISKFMNDLPVREVSGIGRVLEQQLLGLEI 328
Cdd:pfam11798   4 VPEFLWPLPISKIPGIGKKLAEKLKALGI 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH