NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|19075376|ref|NP_587876|]
View 

tyrosine--tRNA (Tyr) ligase Yrs1 [Schizosaccharomyces pombe]

Protein Classification

nucleotidyl transferase family protein( domain architecture ID 117)

nucleotidyl transferase (NT) family protein contains a conserved dinucleotide-binding domain; the NT superfamily includes the class I amino-acyl tRNA synthetases, pantothenate synthetase (PanC), ATP sulfurylase, and cytidylyltransferases

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
nt_trans super family cl00015
nucleotidyl transferase superfamily; nt_trans (nucleotidyl transferase) This superfamily ...
 6-338 1.79e-106

nucleotidyl transferase superfamily; nt_trans (nucleotidyl transferase) This superfamily includes the class I amino-acyl tRNA synthetases, pantothenate synthetase (PanC), ATP sulfurylase, and the cytidylyltransferases, all of which have a conserved dinucleotide-binding domain.


The actual alignment was detected with superfamily member PRK08560:

Pssm-ID: 469580 [Multi-domain]  Cd Length: 329  Bit Score: 316.81  E-value: 1.79e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075376    6 DEKYELITRNLQEVLGAKMIREILNERD-ISLYWGSAPTGRPHCGYFVPMMKLADFLKAGVHVTVLLADVHAFLDNmKAP 84
Cdd:PRK08560   2 EERLELITRNTEEVVTEEELRELLESKEePKAYIGFEPSGKIHLGHLLTMNKLADLQKAGFKVTVLLADWHAYLND-KGD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075376   85 MELVQHRVRYYeiivKSILKSLNIPIEKLRFVIGSSYQLKEDYTLDNFRLAASTTEHTARRAGAEVVKQVASPLLSSLIY 164
Cdd:PRK08560  81 LEEIRKVAEYN----KKVFEALGLDPDKTEFVLGSEFQLDKEYWLLVLKLAKNTTLARARRSMTIMGRRMEEPDVSKLVY 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075376  165 PGMQALDEQYLGVDVQFGGVDQRKIFVMAEEVLPVLGYKKRGHLMNPMVPSLAGG--KMSSSAAANAkIDILDDPKTVNK 242
Cdd:PRK08560 157 PLMQVADIFYLDVDIAVGGMDQRKIHMLAREVLPKLGYKKPVCIHTPLLTGLDGGgiKMSKSKPGSA-IFVHDSPEEIRR 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075376  243 KIRSAFCEPGVVEENGCLAFLKYVSFPAMElrgetEFVIDRPEQFGGRMVFKTYEEVEKAYKDLTLSPQDLKLGLESSVN 322
Cdd:PRK08560 236 KIKKAYCPPGEVEGNPVLEIAKYHIFPRYD-----PFVIERPEKYGGDLEYESYEELERDYAEGKLHPMDLKNAVAEYLI 310

                        330
                 ....*....|....*.
gi 19075376  323 TLLAGVQEQLKQYPDL 338
Cdd:PRK08560 311 EILEPVREYLEEGPEL 326
 
Name Accession Description Interval E-value
PRK08560 PRK08560
tyrosyl-tRNA synthetase; Validated
 6-338 1.79e-106

tyrosyl-tRNA synthetase; Validated


Pssm-ID: 236286 [Multi-domain]  Cd Length: 329  Bit Score: 316.81  E-value: 1.79e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075376    6 DEKYELITRNLQEVLGAKMIREILNERD-ISLYWGSAPTGRPHCGYFVPMMKLADFLKAGVHVTVLLADVHAFLDNmKAP 84
Cdd:PRK08560   2 EERLELITRNTEEVVTEEELRELLESKEePKAYIGFEPSGKIHLGHLLTMNKLADLQKAGFKVTVLLADWHAYLND-KGD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075376   85 MELVQHRVRYYeiivKSILKSLNIPIEKLRFVIGSSYQLKEDYTLDNFRLAASTTEHTARRAGAEVVKQVASPLLSSLIY 164
Cdd:PRK08560  81 LEEIRKVAEYN----KKVFEALGLDPDKTEFVLGSEFQLDKEYWLLVLKLAKNTTLARARRSMTIMGRRMEEPDVSKLVY 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075376  165 PGMQALDEQYLGVDVQFGGVDQRKIFVMAEEVLPVLGYKKRGHLMNPMVPSLAGG--KMSSSAAANAkIDILDDPKTVNK 242
Cdd:PRK08560 157 PLMQVADIFYLDVDIAVGGMDQRKIHMLAREVLPKLGYKKPVCIHTPLLTGLDGGgiKMSKSKPGSA-IFVHDSPEEIRR 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075376  243 KIRSAFCEPGVVEENGCLAFLKYVSFPAMElrgetEFVIDRPEQFGGRMVFKTYEEVEKAYKDLTLSPQDLKLGLESSVN 322
Cdd:PRK08560 236 KIKKAYCPPGEVEGNPVLEIAKYHIFPRYD-----PFVIERPEKYGGDLEYESYEELERDYAEGKLHPMDLKNAVAEYLI 310

                        330
                 ....*....|....*.
gi 19075376  323 TLLAGVQEQLKQYPDL 338
Cdd:PRK08560 311 EILEPVREYLEEGPEL 326
TyrRS_core cd00805
catalytic core domain of tyrosinyl-tRNA synthetase; Tyrosinyl-tRNA synthetase (TyrRS) ...
 34-324 9.25e-99

catalytic core domain of tyrosinyl-tRNA synthetase; Tyrosinyl-tRNA synthetase (TyrRS) catalytic core domain. TyrRS is a homodimer which attaches Tyr to the appropriate tRNA. TyrRS is a class I tRNA synthetases, so it aminoacylates the 2'-OH of the nucleotide at the 3' end of the tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formationof the enzyme bound aminoacyl-adenylate. It contains the class I characteristic HIGH and KMSKS motifs, which are involved in ATP binding.


Pssm-ID: 173902 [Multi-domain]  Cd Length: 269  Bit Score: 294.90  E-value: 9.25e-99
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075376  34 ISLYWGSAPTG-RPHCGYFVPMMKLADFLKAGVHVTVLLADVHAFLDNMK--------APMELVQHRVRYYEIIVKSILK 104
Cdd:cd00805   1 LKVYIGFDPTApSLHLGHLVPLMKLRDFQQAGHEVIVLIGDATAMIGDPSgkseerklLDLELIRENAKYYKKQLKAILD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075376 105 slNIPIEKLRFVIGSSYQLKeDYTLDNFRLAASTTEHTARRAGAEVVKQ--VASPLLSSLIYPGMQALDEQYLGVDVQFG 182
Cdd:cd00805  81 --FIPPEKAKFVNNSDWLLS-LYTLDFLRLGKHFTVNRMLRRDAVKVRLeeEEGISFSEFIYPLLQAYDFVYLDVDLQLG 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075376 183 GVDQRKIFVMAEEVLPVLGYKKRGHLMNPMVPSLAGGKMSSSAAANAKIDILDDPKTVNKKIRSAFCEPgvveengCLAF 262
Cdd:cd00805 158 GSDQRGNITLGRDLIRKLGYKKVVGLTTPLLTGLDGGKMSKSEGNAIWDPVLDSPYDVYQKIRNAFDPD-------VLEF 230

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19075376 263 LKYVSFPamelrgetefvidrpeqfggrmVFKTYEEVEKAYKDLtLSPQDLKLGLESSVNTL 324
Cdd:cd00805 231 LKLFTFL----------------------DYEEIEELEEEHAEG-PLPRDAKKALAEELTKL 269
tRNA-synt_1b pfam00579
tRNA synthetases class I (W and Y);
29-326 3.02e-85

tRNA synthetases class I (W and Y);


Pssm-ID: 395461 [Multi-domain]  Cd Length: 292  Bit Score: 261.44  E-value: 3.02e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075376    29 LNERDISLYWGSAPTGRPHCGYFVPMMKLADFLKAGVHVTVLLADVHAFL-DNMKAPMELVQHRVRYYEIIVKSILKsLN 107
Cdd:pfam00579   1 KKNRPLRVYSGIDPTGPLHLGYLVPLMKLRQFQQAGHEVFFLIGDLHAIIgDPSKSPERKLLSRETVLENAIKAQLA-CG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075376   108 IPIEKLRFVIGSSYQLKEDYTLDNFRLAASTTEHTARRAGaEVVKQVASP---LLSSLIYPGMQALDEQYLGVDVQFGGV 184
Cdd:pfam00579  80 LDPEKAEIVNNSDWLEHLELAWLLRDLGKHFSLNRMLQFK-DVKKRLEQGpgiSLGEFTYPLLQAYDILLLKADLQPGGS 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075376   185 DQRKIFVMAEEVLPVLGYK---KRGHLMNPMVPSLAGGKMSSSAAANAKIDILDDPKTVNKKIRSAFCEPGvvEENGCLA 261
Cdd:pfam00579 159 DQWGNIELGRDLARRFNKKifkKPVGLTNPLLTGLDGGKKMSKSAGNSAIFLDDDPESVYKKIQKAYTDPD--REVRKDL 236

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19075376   262 FLKYVSFPamelrgeteFVIDRPEQFGGRMVFKTYEEVEKAYKDLTLSPQDLKLGLESSVNTLLA 326
Cdd:pfam00579 237 KLFTFLSN---------EEIEILEAELGKSPYREAEELLAREVTGLVHGGDLKKAAAEAVNKLLQ 292
tyrS TIGR00234
tyrosyl-tRNA synthetase; This tyrosyl-tRNA synthetase model starts picking up ...
 5-337 8.14e-65

tyrosyl-tRNA synthetase; This tyrosyl-tRNA synthetase model starts picking up tryptophanyl-tRNA synthetases at scores of 0 and below. The proteins found by this model have a deep split between two groups. One group contains bacterial and organellar eukaryotic examples. The other contains archaeal and cytosolic eukaryotic examples. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 272976 [Multi-domain]  Cd Length: 378  Bit Score: 211.49  E-value: 8.14e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075376     5 PDEKYELITRNLQEVLGAKMIREILN--ERDISLYWGSAPTG-RPHCGYFVPMMKLADFLKAGVHVTVLLADVHAFLDNM 81
Cdd:TIGR00234   1 MNNILLLLTKRGLEVQTPEEEKDLLKllERPLKLYLGFDPTApSLHLGHLVPLLKLRDFQQAGHEVIVLLGDFTALIGDP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075376    82 KAPMELVQ-----HRVRYYEIIVKSILKSLNIpiEKLRFVIGSSYQLKEDYTLDNFRLAASTTEHTARRAGAEVVKQVAS 156
Cdd:TIGR00234  81 TGKSEVRKiltreEVQENAENIKKQIARFLDF--EKAKFVYNSEWLLKLNYTDFIRLLGKIFTVNRMLRRDAFSSRFEEN 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075376   157 PLLSSLIYPGMQALDEQYLGVDVQFGGVDQ----RKIFVMAEEVLPVLGYKKRGHLMNP---MVPSL-AGGKMSSSAAAN 228
Cdd:TIGR00234 159 ISLHEFIYPLLQAYDFVYLNVDLQLGGSDQwfniRKGRDLARENLPSLQFGLTVPLLTPadgEKMGKsLGGAVSLDEGKY 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075376   229 A-KIDILDDPKTVNKKIRSAFCEPGV----------------VEENGCLAFLKYVSFPAMELRGET-------------E 278
Cdd:TIGR00234 239 DfYQKVINTPDELVKKYLKLFTFLGLeeieqlvelkgpnpreVKENLALEITKYVHGPEAALAAEEiseaifsgglnpdE 318

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 19075376   279 FVIDRPEQFGGRMVFKTYEEVEKAYKDLTLSPQDLKLGlESSVNTLLAGVQEQLKQYPD 337
Cdd:TIGR00234 319 VPIFRPEKFGGPITLADLLVLSGLFPSKSEARRDIKNG-GVYINGEKVEDLEPIRKELE 376
TrpS COG0180
Tryptophanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; ...
 188-344 3.43e-07

Tryptophanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Tryptophanyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439950 [Multi-domain]  Cd Length: 330  Bit Score: 51.59  E-value: 3.43e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075376 188 KIFVMAEEVLPvlgykKRGhlmnPMVPSLAG-GKMSSSAAaNAkIDILDDPKTVNKKIRSAFCEPGVVEengclaflkyv 266
Cdd:COG0180 171 EVFPEPEALIP-----EEG----ARIPGLDGrKKMSKSYG-NT-INLLDDPKEIRKKIKSAVTDSERLR----------- 228

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075376 267 sfpamelrgetefvIDRPEQFGGRMVFKTY---------EEVEKAYKDLTLSPQDLKLGLESSVNTLLAGVQEQLKQY-- 335
Cdd:COG0180 229 --------------YDDPGKPEVCNLFTIYsafsgkeevEELEAEYRAGGIGYGDLKKALAEAVVEFLAPIRERRAELla 294

                       170
                ....*....|.
gi 19075376 336 --PDLDSILKA 344
Cdd:COG0180 295 dpAELDEILAE 305
 
Name Accession Description Interval E-value
PRK08560 PRK08560
tyrosyl-tRNA synthetase; Validated
 6-338 1.79e-106

tyrosyl-tRNA synthetase; Validated


Pssm-ID: 236286 [Multi-domain]  Cd Length: 329  Bit Score: 316.81  E-value: 1.79e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075376    6 DEKYELITRNLQEVLGAKMIREILNERD-ISLYWGSAPTGRPHCGYFVPMMKLADFLKAGVHVTVLLADVHAFLDNmKAP 84
Cdd:PRK08560   2 EERLELITRNTEEVVTEEELRELLESKEePKAYIGFEPSGKIHLGHLLTMNKLADLQKAGFKVTVLLADWHAYLND-KGD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075376   85 MELVQHRVRYYeiivKSILKSLNIPIEKLRFVIGSSYQLKEDYTLDNFRLAASTTEHTARRAGAEVVKQVASPLLSSLIY 164
Cdd:PRK08560  81 LEEIRKVAEYN----KKVFEALGLDPDKTEFVLGSEFQLDKEYWLLVLKLAKNTTLARARRSMTIMGRRMEEPDVSKLVY 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075376  165 PGMQALDEQYLGVDVQFGGVDQRKIFVMAEEVLPVLGYKKRGHLMNPMVPSLAGG--KMSSSAAANAkIDILDDPKTVNK 242
Cdd:PRK08560 157 PLMQVADIFYLDVDIAVGGMDQRKIHMLAREVLPKLGYKKPVCIHTPLLTGLDGGgiKMSKSKPGSA-IFVHDSPEEIRR 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075376  243 KIRSAFCEPGVVEENGCLAFLKYVSFPAMElrgetEFVIDRPEQFGGRMVFKTYEEVEKAYKDLTLSPQDLKLGLESSVN 322
Cdd:PRK08560 236 KIKKAYCPPGEVEGNPVLEIAKYHIFPRYD-----PFVIERPEKYGGDLEYESYEELERDYAEGKLHPMDLKNAVAEYLI 310

                        330
                 ....*....|....*.
gi 19075376  323 TLLAGVQEQLKQYPDL 338
Cdd:PRK08560 311 EILEPVREYLEEGPEL 326
TyrRS_core cd00805
catalytic core domain of tyrosinyl-tRNA synthetase; Tyrosinyl-tRNA synthetase (TyrRS) ...
 34-324 9.25e-99

catalytic core domain of tyrosinyl-tRNA synthetase; Tyrosinyl-tRNA synthetase (TyrRS) catalytic core domain. TyrRS is a homodimer which attaches Tyr to the appropriate tRNA. TyrRS is a class I tRNA synthetases, so it aminoacylates the 2'-OH of the nucleotide at the 3' end of the tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formationof the enzyme bound aminoacyl-adenylate. It contains the class I characteristic HIGH and KMSKS motifs, which are involved in ATP binding.


Pssm-ID: 173902 [Multi-domain]  Cd Length: 269  Bit Score: 294.90  E-value: 9.25e-99
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075376  34 ISLYWGSAPTG-RPHCGYFVPMMKLADFLKAGVHVTVLLADVHAFLDNMK--------APMELVQHRVRYYEIIVKSILK 104
Cdd:cd00805   1 LKVYIGFDPTApSLHLGHLVPLMKLRDFQQAGHEVIVLIGDATAMIGDPSgkseerklLDLELIRENAKYYKKQLKAILD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075376 105 slNIPIEKLRFVIGSSYQLKeDYTLDNFRLAASTTEHTARRAGAEVVKQ--VASPLLSSLIYPGMQALDEQYLGVDVQFG 182
Cdd:cd00805  81 --FIPPEKAKFVNNSDWLLS-LYTLDFLRLGKHFTVNRMLRRDAVKVRLeeEEGISFSEFIYPLLQAYDFVYLDVDLQLG 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075376 183 GVDQRKIFVMAEEVLPVLGYKKRGHLMNPMVPSLAGGKMSSSAAANAKIDILDDPKTVNKKIRSAFCEPgvveengCLAF 262
Cdd:cd00805 158 GSDQRGNITLGRDLIRKLGYKKVVGLTTPLLTGLDGGKMSKSEGNAIWDPVLDSPYDVYQKIRNAFDPD-------VLEF 230

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19075376 263 LKYVSFPamelrgetefvidrpeqfggrmVFKTYEEVEKAYKDLtLSPQDLKLGLESSVNTL 324
Cdd:cd00805 231 LKLFTFL----------------------DYEEIEELEEEHAEG-PLPRDAKKALAEELTKL 269
tRNA-synt_1b pfam00579
tRNA synthetases class I (W and Y);
29-326 3.02e-85

tRNA synthetases class I (W and Y);


Pssm-ID: 395461 [Multi-domain]  Cd Length: 292  Bit Score: 261.44  E-value: 3.02e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075376    29 LNERDISLYWGSAPTGRPHCGYFVPMMKLADFLKAGVHVTVLLADVHAFL-DNMKAPMELVQHRVRYYEIIVKSILKsLN 107
Cdd:pfam00579   1 KKNRPLRVYSGIDPTGPLHLGYLVPLMKLRQFQQAGHEVFFLIGDLHAIIgDPSKSPERKLLSRETVLENAIKAQLA-CG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075376   108 IPIEKLRFVIGSSYQLKEDYTLDNFRLAASTTEHTARRAGaEVVKQVASP---LLSSLIYPGMQALDEQYLGVDVQFGGV 184
Cdd:pfam00579  80 LDPEKAEIVNNSDWLEHLELAWLLRDLGKHFSLNRMLQFK-DVKKRLEQGpgiSLGEFTYPLLQAYDILLLKADLQPGGS 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075376   185 DQRKIFVMAEEVLPVLGYK---KRGHLMNPMVPSLAGGKMSSSAAANAKIDILDDPKTVNKKIRSAFCEPGvvEENGCLA 261
Cdd:pfam00579 159 DQWGNIELGRDLARRFNKKifkKPVGLTNPLLTGLDGGKKMSKSAGNSAIFLDDDPESVYKKIQKAYTDPD--REVRKDL 236

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19075376   262 FLKYVSFPamelrgeteFVIDRPEQFGGRMVFKTYEEVEKAYKDLTLSPQDLKLGLESSVNTLLA 326
Cdd:pfam00579 237 KLFTFLSN---------EEIEILEAELGKSPYREAEELLAREVTGLVHGGDLKKAAAEAVNKLLQ 292
tyrS TIGR00234
tyrosyl-tRNA synthetase; This tyrosyl-tRNA synthetase model starts picking up ...
 5-337 8.14e-65

tyrosyl-tRNA synthetase; This tyrosyl-tRNA synthetase model starts picking up tryptophanyl-tRNA synthetases at scores of 0 and below. The proteins found by this model have a deep split between two groups. One group contains bacterial and organellar eukaryotic examples. The other contains archaeal and cytosolic eukaryotic examples. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 272976 [Multi-domain]  Cd Length: 378  Bit Score: 211.49  E-value: 8.14e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075376     5 PDEKYELITRNLQEVLGAKMIREILN--ERDISLYWGSAPTG-RPHCGYFVPMMKLADFLKAGVHVTVLLADVHAFLDNM 81
Cdd:TIGR00234   1 MNNILLLLTKRGLEVQTPEEEKDLLKllERPLKLYLGFDPTApSLHLGHLVPLLKLRDFQQAGHEVIVLLGDFTALIGDP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075376    82 KAPMELVQ-----HRVRYYEIIVKSILKSLNIpiEKLRFVIGSSYQLKEDYTLDNFRLAASTTEHTARRAGAEVVKQVAS 156
Cdd:TIGR00234  81 TGKSEVRKiltreEVQENAENIKKQIARFLDF--EKAKFVYNSEWLLKLNYTDFIRLLGKIFTVNRMLRRDAFSSRFEEN 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075376   157 PLLSSLIYPGMQALDEQYLGVDVQFGGVDQ----RKIFVMAEEVLPVLGYKKRGHLMNP---MVPSL-AGGKMSSSAAAN 228
Cdd:TIGR00234 159 ISLHEFIYPLLQAYDFVYLNVDLQLGGSDQwfniRKGRDLARENLPSLQFGLTVPLLTPadgEKMGKsLGGAVSLDEGKY 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075376   229 A-KIDILDDPKTVNKKIRSAFCEPGV----------------VEENGCLAFLKYVSFPAMELRGET-------------E 278
Cdd:TIGR00234 239 DfYQKVINTPDELVKKYLKLFTFLGLeeieqlvelkgpnpreVKENLALEITKYVHGPEAALAAEEiseaifsgglnpdE 318

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 19075376   279 FVIDRPEQFGGRMVFKTYEEVEKAYKDLTLSPQDLKLGlESSVNTLLAGVQEQLKQYPD 337
Cdd:TIGR00234 319 VPIFRPEKFGGPITLADLLVLSGLFPSKSEARRDIKNG-GVYINGEKVEDLEPIRKELE 376
PTZ00126 PTZ00126
tyrosyl-tRNA synthetase; Provisional
 1-343 1.03e-39

tyrosyl-tRNA synthetase; Provisional


Pssm-ID: 240282 [Multi-domain]  Cd Length: 383  Bit Score: 145.60  E-value: 1.03e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075376    1 MSLTPDEKYELITRNLQEVLGAKMIREILNERDISL-YWGSAPTGRPHCGY-FVPMMKLADFLKAGVHVTVLLADVHAFL 78
Cdd:PTZ00126  33 SKLSLEERVKLCLSIGEECIQPEELRELLKLKERPIcYDGFEPSGRMHIAQgILKAINVNKLTKAGCVFVFWVADWFALL 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075376   79 DN-MKAPMELVQHRVRYYeiivKSILKSLNIPIEKLRFVIGSSYQLK--EDYTLDNFRLAASTTEHTARRAG-----AEV 150
Cdd:PTZ00126 113 NNkMGGDLEKIRKVGEYF----IEVWKAAGMDMDNVRFLWASEEINKnpNDYWLRVMDIARSFNITRIKRCSqimgrSEG 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075376  151 VKQVASPLLssliYPGMQALDEQYLGVDVQFGGVDQRKIFVMAEEVLPVLGYKKRGH-LMNPMVPSLAGG--KMSSSAAa 227
Cdd:PTZ00126 189 DEQPCAQIL----YPCMQCADIFYLKADICQLGMDQRKVNMLAREYCDKKKIKKKPIiLSHHMLPGLLEGqeKMSKSDP- 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075376  228 NAKIDILDDPKTVNKKIRSAFCEPGVVEENGCLAFLKYVSFPAMelrgeTEFVIDRPEQFGGRMVFKTYEEVEKAYKDLT 307
Cdd:PTZ00126 264 NSAIFMEDSEEDVNRKIKKAYCPPGVIEGNPILAYFKSIVFPAF-----NSFTVLRKEKNGGDVTYTTYEELEKDYLSGA 338

                        330       340       350
                 ....*....|....*....|....*....|....*.
gi 19075376  308 LSPQDLKLGLESSVNTLLAGVQEQLKQYPDLDSILK 343
Cdd:PTZ00126 339 LHPGDLKPALAKYLNLMLQPVRDHFQNNPEAKSLLS 374
PTZ00348 PTZ00348
tyrosyl-tRNA synthetase; Provisional
 3-344 4.21e-15

tyrosyl-tRNA synthetase; Provisional


Pssm-ID: 173541 [Multi-domain]  Cd Length: 682  Bit Score: 77.25  E-value: 4.21e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075376    3 LTPDEKYELITRNLQEVLGAKMIREILNER-DISLYWGSAPTGRPHC--GYFvPMMKLADFLKAGVHVTVLLADVHAFLd 79
Cdd:PTZ00348   1 MNTDERYKLLRSVGEECIQESELRNLIEKKpLIRCYDGFEPSGRMHIaqGIF-KAVNVNKCTQAGCEFVFWVADWFALM- 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075376   80 NMKAPMELvqHRVRYYEIIVKSILKSLNIPIEKLRFVIGSSYQLKEDYTLDNFRLAASTTEHTAR--RAGAEVVKQVASP 157
Cdd:PTZ00348  79 NDKVGGEL--EKIRIVGRYLIEVWKAAGMDMDKVLFLWSSEEITNHANTYWRTVLDIGRQNTIARikKCCTIMGKTEGTL 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075376  158 LLSSLIYPGMQALDEQYLGVDVQFGGVDQRKIFVMAEEVLPVLGYK-KRGHLMNPMVPSLAGG--KMSSSAAANAkIDIL 234
Cdd:PTZ00348 157 TAAQVLYPLMQCADIFFLKADICQLGLDQRKVNMLAREYCDLIGRKlKPVILSHHMLAGLKQGqaKMSKSDPDSA-IFME 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075376  235 DDPKTVNKKIRSAFCePGVV----------------EENGCLAFLKYVSFPamelRGETEFVIDRPEqfggrmvFKTYEE 298
Cdd:PTZ00348 236 DTEEDVARKIRQAYC-PRVKqsaseitddgapvatdDRNPVLDYFQCVVYA----RPGAVATIDGTT-------YATYED 303

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*.
gi 19075376  299 VEKAYKDLTLSPQDLKLGLESSVNTLLAGVQEQLKQYPDLDSILKA 344
Cdd:PTZ00348 304 LEQAFVSDEVSEEALKSCLIDEVNALLEPVRQHFASNPEAHELLEA 349
PRK12285 PRK12285
tryptophanyl-tRNA synthetase; Reviewed
 30-248 3.24e-12

tryptophanyl-tRNA synthetase; Reviewed


Pssm-ID: 237037 [Multi-domain]  Cd Length: 368  Bit Score: 67.20  E-value: 3.24e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075376   30 NERDISLYWGSAPTGRPHCGYFVPMMKLADFLKAGVHVTVLLADVHAFLDNMKAPMELVQHRVRYyeiiVKSILkSLNIP 109
Cdd:PRK12285  63 NGKPFAVYTGFMPSGPMHIGHKMVFDELKWHQEFGANVYIPIADDEAYAARGLSWEETREWAYEY----ILDLI-ALGFD 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075376  110 IEKLRFvigssYQLKEDYTLDN--FRLAASTTEHTAR----RAGAEVVKQVASPLLSS--LIYPgmQALDE-QYLGVDVq 180
Cdd:PRK12285 138 PDKTEI-----YFQSENIKVYDlaFELAKKVNFSELKaiygFTGETNIGHIFYPATQAadILHP--QLEEGpKPTLVPV- 209

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19075376  181 fgGVDQ-------RKIfvmAEEVLPVLGYKKRGHLMNPMVPSLAGGKMSSSAAANAkIDILDDPKTVNKKIRSAF 248
Cdd:PRK12285 210 --GIDQdphirltRDI---AERLHGGYGFIKPSSTYHKFMPGLTGGKMSSSKPESA-IYLTDDPETVKKKIMKAL 278
trpS TIGR00233
tryptophanyl-tRNA synthetase; This model represents tryptophanyl-tRNA synthetase. Some members ...
 36-346 1.82e-10

tryptophanyl-tRNA synthetase; This model represents tryptophanyl-tRNA synthetase. Some members of the family have a pfam00458 domain amino-terminal to the region described by this model. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 272975 [Multi-domain]  Cd Length: 327  Bit Score: 61.58  E-value: 1.82e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075376    36 LYWGSAPTGRPHCGYFVPMMKLADFLKAGVHVTVLLADVHAFLdnmkAPMELVQHRVRYYEIIVKSILkSLNIPIEKLRF 115
Cdd:TIGR00233   5 VLTGIQPSGKMHLGHYLGAIQTKWLQQFGVELFICIADLHAIT----VKQTDPDALRKAREELAADYL-AVGLDPEKTFI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075376   116 VIGSSYQLKEDYTLdnfRLAASTTEHTARRAGAEVVKQVASPLLSSLI-YPGMQALDEQYLGVDVQFGGVDQRKIFVMAE 194
Cdd:TIGR00233  80 FLQSDYPEHYELAW---LLSCQVTFGELKRMTQFKDKSQAENVPIGLLsYPVLQAADILLYQADLVPVGIDQDQHLELTR 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075376   195 EV-------------LPVLGYKKRGhlmnPMVPSLAGGKMSSSaAANAKIDILDDPKTVNKKIRSAFCEPG--VVEE--- 256
Cdd:TIGR00233 157 DLaerfnkkfknffpKPESLISKFF----PRLMGLSGKKMSKS-DPNSAIFLTDTPKQIKKKIRKAATDGGrvTLFEhre 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075376   257 -----NGCLAFlKYVSFpamelrgeteFVIDRPEqfggrmvfktYEEVEKAYKDLTLSPQDLKLGLESSVNTLLAGVQEQ 331
Cdd:TIGR00233 232 kpgvpNLLVIY-QYLSF----------FLIDDDK----------LKEIYEAYKSGKLGYGECKKALIEVLQEFLKEIQER 290

                         330
                  ....*....|....*..
gi 19075376   332 LKQY--PDLDSILKAAY 346
Cdd:TIGR00233 291 RAEIaeEILDKILEPGA 307
TrpS COG0180
Tryptophanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; ...
 188-344 3.43e-07

Tryptophanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Tryptophanyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439950 [Multi-domain]  Cd Length: 330  Bit Score: 51.59  E-value: 3.43e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075376 188 KIFVMAEEVLPvlgykKRGhlmnPMVPSLAG-GKMSSSAAaNAkIDILDDPKTVNKKIRSAFCEPGVVEengclaflkyv 266
Cdd:COG0180 171 EVFPEPEALIP-----EEG----ARIPGLDGrKKMSKSYG-NT-INLLDDPKEIRKKIKSAVTDSERLR----------- 228

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075376 267 sfpamelrgetefvIDRPEQFGGRMVFKTY---------EEVEKAYKDLTLSPQDLKLGLESSVNTLLAGVQEQLKQY-- 335
Cdd:COG0180 229 --------------YDDPGKPEVCNLFTIYsafsgkeevEELEAEYRAGGIGYGDLKKALAEAVVEFLAPIRERRAELla 294

                       170
                ....*....|.
gi 19075376 336 --PDLDSILKA 344
Cdd:COG0180 295 dpAELDEILAE 305
TyrS COG0162
Tyrosyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Tyrosyl-tRNA ...
 10-239 1.99e-06

Tyrosyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Tyrosyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439932 [Multi-domain]  Cd Length: 409  Bit Score: 49.65  E-value: 1.99e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075376  10 ELITRNLQEVLGAKMIREILNERDISLYWGSAPTGrP--HCGYFVPMMKLADFLKAGVHVTVLLADVHA------FLDNM 81
Cdd:COG0162   6 ELIWRGLIEQITDEELREKLAGGPLTIYLGFDPTA-PslHLGHLVPLMKLRRFQDLGHRPIALIGGFTGmigdpsGKSEE 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075376  82 KAPM--ELVQHRVRYYEIIVKSIL----------------KSLNIpIEKLRFvIGSSYQL-----KEDYTLdnfRLAA-- 136
Cdd:COG0162  85 RKLLteEQVAENAETIKEQVFKFLdfddnkaeivnnsdwlGKLSF-IDFLRD-LGKHFTVnrmleRDDVKK---RLESgq 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075376 137 --STTEhtarragaevvkqvaspllssLIYPGMQALDEQYL----GVDVQFGGVDQRkiF--VMAEEvlpvLGYKKRGH- 207
Cdd:COG0162 160 giSFTE---------------------FSYPLLQGYDFVELyrryGCDLQLGGSDQW--GniLAGRE----LQRRYGGEp 212

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 19075376 208 ---LMNPMVPSLAGGKMSSSaAANAkidI-LDDPKT 239
Cdd:COG0162 213 qfgLTMPLLTGADGTKMGKS-EGNA---IwLDEEKT 244
PRK00927 PRK00927
tryptophanyl-tRNA synthetase; Reviewed
 213-344 2.10e-06

tryptophanyl-tRNA synthetase; Reviewed


Pssm-ID: 234866 [Multi-domain]  Cd Length: 333  Bit Score: 49.32  E-value: 2.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075376  213 VPSLAGG--KMS-SSAAANAKIDILDDPKTVNKKIRSAFCEPGVVEENgclaflkyvsfpamelrgetefVIDRPEQFGG 289
Cdd:PRK00927 184 VMGLDGPtkKMSkSDPNDNNTINLLDDPKTIAKKIKKAVTDSERLREI----------------------RYDLPNKPEV 241

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 19075376  290 RMVF--------KTYEEVEKAYKDLTLSPQDLKLGLESSVNTLLAGVQEQLKQY---PD-LDSILKA 344
Cdd:PRK00927 242 SNLLtiysalsgESIEELEAEYEAGGKGYGDFKKDLAEAVVEFLAPIRERYEELladPAyLDEILAE 308
PLN02486 PLN02486
aminoacyl-tRNA ligase
 184-248 4.18e-04

aminoacyl-tRNA ligase


Pssm-ID: 178104  Cd Length: 383  Bit Score: 42.04  E-value: 4.18e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19075376  184 VDQRKIFVMAEEVLPVLGYKKRGHLMNPMVPSLAG--GKMSSSaAANAKIDILDDPKTVNKKI-RSAF 248
Cdd:PLN02486 227 IDQDPYFRMTRDVAPRLGYYKPALIESRFFPALQGesGKMSAS-DPNSAIYVTDTPKEIKNKInKYAF 293
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH