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Conserved domains on  [gi|19075563|ref|NP_588063|]
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Clr6 and Rpd3L histone deacetylase complex LCCL domain subunit Rxt3 [Schizosaccharomyces pombe]

Protein Classification

LCCL domain-containing protein( domain architecture ID 11577)

LCCL domain-containing protein similar to Schizosaccharomyces pombe transcriptional regulatory protein RXT3, a component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4)

PubMed:  10971586

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LCCL super family cl02694
LCCL domain;
234-300 2.65e-18

LCCL domain;


The actual alignment was detected with superfamily member pfam08642:

Pssm-ID: 445888 [Multi-domain]  Cd Length: 113  Bit Score: 79.59  E-value: 2.65e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075563   234 NPRLCRREIWGTDVYTDDSDIATILAHCGCF-----------------------SLLKPVRKIAV---------VDLYIL 281
Cdd:pfam08642  15 EEITARRELWGTDIYTDDSDVLAALIHSGWIdvdvsalkragnnnkidlsawnpLLTKPPPRTPVnvpidfdlhVTLLIL 94

                          90
                  ....*....|....*....
gi 19075563   282 PPLVHYKGTRKNQIESRSW 300
Cdd:pfam08642  95 PPLEKYASSTRNGIKSREW 113
 
Name Accession Description Interval E-value
Rxt3 pfam08642
Histone deacetylation protein Rxt3; Rxt3 has been shown in yeast to be required for histone ...
 234-300 2.65e-18

Histone deacetylation protein Rxt3; Rxt3 has been shown in yeast to be required for histone deacetylation.


Pssm-ID: 430125 [Multi-domain]  Cd Length: 113  Bit Score: 79.59  E-value: 2.65e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075563   234 NPRLCRREIWGTDVYTDDSDIATILAHCGCF-----------------------SLLKPVRKIAV---------VDLYIL 281
Cdd:pfam08642  15 EEITARRELWGTDIYTDDSDVLAALIHSGWIdvdvsalkragnnnkidlsawnpLLTKPPPRTPVnvpidfdlhVTLLIL 94

                          90
                  ....*....|....*....
gi 19075563   282 PPLVHYKGTRKNQIESRSW 300
Cdd:pfam08642  95 PPLEKYASSTRNGIKSREW 113
 
Name Accession Description Interval E-value
Rxt3 pfam08642
Histone deacetylation protein Rxt3; Rxt3 has been shown in yeast to be required for histone ...
 234-300 2.65e-18

Histone deacetylation protein Rxt3; Rxt3 has been shown in yeast to be required for histone deacetylation.


Pssm-ID: 430125 [Multi-domain]  Cd Length: 113  Bit Score: 79.59  E-value: 2.65e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075563   234 NPRLCRREIWGTDVYTDDSDIATILAHCGCF-----------------------SLLKPVRKIAV---------VDLYIL 281
Cdd:pfam08642  15 EEITARRELWGTDIYTDDSDVLAALIHSGWIdvdvsalkragnnnkidlsawnpLLTKPPPRTPVnvpidfdlhVTLLIL 94

                          90
                  ....*....|....*....
gi 19075563   282 PPLVHYKGTRKNQIESRSW 300
Cdd:pfam08642  95 PPLEKYASSTRNGIKSREW 113
LCCL pfam03815
LCCL domain;
235-302 7.19e-06

LCCL domain;


Pssm-ID: 427521  Cd Length: 96  Bit Score: 44.19  E-value: 7.19e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19075563   235 PRLCRRE---IWGTDVYTDDSDIAT-------ILAHCGCfsllkpvrkiavVDLYILPPLVHYKGTRKNQIESRSWSS 302
Cdd:pfam03815  26 PANCADEkasVYGTDVYSSDSSICKaaihagvIDNSGGL------------VVVRIVGGQNEYTGSTQNGIESLSLSS 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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