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Conserved domains on  [gi|19075849|ref|NP_588349|]
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ribosomal protein lysine methyltransferase Set11 [Schizosaccharomyces pombe]

Protein Classification

SET domain-containing protein( domain architecture ID 1562517)

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain-containing protein may function as a protein-lysine N-methyltransferase, catalyzing the S-adenosyl-L-methionine (SAM)-dependent methylation at specific lysine residues of target proteins such as histones

CATH:  2.170.270.10
EC:  2.1.1.-
Gene Ontology:  GO:0005515|GO:0008168|GO:1904047
PubMed:  12372294|17013555|16086857

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
SET super family cl40432
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ...
 21-239 7.78e-52

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site.


The actual alignment was detected with superfamily member cd19177:

Pssm-ID: 394802 [Multi-domain]  Cd Length: 245  Bit Score: 172.87  E-value: 7.78e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075849  21 VHPSLEFSVIPDAGSCVLANNDINENTVLLKLPPNILINKRTCSRY-------SFRDKLTSFQFLS-WLISEDVHSnlEI 92
Cdd:cd19177   1 KSSKLKPAEFPDTGRGLVATKDIKPGELIISIPESLLINTTTVLSSllgslikRVKPKLSSLQLLAlFLALEKRRG--EN 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075849  93 SPY--YTKALPQGFSFHPVTLTSDHPLWsiLPDEVRNSLLERKNVMAF----DYEQVKKFVSVDQPT----------FQW 156
Cdd:cd19177  79 SFWapYLDSLPKSFDTHPLYWSLEELSL--LPPSLLEAVRKLLDKQKKrfesDWEIISSVLKSLPSLfdseiftleeFRW 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075849 157 GWLCVNTRCLYYD----TGSKNTEDHLTLAPIFEYFNHSPEAQTALI--NTRGTITIKSTRRIDKGEQIFLCYGPHGNDK 230
Cdd:cd19177 157 AWLCVNTRCVYYKlplsDYLSSSEDNIALAPFLDLLNHSPDVNVKAGfnKSGKCYEIRTGTDYKKGEEVFISYGPHSNDF 236


                ....*....
gi 19075849 231 LFTEYGFCL 239
Cdd:cd19177 237 LLLEYGFVL 245
 
Name Accession Description Interval E-value
SET_SETD4 cd19177
SET domain found in SET domain-containing protein 4 (SETD4) and similar proteins; SETD4 is a ...
 21-239 7.78e-52

SET domain found in SET domain-containing protein 4 (SETD4) and similar proteins; SETD4 is a cytosolic and nuclear functional lysine methyltransferase that plays a crucial role in breast carcinogenesis. However, its specific substrates and modification sites remain to be disclosed.


Pssm-ID: 380954 [Multi-domain]  Cd Length: 245  Bit Score: 172.87  E-value: 7.78e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075849  21 VHPSLEFSVIPDAGSCVLANNDINENTVLLKLPPNILINKRTCSRY-------SFRDKLTSFQFLS-WLISEDVHSnlEI 92
Cdd:cd19177   1 KSSKLKPAEFPDTGRGLVATKDIKPGELIISIPESLLINTTTVLSSllgslikRVKPKLSSLQLLAlFLALEKRRG--EN 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075849  93 SPY--YTKALPQGFSFHPVTLTSDHPLWsiLPDEVRNSLLERKNVMAF----DYEQVKKFVSVDQPT----------FQW 156
Cdd:cd19177  79 SFWapYLDSLPKSFDTHPLYWSLEELSL--LPPSLLEAVRKLLDKQKKrfesDWEIISSVLKSLPSLfdseiftleeFRW 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075849 157 GWLCVNTRCLYYD----TGSKNTEDHLTLAPIFEYFNHSPEAQTALI--NTRGTITIKSTRRIDKGEQIFLCYGPHGNDK 230
Cdd:cd19177 157 AWLCVNTRCVYYKlplsDYLSSSEDNIALAPFLDLLNHSPDVNVKAGfnKSGKCYEIRTGTDYKKGEEVFISYGPHSNDF 236


                ....*....
gi 19075849 231 LFTEYGFCL 239
Cdd:cd19177 237 LLLEYGFVL 245
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 164-230 3.55e-06

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 45.79  E-value: 3.55e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 19075849    164 RCLYYDTGSKNTEDHLTLAPIFEYFNHSPEAQTALINTRGT----ITIKSTRRIDKGEQIFLCYGPHGNDK 230
Cdd:smart00317  54 AFYLFDIDSDLCIDARRKGNLARFINHSCEPNCELLFVEVNgddrIVIFALRDIKPGEELTIDYGSDYANE 124
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 157-224 6.96e-06

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 44.82  E-value: 6.96e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19075849   157 GWLCVNTRCLYYDTGSKntedhltlapifeYFNHSPEAQTAL----INTRGTITIKSTRRIDKGEQIFLCYG 224
Cdd:pfam00856  57 SEYCIDARALYYGNWAR-------------FINHSCDPNCEVrvvyVNGGPRIVIFALRDIKPGEELTIDYG 115
 
Name Accession Description Interval E-value
SET_SETD4 cd19177
SET domain found in SET domain-containing protein 4 (SETD4) and similar proteins; SETD4 is a ...
 21-239 7.78e-52

SET domain found in SET domain-containing protein 4 (SETD4) and similar proteins; SETD4 is a cytosolic and nuclear functional lysine methyltransferase that plays a crucial role in breast carcinogenesis. However, its specific substrates and modification sites remain to be disclosed.


Pssm-ID: 380954 [Multi-domain]  Cd Length: 245  Bit Score: 172.87  E-value: 7.78e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075849  21 VHPSLEFSVIPDAGSCVLANNDINENTVLLKLPPNILINKRTCSRY-------SFRDKLTSFQFLS-WLISEDVHSnlEI 92
Cdd:cd19177   1 KSSKLKPAEFPDTGRGLVATKDIKPGELIISIPESLLINTTTVLSSllgslikRVKPKLSSLQLLAlFLALEKRRG--EN 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075849  93 SPY--YTKALPQGFSFHPVTLTSDHPLWsiLPDEVRNSLLERKNVMAF----DYEQVKKFVSVDQPT----------FQW 156
Cdd:cd19177  79 SFWapYLDSLPKSFDTHPLYWSLEELSL--LPPSLLEAVRKLLDKQKKrfesDWEIISSVLKSLPSLfdseiftleeFRW 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075849 157 GWLCVNTRCLYYD----TGSKNTEDHLTLAPIFEYFNHSPEAQTALI--NTRGTITIKSTRRIDKGEQIFLCYGPHGNDK 230
Cdd:cd19177 157 AWLCVNTRCVYYKlplsDYLSSSEDNIALAPFLDLLNHSPDVNVKAGfnKSGKCYEIRTGTDYKKGEEVFISYGPHSNDF 236


                ....*....
gi 19075849 231 LFTEYGFCL 239
Cdd:cd19177 237 LLLEYGFVL 245
SET_LSMT cd10527
SET domain found in Rubisco large subunit methyltransferase (LSMT) and similar proteins; ...
 24-238 1.26e-30

SET domain found in Rubisco large subunit methyltransferase (LSMT) and similar proteins; Rubisco LSMT is a non-histone protein methyl transferase responsible for the trimethylation of lysine14 in the large subunit of Rubisco (ribulose-1,5-bisphosphate carboxylase/oxygenase). The family also includes SET domain-containing proteins, SETD3, SETD4 and SETD6, which belong to methyltransferase class VII that represents classical non-histone SET domain methyltransferases. Members in this family contain a SET domain and a C-terminal RubisCO LSMT substrate-binding (Rubis-subs-bind) domain.


Pssm-ID: 380925 [Multi-domain]  Cd Length: 236  Bit Score: 116.78  E-value: 1.26e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075849  24 SLEFSVIPDAGSCVLANNDINENTVLLKLPPNILINKRTCSRYSFRDKLTSFQFLSWLISEDVHSNLEI---------SP 94
Cdd:cd10527   1 GVELAESPDGGRGLFATRDIAAGEVLLSVPRSLLLTVETARESPLGGAALALLELDPELSWDVALALFLlyerargpdSF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075849  95 Y--YTKALPQGFSFHPVTLTSDHpLWSILPDEVRNSLLERKNVMAFDYEQVKKFVSVDQP----------TFQWGWLCVN 162
Cdd:cd10527  81 WapYLDSLPRPFEDTPLFWSEEE-LDALQGTPLLEAAAAQRRRLREEYEALVEALPEALPaepgeaftleEFLWALALVL 159

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19075849 163 TRCLYydTGSKNTEDHLTLAPIFEYFNHSPEAQTALIN---TRGTITIKSTRRIDKGEQIFLCYGPHGNDKLFTEYGFC 238
Cdd:cd10527 160 SRAFS--LPVPDGGGGLALVPLADMLNHSPDAPNVRYEydeDEGSFVLVATRDIAAGEEVFISYGPKSNDELLLYYGFV 236
SET_SpSET10-like cd19180
SET domain found in Schizosaccharomyces pombe SET domain-containing protein 10 (SETD10) and ...
 11-238 2.37e-25

SET domain found in Schizosaccharomyces pombe SET domain-containing protein 10 (SETD10) and similar proteins; Schizosaccharomyces pombe SETD10 is a ribosomal S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates ribosomal protein L23 (rpl23a and rpl23b).


Pssm-ID: 380957  Cd Length: 252  Bit Score: 103.19  E-value: 2.37e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075849  11 VSWVKSKGAFVHPSLEFSVIPDAGSCVLAN-NDINENTVLLKLPPNILINKRTCSRYSFRDKLTSFQFLSWLISEDVhsn 89
Cdd:cd19180   1 LEWATENGAKIHPKLEFRYDPDSGISVVATeNAIDPGETLLSIPTSLILTPENARKSFLGALSLASAALESLLPRRL--- 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075849  90 leISPYYT--KALPQGFSFHpvtltsdHPLWSILPDEVRNSLL-------------------ERKNVMAFDYEQVKKFVS 148
Cdd:cd19180  78 --LLVFLLieRRGLGLGSFW-------GPYIDLLPKEFSTPLYwsddelellrgtnlfgavqDRREQLEKEYEVLKEALK 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075849 149 VDQP-----TFQ---WGWLCVNTRC----LYYDTGSKNTEDHLTLAPIFEYFNHSPEAQT--ALINTRGTITIKSTRRID 214
Cdd:cd19180 149 SEHPpkevfTFEdylWAYTIVSSRSfpsrLVSDSGDTSSESEPVLLPLLDLLNHKPGAKVtwNTTDTSSAFELVSGDDLA 228

                       250       260
                ....*....|....*....|....
gi 19075849 215 KGEQIFLCYGPHGNDKLFTEYGFC 238
Cdd:cd19180 229 KGEQVFNNYGPKSNEELLLGYGFV 252
SET_RBCMT cd19179
SET domain found in chloroplastic ribulose-1,5 bisphosphate carboxylase/oxygenase large ...
 37-237 5.73e-11

SET domain found in chloroplastic ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase (RBCMT) and similar proteins; RBCMT (EC 2.1.1.127; also termed [Ribulose-bisphosphate carboxylase]-lysine N-methyltransferase, RuBisCO LSMT, RuBisCO methyltransferase, or rbcMT) methylates 'Lys-14' of the large subunit of RuBisCO.


Pssm-ID: 380956  Cd Length: 237  Bit Score: 61.95  E-value: 5.73e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075849  37 VLANNDINENTVLLKLPPNILINK---RTC-SRYSFRDKLTSFQFLS-WLISEdvHSNLEISPY--YTKALPQgfsfhpv 109
Cdd:cd19179  20 LVAARPIRRGERLLSVPESLWITAetaARSeIGGVLESGLKPWLALAlFLLRE--RSRGEASFWapYIAVLPK------- 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075849 110 TLTSDHPL-WS------ILPDEVRNSLLERKNVMAFDYEQVKKfvSVDQP-------------TFQWGWLCVNTRCLYYD 169
Cdd:cd19179  91 EEELDSPLlWSeeelaeLLGSPLLAATAERKAYVRAEYEALLE--AVFEKnpkvfppevftleAFKWAFGILFSRAFSLL 168

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19075849 170 TGSKntedhLTLAPIFEYFNHSPEAQTAL-INTRG----TITIKSTRRIDKGEQIFLCYGPHGNDKLFTEYGF 237
Cdd:cd19179 169 AGGT-----LALVPWADLLNHSSGVSSDAsYDVRGgsskAVVLTADRNYSAGEQVFISYGPKSNAELLLDYGF 236
SET_SETD6 cd19178
SET domain found in SET domain-containing protein 6 (SETD6) and similar proteins; SETD6 is a ...
 25-237 3.51e-08

SET domain found in SET domain-containing protein 6 (SETD6) and similar proteins; SETD6 is a lysine N-methyltransferase that monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF-kappa-B transcription factor activity. It also monomethylates 'Lys-8' of H2AZ (H2AZK8me1).


Pssm-ID: 380955 [Multi-domain]  Cd Length: 250  Bit Score: 53.85  E-value: 3.51e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075849  25 LEFSV---IPDAGSC----VLANNDINENTVLLKLPPNILINKRTCS-RYSFR-DKLTSFQFLS-W------LISEDVHS 88
Cdd:cd19178   1 IELSPkvaISKLGSSagrgMVATEDIKEGEVLFTVPRSALLSPETSSiADLLEeEEDASLQSLSgWvplllaLMYEYTNP 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075849  89 NLEISPYytkalpqgFSFHPVTLTSDHPL-WSilpDEVRNSLL----------ERKNVMAFDYEQ-VKKFVSVDQPTFQw 156
Cdd:cd19178  81 SSRWRPY--------LSLLPDFSELHHPMfWD---EEEREELLggtgiaeavdRDLKEIDEEYNSiVLPFIKKHPELFS- 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075849 157 gwLCVNTRCLY-----------YDTGSKNTEDHLTLA---------PIFEYFNHSPEAQTALINTRGTITIKSTRRIDKG 216
Cdd:cd19178 149 --PEKHSLELYkrmvafvmaysFTEPDEDEDDDDEDEdddsppmmvPMADMLNHIANNNARLEFDPDCLRMIATRDIKKG 226

                       250       260
                ....*....|....*....|.
gi 19075849 217 EQIFLCYGPHGNDKLFTEYGF 237
Cdd:cd19178 227 EEIFNTYGELANWELLHMYGF 247
SET_SETD3 cd19176
SET domain found in SET domain-containing protein 3 (SETD3) and similar proteins; SETD3 (EC 2. ...
 13-239 4.84e-07

SET domain found in SET domain-containing protein 3 (SETD3) and similar proteins; SETD3 (EC 2.1.1.43) is a histone-lysine N-methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3 (H3K4me and H3K36me). It functions as a transcriptional activator that plays an important role in the transcriptional regulation of muscle cell differentiation via interaction with MYOD1.


Pssm-ID: 380953  Cd Length: 251  Bit Score: 50.33  E-value: 4.84e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075849  13 WVKSKGAFVHPsLEFSVIPDAGSCVLANNDINENTVLLKLPPNILINKRTCSRYSFRDKLTSFQFLS---------WLIS 83
Cdd:cd19176   6 WLKDNGVSLSK-VEIAFFEEEGYGLRATRDIKAGELLLSIPRKLMITAEAAKSSVLGPLIESDPILQampnvalalHLLC 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075849  84 EdvhSNLEISPY--YTKALPQGFSFhPVTLTSDH-------PLWSilpdEVRNSLlerKNVM---AFDYEQVKKFVSVDQ 151
Cdd:cd19176  85 E---RSNPNSFWkpYIDILPSSYTT-PLYFTPEEllllkgsPAFE----EAINQY---RNIArqyAYFYQLLQTSPLASK 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075849 152 P---------TFQWGWLCVNTRCLYYDTGSKNTEDHLTLAPIFEYFNHSPEAQTA--LINTRGTITIkSTRRIDKGEQIF 220
Cdd:cd19176 154 LnlrnsftfdDYRWAVSTVMTRQNQIPTEDGTERSTLALIPLWDMCNHANGKITTdyNLESDSLECV-AMEDFKAGEQVF 232

                       250
                ....*....|....*....
gi 19075849 221 LCYGPHGNDKLFTEYGFCL 239
Cdd:cd19176 233 IFYGPRSNAELLLHSGFVP 251
SET_SMYD4 cd10536
SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing ...
 188-237 1.48e-06

SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing protein 4 (SMYD4) and similar proteins; SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. In zebrafish, SMYD4 is ubiquitously expressed in early embryos and becomes enriched in the developing heart; mutants show a strong defect in cardiomyocyte proliferation, which lead to a severe cardiac malformation.


Pssm-ID: 380934 [Multi-domain]  Cd Length: 218  Bit Score: 48.45  E-value: 1.48e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 19075849 188 FNHSPEAQTALINTRGTITIKSTRRIDKGEQIFLCYGPHGND--------KLFTEYGF 237
Cdd:cd10536 154 LNHSCDPNTIRSFYGNTIVVRATRPIKKGEEITICYGPHFSRmkrserqrLLKEQYFF 211
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 164-230 3.55e-06

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 45.79  E-value: 3.55e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 19075849    164 RCLYYDTGSKNTEDHLTLAPIFEYFNHSPEAQTALINTRGT----ITIKSTRRIDKGEQIFLCYGPHGNDK 230
Cdd:smart00317  54 AFYLFDIDSDLCIDARRKGNLARFINHSCEPNCELLFVEVNgddrIVIFALRDIKPGEELTIDYGSDYANE 124
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 157-224 6.96e-06

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 44.82  E-value: 6.96e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19075849   157 GWLCVNTRCLYYDTGSKntedhltlapifeYFNHSPEAQTAL----INTRGTITIKSTRRIDKGEQIFLCYG 224
Cdd:pfam00856  57 SEYCIDARALYYGNWAR-------------FINHSCDPNCEVrvvyVNGGPRIVIFALRDIKPGEELTIDYG 115
SET_SMYD cd20071
SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing ...
 187-237 1.25e-04

SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing protein, and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1-SYMD5. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions.


Pssm-ID: 380997 [Multi-domain]  Cd Length: 122  Bit Score: 41.21  E-value: 1.25e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 19075849 187 YFNHS--PEAqTALINTRGTITIKSTRRIDKGEQIFLCYGPHGND------KLFTEYGF 237
Cdd:cd20071  58 LLNHScdPNA-VVVFDGNGTLRVRALRDIKAGEELTISYIDPLLPrterrrELLEKYGF 115
SET_SpSet7-like cd10540
SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces ...
 188-226 1.41e-04

SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces pombe Set7 is a novel histone-lysine N-methyltransferase. The family also includes a viral histone H3 lysine 27 methyltransferase from Paramecium bursaria Chlorella virus 1 (PBCV-1).


Pssm-ID: 380938  Cd Length: 112  Bit Score: 40.70  E-value: 1.41e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 19075849 188 FNHS--PEAQTALINTRGTITIKSTRRIDKGEQIFLCYGPH 226
Cdd:cd10540  69 FNHSytPNAEYEIDFENQTIVFYALRDIEAGEELTINYGDD 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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