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Conserved domains on  [gi|19075969|ref|NP_588469|]
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nuclear pore complex component nup97 [Schizosaccharomyces pombe]

Protein Classification

nuclear pore complex Nup93/Nic96 family protein( domain architecture ID 10513692)

nuclear pore complex Nup93/Nic96 family protein; similar to Homo sapiens Nup93 and Saccharomyces cerevisiae Nic96p which are components (nucleoporins, NUPs) of the nuclear pore complex (NPC), which maintain the correct structure of the complex, and which are key factors in its ordered assembly

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Nic96 pfam04097
Nup93/Nic96; Nup93/Nic96 is a component of the nuclear pore complex. It is required for the ...
 213-842 0e+00

Nup93/Nic96; Nup93/Nic96 is a component of the nuclear pore complex. It is required for the correct assembly of the nuclear pore complex. In Saccharomyces cerevisiae, Nic96 has been shown to be involved in the distribution and cellular concentration of the GTPase Gsp1. The structure of Nic96 has revealed a mostly alpha helical structure.


:

Pssm-ID: 461172  Cd Length: 613  Bit Score: 659.66  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075969   213 LYESWKLLSSvILDKDSVTVFGNKGiiskafdietedGSVNSRFYQRISDCSRKFLEAQFFEVLNKEIAKTPQAALVGGV 292
Cdd:pfam04097   3 LVDAWKALAE-ITGEKPAARSDDPP------------GRKSRALRKRIVEGSRRYLEKQFLEYVEELIAKNPREAQLGGV 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075969   293 PSIRNKIRAYLNIRL-LRNGVWINPDLEIIQDVPIWAFIFYLLRCGFLKEAVDFTEENRDLFEKVAEKFPFYINAYAKAP 371
Cdd:pfam04097  70 PGNYNKVRAFVRVRLgLKDGAWDNDNLQIVNGDPLWALIFYLLRCGDLDEALEYVNENGSSFRKIDRSFALYLKAYASSP 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075969   372 NGILPRQLRSQLFSEFNQTIRLQESSDPYKYAVYKIIGRCDLSKTSCPSICSVTEDYIWFQLILSREF-TEKSVSAHEFF 450
Cdd:pfam04097 150 DRRLPPDLEDRLKLEYNQRIRNAPSIDPYKMAVYKIIGRCDLSRRHLESVTLTIEDWLWLQLSLIREDdSRSSEPASERY 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075969   451 SLEDVQHILLSYGSDYFtNNGSNPVMYFFLLMLCGLYERAINFLYPYFP-TDAVHFAITCAYYGLLRTAPSSSvvsnepg 529
Cdd:pfam04097 230 TLSDLQSLILEYGESYF-NASSQPGLYFQVLLLTGQFEAAIEYLYRIDNyVDAVHFAIALAYYGLLRVSDPSS------- 301

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075969   530 kiQSMLveTKSGKPSLEFDRLLIDYTQTCQELSPVMSACYLIPMCKID----KYISMCHKSLCSLVLSTRDYVNLLGDIR 605
Cdd:pfam04097 302 --SSPL--LSQPMRRINFARLIGLYTRDFRASDPREALDYLYLICLNAdlgpEQRNLCHEALRELVLETREFALLLGDIR 377

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075969   606 GDGERTPSFLENHRSLIGLSSVKEYLSKITLTAAKQADDQGLLSDAILLYHLAEDYDAAVTVINRRLGSAL-LRFLDQFV 684
Cdd:pfam04097 378 PDGTRIPGLIEERLPLIKLDDEDDFLRTITEQAAREADEKGRTEDAILLYHLAGEYDKVLSLLNRLLSQVLsQTDRLQPL 457

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075969   685 FP------DKLISLTKSMMDVYNRNPSLYAKVDYKNRETTNLLLLTVEAFNAYTNKDYEQALSSLQQLEILPLDPLDsdc 758
Cdd:pfam04097 458 KPrsdrsvDDPILLAQRILERYESNAEISEKVSAKNRETCRLLLDLLEAFDLYHAGQWDEALDTIEKLDLLPLDPSE--- 534

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075969   759 etfvVRKLAKEFRFLNENLLQNVPGIVLIAMNSLKELYAKQKSSSFGNDAiSVDKLRLYRQKARRIVMYSFLIEYRMPSQ 838
Cdd:pfam04097 535 ----VRAKAQAFKNLPDEVAKNIPDLLLATMTCLSNQYKQLKNSQYSNEG-KRQQLDQLRQKAKALMVFAGMIPYRMPRD 609


                  ....
gi 19075969   839 ILEQ 842
Cdd:pfam04097 610 TYER 613
 
Name Accession Description Interval E-value
Nic96 pfam04097
Nup93/Nic96; Nup93/Nic96 is a component of the nuclear pore complex. It is required for the ...
 213-842 0e+00

Nup93/Nic96; Nup93/Nic96 is a component of the nuclear pore complex. It is required for the correct assembly of the nuclear pore complex. In Saccharomyces cerevisiae, Nic96 has been shown to be involved in the distribution and cellular concentration of the GTPase Gsp1. The structure of Nic96 has revealed a mostly alpha helical structure.


Pssm-ID: 461172  Cd Length: 613  Bit Score: 659.66  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075969   213 LYESWKLLSSvILDKDSVTVFGNKGiiskafdietedGSVNSRFYQRISDCSRKFLEAQFFEVLNKEIAKTPQAALVGGV 292
Cdd:pfam04097   3 LVDAWKALAE-ITGEKPAARSDDPP------------GRKSRALRKRIVEGSRRYLEKQFLEYVEELIAKNPREAQLGGV 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075969   293 PSIRNKIRAYLNIRL-LRNGVWINPDLEIIQDVPIWAFIFYLLRCGFLKEAVDFTEENRDLFEKVAEKFPFYINAYAKAP 371
Cdd:pfam04097  70 PGNYNKVRAFVRVRLgLKDGAWDNDNLQIVNGDPLWALIFYLLRCGDLDEALEYVNENGSSFRKIDRSFALYLKAYASSP 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075969   372 NGILPRQLRSQLFSEFNQTIRLQESSDPYKYAVYKIIGRCDLSKTSCPSICSVTEDYIWFQLILSREF-TEKSVSAHEFF 450
Cdd:pfam04097 150 DRRLPPDLEDRLKLEYNQRIRNAPSIDPYKMAVYKIIGRCDLSRRHLESVTLTIEDWLWLQLSLIREDdSRSSEPASERY 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075969   451 SLEDVQHILLSYGSDYFtNNGSNPVMYFFLLMLCGLYERAINFLYPYFP-TDAVHFAITCAYYGLLRTAPSSSvvsnepg 529
Cdd:pfam04097 230 TLSDLQSLILEYGESYF-NASSQPGLYFQVLLLTGQFEAAIEYLYRIDNyVDAVHFAIALAYYGLLRVSDPSS------- 301

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075969   530 kiQSMLveTKSGKPSLEFDRLLIDYTQTCQELSPVMSACYLIPMCKID----KYISMCHKSLCSLVLSTRDYVNLLGDIR 605
Cdd:pfam04097 302 --SSPL--LSQPMRRINFARLIGLYTRDFRASDPREALDYLYLICLNAdlgpEQRNLCHEALRELVLETREFALLLGDIR 377

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075969   606 GDGERTPSFLENHRSLIGLSSVKEYLSKITLTAAKQADDQGLLSDAILLYHLAEDYDAAVTVINRRLGSAL-LRFLDQFV 684
Cdd:pfam04097 378 PDGTRIPGLIEERLPLIKLDDEDDFLRTITEQAAREADEKGRTEDAILLYHLAGEYDKVLSLLNRLLSQVLsQTDRLQPL 457

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075969   685 FP------DKLISLTKSMMDVYNRNPSLYAKVDYKNRETTNLLLLTVEAFNAYTNKDYEQALSSLQQLEILPLDPLDsdc 758
Cdd:pfam04097 458 KPrsdrsvDDPILLAQRILERYESNAEISEKVSAKNRETCRLLLDLLEAFDLYHAGQWDEALDTIEKLDLLPLDPSE--- 534

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075969   759 etfvVRKLAKEFRFLNENLLQNVPGIVLIAMNSLKELYAKQKSSSFGNDAiSVDKLRLYRQKARRIVMYSFLIEYRMPSQ 838
Cdd:pfam04097 535 ----VRAKAQAFKNLPDEVAKNIPDLLLATMTCLSNQYKQLKNSQYSNEG-KRQQLDQLRQKAKALMVFAGMIPYRMPRD 609


                  ....
gi 19075969   839 ILEQ 842
Cdd:pfam04097 610 TYER 613
 
Name Accession Description Interval E-value
Nic96 pfam04097
Nup93/Nic96; Nup93/Nic96 is a component of the nuclear pore complex. It is required for the ...
 213-842 0e+00

Nup93/Nic96; Nup93/Nic96 is a component of the nuclear pore complex. It is required for the correct assembly of the nuclear pore complex. In Saccharomyces cerevisiae, Nic96 has been shown to be involved in the distribution and cellular concentration of the GTPase Gsp1. The structure of Nic96 has revealed a mostly alpha helical structure.


Pssm-ID: 461172  Cd Length: 613  Bit Score: 659.66  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075969   213 LYESWKLLSSvILDKDSVTVFGNKGiiskafdietedGSVNSRFYQRISDCSRKFLEAQFFEVLNKEIAKTPQAALVGGV 292
Cdd:pfam04097   3 LVDAWKALAE-ITGEKPAARSDDPP------------GRKSRALRKRIVEGSRRYLEKQFLEYVEELIAKNPREAQLGGV 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075969   293 PSIRNKIRAYLNIRL-LRNGVWINPDLEIIQDVPIWAFIFYLLRCGFLKEAVDFTEENRDLFEKVAEKFPFYINAYAKAP 371
Cdd:pfam04097  70 PGNYNKVRAFVRVRLgLKDGAWDNDNLQIVNGDPLWALIFYLLRCGDLDEALEYVNENGSSFRKIDRSFALYLKAYASSP 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075969   372 NGILPRQLRSQLFSEFNQTIRLQESSDPYKYAVYKIIGRCDLSKTSCPSICSVTEDYIWFQLILSREF-TEKSVSAHEFF 450
Cdd:pfam04097 150 DRRLPPDLEDRLKLEYNQRIRNAPSIDPYKMAVYKIIGRCDLSRRHLESVTLTIEDWLWLQLSLIREDdSRSSEPASERY 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075969   451 SLEDVQHILLSYGSDYFtNNGSNPVMYFFLLMLCGLYERAINFLYPYFP-TDAVHFAITCAYYGLLRTAPSSSvvsnepg 529
Cdd:pfam04097 230 TLSDLQSLILEYGESYF-NASSQPGLYFQVLLLTGQFEAAIEYLYRIDNyVDAVHFAIALAYYGLLRVSDPSS------- 301

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075969   530 kiQSMLveTKSGKPSLEFDRLLIDYTQTCQELSPVMSACYLIPMCKID----KYISMCHKSLCSLVLSTRDYVNLLGDIR 605
Cdd:pfam04097 302 --SSPL--LSQPMRRINFARLIGLYTRDFRASDPREALDYLYLICLNAdlgpEQRNLCHEALRELVLETREFALLLGDIR 377

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075969   606 GDGERTPSFLENHRSLIGLSSVKEYLSKITLTAAKQADDQGLLSDAILLYHLAEDYDAAVTVINRRLGSAL-LRFLDQFV 684
Cdd:pfam04097 378 PDGTRIPGLIEERLPLIKLDDEDDFLRTITEQAAREADEKGRTEDAILLYHLAGEYDKVLSLLNRLLSQVLsQTDRLQPL 457

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075969   685 FP------DKLISLTKSMMDVYNRNPSLYAKVDYKNRETTNLLLLTVEAFNAYTNKDYEQALSSLQQLEILPLDPLDsdc 758
Cdd:pfam04097 458 KPrsdrsvDDPILLAQRILERYESNAEISEKVSAKNRETCRLLLDLLEAFDLYHAGQWDEALDTIEKLDLLPLDPSE--- 534

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075969   759 etfvVRKLAKEFRFLNENLLQNVPGIVLIAMNSLKELYAKQKSSSFGNDAiSVDKLRLYRQKARRIVMYSFLIEYRMPSQ 838
Cdd:pfam04097 535 ----VRAKAQAFKNLPDEVAKNIPDLLLATMTCLSNQYKQLKNSQYSNEG-KRQQLDQLRQKAKALMVFAGMIPYRMPRD 609


                  ....
gi 19075969   839 ILEQ 842
Cdd:pfam04097 610 TYER 613
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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