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Conserved domains on  [gi|19076020|ref|NP_588520|]
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transcription factor [Schizosaccharomyces pombe]

Protein Classification

Zn(II)2Cys6 transcription factor( domain architecture ID 10049156)

Zn(II)2Cys6 transcription factor similar to Aspergillus flavus transcription factor UstR, which regulates the expression of the gene cluster that mediates the biosynthesis of ustiloxin B, and to Neurospora crassa transcriptional regulatory protein pro1, which is involved in fruiting body development

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Fungal_trans_2 pfam11951
Fungal specific transcription factor domain; This family of are likely to be transcription ...
 155-522 3.12e-78

Fungal specific transcription factor domain; This family of are likely to be transcription factors. This protein is found in fungi. Proteins in this family are typically between 454 to 826 amino acids in length. This protein is found associated with pfam00172.


:

Pssm-ID: 403235  Cd Length: 384  Bit Score: 250.41  E-value: 3.12e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19076020   155 EYYCYSVAPITTILPGQPNFLPQLLLPMALHEESVLYSLVA-SGYRLKYGNDNSLALQKSKVF-------VNRALLTLPE 226
Cdd:pfam11951   4 DYYLDNVSPLLSPFPESSNPFRKVLLPLALSNPALLHALLAlSAFHLQSSGPPDLWEREAQRYkslalrlLQRALAELSS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19076020   227 RRSLNLSKSEFVVSLacyILLVYTEIAFADTTEWATYFLNAYNMINKMGGFKILK-ECSSEGKLLAECFAYFDILASQSN 305
Cdd:pfam11951  84 RLSSNSKYDDVLAAI---LLLCSFEISSGDVSDWRVHLEGAKDLIRLRGGPSKTSsGLSSLLRFLLRNFAYHDILSSTTT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19076020   306 LNGTYYSISDYTDVYGV---DELQLFESLENCIKPLVLIIGDIINLLVESRRAGFDDLQHTLNIYEKSQTIEGKIwSCVP 382
Cdd:pfam11951 161 GRGPSFPSEEYLDLFGDeleLGSSGLDPLMGCSNSLFLLISEISDLAREKRSLRSDNELLPLEFLSRAQELEQRL-SSWE 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19076020   383 QYEDMKSNKLDSEKSEP---LQLFKLYKTTTEMYLRQVISRMPPVSLEMQVLLHKQTQLIDLLLESSLRN-SLSFPMLIA 458
Cdd:pfam11951 240 PRSDDLEIPLDGEDPLSellLTLTELYRLAALIYLYRRILGLPPSSPEVQELVSKLLELLDLLPDSPLAIsSLLWPLFIA 319

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 19076020   459 GLNAATDLQRTNFKNRVNCLCQNyTIGSLKKVWIVVQEIWKMNQNGNICIDWYEVVQKFGWRLN 522
Cdd:pfam11951 320 GCEAVDDDDRDFVLDRLDSLEKS-RLGNVRRAREILEEVWKRRDDGELSIDWRDVMERLGWDLL 382
GAL4 cd00067
GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like ...
 16-51 9.82e-11

GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like GAL4. Domain consists of two helices organized around a Zn(2)Cys(6 )motif; Binds to sequences containing 2 DNA half sites comprised of 3-5 C/G combinations


:

Pssm-ID: 238023 [Multi-domain]  Cd Length: 36  Bit Score: 56.52  E-value: 9.82e-11
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 19076020  16 RSRYGCLICRSMRKKCDEVHPQCGRCLKAGKQCIWK 51
Cdd:cd00067   1 RVRRACDRCRRRKIKCDGEKPPCSNCIKLGLECTYS 36
 
Name Accession Description Interval E-value
Fungal_trans_2 pfam11951
Fungal specific transcription factor domain; This family of are likely to be transcription ...
 155-522 3.12e-78

Fungal specific transcription factor domain; This family of are likely to be transcription factors. This protein is found in fungi. Proteins in this family are typically between 454 to 826 amino acids in length. This protein is found associated with pfam00172.


Pssm-ID: 403235  Cd Length: 384  Bit Score: 250.41  E-value: 3.12e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19076020   155 EYYCYSVAPITTILPGQPNFLPQLLLPMALHEESVLYSLVA-SGYRLKYGNDNSLALQKSKVF-------VNRALLTLPE 226
Cdd:pfam11951   4 DYYLDNVSPLLSPFPESSNPFRKVLLPLALSNPALLHALLAlSAFHLQSSGPPDLWEREAQRYkslalrlLQRALAELSS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19076020   227 RRSLNLSKSEFVVSLacyILLVYTEIAFADTTEWATYFLNAYNMINKMGGFKILK-ECSSEGKLLAECFAYFDILASQSN 305
Cdd:pfam11951  84 RLSSNSKYDDVLAAI---LLLCSFEISSGDVSDWRVHLEGAKDLIRLRGGPSKTSsGLSSLLRFLLRNFAYHDILSSTTT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19076020   306 LNGTYYSISDYTDVYGV---DELQLFESLENCIKPLVLIIGDIINLLVESRRAGFDDLQHTLNIYEKSQTIEGKIwSCVP 382
Cdd:pfam11951 161 GRGPSFPSEEYLDLFGDeleLGSSGLDPLMGCSNSLFLLISEISDLAREKRSLRSDNELLPLEFLSRAQELEQRL-SSWE 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19076020   383 QYEDMKSNKLDSEKSEP---LQLFKLYKTTTEMYLRQVISRMPPVSLEMQVLLHKQTQLIDLLLESSLRN-SLSFPMLIA 458
Cdd:pfam11951 240 PRSDDLEIPLDGEDPLSellLTLTELYRLAALIYLYRRILGLPPSSPEVQELVSKLLELLDLLPDSPLAIsSLLWPLFIA 319

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 19076020   459 GLNAATDLQRTNFKNRVNCLCQNyTIGSLKKVWIVVQEIWKMNQNGNICIDWYEVVQKFGWRLN 522
Cdd:pfam11951 320 GCEAVDDDDRDFVLDRLDSLEKS-RLGNVRRAREILEEVWKRRDDGELSIDWRDVMERLGWDLL 382
GAL4 cd00067
GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like ...
 16-51 9.82e-11

GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like GAL4. Domain consists of two helices organized around a Zn(2)Cys(6 )motif; Binds to sequences containing 2 DNA half sites comprised of 3-5 C/G combinations


Pssm-ID: 238023 [Multi-domain]  Cd Length: 36  Bit Score: 56.52  E-value: 9.82e-11
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 19076020  16 RSRYGCLICRSMRKKCDEVHPQCGRCLKAGKQCIWK 51
Cdd:cd00067   1 RVRRACDRCRRRKIKCDGEKPPCSNCIKLGLECTYS 36
GAL4 smart00066
GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive ...
 16-57 4.16e-10

GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive regulator for the gene expression of the galactose- induced genes of S. cerevisiae. Is present only in fungi.


Pssm-ID: 214501 [Multi-domain]  Cd Length: 43  Bit Score: 55.06  E-value: 4.16e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 19076020     16 RSRYGCLICRSMRKKCDEVHPQCGRCLKAGKQCIWKQPGTER 57
Cdd:smart00066   2 RVSKACDRCRKRKIKCDGKKPPCSNCIKLGLECTYSDSKKRK 43
Zn_clus pfam00172
Fungal Zn(2)-Cys(6) binuclear cluster domain;
19-53 7.66e-07

Fungal Zn(2)-Cys(6) binuclear cluster domain;


Pssm-ID: 395120 [Multi-domain]  Cd Length: 39  Bit Score: 45.75  E-value: 7.66e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 19076020    19 YGCLICRSMRKKCDEVHPQCGRCLKAGKQCIWKQP 53
Cdd:pfam00172   1 TACDNCRKRKVKCDGKKPACSRCIKNGLECTYSRK 35
 
Name Accession Description Interval E-value
Fungal_trans_2 pfam11951
Fungal specific transcription factor domain; This family of are likely to be transcription ...
 155-522 3.12e-78

Fungal specific transcription factor domain; This family of are likely to be transcription factors. This protein is found in fungi. Proteins in this family are typically between 454 to 826 amino acids in length. This protein is found associated with pfam00172.


Pssm-ID: 403235  Cd Length: 384  Bit Score: 250.41  E-value: 3.12e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19076020   155 EYYCYSVAPITTILPGQPNFLPQLLLPMALHEESVLYSLVA-SGYRLKYGNDNSLALQKSKVF-------VNRALLTLPE 226
Cdd:pfam11951   4 DYYLDNVSPLLSPFPESSNPFRKVLLPLALSNPALLHALLAlSAFHLQSSGPPDLWEREAQRYkslalrlLQRALAELSS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19076020   227 RRSLNLSKSEFVVSLacyILLVYTEIAFADTTEWATYFLNAYNMINKMGGFKILK-ECSSEGKLLAECFAYFDILASQSN 305
Cdd:pfam11951  84 RLSSNSKYDDVLAAI---LLLCSFEISSGDVSDWRVHLEGAKDLIRLRGGPSKTSsGLSSLLRFLLRNFAYHDILSSTTT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19076020   306 LNGTYYSISDYTDVYGV---DELQLFESLENCIKPLVLIIGDIINLLVESRRAGFDDLQHTLNIYEKSQTIEGKIwSCVP 382
Cdd:pfam11951 161 GRGPSFPSEEYLDLFGDeleLGSSGLDPLMGCSNSLFLLISEISDLAREKRSLRSDNELLPLEFLSRAQELEQRL-SSWE 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19076020   383 QYEDMKSNKLDSEKSEP---LQLFKLYKTTTEMYLRQVISRMPPVSLEMQVLLHKQTQLIDLLLESSLRN-SLSFPMLIA 458
Cdd:pfam11951 240 PRSDDLEIPLDGEDPLSellLTLTELYRLAALIYLYRRILGLPPSSPEVQELVSKLLELLDLLPDSPLAIsSLLWPLFIA 319

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 19076020   459 GLNAATDLQRTNFKNRVNCLCQNyTIGSLKKVWIVVQEIWKMNQNGNICIDWYEVVQKFGWRLN 522
Cdd:pfam11951 320 GCEAVDDDDRDFVLDRLDSLEKS-RLGNVRRAREILEEVWKRRDDGELSIDWRDVMERLGWDLL 382
GAL4 cd00067
GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like ...
 16-51 9.82e-11

GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like GAL4. Domain consists of two helices organized around a Zn(2)Cys(6 )motif; Binds to sequences containing 2 DNA half sites comprised of 3-5 C/G combinations


Pssm-ID: 238023 [Multi-domain]  Cd Length: 36  Bit Score: 56.52  E-value: 9.82e-11
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 19076020  16 RSRYGCLICRSMRKKCDEVHPQCGRCLKAGKQCIWK 51
Cdd:cd00067   1 RVRRACDRCRRRKIKCDGEKPPCSNCIKLGLECTYS 36
GAL4 smart00066
GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive ...
 16-57 4.16e-10

GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive regulator for the gene expression of the galactose- induced genes of S. cerevisiae. Is present only in fungi.


Pssm-ID: 214501 [Multi-domain]  Cd Length: 43  Bit Score: 55.06  E-value: 4.16e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 19076020     16 RSRYGCLICRSMRKKCDEVHPQCGRCLKAGKQCIWKQPGTER 57
Cdd:smart00066   2 RVSKACDRCRKRKIKCDGKKPPCSNCIKLGLECTYSDSKKRK 43
Zn_clus pfam00172
Fungal Zn(2)-Cys(6) binuclear cluster domain;
19-53 7.66e-07

Fungal Zn(2)-Cys(6) binuclear cluster domain;


Pssm-ID: 395120 [Multi-domain]  Cd Length: 39  Bit Score: 45.75  E-value: 7.66e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 19076020    19 YGCLICRSMRKKCDEVHPQCGRCLKAGKQCIWKQP 53
Cdd:pfam00172   1 TACDNCRKRKVKCDGKKPACSRCIKNGLECTYSRK 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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