|
Name |
Accession |
Description |
Interval |
E-value |
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
275-904 |
1.91e-129 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 405.38 E-value: 1.91e-129
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 275 DLESALVVKQPRPVIPKGRRGRREKTPLGPRLVGICMEIMRGYFVVDALIRQCEQLGGKIQRGIEAWGLSNTATSDEGET 354
Cdd:COG0553 132 LLLLALLLVLLAALLLLLLLLLLLALLLGRLLLLALLLLALEALLLLGLLLALALLALLELALLAAEAELLLLLELLLEL 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 355 SLVNFDQMKSFGTPANSSFITTPPASFspDIKLQDYQIIGINWLYLLYELKLAGILADEMGLGKTCQTIAFFSLLMDKNI 434
Cdd:COG0553 212 ELLAEAAVDAFRLRRLREALESLPAGL--KATLRPYQLEGAAWLLFLRRLGLGGLLADDMGLGKTIQALALLLELKERGL 289
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 435 NGPHLVIAPASTMENWLREFAKFCPKLKIELYYGSQvEREEIRERInsnkDSYNVMLTTYrlaATSKADRLFLRNQKFNV 514
Cdd:COG0553 290 ARPVLIVAPTSLVGNWQRELAKFAPGLRVLVLDGTR-ERAKGANPF----EDADLVITSY---GLLRRDIELLAAVDWDL 361
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 515 CVYDEGHYLKNRASERYRHLMSIPADFRVLLTGTPLQNNLKELISLLAFILPHVFdYGLKSldviFTmkkspeSDFERAL 594
Cdd:COG0553 362 VILDEAQHIKNPATKRAKAVRALKARHRLALTGTPVENRLEELWSLLDFLNPGLL-GSLKA----FR------ERFARPI 430
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 595 L--SEQRVSRAKMMMAPFVLRRKKSQVLDALPKKTRIIEFCEFSEEERRRYDdfaskqSVNSLLDENVmktnldTNANLA 672
Cdd:COG0553 431 EkgDEEALERLRRLLRPFLLRRTKEDVLKDLPEKTEETLYVELTPEQRALYE------AVLEYLRREL------EGAEGI 498
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 673 KKKSTAGFVLVQLRKLADHPMLFrihykddilrqmakaimnepqykkanelyifedmqymsdielhnlcckfpsinsfqL 752
Cdd:COG0553 499 RRRGLILAALTRLRQICSHPALL--------------------------------------------------------L 522
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 753 KDEPWMDAT--KVRKLKKLLTNAVENGDRVVLFSQFTQVLDILQLVMKSLNLKFLRFDGSTQVDFRQDLIDQFYADESIN 830
Cdd:COG0553 523 EEGAELSGRsaKLEALLELLEELLAEGEKVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQEGPEAP 602
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 19114529 831 VFLLSTKAGGFGINLACANMVILYDVSFNPFDDLQAEDRAHRVGQKKEVTVYKFVVKDTIEEHIQRLANAKIAL 904
Cdd:COG0553 603 VFLISLKAGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILELLEEKRAL 676
|
|
| DEXHc_SMARCAD1 |
cd17998 |
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent ... |
387-569 |
1.52e-106 |
|
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1, also known as ATP-dependent helicase 1 or Hel1) possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization. SMARCAD1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350756 [Multi-domain] Cd Length: 187 Bit Score: 327.42 E-value: 1.52e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 387 LQDYQIIGINWLYLLYELKLAGILADEMGLGKTCQTIAFFSLLMDKNINGPHLVIAPASTMENWLREFAKFCPKLKIELY 466
Cdd:cd17998 1 LKDYQLIGLNWLNLLYQKKLSGILADEMGLGKTIQVIAFLAYLKEIGIPGPHLVVVPSSTLDNWLREFKRWCPSLKVEPY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 467 YGSQVEREEIRERINSNKDSYNVMLTTYRLAATSKADRLFLRNQKFNVCVYDEGHYLKNRASERYRHLMSIPADFRVLLT 546
Cdd:cd17998 81 YGSQEERKHLRYDILKGLEDFDVIVTTYNLATSNPDDRSFFKRLKLNYVVYDEGHMLKNMTSERYRHLMTINANFRLLLT 160
|
170 180
....*....|....*....|...
gi 19114529 547 GTPLQNNLKELISLLAFILPHVF 569
Cdd:cd17998 161 GTPLQNNLLELMSLLNFIMPKPF 183
|
|
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
386-906 |
8.37e-92 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 313.66 E-value: 8.37e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 386 KLQDYQIIGINWLYLLYELKLAGILADEMGLGKTCQTIAFFSLLMD-KNINGPHLVIAPASTMENWLREFAKFCPKLKIE 464
Cdd:PLN03142 169 KMRDYQLAGLNWLIRLYENGINGILADEMGLGKTLQTISLLGYLHEyRGITGPHMVVAPKSTLGNWMNEIRRFCPVLRAV 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 465 LYYGSQVEREEIRERInSNKDSYNVMLTTYRLAATSKADrlfLRNQKFNVCVYDEGHYLKNRASERYRHLMSIPADFRVL 544
Cdd:PLN03142 249 KFHGNPEERAHQREEL-LVAGKFDVCVTSFEMAIKEKTA---LKRFSWRYIIIDEAHRIKNENSLLSKTMRLFSTNYRLL 324
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 545 LTGTPLQNNLKELISLLAFILPHVFDYGlKSLDVIFTMkkSPESDferallSEQRVSRAKMMMAPFVLRRKKSQVLDALP 624
Cdd:PLN03142 325 ITGTPLQNNLHELWALLNFLLPEIFSSA-ETFDEWFQI--SGEND------QQEVVQQLHKVLRPFLLRRLKSDVEKGLP 395
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 625 KKTRIIEFCEFSEEERRRYDDFASKqsvnsllDENVMKTNLDTNANLAkkkstagfVLVQLRKLADHPMLFrihykddil 704
Cdd:PLN03142 396 PKKETILKVGMSQMQKQYYKALLQK-------DLDVVNAGGERKRLLN--------IAMQLRKCCNHPYLF--------- 451
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 705 rQMAKAimnEPQYKKANELyifedmqymsdIElhnlcckfpsinsfqlkdepwmDATKVRKLKKLLTNAVENGDRVVLFS 784
Cdd:PLN03142 452 -QGAEP---GPPYTTGEHL-----------VE----------------------NSGKMVLLDKLLPKLKERDSRVLIFS 494
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 785 QFTQVLDILQLVMKSLNLKFLRFDGSTQVDFRQDLIDQFYADESIN-VFLLSTKAGGFGINLACANMVILYDVSFNPFDD 863
Cdd:PLN03142 495 QMTRLLDILEDYLMYRGYQYCRIDGNTGGEDRDASIDAFNKPGSEKfVFLLSTRAGGLGINLATADIVILYDSDWNPQVD 574
|
490 500 510 520
....*....|....*....|....*....|....*....|...
gi 19114529 864 LQAEDRAHRVGQKKEVTVYKFVVKDTIEEHIQRLANAKIALDA 906
Cdd:PLN03142 575 LQAQDRAHRIGQKKEVQVFRFCTEYTIEEKVIERAYKKLALDA 617
|
|
| DEXHc_Snf |
cd17919 |
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ... |
387-569 |
5.06e-71 |
|
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350677 [Multi-domain] Cd Length: 182 Bit Score: 232.46 E-value: 5.06e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 387 LQDYQIIGINWLYLLYELKLAGILADEMGLGKTCQTIAFFSLLM-DKNINGPHLVIAPASTMENWLREFAKFCPKLKIEL 465
Cdd:cd17919 1 LRPYQLEGLNFLLELYENGPGGILADEMGLGKTLQAIAFLAYLLkEGKERGPVLVVCPLSVLENWEREFEKWTPDLRVVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 466 YYGSQveREEIRERINSNKDSYNVMLTTYRLAatsKADRLFLRNQKFNVCVYDEGHYLKNRASERYRHLMSIPADFRVLL 545
Cdd:cd17919 81 YHGSQ--RERAQIRAKEKLDKFDVVLTTYETL---RRDKASLRKFRWDLVVVDEAHRLKNPKSQLSKALKALRAKRRLLL 155
|
170 180
....*....|....*....|....
gi 19114529 546 TGTPLQNNLKELISLLAFILPHVF 569
Cdd:cd17919 156 TGTPLQNNLEELWALLDFLDPPFL 179
|
|
| DEXHc_HELLS_SMARCA6 |
cd18009 |
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or ... |
386-616 |
5.02e-67 |
|
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or SMARCA6) is a major epigenetic regulator crucial for normal heterochromatin structure and function. HELLS is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350767 [Multi-domain] Cd Length: 236 Bit Score: 223.80 E-value: 5.02e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 386 KLQDYQIIGINWLYLLYELKLAGILADEMGLGKTCQTIAFFSLLMDKNINGPHLVIAPASTMENWLREFAKFCPKLKIEL 465
Cdd:cd18009 3 VMRPYQLEGMEWLRMLWENGINGILADEMGLGKTIQTIALLAHLRERGVWGPFLVIAPLSTLPNWVNEFARFTPSVPVLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 466 YYGSQVEREEIRERINSNKDS---YNVMLTTYRLAATskaDRLFLRNQKFNVCVYDEGHYLKNRASERYRHLMSIPADFR 542
Cdd:cd18009 83 YHGTKEERERLRKKIMKREGTlqdFPVVVTSYEIAMR---DRKALQHYAWKYLIVDEGHRLKNLNCRLIQELKTFNSDNR 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19114529 543 VLLTGTPLQNNLKELISLLAFILPHVFDyGLKSLDVIFTMKKSPESDFERALLSEQR----VSRAKMMMAPFVLRRKK 616
Cdd:cd18009 160 LLLTGTPLQNNLSELWSLLNFLLPDVFD-DLSSFESWFDFSSLSDNAADISNLSEEReqniVHMLHAILKPFLLRRLK 236
|
|
| DEXQc_SRCAP |
cd18003 |
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ... |
387-614 |
2.09e-64 |
|
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350761 [Multi-domain] Cd Length: 223 Bit Score: 216.06 E-value: 2.09e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 387 LQDYQIIGINWLYLLYELKLAGILADEMGLGKTCQTIAFFS-LLMDKNINGPHLVIAPASTMENWLREFAKFCPKLKIEL 465
Cdd:cd18003 1 LREYQHIGLDWLATLYEKNLNGILADEMGLGKTIQTIALLAhLACEKGNWGPHLIVVPTSVMLNWEMEFKRWCPGFKILT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 466 YYGSQVEREEIRERInSNKDSYNVMLTTYRLAATskaDRLFLRNQKFNVCVYDEGHYLKNRASERYRHLMSIPADFRVLL 545
Cdd:cd18003 81 YYGSAKERKLKRQGW-MKPNSFHVCITSYQLVVQ---DHQVFKRKKWKYLILDEAHNIKNFKSQRWQTLLNFNTQRRLLL 156
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 19114529 546 TGTPLQNNLKELISLLAFILPHVFDyglkSLDVIFTMKKSPESDF--ERALLSEQRVSRAKMMMAPFVLRR 614
Cdd:cd18003 157 TGTPLQNSLMELWSLMHFLMPHIFQ----SHQEFKEWFSNPLTAMseGSQEENEELVRRLHKVLRPFLLRR 223
|
|
| SNF2-rel_dom |
pfam00176 |
SNF2-related domain; This domain is found in proteins involved in a variety of processes ... |
390-695 |
6.80e-61 |
|
SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.
Pssm-ID: 425504 [Multi-domain] Cd Length: 289 Bit Score: 208.69 E-value: 6.80e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 390 YQIIGINWLYLLYE-LKLAGILADEMGLGKTCQTIAF--FSLLMDKNINGPHLVIAPASTMENWLREFAKFC--PKLKIE 464
Cdd:pfam00176 1 YQIEGVNWMLSLENnLGRGGILADEMGLGKTLQTISLllYLKHVDKNWGGPTLIVVPLSLLHNWMNEFERWVspPALRVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 465 LYYGSQVEREEIRERINSNKDsYNVMLTTYrlaatskaDRLFLRNQKFNVC-----VYDEGHYLKNRASERYRHLMSIPA 539
Cdd:pfam00176 81 VLHGNKRPQERWKNDPNFLAD-FDVVITTY--------ETLRKHKELLKKVhwhriVLDEGHRLKNSKSKLSKALKSLKT 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 540 DFRVLLTGTPLQNNLKELISLLAFILPHVFdyglkslDVIFTMKKSPESDFERAlLSEQRVSRAKMMMAPFVLRRKKSQV 619
Cdd:pfam00176 152 RNRWILTGTPLQNNLEELWALLNFLRPGPF-------GSLSTFRNWFDRPIERG-GGKKGVSRLHKLLKPFLLRRTKKDV 223
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19114529 620 LDALPKKTRIIEFCEFSEEERRRYDDFASKQSVNSLLDENVMKTNLDTNANLakkkstagfvLVQLRKLADHPMLF 695
Cdd:pfam00176 224 EKSLPPKVEYILFCRLSKLQRKLYQTFLLKKDLNAIKTGEGGREIKASLLNI----------LMRLRKICNHPGLI 289
|
|
| DEXQc_arch_SWI2_SNF2 |
cd18012 |
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ... |
387-616 |
1.48e-60 |
|
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350770 [Multi-domain] Cd Length: 218 Bit Score: 205.11 E-value: 1.48e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 387 LQDYQIIGINWLYLLYELKLAGILADEMGLGKTCQTIAFFSLLMDKNINGPHLVIAPASTMENWLREFAKFCPKLKIELY 466
Cdd:cd18012 5 LRPYQKEGFNWLSFLRHYGLGGILADDMGLGKTLQTLALLLSRKEEGRKGPSLVVAPTSLIYNWEEEAAKFAPELKVLVI 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 467 YGSQVEREEIRERinsnkDSYNVMLTTYrlaATSKADRLFLRNQKFNVCVYDEGHYLKNRASERYRHLMSIPADFRVLLT 546
Cdd:cd18012 85 HGTKRKREKLRAL-----EDYDLVITSY---GLLRRDIELLKEVKFHYLVLDEAQNIKNPQTKTAKAVKALKADHRLALT 156
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19114529 547 GTPLQNNLKELISLLAFILPHVfdygLKSLDViFTmkkspeSDFERALLSEQRVSRA---KMMMAPFVLRRKK 616
Cdd:cd18012 157 GTPIENHLGELWSIFDFLNPGL----LGSYKR-FK------KRFAKPIEKDGDEEALeelKKLISPFILRRLK 218
|
|
| DEXHc_SMARCA2_SMARCA4 |
cd17996 |
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin ... |
386-616 |
1.62e-59 |
|
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, members 2 and 4 (SMARCA2 and SMARCA4) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350754 [Multi-domain] Cd Length: 233 Bit Score: 202.98 E-value: 1.62e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 386 KLQDYQIIGINWLYLLYELKLAGILADEMGLGKTCQTIAFFSLLMD-KNINGPHLVIAPASTMENWLREFAKFCPKLKIE 464
Cdd:cd17996 3 TLKEYQLKGLQWMVSLYNNNLNGILADEMGLGKTIQTISLITYLMEkKKNNGPYLVIVPLSTLSNWVSEFEKWAPSVSKI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 465 LYYGSQVEREEIRERINSNKdsYNVMLTTYRLAATskaDRLFLRNQKFNVCVYDEGHYLKNRASE------RYRHlmsip 538
Cdd:cd17996 83 VYKGTPDVRKKLQSQIRAGK--FNVLLTTYEYIIK---DKPLLSKIKWKYMIIDEGHRMKNAQSKltqtlnTYYH----- 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 539 ADFRVLLTGTPLQNNLKELISLLAFILPHVFDyGLKSLDVIFTMKKSPESDFERALLSEQR----VSRAKMMMAPFVLRR 614
Cdd:cd17996 153 ARYRLLLTGTPLQNNLPELWALLNFLLPKIFK-SCKTFEQWFNTPFANTGEQVKIELNEEEtlliIRRLHKVLRPFLLRR 231
|
..
gi 19114529 615 KK 616
Cdd:cd17996 232 LK 233
|
|
| DEXQc_INO80 |
cd18002 |
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 ... |
387-614 |
5.34e-57 |
|
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INO80 removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. INO80 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350760 [Multi-domain] Cd Length: 229 Bit Score: 195.80 E-value: 5.34e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 387 LQDYQIIGINWLYLLYELKLAGILADEMGLGKTCQTIAFFSLLMD-KNINGPHLVIAPASTMENWLREFAKFCPKLKIEL 465
Cdd:cd18002 1 LKEYQLKGLNWLANLYEQGINGILADEMGLGKTVQSIAVLAHLAEeHNIWGPFLVIAPASTLHNWQQEISRFVPQFKVLP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 466 YYGSQVEREEIRERINSN----KDS-YNVMLTTYRLAATskaDRLFLRNQKFNVCVYDEGHYLKNRASERYRHLMSIPAD 540
Cdd:cd18002 81 YWGNPKDRKVLRKFWDRKnlytRDApFHVVITSYQLVVQ---DEKYFQRVKWQYMVLDEAQAIKSSSSSRWKTLLSFHCR 157
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19114529 541 FRVLLTGTPLQNNLKELISLLAFILPHVFDyGLKSLDVIFTmkKSPESDFE-RALLSEQRVSRAKMMMAPFVLRR 614
Cdd:cd18002 158 NRLLLTGTPIQNSMAELWALLHFIMPTLFD-SHDEFNEWFS--KDIESHAEnKTGLNEHQLKRLHMILKPFMLRR 229
|
|
| DEXHc_SMARCA1_SMARCA5 |
cd17997 |
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin ... |
386-616 |
1.24e-56 |
|
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 and 5 (SMARCA1 and SMARCA5) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350755 [Multi-domain] Cd Length: 222 Bit Score: 194.46 E-value: 1.24e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 386 KLQDYQIIGINWLYLLYELKLAGILADEMGLGKTCQTIAFFSLLMD-KNINGPHLVIAPASTMENWLREFAKFCPKLKIE 464
Cdd:cd17997 3 TMRDYQIRGLNWLISLFENGINGILADEMGLGKTLQTISLLGYLKHyKNINGPHLIIVPKSTLDNWMREFKRWCPSLRVV 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 465 LYYGSQVEREEIRERINSNKDsYNVMLTTYRLAATSKAdrlFLRNQKFNVCVYDEGHYLKNRASERYRHLMSIPADFRVL 544
Cdd:cd17997 83 VLIGDKEERADIIRDVLLPGK-FDVCITSYEMVIKEKT---VLKKFNWRYIIIDEAHRIKNEKSKLSQIVRLFNSRNRLL 158
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19114529 545 LTGTPLQNNLKELISLLAFILPHVFDyglksldviftmkkSPEsDF-------ERALLSEQRVSRAKMMMAPFVLRRKK 616
Cdd:cd17997 159 LTGTPLQNNLHELWALLNFLLPDVFT--------------SSE-DFdewfnvnNCDDDNQEVVQRLHKVLRPFLLRRIK 222
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
761-885 |
2.91e-54 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 184.60 E-value: 2.91e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 761 TKVRKLKKLLTNAVENGDRVVLFSQFTQVLDILQLVMKSLNLKFLRFDGSTQVDFRQDLIDQFYADESINVFLLSTKAGG 840
Cdd:cd18793 11 GKLEALLELLEELREPGEKVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDIRVFLLSTKAGG 90
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 19114529 841 FGINLACANMVILYDVSFNPFDDLQAEDRAHRVGQKKEVTVYKFV 885
Cdd:cd18793 91 VGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
|
|
| DEXHc_CHD1_2 |
cd17993 |
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and ... |
386-614 |
8.89e-54 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and similar proteins; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as the substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but is also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. Both are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350751 [Multi-domain] Cd Length: 218 Bit Score: 186.41 E-value: 8.89e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 386 KLQDYQIIGINWLYLLYELKLAGILADEMGLGKTCQTIAFFSLLM-DKNINGPHLVIAPASTMENWLREFAKFCPKLKIE 464
Cdd:cd17993 1 ELRDYQLTGLNWLAHSWCKGNNGILADEMGLGKTVQTISFLSYLFhSQQQYGPFLVVVPLSTMPAWQREFAKWAPDMNVI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 465 LYYGSQVEREEIRE----RINSNKDSYNVMLTTYRLAATskaDRLFLRNQKFNVCVYDEGHYLKNRASERYRHLMSIPAD 540
Cdd:cd17993 81 VYLGDIKSRDTIREyefyFSQTKKLKFNVLLTTYEIILK---DKAFLGSIKWQYLAVDEAHRLKNDESLLYEALKEFKTN 157
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 19114529 541 FRVLLTGTPLQNNLKELISLLAFILPHVFDYglksldviftmkkSPESDFERALLSEQRVSRAKMMMAPFVLRR 614
Cdd:cd17993 158 NRLLITGTPLQNSLKELWALLHFLMPGKFDI-------------WEEFEEEHDEEQEKGIADLHKELEPFILRR 218
|
|
| DEXHc_CHD1L |
cd18006 |
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, ... |
387-614 |
4.66e-51 |
|
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350764 [Multi-domain] Cd Length: 216 Bit Score: 178.79 E-value: 4.66e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 387 LQDYQIIGINWLYLLYELKLAGILADEMGLGKTCQTIAFFSLLMDK-NINGPHLVIAPASTMENWLREFAKFCPKLKIEL 465
Cdd:cd18006 1 LRPYQLEGVNWLLQCRAEQHGCILGDEMGLGKTCQTISLLWYLAGRlKLLGPFLVLCPLSVLDNWKEELNRFAPDLSVIT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 466 YYGSQVEREEIRERINSNKDsYNVMLTTYRLAATskaDRLFLRNQKFNVCVYDEGHYLKNRASERYRHLMSIPADFRVLL 545
Cdd:cd18006 81 YMGDKEKRLDLQQDIKSTNR-FHVLLTTYEICLK---DASFLKSFPWASLVVDEAHRLKNQNSLLHKTLSEFSVDFRLLL 156
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19114529 546 TGTPLQNNLKELISLLAFILPHVFdyGLKSLDVIftMKKSPESDFERALLSEqrvsrAKMMMAPFVLRR 614
Cdd:cd18006 157 TGTPIQNSLQELYALLSFIEPNVF--PKDKLDDF--IKAYSETDDESETVEE-----LHLLLQPFLLRR 216
|
|
| DEXHc_CHD6_7_8_9 |
cd17995 |
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; ... |
387-614 |
2.02e-50 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; Chromodomain-helicase-DNA-binding protein 6-9 (CHD6, CHD7, CHD8, and CHD9) are members of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350753 [Multi-domain] Cd Length: 223 Bit Score: 177.06 E-value: 2.02e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 387 LQDYQIIGINWLYLLYELKLAGILADEMGLGKTCQTIAFFS-LLMDKNINGPHLVIAPASTMENWLREFAKFCPkLKIEL 465
Cdd:cd17995 1 LRDYQLEGVNWLLFNWYNRRNCILADEMGLGKTIQSIAFLEhLYQVEGIRGPFLVIAPLSTIPNWQREFETWTD-MNVVV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 466 YYGSQVEREEIRERINSNKDSY----------NVMLTTYRLAAtskADRLFLRNQKFNVCVYDEGHYLKNRASERYRHLM 535
Cdd:cd17995 80 YHGSGESRQIIQQYEMYFKDAQgrkkkgvykfDVLITTYEMVI---ADAEELRKIPWRVVVVDEAHRLKNRNSKLLQGLK 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 536 SIPADFRVLLTGTPLQNNLKELISLLAFILPHVFdyglksldviftmkkSPESDFERA---LLSEQRVSRAKMMMAPFVL 612
Cdd:cd17995 157 KLTLEHKLLLTGTPLQNNTEELWSLLNFLEPEKF---------------PSSEEFLEEfgdLKTAEQVEKLQALLKPYML 221
|
..
gi 19114529 613 RR 614
Cdd:cd17995 222 RR 223
|
|
| DEXHc_ERCC6L |
cd18001 |
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ... |
387-614 |
1.96e-44 |
|
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350759 [Multi-domain] Cd Length: 232 Bit Score: 160.23 E-value: 1.96e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 387 LQDYQIIGINWLYLLYELKLAGILADEMGLGKTCQTIAFFSLLMDKNINGPHLVIAPASTMENWLREFAKFCPKLKIELY 466
Cdd:cd18001 1 LYPHQREGVAWLWSLHDGGKGGILADDMGLGKTVQICAFLSGMFDSGLIKSVLVVMPTSLIPHWVKEFAKWTPGLRVKVF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 467 YGSQV-EREEIRERINSNKdsyNVMLTTYRLaATSKADRL---FLRNQKFNVCVYDEGHYLKNRASERYRHLMSIPADFR 542
Cdd:cd18001 81 HGTSKkERERNLERIQRGG---GVLLTTYGM-VLSNTEQLsadDHDEFKWDYVILDEGHKIKNSKTKSAKSLREIPAKNR 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 543 VLLTGTPLQNNLKELISLLAFILPHVFDYGLKSLDVIF-------TMKKSpeSDFERALLSEqrVSRAKM-MMAPFVLRR 614
Cdd:cd18001 157 IILTGTPIQNNLKELWALFDFACNGSLLGTRKTFKMEFenpitrgRDKDA--TQGEKALGSE--VAENLRqIIKPYFLRR 232
|
|
| DEXHc_ERCC6 |
cd18000 |
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, ... |
387-566 |
1.29e-43 |
|
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350758 [Multi-domain] Cd Length: 193 Bit Score: 156.72 E-value: 1.29e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 387 LQDYQIIGINWLYLLYELKLAGILADEMGLGKTCQTIAFF-SLLMDKNINGPHLVIAPASTMENWLREFAKFCPKLKIEL 465
Cdd:cd18000 1 LFKYQQTGVQWLWELHCQRVGGILGDEMGLGKTIQIIAFLaALHHSKLGLGPSLIVCPATVLKQWVKEFHRWWPPFRVVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 466 YYGS---------QVEREEIRERINSNKDSYNVMLTTYRLAATSKAdrlFLRNQKFNVCVYDEGHYLKNRASERYRHLMS 536
Cdd:cd18000 81 LHSSgsgtgseekLGSIERKSQLIRKVVGDGGILITTYEGFRKHKD---LLLNHNWQYVILDEGHKIRNPDAEITLACKQ 157
|
170 180 190
....*....|....*....|....*....|
gi 19114529 537 IPADFRVLLTGTPLQNNLKELISLLAFILP 566
Cdd:cd18000 158 LRTPHRLILSGTPIQNNLKELWSLFDFVFP 187
|
|
| DEXHc_SMARCA5 |
cd18064 |
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent ... |
386-626 |
5.55e-43 |
|
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (SMARCA5, also called SNF2H) is the catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. SMARCA5 plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding SMARCA5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350822 [Multi-domain] Cd Length: 244 Bit Score: 156.75 E-value: 5.55e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 386 KLQDYQIIGINWLYLLYELKLAGILADEMGLGKTCQTIAFFSLLMD-KNINGPHLVIAPASTMENWLREFAKFCPKLKIE 464
Cdd:cd18064 15 KLRDYQVRGLNWLISLYENGINGILADEMGLGKTLQTISLLGYMKHyRNIPGPHMVLVPKSTLHNWMAEFKRWVPTLRAV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 465 LYYGSQVEREE-IRERINSNKdsYNVMLTTYRLAATSKAdrLFlrnQKFN--VCVYDEGHYLKNRASERYRHLMSIPADF 541
Cdd:cd18064 95 CLIGDKDQRAAfVRDVLLPGE--WDVCVTSYEMLIKEKS--VF---KKFNwrYLVIDEAHRIKNEKSKLSEIVREFKTTN 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 542 RVLLTGTPLQNNLKELISLLAFILPHVFDYGlKSLDVIFtmkkspesDFERALLSEQRVSRAKMMMAPFVLRRKKSQVLD 621
Cdd:cd18064 168 RLLLTGTPLQNNLHELWALLNFLLPDVFNSA-EDFDSWF--------DTNNCLGDQKLVERLHMVLRPFLLRRIKADVEK 238
|
....*
gi 19114529 622 ALPKK 626
Cdd:cd18064 239 SLPPK 243
|
|
| DEXHc_CHD2 |
cd18054 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; ... |
385-571 |
2.32e-42 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. CHD2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350812 [Multi-domain] Cd Length: 237 Bit Score: 154.78 E-value: 2.32e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 385 IKLQDYQIIGINWLYLLYELKLAGILADEMGLGKTCQTIAFFSLLMDKN-INGPHLVIAPASTMENWLREFAKFCPKLKI 463
Cdd:cd18054 19 LELRDYQLEGLNWLAHSWCKNNSVILADEMGLGKTIQTISFLSYLFHQHqLYGPFLLVVPLSTLTSWQREFEIWAPEINV 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 464 ELYYGSQVEREEIRE----RINSNKDSYNVMLTTYRLAATSKAdrlFLRNQKFNVCVYDEGHYLKNRASERYRHLMSIPA 539
Cdd:cd18054 99 VVYIGDLMSRNTIREyewiHSQTKRLKFNALITTYEILLKDKT---VLGSINWAFLGVDEAHRLKNDDSLLYKTLIDFKS 175
|
170 180 190
....*....|....*....|....*....|..
gi 19114529 540 DFRVLLTGTPLQNNLKELISLLAFILPHVFDY 571
Cdd:cd18054 176 NHRLLITGTPLQNSLKELWSLLHFIMPEKFEF 207
|
|
| DEXDc_SHPRH-like |
cd18008 |
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ... |
387-614 |
1.10e-40 |
|
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350766 [Multi-domain] Cd Length: 241 Bit Score: 150.13 E-value: 1.10e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 387 LQDYQIIGINWLyllyeLKLAGILADEMGLGKTCQTIA----------FFSLLMDKNINGPH--------LVIAPASTME 448
Cdd:cd18008 1 LLPYQKQGLAWM-----LPRGGILADEMGLGKTIQALAlilatrpqdpKIPEELEENSSDPKklylskttLIVVPLSLLS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 449 NWLREFAKFC--PKLKIELYYGSqvereeirERINSNKD--SYNVMLTTY-RLAA------------TSKADRLFLRNQK 511
Cdd:cd18008 76 QWKDEIEKHTkpGSLKVYVYHGS--------KRIKSIEElsDYDIVITTYgTLASefpknkkgggrdSKEKEASPLHRIR 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 512 FNVCVYDEGHYLKNRASERYRHLMSIPADFRVLLTGTPLQNNLKELISLLAFI-LPHVFDYGLKSLDVIFTMKKSPESDF 590
Cdd:cd18008 148 WYRVILDEAHNIKNRSTKTSRAVCALKAERRWCLTGTPIQNSLDDLYSLLRFLrVEPFGDYPWFNSDISKPFSKNDRKAL 227
|
250 260
....*....|....*....|....
gi 19114529 591 ERallsEQRVSRakmmmaPFVLRR 614
Cdd:cd18008 228 ER----LQALLK------PILLRR 241
|
|
| DEXHc_Mot1 |
cd17999 |
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in ... |
387-614 |
1.27e-40 |
|
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in eukaryotes) regulates transcription in association with TATA binding protein (TBP). Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals. Mot1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350757 [Multi-domain] Cd Length: 232 Bit Score: 149.42 E-value: 1.27e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 387 LQDYQIIGINWLYLLYELKLAGILADEMGLGKTCQTIAffSLLMD--------KNINGPHLVIAPASTMENWLREFAKFC 458
Cdd:cd17999 1 LRPYQQEGINWLAFLNKYNLHGILCDDMGLGKTLQTLC--ILASDhhkransfNSENLPSLVVCPPTLVGHWVAEIKKYF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 459 P--KLKIELYYGSQVEREEIRERINSNkdsyNVMLTTYrlaATSKADRLFLRNQKFNVCVYDEGHYLKNRASERYRHLMS 536
Cdd:cd17999 79 PnaFLKPLAYVGPPQERRRLREQGEKH----NVIVASY---DVLRNDIEVLTKIEWNYCVLDEGHIIKNSKTKLSKAVKQ 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 537 IPADFRVLLTGTPLQNNLKELISLLAFILP------HVF--DYG---LKSLDviftmKKSPESDFERALLSEQRVSRAKM 605
Cdd:cd17999 152 LKANHRLILSGTPIQNNVLELWSLFDFLMPgylgteKQFqrRFLkpiLASRD-----SKASAKEQEAGALALEALHKQVL 226
|
....*....
gi 19114529 606 mmaPFVLRR 614
Cdd:cd17999 227 ---PFLLRR 232
|
|
| DEXHc_CHD3_4_5 |
cd17994 |
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; ... |
387-614 |
6.54e-40 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD3, CHD4, and CHD5 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350752 [Multi-domain] Cd Length: 196 Bit Score: 146.05 E-value: 6.54e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 387 LQDYQIIGINWLYLLYELKLAGILADEMGLGKTCQTIAF-FSLLMDKNINGPHLVIAPASTMENWLREFAKFCPKLKIEL 465
Cdd:cd17994 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFlYSLYKEGHSKGPFLVSAPLSTIINWEREFEMWAPDFYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 466 YYGSqvereeirerinsnkdsyNVMLTTYRLAATSKAdrlFLRNQKFNVCVYDEGHYLKNRASERYRHLMSIPADFRVLL 545
Cdd:cd17994 81 YVGD------------------HVLLTSYELISIDQA---ILGSIDWAVLVVDEAHRLKNNQSKFFRILNSYKIGYKLLL 139
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19114529 546 TGTPLQNNLKELISLLAFILPHVFDYGLKSLDVIFTMKKspesdferallsEQRVSRAKMMMAPFVLRR 614
Cdd:cd17994 140 TGTPLQNNLEELFHLLNFLTPERFNNLQGFLEEFADISK------------EDQIKKLHDLLGPHMLRR 196
|
|
| DEXHc_SMARCA1 |
cd18065 |
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent ... |
387-616 |
9.37e-40 |
|
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (SMARCA1, also called SNF2L) is a component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes which promote the perturbation of chromatin structure in an ATP-dependent manner. SMARCA1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350823 [Multi-domain] Cd Length: 233 Bit Score: 147.09 E-value: 9.37e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 387 LQDYQIIGINWLYLLYELKLAGILADEMGLGKTCQTIAFFSLLMD-KNINGPHLVIAPASTMENWLREFAKFCPKLKIEL 465
Cdd:cd18065 16 LRDYQVRGLNWMISLYENGVNGILADEMGLGKTLQTIALLGYLKHyRNIPGPHMVLVPKSTLHNWMNEFKRWVPSLRAVC 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 466 YYGSQVEREE-IRERINSNKdsYNVMLTTYRLAATSKAdrLFlrnQKFN--VCVYDEGHYLKNRASERYRHLMSIPADFR 542
Cdd:cd18065 96 LIGDKDARAAfIRDVMMPGE--WDVCVTSYEMVIKEKS--VF---KKFNwrYLVIDEAHRIKNEKSKLSEIVREFKTTNR 168
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 19114529 543 VLLTGTPLQNNLKELISLLAFILPHVFDYGlKSLDVIFtmkkspesDFERALLSEQRVSRAKMMMAPFVLRRKK 616
Cdd:cd18065 169 LLLTGTPLQNNLHELWALLNFLLPDVFNSA-DDFDSWF--------DTKNCLGDQKLVERLHAVLKPFLLRRIK 233
|
|
| DEXHc_SMARCA2 |
cd18063 |
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent ... |
387-616 |
4.12e-39 |
|
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, also known as brahma homolog) is a component of the BAF complex. SMARCA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350821 [Multi-domain] Cd Length: 251 Bit Score: 145.98 E-value: 4.12e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 387 LQDYQIIGINWLYLLYELKLAGILADEMGLGKTCQTIAFFSLLMD-KNINGPHLVIAPASTMENWLREFAKFCPKLKIEL 465
Cdd:cd18063 24 LKHYQLQGLEWMVSLYNNNLNGILADEMGLGKTIQTIALITYLMEhKRLNGPYLIIVPLSTLSNWTYEFDKWAPSVVKIS 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 466 YYGSQVEREEIRERINSNKdsYNVMLTTYRLAATskaDRLFLRNQKFNVCVYDEGHYLKNRASERYRHLMS-IPADFRVL 544
Cdd:cd18063 104 YKGTPAMRRSLVPQLRSGK--FNVLLTTYEYIIK---DKHILAKIRWKYMIVDEGHRMKNHHCKLTQVLNThYVAPRRIL 178
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 19114529 545 LTGTPLQNNLKELISLLAFILPHVFdyglKSLDVIFTMKKSPES-DFERALLSEQR----VSRAKMMMAPFVLRRKK 616
Cdd:cd18063 179 LTGTPLQNKLPELWALLNFLLPTIF----KSCSTFEQWFNAPFAmTGERVDLNEEEtiliIRRLHKVLRPFLLRRLK 251
|
|
| DEXHc_SMARCA4 |
cd18062 |
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent ... |
387-616 |
7.29e-39 |
|
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4, also known as transcription activator BRG1) is a component of the CREST-BRG1 complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes, contributes to a range of malignancies and neurologic disorders. SMARCA4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350820 [Multi-domain] Cd Length: 251 Bit Score: 145.19 E-value: 7.29e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 387 LQDYQIIGINWLYLLYELKLAGILADEMGLGKTCQTIAFFSLLMD-KNINGPHLVIAPASTMENWLREFAKFCPKLKIEL 465
Cdd:cd18062 24 LKQYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTIALITYLMEhKRINGPFLIIVPLSTLSNWVYEFDKWAPSVVKVS 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 466 YYGSQVEREEIRERINSNKdsYNVMLTTYRLAATskaDRLFLRNQKFNVCVYDEGHYLKNRASERYRHLMS-IPADFRVL 544
Cdd:cd18062 104 YKGSPAARRAFVPQLRSGK--FNVLLTTYEYIIK---DKQILAKIRWKYMIVDEGHRMKNHHCKLTQVLNThYVAPRRLL 178
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 19114529 545 LTGTPLQNNLKELISLLAFILPHVFdyglKSLDVIFTMKKSPES-DFERALLSEQR----VSRAKMMMAPFVLRRKK 616
Cdd:cd18062 179 LTGTPLQNKLPELWALLNFLLPTIF----KSCSTFEQWFNAPFAmTGEKVDLNEEEtiliIRRLHKVLRPFLLRRLK 251
|
|
| DEXHc_CHD8 |
cd18060 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; ... |
387-614 |
1.05e-36 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; Chromodomain-helicase-DNA-binding protein 8 (CHD8) is a DNA helicase that acts as a chromatin remodeling factor and regulates transcription. It also acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. It suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity and of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. It also acts as a negative regulator of Wnt signaling pathway and CTNNB1-targeted gene expression. CHD8 is also involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. It also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. CHD8 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350818 [Multi-domain] Cd Length: 222 Bit Score: 137.88 E-value: 1.05e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 387 LQDYQIIGINWLYLLYELKLAGILADEMGLGKTCQTIAFFSLLMDKNINGPHLVIAPASTMENWLREFAKFCpKLKIELY 466
Cdd:cd18060 1 LREYQLEGVNWLLFNWYNRQNCILADEMGLGKTIQSIAFLQEVYNVGIHGPFLVIAPLSTITNWEREFNTWT-EMNTIVY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 467 YGSQVEREEIRERINSNKDS----------YNVMLTTYRLAATSKADrlfLRNQKFNVCVYDEGHYLKNRASERYRHLMS 536
Cdd:cd18060 80 HGSLASRQMIQQYEMYCKDSrgrlipgaykFDALITTFEMILSDCPE---LREIEWRCVIIDEAHRLKNRNCKLLDSLKH 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 537 IPADFRVLLTGTPLQNNLKELISLLAFILPHVFdyglksldviftmkkSPESDFERA---LLSEQRVSRAKMMMAPFVLR 613
Cdd:cd18060 157 MDLEHKVLLTGTPLQNTVEELFSLLHFLEPSQF---------------PSESEFLKDfgdLKTEEQVQKLQAILKPMMLR 221
|
.
gi 19114529 614 R 614
Cdd:cd18060 222 R 222
|
|
| DEXHc_CHD6 |
cd18058 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; ... |
387-614 |
3.18e-36 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6 (CHD6) is a DNA-dependent ATPase that plays a role in chromatin remodeling. It regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. It activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.2 and acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. CHD6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350816 [Multi-domain] Cd Length: 222 Bit Score: 136.71 E-value: 3.18e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 387 LQDYQIIGINWLYLLYELKLAGILADEMGLGKTCQTIAFFSLLMDKNINGPHLVIAPASTMENWLREFAKFCpKLKIELY 466
Cdd:cd18058 1 LREYQLEGMNWLLFNWYNRKNCILADEMGLGKTIQSITFLSEIFLMGIRGPFLIIAPLSTITNWEREFRTWT-EMNAIVY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 467 YGSQVEREEIRERINSNKDS----------YNVMLTTYRLAAtskADRLFLRNQKFNVCVYDEGHYLKNRASERYRHLMS 536
Cdd:cd18058 80 HGSQISRQMIQQYEMYYRDEqgnplsgifkFQVVITTFEMIL---ADCPELKKINWSCVIIDEAHRLKNRNCKLLEGLKL 156
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19114529 537 IPADFRVLLTGTPLQNNLKELISLLAFILPHVFDYGLKSLDVIFTMKkspesdferallSEQRVSRAKMMMAPFVLRR 614
Cdd:cd18058 157 MALEHKVLLTGTPLQNSVEELFSLLNFLEPSQFPSETTFLEEFGDLK------------TEEQVKKLQSILKPMMLRR 222
|
|
| DEXHc_CHD5 |
cd18057 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; ... |
387-614 |
1.08e-35 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350815 [Multi-domain] Cd Length: 232 Bit Score: 135.19 E-value: 1.08e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 387 LQDYQIIGINWLYLLYELKLAGILADEMGLGKTCQTIAF-FSLLMDKNINGPHLVIAPASTMENWLREFAKFCPKLKIEL 465
Cdd:cd18057 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTIVFlYSLYKEGHSKGPYLVSAPLSTIINWEREFEMWAPDFYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 466 YYGSQVEREEIRERINSNKDS------------------YNVMLTTYRLAATskaDRLFLRNQKFNVCVYDEGHYLKNRA 527
Cdd:cd18057 81 YTGDKESRSVIRENEFSFEDNairsgkkvfrmkkeaqikFHVLLTSYELITI---DQAILGSIEWACLVVDEAHRLKNNQ 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 528 SERYRHLMSIPADFRVLLTGTPLQNNLKELISLLAFILPHVFDYGLKSLDVIFTMKKspesdferallsEQRVSRAKMMM 607
Cdd:cd18057 158 SKFFRVLNSYKIDYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFADISK------------EDQIKKLHDLL 225
|
....*..
gi 19114529 608 APFVLRR 614
Cdd:cd18057 226 GPHMLRR 232
|
|
| DEXHc_CHD7 |
cd18059 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; ... |
387-614 |
1.16e-35 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; Chromodomain-helicase-DNA-binding protein 7 (CHD7) is a probable transcription regulator. It may be involved in the 45S precursor rRNA production. CHD7 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350817 [Multi-domain] Cd Length: 222 Bit Score: 134.77 E-value: 1.16e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 387 LQDYQIIGINWLYLLYELKLAGILADEMGLGKTCQTIAFFSLLMDKNINGPHLVIAPASTMENWLREFAKFCpKLKIELY 466
Cdd:cd18059 1 LREYQLEGVNWLLFNWYNTRNCILADEMGLGKTIQSITFLYEIYLKGIHGPFLVIAPLSTIPNWEREFRTWT-ELNVVVY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 467 YGSQVEREEIRE----------RINSNKDSYNVMLTTYRLAATSKADrlfLRNQKFNVCVYDEGHYLKNRASERYRHLMS 536
Cdd:cd18059 80 HGSQASRRTIQLyemyfkdpqgRVIKGSYKFHAIITTFEMILTDCPE---LRNIPWRCVVIDEAHRLKNRNCKLLEGLKM 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 537 IPADFRVLLTGTPLQNNLKELISLLAFILPHVFdyglksldviftmkkSPESDFERA---LLSEQRVSRAKMMMAPFVLR 613
Cdd:cd18059 157 MDLEHKVLLTGTPLQNTVEELFSLLHFLEPSRF---------------PSETTFMQEfgdLKTEEQVQKLQAILKPMMLR 221
|
.
gi 19114529 614 R 614
Cdd:cd18059 222 R 222
|
|
| DEXHc_CHD1 |
cd18053 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; ... |
385-569 |
3.21e-35 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350811 [Multi-domain] Cd Length: 237 Bit Score: 134.02 E-value: 3.21e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 385 IKLQDYQIIGINWLYLLYELKLAGILADEMGLGKTCQTIAFFSLLM-DKNINGPHLVIAPASTMENWLREFAKFCPKLKI 463
Cdd:cd18053 19 LELRDYQLNGLNWLAHSWCKGNSCILADEMGLGKTIQTISFLNYLFhEHQLYGPFLLVVPLSTLTSWQREIQTWAPQMNA 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 464 ELYYGSQVEREEIRER----INSNKDSYNVMLTTYRLAATskaDRLFLRNQKFNVCVYDEGHYLKNRASERYRHLMSIPA 539
Cdd:cd18053 99 VVYLGDINSRNMIRTHewmhPQTKRLKFNILLTTYEILLK---DKSFLGGLNWAFIGVDEAHRLKNDDSLLYKTLIDFKS 175
|
170 180 190
....*....|....*....|....*....|
gi 19114529 540 DFRVLLTGTPLQNNLKELISLLAFILPHVF 569
Cdd:cd18053 176 NHRLLITGTPLQNSLKELWSLLHFIMPEKF 205
|
|
| DEXHc_CHD3 |
cd18055 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; ... |
387-570 |
3.50e-35 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. CHD3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350813 [Multi-domain] Cd Length: 232 Bit Score: 133.98 E-value: 3.50e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 387 LQDYQIIGINWLYLLYELKLAGILADEMGLGKTCQTIAF-FSLLMDKNINGPHLVIAPASTMENWLREFAKFCPKLKIEL 465
Cdd:cd18055 1 LHMYQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFlYSLYKEGHTKGPFLVSAPLSTIINWEREFQMWAPDFYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 466 YYGSQVEREEIRERINSNKDS------------------YNVMLTTYRLAATskaDRLFLRNQKFNVCVYDEGHYLKNRA 527
Cdd:cd18055 81 YTGDKDSRAIIRENEFSFDDNavkggkkafkmkreaqvkFHVLLTSYELVTI---DQAALGSIRWACLVVDEAHRLKNNQ 157
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 19114529 528 SERYRHLMSIPADFRVLLTGTPLQNNLKELISLLAFILPHVFD 570
Cdd:cd18055 158 SKFFRVLNGYKIDHKLLLTGTPLQNNLEELFHLLNFLTPERFN 200
|
|
| DEXHc_RAD54 |
cd18004 |
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ... |
387-614 |
4.86e-33 |
|
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350762 [Multi-domain] Cd Length: 240 Bit Score: 127.79 E-value: 4.86e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 387 LQDYQIIGINWLY--LLYELKLAG---ILADEMGLGKTCQTIAFFSLLMDKNINGPH-----LVIAPASTMENWLREFAK 456
Cdd:cd18004 1 LRPHQREGVQFLYdcLTGRRGYGGggaILADEMGLGKTLQAIALVWTLLKQGPYGKPtakkaLIVCPSSLVGNWKAEFDK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 457 FCP--KLKIELYYGSQVEREEIRERINSNKDsYNVMLTTYRLAATSkADRLfLRNQKFNVCVYDEGHYLKNRASERYRHL 534
Cdd:cd18004 81 WLGlrRIKVVTADGNAKDVKASLDFFSSAST-YPVLIISYETLRRH-AEKL-SKKISIDLLICDEGHRLKNSESKTTKAL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 535 MSIPADFRVLLTGTPLQNNLKELISLLAFILPHVfdygLKSLDV---IFT----MKKSPESDFERALLSEQRVSRAKMMM 607
Cdd:cd18004 158 NSLPCRRRLLLTGTPIQNDLDEFFALVDFVNPGI----LGSLASfrkVFEepilRSRDPDASEEDKELGAERSQELSELT 233
|
....*..
gi 19114529 608 APFVLRR 614
Cdd:cd18004 234 SRFILRR 240
|
|
| DEXHc_ERCC6L2 |
cd18005 |
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ... |
387-614 |
6.99e-32 |
|
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350763 [Multi-domain] Cd Length: 245 Bit Score: 124.80 E-value: 6.99e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 387 LQDYQIIGINWLYLLYELKLAGILADEMGLGKTCQTIAFFSLLMDK---------------------NINGPHLVIAPAS 445
Cdd:cd18005 1 LRDYQREGVEFMYDLYKNGRGGILGDDMGLGKTVQVIAFLAAVLGKtgtrrdrennrprfkkkppasSAKKPVLIVAPLS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 446 TMENWLREFAKFcPKLKIELYYGSQveREEIRE-RINSNKdsYNVMLTTYRLAATSKADrlfLRNQKFNVCVYDEGHYLK 524
Cdd:cd18005 81 VLYNWKDELDTW-GHFEVGVYHGSR--KDDELEgRLKAGR--LEVVVTTYDTLRRCIDS---LNSINWSAVIADEAHRIK 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 525 NRASERYRHLMSIPADFRVLLTGTPLQNNLKELISLLAFILPHVF----DYGLKSLDVIFTMKKSPESDFERAlLSEQRV 600
Cdd:cd18005 153 NPKSKLTQAMKELKCKVRIGLTGTLLQNNMKELWCLLDWAVPGALgsrsQFKKHFSEPIKRGQRHTATARELR-LGRKRK 231
|
250
....*....|....
gi 19114529 601 SRAKMMMAPFVLRR 614
Cdd:cd18005 232 QELAVKLSKFFLRR 245
|
|
| DEXHc_ATRX-like |
cd18007 |
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ... |
409-604 |
9.61e-32 |
|
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350765 [Multi-domain] Cd Length: 239 Bit Score: 124.33 E-value: 9.61e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 409 ILADEMGLGKTCQTIAFFSLLMDKNINGPH-LVIAPASTMENWLREFAKFCPKLKIE---LYYGSQVEREEIRER-INSN 483
Cdd:cd18007 30 ILAHTMGLGKTLQVITFLHTYLAAAPRRSRpLVLCPASTLYNWEDEFKKWLPPDLRPllvLVSLSASKRADARLRkINKW 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 484 KDSYNVMLTTY----RLAATSKAD-RLFLRNQKF------NVCVYDEGHYLKNRASERYRHLMSIPADFRVLLTGTPLQN 552
Cdd:cd18007 110 HKEGGVLLIGYelfrNLASNATTDpRLKQEFIAAlldpgpDLLVLDEGHRLKNEKSQLSKALSKVKTKRRILLTGTPLQN 189
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 19114529 553 NLKELISLLAFILPhvfDYgLKSLDVIFTMKKSP--ESDFERALLSEQRVSRAK 604
Cdd:cd18007 190 NLKEYWTMVDFARP---KY-LGTLKEFKKKFVKPieAGQCVDSTEEDVRLMLKR 239
|
|
| DEXHc_CHD4 |
cd18056 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; ... |
387-614 |
1.07e-31 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. CHD4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350814 [Multi-domain] Cd Length: 232 Bit Score: 124.02 E-value: 1.07e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 387 LQDYQIIGINWLYLLYELKLAGILADEMGLGKTCQTIAF-FSLLMDKNINGPHLVIAPASTMENWLREFAKFCPKLKIEL 465
Cdd:cd18056 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTAVFlYSLYKEGHSKGPFLVSAPLSTIINWEREFEMWAPDMYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 466 YYGSQVEREEIRERINSNKDS------------------YNVMLTTYRLAATskaDRLFLRNQKFNVCVYDEGHYLKNRA 527
Cdd:cd18056 81 YVGDKDSRAIIRENEFSFEDNairggkkasrmkkeasvkFHVLLTSYELITI---DMAILGSIDWACLIVDEAHRLKNNQ 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 528 SERYRHLMSIPADFRVLLTGTPLQNNLKELISLLAFILPHVFDYGLKSLDVIFTMKKspesdferallsEQRVSRAKMMM 607
Cdd:cd18056 158 SKFFRVLNGYSLQHKLLLTGTPLQNNLEELFHLLNFLTPERFHNLEGFLEEFADIAK------------EDQIKKLHDML 225
|
....*..
gi 19114529 608 APFVLRR 614
Cdd:cd18056 226 GPHMLRR 232
|
|
| DEXHc_CHD9 |
cd18061 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; ... |
387-614 |
3.42e-31 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; Chromodomain-helicase-DNA-binding protein 9 (CHD9) acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. It is proposed to be a ATP-dependent chromatin remodeling protein. CHD9 has DNA-dependent ATPase activity and binds to A/T-rich DNA. It also associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis. CHD9 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350819 [Multi-domain] Cd Length: 222 Bit Score: 122.04 E-value: 3.42e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 387 LQDYQIIGINWLYLLYELKLAGILADEMGLGKTCQTIAFFSLLMDKNINGPHLVIAPASTMENWLREFAKFCpKLKIELY 466
Cdd:cd18061 1 LREYQLEGLNWLLFNWYNRRNCILADEMGLGKTIQSITFLYEILLTGIRGPFLIIAPLSTIANWEREFRTWT-DLNVVVY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 467 YGSQVEREEIRERINSNKDSYN-VMLTTYRLAATSKADRLF------LRNQKFNVCVYDEGHYLKNRASERYRHLMSIPA 539
Cdd:cd18061 80 HGSLISRQMIQQYEMYFRDSQGrIIRGAYRFQAIITTFEMIlggcpeLNAIDWRCVIIDEAHRLKNKNCKLLEGLKLMNL 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19114529 540 DFRVLLTGTPLQNNLKELISLLAFILPHVFdyglksldviftmkkSPESDFERA---LLSEQRVSRAKMMMAPFVLRR 614
Cdd:cd18061 160 EHKVLLTGTPLQNTVEELFSLLHFLEPLRF---------------PSESTFMQEfgdLKTEEQVQKLQAILKPMMLRR 222
|
|
| DEXHc_RAD54B |
cd18066 |
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as ... |
387-614 |
3.05e-28 |
|
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as RDH54, binds to double-stranded DNA, displays ATPase activity in the presence of DNA, and may have a role in meiotic and mitotic recombination. RAD54B is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350824 [Multi-domain] Cd Length: 235 Bit Score: 113.79 E-value: 3.05e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 387 LQDYQIIGINWLY-----LLYELKLAGILADEMGLGKTCQTIAFFSLLMDKNINGPH------LVIAPASTMENWLREFA 455
Cdd:cd18066 1 LRPHQREGIEFLYecvmgMRVNERFGAILADEMGLGKTLQCISLIWTLLRQGPYGGKpvikraLIVTPGSLVKNWKKEFQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 456 KFCPKLKIELYYGSQveREEIRERINSNkdSYNVMLTTYRLAATSKADrlfLRNQKFNVCVYDEGHYLKNRASERYRHLM 535
Cdd:cd18066 81 KWLGSERIKVFTVDQ--DHKVEEFIASP--LYSVLIISYEMLLRSLDQ---ISKLNFDLVICDEGHRLKNTSIKTTTALT 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 536 SIPADFRVLLTGTPLQNNLKELISLLAFILPHVFDyGLKSLDVIF----TMKKSPESDFERALLSEQRVSRAKMMMAPFV 611
Cdd:cd18066 154 SLSCERRIILTGTPIQNDLQEFFALIDFVNPGILG-SLSTYRKVYeepiVRSREPTATPEEKKLGEARAAELTRLTGLFI 232
|
...
gi 19114529 612 LRR 614
Cdd:cd18066 233 LRR 235
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
385-566 |
1.73e-25 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 104.88 E-value: 1.73e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 385 IKLQDYQIIGINWLYllyELKLAGILADEMGLGKTCQTIAFFSLLMDKNINGPHLVIAP-ASTMENWLREFAKFCPKLKI 463
Cdd:smart00487 7 EPLRPYQKEAIEALL---SGLRDVILAAPTGSGKTLAALLPALEALKRGKGGRVLVLVPtRELAEQWAEELKKLGPSLGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 464 E--LYYGSQVEREEIRERINSNkdsYNVMLTTY-RLAATSKADRLFLRNqkFNVCVYDEGHYLKNRA-SERYRHLMS--I 537
Cdd:smart00487 84 KvvGLYGGDSKREQLRKLESGK---TDILVTTPgRLLDLLENDKLSLSN--VDLVILDEAHRLLDGGfGDQLEKLLKllP 158
|
170 180 190
....*....|....*....|....*....|..
gi 19114529 538 PADFRVLLTGTP---LQNNLKELISLLAFILP 566
Cdd:smart00487 159 KNVQLLLLSATPpeeIENLLELFLNDPVFIDV 190
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
762-874 |
1.64e-23 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 96.13 E-value: 1.64e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 762 KVRKLKKLLtnAVENGDRVVLFSQFTQVLDIlQLVMKSLNLKFLRFDGSTQVDFRQDLIDQFYADESInvFLLSTKAGGF 841
Cdd:pfam00271 2 KLEALLELL--KKERGGKVLIFSQTKKTLEA-ELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKID--VLVATDVAER 76
|
90 100 110
....*....|....*....|....*....|...
gi 19114529 842 GINLACANMVILYDVSFNPFDDLQAEDRAHRVG 874
Cdd:pfam00271 77 GLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEXHc_HLTF1_SMARC3 |
cd18071 |
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as ... |
403-564 |
8.27e-23 |
|
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as HIP116 or SMARCA3) has both helicase and E3 ubiquitin ligase activities and ATP-dependent nucleosome-remodeling activity. HLTF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350829 [Multi-domain] Cd Length: 239 Bit Score: 98.31 E-value: 8.27e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 403 ELKLAGILADEMGLGKTCQTIAFfsLLMDKNingphLVIAPASTMENWLREFAKFCPK--LKIELYYGSQvereeiRERI 480
Cdd:cd18071 46 ELVRGGILADDMGLGKTLTTISL--ILANFT-----LIVCPLSVLSNWETQFEEHVKPgqLKVYTYHGGE------RNRD 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 481 NSNKDSYNVMLTTYRLAAT--SKADRLFLRNQKFNVCVYDEGHYLKNRASERYRHLMSIPADFRVLLTGTPLQNNLKELI 558
Cdd:cd18071 113 PKLLSKYDIVLTTYNTLASdfGAKGDSPLHTINWLRVVLDEGHQIRNPNAQQTKAVLNLSSERRWVLTGTPIQNSPKDLG 192
|
....*.
gi 19114529 559 SLLAFI 564
Cdd:cd18071 193 SLLSFL 198
|
|
| DEXHc_HARP_SMARCAL1 |
cd18010 |
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ... |
409-571 |
9.88e-23 |
|
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350768 [Multi-domain] Cd Length: 213 Bit Score: 97.28 E-value: 9.88e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 409 ILADEMGLGKTCQTIAFFSLLMDkniNGPHLVIAPASTMENWLREFAKFCPKLKIElyygsqvereEIReRINSNKDSYN 488
Cdd:cd18010 20 LIADEMGLGKTVQAIAIAAYYRE---EWPLLIVCPSSLRLTWADEIERWLPSLPPD----------DIQ-VIVKSKDGLR 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 489 -----VMLTTYRLAATSKADrlfLRNQKFNVCVYDEGHYLKNRASERYRHLMSI--PADFRVLLTGTPLQNNLKELISLL 561
Cdd:cd18010 86 dgdakVVIVSYDLLRRLEKQ---LLARKFKVVICDESHYLKNSKAKRTKAALPLlkRAKRVILLSGTPALSRPIELFTQL 162
|
170
....*....|
gi 19114529 562 AFILPHVFDY 571
Cdd:cd18010 163 DALDPKLFGR 172
|
|
| DEXHc_ATRX |
cd18068 |
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha ... |
387-566 |
1.50e-21 |
|
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350826 [Multi-domain] Cd Length: 246 Bit Score: 94.95 E-value: 1.50e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 387 LQDYQIIGINWLY------LLYELKLAG---ILADEMGLGKTCQTIAFF-SLLMDKNINGPH--LVIAPASTMENWLREF 454
Cdd:cd18068 1 LKPHQVDGVQFMWdcccesLKKTKKSPGsgcILAHCMGLGKTLQVVTFLhTVLLCEKLENFSrvLVVCPLNTVLNWLNEF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 455 AKFCPKLK----IELYYGSQVEREEIRE-RINSNKDSYNVMLTTY---RLAATSKADRL----------FLRNQKFNVCV 516
Cdd:cd18068 81 EKWQEGLKdeekIEVNELATYKRPQERSyKLQRWQEEGGVMIIGYdmyRILAQERNVKSreklkeifnkALVDPGPDFVV 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 19114529 517 YDEGHYLKNRASERYRHLMSIPADFRVLLTGTPLQNNLKELISLLAFILP 566
Cdd:cd18068 161 CDEGHILKNEASAVSKAMNSIRTKRRIVLTGTPLQNNLIEYHCMVNFVKP 210
|
|
| DEXDc_RapA |
cd18011 |
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated ... |
409-570 |
5.96e-20 |
|
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350769 [Multi-domain] Cd Length: 207 Bit Score: 89.27 E-value: 5.96e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 409 ILADEMGLGKTCQTIAFFSLLMDKNINGPHLVIAPASTMENWLRE-FAKFcpKLKIELYYGSQVEReeIRERINSNKDSY 487
Cdd:cd18011 21 LLADEVGLGKTIEAGLIIKELLLRGDAKRVLILCPASLVEQWQDElQDKF--GLPFLILDRETAAQ--LRRLIGNPFEEF 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 488 NVMLTTYRLAATSKADRLFLRNQKFNVCVYDEGHYLKNRA----SERYRHLMSIPADFR--VLLTGTPLQNNLKELISLL 561
Cdd:cd18011 97 PIVIVSLDLLKRSEERRGLLLSEEWDLVVVDEAHKLRNSGggkeTKRYKLGRLLAKRARhvLLLTATPHNGKEEDFRALL 176
|
....*....
gi 19114529 562 AFILPHVFD 570
Cdd:cd18011 177 SLLDPGRFA 185
|
|
| DEXHc_RAD54A |
cd18067 |
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as ... |
387-566 |
8.89e-20 |
|
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as RAD54L or RAD54, plays a role in homologous recombination related repair of DNA double-strand breaks. RAD54A is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350825 [Multi-domain] Cd Length: 243 Bit Score: 89.45 E-value: 8.89e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 387 LQDYQIIGINWLYLLYELKLAG-----ILADEMGLGKTCQTIAF-FSLLMDKNINGPHL----VIAPASTMENWLREFAK 456
Cdd:cd18067 1 LRPHQREGVKFLYRCVTGRRIRgshgcIMADEMGLGKTLQCITLmWTLLRQSPQCKPEIdkaiVVSPSSLVKNWANELGK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 457 FCPKLKIELYYGSQVEREEIRERINS-NKDSYN----VMLTTYRlaaTSKADRLFLRNQKFNVCVYDEGHYLKNRASERY 531
Cdd:cd18067 81 WLGGRLQPLAIDGGSKKEIDRKLVQWaSQQGRRvstpVLIISYE---TFRLHVEVLQKGEVGLVICDEGHRLKNSDNQTY 157
|
170 180 190
....*....|....*....|....*....|....*
gi 19114529 532 RHLMSIPADFRVLLTGTPLQNNLKELISLLAFILP 566
Cdd:cd18067 158 QALDSLNTQRRVLLSGTPIQNDLSEYFSLVNFVNP 192
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
791-874 |
2.12e-19 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 83.42 E-value: 2.12e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 791 DILQLVMKSLNLKFLRFDGSTQVDFRQDLIDQFYADEsiNVFLLSTKAGGFGINLACANMVILYDVSFNPFDDLQAEDRA 870
Cdd:smart00490 1 EELAELLKELGIKVARLHGGLSQEEREEILDKFNNGK--IKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRA 78
|
....
gi 19114529 871 HRVG 874
Cdd:smart00490 79 GRAG 82
|
|
| DEXHc_ARIP4 |
cd18069 |
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called ... |
387-566 |
7.20e-19 |
|
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called RAD54 like 2 or RAD54L2 ) modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. ARIP4 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350827 [Multi-domain] Cd Length: 227 Bit Score: 86.41 E-value: 7.20e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 387 LQDYQIIGINWLY-----LLYELK----LAGILADEMGLGKTCQTIAFFSLLMDKNINGPHLVIAPASTMENWLREFAKF 457
Cdd:cd18069 1 LKPHQIGGIRFLYdniieSLERYKgssgFGCILAHSMGLGKTLQVISFLDVLLRHTGAKTVLAIVPVNTLQNWLSEFNKW 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 458 CPK-----------LKIELYYGSQVEREEIRERINSNKDSYNVMLTTYrlaatskadRLFLRNQKFNVCVYDEGHYLKNR 526
Cdd:cd18069 81 LPPpealpnvrprpFKVFILNDEHKTTAARAKVIEDWVKDGGVLLMGY---------EMFRLRPGPDVVICDEGHRIKNC 151
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 19114529 527 ASERYRHLMSIPADFRVLLTGTPLQNNLKELISLLAFILP 566
Cdd:cd18069 152 HASTSQALKNIRSRRRIVLTGYPLQNNLIEYWCMVDFVRP 191
|
|
| DEXHc_TTF2 |
cd18072 |
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called ... |
408-570 |
2.20e-18 |
|
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called Forkhead-box E1/FOXE1 ) is a transcription termination factor that couples ATP hydrolysis with the removal of RNA polymerase II from the DNA template. Single nucleotide polymorphism (SNP) within the 5'-UTR of TTF2 is associated with thyroid cancer risk.TTF2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350830 [Multi-domain] Cd Length: 241 Bit Score: 85.61 E-value: 2.20e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 408 GILADEMGLGKTCQTIAffSLLMDKN-------------------------INGPHLVIAPASTMENWLREFAKFCP--K 460
Cdd:cd18072 23 GILADDMGLGKTLTMIA--LILAQKNtqnrkeeekekalteweskkdstlvPSAGTLVVCPASLVHQWKNEVESRVAsnK 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 461 LKIELYYGSQvereeiRERINSNKDSYNVMLTTYRLAA----TSKADRLF--LRNQKFNVCVYDEGHYLKNRASERYRHL 534
Cdd:cd18072 101 LRVCLYHGPN------RERIGEVLRDYDIVITTYSLVAkeipTYKEESRSspLFRIAWARIILDEAHNIKNPKVQASIAV 174
|
170 180 190
....*....|....*....|....*....|....*.
gi 19114529 535 MSIPADFRVLLTGTPLQNNLKELISLLAFILPHVFD 570
Cdd:cd18072 175 CKLRAHARWALTGTPIQNNLLDMYSLLKFLRCSPFD 210
|
|
| DEXQc_bact_SNF2 |
cd18013 |
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 ... |
387-572 |
8.54e-12 |
|
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprise a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. The bacterial SNF2 present in this family are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350771 [Multi-domain] Cd Length: 218 Bit Score: 65.45 E-value: 8.54e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 387 LQDYQIIGINWLYllyELKLAGILADeMGLGKTCQTIAFFSLLMDKNINGPHLVIAPASTMEN-WLREFAKFcpKLKIEL 465
Cdd:cd18013 1 PHPYQKVAINFII---EHPYCGLFLD-MGLGKTVTTLTALSDLQLDDFTRRVLVIAPLRVARStWPDEVEKW--NHLRNL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 466 YYGSQVEREeiRERINSNKDSYNVMLTTYRLaaTSKADRLFLRNQKFNVCVYDEGHYLKNRASERYRHLMSIPADFR--V 543
Cdd:cd18013 75 TVSVAVGTE--RQRSKAANTPADLYVINREN--LKWLVNKSGDPWPFDMVVIDELSSFKSPRSKRFKALRKVRPVIKrlI 150
|
170 180
....*....|....*....|....*....
gi 19114529 544 LLTGTPLQNNLKELISLLAFIlphvfDYG 572
Cdd:cd18013 151 GLTGTPSPNGLMDLWAQIALL-----DQG 174
|
|
| DEXQc_SHPRH |
cd18070 |
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously ... |
387-597 |
1.96e-11 |
|
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously expressed protein that contains motifs characteristic of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 and is involved in DNA repair. SHPRH is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350828 [Multi-domain] Cd Length: 257 Bit Score: 65.44 E-value: 1.96e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 387 LQDYQIIGINWLyllyeLKLAGILADEMGLGKTCQTIAFfsLLMDKNINGPH---------------------------- 438
Cdd:cd18070 1 LLPYQRRAVNWM-----LVPGGILADEMGLGKTVEVLAL--ILLHPRPDNDLdaadddsdemvccpdclvaetpvsskat 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 439 LVIAPASTMENWLREFAKFCPK-LKIELYYG---SQVEREEIRERINsnkdSYNVMLTTYR-LA-----ATSKADRLFLR 508
Cdd:cd18070 74 LIVCPSAILAQWLDEINRHVPSsLKVLTYQGvkkDGALASPAPEILA----EYDIVVTTYDvLRtelhyAEANRSNRRRR 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 509 NQK--------------FNVCVyDEGHYLKNRASERYRHLMSIPADFRVLLTGTPLQNNLKELISLLAFILPHVFDYGLK 574
Cdd:cd18070 150 RQKryeappsplvlvewWRVCL-DEAQMVESSTSKAAEMARRLPRVNRWCVSGTPIQRGLDDLFGLLSFLGVEPFCDSDW 228
|
250 260
....*....|....*....|....
gi 19114529 575 SLDVIFTMKKSPE-SDFERALLSE 597
Cdd:cd18070 229 WARVLIRPQGRNKaREPLAALLKE 252
|
|
| ResIII |
pfam04851 |
Type III restriction enzyme, res subunit; |
384-549 |
1.17e-08 |
|
Type III restriction enzyme, res subunit;
Pssm-ID: 398492 [Multi-domain] Cd Length: 162 Bit Score: 54.99 E-value: 1.17e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 384 DIKLQDYQIIGI-NWLYLLYELKLAGILADEMGLGKTCQTIAFFSLLMDKNINGPHLVIAP-ASTMENWLREFAKF--CP 459
Cdd:pfam04851 1 KLELRPYQIEAIeNLLESIKNGQKRGLIVMATGSGKTLTAAKLIARLFKKGPIKKVLFLVPrKDLLEQALEEFKKFlpNY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 460 KLKIELYYGsqvereeirERINSNKDSYNVMLTTY-RLAATSKADRLFLRNQKFNVCVYDEGHYLknrASERYRHLM-SI 537
Cdd:pfam04851 81 VEIGEIISG---------DKKDESVDDNKIVVTTIqSLYKALELASLELLPDFFDVIIIDEAHRS---GASSYRNILeYF 148
|
170
....*....|..
gi 19114529 538 PADFRVLLTGTP 549
Cdd:pfam04851 149 KPAFLLGLTATP 160
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
382-634 |
2.24e-08 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 57.73 E-value: 2.24e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 382 SPDIKLQDYQIIGIN-WLYLLYELKLAGILADEMGLGKTcqtiAFFSLLMDKNINGPH-LVIAPAST-MENWLREFAKFc 458
Cdd:COG1061 76 GTSFELRPYQQEALEaLLAALERGGGRGLVVAPTGTGKT----VLALALAAELLRGKRvLVLVPRRElLEQWAEELRRF- 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 459 pkLKIELYYGsqvereeireriNSNKDSYNVMLTTYRLAATSKADRLFLRNqkFNVCVYDEGHYLknrASERYRHLMS-I 537
Cdd:COG1061 151 --LGDPLAGG------------GKKDSDAPITVATYQSLARRAHLDELGDR--FGLVIIDEAHHA---GAPSYRRILEaF 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 538 PADFRVLLTGTPLQNNLKELisLLAFILPHVFDYGLKSL-------DVIFTMKKSPESDFERALLSEQRVSRAKMMMAPF 610
Cdd:COG1061 212 PAAYRLGLTATPFRSDGREI--LLFLFDGIVYEYSLKEAiedgylaPPEYYGIRVDLTDERAEYDALSERLREALAADAE 289
|
250 260
....*....|....*....|....
gi 19114529 611 VLRRKKSQVLDALPKKTRIIEFCE 634
Cdd:COG1061 290 RKDKILRELLREHPDDRKTLVFCS 313
|
|
| SF2_C_FANCM_Hef |
cd18801 |
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M ... |
762-882 |
2.40e-04 |
|
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. It is required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. FANCM and Hef are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350188 [Multi-domain] Cd Length: 143 Bit Score: 42.34 E-value: 2.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 762 KVRKLKKLLTNAVENGD-----RVVLFSQFTQ-VLDILQLVMK-SLNLKFLRF---------DGSTQVDfRQDLIDQFyA 825
Cdd:cd18801 10 KLEKLEEIVKEHFKKKQegsdtRVIIFSEFRDsAEEIVNFLSKiRPGIRATRFigqasgkssKGMSQKE-QKEVIEQF-R 87
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 19114529 826 DESINVfLLSTKAGGFGINLACANMVILYDVSFNPFDDLQaedRAHRVGQKKEVTVY 882
Cdd:cd18801 88 KGGYNV-LVATSIGEEGLDIGEVDLIICYDASPSPIRMIQ---RMGRTGRKRQGRVV 140
|
|
| SF2_C_XPB |
cd18789 |
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex ... |
758-852 |
3.33e-04 |
|
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex helicase XPB (xeroderma pigmentosum type B) subunit (also known as DNA excision repair protein ERCC-3 or TFIIH 89 kDa subunit) is the ATP-dependent 3'-5' DNA helicase component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. XPB is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350176 [Multi-domain] Cd Length: 153 Bit Score: 41.85 E-value: 3.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114529 758 MDATKVRKLKKLLTNAvENGDRVVLFSQFtqvLDILQLVMKSLNLKFLrfDGSTQVDFRQDLIDQFyADESINVFLLStK 837
Cdd:cd18789 31 MNPNKLRALEELLKRH-EQGDKIIVFTDN---VEALYRYAKRLLKPFI--TGETPQSEREEILQNF-REGEYNTLVVS-K 102
|
90
....*....|....*
gi 19114529 838 AGGFGINLACANMVI 852
Cdd:cd18789 103 VGDEGIDLPEANVAI 117
|
|
| |
