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Conserved domains on  [gi|19115279|ref|NP_594367|]
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leucine-rich repeat-containing protein [Schizosaccharomyces pombe]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
339-463 3.02e-19

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 90.38  E-value: 3.02e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115279 339 CSSCKLKSIPKNvFLSLQSLVSLDLSGNELTEIPYALGELPQLCSLNLASNKITgcrtfyHIS-----LSHLQILVLSRN 413
Cdd:COG4886 166 LSNNQLTDLPEE-LGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLT------DLPeplanLTNLETLDLSNN 238

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 19115279 414 HLTSLSGLENVPSLEKLDIRDNSITDVVEFRRLvgnTNFEEAYLSLNPFT 463
Cdd:COG4886 239 QLTDLPELGNLTNLEELDLSNNQLTDLPPLANL---TNLKTLDLSNNQLT 285
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
339-463 3.02e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 90.38  E-value: 3.02e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115279 339 CSSCKLKSIPKNvFLSLQSLVSLDLSGNELTEIPYALGELPQLCSLNLASNKITgcrtfyHIS-----LSHLQILVLSRN 413
Cdd:COG4886 166 LSNNQLTDLPEE-LGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLT------DLPeplanLTNLETLDLSNN 238

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 19115279 414 HLTSLSGLENVPSLEKLDIRDNSITDVVEFRRLvgnTNFEEAYLSLNPFT 463
Cdd:COG4886 239 QLTDLPELGNLTNLEELDLSNNQLTDLPPLANL---TNLKTLDLSNNQLT 285
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 343-470 1.56e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 64.42  E-value: 1.56e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115279 343 KLKSIPKnvFLSLQSLVSLDLSGNELTEIPYaLGELPQLCSLNLASNKIT-----------------------------G 393
Cdd:cd21340  35 KITKIEN--LEFLTNLTHLYLQNNQIEKIEN-LENLVNLKKLYLGGNRISvveglenltnleelhienqrlppgekltfD 111

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19115279 394 CRTFYHISLShLQILVLSRNHLTSLSGLENVPSLEKLDIRDNSITDVVEFRRLVGN-TNFEEAYLSLNPFTKTySSYR 470
Cdd:cd21340 112 PRSLAALSNS-LRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLDLLSSwPSLRELDLTGNPVCKK-PKYR 187
LRR_8 pfam13855
Leucine rich repeat;
340-391 2.29e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.21  E-value: 2.29e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 19115279   340 SSCKLKSIPKNVFLSLQSLVSLDLSGNELTEI-PYALGELPQLCSLNLASNKI 391
Cdd:pfam13855   9 SNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 346-438 2.42e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 50.62  E-value: 2.42e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115279  346 SIPKNVFlSLQSLVSLDLSGNELT-EIPYALGELPQLCSLNLASNKITGCRTFYHISLSHLQILVLSRNHLTS--LSGLE 422
Cdd:PLN00113 275 PIPPSIF-SLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGeiPKNLG 353

                         90
                 ....*....|....*.
gi 19115279  423 NVPSLEKLDIRDNSIT 438
Cdd:PLN00113 354 KHNNLTVLDLSTNNLT 369
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
339-463 3.02e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 90.38  E-value: 3.02e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115279 339 CSSCKLKSIPKNvFLSLQSLVSLDLSGNELTEIPYALGELPQLCSLNLASNKITgcrtfyHIS-----LSHLQILVLSRN 413
Cdd:COG4886 166 LSNNQLTDLPEE-LGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLT------DLPeplanLTNLETLDLSNN 238

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 19115279 414 HLTSLSGLENVPSLEKLDIRDNSITDVVEFRRLvgnTNFEEAYLSLNPFT 463
Cdd:COG4886 239 QLTDLPELGNLTNLEELDLSNNQLTDLPPLANL---TNLKTLDLSNNQLT 285
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
340-463 4.83e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 80.75  E-value: 4.83e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115279 340 SSCKLKSIPKNVFlSLQSLVSLDLSGNELTEIPYALGELPQLCSLNLASNKITGCRTFYhISLSHLQILVLSRNHLTSLS 419
Cdd:COG4886 121 SGNQLTDLPEELA-NLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEEL-GNLTNLKELDLSNNQITDLP 198

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 19115279 420 G-LENVPSLEKLDIRDNSITDVVEFrrLVGNTNFEEAYLSLNPFT 463
Cdd:COG4886 199 EpLGNLTNLEELDLSGNQLTDLPEP--LANLTNLETLDLSNNQLT 241
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
339-439 1.07e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.59  E-value: 1.07e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115279 339 CSSCKLKSIPKnVFLSLQSLVSLDLSGNELTEIPYALGELPQLCSLNLASNKITGCRTFYhiSLSHLQILVLSRNHLTSL 418
Cdd:COG4886 189 LSNNQITDLPE-PLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELG--NLTNLEELDLSNNQLTDL 265

                        90       100
                ....*....|....*....|.
gi 19115279 419 SGLENVPSLEKLDIRDNSITD 439
Cdd:COG4886 266 PPLANLTNLKTLDLSNNQLTD 286
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
352-463 3.87e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.50  E-value: 3.87e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115279 352 FLSLQSLVSLDLSGNELTEIPYALGELPQLCSLNLASNKITgcrtfyHI-----SLSHLQILVLSRNHLTSLS-GLENVP 425
Cdd:COG4886 109 LSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLT------DLpeplgNLTNLKSLDLSNNQLTDLPeELGNLT 182

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 19115279 426 SLEKLDIRDNSITDV-VEFRRLvgnTNFEEAYLSLNPFT 463
Cdd:COG4886 183 NLKELDLSNNQITDLpEPLGNL---TNLEELDLSGNQLT 218
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 343-470 1.56e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 64.42  E-value: 1.56e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115279 343 KLKSIPKnvFLSLQSLVSLDLSGNELTEIPYaLGELPQLCSLNLASNKIT-----------------------------G 393
Cdd:cd21340  35 KITKIEN--LEFLTNLTHLYLQNNQIEKIEN-LENLVNLKKLYLGGNRISvveglenltnleelhienqrlppgekltfD 111

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19115279 394 CRTFYHISLShLQILVLSRNHLTSLSGLENVPSLEKLDIRDNSITDVVEFRRLVGN-TNFEEAYLSLNPFTKTySSYR 470
Cdd:cd21340 112 PRSLAALSNS-LRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLDLLSSwPSLRELDLTGNPVCKK-PKYR 187
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
338-475 3.45e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.01  E-value: 3.45e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115279 338 RCSSCKLKSIPKnvFLSLQSLVSLDLSGNELTEIPyALGELPQLCSLNLASNKITGcrtfyhISLSHLQILVLSRNHLTS 417
Cdd:COG4886 234 DLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLP-PLANLTNLKTLDLSNNQLTD------LKLKELELLLGLNSLLLL 304

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 19115279 418 LSGLENVPSLEKLDIRDNSITDVVEFRRLVGNTNFEEAYLSLNPFTKTYSSYRITIFN 475
Cdd:COG4886 305 LLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLL 362
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 355-442 1.12e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.78  E-value: 1.12e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115279 355 LQSLVSLDLSGNELTEIPyALGELPQLCSLNLASNKITGCRTFYhiSLSHLQILVLSRNHLTSLSGLENVPSLEKLDIRD 434
Cdd:cd21340   1 LKRITHLYLNDKNITKID-NLSLCKNLKVLYLYDNKITKIENLE--FLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGG 77


                ....*...
gi 19115279 435 NSITdVVE 442
Cdd:cd21340  78 NRIS-VVE 84
LRR_8 pfam13855
Leucine rich repeat;
340-391 2.29e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.21  E-value: 2.29e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 19115279   340 SSCKLKSIPKNVFLSLQSLVSLDLSGNELTEI-PYALGELPQLCSLNLASNKI 391
Cdd:pfam13855   9 SNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 346-438 2.42e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 50.62  E-value: 2.42e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115279  346 SIPKNVFlSLQSLVSLDLSGNELT-EIPYALGELPQLCSLNLASNKITGCRTFYHISLSHLQILVLSRNHLTS--LSGLE 422
Cdd:PLN00113 275 PIPPSIF-SLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGeiPKNLG 353

                         90
                 ....*....|....*.
gi 19115279  423 NVPSLEKLDIRDNSIT 438
Cdd:PLN00113 354 KHNNLTVLDLSTNNLT 369
LRR_8 pfam13855
Leucine rich repeat;
379-437 4.60e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 4.60e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19115279   379 PQLCSLNLASNKITGCR--TFYHisLSHLQILVLSRNHLTSLSG--LENVPSLEKLDIRDNSI 437
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDdgAFKG--LSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
356-415 8.46e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.67  E-value: 8.46e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19115279   356 QSLVSLDLSGNELTEI-PYALGELPQLCSLNLASNKITG--CRTFYHisLSHLQILVLSRNHL 415
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTlsPGAFSG--LPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 352-435 1.43e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.22  E-value: 1.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115279  352 FLSLQSLVSLDLSGNELT-EIPYALGELPQLCSLNLASNKITGcrtfyHISLSHLQILVLSRNHLT--SLSG-----LEN 423
Cdd:PLN00113 495 LGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSG-----QIPASFSEMPVLSQLDLSqnQLSGeipknLGN 569

                         90
                 ....*....|..
gi 19115279  424 VPSLEKLDIRDN 435
Cdd:PLN00113 570 VESLVQVNISHN 581
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 404-444 3.35e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.38  E-value: 3.35e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 19115279   404 HLQILVLSRNHLTSLSGLENVPSLEKLDIRDNS-ITDVVEFR 444
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNkITDLSDLA 43
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 357-440 9.78e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.57  E-value: 9.78e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115279 357 SLVSLDLSGNELTEIPY--ALGELPQLCSL---NLASNKITG------CRTFYHisLSHLQILVLSRNHLTSLSG----- 420
Cdd:cd00116 138 ALEKLVLGRNRLEGASCeaLAKALRANRDLkelNLANNGIGDagiralAEGLKA--NCNLEVLDLNNNGLTDEGAsalae 215

                        90       100
                ....*....|....*....|.
gi 19115279 421 -LENVPSLEKLDIRDNSITDV 440
Cdd:cd00116 216 tLASLKSLEVLNLGDNNLTDA 236
LRR_8 pfam13855
Leucine rich repeat;
403-440 2.88e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.35  E-value: 2.88e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 19115279   403 SHLQILVLSRNHLTSLSG--LENVPSLEKLDIRDNSITDV 440
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTL 40
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 358-438 3.46e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.60  E-value: 3.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115279  358 LVSLDLSGNELTE-IPYALGELPQLCSLNLASNKITGCRTFYHISLSHLQILVLSRNHLTSL--SGLENVPSLEKLDIRD 434
Cdd:PLN00113 477 LENLDLSRNQFSGaVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQipASFSEMPVLSQLDLSQ 556


                 ....
gi 19115279  435 NSIT 438
Cdd:PLN00113 557 NQLS 560
LRR_9 pfam14580
Leucine-rich repeat;
347-447 4.31e-03

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 38.59  E-value: 4.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115279   347 IP--KNVFLSLQSLVSLDLSGNELTEIPyALGELPQLCSLNLASNKITGCRTFYHISLSHLQILVLSRNHLTSLSGLENV 424
Cdd:pfam14580  31 IPiiENLGATLDQFDTIDFSDNEIRKLD-GFPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLQELGDLDPL 109

                          90       100
                  ....*....|....*....|....*.
gi 19115279   425 PSLEKLD---IRDNSITDVVEFRRLV 447
Cdd:pfam14580 110 ASLKKLTflsLLRNPVTNKPHYRLYV 135
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 356-463 5.38e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.26  E-value: 5.38e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115279 356 QSLVSLDLSGNELTEIPYALGELPQ-------LCSLNLASNKIT--GCRTFYHISLSH-LQILVLSRNHLTSLSG----- 420
Cdd:cd00116  51 PSLKELCLSLNETGRIPRGLQSLLQgltkgcgLQELDLSDNALGpdGCGVLESLLRSSsLQELKLNNNGLGDRGLrllak 130

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 19115279 421 --LENVPSLEKLDIRDNSITDVVEFR---RLVGNTNFEEAYLSLNPFT 463
Cdd:cd00116 131 glKDLPPALEKLVLGRNRLEGASCEAlakALRANRDLKELNLANNGIG 178
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 355-463 6.63e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.83  E-value: 6.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115279  355 LQSLVSLDLSGNELT-EIPYALGELPQLCSLNLASNKITGCRTFYHISLSHLQILVLSRNHLT-----SLSGLENVPSle 428
Cdd:PLN00113 211 MKSLKWIYLGYNNLSgEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgpippSIFSLQKLIS-- 288

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 19115279  429 kLDIRDNSITDvvEFRRLVGN-TNFEEAYLSLNPFT 463
Cdd:PLN00113 289 -LDLSDNSLSG--EIPELVIQlQNLEILHLFSNNFT 321
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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