|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02437 |
PLN02437 |
ribonucleoside--diphosphate reductase large subunit |
1-811 |
0e+00 |
|
ribonucleoside--diphosphate reductase large subunit
Pssm-ID: 178056 [Multi-domain] Cd Length: 813 Bit Score: 1493.47 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 1 MFVYKRDGRQEKVAFDKITARVSRLCYGLDSDHVDPVEITQKVISGVYPGVTTIELDNLAAETAATMTTKHPDYAILAAR 80
Cdd:PLN02437 1 MYVVKRDGRQETVHFDKITARLKKLSYGLSQDHCDPVLVAQKVCAGVYKGVTTSQLDELAAETAAAMTTNHPDYAILAAR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 81 IAVSNLHKQTEKVFSTVVQQLHDYVNPKTDKPAPMISDKIYDIVMKHKDELDSAIIYDRDFTYNFFGFKTLERSYLLRID 160
Cdd:PLN02437 81 IAVSNLHKNTKKSFSETVKDMYNHVNERSGLKAPLIADDVYDIIMKNAARLDSEIIYDRDFDYDYFGFKTLERSYLLKVN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 161 GKVAERPQHMIMRVAVGIHGEDIEAAIETYNLMSQRYFTHASPTLFNAGTPRPQLSSCFLVTMKDDSIEGIYDTLKMCAM 240
Cdd:PLN02437 161 GKVVERPQHMLMRVSVGIHKDDIESAIKTYHLMSQRWFTHASPTLFNAGTPRPQLSSCFLICMKDDSIEGIYDTLKECAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 241 ISKTAGGIGINIHNIRATGSYIAGTNGTSNGIVPMIRVYNNTARYVDQGGNKRPGAFAAYLEPWHADVMDFLELRKTHGN 320
Cdd:PLN02437 241 ISKSAGGIGLSVHNIRATGSYIRGTNGTSNGIVPMLRVFNDTARYVDQGGGKRKGAFAIYLEPWHADIFEFLDLRKNHGK 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 321 EDFRAREMFYALWIPDLFMQRVERNEQWTFFCPNEAPGLADVWGDEFVALYEKYEKENRGRRSLPAQKVWYAILQSQVET 400
Cdd:PLN02437 321 EEHRARDLFYALWIPDLFMERVQSNGDWSLFCPNEAPGLADCWGEEFERLYTKYEREGKAKKVVQAQQLWFAILESQIET 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 401 GNPFMLYKDSCNRKSNQKNVGTIRCSNLCTEIVEYSSPDEVAVCNLASVALPTFI--------------------KDGKY 460
Cdd:PLN02437 401 GTPYMLFKDSCNRKSNQQNLGTIKSSNLCTEIIEYTSPTETAVCNLASIALPRFVrekgvpleshpsklvgslgsKNRYF 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 461 NFQKLHDVVKVVTRNLNKIIDVNYYPVPEARRSNMRHRPVGLGVQGLADAFFALRLPFESAGAKKLNIQIFETIYHAALE 540
Cdd:PLN02437 481 DFEKLAEVTAVVTRNLNKIIDVNYYPVETARRSNMRHRPIGIGVQGLADAFILLGMPFDSPEAQQLNKDIFETIYYHALK 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 541 ASCEIAQVEGTYESYEGSPASQGILQYDMWNVNPTDLWDWAELKEKIAKHGIRNSLLVAPMPTASTSQILGFNECFEPYT 620
Cdd:PLN02437 561 ASSELAAREGPYETYAGSPVSKGILQPDMWGVTPSGRWDWAALREMISKNGVRNSLLVAPMPTASTSQILGNNECFEPYT 640
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 621 SNMYQRRVLSGEFQIVNPWLLKDLVERDLWNEDMKNKLVMLDGSIQAIPEIPQDLKDLYKTVWEISQKTVIDYAADRGPF 700
Cdd:PLN02437 641 SNIYSRRVLSGEFVVVNKHLLHDLTEMGLWTPTLKNKIIAENGSVQKIPEIPDDLKAIYKTVWEIKQRTLVDMAADRGCY 720
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 701 IDQSQSLNIHLKDPSYGKITSMHFYGWKKGLKTGMYYLRTMAASAAIKFTVDPVALrarneesneenkkpvikNGKAEIS 780
Cdd:PLN02437 721 IDQSQSLNIHMDQPNFGKLTSLHFYAWSKGLKTGMYYLRSRAAADAIKFTVDTASL-----------------KPSATGV 783
|
810 820 830
....*....|....*....|....*....|.
gi 19115403 781 AEPTKEEIDIYNEKVlACSIKNPEACEMCSA 811
Cdd:PLN02437 784 AAPEEEDVETKMAQM-VCSLDNREECLACGS 813
|
|
| NrdA |
COG0209 |
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide ... |
85-752 |
0e+00 |
|
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide reductase alpha subunit is part of the Pathway/BioSystem: Pyrimidine salvage
Pssm-ID: 439979 [Multi-domain] Cd Length: 665 Bit Score: 850.24 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 85 NLHKQTEKVFSTVVQQLHDYVNPKTDKpapmisdkiyDIVMKHKDELDSAIIYDRDFTYNFFGFKTLERSYLLR-IDGKV 163
Cdd:COG0209 1 QLRKEALGQYKSFSEKIKYVEEGLYDE----------RLLEEDLEELAAAIDPERDRFFSYNALKTLYDRYLLKdEDGKP 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 164 AERPQHMIMRVAVGIH-----GEDIEAAIETYNLMSQRYFTHASPTLFNAGTPRPQLSSCFLVTMkDDSIEGIYDTLKMC 238
Cdd:COG0209 71 LETPQDLFMRVAMGLAaaekpEDREEWAKEFYDLLSSLRFLPATPTLFNAGTPRGQLSSCFVLPV-EDSLESIFDALKDA 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 239 AMISKTAGGIGINIHNIRATGSYIAGTNGTSNGIVPMIRVYNNTARYVDQGGnKRPGAFAAYLEPWHADVMDFLELRKTH 318
Cdd:COG0209 150 ALLSKSGGGVGFNFSRLRPKGSPIKGTGGVSSGPVPFMKVFDDAAVAVNQGG-KRRGANMVYLRVWHPDIEEFLDLKKNN 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 319 GNEDFRAREMFYALWIPDLFMQRVERNEQWTFFCPNEAPGLADVWGDEFVALYEKYEKENRGRRSLPAQKVWYAILQSQV 398
Cdd:COG0209 229 GDERRRLHNFNISVWIPDLFMEAVEEDEDWTLFSPREVPDLYGLYGEEFEEAYEEYEADGRVYKTIKARELWRKILESAW 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 399 ETGNPFMLYKDSCNRKSNQKNVGTIRCSNLCTEIVEYSSPDEVAVCNLASVALPTFIKDGKYNFQKLHDVVKVVTRNLNK 478
Cdd:COG0209 309 ETGEPGILFKDTINRRNPLPHLGVIHSSNLCGEIPLLPYESEDASCNLGSINLAKFVKDGEFDWEKLEETVRTAVRFLDN 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 479 IIDVNYYPVPEARRSNMRHRPVGLGVQGLADAFFALRLPFESAGAKKLNIQIFETIYHAALEASCEIAQVEGTYESYEGS 558
Cdd:COG0209 389 VIDINDYPVPEIEKANRRHRPIGLGVMGLADALAKLGIPYDSEEARELADEIMEFINYYAYKASAELAKERGAFPAFEGS 468
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 559 PASQGILQYDMW--NVNPTDLWDWAELKEKIAKHGIRNSLLVAPMPTASTSQILGFNECFEPYTSNMYQRRVLS-GEFQI 635
Cdd:COG0209 469 KYAKGILPFDKYldDLLIPTTLDWDALREDIKKHGLRNSTLTAIAPTGTISLIAGTTSGIEPIFSLVYVRKVLDgGEFTV 548
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 636 VNPWLLKDLVERDLWNEDMKNKLvMLDGSIQAIPEIPQDLKDLYKTVWEISQKTVIDYAADRGPFIDQSQSLNIHL-KDP 714
Cdd:COG0209 549 VNPYLVRALKELGLWDEELVEKI-KEDGSVQDIDELPEELKELYVTAYEIDPEWHIDMQAARQKHVDQAISKTLNLpNDA 627
|
650 660 670
....*....|....*....|....*....|....*...
gi 19115403 715 SYGKITSMHFYGWKKGLKTgMYYLRTMAASAAIKFTVD 752
Cdd:COG0209 628 TVEDLAELYLLAWKLGLKG-IYYYRDGSRTGQVLSTGK 664
|
|
| RNR_I |
cd01679 |
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive ... |
167-740 |
0e+00 |
|
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and many viruses, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophages, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class I RNR is oxygen-dependent and can be subdivided into classes Ia (eukaryotes, prokaryotes, viruses and phages) and Ib (which is found in prokaryotes only). It is a tetrameric enzyme of two alpha and two beta subunits; this model covers the major part of the alpha or large subunit, called R1 in class Ia and R1E in class Ib.
Pssm-ID: 153088 [Multi-domain] Cd Length: 460 Bit Score: 762.85 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 167 PQHMIMRVAVGIHGEDIEAAIETYNLMSQRYFTHASPTLFNAGTPRPQLSSCFLVTMkDDSIEGIYDTLKMCAMISKTAG 246
Cdd:cd01679 1 PQDRLMRVALGLASGDLEWAKEFYDLLSKQRFTPATPTLFNAGTPRGQLSSCFLLTV-DDSLESIYDTIKECAQLSKIGG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 247 GIGINIHNIRATGSYIAGTNGTSNGIVPMIRVYNNTARYVDQGGnKRPGAFAAYLEPWHADVMDFLELRKTHGNEDFRAR 326
Cdd:cd01679 80 GIGLNLSNIRATGSPIRGTNGASNGVIPFLKLLNDTARYVDQGG-QRKGAGAVYLEIWHPDIEEFLDLKKNNGDERRRAR 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 327 EMFYALWIPDLFMQRVERneqwtffcpneapgladvwgdefvalyekyekenrgrrslpaqKVWYAILQSQVETGNPFML 406
Cdd:cd01679 159 DLFYGVWIPDLFMERVER-------------------------------------------DLWRKILESQFETGYPYIL 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 407 YKDSCNRKSNQKNVGTIRCSNLCTEIVEYSSP-----DEVAVCNLASVALPTFIKdgkynFQKLHDVVKVVTRNLNKIID 481
Cdd:cd01679 196 FKDTCNRKNPQKHLGTIKSSNLCTEILQPTSPsedepGEDAVCNLASINLGNFVT-----FEKLEEVVKLAVRALDNVID 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 482 VNYYPVPEARRSNMRHRPVGLGVQGLADAFFALRLPFESAGAKKLNIQIFETIYHAALEASCEIAQVEGtyesyegspas 561
Cdd:cd01679 271 LNYYPVPEAKRSNMRHRAIGLGVMGLHDYLALLRIPYESEEALDLNDRIFETINYYALKASCELAKERG----------- 339
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 562 qgilqydmwnvnptdlwdwaelkekiakhGIRNSLLVAPMPTASTSQILGFNECFEPYTSNMYQRRVLSGEFQIVNPWLL 641
Cdd:cd01679 340 -----------------------------GLRNSLLLAIAPTASISQILGATPSIEPITSNIYVRRVLSGEFPVVNPHLE 390
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 642 KDLVERdlwnedmknklvmldgsiqaipeipqdlkDLYKTVWEISQKTVIDYAADRGPFIDQSQSLNIHLKDP-SYGKIT 720
Cdd:cd01679 391 KDLWEY-----------------------------GLYKTAYEIDQRWLIDLAADRQKHIDQGQSLNLFLTPPaTTRDLN 441
|
570 580
....*....|....*....|
gi 19115403 721 SMHFYGWKKGLKTGmYYLRT 740
Cdd:cd01679 442 SLYFYAWKKGLKTL-YYLRT 460
|
|
| Ribonuc_red_lgC |
pfam02867 |
Ribonucleotide reductase, barrel domain; |
216-737 |
0e+00 |
|
Ribonucleotide reductase, barrel domain;
Pssm-ID: 460729 [Multi-domain] Cd Length: 487 Bit Score: 743.64 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 216 SSCFLVTMkDDSIEGIYDTLKMCAMISKTAGGIGINIHNIRATGSYIAGTNGTSNGIVPMIRVYNNTARYVDQGGnKRPG 295
Cdd:pfam02867 1 SSCFLLSV-EDSLDSIYDTLKEAALLSKGGGGIGLNLSKLRAKGSPIRGTGGASSGVVPFLKLFDDSARYVNQGG-KRRG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 296 AFAAYLEPWHADVMDFLELRKTHGNEDFRAREMFYALWIPDLFMQRVERNEQWTFFCPNEAPGLADVWGDEFVAL-YEKY 374
Cdd:pfam02867 79 AAAVYLEVWHPDIEEFLDLKKNNGDEEVRARNLNLGVWVPDLFMERVEADEDWTLFSPREAPDLEDLYGEEFEKEyYERE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 375 EKENRGRRSLPAQKVWYAILQSQVETGNPFMLYKDSCNRKSNQKNVGTIRCSNLCTEIVEYSSPDEVAVCNLASVALPTF 454
Cdd:pfam02867 159 ENEGIRKKTVKARELWFKIAKSQIETGYPYILFKDAVNRKNPQKHLGTIKSSNLCTEIVQPTSPSEIAVCNLASINLAKF 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 455 IK-DGKYNFQKLHDVVKVVTRNLNKIIDVNYYPVPEARRSNMRHRPVGLGVQGLADAFFALRLPFESAGAKKLNIQIFET 533
Cdd:pfam02867 239 VEfGGTFDFEKLREVVKLAVRALDNVIDINDYPVPEARRSNKRHRPIGLGVMGLADALAKLGIPYDSEEARDLNDKIFET 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 534 IYHAALEASCEIAQVEGTYESYEGSPASQGILQYDMWNVNPTD------LWDWAELKEKIAKHGIRNSLLVAPMPTASTS 607
Cdd:pfam02867 319 MYYYALKASSELAKEKGPFPGFEGSKYSKGILQFDKYVKTDFApkasktREDWEELREDIKKYGLRNSQLTAIAPTGSIS 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 608 QILGFNECFEPYTSNMYQRRVLSgefqivnpwllkdlverdlwnedmknklvmldgsiqaipeipQDLKDLYKTVWEISQ 687
Cdd:pfam02867 399 QIAGATESIEPIFSNVYSRKVLS------------------------------------------EETKEYYKTAYDIDQ 436
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|.
gi 19115403 688 KTVIDYAADRGPFIDQSQSLNIHLK-DPSYGKITSMHFYGWKKGLKTGMYY 737
Cdd:pfam02867 437 KAHIDMAAARQPFVDQSISKTLFLPnDATTSDLKSLYLYAWKLGLKTIYYY 487
|
|
| NrdE_NrdA |
TIGR02506 |
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) ... |
145-740 |
0e+00 |
|
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) chain of the class I ribonucleotide reductase (RNR). RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. Class I RNR's generate the required radical (on tyrosine) via a "non-heme" iron cofactor which resides in the beta (small) subunit. The alpha subunit contains the catalytic and allosteric regulatory sites. The mechanism of this enzyme requires molecular oxygen. E. Coli contains two versions of this enzyme which are regulated independently (NrdAB and NrdEF, where NrdA and NrdE are the large chains). Most organisms contain only one, but the application of the gene symbols NrdA and NrdE are somewhat arbitrary. This model identifies RNR's in diverse clades of bacteria, eukaryotes as well as numerous DNA viruses and phage. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274170 [Multi-domain] Cd Length: 617 Bit Score: 731.49 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 145 FFGFKTLERSYLLRI--DGKVAERPQHMIMRVAVGIHG-----EDIEAAIETYNLMSQRYFTHASPTLFNAGTPRPQLSS 217
Cdd:TIGR02506 1 YMGLKELYNRYLLRNaaTGAIYESPQEAYMRVAMGLASlepkdTRLADAIRFYDLLSRLKISPATPTLFNAGTPRGQLSS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 218 CFLVTMKDDSIEGIYDTLKMCAMISKTAGGIGINIHNIRATGSYIAGTNGTSNGIVPMIRVYNNTARYVDQGGnKRPGAF 297
Cdd:TIGR02506 81 CFLLDVTDDTLESIYKAIDDVAQLSKHGGGIGLNLTKLRAIGSPIRGTNNASKGIIPFLKLLDSSVEAVNQGG-KRPGAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 298 AAYLEPWHADVMDFLELRKTHGNEDFRAREMFYALWIPDLFMQRVERNEQWTFFCPNEAPGLADVWGDEFVALYEKYEKE 377
Cdd:TIGR02506 160 AVYLEVWHPDIEEFLDLKKNNGDERRRCDNLFYGLWIPDLFMKRVEEDKDWYLFSPYDVPGLYGLYGEEFEEEYERLEKD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 378 NRGR---RSLPAQKVWYAILQSQVETGNPFMLYKDSCNRkSNQKNVG--TIRCSNLCTEIVEYSSPD---EVAVCNLASV 449
Cdd:TIGR02506 240 VEARkkiRKVSARDLMKDILRTRVETGRPYILFKDAVNK-HNPFKTGggAIKMSNLCTEITQPTDDShkgETAVCNLASV 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 450 ALPTFIKDGKYNFQKLHDVVKVVTRNLNKIIDVNYYPVPEARRSNMRHRPVGLGVQGLADAFFALRLPFESAGAKKLNIQ 529
Cdd:TIGR02506 319 NLANFVMEDKFDFSELEDAVRIAVRFLDNVIDLQNYPTAPAAKSNQRRRSIGIGVMGLHDVLAKLGLPYDSEEARDLNDR 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 530 IFETIYHAALEASCEIAQVEGTYESYEGSPASQGILQYDMWNVNPTDLW-------DWAELKEKIAKHGIRNSLLVAPMP 602
Cdd:TIGR02506 399 IFEAIYYYAIKASAELAKEKGPFPGFSGSKYAKGWLHPDTWEKTIDPKTsmapteeDWEALRERIKEYGLRNSQLTALMP 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 603 TASTSQILGFNECFEPYTSNMYQRRVLSGEFQIVNPWLLKDLVERDLWNEDMKNKLVMLDGSIQAIPEIPQDLKDLYKTV 682
Cdd:TIGR02506 479 TASSSQLTGVTESIEPVFSNIFTKKTLSGEFLIPNKYLMKELEELGLWDADRRGDIVENVGSPQPIAAIPETLKYKYKTA 558
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*....
gi 19115403 683 WEISQKTVIDYAADRGPFIDQSQSLNIHLKD-PSYGKITSMHFYGWKKGLKTgMYYLRT 740
Cdd:TIGR02506 559 YELDQEALIDMAADRQKFVDQSISLNLFLTEeVTAKDLLKLLLLAWKKGLKT-MYYCRS 616
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02437 |
PLN02437 |
ribonucleoside--diphosphate reductase large subunit |
1-811 |
0e+00 |
|
ribonucleoside--diphosphate reductase large subunit
Pssm-ID: 178056 [Multi-domain] Cd Length: 813 Bit Score: 1493.47 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 1 MFVYKRDGRQEKVAFDKITARVSRLCYGLDSDHVDPVEITQKVISGVYPGVTTIELDNLAAETAATMTTKHPDYAILAAR 80
Cdd:PLN02437 1 MYVVKRDGRQETVHFDKITARLKKLSYGLSQDHCDPVLVAQKVCAGVYKGVTTSQLDELAAETAAAMTTNHPDYAILAAR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 81 IAVSNLHKQTEKVFSTVVQQLHDYVNPKTDKPAPMISDKIYDIVMKHKDELDSAIIYDRDFTYNFFGFKTLERSYLLRID 160
Cdd:PLN02437 81 IAVSNLHKNTKKSFSETVKDMYNHVNERSGLKAPLIADDVYDIIMKNAARLDSEIIYDRDFDYDYFGFKTLERSYLLKVN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 161 GKVAERPQHMIMRVAVGIHGEDIEAAIETYNLMSQRYFTHASPTLFNAGTPRPQLSSCFLVTMKDDSIEGIYDTLKMCAM 240
Cdd:PLN02437 161 GKVVERPQHMLMRVSVGIHKDDIESAIKTYHLMSQRWFTHASPTLFNAGTPRPQLSSCFLICMKDDSIEGIYDTLKECAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 241 ISKTAGGIGINIHNIRATGSYIAGTNGTSNGIVPMIRVYNNTARYVDQGGNKRPGAFAAYLEPWHADVMDFLELRKTHGN 320
Cdd:PLN02437 241 ISKSAGGIGLSVHNIRATGSYIRGTNGTSNGIVPMLRVFNDTARYVDQGGGKRKGAFAIYLEPWHADIFEFLDLRKNHGK 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 321 EDFRAREMFYALWIPDLFMQRVERNEQWTFFCPNEAPGLADVWGDEFVALYEKYEKENRGRRSLPAQKVWYAILQSQVET 400
Cdd:PLN02437 321 EEHRARDLFYALWIPDLFMERVQSNGDWSLFCPNEAPGLADCWGEEFERLYTKYEREGKAKKVVQAQQLWFAILESQIET 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 401 GNPFMLYKDSCNRKSNQKNVGTIRCSNLCTEIVEYSSPDEVAVCNLASVALPTFI--------------------KDGKY 460
Cdd:PLN02437 401 GTPYMLFKDSCNRKSNQQNLGTIKSSNLCTEIIEYTSPTETAVCNLASIALPRFVrekgvpleshpsklvgslgsKNRYF 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 461 NFQKLHDVVKVVTRNLNKIIDVNYYPVPEARRSNMRHRPVGLGVQGLADAFFALRLPFESAGAKKLNIQIFETIYHAALE 540
Cdd:PLN02437 481 DFEKLAEVTAVVTRNLNKIIDVNYYPVETARRSNMRHRPIGIGVQGLADAFILLGMPFDSPEAQQLNKDIFETIYYHALK 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 541 ASCEIAQVEGTYESYEGSPASQGILQYDMWNVNPTDLWDWAELKEKIAKHGIRNSLLVAPMPTASTSQILGFNECFEPYT 620
Cdd:PLN02437 561 ASSELAAREGPYETYAGSPVSKGILQPDMWGVTPSGRWDWAALREMISKNGVRNSLLVAPMPTASTSQILGNNECFEPYT 640
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 621 SNMYQRRVLSGEFQIVNPWLLKDLVERDLWNEDMKNKLVMLDGSIQAIPEIPQDLKDLYKTVWEISQKTVIDYAADRGPF 700
Cdd:PLN02437 641 SNIYSRRVLSGEFVVVNKHLLHDLTEMGLWTPTLKNKIIAENGSVQKIPEIPDDLKAIYKTVWEIKQRTLVDMAADRGCY 720
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 701 IDQSQSLNIHLKDPSYGKITSMHFYGWKKGLKTGMYYLRTMAASAAIKFTVDPVALrarneesneenkkpvikNGKAEIS 780
Cdd:PLN02437 721 IDQSQSLNIHMDQPNFGKLTSLHFYAWSKGLKTGMYYLRSRAAADAIKFTVDTASL-----------------KPSATGV 783
|
810 820 830
....*....|....*....|....*....|.
gi 19115403 781 AEPTKEEIDIYNEKVlACSIKNPEACEMCSA 811
Cdd:PLN02437 784 AAPEEEDVETKMAQM-VCSLDNREECLACGS 813
|
|
| NrdA |
COG0209 |
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide ... |
85-752 |
0e+00 |
|
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide reductase alpha subunit is part of the Pathway/BioSystem: Pyrimidine salvage
Pssm-ID: 439979 [Multi-domain] Cd Length: 665 Bit Score: 850.24 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 85 NLHKQTEKVFSTVVQQLHDYVNPKTDKpapmisdkiyDIVMKHKDELDSAIIYDRDFTYNFFGFKTLERSYLLR-IDGKV 163
Cdd:COG0209 1 QLRKEALGQYKSFSEKIKYVEEGLYDE----------RLLEEDLEELAAAIDPERDRFFSYNALKTLYDRYLLKdEDGKP 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 164 AERPQHMIMRVAVGIH-----GEDIEAAIETYNLMSQRYFTHASPTLFNAGTPRPQLSSCFLVTMkDDSIEGIYDTLKMC 238
Cdd:COG0209 71 LETPQDLFMRVAMGLAaaekpEDREEWAKEFYDLLSSLRFLPATPTLFNAGTPRGQLSSCFVLPV-EDSLESIFDALKDA 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 239 AMISKTAGGIGINIHNIRATGSYIAGTNGTSNGIVPMIRVYNNTARYVDQGGnKRPGAFAAYLEPWHADVMDFLELRKTH 318
Cdd:COG0209 150 ALLSKSGGGVGFNFSRLRPKGSPIKGTGGVSSGPVPFMKVFDDAAVAVNQGG-KRRGANMVYLRVWHPDIEEFLDLKKNN 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 319 GNEDFRAREMFYALWIPDLFMQRVERNEQWTFFCPNEAPGLADVWGDEFVALYEKYEKENRGRRSLPAQKVWYAILQSQV 398
Cdd:COG0209 229 GDERRRLHNFNISVWIPDLFMEAVEEDEDWTLFSPREVPDLYGLYGEEFEEAYEEYEADGRVYKTIKARELWRKILESAW 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 399 ETGNPFMLYKDSCNRKSNQKNVGTIRCSNLCTEIVEYSSPDEVAVCNLASVALPTFIKDGKYNFQKLHDVVKVVTRNLNK 478
Cdd:COG0209 309 ETGEPGILFKDTINRRNPLPHLGVIHSSNLCGEIPLLPYESEDASCNLGSINLAKFVKDGEFDWEKLEETVRTAVRFLDN 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 479 IIDVNYYPVPEARRSNMRHRPVGLGVQGLADAFFALRLPFESAGAKKLNIQIFETIYHAALEASCEIAQVEGTYESYEGS 558
Cdd:COG0209 389 VIDINDYPVPEIEKANRRHRPIGLGVMGLADALAKLGIPYDSEEARELADEIMEFINYYAYKASAELAKERGAFPAFEGS 468
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 559 PASQGILQYDMW--NVNPTDLWDWAELKEKIAKHGIRNSLLVAPMPTASTSQILGFNECFEPYTSNMYQRRVLS-GEFQI 635
Cdd:COG0209 469 KYAKGILPFDKYldDLLIPTTLDWDALREDIKKHGLRNSTLTAIAPTGTISLIAGTTSGIEPIFSLVYVRKVLDgGEFTV 548
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 636 VNPWLLKDLVERDLWNEDMKNKLvMLDGSIQAIPEIPQDLKDLYKTVWEISQKTVIDYAADRGPFIDQSQSLNIHL-KDP 714
Cdd:COG0209 549 VNPYLVRALKELGLWDEELVEKI-KEDGSVQDIDELPEELKELYVTAYEIDPEWHIDMQAARQKHVDQAISKTLNLpNDA 627
|
650 660 670
....*....|....*....|....*....|....*...
gi 19115403 715 SYGKITSMHFYGWKKGLKTgMYYLRTMAASAAIKFTVD 752
Cdd:COG0209 628 TVEDLAELYLLAWKLGLKG-IYYYRDGSRTGQVLSTGK 664
|
|
| RNR_I |
cd01679 |
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive ... |
167-740 |
0e+00 |
|
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and many viruses, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophages, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class I RNR is oxygen-dependent and can be subdivided into classes Ia (eukaryotes, prokaryotes, viruses and phages) and Ib (which is found in prokaryotes only). It is a tetrameric enzyme of two alpha and two beta subunits; this model covers the major part of the alpha or large subunit, called R1 in class Ia and R1E in class Ib.
Pssm-ID: 153088 [Multi-domain] Cd Length: 460 Bit Score: 762.85 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 167 PQHMIMRVAVGIHGEDIEAAIETYNLMSQRYFTHASPTLFNAGTPRPQLSSCFLVTMkDDSIEGIYDTLKMCAMISKTAG 246
Cdd:cd01679 1 PQDRLMRVALGLASGDLEWAKEFYDLLSKQRFTPATPTLFNAGTPRGQLSSCFLLTV-DDSLESIYDTIKECAQLSKIGG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 247 GIGINIHNIRATGSYIAGTNGTSNGIVPMIRVYNNTARYVDQGGnKRPGAFAAYLEPWHADVMDFLELRKTHGNEDFRAR 326
Cdd:cd01679 80 GIGLNLSNIRATGSPIRGTNGASNGVIPFLKLLNDTARYVDQGG-QRKGAGAVYLEIWHPDIEEFLDLKKNNGDERRRAR 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 327 EMFYALWIPDLFMQRVERneqwtffcpneapgladvwgdefvalyekyekenrgrrslpaqKVWYAILQSQVETGNPFML 406
Cdd:cd01679 159 DLFYGVWIPDLFMERVER-------------------------------------------DLWRKILESQFETGYPYIL 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 407 YKDSCNRKSNQKNVGTIRCSNLCTEIVEYSSP-----DEVAVCNLASVALPTFIKdgkynFQKLHDVVKVVTRNLNKIID 481
Cdd:cd01679 196 FKDTCNRKNPQKHLGTIKSSNLCTEILQPTSPsedepGEDAVCNLASINLGNFVT-----FEKLEEVVKLAVRALDNVID 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 482 VNYYPVPEARRSNMRHRPVGLGVQGLADAFFALRLPFESAGAKKLNIQIFETIYHAALEASCEIAQVEGtyesyegspas 561
Cdd:cd01679 271 LNYYPVPEAKRSNMRHRAIGLGVMGLHDYLALLRIPYESEEALDLNDRIFETINYYALKASCELAKERG----------- 339
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 562 qgilqydmwnvnptdlwdwaelkekiakhGIRNSLLVAPMPTASTSQILGFNECFEPYTSNMYQRRVLSGEFQIVNPWLL 641
Cdd:cd01679 340 -----------------------------GLRNSLLLAIAPTASISQILGATPSIEPITSNIYVRRVLSGEFPVVNPHLE 390
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 642 KDLVERdlwnedmknklvmldgsiqaipeipqdlkDLYKTVWEISQKTVIDYAADRGPFIDQSQSLNIHLKDP-SYGKIT 720
Cdd:cd01679 391 KDLWEY-----------------------------GLYKTAYEIDQRWLIDLAADRQKHIDQGQSLNLFLTPPaTTRDLN 441
|
570 580
....*....|....*....|
gi 19115403 721 SMHFYGWKKGLKTGmYYLRT 740
Cdd:cd01679 442 SLYFYAWKKGLKTL-YYLRT 460
|
|
| Ribonuc_red_lgC |
pfam02867 |
Ribonucleotide reductase, barrel domain; |
216-737 |
0e+00 |
|
Ribonucleotide reductase, barrel domain;
Pssm-ID: 460729 [Multi-domain] Cd Length: 487 Bit Score: 743.64 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 216 SSCFLVTMkDDSIEGIYDTLKMCAMISKTAGGIGINIHNIRATGSYIAGTNGTSNGIVPMIRVYNNTARYVDQGGnKRPG 295
Cdd:pfam02867 1 SSCFLLSV-EDSLDSIYDTLKEAALLSKGGGGIGLNLSKLRAKGSPIRGTGGASSGVVPFLKLFDDSARYVNQGG-KRRG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 296 AFAAYLEPWHADVMDFLELRKTHGNEDFRAREMFYALWIPDLFMQRVERNEQWTFFCPNEAPGLADVWGDEFVAL-YEKY 374
Cdd:pfam02867 79 AAAVYLEVWHPDIEEFLDLKKNNGDEEVRARNLNLGVWVPDLFMERVEADEDWTLFSPREAPDLEDLYGEEFEKEyYERE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 375 EKENRGRRSLPAQKVWYAILQSQVETGNPFMLYKDSCNRKSNQKNVGTIRCSNLCTEIVEYSSPDEVAVCNLASVALPTF 454
Cdd:pfam02867 159 ENEGIRKKTVKARELWFKIAKSQIETGYPYILFKDAVNRKNPQKHLGTIKSSNLCTEIVQPTSPSEIAVCNLASINLAKF 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 455 IK-DGKYNFQKLHDVVKVVTRNLNKIIDVNYYPVPEARRSNMRHRPVGLGVQGLADAFFALRLPFESAGAKKLNIQIFET 533
Cdd:pfam02867 239 VEfGGTFDFEKLREVVKLAVRALDNVIDINDYPVPEARRSNKRHRPIGLGVMGLADALAKLGIPYDSEEARDLNDKIFET 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 534 IYHAALEASCEIAQVEGTYESYEGSPASQGILQYDMWNVNPTD------LWDWAELKEKIAKHGIRNSLLVAPMPTASTS 607
Cdd:pfam02867 319 MYYYALKASSELAKEKGPFPGFEGSKYSKGILQFDKYVKTDFApkasktREDWEELREDIKKYGLRNSQLTAIAPTGSIS 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 608 QILGFNECFEPYTSNMYQRRVLSgefqivnpwllkdlverdlwnedmknklvmldgsiqaipeipQDLKDLYKTVWEISQ 687
Cdd:pfam02867 399 QIAGATESIEPIFSNVYSRKVLS------------------------------------------EETKEYYKTAYDIDQ 436
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|.
gi 19115403 688 KTVIDYAADRGPFIDQSQSLNIHLK-DPSYGKITSMHFYGWKKGLKTGMYY 737
Cdd:pfam02867 437 KAHIDMAAARQPFVDQSISKTLFLPnDATTSDLKSLYLYAWKLGLKTIYYY 487
|
|
| NrdE_NrdA |
TIGR02506 |
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) ... |
145-740 |
0e+00 |
|
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) chain of the class I ribonucleotide reductase (RNR). RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. Class I RNR's generate the required radical (on tyrosine) via a "non-heme" iron cofactor which resides in the beta (small) subunit. The alpha subunit contains the catalytic and allosteric regulatory sites. The mechanism of this enzyme requires molecular oxygen. E. Coli contains two versions of this enzyme which are regulated independently (NrdAB and NrdEF, where NrdA and NrdE are the large chains). Most organisms contain only one, but the application of the gene symbols NrdA and NrdE are somewhat arbitrary. This model identifies RNR's in diverse clades of bacteria, eukaryotes as well as numerous DNA viruses and phage. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274170 [Multi-domain] Cd Length: 617 Bit Score: 731.49 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 145 FFGFKTLERSYLLRI--DGKVAERPQHMIMRVAVGIHG-----EDIEAAIETYNLMSQRYFTHASPTLFNAGTPRPQLSS 217
Cdd:TIGR02506 1 YMGLKELYNRYLLRNaaTGAIYESPQEAYMRVAMGLASlepkdTRLADAIRFYDLLSRLKISPATPTLFNAGTPRGQLSS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 218 CFLVTMKDDSIEGIYDTLKMCAMISKTAGGIGINIHNIRATGSYIAGTNGTSNGIVPMIRVYNNTARYVDQGGnKRPGAF 297
Cdd:TIGR02506 81 CFLLDVTDDTLESIYKAIDDVAQLSKHGGGIGLNLTKLRAIGSPIRGTNNASKGIIPFLKLLDSSVEAVNQGG-KRPGAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 298 AAYLEPWHADVMDFLELRKTHGNEDFRAREMFYALWIPDLFMQRVERNEQWTFFCPNEAPGLADVWGDEFVALYEKYEKE 377
Cdd:TIGR02506 160 AVYLEVWHPDIEEFLDLKKNNGDERRRCDNLFYGLWIPDLFMKRVEEDKDWYLFSPYDVPGLYGLYGEEFEEEYERLEKD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 378 NRGR---RSLPAQKVWYAILQSQVETGNPFMLYKDSCNRkSNQKNVG--TIRCSNLCTEIVEYSSPD---EVAVCNLASV 449
Cdd:TIGR02506 240 VEARkkiRKVSARDLMKDILRTRVETGRPYILFKDAVNK-HNPFKTGggAIKMSNLCTEITQPTDDShkgETAVCNLASV 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 450 ALPTFIKDGKYNFQKLHDVVKVVTRNLNKIIDVNYYPVPEARRSNMRHRPVGLGVQGLADAFFALRLPFESAGAKKLNIQ 529
Cdd:TIGR02506 319 NLANFVMEDKFDFSELEDAVRIAVRFLDNVIDLQNYPTAPAAKSNQRRRSIGIGVMGLHDVLAKLGLPYDSEEARDLNDR 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 530 IFETIYHAALEASCEIAQVEGTYESYEGSPASQGILQYDMWNVNPTDLW-------DWAELKEKIAKHGIRNSLLVAPMP 602
Cdd:TIGR02506 399 IFEAIYYYAIKASAELAKEKGPFPGFSGSKYAKGWLHPDTWEKTIDPKTsmapteeDWEALRERIKEYGLRNSQLTALMP 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 603 TASTSQILGFNECFEPYTSNMYQRRVLSGEFQIVNPWLLKDLVERDLWNEDMKNKLVMLDGSIQAIPEIPQDLKDLYKTV 682
Cdd:TIGR02506 479 TASSSQLTGVTESIEPVFSNIFTKKTLSGEFLIPNKYLMKELEELGLWDADRRGDIVENVGSPQPIAAIPETLKYKYKTA 558
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*....
gi 19115403 683 WEISQKTVIDYAADRGPFIDQSQSLNIHLKD-PSYGKITSMHFYGWKKGLKTgMYYLRT 740
Cdd:TIGR02506 559 YELDQEALIDMAADRQKFVDQSISLNLFLTEeVTAKDLLKLLLLAWKKGLKT-MYYCRS 616
|
|
| PRK07207 |
PRK07207 |
ribonucleoside-diphosphate reductase subunit alpha; |
7-809 |
0e+00 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 235966 [Multi-domain] Cd Length: 965 Bit Score: 672.06 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 7 DGRQEKVAFDKITARVSRLCYGLDsdHVDPVEITQKVISGVYPGVTTIELDNLAAETAATMTTKHPDYAILAARI----- 81
Cdd:PRK07207 155 DGVRRPLDMARLRALIEEACEGLE--AVDAEPILAETLKNLYDGVPMDEVYKALILAARTLIEKEPNYSYVTARLlldtl 232
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 82 ---AVSNLHKQTEKVFSTVVQQLHDYVNPKTDK--PAPMISDKI--YDIvmkhkDELDSAIIYDRDFTYNFFGFKTLERS 154
Cdd:PRK07207 233 rreALGFLGVPEEVTQAEMATRYAEYFPAFIKKgiEAELLDPKLaqFDL-----ERLGAALDPERDLQFTYLGLQTLYDR 307
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 155 YLLRIDGKVAERPQHMIMRVAVG--IHGEDIEA-AIETYNLMSQRYFTHASPTLFNAGTPRPQLSSCFLVTMKDDsIEGI 231
Cdd:PRK07207 308 YFLHVDGTRIELPQAFFMRVAMGlaLNEIDREArAIEFYNLLSSFDFMSSTPTLFNSGTLRPQLSSCYLTTVPDD-LDGI 386
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 232 YDTLKMCAMISKTAGGIGINIHNIRATGSYIAGTNGTSNGIVPMIRVYNNTARYVDQGGnKRPGAFAAYLEPWHADVMDF 311
Cdd:PRK07207 387 YEAIKDNALLSKFAGGLGNDWTPVRALGSHIKGTNGKSQGVVPFLKVVNDTAVAVNQGG-KRKGAVCAYLETWHLDIEEF 465
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 312 LELRKTHGNEDFRAREMFYALWIPDLFMQRVERNEQWTFFCPNEAPGLADVWGDEFVALYEKYE-KENRGR----RSLPA 386
Cdd:PRK07207 466 LELRKNTGDDRRRTHDMNTANWIPDLFMKRVMEDGEWTLFSPSEVPDLHDLFGKAFEEAYTAYEaKAARGEiklfKKIPA 545
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 387 QKVWYAILQSQVETGNPFMLYKDSCNRKSNQKNVGTIRCSNLCTEIVEYSSPDEVAVCNLASVALPTFIKDGKY-NFQKL 465
Cdd:PRK07207 546 VDLWRKMLSMLFETGHPWITFKDPCNLRSPQQHVGVVHSSNLCTEITLNTSDDEIAVCNLGSVNLVAHIKDGAKlDHEKL 625
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 466 HDVVKVVTRNLNKIIDVNYYPVPEARRSNMRHRPVGLGVQGLADAFFALRLPFESAGAKKLNIQIFETIYHAALEASCEI 545
Cdd:PRK07207 626 KRTVSTAMRMLDNVIDINYYAVPKARNSNLRHRPVGLGIMGFQDALYLLRIPYASDEAVEFADRSMEAVSYYAIWASTEL 705
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 546 AQVEGTYESYEGSPASQGILQYD-----------MWNVNPTDLWDWAELKEKIAKHGIRNSLLVAPMPTASTSQILGFNE 614
Cdd:PRK07207 706 AEERGRYSSYEGSLWSRGILPIDslkllaearggYLEVDRSSTLDWDALRARIKKHGMRNSNCMAIAPTATISNIIGVSQ 785
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 615 CFEPYTSNMYQRRVLSGEFQIVNPWLLKDLVERDLWNEDMKNKLVMLDGSIQAIPEIPQDLKDLYKTVWEISQKTVIDYA 694
Cdd:PRK07207 786 SIEPTYQNLYVKSNLSGEFTVVNPYLVRDLKARGLWDEVMVNDLKYFDGSLQRIDRIPADLKALYATAFEVDPRWLVEAA 865
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 695 ADRGPFIDQSQSLNIHLKDPSYGKITSMHFYGWKKGLKTgMYYLRTMAASAAIKFTVDPVALRARNEESNEenkkpvikN 774
Cdd:PRK07207 866 SRRQKWIDQAQSLNLYMAGASGKKLDETYKLAWLRGLKT-TYYLRTLGATHVEKSTVNTGALNAVSSGGGG--------A 936
|
810 820 830
....*....|....*....|....*....|....*
gi 19115403 775 GKAEISAEPTKEEIdiynekVLACSIKNPEaCEMC 809
Cdd:PRK07207 937 GGAAAAAAAPPAAD------PKACSIDDPD-CEAC 964
|
|
| PRK12365 |
PRK12365 |
ribonucleoside-diphosphate reductase subunit alpha; |
3-809 |
0e+00 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 171440 [Multi-domain] Cd Length: 1046 Bit Score: 566.50 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 3 VYKRDGRQEKVAFDKITARVSRLCYGLdSDHVDPVEITQKVISGVYPGVTTIELDNLAAETAATMTTKHPDYAILAARIA 82
Cdd:PRK12365 238 VLSKDGSTYTMTKSQLLAHFAWACSRF-PETTDAALLADMAFANFYSGIKESEVVLACIMAARANIEKEPDYAFVAAELL 316
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 83 VSNLHKQT-------EKVFSTVVQQLHDYV-NPKTDKPAPMISDkiYDIvmkhkDELDSAIIYDRDFTYNFFGFKTLERS 154
Cdd:PRK12365 317 LDVVYKEAlgkskydEDLEEAHKDHFKRYIlEGDTYRLNPELKH--YDL-----DALAEALDLSRDLQFSYMGVQNLYDR 389
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 155 YLLRIDGKVAERPQHMIMRVAVGI---HGEDIEA-AIETYNLMSQRYFTHASPTLFNAGTPRPQLSSCFLVTMKDDsIEG 230
Cdd:PRK12365 390 YFNHHEGRRLETPQIFWMRVSMGLalnEGQDKTSwAITFYNLLSTFRYTPATPTLFNSGMRHSQLSSCYLSTVQDD-LVH 468
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 231 IYDTLKMCAMISKTAGGIGINIHNIRATGSYIAGTNGTSNGIVPMIRVYNNTARYVDQGGnKRPGAFAAYLEPWHADVMD 310
Cdd:PRK12365 469 IYKVISDNAMLSKWAGGIGNDWTAVRATGALIKGTNGKSQGVIPFIKVANDTAVAVNQGG-KRKGAVCVYLEVWHLDYED 547
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 311 FLELRKTHGNEDFRAREMFYALWIPDLFMQRVERNEQWTFFCPNEAPGLADVWGDEFVALYEKYEK-----ENRGRRSLP 385
Cdd:PRK12365 548 FLELRKNTGDERRRTHDINTASWIPDLFFKRLQQKGTWTLFSPDDVPGLHEAYGEEFEKLYEEYERkvdtgEIRLYKKVE 627
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 386 AQKVWYAILQSQVETGNPFMLYKDSCNRKSNQKNVGTIRCSNLCTEIVEYSSPDEVAVCNLASVALPTFIKDGKYNFQKL 465
Cdd:PRK12365 628 AEDLWRKMLSMLYETGHPWMTFKDPSNIRSAQDHKGVVRCSNLCTEILLNCSETETAVCNLGSINLVEHIVNDGLDEEKL 707
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 466 HDVVKVVTRNLNKIIDVNYYPVPEARRSNMRHRPVGLGVQGLADAFFALRLPFESAGAKKLNIQIFETIYHAALEASCEI 545
Cdd:PRK12365 708 SETISIAIRILDNVIDINFYPTKEAKEANLAHRAIGLGVMGFQDALYKLNISYASQEAVEFADYSSELIAYYAILASSLL 787
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 546 AQVEGTYESYEGSPASQGILQYDMWN------------VNPTDLWDWAELKEKIAKHGIRNSLLVAPMPTASTSQILGFN 613
Cdd:PRK12365 788 AKERGTYSSYKGSKWDRGYLPIDTIEllkeyrgeanllMDTSSRKDWEPVRSLIKEYGMRNSQLMAIAPTATISNIIGVT 867
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 614 ECFEPYTSNMYQRRVLSGEFQIVNPWLLKDLVERDLWNEDMKNKLVMLDGSIQAIPEIPQDLKDLYKTVWEISQKTVIDY 693
Cdd:PRK12365 868 QSIEPTYKHLFVKSNLSGEFTIPNVYLIEKLKKLGIWDADMLDDLKYFDGSLLEIERIPDHLKKIFLTAFEIEPEWIIEC 947
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 694 AADRGPFIDQSQSLNIHLKDPSYGKITSMHFYGWKKGLKTgMYYLRTMAASAAIKFTVDpvalrarneeSNEENKKPV-I 772
Cdd:PRK12365 948 ASRRQKWIDMGQSLNLYLAEPDGKKLSNMYLTAWKKGLKT-TYYLRSSAATSVEKSFVD----------INKRGIQPRwM 1016
|
810 820 830
....*....|....*....|....*....|....*....
gi 19115403 773 KNGKAE--ISAEPTKeeidiyneKVLACSIKnpEACEMC 809
Cdd:PRK12365 1017 KNKSAStsIVVERAK--------KTPVCSLE--EGCESC 1045
|
|
| PRK06539 |
PRK06539 |
ribonucleoside-diphosphate reductase subunit alpha; |
3-751 |
6.95e-147 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 180610 [Multi-domain] Cd Length: 822 Bit Score: 452.07 E-value: 6.95e-147
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 3 VYKRDGRQEKVAFDKITARVSRLCYGLDSDHVDPVEITQKVISGVYPGVTTIELDNLAAETAATMTTKHPDYAILAARIA 82
Cdd:PRK06539 5 VVKRDGSKEPYDANKVNAAIEDAARGLDDAITWVTQLASELEITLFDGITTQQLDEAVIQVALQNVKDDPAFDTVAARLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 83 VSNLHKQTEKVFSTV--VQQLHDYVNPKTdkPAPMISDKIYDIVMKHK---DELDSAIIYDRDFTYNFFGFKTLERSYLL 157
Cdd:PRK06539 85 LKKIYKRVLGDYDSPeeLQDLHANHFRRT--IEKGVAEGLLDSRLGGLfdlERLAAALDPTRDELLKYIGVVTLNNRYGI 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 158 RI-DGKVAERPQHMIMRVAVGI---HGEDIEAAIETYNLMSQRYFTHASPTLFNAGTPRPQLSSCFLVTMKDDsIEGIYD 233
Cdd:PRK06539 163 RArNGDALEVPQYFWMRIAMGLslnEDDPTSSALAFYEKMSKLEYLAAGSTLVNAGTPYPQLSNCFVMEMQDD-IEHIAK 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 234 TLKMCAMISKTAGGIGINIHNIRATGSYIAGTNGTSNGIVPMIRVYNNTARYVDQGGnKRPGAFAAYLEPWHADVMDFLE 313
Cdd:PRK06539 242 TTRDVMWLTKGTGGIGLSVSKLRAQGSPIRSNNTTSTGPIPFMHTIDSVLRAVSRGG-KKFGALCFYMENWHMDFPEFLD 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 314 LRKTHGNEDFRAREMFYALWIPDLFMQRVERNEQWTFFCPNEAPGLADVWGDEFVALYEKY-EKENRGR----RSLPAQK 388
Cdd:PRK06539 321 LRQNSGDPYRRTRTANTAVWISDEFMKRVQNDEDWYLFDPLETPDLNELYGKAFSKRYAQYvEQAEAGRirmfKRITARE 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 389 VWYAILQSQVETGNPFMLYKDSCNRKSNQKNVGTIRCSNLCTEIVEYSSPDEVAVCNLASVALPTFIKDGKYNFQKLHDV 468
Cdd:PRK06539 401 QFRAILMSLQTTSHPWLTWKDTINNRALNNNTGTIHLSNLCTEICLPQDRDNVSVCNLASINLSRHLADGELDWAQLEES 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 469 VKVVTRNLNKIIDVNYYPVPEARRSNMRHRPVGLGVQGLADAFFALRLPFESAGAKKLNIQIFETIYHAALEASCEIAQV 548
Cdd:PRK06539 481 TRLAVRQLDNLIDITASSVKEADFSNQQNRAIGLGVMGFTDMVERLGYSYESEEAYDLIDRIMEHISYAAIDESADLAAE 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 549 EGTYESYEGSPASQGILQYDMW-----------NVNPTDLWDWAELKEKIaKHGIRNSLLVAPMPTASTSQILGFNECFE 617
Cdd:PRK06539 561 RGAYPNFEGSRWSRGMVPVDSIalleadrgvpvDVNRTTRLDWDALRAKV-RGGMRNATLMAIAPTASIGLVAGTTPGLD 639
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 618 PYTSNMYQRRVLSGEFQIVNPWLLKDLVERDLWnEDMKNKLVMLDGSIQAIPEIPQDLKDLYKTVWEISQKTVIDYAADR 697
Cdd:PRK06539 640 PQFSQIFSRSTSSGKFLEVNRNLVADLKELGLW-ETVREEILRSQGDIQEIAAIPDEIKALYRTSFQLSPYAFLEVAARA 718
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|....
gi 19115403 698 GPFIDQSQSLNIHLKDPSYGKITSMHFYGWKKGLKTgMYYLRTMAASAAIKFTV 751
Cdd:PRK06539 719 QKWVDQAISRNMYLESRDIGDMMDIYTAAWEMGVKT-TYYLHMKPRHTAEQSTV 771
|
|
| PRK08447 |
PRK08447 |
ribonucleoside-diphosphate reductase subunit alpha; |
1-752 |
5.36e-140 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 236266 [Multi-domain] Cd Length: 789 Bit Score: 433.00 E-value: 5.36e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 1 MFVYKRDGRQEKVAFDKITARVSRLCYGLDSDHVDPVEITQKVisGVYPGVTTIEL-DNLAAETAATMTTKHPDYAILAA 79
Cdd:PRK08447 2 ITVVKRNGRIEPLDISKIQKYTSDAVEGLEGVSQSELEVDAKI--QFRDGITTEEIqQTLIKTAVDKIDIDRPNWTFVAA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 80 RIAVSNLHKQTEKVfsTVVQQLHDYVN--PKTDKPAPMISDKiYDIvmkhkDELDSAIIYDRDFTYNFFGFKTLERSYLL 157
Cdd:PRK08447 80 RLFLYDLYHKVSGF--TGYNHLKEYFEkgEKEGRILLGLKEK-YDL-----DDLNAYIKPERDLQFNYLGIKTLYDRYLI 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 158 R-IDGKVAERPQHMIMRVAVGIHGEDIEA---AIETYNLMSQRYFTHASPTLFNAGTPRPQLSSCFLVTMKDDsIEGIYD 233
Cdd:PRK08447 152 KdRNNNPIELPQHMFMAIAMFLAQNELDPqkwAKKFYDVISKFEVMLATPTLSNARTTRHQLSSCYIGSTPDN-IEGIFD 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 234 TLKMCAMISKTAGGIGINIHNIRATGSYIAGTNGTSNGIVPMIRVYNNTARYVDQGGNkRPGAFAAYLEPWHADVMDFLE 313
Cdd:PRK08447 231 SYKEMALLSKYGGGIGWDWSKVRAMGSYIDGHKNAAGGIIPFLKITNDIAIAVDQLGT-RKGAIAVYLEPWHMDISDFID 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 314 LRKTHGNEDFRAREMFYALWIPDLFMQRVERNEQWTFFCPNEAPGLADVWGDEFVALYEKYEK-ENRGRRSLPAQKVWYA 392
Cdd:PRK08447 310 LRKNSGEERRRAHDLFPALWINDLFMKRVEEDAMWTLFDPYECKDLTELYGEEFEKRYLEYEKdEKIIKEYINAKELWKK 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 393 ILQSQVETGNPFMLYKDSCNRKSNQKNVGTIRCSNLCTEIVEYSSP-----------------DE--------------- 440
Cdd:PRK08447 390 ILTNYFETGLPFLCFKDNANRANPNAHAGIIRSSNLCTEIFQNTAPnhykikiefedgsieffEEeelvtvdsgitkkak 469
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 441 ------------------------VAVCNLASVALptfikdGKYNFQ-KLHDVVKVVTRNLNKIIDVNYYPVPEARRSNM 495
Cdd:PRK08447 470 kitsldslkgkkiyivekekkdgkTAVCNLASINL------SKINTKeDIERVVPIAIRMLDNVIDLNFYPNRKVKATNL 543
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 496 RHRPVGLGVQGLADAFFALRLPFESAGAKKLNIQIFETIYHAALEASCEIAQVEGTYESYEGSPASQGILQYDMWN---- 571
Cdd:PRK08447 544 KSRAIGLGVMGEAQMLAEHKIAWGSKEHLEKIDEIMEQISYNAIDASSNLALEKGVYPDFEGSNWSKGIFPIDKANeeak 623
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 572 --VNPTDLW----DWAELKEKIAKHGIRNSLLVAPMPTASTSQILGFNECFEPytsnMYQRRvlsgefqivnpwllkdlv 645
Cdd:PRK08447 624 klVERGGLFdsacDWEGLREKVKKDGMRNGYLMAIAPTSSISILVGTTQTIEP----VYKRK------------------ 681
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 646 erdlWNEDmknklvMLDGSIQAI-PEIPQDLKDLYKTVWEISQKTVIDYAADRGPFIDQSQSLNIHLK-DPSYGKITS-M 722
Cdd:PRK08447 682 ----WFEE------NLSGLIPVVvPNLSPETWQYYTPAYDLDQKDLIKAAAVRQKWIDQGQSLNIFLSlDKASGKYLNeI 751
|
810 820 830
....*....|....*....|....*....|
gi 19115403 723 HFYGWKKGLKTgMYYLRTMAASAAIKFTVD 752
Cdd:PRK08447 752 YTLAWKLGLKS-TYYLRSESPESEEVSVAD 780
|
|
| PRK09209 |
PRK09209 |
ribonucleoside-diphosphate reductase subunit alpha; |
128-740 |
7.81e-121 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 181700 [Multi-domain] Cd Length: 761 Bit Score: 382.15 E-value: 7.81e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 128 KDELDSA---IIYDRD--FTYNffGFKTLERSYLLR-IDGKVAERPQHMIMRVAVGI-HGEDIEAAI----ETYNLMSQR 196
Cdd:PRK09209 138 KEELIEAgkmIDPERDklFTYI--GLYLLADRYLATdSDRNVYELPQERWLTIALYLmQNEPRERRMqlvkEAYWALSNL 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 197 YFTHASPTLFNAGTPRPQLSSCFLVTMkDDSIEGIYDTLKMCAMISKTAGGIGINIHNIRATGSYIAGTNGTSNGIVPMI 276
Cdd:PRK09209 216 YMTVATPTLANAGKVGGQLSSCFIDTV-DDSLQGIYDSNTDVARVSKHGGGVGAYLGKVRSRGSDIRGFKGVSSGVIPWI 294
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 277 RVYNNTARYVDQGGnKRPGAFAAYLEPWHADVMDFLELRKTHGNEDFRAREMFYALWIPDLFMQRVERNEQWTFFCPNEA 356
Cdd:PRK09209 295 KQLNNTAVSVDQLG-QRKGAIAVYLDVWHKDIESFLDLRLNNGDERLRAHDVFTGVCIPDLFMEAVERRGDWYLFDPHEV 373
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 357 P-----GLADVWGDE-----FvalYEKYEK----ENRGRRSLPAQKVWYAILQSQVETGNPFMLYKDSCNRKSNQKNVGT 422
Cdd:PRK09209 374 KkvmgwYLEDFYDEKkgdgsF---REKYEEcvadERLSRKTVKAIDIMKRIMVSQLETGNPFMFYRDEVNRMNPNKHEGM 450
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 423 IRCSNLCTEIVEYSSPDEV-------------------AVCNLASVALPTFIKDGkynfqKLHDVVKVVTRNLNKIIDVN 483
Cdd:PRK09209 451 IYSSNLCTEIMQNMSPTVMiqeiisggqivitkqpgdfVVCNLSSINLGRAVTAD-----VLERLIPIQVRMLDNVIDLN 525
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 484 YYPVPEARRSNMRHRPVGLGVQGLaDAFFALR-LPFESAGAKKLNIQIFETIYHAALEASCEIAQVEGTYESYEGSPASQ 562
Cdd:PRK09209 526 QLPVPQATITNQKYRAIGLGTFGW-HHLLALKgIAWESEEAVQYADELYERINYLTIQASMELAKEKGAYPVFKGSDWQT 604
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 563 GilQY-DMWNVNPTdlwDWAELKEKIAKHGIRNSLLVAPMPTASTSQILGFNECFEPYTSNMYQRRVLSGEFQIVNPwll 641
Cdd:PRK09209 605 G--EYfERRGYNSP---QWDELAAQVAENGVRNAYLMAVAPNMSTAQIAGSTASIDPIYSAFYYEEKKDYRRPVTAP--- 676
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 642 kDLVERDLWnedmknklvmldgsiqaipeipqdlkdLY-KTVWEISQKTVIDYAADRGPFIDQSQSLNIHLK-DPSYGKI 719
Cdd:PRK09209 677 -DLSLDTWP---------------------------YYeKGAYKVDQFWSIRQNAARQRHVDQSISFNFYVPsTIRASEL 728
|
650 660
....*....|....*....|.
gi 19115403 720 TSMHFYGWKKGLKTgMYYLRT 740
Cdd:PRK09209 729 LDLHMTAWKEGLKT-TYYVRS 748
|
|
| PRK12364 |
PRK12364 |
ribonucleoside-diphosphate reductase subunit alpha; |
72-742 |
1.67e-120 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 237077 [Multi-domain] Cd Length: 842 Bit Score: 383.33 E-value: 1.67e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 72 PDYAILAARIAVSNLHKQTEKVFSTVvqQLHDYvnpkTDKPAPMISDKIY-DIVMKH--KDELDSA---IIYDRDFTYNF 145
Cdd:PRK12364 165 PDWEFIAARLLMLQFSKKLGKSLEKL--GIHSF----YDKIKYLTEEGLYgSYILEHysREEIEEAagfIDPERDKLFTY 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 146 FGFKTLERSYLLRI-DGKVAERPQHMIMRVAVGI----HGEDIEAAIETYNLMSQRYFTHASPTLFNAGTPRPQLSSCFL 220
Cdd:PRK12364 239 SGLDLLLKRYVIRThSHEPLESPQEMFLGIALHLampeKQDRMGWVKRFYDMLSKLKVTMATPTLSNARKPFHQLSSCFI 318
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 221 VTMKDdSIEGIYDTLKMCAMISKTAGGIGINIHNIRATGSYIAGTNGTSNGIVPMIRVYNNTARYVDQGGnKRPGAFAAY 300
Cdd:PRK12364 319 DTVPD-SLDGIYRSIDNFAQVSKFGGGMGLYFGKVRAVGSNIRGFQGVAGGVIRWIKLANDTAVAVDQLG-MRQGAVAVY 396
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 301 LEPWHADVMDFLELRKTHGNEDFRAREMFYALWIPDLFMQRVER--NEQWTFFCPNE-----APGLADVWGDEFVALYEK 373
Cdd:PRK12364 397 LDVWHKDIPEFLQLRTNNGDDRMKAHDVFPAVCYPDLFWKMVRDdiNQSWYLFCPHEiltvkGYALEDYYGEEWEKRYLD 476
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 374 YEKENR-GRRSLPAQKVWYAILQSQVETGNPFMLYKDSCNRKSNQKNVGTIRCSNLCTEI-------------------- 432
Cdd:PRK12364 477 CVNDARiSKRSIPIKDLVRLILKSAVETGTPFTFNRDTVNRANPNKHKGMIYCSNLCTEIaqnmsaietvsteietedgd 556
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 433 ---VEYSSPDEVAVCNLASVALPTFIKDgkyNFQKLHDVVKVVTRNLNKIIDVNYYPVPEARRSNMRHRPVGLGVQGLAD 509
Cdd:PRK12364 557 tvvVTTTRPGDFVVCNLASLSLGNIDLE---DEEELEEVVRTVVRALDNVIDLNFYPVPYAQITNKRYRSIGLGVSGYHH 633
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 510 AFFALRLPFESAGAKKLNIQIFETIYHAALEASCEIAQVEGTYESYEGSPASQGILqYDMWNVNPTdlwDWAELKEKIAK 589
Cdd:PRK12364 634 ALAKNGIRWESEEHLEFADRVFERINYAAIKASMEIAKEKGAYGYFEGSDWQTGAY-FRKRGYTSE---EWQRLAREVAE 709
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 590 HGIRNSLLVAPMPTASTSQILGFNECFEPytsnmyqrrvlsgefqIVNPWLLkdlverdlwnEDMKNKLVMldgsiQAIP 669
Cdd:PRK12364 710 NGMRNAYLLAVAPTSSTSIIAGTTAGVDP----------------VMKRYFL----------EEKKGALMP-----RVAP 758
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 19115403 670 EIPQDLKDLYKTVWEISQKTVIDYAADRGPFIDQSQSLNIHL-KDPSYGKITSMHFYGWKKGLKTgMYYLRTMA 742
Cdd:PRK12364 759 ELSDKTFWLYKNAHLIDQKWSIRAAGVRQRHIDQAQSVNLYItNEFTMRQVLDLYLLAWEEGVKT-IYYVRSKS 831
|
|
| PRK09102 |
PRK09102 |
ribonucleoside-diphosphate reductase subunit alpha; |
125-767 |
5.43e-118 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 236378 [Multi-domain] Cd Length: 601 Bit Score: 369.67 E-value: 5.43e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 125 MKHKDELDSAIIYD--RDFTYNFFGFKTLERSYLLriDGkvaERPQHMIMRVAVGIHGEDIEAAIETYNLMSQRYFTHAS 202
Cdd:PRK09102 1 EKMQNKLVFQINIDrsRDAWLTEFGKATLRDRYLL--EG---ESYQDLFARIAEAYADIDPEHAQRFYDYMSRGWFMPAT 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 203 PTLFNAGTPRPQLSSCFLVTMkDDSIEGIYDTLKMCAMISKTAGGIGINIHNIRATGSYIaGTNGTSNGIVPMIRVYNNT 282
Cdd:PRK09102 76 PVLSNGGTDRGLPISCFLNYV-EDSLEGIVNTWNENVWLAKRGGGIGSYWGNVRSIGEPI-RNNGKSSGIIPFIKVMDSL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 283 ARYVDQGGNKRpGAFAAYLEPWHADVMDFLELRKTHGNEDFRAREMFYALWIPDLFMQRVERNEQWTFFCPneapgladv 362
Cdd:PRK09102 154 TLAISQGSLRR-GSFAVYLDIEHPEIEEFLDIRKPTGDPNRKALNLHHGVCVTDEFMEAVEDGDEWDLISP--------- 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 363 wgdefvalyekyeKENRGRRSLPAQKVWYAILQSQVETGNPFMLYKDSCNRK--SNQKNVG-TIRCSNLCTEI-----VE 434
Cdd:PRK09102 224 -------------KDKSVIRTVKARDLWAKILETRIETGEPYLLFIDNVNRAlpEVYKDLGlKVKASNLCSEItlptgID 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 435 YSSPDEVAVCNLASVALPTFI--KDGKynfqklhDVVKVVTRNLNKI----IDVNYYPVPEARRSNMRHRPVGLGVQGLA 508
Cdd:PRK09102 291 HLGEDRTAVCCLSSLNLEYYDewKDTD-------AFIEDLMRFLDNVlqdfIDKAPDEMERAKYSAMRERSVGLGVMGFH 363
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 509 DAFFALRLPFESAGAKKLNIQIFETIYHAALEASCEIAQVEGTYESYEGSpasqGILQydmwnvnptdlwdwaelkekia 588
Cdd:PRK09102 364 SYLQSKMIPFESVMAKQWNKKIFKHIREQADKASKELAKEKGECPDAAGY----GVMR---------------------- 417
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 589 khgiRNSLLVAPMPTASTSQILG-FNECFEPYTSNMYQRRVLSGEFQIVNPWLLKDLVERDLWNEDMKNKLVMLDGSIQA 667
Cdd:PRK09102 418 ----RFSTKMAIAPTASISIILGnTSPGIEPIAANYYTHKTLKGSFTVKNKYLEKLLEEKGKDTDEVWSSILTNEGSVQH 493
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 668 IPEIPQDLKDLYKTVWEISQKTVIDYAADRGPFIDQSQSLNIHL-KDPSYGKITSMHFYGWKKGLKTgMYYLRTMAASAA 746
Cdd:PRK09102 494 LDFLSEEEKDVFKTAFEIDQRWIIELAADRQKYIDQAQSLNLFLpANVPKRDLNKLHFEAWKKGVKS-LYYQRSKSVQRA 572
|
650 660
....*....|....*....|.
gi 19115403 747 IKftVDPVALRARNEESNEEN 767
Cdd:PRK09102 573 DK--VSHDVLKKRLVEKSAFN 591
|
|
| PRK07088 |
PRK07088 |
ribonucleoside-diphosphate reductase subunit alpha; |
1-740 |
1.10e-117 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 180831 [Multi-domain] Cd Length: 764 Bit Score: 373.76 E-value: 1.10e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 1 MFVYKRDGRQEKVAFDKITARVSRLCYGLDSDhvDPVEITQKVISGVYPGVTT-----------IELDNLAAETAATMTT 69
Cdd:PRK07088 3 IKIKKRDGQYEPLQVEKTKKMVKLACEGLYGC--DPLELELDSRIQFRDGMTTkeiqksliqtaIEKVIQNSKDNNGNNT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 70 K--HPDYAILAARIAVSNLHKQTEK---VFSTVVQQLHDYVNPKTDKP--APMISDKIYDIVMKhkdELDSAIIYDRDFT 142
Cdd:PRK07088 81 KktNPNWQYVAARLYVFDLYKEARInrhYNSFGYGDYYELVKKLVEEKlyGEYLLQNYSKEEIK---ELEKYIKPERDFL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 143 YNFFGFKTLERSYLLR-IDGKVAERPQHMIMRVAVGI-----HGEDIEAAIETYNLMSQRYFTHASPTLFNAGTPRPQLS 216
Cdd:PRK07088 158 FNYEGLKLLADRYLVKgFNREILELPQERFMGIAMHLaipegKEKRVYYAKKFYDLLSELKATVATPTLSNAGTPFYQLS 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 217 SCFLVTMkDDSIEGIYDTLKMCAMISKTAGGIGINIHNIRATGSYIAGTNGTSNGIVPMIRVYNNTARYVDQGGnKRPGA 296
Cdd:PRK07088 238 SCFISVV-DDNLWSIYDVNQKFAQVSKHGGALGIYTGKIRALNSEIRGFKNASGGVIPWIKLYNDTAIAVDQLG-KRKGG 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 297 FAAYLEPWHADVMDFLELRKTHGNEDFRAREMFYALWIPDLFMQRVERNEQWTFFCPNEAP-----GLADVWGDEFVALY 371
Cdd:PRK07088 316 AAITLDIWHKDIPEFLDLKTNNGDDRRKAHDIFPGVSYPDLFMKRLEKRENWSLFDPHEIKkvkgySLEDYYDEEDRKEF 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 372 EK-----YEKENRGRRSLPAQKVWYAILQSQVETGNPFMLYKDSCNRKSNQKNVGTIRCSNLCTEIVEYSSPDEVA---- 442
Cdd:PRK07088 396 TKkylecEEDTNIPRRTVPVLDIMKKIMKSAVETGTPFIFFRDTVNKANPNKHKGMIYSSNLCHEIAQNMSESELLeeei 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 443 -------------------VCNLASVALptfikdGKYNFQKLHDVVKVVTRNLNKIIDVNYYPVPEARRSNMRHRPVGLG 503
Cdd:PRK07088 476 idengyyevvqkikagdmvTCNLNSIVL------GNVDDEELEEVIPTQIRMLDNVISLNYYPVPEAEITSDKYRAIGLG 549
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 504 VQGLADAFFALRLPFESAGAKKLNIQIFETIYHAALEASCEIAQVEGTYESYEGSPASQGILqYDMWNVNPTDlwdWAEL 583
Cdd:PRK07088 550 TSGYHHMLANNKIRWESDEHIKFADKIYEEIAYYAIKASMELAKEKGSYPAFKGSEWETGKY-FERRGYNSER---WKKL 625
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 584 KEKIAKHGIRNSLLVAPMPTASTSQILGFNECFEPytsnmyqrrvlsgefqivnpwllkdlVERDLWNEDMKnklvmldG 663
Cdd:PRK07088 626 KEEIKKYGMRNGYITAVAPTGSTSNIANTTAGIDP--------------------------VFKRFFMEEKK-------G 672
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 664 SIqaIPEIPQDLKD----LYKTVWEISQKTVIDYAADRGPFIDQSQSLNIHLKdPSYGKITSMHFY--GWKKGLKTgMYY 737
Cdd:PRK07088 673 SF--TPKTAPDLNEenfwYYKEAHTIDQQWSIKACGVRQRHIDQAQSFNLYIT-PEYKAKQILNLYieAWKQGVKT-IYY 748
|
...
gi 19115403 738 LRT 740
Cdd:PRK07088 749 VRN 751
|
|
| NrdJ_Z |
TIGR02504 |
ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; This model represents a ... |
151-732 |
1.60e-94 |
|
ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; This model represents a group of adenosylcobalamin(B12)-dependent ribonucleotide reductases (Class II RNRs) related to the characterized species from Pyrococcus, Thermoplasma, Corynebacterium, and Deinococcus. RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. This model identifies genes in a wide range of deeply branching bacteria. All are structurally related to the class I (non-heme iron dependent) RNRs. In most species this gene is known as NrdJ, while in mycobacteria it is called NrdZ. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274168 [Multi-domain] Cd Length: 575 Bit Score: 306.94 E-value: 1.60e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 151 LERSYLLRI-DGKVAERPQHMIMRVAVGIHGEDIEAAIET--------YNLMSQRYFTHASPTLFN-AGTPRPQLSSCFL 220
Cdd:TIGR02504 2 LAARYLLKDeDGNIIESPEDLFRRVARALAAAEDKYNSPVwkqwyerfYDLMVNLGFIPNSPTLMNaGGTRLGQLSACFV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 221 VTMKDDSiEGIYDTLKMCAMISKTAGGIGINIHNIRATGSYIAGTNGTSNGIVPMIRVYNNTARYVDQGGnKRPGAFAAY 300
Cdd:TIGR02504 82 LPVEDSM-EDIFEALKEAALIFKRGGGVGYNFSTLRPKGDLVSGTGGVASGPVSFMRVFDSAAGVVKQGG-TRRGAQMGI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 301 LEPWHADVMDFLELRKthGNEDFRAREMFYALWipDLFMQRVERNEQWTffcpneapgladvwgdefvaLYEKYEKEnrg 380
Cdd:TIGR02504 160 LDVWHPDIEEFIEAKA--KEGKLQNFNISVGVT--DEFMEAVENDEEYE--------------------LRNPRTGE--- 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 381 RRSLPAQKVWYAILQSQVETGNPFMLYKDSCNRKSNQKNVGTIRCSNLCTEIVEYssPDEVavCNLASVALPTFIKDGK- 459
Cdd:TIGR02504 213 YKEVDARELWDKIVESAWKSAEPGVLFIDTINKWHTCPYGGRINATNPCGEQPLL--PYES--CNLGSINLAKFVKNDFg 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 460 ----YNFQKLHDVVKVVTRNLNKIIDVNYYPVPEARRSNMRHRPVGLGVQGLADAFFALRLPFESAGAKKLNIQIFETIY 535
Cdd:TIGR02504 289 deasFDFERLREVVRLATRFLDNVIDINVFPLPEIAENTKKTRRIGLGIMGLADLLIKLGIPYDSEEARELAEEVMEFIA 368
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 536 HAALEASCEIAQVEGTYESYEGSPASQGilqYDMWNVNPTDLwdWAELKEKIAKHGIRNSLLVAPMPTASTSQILGFNEC 615
Cdd:TIGR02504 369 DAAYRASAELAKERGAFPLYDASKYPMG---RAMGARIPSAL--PAEIREAIRKYGIRNAQLTTIAPTGTISLIAGTSSG 443
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 616 FEPYTSNMYQRRVL-SGEFQIVNPWLLKDLVERDLWNEDmKNKLVMLDGSIQAIPEiPQDLKDLYKTVWEISQKTVIDYA 694
Cdd:TIGR02504 444 IEPVFALVYFRNVTvGGELLEVNPLVELALRELGYYSDE-IVKYVDEKGTVEGAPG-PEELPKVFVTAMDISPEDHVLMQ 521
|
570 580 590
....*....|....*....|....*....|....*....
gi 19115403 695 ADRGPFIDQSQSLNIHL-KDPSYGKITSMHFYGWKKGLK 732
Cdd:TIGR02504 522 AAIQPWVDSSISKTINMpSDATVEDVKAVYLEAWKLGLK 560
|
|
| RNR_II_dimer |
cd02888 |
Class II ribonucleotide reductase, dimeric form; Ribonucleotide reductase (RNR) catalyzes the ... |
188-619 |
1.28e-93 |
|
Class II ribonucleotide reductase, dimeric form; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and bacteriophage, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophage, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class II RNRs are found in bacteria that can live under both aerobic and anaerobic conditions. Many, but not all members of this class are found to be homodimers. Adenosylcobalamin interacts directly with an active site cysteine to form the reactive cysteine radical.
Pssm-ID: 153089 [Multi-domain] Cd Length: 464 Bit Score: 301.08 E-value: 1.28e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 188 ETYNLMSQRYFTHASPTLFNAGT-PRPQLSSCFLVTMKDDSIEGIYDTLKMCAMISKTAGGIGINIHNIRATGSYIAGTN 266
Cdd:cd02888 3 EFFYLLLSQGFIPNSPTLMNAGTgELGQLSACFVLPVEDDSIEGIFDALKEAALIFKRGGGVGYNFSRLRPKGDIVKSTG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 267 GTSNGIVPMIRVYNNTARYVDQGGnKRPGAFAAYLEPWHADVMDFLELRKTHGNEDFraremfyalW--------IPDLF 338
Cdd:cd02888 83 GVASGPVSFMRVFDAATGVIKQGG-TRRGANMGVLDVDHPDIEEFIDAKMKEEKTVV---------LqnfnisvaVTDAF 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 339 MQRVERNEQWTFFCPNEAPGLAdVWgdefvalyekyekenrgrRSLPAQKVWYAILQSQVETGNPFMLYKDSCNRKSNQK 418
Cdd:cd02888 153 MEAVENDEPWELRNPREPDTGK-VY------------------RTVPARELWDKIVEAAWDSADPGVLFIDTINRWNPLP 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 419 NVGTIRCSNLCTEIV--EYSSpdevavCNLASVALPTFIKDG----KYNFQKLHDVVKVVTRNLNKIIDVNYYPVPEARR 492
Cdd:cd02888 214 GLGRINATNPCGEQPllPYES------CNLGSINLSKFVKNPfggaSFDFERLREAVRLAVRFLDNVIDVNRYPLPEIAE 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 493 SNMRHRPVGLGVQGLADAFFALRLPFESAGAKKLNIQIFETIYHAALEASCEIAQVEGTYESYEGSpasqgilQYDMWNV 572
Cdd:cd02888 288 ETKATRRIGLGVMGLADMLIKLGIPYDSEEARELAERIMSFIRDAAYRASAELAKERGPFPLFDAS-------RYLMLKV 360
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 19115403 573 NPTDLWDWAELKEKIAKHGIRNSLLVAPMPTASTSQILGFNECFEPY 619
Cdd:cd02888 361 IVNAKELPDDVLEEIEKYGIRNAHLTTIAPTGTISLIAGTSSGIEPI 407
|
|
| nrdA |
PHA02572 |
ribonucleoside-diphosphate reductase subunit alpha; Provisional |
1-740 |
2.76e-90 |
|
ribonucleoside-diphosphate reductase subunit alpha; Provisional
Pssm-ID: 222883 [Multi-domain] Cd Length: 753 Bit Score: 300.87 E-value: 2.76e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 1 MFVYKRDGRQEKVAFDKITARVSRLCYGLDsdhVDPVEITQKVISGVYPGVTTIELDN-LAAETAATMTTKHPDYAILAA 79
Cdd:PHA02572 4 INVIKSSGVSQPFDLEKIHKVLEWACEGTG---VDPSELEENSKIQLRDGMTTKDIQEiLIKSAADLISVEEPDYQYVAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 80 RIAVSNLHKQtekvfstVVQQLHDyvNPKTDKPAPMISDKIYD--IVMKHKDE----LDSAIIYDRDFTYNFFGFKTLER 153
Cdd:PHA02572 81 RLLMFALRKQ-------VYGQFEP--PSFIDHISKCVNEGKYDpeILSKYSAEeityLESFIDHDRDFEFTYAGAMQLKE 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 154 SYLL--RIDGKVAERPQHMIMRVAVGIHGED-----IEAAIETYNLMSQRYFTHASPTLFNAGTPRPQLSSCFLVTMkDD 226
Cdd:PHA02572 152 KYLVqdRSTGEIYETPQFAYMLIAMALHQDEpkedrLEHVIRFYNAVSTRKISLPTPIMAGVRTPTRQFSSCVVIES-GD 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 227 SIEGIYDTLK-MCAMISKTAGgIGINIHNIRATGSYIAGTNGTSNGIVPMIRVYNNTARYVDQGGnKRPGAFAAYLEPWH 305
Cdd:PHA02572 231 SLDSINKTAMaIVKYISKRAG-IGINAGMIRAEGSKIRGGEVRHTGVIPFWKHFQTAVKSCSQGG-IRGGAATAYYPIWH 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 306 ADVMDFLELRKTHGNEDFRAREMFYALWIPDLFMQRVERNEQWTFFCPNEAPGL------ADVwgDEFVALYEKYEKENR 379
Cdd:PHA02572 309 LEVEDLLVLKNNKGVEENRIRHLDYGVQINDLMYERFIKNDYITLFSPHDVGGElydayfADQ--DRFRELYEALEKDPS 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 380 GRRS-LPAQKVWYAILQSQVETGNPFMLYKDSCNRKSNQKNvgTIRCSNLCTEIV----EYSSPD---EVAVCNLASVAL 451
Cdd:PHA02572 387 VRKKrIKAQELFLLLLKERSETGRIYIMFIDHCNNHSPFKD--PIRQSNLCCEIAlptkPLNHIDgegEIALCTLSAIVL 464
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 452 PTFikdgkYNFQKLHDVVKVVTRNLNKIIDVNYYPVPEARRSNMRhRPVGLGVQGLAdAFFALR-LPFESAGAKKLNiQI 530
Cdd:PHA02572 465 GNF-----EDQDEIEELAEVAVRALDNLLDYQDYPVPAALKAKKR-RSLGVGVTNYA-HYLAKNfASYEDANADLVH-EL 536
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 531 FETIYHAALEASCEIAQVEGTYESYEGSPASQGILQYDMWN------VNPTDLWDWAELKEKIAKHGIRNSLLVAPMPTA 604
Cdd:PHA02572 537 FERLQYYLIKASNKLAKEKGACEYFSDTKYSRGELPIDWYKkkvdelVAPKYNCDWESLREDLKKYGIRNSTLSALMPCE 616
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 605 STSQILGFNECFEPytsnmyQRRVLSgefqivnpwlLKdlverdlwnedmKNKlvmlDGSI-QAIPEIpQDLKDLYKTVW 683
Cdd:PHA02572 617 SSSQVSNSTNGIEP------PRGPVS----------IK------------KSK----EGPFnQVVPNV-ETLKDLYDLLW 663
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19115403 684 EISQKTVIDY---AADRGPFIDQSQSLNIHLkDPSY---GKI-TSMHF----YGWKKGLKTgMYYLRT 740
Cdd:PHA02572 664 DLAKKGNKGYltqVAIMQKFVDQAISANTSY-DPENypnGKVpMSVMLddllYFYYYGGKT-LYYHNT 729
|
|
| PRK08665 |
PRK08665 |
vitamin B12-dependent ribonucleotide reductase; |
151-686 |
1.82e-77 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 236330 [Multi-domain] Cd Length: 752 Bit Score: 266.03 E-value: 1.82e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 151 LERSYLLR-IDGKVAERPQHMIMRVAVGI--------HGEDIEA-AIETYNLMSQRYFTHASPTLFNAGTPRPQLSSCFl 220
Cdd:PRK08665 20 LEKRYLKKdEDGKPIETPEDMFRRVARTIaaaeliydSKADVEAlADRFYDLMTSLEFLPNSPTLMNAGRELGQLSACF- 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 221 VTMKDDSIEGIYDTLKMCAMISKTAGGIGINIHNIRATGSYIAGTNGTSNGIVPMIRVYNNTARYVDQGGNKRpGAFAAY 300
Cdd:PRK08665 99 VLPVGDSIEEIFDAVKHAALIHKSGGGTGFSFSRLRPKNDRVGSTGGVASGPVSFMRVFDAATEAIKQGGTRR-GANMGI 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 301 LEPWHADVMDFLELRKthgnedfRAREM--F-YALWIPDLFMQRVERNEQWTFFCPNEapgladvwgdefvalyekyeKE 377
Cdd:PRK08665 178 LRVDHPDIMEFITCKE-------DNGELtnFnISVAITEAFMEAVEADEEYDLINPRT--------------------GE 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 378 NRGRrsLPAQKVWYAILQSQVETGNPFMLYKDSCNRKSNQKNVGTIRCSNLCTE--IVEYSSpdevavCNLASVALPTFI 455
Cdd:PRK08665 231 VVGR--LNAREVFDLIVEMAWENGEPGIVFIDRINRDNPTPHLGEIESTNPCGEqpLLPYES------CNLGSINLSKMV 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 456 KDGKYNFQKLHDVVKVVTRNLNKIIDVNYYPVPEARRSNMRHRPVGLGVQGLADAFFALRLPFESAGAKKLNIQIFETIY 535
Cdd:PRK08665 303 KNGDVDWEKLREVVHLAVRFLDNVIDANKYPLPQIEEMTKGNRKIGLGVMGWADMLIQLGIPYDSEEAVELAEKVMKFIQ 382
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 536 HAALEASCEIAQVEGTYESYEGSpasqgilqydmwnvnptdLWDwaelKEKIAKhgIRNSLLVAPMPTASTSQILGFNEC 615
Cdd:PRK08665 383 DEAHAASRELAEERGPFPNYEGS------------------IYD----KDGLGP--MRNATVTTIAPTGTISIIAGCSSG 438
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19115403 616 FEPYTSNMYQRRVLSGEFQI-VNPWLLKDLVERDLWNEDMKNKlVMLDGSIQAIPEIPQDLKDLYKTVWEIS 686
Cdd:PRK08665 439 IEPLFALSFTRNVMDGERLVeVNPVFEAAAKEEGFYSEELMEK-IAEKGSIQDIDEVPEDVRRVFVTAHDIS 509
|
|
| PRK09103 |
PRK09103 |
ribonucleoside-diphosphate reductase subunit alpha; |
1-740 |
8.74e-74 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 181649 [Multi-domain] Cd Length: 758 Bit Score: 256.07 E-value: 8.74e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 1 MFVYKRDGRQEKVAFDKITARVSRLCYGLDSDHVDPVEITQKVisGVYPGVTTIEL-DNLAAETAATMTTKHPDYAILAA 79
Cdd:PRK09103 2 LLVTKRDGRTERINLDKIHRVITWAAEGLHNVSVSQVELRSHI--QFYDGIKTSDIhETIIKAAADLISRDAPDYQYLAA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 80 RIAVSNLHKQTEKVFSTvvQQLHDYVNPktdkpapMISDKIYDivmKHK---------DELDSAIIYDRDFTYNFFGFKT 150
Cdd:PRK09103 80 RLAIFHLRKKAYGQFEP--PALYDHVVK-------MVEMGKYD---KHLledyteeefDQMDTFIDHWRDMNFSYAAVKQ 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 151 LERSYLL--RIDGKVAERPQHMIMRVAVGIHGE-DIEAAIET----YNLMSQryFTHASPTLFNAG--TPRPQLSSCFLV 221
Cdd:PRK09103 148 LEGKYLVqnRVTGEIYESAQFLYILVAACLFSNyPKETRLDYvkrfYDAVST--FKISLPTPIMSGvrTPTRQFSSCVLI 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 222 TMkDDSIEGIYDTLK-MCAMISKTAGgIGINIHNIRATGSYIAGTNGTSNGIVPMIRVYNNTARYVDQGGnKRPGAFAAY 300
Cdd:PRK09103 226 EC-GDSLDSINATSSaIVKYVSQRAG-IGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGG-VRGGAATLF 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 301 LEPWHADVMDFLELRKTHGNEDFRAREMFYALWIPDLFMQRVERNEQWTFFCPNEAPGLADVW---GDEFVALYEKYEKE 377
Cdd:PRK09103 303 YPIWHLEVESLLVLKNNRGVEENRVRHMDYGVQINKLMYQRLIKGGDITLFSPSDVPGLYDAFfadQDEFERLYTKYEQD 382
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 378 NRGR-RSLPAQKVWYAILQSQVETGNPFMLYKDSCNRKS--NQKnVGTIRCSNLCTEIVEYSSP--------DEVAVCNL 446
Cdd:PRK09103 383 DSIRkKRVKAVELFSLMMQERASTGRIYIQNVDHCNTHSpfDPK-VAPVRQSNLCLEIALPTKPlndvndenGEIALCTL 461
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 447 ASVALPTfIKdgkyNFQKLHDVVKVVTRNLNKIIDVNYYPVPEARRSNMRHRPVGLGVQGLADAFFALRLPFESAGAKKL 526
Cdd:PRK09103 462 SAFNLGA-IN----SLDELEELADLAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKNGVRYSDGSANNL 536
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 527 NIQIFETIYHAALEASCEIAQVEGTYESYEGSPASQGILQYDMWNVNPTDL------WDWAELKEKIAKHGIRNSLLVAP 600
Cdd:PRK09103 537 THKTFEAIQYYLLKASNELAKEQGACPWFNETTYAQGILPIDTYKKDLDAIcneplhYDWETLREEIKTHGLRNSTLSAL 616
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 601 MPTASTSQILGFNECFEPytsnmyQRRVLSGEFQivnpwllKDLVERdlwnedmknklvmldgsiQAIPEIPQdLKDLYK 680
Cdd:PRK09103 617 MPSETSSQISNATNGIEP------PRGYVSIKAS-------KDGILK------------------QVVPDYER-LKDAYE 664
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 681 TVWE------------ISQKtvidyaadrgpFIDQSQSLNIHLkDPS---YGKITSMHF-----YGWKKGLKTgMYYLRT 740
Cdd:PRK09103 665 LLWEmpnndgylqlvgIMQK-----------FVDQSISANTNY-DPSrfpSGKVPMKQLlkdllTAYKFGVKT-LYYHNT 731
|
|
| PRK06406 |
PRK06406 |
vitamin B12-dependent ribonucleotide reductase; |
75-712 |
4.24e-73 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 235796 [Multi-domain] Cd Length: 771 Bit Score: 254.39 E-value: 4.24e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 75 AILAARIAVSNL-HKQTEKVFSTVVQQLHDYVNPKTDKpapmISDKIYDIVMKHKDELD-------SAIIY--------- 137
Cdd:PRK06406 25 AIYKAMLSVKNGsMEDAEELTDKVVERLKKYERPTVEQ----IQDIVEKVLMTKKINGKdftdvakSYILYrekrrkire 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 138 ---------DRDFTYNffGFKTLERSYLLR-IDGKVAERPQHMIMRVAVGI----------------------------- 178
Cdd:PRK06406 101 ekeligvkdDLKLTLN--AIKVLEARYLLKdEDGKIIETPRQMFRRVARHIaivealyddevydktgkqkenaevigkls 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 179 ---------------------------------HGEDIEAAIET-YNLMSQRYFTHASPTLFNAGTPRPQLSSCFLVTMk 224
Cdd:PRK06406 179 vtqedmlkrafrylkeegimkgdfeefldflktKWDSIEEYINKfEEVMSNLKFVPNSPTLMNAGTKLGQLSACFVLPV- 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 225 DDSIEGIYDTLKMCAMISKTAGGIGINIHNIRATGSYIAGTNGTSNGIVPMIRVYNNTARYVDQGGnKRPGAFAAYLEPW 304
Cdd:PRK06406 258 PDSIEGIFNALKYTAMIHKSGGGTGFSFSRLRPKDDIVASTKGVASGPLSFMRIFDVTTDVIKQGG-KRRGANMGILSYH 336
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 305 HADVMDFLeLRKTHGNEDFRAREMFYAlwIPDLFMQRVERneqwtffcpneapgladvwgDEFVALYEKYEKENRGRrsL 384
Cdd:PRK06406 337 HPDIMEFI-TSKDSENKVLSNFNISVA--VTDEFFDKLDN--------------------DDYYPLRNPRNGKEVKR--I 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 385 PAQKVWYAILQSQVETGNPFMLYKDSCNRKSNQKNVGTIRCSNLCTE--IVEYSSpdevavCNLASVALPTFIKDGKYNF 462
Cdd:PRK06406 392 KARQVWDLIITQAWKTGDPGVIFLDEINRKNPVKNLGEIESTNPCGEqpLLPYES------CNLGSINLSKFVENGKIDW 465
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 463 QKLHDVVKVVTRNLNKIIDVNYYPVPEARRSNMRHRPVGLGVQGLADAFFALRLPFESAGAKKLNIQIFETIYHAALEAS 542
Cdd:PRK06406 466 DRLRETVHIATRFLDNVIDANKFPVPQIKEMTRMTRKIGLGVMGFADMLIKLGIPYNSEEALEIAEKVMKFINEESHRAS 545
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 543 CEIAQVEGTYESYEGSpasqgilqydmwnvnptdlwDWAelKEKIAkhgIRNSLLVAPMPTASTSQILGFNECFEPYTSN 622
Cdd:PRK06406 546 QKLAEERGVFPAWYGS--------------------EWE--KKGIK---MRNSTTTTIAPTGTISIIAGCSSSIEPLFAI 600
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 623 MYQRRVLSGEFQI-VNPWLLKDLVERDLWNEDMKNKlVMLDGSIQAIpEIPQDLKDLYKTVWEISQKTVIDYAADRGPFI 701
Cdd:PRK06406 601 AFVRHVLNGQELLeVNPLFEEITRKRGLYSEELMRK-VAETGNLQNI-DVPEDIKRIFVTAHEIDPQWHVLMQATFQRYC 678
|
730
....*....|.
gi 19115403 702 DQSQSLNIHLK 712
Cdd:PRK06406 679 DSGVSKTINLR 689
|
|
| PRK08332 |
PRK08332 |
vitamin B12-dependent ribonucleotide reductase; |
426-685 |
2.07e-37 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 181392 [Multi-domain] Cd Length: 1740 Bit Score: 151.84 E-value: 2.07e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 426 SNLCTE--IVEYSSpdevavCNLASVALPTFIK---DGK--YNFQKLHDVVKVVTRNLNKIIDVNYYPVPEARRSNMRHR 498
Cdd:PRK08332 1294 SHNCGEepLYEYES------CNLASINLAKFVKydeNGKpyFDWDEYAYVIQKVAKYLDNAIDVNKFPLPEIDYNTKLTR 1367
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 499 PVGLGVQGLADAFFALRLPFESAGAKKLNIQIFETIYHAALEASCEIAQVEGTYESYE------GSPASQGILQYDMWNV 572
Cdd:PRK08332 1368 RIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSVEAAKKRGTFPLYEkteypkGELPVEGFYHPEIWNL 1447
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 573 nptdlwDWAELKEKIAKHGIRNSLLVAPMPTASTSQILGFNECFEPYTSNMYQRRVLSGEFQIVNPWLLKDLVERDLWNE 652
Cdd:PRK08332 1448 ------PWDKLVEEIKKYGVRNAMVTTCPPTGSVSMIADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKKRGLYSE 1521
|
250 260 270
....*....|....*....|....*....|...
gi 19115403 653 DMKNKLVMLDGSIQAIPEIPQDLKDLYKTVWEI 685
Cdd:PRK08332 1522 ELLKKISDNYGSVQGLEEIPEDMQRVFVTALDI 1554
|
|
| PRK08115 |
PRK08115 |
vitamin B12-dependent ribonucleotide reductase; |
173-640 |
3.87e-34 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 236152 [Multi-domain] Cd Length: 858 Bit Score: 140.75 E-value: 3.87e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 173 RVAVGIHG-----EDIEAAIET-YNLMSQRYFTHASPTLFNAGTPRP-QLSSCFLVTMKDDSIEGIYDTLKMCAMISKTA 245
Cdd:PRK08115 137 RNATGLAAvekteEKRKESFEKfYQELVNMNFVPAGRVLYGAGSKTDvTYFNCYVMPFVKDSREGISEHRKQVMEIMSRG 216
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 246 GGIGINIHNIRATGSYIAGTNGTSNGIVPMIRVYNNTARYVDQGGNKRpGAFAAYLEPWHADVMDFL------------E 313
Cdd:PRK08115 217 GGVGTNGSTLRPRNTLARGVNGKSSGSVSWLDDIAKLTHLVEQGGSRR-GAQMIMLADWHPDILEFIiskmqnprilryL 295
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 314 LRKTHGNEDFRA--------------REMF--------------------------------YALWIPDL---------- 337
Cdd:PRK08115 296 LENTEDEQIKRLvkeklkftplseveEAMYqaivnykniegqggfdtkvikeaenklrtggtYTVNNPEFltganisvcl 375
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 338 ---FMQRVERNEQWTFFCPN-------EAPGLADVW---GDefVALYEKYEKENRGRRSLPAQKVWYAILQSQVETGNPF 404
Cdd:PRK08115 376 tkeFMEAVENDEEYELRFPDvenyteeEMEIYNEEWhevGD--VREWEKMGYPVRTYRKIKAKELWNLINICATYSAEPG 453
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 405 MLYKDSCNRKSNQKNVG-TIRCSNLCTE--IVEYSspdevaVCNLASVALPTFI--KDGKYNFQKLHDVVKVVTRNLNKI 479
Cdd:PRK08115 454 IFFIDNANEMTNAKAYGqKVVATNPCGEqpLAPYS------VCNLAAINLANMAdkETKTVDYEKLKRTVEVGVRMQDNV 527
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 480 IDVNYYPVPEARRSNMRHRPVGLGVQGLADAFFALRLPFESAGAKKLNIQIFETIYHAALEASCEIAQVEGTYESYEGSP 559
Cdd:PRK08115 528 IDATPYFLEENKKQALGERRVGLGVMGLHDLLIYCETVYGSEEGNQLVDQIFETIATTAYRTSIELAKEKGSFPFLVGQT 607
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 560 AS------QGILQYDMWNVNPTDlwdwaeLKEKIAKHGIRNSLLVAPMPTASTSQILGFNECFEPYTSNMYQRRVLSGEF 633
Cdd:PRK08115 608 EEetaklrEAFINTGYMKKMPED------IREDILKYGIRNSHLLTVAPTGSTGTMVGVSTGLEPYFSFSYYRSGRLGKF 681
|
570
....*....|..
gi 19115403 634 -----QIVNPWL 640
Cdd:PRK08115 682 ievkaDIVQEYL 693
|
|
| PRK06556 |
PRK06556 |
vitamin B12-dependent ribonucleotide reductase; Validated |
189-732 |
1.81e-33 |
|
vitamin B12-dependent ribonucleotide reductase; Validated
Pssm-ID: 235828 [Multi-domain] Cd Length: 953 Bit Score: 138.56 E-value: 1.81e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 189 TYNLMSQrYFTHASPTLFNAGTP-RPQLSSCFLVTMkDDSIEGIYDTLKMCAMISKTAGGIGINIHNIRATGSYIAGtNG 267
Cdd:PRK06556 123 TWLLLHQ-KFSFNSPVWFNVGTEsPQQVSACFILSV-DDSMESILNWYKEEGMLFKGGSGTGTNLSRIRSSKELLSG-GG 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 268 TSNGIVPMIRVYNNTARYVDQGGNKRPGAFAAYLEPWHADVMDFLE-----------LRKTHGNEDFRARE---MFY--- 330
Cdd:PRK06556 200 TASGPVSFMRGADASAGTIKSGGATRRAAKMVILDVDHPDIEEFIEtkakeedkiraLRDAGYDMDLGGEAyssVQYqna 279
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 331 --ALWIPDLFMQRVERNEQWTFfcpneapgladvwgdefvalyekyekenRGR------RSLPAQKVWYAILQSQVETGN 402
Cdd:PRK06556 280 nnSVRVSDEFMRAVENDGEFGL----------------------------RARtdgeviETVDAKELFRKIAEAAWECAD 331
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 403 PFMLYKDSCNRKSNQKNVGTIRCSNLCTEiveYSSPDEVAvCNLASVALPTFIK-DGKYNFQKLHDVVKVVTRNLNKIID 481
Cdd:PRK06556 332 PGIQYDDTINDWHTCPESGRINASNPCSE---YMFLDNSS-CNLASLNLMKFLRdDGTFDVESFRHAVELVITAMEISIC 407
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 482 VNYYPVPEARRSNMRHRPVGLGVQGLADAFFALRLPFESAGAKKLNIQIFETIYHAALEASCEIAQVEGTYESYE-GSPA 560
Cdd:PRK06556 408 FADFPTEKIARNTRAFRQLGLGYANLGALLMATGLPYDSDGGRALAAAITSLMTGEAYRRSAELAGVVGPFEGYArNAEP 487
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 561 SQGILQ--------YDMWNVNPTDLWD-----WAELKEKIAKHGIRNS--LLVAPMPTAS------TSQIlgfnecfEPY 619
Cdd:PRK06556 488 HLRVMRkhaaandaIRPLGEVDAALLEaakeaWDDALELGEKNGYRNAqaSVLAPTGTIGfmmdcdTTGI-------EPD 560
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 620 TSNM-YQRRVLSGEFQIVNPwllkdLVERDL----WNEDMKNKLV---MLDGSIQAIPeipqDLKDLYKTVWEISQKTV- 690
Cdd:PRK06556 561 FALVkYKKLVGGGSMKIVNQ-----TVPRALkklgYSEEQIEAIVeyiAEHGHIEGAP----GLKPEHYAVFDCAMKPAs 631
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....
gi 19115403 691 ----IDY-------AADRgPFIDQSQSLNIHL-KDPSYGKITSMHFYGWKKGLK 732
Cdd:PRK06556 632 gersISPmghvrmmAAVQ-PFLSGAISKTVNMpEDATVEDIEEVYLEGWKLGLK 684
|
|
| PRK06948 |
PRK06948 |
ribonucleotide reductase-like protein; Provisional |
201-755 |
6.00e-30 |
|
ribonucleotide reductase-like protein; Provisional
Pssm-ID: 180772 [Multi-domain] Cd Length: 595 Bit Score: 126.06 E-value: 6.00e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 201 ASPTLFNAGTPRPQ-LSSCF---------LVTMKDDSIEGIYDTLKMCAMisktAGGIGINIHNIRATGSYIAGTNGTSN 270
Cdd:PRK06948 70 AGRIMANAGAAPDQtMVNCFvhpirapaaLTAVHPNLDRALDDARLTLLM----GGGIGYDFSAIPPADARPDADHPDSP 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 271 GIVPMIRVYNNTARYVDQGGNKRpGAFAAYLEPWHADVMDFLELRKTHGnedfRAREMFYALWIPDLFMQRVERNEQWTF 350
Cdd:PRK06948 146 GVCAALDRFDRICAALPFRDGRR-GAQMAVLRCDHPDLLAFVAAKRGRA----RWTTFNLSVAVTDAFMQAVAQDLPWAL 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 351 F---CPNEAPGLADVWGDefvalyekyekenrGR---RSLPAQKVWYAILQSQVETGNPFMLYKDSCNRKSNQKNVGTIR 424
Cdd:PRK06948 221 RhraPPRRAAGGALRGAD--------------GAwtyATVPARHLWREIVSAARDSAEPGLLFVDTIDAANPLREHERID 286
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 425 CSNLCTE--IVEYSSpdevavCNLASVALPTFIK-----DGK--YNFQKLHDVVKVVTRNLNKIIDVNYYPVPEARRSNM 495
Cdd:PRK06948 287 ATNPCGEqpLPPYGS------CVLGPIDLSRFVRhpfgvGGEprFDFAALATAVRIQVRMLDNALDLTRWPLAAHAREAR 360
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 496 RHRPVGLGVQGLADAFFALRLPFESAGAKKLNIQIFETIYHAALEASCEIAQVEGTY-----ESYEGSPASQGILQYdmw 570
Cdd:PRK06948 361 QKRRIGVGVTGLADALTMMRLRYDSPAAREMARYIASDLRHHAYAASAALAAERGAYplcdpAAHLDALRAGPPLPH--- 437
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 571 nvnptdlwdwaELKEKIAKHGIRNSLLVAPMPTASTSQILGFNeC---FEPYTSNMYQRRVLSGEFQIvnpwllkdlveR 647
Cdd:PRK06948 438 -----------AVCHAIARHGLRNSHLLSFAPVGSVSLAFGDN-CspgIEPARAWIEHRPVRAGAGGA-----------R 494
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 648 DLWNEDMKNKLVM-LDGSIQAIPeipqdlkDLYKTVWEISQKTVIDYAADRGPFIDQSQSLNIHLKDP-SYGKITSMHFY 725
Cdd:PRK06948 495 GMRAENHAYRLFRsLRGERAALP-------DYFVTAADVAPADHLAMRAALQPYVDAGISKTVTLPNHySLAEVDALLFQ 567
|
570 580 590
....*....|....*....|....*....|
gi 19115403 726 GWKKGLKtGMYYLRTMAASAAIkFTVDPVA 755
Cdd:PRK06948 568 AWRAGLK-GITIFRPDPALDAV-PSDDDAV 595
|
|
| Ribonuc_red_lgN |
pfam00317 |
Ribonucleotide reductase, all-alpha domain; |
143-211 |
1.34e-23 |
|
Ribonucleotide reductase, all-alpha domain;
Pssm-ID: 459758 [Multi-domain] Cd Length: 75 Bit Score: 95.00 E-value: 1.34e-23
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19115403 143 YNFFGFKTLERSYLLRI-DGKVAERPQHMIMRVAVGIHG-----EDIEAAIETYNLMSQRYFTHASPTLFNAGTP 211
Cdd:pfam00317 1 LTYLGAKVLEDRYLLKDeDGELLETPQDMFMRVALALAGaeleeDRLELAEEFYDLLSSLKFLPATPTLMNAGTP 75
|
|
| ATP-cone |
pfam03477 |
ATP cone domain; |
1-89 |
3.35e-09 |
|
ATP cone domain;
Pssm-ID: 397513 [Multi-domain] Cd Length: 86 Bit Score: 54.19 E-value: 3.35e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 1 MFVYKRDGRQEKVAFDKITARVSRLCYGlDSDHVDPV--EITQKVISGVYPGVTTIELDNLaaetAATMTTKHPDYAILA 78
Cdd:pfam03477 1 MKVIKRDGRREPFDKEKIRRAIEKACEK-SPDQADELasEVEEELEKSLEDGISTEEIQDL----VEKTLAEHPDYAVAR 75
|
90
....*....|.
gi 19115403 79 ARIAVSNLHKQ 89
Cdd:pfam03477 76 AYILYRNLRKE 86
|
|
| RNR_PFL |
cd00576 |
Ribonucleotide reductase and Pyruvate formate lyase; Ribonucleotide reductase (RNR) and ... |
205-635 |
1.01e-07 |
|
Ribonucleotide reductase and Pyruvate formate lyase; Ribonucleotide reductase (RNR) and pyruvate formate lyase (PFL) are believed to have diverged from a common ancestor. They have a structurally similar ten-stranded alpha-beta barrel domain that hosts the active site, and are radical enzymes. RNRs are found in all organisms and provide the only mechanism by which nucleotides are converted to deoxynucleotides. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs use a diiron-tyrosyl radical while Class II RNRs use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. PFL, an essential enzyme in anaerobic bacteria, catalyzes the conversion of pyruvate and CoA to acteylCoA and formate in a mechanism that uses a glycyl radical.
Pssm-ID: 153083 [Multi-domain] Cd Length: 401 Bit Score: 55.23 E-value: 1.01e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 205 LFNAGTPRPQLSSCFLVT---MKDDSIEGIYDTLKM----CAMISK---------TAGGIGINIH--NIRATGSYIAG-T 265
Cdd:cd00576 12 VITVGRPDLPFTGCVLVDygdSLDPGIKGVNETAKSineaIQKTYQiialaasnqNGGGVSFARAssILSPYGSRDYAkG 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 266 NGTSNGIVPMIRVYNNTARYVDQGgNKRPGAFAAYLEPWHA-----DVMDFLELRKTHGNEDFRAREMFYALWIPDLFMQ 340
Cdd:cd00576 92 SGTETDAVEAADAFNLALKEVGQG-NGRTGAATGFIGGVHKgkgdkISQEFLNLALANGGEGIPLNFPNLSVRVSSDKPG 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 341 RVERNeqwtffcpneapgladvwgdefVALYEKYEKENRgrrslpaqkvwyailqsqvETGNPFMLykdscnrkSNQKNV 420
Cdd:cd00576 171 ILVKA----------------------VELKQLIAEEAR-------------------KTGSPGIF--------NDELCN 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 421 GtircsnlcteiveysspdeVAVcNLASVALPTFIKDGKYNFQKLHDVVKVVTRNLNKIIDVNYYPVPEARRSNMRHRPV 500
Cdd:cd00576 202 L-------------------VSL-NLARIMEKAINGSMDVVLEELEELAFLAVRALDCVIDSHDERIPTIELGGDERRTV 261
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 501 GLGVQGLADAFFALRLPF-ESAGAKKLNIQIFETIYHAALEASCE---IAQ--VEGTYESYEGSPASQGIlqydmwNVNP 574
Cdd:cd00576 262 GLGIAGVADLLIKLGLEKvGDPEADDLAAELVDQLKKHLVKATNErgfNFLlgLSPSESNSSGAPATNGV------SPSR 335
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19115403 575 ----TDLWDWAELKEKIAkhgirnslLVAPMPTASTSQILgFNECFEPYTSNMYQ-RRVLSGEFQI 635
Cdd:cd00576 336 g*iaIVLNGDIGPEESLA--------SVAILQFYADNGIS-DTITIPDSATNLDQlLAVIDGAAAI 392
|
|
| PRK08332 |
PRK08332 |
vitamin B12-dependent ribonucleotide reductase; |
184-247 |
9.59e-07 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 181392 [Multi-domain] Cd Length: 1740 Bit Score: 52.85 E-value: 9.59e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19115403 184 EAAIETY-NLMSQRYFTHASPTLFNAGTPRPQLSSCFLVTMKDDsIEGIYDTLKMCAMISKTAGG 247
Cdd:PRK08332 238 EKEIEEYfRLMTNQIFMPNTPALINSGRPLGMLSACFVVPIEDD-MESIMKAAHDVAMIQKAGGG 301
|
|
| PRK07562 |
PRK07562 |
vitamin B12-dependent ribonucleotide reductase; |
334-603 |
6.15e-05 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 236049 [Multi-domain] Cd Length: 1220 Bit Score: 46.88 E-value: 6.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 334 IPDLFMQRVERNEQWTffcpneapgladvwgdefvaLYEKyeKENRGRRSLPAQKVWYAILQSQVETGNPFMLYKDSCNR 413
Cdd:PRK07562 403 VTDEFLRAVENDGDWN--------------------LTAR--TDGKVAKTLKARDLWEKIGYAAWASADPGLQFNTTIND 460
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 414 KSNQKNVGTIRCSNLCTEiveYSSPDEVAvCNLASVALPTFIKDGKYNFQ--KLHDVVKVVTRNLNKIIDVNYYPVPE-A 490
Cdd:PRK07562 461 WHTCPASGPIRASNPCSE---YMFLDDTA-CNLASLNLLTFRDEDTKRFDveAYEHACRLWTVVLEISVLMAQFPSKEiA 536
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115403 491 RRSnMRHRPVGLGVQGLADAFFALRLPFESAGAKKLNIQIFETIYHAALEASCEIAQVEGTYESYEgsPASQGILQ---- 566
Cdd:PRK07562 537 ELS-YEFRTLGLGYANIGGLLMTMGIPYDSDEGRAICGALSAIMTGVAYATSAEMAKELGPFPGYE--KNADHMLRvirn 613
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19115403 567 -----------YDMWNVNPTDL-----------------WDWA-ELKEkiaKHGIRN--SLLVAPMPT 603
Cdd:PRK07562 614 hrraahgesegYEGLSVNPVPLdhancpdqdlvahakaaWDKAlELGE---KHGYRNaqVTVIAPTGT 678
|
|
| PRK08332 |
PRK08332 |
vitamin B12-dependent ribonucleotide reductase; |
249-316 |
5.30e-04 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 181392 [Multi-domain] Cd Length: 1740 Bit Score: 43.99 E-value: 5.30e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19115403 249 GINIHNIRATGSYIAGTNGTSNGIVPMIRVYNNTARYVDQGGNKRpGAFAAYLEPWHADVMDFLELRK 316
Cdd:PRK08332 757 GLNFSKLRPEGDIVGTTTGAASGPVSFMHLIDAVSDVIKQGGVRR-GANMGILEIWHPDIEKFIHAKE 823
|
|
| |
