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Conserved domains on  [gi|19115532|ref|NP_594620|]
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RNA polymerase II-associated Paf1 complex subunit Tpr1 [Schizosaccharomyces pombe]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 176-463 2.80e-17

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 83.24  E-value: 2.80e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  176 LGFLGKARILYAKGNYRSALKLYQRALVSNPQFkPDPRIGIGLCFWNLDMKTDALSAWTRVQQLDPKNTVVDTYIGLYYY 255
Cdd:COG2956    9 LGWYFKGLNYLLNGQPDKAIDLLEEALELDPET-VEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  256 DLafqnvnndsfvQNYGKALQHIQRAFKTRNNDPVASSILERYVYSKKNYEGCIKLAENVIQNSFSSsliADGYYWMGRA 335
Cdd:COG2956   88 KA-----------GLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPEN---AHAYCELAEL 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  336 YHQMGNNEKAMASYQKAKAADDRHLLSSVGIGQIQILQNDLTSAKLTFERIAEQNQSCFEALVVLGCLHASDSKPDltKA 415
Cdd:COG2956  154 YLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPE--EA 231

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 19115532  416 RMLLDRAFNLVGSsklprvvdSDLYITQARLW-EKEDTKKSLGFLTRAL 463
Cdd:COG2956  232 LELLRKALELDPS--------DDLLLALADLLeRKEGLEAALALLERQL 272
PEP_TPR_lipo super family cl37187
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 154-818 1.34e-13

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


The actual alignment was detected with superfamily member TIGR02917:

Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 75.51  E-value: 1.34e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    154 KESLENAARCFDFVLQKSGGNILGFLGKARILYAKGNYRSALKLYQRALVSNPQFKPDprigiglcfWNLdmKTD----- 228
Cdd:TIGR02917  138 LGQLELAQKSYEQALAIDPRSLYAKLGLAQLALAENRFDEARALIDEVLTADPGNVDA---------LLL--KGDlllsl 206

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    229 -----ALSAWTRVQQLDPKNTVVdtyiglyyydLAFQNVNNDSfVQNYGKALQHIQRAFKTRNNDPVASSILERYVYSKK 303
Cdd:TIGR02917  207 gnielALAAYRKAIALRPNNIAV----------LLALATILIE-AGEFEEAEKHADALLKKAPNSPLAHYLKALVDFQKK 275

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    304 NYEGCIKLAENVIQ---NSFSSSLIAdgyywmGRAYHQMGNNEKAMASYQKAKAADDRHLLSSVGIGQIQILQNDLTSAK 380
Cdd:TIGR02917  276 NYEDARETLQDALKsapEYLPALLLA------GASEYQLGNLEQAYQYLNQILKYAPNSHQARRLLASIQLRLGRVDEAI 349

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    381 LTFERIAEQNQSCFEALVVLGCLHAsdSKPDLTKARMLLDRAfnlvgSSKLPRVVDSDLYITQARLwEKEDTKKSLGFLT 460
Cdd:TIGR02917  350 ATLSPALGLDPDDPAALSLLGEAYL--ALGDFEKAAEYLAKA-----TELDPENAAARTQLGISKL-SQGDPSEAIADLE 421

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    461 RALD----------FLESAHM---------SVGPELLNNI---AVLQYHLGLIPEAHGNIIKAKSVLPDAnpeLSLLLDY 518
Cdd:TIGR02917  422 TAAQldpelgradlLLILSYLrsgqfdkalAAAKKLEKKQpdnASLHNLLGAIYLGKGDLAKAREAFEKA---LSIEPDF 498

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    519 -----NLARCEEELGNTSVASEAYVSILEKHPSFIDARIRKCLLQLSNPNEETFKE-IRHIMNADSQNLEVRAFFGWYLS 592
Cdd:TIGR02917  499 fpaaaNLARIDIQEGNPDDAIQRFEKVLTIDPKNLRAILALAGLYLRTGNEEEAVAwLEKAAELNPQEIEPALALAQYYL 578

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    593 KQKrRPVEDPEVRHCSQTLRHWHDDIYSLV---QLGNAYMRQAREfrVHNDREKL---------------KRQKLYIKAI 654
Cdd:TIGR02917  579 GKG-QLKKALAILNEAADAAPDSPEAWLMLgraQLAAGDLNKAVS--SFKKLLALqpdsalalllladayAVMKNYAKAI 655

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    655 QSYDQAIKFDPKNAHAAQGIAIILAQNRQFSKALLILSKVREA-IKDATTLINIGNCLAELKQFSRAIEVFETVYSSTGE 733
Cdd:TIGR02917  656 TSLKRALELKPDNTEAQIGLAQLLLAAKRTESAKKIAKSLQKQhPKAALGFELEGDLYLRQKDYPAAIQAYRKALKRAPS 735

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    734 SDTygvLSCLGRVWLQRGRESknvdylkESVRYATLALEKNPENPSLLFNVAFV---QFQLCELIR-------QKPENSR 803
Cdd:TIGR02917  736 SQN---AIKLHRALLASGNTA-------EAVKTLEAWLKTHPNDAVLRTALAELylaQKDYDKAIKhyqtvvkKAPDNAV 805

                          730
                   ....*....|....*
gi 19115532    804 TVEDLNFAMQQLDAS 818
Cdd:TIGR02917  806 VLNNLAWLYLELKDP 820
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 839-928 6.87e-06

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


:

Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 49.46  E-value: 6.87e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    839 EQRAKmAKNTTKRQLERAIQAQieyEKSVAAKLEDARIQREKEKARRLAEEEALLKEKQERERQLQEERQKMQEEVLEWR 918
Cdd:TIGR02794  108 EQAAK-QAEEKQKQAEEAKAKQ---AAEAKAKAEAEAERKAKEEAAKQAEEEAKAKAAAEAKKKAEEAKKKAEAEAKAKA 183

                           90
                   ....*....|
gi 19115532    919 KSQQKASEDD 928
Cdd:TIGR02794  184 EAEAKAKAEE 193
DUF5401 super family cl38662
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 850-1036 1.32e-05

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


The actual alignment was detected with superfamily member pfam17380:

Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 49.35  E-value: 1.32e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    850 KRQLERAIQAQIEYEKSVAAKLEDARIQREKEKARRLAEEEALLKEK-QERERQLQEERQKMQEEVLewRKSQQKASEDD 928
Cdd:pfam17380  359 KRELERIRQEEIAMEISRMRELERLQMERQQKNERVRQELEAARKVKiLEEERQRKIQQQKVEMEQI--RAEQEEARQRE 436

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    929 MSLSDDEEKQSGKKKKKDRKKRKSKSKQESSDSGVSEDDEIPLS-DARNKTKKRRVNRRVISEEYtfdqdsdaegnqEEE 1007
Cdd:pfam17380  437 VRRLEEERAREMERVRLEEQERQQQVERLRQQEEERKRKKLELEkEKRDRKRAEEQRRKILEKEL------------EER 504

                          170       180
                   ....*....|....*....|....*....
gi 19115532   1008 VSRTIEEKQDNDITDNQDDNKELNLFSEE 1036
Cdd:pfam17380  505 KQAMIEEERKRKLLEKEMEERQKAIYEEE 533
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 176-463 2.80e-17

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 83.24  E-value: 2.80e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  176 LGFLGKARILYAKGNYRSALKLYQRALVSNPQFkPDPRIGIGLCFWNLDMKTDALSAWTRVQQLDPKNTVVDTYIGLYYY 255
Cdd:COG2956    9 LGWYFKGLNYLLNGQPDKAIDLLEEALELDPET-VEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  256 DLafqnvnndsfvQNYGKALQHIQRAFKTRNNDPVASSILERYVYSKKNYEGCIKLAENVIQNSFSSsliADGYYWMGRA 335
Cdd:COG2956   88 KA-----------GLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPEN---AHAYCELAEL 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  336 YHQMGNNEKAMASYQKAKAADDRHLLSSVGIGQIQILQNDLTSAKLTFERIAEQNQSCFEALVVLGCLHASDSKPDltKA 415
Cdd:COG2956  154 YLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPE--EA 231

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 19115532  416 RMLLDRAFNLVGSsklprvvdSDLYITQARLW-EKEDTKKSLGFLTRAL 463
Cdd:COG2956  232 LELLRKALELDPS--------DDLLLALADLLeRKEGLEAALALLERQL 272
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 154-818 1.34e-13

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 75.51  E-value: 1.34e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    154 KESLENAARCFDFVLQKSGGNILGFLGKARILYAKGNYRSALKLYQRALVSNPQFKPDprigiglcfWNLdmKTD----- 228
Cdd:TIGR02917  138 LGQLELAQKSYEQALAIDPRSLYAKLGLAQLALAENRFDEARALIDEVLTADPGNVDA---------LLL--KGDlllsl 206

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    229 -----ALSAWTRVQQLDPKNTVVdtyiglyyydLAFQNVNNDSfVQNYGKALQHIQRAFKTRNNDPVASSILERYVYSKK 303
Cdd:TIGR02917  207 gnielALAAYRKAIALRPNNIAV----------LLALATILIE-AGEFEEAEKHADALLKKAPNSPLAHYLKALVDFQKK 275

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    304 NYEGCIKLAENVIQ---NSFSSSLIAdgyywmGRAYHQMGNNEKAMASYQKAKAADDRHLLSSVGIGQIQILQNDLTSAK 380
Cdd:TIGR02917  276 NYEDARETLQDALKsapEYLPALLLA------GASEYQLGNLEQAYQYLNQILKYAPNSHQARRLLASIQLRLGRVDEAI 349

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    381 LTFERIAEQNQSCFEALVVLGCLHAsdSKPDLTKARMLLDRAfnlvgSSKLPRVVDSDLYITQARLwEKEDTKKSLGFLT 460
Cdd:TIGR02917  350 ATLSPALGLDPDDPAALSLLGEAYL--ALGDFEKAAEYLAKA-----TELDPENAAARTQLGISKL-SQGDPSEAIADLE 421

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    461 RALD----------FLESAHM---------SVGPELLNNI---AVLQYHLGLIPEAHGNIIKAKSVLPDAnpeLSLLLDY 518
Cdd:TIGR02917  422 TAAQldpelgradlLLILSYLrsgqfdkalAAAKKLEKKQpdnASLHNLLGAIYLGKGDLAKAREAFEKA---LSIEPDF 498

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    519 -----NLARCEEELGNTSVASEAYVSILEKHPSFIDARIRKCLLQLSNPNEETFKE-IRHIMNADSQNLEVRAFFGWYLS 592
Cdd:TIGR02917  499 fpaaaNLARIDIQEGNPDDAIQRFEKVLTIDPKNLRAILALAGLYLRTGNEEEAVAwLEKAAELNPQEIEPALALAQYYL 578

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    593 KQKrRPVEDPEVRHCSQTLRHWHDDIYSLV---QLGNAYMRQAREfrVHNDREKL---------------KRQKLYIKAI 654
Cdd:TIGR02917  579 GKG-QLKKALAILNEAADAAPDSPEAWLMLgraQLAAGDLNKAVS--SFKKLLALqpdsalalllladayAVMKNYAKAI 655

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    655 QSYDQAIKFDPKNAHAAQGIAIILAQNRQFSKALLILSKVREA-IKDATTLINIGNCLAELKQFSRAIEVFETVYSSTGE 733
Cdd:TIGR02917  656 TSLKRALELKPDNTEAQIGLAQLLLAAKRTESAKKIAKSLQKQhPKAALGFELEGDLYLRQKDYPAAIQAYRKALKRAPS 735

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    734 SDTygvLSCLGRVWLQRGRESknvdylkESVRYATLALEKNPENPSLLFNVAFV---QFQLCELIR-------QKPENSR 803
Cdd:TIGR02917  736 SQN---AIKLHRALLASGNTA-------EAVKTLEAWLKTHPNDAVLRTALAELylaQKDYDKAIKhyqtvvkKAPDNAV 805

                          730
                   ....*....|....*
gi 19115532    804 TVEDLNFAMQQLDAS 818
Cdd:TIGR02917  806 VLNNLAWLYLELKDP 820
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 609-832 9.65e-13

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 72.33  E-value: 9.65e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  609 QTLRHWHDDIYSLVQLGNAYMRQAREFRVHNDREKLKRQKLYIKAIQSYDQAIKFDPKNAHAAQGIAIILAQNRQFSKAL 688
Cdd:COG3914   53 EAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEAL 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  689 LILskvREAIK----DATTLINIGNCLAELKQFSRAIEVFETVYSStgESDTYGVLSCLGRVWLQRGResknvdyLKESV 764
Cdd:COG3914  133 AAL---RRALAlnpdFAEAYLNLGEALRRLGRLEEAIAALRRALEL--DPDNAEALNNLGNALQDLGR-------LEEAI 200

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19115532  765 RYATLALEKNPENPSLLFNVAFVQFQLCELirqkpENSRTVEDLNFAMQQLDASIETFTKLVSVEHPP 832
Cdd:COG3914  201 AAYRRALELDPDNADAHSNLLFALRQACDW-----EVYDRFEELLAALARGPSELSPFALLYLPDDDP 263
tol_pal_ybgF TIGR02795
tol-pal system protein YbgF; Members of this protein family are the product of one of seven ...
 299-389 1.22e-06

tol-pal system protein YbgF; Members of this protein family are the product of one of seven genes regularly clustered in operons to encode the proteins of the tol-pal system, which is critical for maintaining the integrity of the bacterial outer membrane. The gene for this periplasmic protein has been designated orf2 and ybgF. All members of the seed alignment were from unique tol-pal gene regions from completed bacterial genomes. The architecture of this protein is a signal sequence, a low-complexity region usually rich in Asn and Gln, a well-conserved region with tandem repeats that resemble the tetratricopeptide (TPR) repeat, involved in protein-protein interaction.


Pssm-ID: 188247 [Multi-domain]  Cd Length: 117  Bit Score: 48.43  E-value: 1.22e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    299 VYSKKNYEGCIKLAENVIQNSFSSSLIADGYYWMGRAYHQMGNNEKAMASYQK--------AKAADDrhLLssvGIGQIQ 370
Cdd:TIGR02795   10 VLKAGDYADAIQAFQAFLKKYPKSTYAPNAHYWLGEAYYAQGDYADAAKAFLAvvkkypksPKAPDA--LL---KLGMSL 84

                           90
                   ....*....|....*....
gi 19115532    371 ILQNDLTSAKLTFERIAEQ 389
Cdd:TIGR02795   85 QELGDKEKAKATLQQVIKR 103
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 839-928 6.87e-06

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 49.46  E-value: 6.87e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    839 EQRAKmAKNTTKRQLERAIQAQieyEKSVAAKLEDARIQREKEKARRLAEEEALLKEKQERERQLQEERQKMQEEVLEWR 918
Cdd:TIGR02794  108 EQAAK-QAEEKQKQAEEAKAKQ---AAEAKAKAEAEAERKAKEEAAKQAEEEAKAKAAAEAKKKAEEAKKKAEAEAKAKA 183

                           90
                   ....*....|
gi 19115532    919 KSQQKASEDD 928
Cdd:TIGR02794  184 EAEAKAKAEE 193
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 850-1036 1.32e-05

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 49.35  E-value: 1.32e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    850 KRQLERAIQAQIEYEKSVAAKLEDARIQREKEKARRLAEEEALLKEK-QERERQLQEERQKMQEEVLewRKSQQKASEDD 928
Cdd:pfam17380  359 KRELERIRQEEIAMEISRMRELERLQMERQQKNERVRQELEAARKVKiLEEERQRKIQQQKVEMEQI--RAEQEEARQRE 436

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    929 MSLSDDEEKQSGKKKKKDRKKRKSKSKQESSDSGVSEDDEIPLS-DARNKTKKRRVNRRVISEEYtfdqdsdaegnqEEE 1007
Cdd:pfam17380  437 VRRLEEERAREMERVRLEEQERQQQVERLRQQEEERKRKKLELEkEKRDRKRAEEQRRKILEKEL------------EER 504

                          170       180
                   ....*....|....*....|....*....
gi 19115532   1008 VSRTIEEKQDNDITDNQDDNKELNLFSEE 1036
Cdd:pfam17380  505 KQAMIEEERKRKLLEKEMEERQKAIYEEE 533
CCDC66 pfam15236
Coiled-coil domain-containing protein 66; This protein family, named Coiled-coil ...
 854-926 1.62e-05

Coiled-coil domain-containing protein 66; This protein family, named Coiled-coil domain-containing protein 66 (CCDC) refers to a protein domain found in eukaryotes, and is approximately 160 amino acids in length. CCDC66 protein is detected mainly in the inner segments of photoreceptors in many vertebrates including mice and humans. It has been found in dogs, that a mutation in the CCDC66 gene causes generalized progressive retinal atrophy (gPRA). This shows that the protein encoded for by this gene is vital for healthy vision and guards against photoreceptor cell degeneration. The structure of CCDC66 proteins includes a heptad repeat pattern which contains at least one coiled-coil domain. There are at least two or more alpha-helices which form a cable-like structure.


Pssm-ID: 434558 [Multi-domain]  Cd Length: 154  Bit Score: 45.94  E-value: 1.62e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19115532    854 ERAIQAQIEYEKSVAAKLEDARIQREKEKARRLAEEeallkekQERERQLQEERQKMQEEVLEWRKSQQKASE 926
Cdd:pfam15236   48 ERKRQKALEHQNAIKKQLEEKERQKKLEEERRRQEE-------QEEEERLRREREEEQKQFEEERRKQKEKEE 113
PRK12704 PRK12704
phosphodiesterase; Provisional
 837-938 4.09e-04

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 44.38  E-value: 4.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532   837 SIEQRAKMAKNTTKRQL-----ERAIQAQIEYEKSVA------AKLEDARIQRE---KEKARRLAEEEALLKEKQERERQ 902
Cdd:PRK12704   42 RILEEAKKEAEAIKKEAlleakEEIHKLRNEFEKELRerrnelQKLEKRLLQKEenlDRKLELLEKREEELEKKEKELEQ 121

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 19115532   903 LQEERQKMQEEVLEWRKSQQKASEDDMSLSDDEEKQ 938
Cdd:PRK12704  122 KQQELEKKEEELEELIEEQLQELERISGLTAEEAKE 157
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 850-938 4.90e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 44.16  E-value: 4.90e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  850 KRQLERAIQAQIEYEKSVAAkLEDARIQREKEKARRLAEEEALLKEKQERERQLQEERQKMQEEVLEWRKSQQKASEDDM 929
Cdd:COG1196  385 AEELLEALRAAAELAAQLEE-LEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLE 463


                 ....*....
gi 19115532  930 SLSDDEEKQ 938
Cdd:COG1196  464 LLAELLEEA 472
PTZ00121 PTZ00121
MAEBL; Provisional
 793-1039 1.11e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.21  E-value: 1.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532   793 ELIRQKPENSRTVEDLNFAMQQLDASIETFTKLVSVEHPPYsptsiEQRAKMAKNTTKRQLERAIQA-QIEYEKSVAAKL 871
Cdd:PTZ00121 1561 EEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLY-----EEEKKMKAEEAKKAEEAKIKAeELKKAEEEKKKV 1635

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532   872 EDARIQREKE--KARRLAEEEALLKEKQERERQLQEERQKMQEEVLEWRKSQQKASEDDMSLSDDEEKQSGKKKKKDRKK 949
Cdd:PTZ00121 1636 EQLKKKEAEEkkKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEK 1715

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532   950 RKSKSKQESSDSGVSEDDEIPLSDARNKTK----------KRRVNRRVISEEYTFDQDSDA------EGNQEEEVSRTIE 1013
Cdd:PTZ00121 1716 KKAEELKKAEEENKIKAEEAKKEAEEDKKKaeeakkdeeeKKKIAHLKKEEEKKAEEIRKEkeavieEELDEEDEKRRME 1795

                         250       260       270
                  ....*....|....*....|....*....|.
gi 19115532  1014 -EKQDNDITDN----QDDNKELNLFSEEDEE 1039
Cdd:PTZ00121 1796 vDKKIKDIFDNfaniIEGGKEGNLVINDSKE 1826
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 839-1039 1.38e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 42.62  E-value: 1.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  839 EQRAKMAKNTTKRQLERAIQAQIEYEKSVAAKLEDARIQREKEKARRLAEEEALLKEKQERERQLQEERQKMQEEVLEWR 918
Cdd:COG1196  275 ELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELE 354

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  919 KSQQKASEDDMSLSDDEEKQSGKKKKKDRKKRKSKSKQESSDSGVSEDDEIPLSDARNKTKKRRVNRRVISEEytfdqDS 998
Cdd:COG1196  355 EAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELE-----EA 429

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 19115532  999 DAEGNQEEEVSRTIEEKQDNDITDNQDDNKELNLFSEEDEE 1039
Cdd:COG1196  430 LAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLE 470
TPR_8 pfam13181
Tetratricopeptide repeat;
326-352 3.07e-03

Tetratricopeptide repeat;


Pssm-ID: 404131 [Multi-domain]  Cd Length: 33  Bit Score: 36.22  E-value: 3.07e-03
                           10        20
                   ....*....|....*....|....*..
gi 19115532    326 ADGYYWMGRAYHQMGNNEKAMASYQKA 352
Cdd:pfam13181    1 AEAYYNLGLIYLKLGDYEEAKEYYEKA 27
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 176-463 2.80e-17

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 83.24  E-value: 2.80e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  176 LGFLGKARILYAKGNYRSALKLYQRALVSNPQFkPDPRIGIGLCFWNLDMKTDALSAWTRVQQLDPKNTVVDTYIGLYYY 255
Cdd:COG2956    9 LGWYFKGLNYLLNGQPDKAIDLLEEALELDPET-VEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  256 DLafqnvnndsfvQNYGKALQHIQRAFKTRNNDPVASSILERYVYSKKNYEGCIKLAENVIQNSFSSsliADGYYWMGRA 335
Cdd:COG2956   88 KA-----------GLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPEN---AHAYCELAEL 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  336 YHQMGNNEKAMASYQKAKAADDRHLLSSVGIGQIQILQNDLTSAKLTFERIAEQNQSCFEALVVLGCLHASDSKPDltKA 415
Cdd:COG2956  154 YLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPE--EA 231

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 19115532  416 RMLLDRAFNLVGSsklprvvdSDLYITQARLW-EKEDTKKSLGFLTRAL 463
Cdd:COG2956  232 LELLRKALELDPS--------DDLLLALADLLeRKEGLEAALALLERQL 272
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 154-818 1.34e-13

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 75.51  E-value: 1.34e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    154 KESLENAARCFDFVLQKSGGNILGFLGKARILYAKGNYRSALKLYQRALVSNPQFKPDprigiglcfWNLdmKTD----- 228
Cdd:TIGR02917  138 LGQLELAQKSYEQALAIDPRSLYAKLGLAQLALAENRFDEARALIDEVLTADPGNVDA---------LLL--KGDlllsl 206

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    229 -----ALSAWTRVQQLDPKNTVVdtyiglyyydLAFQNVNNDSfVQNYGKALQHIQRAFKTRNNDPVASSILERYVYSKK 303
Cdd:TIGR02917  207 gnielALAAYRKAIALRPNNIAV----------LLALATILIE-AGEFEEAEKHADALLKKAPNSPLAHYLKALVDFQKK 275

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    304 NYEGCIKLAENVIQ---NSFSSSLIAdgyywmGRAYHQMGNNEKAMASYQKAKAADDRHLLSSVGIGQIQILQNDLTSAK 380
Cdd:TIGR02917  276 NYEDARETLQDALKsapEYLPALLLA------GASEYQLGNLEQAYQYLNQILKYAPNSHQARRLLASIQLRLGRVDEAI 349

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    381 LTFERIAEQNQSCFEALVVLGCLHAsdSKPDLTKARMLLDRAfnlvgSSKLPRVVDSDLYITQARLwEKEDTKKSLGFLT 460
Cdd:TIGR02917  350 ATLSPALGLDPDDPAALSLLGEAYL--ALGDFEKAAEYLAKA-----TELDPENAAARTQLGISKL-SQGDPSEAIADLE 421

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    461 RALD----------FLESAHM---------SVGPELLNNI---AVLQYHLGLIPEAHGNIIKAKSVLPDAnpeLSLLLDY 518
Cdd:TIGR02917  422 TAAQldpelgradlLLILSYLrsgqfdkalAAAKKLEKKQpdnASLHNLLGAIYLGKGDLAKAREAFEKA---LSIEPDF 498

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    519 -----NLARCEEELGNTSVASEAYVSILEKHPSFIDARIRKCLLQLSNPNEETFKE-IRHIMNADSQNLEVRAFFGWYLS 592
Cdd:TIGR02917  499 fpaaaNLARIDIQEGNPDDAIQRFEKVLTIDPKNLRAILALAGLYLRTGNEEEAVAwLEKAAELNPQEIEPALALAQYYL 578

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    593 KQKrRPVEDPEVRHCSQTLRHWHDDIYSLV---QLGNAYMRQAREfrVHNDREKL---------------KRQKLYIKAI 654
Cdd:TIGR02917  579 GKG-QLKKALAILNEAADAAPDSPEAWLMLgraQLAAGDLNKAVS--SFKKLLALqpdsalalllladayAVMKNYAKAI 655

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    655 QSYDQAIKFDPKNAHAAQGIAIILAQNRQFSKALLILSKVREA-IKDATTLINIGNCLAELKQFSRAIEVFETVYSSTGE 733
Cdd:TIGR02917  656 TSLKRALELKPDNTEAQIGLAQLLLAAKRTESAKKIAKSLQKQhPKAALGFELEGDLYLRQKDYPAAIQAYRKALKRAPS 735

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    734 SDTygvLSCLGRVWLQRGRESknvdylkESVRYATLALEKNPENPSLLFNVAFV---QFQLCELIR-------QKPENSR 803
Cdd:TIGR02917  736 SQN---AIKLHRALLASGNTA-------EAVKTLEAWLKTHPNDAVLRTALAELylaQKDYDKAIKhyqtvvkKAPDNAV 805

                          730
                   ....*....|....*
gi 19115532    804 TVEDLNFAMQQLDAS 818
Cdd:TIGR02917  806 VLNNLAWLYLELKDP 820
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 609-832 9.65e-13

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 72.33  E-value: 9.65e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  609 QTLRHWHDDIYSLVQLGNAYMRQAREFRVHNDREKLKRQKLYIKAIQSYDQAIKFDPKNAHAAQGIAIILAQNRQFSKAL 688
Cdd:COG3914   53 EAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEAL 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  689 LILskvREAIK----DATTLINIGNCLAELKQFSRAIEVFETVYSStgESDTYGVLSCLGRVWLQRGResknvdyLKESV 764
Cdd:COG3914  133 AAL---RRALAlnpdFAEAYLNLGEALRRLGRLEEAIAALRRALEL--DPDNAEALNNLGNALQDLGR-------LEEAI 200

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19115532  765 RYATLALEKNPENPSLLFNVAFVQFQLCELirqkpENSRTVEDLNFAMQQLDASIETFTKLVSVEHPP 832
Cdd:COG3914  201 AAYRRALELDPDNADAHSNLLFALRQACDW-----EVYDRFEELLAALARGPSELSPFALLYLPDDDP 263
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
180-361 1.31e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 68.88  E-value: 1.31e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  180 GKARILYAKGNYRSALKLYQRALVSNPQFkPDPRIGIGLCFWNLDMKTDALSAWTRVQQLDPKNTVVDTYIGLYYYDLaf 259
Cdd:COG0457   13 NLGLAYRRLGRYEEAIEDYEKALELDPDD-AEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQAL-- 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  260 qnvnndsfvQNYGKALQHIQRAFKTRNNDPVASSILERYVYSKKNYEGCIKLAENVIQNSFSSsliADGYYWMGRAYHQM 339
Cdd:COG0457   90 ---------GRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDD---ADALYNLGIALEKL 157

                        170       180
                 ....*....|....*....|..
gi 19115532  340 GNNEKAMASYQKAKAADDRHLL 361
Cdd:COG0457  158 GRYEEALELLEKLEAAALAALL 179
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 42-781 1.94e-12

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 71.65  E-value: 1.94e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532     42 EILVNEQAPREFWTKFAHEYYIRGLREQAILILKSGLETLKDSESLCILNANIAaIYLSMAREAMLKKDT---------- 111
Cdd:TIGR02917  184 EVLTADPGNVDALLLKGDLLLSLGNIELALAAYRKAIALRPNNIAVLLALATIL-IEAGEFEEAEKHADAllkkapnspl 262

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    112 --------DLRDEQLRNVRTYLEAANNIDSKSEINVLLHGIYRILLNptdkeSLENAARCFDFVLQKSGGNILGFLGKAR 183
Cdd:TIGR02917  263 ahylkalvDFQKKNYEDARETLQDALKSAPEYLPALLLAGASEYQLG-----NLEQAYQYLNQILKYAPNSHQARRLLAS 337

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    184 ILYAKGNYRSALKLYQRALVSNPQfkpDPRI--GIGLCFWNLDMKTDALSAWTRVQQLDPKNTVVDTYIGLYYYDLafqn 261
Cdd:TIGR02917  338 IQLRLGRVDEAIATLSPALGLDPD---DPAAlsLLGEAYLALGDFEKAAEYLAKATELDPENAAARTQLGISKLSQ---- 410

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    262 vnNDSfvqnyGKALQHIQRAFKTRNNDPVASSIL-ERYVYSKKnYEGCIKLAENVIQNSFSSSLIadgYYWMGRAYHQMG 340
Cdd:TIGR02917  411 --GDP-----SEAIADLETAAQLDPELGRADLLLiLSYLRSGQ-FDKALAAAKKLEKKQPDNASL---HNLLGAIYLGKG 479

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    341 NNEKAMASYQKAKAADDRHLLSSVGIGQIQILQNDLTSAKLTFERIAEQNQSCFEALVVLGCLHASDSKPDltKARMLLD 420
Cdd:TIGR02917  480 DLAKAREAFEKALSIEPDFFPAAANLARIDIQEGNPDDAIQRFEKVLTIDPKNLRAILALAGLYLRTGNEE--EAVAWLE 557

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    421 RAFNLVGSSKLPRVVDSDLYItqarlwEKEDTKKSLGFLTRALDFLESAhmsvgPELLNNIAVLQYHLGLIPEAHGNIIK 500
Cdd:TIGR02917  558 KAAELNPQEIEPALALAQYYL------GKGQLKKALAILNEAADAAPDS-----PEAWLMLGRAQLAAGDLNKAVSSFKK 626

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    501 AKSVLPDANPELSLLLD-YNLARceeelgNTSVASEAYVSILEKHPSFIDARIRKCLLQLSNPNEETFKEIRHIMnadsq 579
Cdd:TIGR02917  627 LLALQPDSALALLLLADaYAVMK------NYAKAITSLKRALELKPDNTEAQIGLAQLLLAAKRTESAKKIAKSL----- 695

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    580 nlevraffgwylskQKRRPvEDPEVrhcsqtlrhwhddiysLVQLGNAYMRQARefrvhndreklkrqklYIKAIQSYDQ 659
Cdd:TIGR02917  696 --------------QKQHP-KAALG----------------FELEGDLYLRQKD----------------YPAAIQAYRK 728

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    660 AIKFDPkNAHAAQGIAIILAQNRQFSKAL-LILSKVREAIKDATTLINIGNCLAELKQFSRAIEVFETVYSStgESDTYG 738
Cdd:TIGR02917  729 ALKRAP-SSQNAIKLHRALLASGNTAEAVkTLEAWLKTHPNDAVLRTALAELYLAQKDYDKAIKHYQTVVKK--APDNAV 805

                          730       740       750       760
                   ....*....|....*....|....*....|....*....|...
gi 19115532    739 VLSCLGRVWLQRGResknvdylKESVRYATLALEKNPENPSLL 781
Cdd:TIGR02917  806 VLNNLAWLYLELKD--------PRALEYAERALKLAPNIPAIL 840
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 302-577 4.55e-10

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 61.67  E-value: 4.55e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  302 KKNYEGCIKLAENVIQNSFSSsliADGYYWMGRAYHQMGNNEKAMASYQKAKAADDRHLLSSVGIGQIQILQNDLTSAKL 381
Cdd:COG2956   21 NGQPDKAIDLLEEALELDPET---VEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEE 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  382 TFERIAEQNQSCFEALVVLGCLHASDSKPDltKARMLLDRAFNLVGSsklprvvDSDLYITQARLW-EKEDTKKSLGFLT 460
Cdd:COG2956   98 LLEKLLELDPDDAEALRLLAEIYEQEGDWE--KAIEVLERLLKLGPE-------NAHAYCELAELYlEQGDYDEAIEALE 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  461 RALdflesahmsvgpELLNNIAVLQYHLGLIPEAHGNIIKAKSVL---PDANPELSLLLdYNLARCEEELGNTSVASEAY 537
Cdd:COG2956  169 KAL------------KLDPDCARALLLLAELYLEQGDYEEAIAALeraLEQDPDYLPAL-PRLAELYEKLGDPEEALELL 235

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 19115532  538 VSILEKHPSFIDARIRKCLLQLSNPNEETFKEIRHIMNAD 577
Cdd:COG2956  236 RKALELDPSDDLLLALADLLERKEGLEAALALLERQLRRH 275
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
661-936 8.61e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 60.41  E-value: 8.61e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  661 IKFDPKNAHAAQGIAIILAQNRQFSKALLILSK-VREAIKDATTLINIGNCLAELKQFSRAIEVFETVYSStgESDTYGV 739
Cdd:COG0457    1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKaLELDPDDAEALYNLGLAYLRLGRYEEALADYEQALEL--DPDDAEA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  740 LSCLGRVWLQRGResknvdyLKESVRYATLALEKNPENPSLLFNVAFVQFQLcelirqkpensrtvedlnfamQQLDASI 819
Cdd:COG0457   79 LNNLGLALQALGR-------YEEALEDYDKALELDPDDAEALYNLGLALLEL---------------------GRYDEAI 130

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  820 ETFTKLVSVEhpPYSPTSIEQRAKMAKNTTKRQLERAIQAQIEYEKSVAAKLEDARIQREKEKARRLAEEEALLKEKQER 899
Cdd:COG0457  131 EAYERALELD--PDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALR 208

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 19115532  900 ERQLQEERQKMQEEVLEWRKSQQKASEDDMSLSDDEE 936
Cdd:COG0457  209 KKLAILTLAALAELLLLALALLLALRLAALALYQYRA 245
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 581-791 2.18e-09

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 59.74  E-value: 2.18e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  581 LEVRAFFGWYLSKQKRRPVEDPE--VRHCSQTLRHWHDDIYSLVQLGNAYMRQ---AREFRVHN-----DREKLK----- 645
Cdd:COG2956    3 LPVAAALGWYFKGLNYLLNGQPDkaIDLLEEALELDPETVEAHLALGNLYRRRgeyDRAIRIHQkllerDPDRAEallel 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  646 -----RQKLYIKAIQSYDQAIKFDPKNAHAAQGIAIILAQNRQFSKALLILSKVREAI-KDATTLINIGNCLAELKQFSR 719
Cdd:COG2956   83 aqdylKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGpENAHAYCELAELYLEQGDYDE 162

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19115532  720 AIEVFETVYSStgESDTYGVLSCLGRVWLQRGRESKNVDYLKEsvryatlALEKNPENPSLLFNVAFVQFQL 791
Cdd:COG2956  163 AIEALEKALKL--DPDCARALLLLAELYLEQGDYEEAIAALER-------ALEQDPDYLPALPRLAELYEKL 225
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 579-728 2.70e-09

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 61.16  E-value: 2.70e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  579 QNLEVRAFFGWYLSKQKRRPVEDPEVRHCSQTLRHWHddIYSLVQLGN-----AYMRQAREFR-----VHNDREK-LKRQ 647
Cdd:COG3914   48 LAALAEAAAAALLALAAGEAAAAAAALLLLAALLELA--ALLLQALGRyeealALYRRALALNpdnaeALFNLGNlLLAL 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  648 KLYIKAIQSYDQAIKFDPKNAHAAQGIAIILAQNRQFSKALLILskvREAIK----DATTLINIGNCLAELKQFSRAIEV 723
Cdd:COG3914  126 GRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAAL---RRALEldpdNAEALNNLGNALQDLGRLEEAIAA 202


                 ....*
gi 19115532  724 FETVY 728
Cdd:COG3914  203 YRRAL 207
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
210-389 1.33e-08

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 56.94  E-value: 1.33e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  210 PDPRIGIGLCFWNLDMKTDALSAWTRVQQLDPKNTVVDTYIGLYYYDLafqnvnndsfvQNYGKALQHIQRAFKTRNNDP 289
Cdd:COG0457    8 AEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRL-----------GRYEEALADYEQALELDPDDA 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  290 VASSILERYVYSKKNYEGCIKLAENVIQNSFSSsliADGYYWMGRAYHQMGNNEKAMASYQKAKAADDRHLLSSVGIGQI 369
Cdd:COG0457   77 EALNNLGLALQALGRYEEALEDYDKALELDPDD---AEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIA 153

                        170       180
                 ....*....|....*....|
gi 19115532  370 QILQNDLTSAKLTFERIAEQ 389
Cdd:COG0457  154 LEKLGRYEEALELLEKLEAA 173
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 616-740 4.42e-08

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 52.70  E-value: 4.42e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  616 DDIYSLVQLGNAYMRQARefrvhndreklkrqklYIKAIQSYDQAIKFDPKNAHAAQGIAIILAQNRQFSKALLILskvR 695
Cdd:COG4235   15 NDAEGWLLLGRAYLRLGR----------------YDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELL---E 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 19115532  696 EAIK----DATTLINIGNCLAELKQFSRAIEVFETVYSSTGESDTYGVL 740
Cdd:COG4235   76 RALAldpdNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLPADAPARLL 124
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 627-777 6.89e-08

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 52.50  E-value: 6.89e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  627 AYMRQAREFRVHNDREKlkrqklyikAIQSYDQAIKFDPKNAHAAQGIAIILAQNRQFSKALLILSKVREAI-KDATTLI 705
Cdd:COG4783    6 ALYALAQALLLAGDYDE---------AEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDpDEPEARL 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19115532  706 NIGNCLAELKQFSRAIEVFETVYSSTGESDTYGVLscLGRVWLQRGRESKNVDYLKEsvryatlALEKNPEN 777
Cdd:COG4783   77 NLGLALLKAGDYDEALALLEKALKLDPEHPEAYLR--LARAYRALGRPDEAIAALEK-------ALELDPDD 139
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 300-389 7.93e-08

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 51.53  E-value: 7.93e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  300 YSKKNYEGCIKLAENVIQNSFSSSLIADGYYWMGRAYHQMGNNEKAMASYQKAKAADDRHLLSS---VGIGQIQILQNDL 376
Cdd:COG1729    4 LKAGDYDEAIAAFKAFLKRYPNSPLAPDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPKAPdalLKLGLSYLELGDY 83

                         90
                 ....*....|...
gi 19115532  377 TSAKLTFERIAEQ 389
Cdd:COG1729   84 DKARATLEELIKK 96
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 324-595 8.29e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 54.74  E-value: 8.29e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  324 LIADGYYWMGRAYHQMGNNEKAMASYQKAKAADDRHLLSSVGIGQIQILQNDLTSAKLTFERIAEQNQSCFEALVVLGCL 403
Cdd:COG2956    6 AAALGWYFKGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQD 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  404 HASDSKPDltKARMLLDRAFNLVGSsklprvvDSDLYITQARLWEKE-DTKKSLGFLTRALD-FLESAHmsvgpeLLNNI 481
Cdd:COG2956   86 YLKAGLLD--RAEELLEKLLELDPD-------DAEALRLLAEIYEQEgDWEKAIEVLERLLKlGPENAH------AYCEL 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  482 AVLQYHLGLIPEAHGNIIKAKSVLPDaNPELSLLldynLARCEEELGNTSVASEAYVSILEKHPSFIDA--RIRKCLLQL 559
Cdd:COG2956  151 AELYLEQGDYDEAIEALEKALKLDPD-CARALLL----LAELYLEQGDYEEAIAALERALEQDPDYLPAlpRLAELYEKL 225

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 19115532  560 SNPnEETFKEIRHIMNADSQNLEVRAFFGWYLSKQK 595
Cdd:COG2956  226 GDP-EEALELLRKALELDPSDDLLLALADLLERKEG 260
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 168-297 1.79e-07

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 51.16  E-value: 1.79e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  168 LQKSGGNILGFLGKARILYAKGNYRSALKLYQRALVSNPQfKPDPRIGIGLCFWNLDMKTDALSAWTRVQQLDPKNTVVD 247
Cdd:COG4235   10 LAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPD-NADALLDLAEALLAAGDTEEAEELLERALALDPDNPEAL 88

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 19115532  248 TYIGLYYYDLafqnvnndsfvQNYGKALQHIQRAFKTRNNDPVASSILER 297
Cdd:COG4235   89 YLLGLAAFQQ-----------GDYAEAIAAWQKLLALLPADAPARLLEAS 127
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
541-773 2.36e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 53.09  E-value: 2.36e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  541 LEKHPSFIDARIRK--CLLQLSNPnEETFKEIRHIMNADSQNLEVRAFFGWYLSKQKRRpveDPEVRHCSQTLRHWHDDI 618
Cdd:COG0457    1 LELDPDDAEAYNNLglAYRRLGRY-EEAIEDYEKALELDPDDAEALYNLGLAYLRLGRY---EEALADYEQALELDPDDA 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  619 YSLVQLGNAYMRQARefrvhndreklkrqklYIKAIQSYDQAIKFDPKNAHAAQGIAIILAQNRQFSKALLILSKVRE-A 697
Cdd:COG0457   77 EALNNLGLALQALGR----------------YEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALElD 140

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19115532  698 IKDATTLINIGNCLAELKQFSRAIEVFETVYSSTGESDTYGVLSCLGRVWLQRGRESKNVDYLKESVRYATLALEK 773
Cdd:COG0457  141 PDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTL 216
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
326-527 2.86e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 52.70  E-value: 2.86e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  326 ADGYYWMGRAYHQMGNNEKAMASYQKAKAADDRHLLSSVGIGQIQILQNDLTSAKLTFERIAEQNQSCFEALVVLGCLHA 405
Cdd:COG0457    8 AEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQ 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  406 SDSKPDltKARMLLDRAFNLvgssklpRVVDSDLYITQARLWEK-EDTKKSLGFLTRALDfLESAHmsvgPELLNNIAVL 484
Cdd:COG0457   88 ALGRYE--EALEDYDKALEL-------DPDDAEALYNLGLALLElGRYDEAIEAYERALE-LDPDD----ADALYNLGIA 153

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 19115532  485 QYHLGLIPEAHGNIIKAKSVLPDANPELSLLLDYNLARCEEEL 527
Cdd:COG0457  154 LEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVL 196
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 98-356 4.20e-07

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 54.23  E-value: 4.20e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532   98 YLSMAREAMLKKDTDLRDEQLRNVRTYLEAANNIDSKSEINVLLHGIYRILLNPTDKESLENAARCFDFVLQKSGGNILG 177
Cdd:COG3914    1 AAAAALLALAALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  178 FLGKARILYAKGNYRSALKLYQRALVSNPQFkPDPRIGIGLCFWNLDMKTDALSAWTRVQQLDPKNTVVDTYIGLYYYDL 257
Cdd:COG3914   81 LELAALLLQALGRYEEALALYRRALALNPDN-AEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  258 afqnvnndsfvQNYGKALQHIQRAFKTRNNDPVAssileryvyskknyegciklaenviqnsfsssliadgYYWMGRAYH 337
Cdd:COG3914  160 -----------GRLEEAIAALRRALELDPDNAEA-------------------------------------LNNLGNALQ 191

                        250
                 ....*....|....*....
gi 19115532  338 QMGNNEKAMASYQKAKAAD 356
Cdd:COG3914  192 DLGRLEEAIAAYRRALELD 210
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 326-439 5.76e-07

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 49.62  E-value: 5.76e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  326 ADGYYWMGRAYHQMGNNEKAMASYQKAKAADDRHLLSSVGIGQIQILQNDLTSAKLTFERIAEQNQSCFEALVVLGCLHA 405
Cdd:COG4235   17 AEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAF 96

                         90       100       110
                 ....*....|....*....|....*....|....
gi 19115532  406 SDSKPDltKARMLLDRAFNLVGSSKLPRVVDSDL 439
Cdd:COG4235   97 QQGDYA--EAIAAWQKLLALLPADAPARLLEASI 128
tol_pal_ybgF TIGR02795
tol-pal system protein YbgF; Members of this protein family are the product of one of seven ...
 299-389 1.22e-06

tol-pal system protein YbgF; Members of this protein family are the product of one of seven genes regularly clustered in operons to encode the proteins of the tol-pal system, which is critical for maintaining the integrity of the bacterial outer membrane. The gene for this periplasmic protein has been designated orf2 and ybgF. All members of the seed alignment were from unique tol-pal gene regions from completed bacterial genomes. The architecture of this protein is a signal sequence, a low-complexity region usually rich in Asn and Gln, a well-conserved region with tandem repeats that resemble the tetratricopeptide (TPR) repeat, involved in protein-protein interaction.


Pssm-ID: 188247 [Multi-domain]  Cd Length: 117  Bit Score: 48.43  E-value: 1.22e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    299 VYSKKNYEGCIKLAENVIQNSFSSSLIADGYYWMGRAYHQMGNNEKAMASYQK--------AKAADDrhLLssvGIGQIQ 370
Cdd:TIGR02795   10 VLKAGDYADAIQAFQAFLKKYPKSTYAPNAHYWLGEAYYAQGDYADAAKAFLAvvkkypksPKAPDA--LL---KLGMSL 84

                           90
                   ....*....|....*....
gi 19115532    371 ILQNDLTSAKLTFERIAEQ 389
Cdd:TIGR02795   85 QELGDKEKAKATLQQVIKR 103
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 157-283 1.89e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 48.26  E-value: 1.89e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  157 LENAARCFDFVLQKSGGNILGFLGKARILYAKGNYRSALKLYQRALVSNPQFkPDPRIGIGLCFWNLDMKTDALSAWTRV 236
Cdd:COG4783   20 YDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDE-PEARLNLGLALLKAGDYDEALALLEKA 98

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 19115532  237 QQLDPKNTVVDTYIGLYYYDLafqnvnndsfvQNYGKALQHIQRAFK 283
Cdd:COG4783   99 LKLDPEHPEAYLRLARAYRAL-----------GRPDEAIAALEKALE 134
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 652-778 3.27e-06

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 47.31  E-value: 3.27e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  652 KAIQSYDQAIKFDPKNAHAAQGIAIILAQNRQFSKALLILSKVRE-AIKDATTLINIGNCLAELKQFSRAIEVFETVYSS 730
Cdd:COG4235    1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRlDPDNADALLDLAEALLAAGDTEEAEELLERALAL 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 19115532  731 tgESDTYGVLSCLGRVWLQRGRESKNVDYLKEsvryatlALEKNPENP 778
Cdd:COG4235   81 --DPDNPEALYLLGLAAFQQGDYAEAIAAWQK-------LLALLPADA 119
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
646-725 3.31e-06

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 46.32  E-value: 3.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  646 RQKLYIKAIQSYDQAIKFDPKNAHAAQGIAIILAQNRQFSKALLILSKVREAIKDATTLINIGNCLAELKQFSRAIEVFE 725
Cdd:COG3063    4 KLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIALEKALKLDPNNAEALLNLAELLLELGDYDEALAYLE 83
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
300-525 5.05e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 49.23  E-value: 5.05e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  300 YSKKNYEGCIKLAENVIQNSFSSsliADGYYWMGRAYHQMGNNEKAMASYQKAKAADDRHLLSSVGIGQIQILQNDLTSA 379
Cdd:COG0457   19 RRLGRYEEAIEDYEKALELDPDD---AEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEA 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  380 KLTFERIAEQNQSCFEALVVLGCLHASDSKPDltKARMLLDRAFNLVGSsklprvvDSDLYITQARLWEKedtkksLGFL 459
Cdd:COG0457   96 LEDYDKALELDPDDAEALYNLGLALLELGRYD--EAIEAYERALELDPD-------DADALYNLGIALEK------LGRY 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19115532  460 TRALDFLESAHMSVGPELLNNIAVLQYHLGLIPEAHGNIIKAKSVLPDANPELSLLLDYNLARCEE 525
Cdd:COG0457  161 EEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLA 226
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 157-243 6.67e-06

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 46.54  E-value: 6.67e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  157 LENAARCFDFVLQKSGGNILGFLGKARILYAKGNYRSALKLYQRALVSNPQFkPDPRIGIGLCFWNLDMKTDALSAWTRV 236
Cdd:COG4235   33 YDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDN-PEALYLLGLAAFQQGDYAEAIAAWQKL 111


                 ....*..
gi 19115532  237 QQLDPKN 243
Cdd:COG4235  112 LALLPAD 118
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 839-928 6.87e-06

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 49.46  E-value: 6.87e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    839 EQRAKmAKNTTKRQLERAIQAQieyEKSVAAKLEDARIQREKEKARRLAEEEALLKEKQERERQLQEERQKMQEEVLEWR 918
Cdd:TIGR02794  108 EQAAK-QAEEKQKQAEEAKAKQ---AAEAKAKAEAEAERKAKEEAAKQAEEEAKAKAAAEAKKKAEEAKKKAEAEAKAKA 183

                           90
                   ....*....|
gi 19115532    919 KSQQKASEDD 928
Cdd:TIGR02794  184 EAEAKAKAEE 193
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 270-390 8.86e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 46.34  E-value: 8.86e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  270 NYGKALQHIQRAFKTRNNDPVASSILERYVYSKKNYEGCIKLAENVIQNSFSSSLIadgYYWMGRAYHQMGNNEKAMASY 349
Cdd:COG4783   19 DYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEA---RLNLGLALLKAGDYDEALALL 95

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 19115532  350 QKAKAADDRHLLSSVGIGQIQILQNDLTSAKLTFERIAEQN 390
Cdd:COG4783   96 EKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELD 136
type_IV_pilW TIGR02521
type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF ...
 622-789 9.78e-06

type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF and PilW. This outer membrane protein is required both for pilus stability and for pilus function such as adherence to human cells. Members of this family contain copies of the TPR (tetratricopeptide repeat) domain.


Pssm-ID: 131573 [Multi-domain]  Cd Length: 234  Bit Score: 48.10  E-value: 9.78e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    622 VQLGNAYMRQARefrvhndreklkrqklYIKAIQSYDQAIKFDPKNAHAAQGIAIILAQNRQFSKALLILskvREAI--- 698
Cdd:TIGR02521   35 VQLALGYLEQGD----------------LEVAKENLDKALEHDPDDYLAYLALALYYQQLGELEKAEDSF---RRALtln 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    699 -KDATTLINIGNCLAELKQFSRAIEVFETVYSSTGESDTYGVLSCLGRVWLQRGRESKNVDYLKEsvryatlALEKNPEN 777
Cdd:TIGR02521   96 pNNGDVLNNYGTFLCQQGKYEQAMQQFEQAIEDPLYPQPARSLENAGLCALKAGDFDKAEKYLTR-------ALQIDPQR 168

                          170
                   ....*....|..
gi 19115532    778 PSLLFNVAFVQF 789
Cdd:TIGR02521  169 PESLLELAELYY 180
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 211-356 1.23e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 45.95  E-value: 1.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  211 DPRIGIGLCFWNLDMKTDALSAWTRVQQLDPKNTVVDTYIGLYYYDLafqnvnndsfvQNYGKALQHIQRAFKTRNNDPV 290
Cdd:COG4783    5 EALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQL-----------GDLDEAIVLLHEALELDPDEPE 73

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19115532  291 ASSILERYVYSKKNYEGCIKLAENVIQNSFSSsliADGYYWMGRAYHQMGNNEKAMASYQKAKAAD 356
Cdd:COG4783   74 ARLNLGLALLKAGDYDEALALLEKALKLDPEH---PEAYLRLARAYRALGRPDEAIAALEKALELD 136
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 850-1036 1.32e-05

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 49.35  E-value: 1.32e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    850 KRQLERAIQAQIEYEKSVAAKLEDARIQREKEKARRLAEEEALLKEK-QERERQLQEERQKMQEEVLewRKSQQKASEDD 928
Cdd:pfam17380  359 KRELERIRQEEIAMEISRMRELERLQMERQQKNERVRQELEAARKVKiLEEERQRKIQQQKVEMEQI--RAEQEEARQRE 436

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    929 MSLSDDEEKQSGKKKKKDRKKRKSKSKQESSDSGVSEDDEIPLS-DARNKTKKRRVNRRVISEEYtfdqdsdaegnqEEE 1007
Cdd:pfam17380  437 VRRLEEERAREMERVRLEEQERQQQVERLRQQEEERKRKKLELEkEKRDRKRAEEQRRKILEKEL------------EER 504

                          170       180
                   ....*....|....*....|....*....
gi 19115532   1008 VSRTIEEKQDNDITDNQDDNKELNLFSEE 1036
Cdd:pfam17380  505 KQAMIEEERKRKLLEKEMEERQKAIYEEE 533
CCDC66 pfam15236
Coiled-coil domain-containing protein 66; This protein family, named Coiled-coil ...
 854-926 1.62e-05

Coiled-coil domain-containing protein 66; This protein family, named Coiled-coil domain-containing protein 66 (CCDC) refers to a protein domain found in eukaryotes, and is approximately 160 amino acids in length. CCDC66 protein is detected mainly in the inner segments of photoreceptors in many vertebrates including mice and humans. It has been found in dogs, that a mutation in the CCDC66 gene causes generalized progressive retinal atrophy (gPRA). This shows that the protein encoded for by this gene is vital for healthy vision and guards against photoreceptor cell degeneration. The structure of CCDC66 proteins includes a heptad repeat pattern which contains at least one coiled-coil domain. There are at least two or more alpha-helices which form a cable-like structure.


Pssm-ID: 434558 [Multi-domain]  Cd Length: 154  Bit Score: 45.94  E-value: 1.62e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19115532    854 ERAIQAQIEYEKSVAAKLEDARIQREKEKARRLAEEeallkekQERERQLQEERQKMQEEVLEWRKSQQKASE 926
Cdd:pfam15236   48 ERKRQKALEHQNAIKKQLEEKERQKKLEEERRRQEE-------QEEEERLRREREEEQKQFEEERRKQKEKEE 113
DDRGK pfam09756
DDRGK domain; This is a family of proteins of approximately 300 residues, found in plants and ...
 840-938 1.83e-05

DDRGK domain; This is a family of proteins of approximately 300 residues, found in plants and vertebrates. They contain a highly conserved DDRGK motif.


Pssm-ID: 370664 [Multi-domain]  Cd Length: 188  Bit Score: 46.57  E-value: 1.83e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    840 QRAKMAKNTTKRQLERAIQAQIEYEKsvaaKLEDariQREKEKARRLAEEEALLKEKQERERQLQEER-QKMQEEVLEWR 918
Cdd:pfam09756    7 KRAKLELKEAKRQQREAEEEEREERE----KLEE---KREEEYKEREEREEEAEKEKEEEERKQEEEQeRKEQEEYEKLK 79

                           90       100
                   ....*....|....*....|
gi 19115532    919 KSQQKASEDDMSLSDDEEKQ 938
Cdd:pfam09756   80 SQFVVEEEGTDKLSAEDESQ 99
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 644-725 2.73e-05

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 45.34  E-value: 2.73e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  644 LKRQKLYIKAIQSYDQAIKFDPKNAHAAQGIAIILAQNRQFSKALLILSKVREAI-KDATTLINIGNCLAELKQFSRAIE 722
Cdd:COG5010   64 YNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSpDNPNAYSNLAALLLSLGQDDEAKA 143


                 ...
gi 19115532  723 VFE 725
Cdd:COG5010  144 ALQ 146
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
626-729 3.18e-05

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 46.45  E-value: 3.18e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  626 NAYMRQAREFRVHNDR-EKLKRQKLYIKAIQSYDQAIKFDPKNAHAAQGIAIILAQNRQFSKAlliLSKVREAI----KD 700
Cdd:COG4785   64 DRALALPDLAQLYYERgVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAA---LEDFDRALeldpDY 140

                         90       100
                 ....*....|....*....|....*....
gi 19115532  701 ATTLINIGNCLAELKQFSRAIEVFETVYS 729
Cdd:COG4785  141 AYAYLNRGIALYYLGRYELAIADLEKALE 169
MAP7 pfam05672
MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is ...
 874-938 5.10e-05

MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilising protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.


Pssm-ID: 461709 [Multi-domain]  Cd Length: 153  Bit Score: 44.65  E-value: 5.10e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19115532    874 ARIQREKEKARRLAEEEALLKEKQERERQLQEERQKMQEEVLEwRKSQQKASEDDMSLSDDEEKQ 938
Cdd:pfam05672   23 AREQREREEQERLEKEEEERLRKEELRRRAEEERARREEEARR-LEEERRREEEERQRKAEEEAE 86
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 61-253 6.48e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 45.88  E-value: 6.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532   61 YYIRGLREQAILILKSGLETLKDSESLCIlnaNIAAIYLSMAR----EAMLKKDTDLRD-------------EQLRN--- 120
Cdd:COG2956   52 YRRRGEYDRAIRIHQKLLERDPDRAEALL---ELAQDYLKAGLldraEELLEKLLELDPddaealrllaeiyEQEGDwek 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  121 -VRTYLEAANNIDSKSEINVLLHGIYRillnptDKESLENAARCFDFVLQKSGGNILGFLGKARILYAKGNYRSALKLYQ 199
Cdd:COG2956  129 aIEVLERLLKLGPENAHAYCELAELYL------EQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALE 202

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 19115532  200 RALVSNPQFKPDpRIGIGLCFWNLDMKTDALSAWTRVQQLDPKNTVVDTYIGLY 253
Cdd:COG2956  203 RALEQDPDYLPA-LPRLAELYEKLGDPEEALELLRKALELDPSDDLLLALADLL 255
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 840-913 9.95e-05

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 45.61  E-value: 9.95e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 19115532    840 QRAKMAKNTTKRQLERAIQAQIEYEKSVAAKLEDARIQREKEKARRLAEEEALLKEKQERERQLQEERQKMQEE 913
Cdd:TIGR02794   81 EKQRAAEQARQKELEQRAAAEKAAKQAEQAAKQAEEKQKQAEEAKAKQAAEAKAKAEAEAERKAKEEAAKQAEE 154
Caldesmon pfam02029
Caldesmon;
839-936 1.05e-04

Caldesmon;


Pssm-ID: 460421 [Multi-domain]  Cd Length: 495  Bit Score: 46.01  E-value: 1.05e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    839 EQRAKMAKNTTkRQLERAIQAQIEyeksvaAKLEDARIQREKEKARRLAEEEALLKEKQERERQL--QEERQKMQEEvLE 916
Cdd:pfam02029  252 ELRRRRQEKES-EEFEKLRQKQQE------AELELEELKKKREERRKLLEEEEQRRKQEEAERKLreEEEKRRMKEE-IE 323

                           90       100
                   ....*....|....*....|....*
gi 19115532    917 WRKSQ-----QKASEDdmSLSDDEE 936
Cdd:pfam02029  324 RRRAEaaekrQKLPED--SSSEGKK 346
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 470-688 1.27e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 46.14  E-value: 1.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  470 HMSVGPELLNNIAVLQYHLGLIPEAHGNIIKAKSVLPDANPELSLLLDYNLARCEEELGNTSVASEAYVSILEKHPSFID 549
Cdd:COG3914    1 AAAAALLALAALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  550 ARIRKCLLQLSNPNEETFKEIRHIMNADSQNLEVRAFFGWYLSKQKRRpveDPEVRHCSQTLRHWHDDIYSLVQLGNAYM 629
Cdd:COG3914   81 LELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRL---EEALAALRRALALNPDFAEAYLNLGEALR 157

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 19115532  630 RQARefrvhndreklkrqklYIKAIQSYDQAIKFDPKNAHAAQGIAIILAQNRQFSKAL 688
Cdd:COG3914  158 RLGR----------------LEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAI 200
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 300-425 1.35e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 42.87  E-value: 1.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  300 YSKKNYEGCIKLAENVIQNSFSSsliADGYYWMGRAYHQMGNNEKAMASYQKAKAADDRHLLSSVGIGQIQILQNDLTSA 379
Cdd:COG4783   15 LLAGDYDEAEALLEKALELDPDN---PEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEA 91

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 19115532  380 KLTFERIAEQNQSCFEALVVLGCLHASDSKPDltKARMLLDRAFNL 425
Cdd:COG4783   92 LALLEKALKLDPEHPEAYLRLARAYRALGRPD--EAIAALEKALEL 135
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 839-937 1.39e-04

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 45.71  E-value: 1.39e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    839 EQRAKMAKNTTKR--------------QLERAIQAQIEYEKSVAAKLEDARI--QREKEKARRLAEEEA----LLKEKQE 898
Cdd:pfam15709  340 AERAEMRRLEVERkrreqeeqrrlqqeQLERAEKMREELELEQQRRFEEIRLrkQRLEEERQRQEEEERkqrlQLQAAQE 419

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 19115532    899 RERQLQEE---------RQKMQEEVLEWRKSQQKASEDDMSLSDDEEK 937
Cdd:pfam15709  420 RARQQQEEfrrklqelqRKKQQEEAERAEAEKQRQKELEMQLAEEQKR 467
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 326-425 1.44e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 42.87  E-value: 1.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  326 ADGYYWMGRAYHQMGNNEKAMASYQKAKAADDRHLLSSVGIGQIQILQNDLTSAKLTFERIAEQNQSCFEALVVLGCLHA 405
Cdd:COG4783    4 AEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALL 83

                         90       100
                 ....*....|....*....|
gi 19115532  406 SDSKPDltKARMLLDRAFNL 425
Cdd:COG4783   84 KAGDYD--EALALLEKALKL 101
MAP7 pfam05672
MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is ...
 839-914 2.12e-04

MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilising protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.


Pssm-ID: 461709 [Multi-domain]  Cd Length: 153  Bit Score: 42.72  E-value: 2.12e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    839 EQRAKMAKNTTKRQLERAIQAQIEYEKS----VAAKLEDARiQREKEKARRLAEEEALLKEKQERERQLQEERQKMQEEV 914
Cdd:pfam05672   30 EEQERLEKEEEERLRKEELRRRAEEERArreeEARRLEEER-RREEEERQRKAEEEAEEREQREQEEQERLQKQKEEAEA 108
CAF-1_p150 pfam11600
Chromatin assembly factor 1 complex p150 subunit, N-terminal; CAF-1_p150 is a polypeptide ...
 836-937 2.16e-04

Chromatin assembly factor 1 complex p150 subunit, N-terminal; CAF-1_p150 is a polypeptide subunit of CAF-1, which functions in depositing newly synthesized and acetylated histones H3/H4 into chromatin during DNA replication and repair. CAF-1_p150 includes the HP1 interaction site, the PEST, KER and ED interacting sites. CAF-1_p150 interacts directly with newly synthesized and acetylated histones through the acidic KER and ED domains. The PEST domain is associated with proteins that undergo rapid proteolysis.


Pssm-ID: 402959 [Multi-domain]  Cd Length: 164  Bit Score: 43.14  E-value: 2.16e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    836 TSIEQRAKMAKNTTKRQLERAIQAQIEYEKSVAAKLED---ARIQREKEKARRLAEEEALLKEKQERERQ---------- 902
Cdd:pfam11600    6 SVQSQEEKEKQRLEKDKERLRRQLKLEAEKEEKERLKEeakAEKERAKEEARRKKEEEKELKEKERREKKekdekekaek 85

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 19115532    903 --LQEERQKMQEEVLEWRKSQQKASEDDMSLSDDEEK 937
Cdd:pfam11600   86 lrLKEEKRKEKQEALEAKLEEKRKKEEEKRLKEEEKR 122
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
157-242 2.22e-04

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 41.31  E-value: 2.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  157 LENAARCFDFVLQKSGGNILGFLGKARILYAKGNYRSALKlYQRALVSNPQFkPDPRIGIGLCFWNLDMKTDALSAWTRV 236
Cdd:COG3063    8 LEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNN-AEALLNLAELLLELGDYDEALAYLERA 85


                 ....*.
gi 19115532  237 QQLDPK 242
Cdd:COG3063   86 LELDPS 91
CCDC34 pfam13904
Coiled-coil domain-containing protein 3; This family is found in eukaryotes; it has several ...
 845-938 2.39e-04

Coiled-coil domain-containing protein 3; This family is found in eukaryotes; it has several conserved tryptophan residues. The function is not known.


Pssm-ID: 464032 [Multi-domain]  Cd Length: 221  Bit Score: 43.54  E-value: 2.39e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    845 AKNTTKRQLERaiQAQIEYEKSVAAKLEdariQREKEkarRLAEeeallKEKQERERQLQEERQKM-QEEVLEW--RKSQ 921
Cdd:pfam13904   41 ARKLEGLKLER--QPLEAYENWLAAKQR----QRQKE---LQAQ-----KEEREKEEQEAELRKRLaKEKYQEWlqRKAR 106

                           90
                   ....*....|....*..
gi 19115532    922 QKASEDDMSLSDDEEKQ 938
Cdd:pfam13904  107 QQTKKREESHKQKAAES 123
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 826-924 3.22e-04

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 44.56  E-value: 3.22e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    826 VSVEHPpySPTSIEQRAKMAKNTTKRQLERAIQAQIEYEKSVAAKLEDARIQREK-EKA-----------RRLAEEEALL 893
Cdd:pfam15709  315 RSEEDP--SKALLEKREQEKASRDRLRAERAEMRRLEVERKRREQEEQRRLQQEQlERAekmreeleleqQRRFEEIRLR 392

                           90       100       110
                   ....*....|....*....|....*....|.
gi 19115532    894 KEKQERERQLQEERQKMQEevLEWRKSQQKA 924
Cdd:pfam15709  393 KQRLEEERQRQEEEERKQR--LQLQAAQERA 421
PRK12704 PRK12704
phosphodiesterase; Provisional
 837-938 4.09e-04

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 44.38  E-value: 4.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532   837 SIEQRAKMAKNTTKRQL-----ERAIQAQIEYEKSVA------AKLEDARIQRE---KEKARRLAEEEALLKEKQERERQ 902
Cdd:PRK12704   42 RILEEAKKEAEAIKKEAlleakEEIHKLRNEFEKELRerrnelQKLEKRLLQKEenlDRKLELLEKREEELEKKEKELEQ 121

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 19115532   903 LQEERQKMQEEVLEWRKSQQKASEDDMSLSDDEEKQ 938
Cdd:PRK12704  122 KQQELEKKEEELEELIEEQLQELERISGLTAEEAKE 157
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 850-938 4.90e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 44.16  E-value: 4.90e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  850 KRQLERAIQAQIEYEKSVAAkLEDARIQREKEKARRLAEEEALLKEKQERERQLQEERQKMQEEVLEWRKSQQKASEDDM 929
Cdd:COG1196  385 AEELLEALRAAAELAAQLEE-LEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLE 463


                 ....*....
gi 19115532  930 SLSDDEEKQ 938
Cdd:COG1196  464 LLAELLEEA 472
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 850-1016 5.21e-04

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 43.96  E-value: 5.21e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    850 KRQLERAIQAQIEYEKSVAAKLEDAR---IQR-EKEKAR---RLAEEEALLKEKQERERQLQEERQKMQEEVLEWRKSQQ 922
Cdd:pfam17380  408 EEERQRKIQQQKVEMEQIRAEQEEARqreVRRlEEERARemeRVRLEEQERQQQVERLRQQEEERKRKKLELEKEKRDRK 487

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    923 KASEDD-MSLSDDEEKQSGKKKKKDRKKRKSKSKQESSDSGVSEDDEIPLSDARNKTKKRRVNRRVISEEY--TFDQDSD 999
Cdd:pfam17380  488 RAEEQRrKILEKELEERKQAMIEEERKRKLLEKEMEERQKAIYEEERRREAEEERRKQQEMEERRRIQEQMrkATEERSR 567

                          170
                   ....*....|....*...
gi 19115532   1000 AEG-NQEEEVSRTIEEKQ 1016
Cdd:pfam17380  568 LEAmEREREMMRQIVESE 585
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 182-242 5.96e-04

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 40.36  E-value: 5.96e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19115532  182 ARILYAKGNYRSALKLYQRALVSNPQ--FKPDPRIGIGLCFWNLDMKTDALSAWTRVQQLDPK 242
Cdd:COG1729   37 GEAYYALGDYDEAAEAFEKLLKRYPDspKAPDALLKLGLSYLELGDYDKARATLEELIKKYPD 99
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 839-938 5.97e-04

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 43.79  E-value: 5.97e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    839 EQRAKMAKNTTKRQL------ERAIQAQIEYEKSV----------AAKLEDARIQREKEKARRLAEEEALLKEKQERER- 901
Cdd:pfam15709  398 EERQRQEEEERKQRLqlqaaqERARQQQEEFRRKLqelqrkkqqeEAERAEAEKQRQKELEMQLAEEQKRLMEMAEEERl 477

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 19115532    902 ----QLQEERQKMQEEVLEWRKSQQKAS----EDDMSLSDDEEKQ 938
Cdd:pfam15709  478 eyqrQKQEAEEKARLEAEERRQKEEEAArlalEEAMKQAQEQARQ 522
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 646-735 6.13e-04

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 40.36  E-value: 6.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  646 RQKLYIKAIQSYDQAIKFDPKNAHAAQ---GIAIILAQNRQFSKALLILSKVREAIKD----ATTLINIGNCLAELKQFS 718
Cdd:COG1729    5 KAGDYDEAIAAFKAFLKRYPNSPLAPDalyWLGEAYYALGDYDEAAEAFEKLLKRYPDspkaPDALLKLGLSYLELGDYD 84

                         90
                 ....*....|....*..
gi 19115532  719 RAIEVFETVYSSTGESD 735
Cdd:COG1729   85 KARATLEELIKKYPDSE 101
YqiK COG2268
Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];
838-916 9.82e-04

Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];


Pssm-ID: 441869 [Multi-domain]  Cd Length: 439  Bit Score: 42.94  E-value: 9.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  838 IEQRAKMAKNTTKRQLERAIQ-AQIEYEKSVAAKLEDARIQR-----EKEKARRLAEEEALLKEKQERERQLQEERQKMQ 911
Cdd:COG2268  249 KKAEERREAETARAEAEAAYEiAEANAEREVQRQLEIAEREReielqEKEAEREEAELEADVRKPAEAEKQAAEAEAEAE 328


                 ....*
gi 19115532  912 EEVLE 916
Cdd:COG2268  329 AEAIR 333
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
335-422 1.01e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 39.38  E-value: 1.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  335 AYHQMGNNEKAMASYQKAKAADDRHLLSSVGIGQIQILQNDLTSAkLTFERIAEQNQSCFEALVVLGCLHAsdSKPDLTK 414
Cdd:COG3063    1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEA-IALEKALKLDPNNAEALLNLAELLL--ELGDYDE 77


                 ....*...
gi 19115532  415 ARMLLDRA 422
Cdd:COG3063   78 ALAYLERA 85
PTZ00121 PTZ00121
MAEBL; Provisional
 793-1039 1.11e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.21  E-value: 1.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532   793 ELIRQKPENSRTVEDLNFAMQQLDASIETFTKLVSVEHPPYsptsiEQRAKMAKNTTKRQLERAIQA-QIEYEKSVAAKL 871
Cdd:PTZ00121 1561 EEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLY-----EEEKKMKAEEAKKAEEAKIKAeELKKAEEEKKKV 1635

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532   872 EDARIQREKE--KARRLAEEEALLKEKQERERQLQEERQKMQEEVLEWRKSQQKASEDDMSLSDDEEKQSGKKKKKDRKK 949
Cdd:PTZ00121 1636 EQLKKKEAEEkkKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEK 1715

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532   950 RKSKSKQESSDSGVSEDDEIPLSDARNKTK----------KRRVNRRVISEEYTFDQDSDA------EGNQEEEVSRTIE 1013
Cdd:PTZ00121 1716 KKAEELKKAEEENKIKAEEAKKEAEEDKKKaeeakkdeeeKKKIAHLKKEEEKKAEEIRKEkeavieEELDEEDEKRRME 1795

                         250       260       270
                  ....*....|....*....|....*....|.
gi 19115532  1014 -EKQDNDITDN----QDDNKELNLFSEEDEE 1039
Cdd:PTZ00121 1796 vDKKIKDIFDNfaniIEGGKEGNLVINDSKE 1826
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 839-1039 1.38e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 42.62  E-value: 1.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  839 EQRAKMAKNTTKRQLERAIQAQIEYEKSVAAKLEDARIQREKEKARRLAEEEALLKEKQERERQLQEERQKMQEEVLEWR 918
Cdd:COG1196  275 ELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELE 354

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  919 KSQQKASEDDMSLSDDEEKQSGKKKKKDRKKRKSKSKQESSDSGVSEDDEIPLSDARNKTKKRRVNRRVISEEytfdqDS 998
Cdd:COG1196  355 EAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELE-----EA 429

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 19115532  999 DAEGNQEEEVSRTIEEKQDNDITDNQDDNKELNLFSEEDEE 1039
Cdd:COG1196  430 LAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLE 470
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 461-725 1.51e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 41.64  E-value: 1.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  461 RALDFLESAHmsvgpELLNNIAVLQYHLGLIPEAHGNIIKAKSV---LPDANPELSLLLdYNLARCEEELGNTSVASEAY 537
Cdd:COG2956   26 KAIDLLEEAL-----ELDPETVEAHLALGNLYRRRGEYDRAIRIhqkLLERDPDRAEAL-LELAQDYLKAGLLDRAEELL 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  538 VSILEKHPSFIDARIR--KCLLQLSNPNE--ETFKEIRHIMNADSQNLEVRAFfgwYLSKQKRrpvEDPEVRHCSQTLRH 613
Cdd:COG2956  100 EKLLELDPDDAEALRLlaEIYEQEGDWEKaiEVLERLLKLGPENAHAYCELAE---LYLEQGD---YDEAIEALEKALKL 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  614 WHDDIYSLVQLGNAYMRQARefrvhndreklkrqklYIKAIQSYDQAIKFDPKNAHAAQGIAIILAQNRQFSKALLILSK 693
Cdd:COG2956  174 DPDCARALLLLAELYLEQGD----------------YEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRK 237

                        250       260       270
                 ....*....|....*....|....*....|..
gi 19115532  694 VREAIKDATTLINIGNCLAELKQFSRAIEVFE 725
Cdd:COG2956  238 ALELDPSDDLLLALADLLERKEGLEAALALLE 269
BamD COG4105
Outer membrane protein assembly factor BamD, BamD/ComL family [Cell wall/membrane/envelope ...
 181-350 1.53e-03

Outer membrane protein assembly factor BamD, BamD/ComL family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443281 [Multi-domain]  Cd Length: 254  Bit Score: 41.40  E-value: 1.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  181 KARILYAKGNYRSALKLYQrALVSNPQFKP---DPRIGIGLCFWNLDMKTDALSAWTRVQQLDPKNTVVDT---YIGLYY 254
Cdd:COG4105   38 EAKEALEKGDYEKAIKLFE-ELEPRYPGSPyaeQAQLMLAYAYYKQGDYEEAIAAADRFIKLYPNSPNADYayyLRGLSY 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  255 YDL-------------AFQNVNNdsFVQNY---GKALQHIQRAFKTRNNdpVASSILE--RYVYSKKNYEGCIKLAENVI 316
Cdd:COG4105  117 YEQspdsdrdqtstrkAIEAFQE--LINRYpdsEYAEDAKKRIDELRDK--LARKELEvaRYYLKRGAYVAAINRFQNVL 192

                        170       180       190
                 ....*....|....*....|....*....|....
gi 19115532  317 QNSFSSSLIADGYYWMGRAYHQMGNNEKAMASYQ 350
Cdd:COG4105  193 EDYPDTPAVEEALYLLVEAYYALGRYDEAQDAAA 226
V-ATPase_G_2 pfam16999
Vacuolar (H+)-ATPase G subunit; This family represents vacuolar (H+)-ATPase G subunit from ...
 862-927 1.58e-03

Vacuolar (H+)-ATPase G subunit; This family represents vacuolar (H+)-ATPase G subunit from several bacterial and archaeal species. Subunit G is a component of the peripheral stalk of the ATPase complex


Pssm-ID: 339878 [Multi-domain]  Cd Length: 104  Bit Score: 38.96  E-value: 1.58e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19115532    862 EYEKSVAAKLEDARIQREKEKARRLAEEEALLKEKQERERQLQEE-RQKMQEEVLEWR-KSQQKASED 927
Cdd:pfam16999   12 EREAALDQQIEAARKEAEREVEAAEAEAARILREAEAKAKALQAEyRQELAAETARIReEARARAEAE 79
TAF4 pfam05236
Transcription initiation factor TFIID component TAF4 family; This region of similarity is ...
 874-930 1.69e-03

Transcription initiation factor TFIID component TAF4 family; This region of similarity is found in Transcription initiation factor TFIID component TAF4.


Pssm-ID: 461598 [Multi-domain]  Cd Length: 264  Bit Score: 41.49  E-value: 1.69e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 19115532    874 ARIQREKEKARRLAEEEALLKEKQERERQLQEERQKMQEEVlewrKSQQKASEDDMS 930
Cdd:pfam05236  120 AQKDKEEEERRVAEEREGLLKAAKSRSNQEDPEQLKLKQEA----KEMQKEEDEKMR 172
CR6_interact pfam10147
Growth arrest and DNA-damage-inducible proteins-interacting protein 1; Members of this family ...
 849-927 1.89e-03

Growth arrest and DNA-damage-inducible proteins-interacting protein 1; Members of this family of proteins act as negative regulators of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occur also in the absence of GADD45 proteins. Furthermore, they act as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity.


Pssm-ID: 431088 [Multi-domain]  Cd Length: 204  Bit Score: 40.61  E-value: 1.89e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19115532    849 TKRQLERAIQAQIEYEKSVAAKLEDARIQREKEKARRlaeeeallkekQERERQLQEERQKMQEEVLEWRKSQQKASED 927
Cdd:pfam10147   71 SAEQLEELEAEEREWYPSLAQMLESNRAQKAEKEARR-----------QAREQEIAKKMAKMPQWIADWNAQKAKREAE 138
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 157-241 2.24e-03

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 39.94  E-value: 2.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  157 LENAARCFDFVLQKSGGNILGFLGKARILYAKGNYRSALKLYQRALVSNPQFkPDPRIGIGLCFWNLDMKTDALSAWTRV 236
Cdd:COG5010   70 FEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDN-PNAYSNLAALLLSLGQDDEAKAALQRA 148


                 ....*
gi 19115532  237 QQLDP 241
Cdd:COG5010  149 LGTSP 153
TPR_8 pfam13181
Tetratricopeptide repeat;
326-352 3.07e-03

Tetratricopeptide repeat;


Pssm-ID: 404131 [Multi-domain]  Cd Length: 33  Bit Score: 36.22  E-value: 3.07e-03
                           10        20
                   ....*....|....*....|....*..
gi 19115532    326 ADGYYWMGRAYHQMGNNEKAMASYQKA 352
Cdd:pfam13181    1 AEAYYNLGLIYLKLGDYEEAKEYYEKA 27
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 175-704 3.22e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 41.61  E-value: 3.22e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    175 ILGFLGkaRILYAKGNYRSALKLYQRALVSNPQfKPDPRIGIGLCFWNLDMKTDALSAWTRVQQLDPKNTVVDTYIGLYY 254
Cdd:TIGR02917  365 ALSLLG--EAYLALGDFEKAAEYLAKATELDPE-NAAARTQLGISKLSQGDPSEAIADLETAAQLDPELGRADLLLILSY 441

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    255 YD-------LAFQ-----NVNNDSFVQN-----------YGKALQHIQRAFKTRNNDPVASSILERYVYSKKNYEGCIKL 311
Cdd:TIGR02917  442 LRsgqfdkaLAAAkklekKQPDNASLHNllgaiylgkgdLAKAREAFEKALSIEPDFFPAAANLARIDIQEGNPDDAIQR 521

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    312 AENVIQNSFSSSLIADGYywmGRAYHQMGNNEKAMASYQKAKAADD----------RHLLSS------------------ 363
Cdd:TIGR02917  522 FEKVLTIDPKNLRAILAL---AGLYLRTGNEEEAVAWLEKAAELNPqeiepalalaQYYLGKgqlkkalailneaadaap 598

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    364 ------VGIGQIQILQNDLTSAKLTFERIAEQNQSCFEALVVLGclHASDSKPDLTKARMLLDRAFNLvgssklprvvDS 437
Cdd:TIGR02917  599 dspeawLMLGRAQLAAGDLNKAVSSFKKLLALQPDSALALLLLA--DAYAVMKNYAKAITSLKRALEL----------KP 666

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    438 DLYITQARLWEKEDTKKSLGFLTRALDFLESAHMS--VGPELLNNIAVLQYHLgliPEAHGNIIKAKSVLPDAnpelslL 515
Cdd:TIGR02917  667 DNTEAQIGLAQLLLAAKRTESAKKIAKSLQKQHPKaaLGFELEGDLYLRQKDY---PAAIQAYRKALKRAPSS------Q 737

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    516 LDYNLARCEEELGNTSVASEAYVSILEKHPSfiDARIRKCLLQLsnpneetfkeirhimnadsqnlevraffgwYLSKQK 595
Cdd:TIGR02917  738 NAIKLHRALLASGNTAEAVKTLEAWLKTHPN--DAVLRTALAEL------------------------------YLAQKD 785

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    596 rrpvEDPEVRHCSQTLRHWHDDIYSLVQLGNAYMRQAREfrvhndreklkrqklyiKAIQSYDQAIKFDPKNAHAAQGIA 675
Cdd:TIGR02917  786 ----YDKAIKHYQTVVKKAPDNAVVLNNLAWLYLELKDP-----------------RALEYAERALKLAPNIPAILDTLG 844

                          570       580
                   ....*....|....*....|....*....
gi 19115532    676 IILAQNRQFSKALLILSKVREAIKDATTL 704
Cdd:TIGR02917  845 WLLVEKGEADRALPLLRKAVNIAPEAAAI 873
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 850-913 3.39e-03

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 41.06  E-value: 3.39e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 19115532    850 KRQLERAIQAQIEYEKSVAAKLEDARIQREKEKARRLAEEEALLKEKQERERQLQEERQKMQEE 913
Cdd:pfam13868  278 QEEAEKRRMKRLEHRRELEKQIEEREEQRAAEREEELEEGERLREEEAERRERIEEERQKKLKE 341
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 183-281 5.14e-03

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 38.79  E-value: 5.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  183 RILYAKGNYRSALKLYQRALVSNPQFkPDPRIGIGLCFWNLDMKTDALSAWTRVQQLDPKNTVVDTYIGLYYYDLafqnv 262
Cdd:COG5010   62 NLYNKLGDFEESLALLEQALQLDPNN-PELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSL----- 135

                         90
                 ....*....|....*....
gi 19115532  263 nndsfvQNYGKALQHIQRA 281
Cdd:COG5010  136 ------GQDDEAKAALQRA 148
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 157-243 5.19e-03

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 40.75  E-value: 5.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  157 LENAARCFDFVLQKSGGNILGFLGKARILYAKGNYRSALKLYQRALVSNPQFkPDPRIGIGLCFWNLDMKTDALSAWTRV 236
Cdd:COG3914  128 LEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDN-AEALNNLGNALQDLGRLEEAIAAYRRA 206


                 ....*..
gi 19115532  237 QQLDPKN 243
Cdd:COG3914  207 LELDPDN 213
TPR_1 pfam00515
Tetratricopeptide repeat;
326-352 5.25e-03

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 35.47  E-value: 5.25e-03
                           10        20
                   ....*....|....*....|....*..
gi 19115532    326 ADGYYWMGRAYHQMGNNEKAMASYQKA 352
Cdd:pfam00515    1 AKALYNLGNAYFKLGKYDEALEYYEKA 27
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 849-938 5.59e-03

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 40.71  E-value: 5.59e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    849 TKRQLERAIQAQIEYEKSVAAKLEDARIQREKEKARRLAEEEaLLKEKQERErQLQEERQKMQEEVlewRKSQQKASEDD 928
Cdd:pfam15709  326 EKREQEKASRDRLRAERAEMRRLEVERKRREQEEQRRLQQEQ-LERAEKMRE-ELELEQQRRFEEI---RLRKQRLEEER 400

                           90
                   ....*....|
gi 19115532    929 MSLSDDEEKQ 938
Cdd:pfam15709  401 QRQEEEERKQ 410
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
828-926 5.59e-03

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 40.79  E-value: 5.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532   828 VEHPPYSPTSIEQRAKMAKNTTKRQLERAIQAQIE--YEKSVAAKLEDARIQREKEKA----RRLAEEEALLKEKQERER 901
Cdd:PRK02224  461 VEGSPHVETIEEDRERVEELEAELEDLEEEVEEVEerLERAEDLVEAEDRIERLEERRedleELIAERRETIEEKRERAE 540

                          90       100
                  ....*....|....*....|....*
gi 19115532   902 QLQEERQKMQEEVLEWRKSQQKASE 926
Cdd:PRK02224  541 ELRERAAELEAEAEEKREAAAEAEE 565
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 604-696 5.65e-03

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 38.79  E-value: 5.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  604 VRHCSQTLRHWHDDIYSLVQLGNAYMRQARefrvhndreklkrqklYIKAIQSYDQAIKFDPKNAHAAQGIAIILAQNRQ 683
Cdd:COG5010   74 LALLEQALQLDPNNPELYYNLALLYSRSGD----------------KDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQ 137

                         90
                 ....*....|...
gi 19115532  684 FSKALLILSKVRE 696
Cdd:COG5010  138 DDEAKAALQRALG 150
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 334-422 6.15e-03

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 38.40  E-value: 6.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  334 RAYHQMGNNEKAMASYQKAKAADDRHLLSSVGIGQIQILQNDLTSAKLTFERIAEQNQSCFEALVVLGCLHAsdSKPDLT 413
Cdd:COG5010   62 NLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLL--SLGQDD 139


                 ....*....
gi 19115532  414 KARMLLDRA 422
Cdd:COG5010  140 EAKAALQRA 148
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 840-1039 6.24e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 40.69  E-value: 6.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  840 QRAKMAKNTTKRQLERAiQAQIEYEKSVAAKLEDARIQREKEKARRLAEEEALLKEK----------QERERQLQEERQK 909
Cdd:COG1196  242 EELEAELEELEAELEEL-EAELAELEAELEELRLELEELELELEEAQAEEYELLAELarleqdiarlEERRRELEERLEE 320

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  910 MQEEVLEWRKSQQKASEDDMSLSDDEEKQSGKKKKKDRKKRKSKSKQESSDSGVSEDDEiplSDARNKTKKRRVNRRVIS 989
Cdd:COG1196  321 LEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEE---ELEELAEELLEALRAAAE 397

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 19115532  990 EEYTFDQDSDAEGNQEEEVSRTIEEKQDNDITDNQDDNKELNLFSEEDEE 1039
Cdd:COG1196  398 LAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEA 447
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 194-357 6.43e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 38.06  E-value: 6.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  194 ALKLYQRALVSNPQFkPDPRIGIGLCFWNLDMKTDALSAWTRVQQLDPKNTVVDTYIGLYYYDLAfqnvnndsfvqNYGK 273
Cdd:COG4235    2 AIARLRQALAANPND-AEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAG-----------DTEE 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  274 ALQHIQRAFKTRNNDPVAssileryvyskknyegciklaenviqnsfsssliadgYYWMGRAYHQMGNNEKAMASYQKAK 353
Cdd:COG4235   70 AEELLERALALDPDNPEA-------------------------------------LYLLGLAAFQQGDYAEAIAAWQKLL 112


                 ....
gi 19115532  354 AADD 357
Cdd:COG4235  113 ALLP 116
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 556-697 7.67e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 37.86  E-value: 7.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  556 LLQLSNPNEETFKEIRHIMNADSQNLEVRAFFGWYLSKQKRrpvEDPEVRHCSQTLRHWHDDIYSLVQLGNAYMRQARef 635
Cdd:COG4783   13 ALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGD---LDEAIVLLHEALELDPDEPEARLNLGLALLKAGD-- 87

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19115532  636 rvhndreklkrqklYIKAIQSYDQAIKFDPKNAHAAQGIAIILAQNRQFSKALLILSKVREA 697
Cdd:COG4783   88 --------------YDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALEL 135
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
184-283 8.06e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 36.69  E-value: 8.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  184 ILYAKGNYRSALKLYQRALVSNPQFkPDPRIGIGLCFWNLDMKTDALsAWTRVQQLDPKNTVVDTYIGLYYYDLafqnvn 263
Cdd:COG3063    1 LYLKLGDLEEAEEYYEKALELDPDN-ADALNNLGLLLLEQGRYDEAI-ALEKALKLDPNNAEALLNLAELLLEL------ 72

                         90       100
                 ....*....|....*....|
gi 19115532  264 ndsfvQNYGKALQHIQRAFK 283
Cdd:COG3063   73 -----GDYDEALAYLERALE 87
ClpA COG0542
ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein ...
 841-919 8.11e-03

ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440308 [Multi-domain]  Cd Length: 836  Bit Score: 40.06  E-value: 8.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  841 RAKMAKNTT---KRQLERAIqAQIEYEKSVAAKLEDARiqrEKEKARRLAEEEALLKEKQERERQLQEERQKMQEEVLEW 917
Cdd:COG0542  401 RVRMEIDSKpeeLDELERRL-EQLEIEKEALKKEQDEA---SFERLAELRDELAELEEELEALKARWEAEKELIEEIQEL 476


                 ..
gi 19115532  918 RK 919
Cdd:COG0542  477 KE 478
MAP7 pfam05672
MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is ...
 872-938 8.15e-03

MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilising protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.


Pssm-ID: 461709 [Multi-domain]  Cd Length: 153  Bit Score: 38.10  E-value: 8.15e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 19115532    872 EDARIQREKekaRRLAEEEallKEKQERERQLQEERQKMQEEVLEWRKSQQKASEDDMSLSDDEEKQ 938
Cdd:pfam05672   11 EAARILAEK---RRQAREQ---REREEQERLEKEEEERLRKEELRRRAEEERARREEEARRLEEERR 71
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 788-938 8.22e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 40.11  E-value: 8.22e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    788 QFQLCELIRQKPENSRTVEDLNFAMQQLDASIETFTKLVsvehppysptsiEQRAKMAKNTTKRQLERAIQAQIEYEKSV 867
Cdd:pfam17380  403 KVKILEEERQRKIQQQKVEMEQIRAEQEEARQREVRRLE------------EERAREMERVRLEEQERQQQVERLRQQEE 470

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19115532    868 AAKLEDARIQREKEKARRLAEEEALLKEKQERERQ---LQEERQ-KMQEEVLEWRksQQKASEDDMSLSDDEEKQ 938
Cdd:pfam17380  471 ERKRKKLELEKEKRDRKRAEEQRRKILEKELEERKqamIEEERKrKLLEKEMEER--QKAIYEEERRREAEEERR 543
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 616-770 8.48e-03

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 38.02  E-value: 8.48e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  616 DDIYSLVQLGNAYMRQAREFRVHNDREKLKRQKLYIKAIQSYDQAIKFDPKNAHAAQGIAIILAQNRQFSKALLILSKVR 695
Cdd:COG5010    2 RALEGFDRLPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQAL 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19115532  696 E-AIKDATTLINIGNCLAELKQFSRAIEVFETVYSSTGESDTygVLSCLGRVWLQRGRESKNVDYLKESVRYATLA 770
Cdd:COG5010   82 QlDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPN--AYSNLAALLLSLGQDDEAKAALQRALGTSPLK 155
Nop14 pfam04147
Nop14-like family; Emg1 and Nop14 are novel proteins whose interaction is required for the ...
 886-1039 8.75e-03

Nop14-like family; Emg1 and Nop14 are novel proteins whose interaction is required for the maturation of the 18S rRNA and for 40S ribosome production.


Pssm-ID: 461196  Cd Length: 835  Bit Score: 39.91  E-value: 8.75e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    886 LAEEEAllkekqERERQLQEERQK-MQ----EEVLEWRKSQQKASEDDmsLSDDEEKQSGKKKKKDRKKRKSKSKQESSD 960
Cdd:pfam04147  259 LAEEEK------ERLEKLEEERLRrMRgeedEEEEDGKKKKKHKSADD--LDDDFVVDDDDDDEEFGLGKGIKERPTATE 330

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19115532    961 SGVSEDDEIPLSDARNKTKkrrvnrrviSEEYTFDQDSDAEGNQEEevsrtiEEKQDNDITDNQDDNKELNLFSEEDEE 1039
Cdd:pfam04147  331 LGDEDEDDFIIDDDLVESE---------SDLELDEEEEDEEEEDDE------DEDEEEEEDDDDLSDLESEEDEEDDEF 394
PDCD7 pfam16021
Programmed cell death protein 7;
862-938 9.27e-03

Programmed cell death protein 7;


Pssm-ID: 464979 [Multi-domain]  Cd Length: 305  Bit Score: 39.32  E-value: 9.27e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    862 EYEKSVAAKLEdaRIQREKEKARRLAEE-EALLKEKQER----ERQLQEERQKMQEEVLEWRKSQQKASEDDMSLSDDEE 936
Cdd:pfam16021   62 ELLESLKRKLE--RRQKKRLRRKRRKEErKEEKKEEQERraerEAKIDKWRRKQIQEVEEKKRERELKLAADAVLSEVRK 139


                   ..
gi 19115532    937 KQ 938
Cdd:pfam16021  140 KQ 141
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
605-701 9.42e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 36.69  E-value: 9.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532  605 RHCSQTLRHWHDDIYSLVQLGNAYMRQARefrvhndreklkrqklYIKAIQsYDQAIKFDPKNAHAAQGIAIILAQNRQF 684
Cdd:COG3063   13 EYYEKALELDPDNADALNNLGLLLLEQGR----------------YDEAIA-LEKALKLDPNNAEALLNLAELLLELGDY 75

                         90
                 ....*....|....*..
gi 19115532  685 SKALLILSKVREAIKDA 701
Cdd:COG3063   76 DEALAYLERALELDPSA 92
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 838-926 9.83e-03

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 39.52  E-value: 9.83e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115532    838 IEQRAKMAKNTTKRQLERAIQAQIEYEKSVAAKLEDARIQREKEKARRL--------------AEEEALLKEKQERERQL 903
Cdd:pfam13868   49 MEEERERALEEEEEKEEERKEERKRYRQELEEQIEEREQKRQEEYEEKLqereqmdeiveriqEEDQAEAEEKLEKQRQL 128

                           90       100
                   ....*....|....*....|...
gi 19115532    904 QEERQKMQEEVLEWRKSQQKASE 926
Cdd:pfam13868  129 REEIDEFNEEQAEWKELEKEEER 151
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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