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Conserved domains on  [gi|19115582|ref|NP_594670|]
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transcription factor TFIIIA [Schizosaccharomyces pombe]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
1-374 2.96e-35

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 134.44  E-value: 2.96e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115582   1 MCHFNELSIEIESKNLRSAKKIFHCPYEECGKKYSRPSLLEQHLRTHSNERPFVCDYTGCSKAFYRKSHLKIHKRCHTNV 80
Cdd:COG5048  40 TDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSSSSNSND 119
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115582  81 KPFSCHYDGCDAQFYTQQHLERHIEVHRKPKPYACTWEGC--DECFSKHQQLRSHIS-----------ACHTHLLPYPCT 147
Cdd:COG5048 120 NNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVntPQSNSLHPPLPANSLskdpssnlsllISSNVSTSIPSS 199
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115582 148 YQDCELRFATKQKLQNHVNRAHEKIISYSCPHESCVGHEGFEKWSQLQNHIREAHVPSCSICGRQFKTAAHLRHHVVLHQ 227
Cdd:COG5048 200 SENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESD 279
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115582 228 TTLEERKTYHCPMEGCKKSFTRSSALKKHI-SVIH--EGNMAFHCDS--CGTKFGYKHMLQRHLERGTCKKAHKPYINEC 302
Cdd:COG5048 280 SSSEKGFSLPIKSKQCNISFSRSSPLTRHLrSVNHsgESLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNS 359
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19115582 303 GIKHDGIEG----VAIHDQKEKELSSNLVSDVAKKIINEVTGHGYKEAREYSCSFPECNYRFKRLYDMHRHLNSHH 374
Cdd:COG5048 360 SSKFSPLLNneppQSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLI 435
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
1-374 2.96e-35

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 134.44  E-value: 2.96e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115582   1 MCHFNELSIEIESKNLRSAKKIFHCPYEECGKKYSRPSLLEQHLRTHSNERPFVCDYTGCSKAFYRKSHLKIHKRCHTNV 80
Cdd:COG5048  40 TDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSSSSNSND 119
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115582  81 KPFSCHYDGCDAQFYTQQHLERHIEVHRKPKPYACTWEGC--DECFSKHQQLRSHIS-----------ACHTHLLPYPCT 147
Cdd:COG5048 120 NNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVntPQSNSLHPPLPANSLskdpssnlsllISSNVSTSIPSS 199
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115582 148 YQDCELRFATKQKLQNHVNRAHEKIISYSCPHESCVGHEGFEKWSQLQNHIREAHVPSCSICGRQFKTAAHLRHHVVLHQ 227
Cdd:COG5048 200 SENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESD 279
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115582 228 TTLEERKTYHCPMEGCKKSFTRSSALKKHI-SVIH--EGNMAFHCDS--CGTKFGYKHMLQRHLERGTCKKAHKPYINEC 302
Cdd:COG5048 280 SSSEKGFSLPIKSKQCNISFSRSSPLTRHLrSVNHsgESLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNS 359
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19115582 303 GIKHDGIEG----VAIHDQKEKELSSNLVSDVAKKIINEVTGHGYKEAREYSCSFPECNYRFKRLYDMHRHLNSHH 374
Cdd:COG5048 360 SSKFSPLLNneppQSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLI 435
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
1-374 2.96e-35

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 134.44  E-value: 2.96e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115582   1 MCHFNELSIEIESKNLRSAKKIFHCPYEECGKKYSRPSLLEQHLRTHSNERPFVCDYTGCSKAFYRKSHLKIHKRCHTNV 80
Cdd:COG5048  40 TDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSSSSNSND 119
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115582  81 KPFSCHYDGCDAQFYTQQHLERHIEVHRKPKPYACTWEGC--DECFSKHQQLRSHIS-----------ACHTHLLPYPCT 147
Cdd:COG5048 120 NNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVntPQSNSLHPPLPANSLskdpssnlsllISSNVSTSIPSS 199
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115582 148 YQDCELRFATKQKLQNHVNRAHEKIISYSCPHESCVGHEGFEKWSQLQNHIREAHVPSCSICGRQFKTAAHLRHHVVLHQ 227
Cdd:COG5048 200 SENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESD 279
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115582 228 TTLEERKTYHCPMEGCKKSFTRSSALKKHI-SVIH--EGNMAFHCDS--CGTKFGYKHMLQRHLERGTCKKAHKPYINEC 302
Cdd:COG5048 280 SSSEKGFSLPIKSKQCNISFSRSSPLTRHLrSVNHsgESLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNS 359
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19115582 303 GIKHDGIEG----VAIHDQKEKELSSNLVSDVAKKIINEVTGHGYKEAREYSCSFPECNYRFKRLYDMHRHLNSHH 374
Cdd:COG5048 360 SSKFSPLLNneppQSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLI 435
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
21-148 8.43e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.01  E-value: 8.43e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115582  21 KIFHCPYEECGKKYSRPSLLEQHLRTHSNERPFVCDYTGCSKAFYRKS----HLKIHKRCH-TNVKPFSCHYDGCDAQFY 95
Cdd:COG5048 320 KPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLnnepPQSLQQYKDlKNDKKSETLSNSCIRNFK 399
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 19115582  96 TQQHLERHIEVHRKPKPYACTWEGCDECFSKHQQLRSHISACHTHLLPYPCTY 148
Cdd:COG5048 400 RDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSIL 452
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
58-222 3.20e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.84  E-value: 3.20e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115582  58 TGCSKAFYRKSHLKIHKRC--HT--NVKPFSCHYDGCDAQFYTQQHLERHIEVHRKPKPYACTWEGCDECFS------KH 127
Cdd:COG5048 293 KQCNISFSRSSPLTRHLRSvnHSgeSLKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSpllnnePP 372
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115582 128 QQLRSHISACHTHllPYPCTYQDCELRFATKQKLQNHVNRaHEKIISYSCPHESCVGHEGFEKWSQLQNHIREAHVPSCS 207
Cdd:COG5048 373 QSLQQYKDLKNDK--KSETLSNSCIRNFKRDSNLSLHIIT-HLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC 449
                       170
                ....*....|....*
gi 19115582 208 ICGRQFKTAAHLRHH 222
Cdd:COG5048 450 SILKSFRRDLDLSNH 464
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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