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Conserved domains on  [gi|19111922|ref|NP_595130|]
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putative dipeptide transmembrane transporter [Schizosaccharomyces pombe]

Protein Classification

allantoate permease family MFS transporter( domain architecture ID 13023596)

allantoate permease family major facilitator superfamily (MFS) transporter may function as an anion:cation symporter of vitamins such as allantoate, nicotinate, panthotenate and biotin

CATH:  1.20.1250.20
Gene Ontology:  GO:0016020|GO:0055085|GO:0022857
PubMed:  18405355|23403214|18537473|26758938|26098515|26234418
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
 47-447 5.12e-167

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 477.51  E-value: 5.12e-167
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922  47 KTDLWVMPLLCLISAFQYMDKSTSNYSSIMGIRTDLNMVGNQYNWVGTSFYLGFMVFSLPLSTLLQKFPLSKVTSAFIVA 126
Cdd:cd17327   1 KLDLFILPLLCILYFLQYLDKSNISNAAVMGMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922 127 WGILMTLTCLVHSYASYIATRTLLGILESVITPAFVLFIAQWYRKEEQFFRMAFLVAWNGLGGLIGGSMSYGLYKRelEN 206
Cdd:cd17327  81 WGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKI--LG 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922 207 NLTMSPWRILFIITGLITIINGVFIFIHIPDEPSKAWFLSEKEKDLVLKRLDTDHAGLGSKKFKKYQILEACRDVRMYLY 286
Cdd:cd17327 159 VGGLAGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLTEEEKELAVERLRANQTGKGDQKFKWKQIKEAFKDPRTWLL 238

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922 287 FFLQIAVAIPNGGLSNFSSIMLKNLGYVKGKALLMNMPTSSISFAALTLFGLIPEFTNRRMDIALVGLAINLTSGSLIAF 366
Cdd:cd17327 239 FLFFFCSQITNNGISNFLPLILKSLGFYSLQTNLLSVPIGALGAVSLLIAALLSDRFKKRGLFAIFACVLALVGSIILLA 318

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922 367 AK-PTHAQLAGYWLFGISPIPYICILSCISSNSAGHTKKVFMSAVSMIGYCVGNMVGPQTFRSTQAPKYQGAKVSFVVCY 445
Cdd:cd17327 319 APnPPGAYFAAYILGGGSYAGFPILLSWISSNCAGYTKRATVLAIMLIFYNVGNIVAPQIFRAGDAPRYIPGNIALLVCA 398


                ..
gi 19111922 446 CV 447
Cdd:cd17327 399 CV 400
 
Name Accession Description Interval E-value
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
 47-447 5.12e-167

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 477.51  E-value: 5.12e-167
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922  47 KTDLWVMPLLCLISAFQYMDKSTSNYSSIMGIRTDLNMVGNQYNWVGTSFYLGFMVFSLPLSTLLQKFPLSKVTSAFIVA 126
Cdd:cd17327   1 KLDLFILPLLCILYFLQYLDKSNISNAAVMGMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922 127 WGILMTLTCLVHSYASYIATRTLLGILESVITPAFVLFIAQWYRKEEQFFRMAFLVAWNGLGGLIGGSMSYGLYKRelEN 206
Cdd:cd17327  81 WGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKI--LG 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922 207 NLTMSPWRILFIITGLITIINGVFIFIHIPDEPSKAWFLSEKEKDLVLKRLDTDHAGLGSKKFKKYQILEACRDVRMYLY 286
Cdd:cd17327 159 VGGLAGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLTEEEKELAVERLRANQTGKGDQKFKWKQIKEAFKDPRTWLL 238

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922 287 FFLQIAVAIPNGGLSNFSSIMLKNLGYVKGKALLMNMPTSSISFAALTLFGLIPEFTNRRMDIALVGLAINLTSGSLIAF 366
Cdd:cd17327 239 FLFFFCSQITNNGISNFLPLILKSLGFYSLQTNLLSVPIGALGAVSLLIAALLSDRFKKRGLFAIFACVLALVGSIILLA 318

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922 367 AK-PTHAQLAGYWLFGISPIPYICILSCISSNSAGHTKKVFMSAVSMIGYCVGNMVGPQTFRSTQAPKYQGAKVSFVVCY 445
Cdd:cd17327 319 APnPPGAYFAAYILGGGSYAGFPILLSWISSNCAGYTKRATVLAIMLIFYNVGNIVAPQIFRAGDAPRYIPGNIALLVCA 398


                ..
gi 19111922 446 CV 447
Cdd:cd17327 399 CV 400
2A0114 TIGR00893
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ...
 58-445 1.18e-72

D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273326 [Multi-domain]  Cd Length: 399  Bit Score: 235.69  E-value: 1.18e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922    58 LISAFQYMDKSTSNYSSIMgIRTDLNMVGNQYNWVGTSFYLGFMVFSLPLSTLLQKFPLSKVTSAFIVAWGILMTLTCLV 137
Cdd:TIGR00893   1 LVTVINYLDRANLSFAAPM-LQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922   138 HSYASYIATRTLLGILESVITPAFVLFIAQWYRKEEQFFRMAFLVAWNGLGGLIGGSMSYGLykrelennLTMSPWRILF 217
Cdd:TIGR00893  80 GAYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWI--------LIHFSWQWAF 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922   218 IITGLITIINGVFIFIHIPDEPSKAWFLSEKEKDLVLKRLDTDHAGLGSKKFKKYQILEACRDVRMYLYFFLQIAVAIPN 297
Cdd:TIGR00893 152 IIEGVLGIIWGVLWLKFIPDPPQKAKWLTEEEKYIVVGGLLAEQQGKGPSTPKKYQIKELLKDRRVWGLALGQFLVNIGL 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922   298 GGLSNFSSIMLKN-LGYVKGKALLMNMPTSSISFAALTLFGLIPEFTNRR-----MDIALVGLAINLTSGSLIAFAK--P 369
Cdd:TIGR00893 232 GFFLTWFPTYLVQeRGLSILEAGFMASLPGIVGFIGMILGGRLSDLLLRRgkslvFARKTAIIAGLVLSLLMFATNYvnI 311

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19111922   370 THAQLAGYWLFGISPIPYICILSCISSNSAGHTKKVFMSAVSMIGyCVGNMVGPQTFRSTQAPKYQGAKVSFVVCY 445
Cdd:TIGR00893 312 PYAALALVALGFFGLGAGAIGWALISDNAPGNIAGLTGGLINSLG-NLGGIVGPIVIGAIAATTGSFAGALMVVAA 386
MFS_1 pfam07690
Major Facilitator Superfamily;
56-423 1.58e-27

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 112.90  E-value: 1.58e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922    56 LCLISAFQYMDKSTSNYSSIMGIRTDLNMVGNQYNWVGTSFYLGFMVFSLPLSTLLQKFPLSKVTSAFIVAWGILMTLTC 135
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922   136 LVHSYASYIATRTLLGILESVITPAFVLFIAQWYRKEEQFFRMAFLVAWNGLGGLIGGSMSYGLYkrelennlTMSPWRI 215
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLA--------SLFGWRA 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922   216 LFIITGLITIINGVFIFihIPDEPSKAWFLSEKEKDLVLKRLdtdhaglgskkfkkyqILEACRDVRMYLYFFLQIAVAI 295
Cdd:pfam07690 153 AFLILAILSLLAAVLLL--LPRPPPESKRPKPAEEARLSLIV----------------AWKALLRDPVLWLLLALLLFGF 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922   296 PNGGLSNFSSIMLKNLGYVKGKALLMNMPTSSISFAALTLFGLIPEFTNRRMDIALVGLAINLTSGSL--IAFAKPTHAQ 373
Cdd:pfam07690 215 AFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLllLSLTLSSLWL 294

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 19111922   374 LAGYWLFGISPIPYICILSCISSNSAGHTKKVFMSAVSMIGYCVGNMVGP 423
Cdd:pfam07690 295 LLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
43-235 8.64e-22

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 96.48  E-value: 8.64e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922  43 KLKLKTDLWVMPLLCLISAFQYMDksTSNYSSIMG-IRTDLNMVGNQYNWVGTSFYLGFMVFSLPLSTLLQKFPLSKVTS 121
Cdd:COG2271   2 RAPSRYRWRILALLFLAYFLNYLD--RSNLSVAAPpLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLA 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922 122 AFIVAWGILMTLTCLVHSYASYIATRTLLGILESVITPAFVLFIAQWYRKEEQFFRMAFLVAWNGLGGLIGGSMSYGLyk 201
Cdd:COG2271  80 IGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWL-- 157

                       170       180       190
                ....*....|....*....|....*....|....
gi 19111922 202 relennLTMSPWRILFIITGLITIINGVFIFIHI 235
Cdd:COG2271 158 ------LAAFGWRAAFLILGLPGLLLALLRFWLL 185
 
Name Accession Description Interval E-value
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
 47-447 5.12e-167

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 477.51  E-value: 5.12e-167
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922  47 KTDLWVMPLLCLISAFQYMDKSTSNYSSIMGIRTDLNMVGNQYNWVGTSFYLGFMVFSLPLSTLLQKFPLSKVTSAFIVA 126
Cdd:cd17327   1 KLDLFILPLLCILYFLQYLDKSNISNAAVMGMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922 127 WGILMTLTCLVHSYASYIATRTLLGILESVITPAFVLFIAQWYRKEEQFFRMAFLVAWNGLGGLIGGSMSYGLYKRelEN 206
Cdd:cd17327  81 WGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKI--LG 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922 207 NLTMSPWRILFIITGLITIINGVFIFIHIPDEPSKAWFLSEKEKDLVLKRLDTDHAGLGSKKFKKYQILEACRDVRMYLY 286
Cdd:cd17327 159 VGGLAGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLTEEEKELAVERLRANQTGKGDQKFKWKQIKEAFKDPRTWLL 238

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922 287 FFLQIAVAIPNGGLSNFSSIMLKNLGYVKGKALLMNMPTSSISFAALTLFGLIPEFTNRRMDIALVGLAINLTSGSLIAF 366
Cdd:cd17327 239 FLFFFCSQITNNGISNFLPLILKSLGFYSLQTNLLSVPIGALGAVSLLIAALLSDRFKKRGLFAIFACVLALVGSIILLA 318

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922 367 AK-PTHAQLAGYWLFGISPIPYICILSCISSNSAGHTKKVFMSAVSMIGYCVGNMVGPQTFRSTQAPKYQGAKVSFVVCY 445
Cdd:cd17327 319 APnPPGAYFAAYILGGGSYAGFPILLSWISSNCAGYTKRATVLAIMLIFYNVGNIVAPQIFRAGDAPRYIPGNIALLVCA 398


                ..
gi 19111922 446 CV 447
Cdd:cd17327 399 CV 400
2A0114 TIGR00893
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ...
 58-445 1.18e-72

D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273326 [Multi-domain]  Cd Length: 399  Bit Score: 235.69  E-value: 1.18e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922    58 LISAFQYMDKSTSNYSSIMgIRTDLNMVGNQYNWVGTSFYLGFMVFSLPLSTLLQKFPLSKVTSAFIVAWGILMTLTCLV 137
Cdd:TIGR00893   1 LVTVINYLDRANLSFAAPM-LQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922   138 HSYASYIATRTLLGILESVITPAFVLFIAQWYRKEEQFFRMAFLVAWNGLGGLIGGSMSYGLykrelennLTMSPWRILF 217
Cdd:TIGR00893  80 GAYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWI--------LIHFSWQWAF 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922   218 IITGLITIINGVFIFIHIPDEPSKAWFLSEKEKDLVLKRLDTDHAGLGSKKFKKYQILEACRDVRMYLYFFLQIAVAIPN 297
Cdd:TIGR00893 152 IIEGVLGIIWGVLWLKFIPDPPQKAKWLTEEEKYIVVGGLLAEQQGKGPSTPKKYQIKELLKDRRVWGLALGQFLVNIGL 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922   298 GGLSNFSSIMLKN-LGYVKGKALLMNMPTSSISFAALTLFGLIPEFTNRR-----MDIALVGLAINLTSGSLIAFAK--P 369
Cdd:TIGR00893 232 GFFLTWFPTYLVQeRGLSILEAGFMASLPGIVGFIGMILGGRLSDLLLRRgkslvFARKTAIIAGLVLSLLMFATNYvnI 311

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19111922   370 THAQLAGYWLFGISPIPYICILSCISSNSAGHTKKVFMSAVSMIGyCVGNMVGPQTFRSTQAPKYQGAKVSFVVCY 445
Cdd:TIGR00893 312 PYAALALVALGFFGLGAGAIGWALISDNAPGNIAGLTGGLINSLG-NLGGIVGPIVIGAIAATTGSFAGALMVVAA 386
MFS_1 pfam07690
Major Facilitator Superfamily;
56-423 1.58e-27

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 112.90  E-value: 1.58e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922    56 LCLISAFQYMDKSTSNYSSIMGIRTDLNMVGNQYNWVGTSFYLGFMVFSLPLSTLLQKFPLSKVTSAFIVAWGILMTLTC 135
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922   136 LVHSYASYIATRTLLGILESVITPAFVLFIAQWYRKEEQFFRMAFLVAWNGLGGLIGGSMSYGLYkrelennlTMSPWRI 215
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLA--------SLFGWRA 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922   216 LFIITGLITIINGVFIFihIPDEPSKAWFLSEKEKDLVLKRLdtdhaglgskkfkkyqILEACRDVRMYLYFFLQIAVAI 295
Cdd:pfam07690 153 AFLILAILSLLAAVLLL--LPRPPPESKRPKPAEEARLSLIV----------------AWKALLRDPVLWLLLALLLFGF 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922   296 PNGGLSNFSSIMLKNLGYVKGKALLMNMPTSSISFAALTLFGLIPEFTNRRMDIALVGLAINLTSGSL--IAFAKPTHAQ 373
Cdd:pfam07690 215 AFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLllLSLTLSSLWL 294

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 19111922   374 LAGYWLFGISPIPYICILSCISSNSAGHTKKVFMSAVSMIGYCVGNMVGP 423
Cdd:pfam07690 295 LLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 50-236 2.57e-22

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 98.03  E-value: 2.57e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922  50 LWVMPLLCLISAFQYMDKSTSnysSIMG--IRTDLNMVGNQYNWVGTSFYLGFMVFSLPLSTLLQKFPLSKVTSAFIVAW 127
Cdd:cd17319   2 WRIIPLLFLAYVINYLDRVNI---SVAAptIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLW 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922 128 GILMTLTCLVHSYASYIATRTLLGILESVITPAFVLFIAQWYRKEEQFFRMAFLVAWNGLGGLIGGSMSYGLykrelenn 207
Cdd:cd17319  79 SLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWL-------- 150

                       170       180
                ....*....|....*....|....*....
gi 19111922 208 LTMSPWRILFIITGLITIINGVFIFIHIP 236
Cdd:cd17319 151 LLLFGWRWAFIIEGLLGLLLAVLWWFYLR 179
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
43-235 8.64e-22

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 96.48  E-value: 8.64e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922  43 KLKLKTDLWVMPLLCLISAFQYMDksTSNYSSIMG-IRTDLNMVGNQYNWVGTSFYLGFMVFSLPLSTLLQKFPLSKVTS 121
Cdd:COG2271   2 RAPSRYRWRILALLFLAYFLNYLD--RSNLSVAAPpLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLA 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922 122 AFIVAWGILMTLTCLVHSYASYIATRTLLGILESVITPAFVLFIAQWYRKEEQFFRMAFLVAWNGLGGLIGGSMSYGLyk 201
Cdd:COG2271  80 IGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWL-- 157

                       170       180       190
                ....*....|....*....|....*....|....
gi 19111922 202 relennLTMSPWRILFIITGLITIINGVFIFIHI 235
Cdd:COG2271 158 ------LAAFGWRAAFLILGLPGLLLALLRFWLL 185
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 56-423 1.29e-21

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 96.34  E-value: 1.29e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922  56 LCLISAFQYMDkSTSNYSSIMGIRTDLNMVGNQYNWVGTSFYLGFMVFSLPLSTLLQKFPLSKVTSAFIVAWGILMTLTC 135
Cdd:cd06174   1 LLLGFFLTGLA-RGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922 136 LVHSYASYIATRTLLGILESVITPAFVLFIAQWYRKEEQFFRMAFLVAWNGLGGLIGGSMSYGLYKRelennlTMSPWRI 215
Cdd:cd06174  80 FAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASS------LGFGWRA 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922 216 LFIITGLITIINGVFIFIHIPDEPSKAwflSEKEKDLVLKRLDTDhaglgskkfkkyqILEACRDVRMYLYFFLQIAVAI 295
Cdd:cd06174 154 VFLIAAALALLAAILLLLVVPDPPESA---RAKNEEASSKSVLKL-------------LKRVLKNPGLWLLLLAIFLVNL 217

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922 296 PNGGLSNFSSIMLKNLGYVKGKALLMNMPTSSISFAALT-LFGLIPEFTNRRMDIALVGLAINLTSGSLIAFAKPTHAQL 374
Cdd:cd06174 218 AYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSlLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLL 297

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|
gi 19111922 375 AGYWLFGIS-PIPYICILSCISSNSAGHTKKVFMSAVSMIGYCvGNMVGP 423
Cdd:cd06174 298 LLLLLLGFGlGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFL-GGAIGP 346
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
78-415 1.71e-16

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 80.79  E-value: 1.71e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922  78 IRTDLNMVGNQYNWVGTSFYLGFMVFSLPLSTLLQKFPLSKVTSAFIVAWGILMTLTCLVHSYASYIATRTLLGILESVI 157
Cdd:COG2814  36 IAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGAL 115

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922 158 TPAFVLFIAQWYRKEEQFFRMAFLVAWNGLGGLIGGSMSYGLykrelennLTMSPWRILFIITGLITIINGVFIFIHIPD 237
Cdd:COG2814 116 FPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLL--------ADLFGWRWVFLVNAVLALLALLLLLRLLPE 187

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922 238 EPSKAwflsekekdlvlkrldtdhaglgsKKFKKYQILEACRDVRMYLYFFLQIAVAIPNGGLSNFSSIMLKN-LGYVKG 316
Cdd:COG2814 188 SRPAA------------------------RARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEvLGLSAS 243

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922 317 KALLMNMPTSSISFAALTLFGLIPEFTNRRMdIALVGLAINLTSGSLIAFAKPTHAQLAGYWLFGIS-PIPYICILSCIS 395
Cdd:COG2814 244 AAGLLLALFGLGGVLGALLAGRLADRFGRRR-LLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGfGLLFPLLQALVA 322

                       330       340
                ....*....|....*....|
gi 19111922 396 SNSAGHTKKVFMSAVSMIGY 415
Cdd:COG2814 323 ELAPPEARGRASGLYNSAFF 342
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
78-310 7.97e-13

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 69.91  E-value: 7.97e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922  78 IRTDLNMVGNQYNWVGTSFYLGFMVFSLPLSTLLQKFPLSKVTSAFIVAWGILMTLTCLVHSYASYIATRTLLGILESVI 157
Cdd:COG2223  31 LAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGS 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922 158 TPAFVLFIAQWYRKEEQFFRMAFLVAWNGLGGLIGGSMSYGLykrelennLTMSPWRILFIITGLITIINGVFIFIHIPD 237
Cdd:COG2223 111 FAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLL--------IAAFGWRNAFLILGILLLVVAVLAWLFLRD 182

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19111922 238 EPSKAWflsekekdlvlkrldtdhaglGSKKFKKYQILEACRDVRMYLYFFLQIAVAIPNGGLSNFSSIMLKN 310
Cdd:COG2223 183 PPAGAA---------------------AAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVD 234
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
78-423 2.49e-11

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 65.26  E-value: 2.49e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922  78 IRTDLNMVGNQYNWVGTSFYLGFMVFSLPLSTLLQKFPLSKVTSAFIVAWGILMTLTCLVHSYASYIATRTLLG----IL 153
Cdd:COG0738  34 LKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGlglgLL 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922 154 ESVITPafvlFIAQWYRkEEQFFRMAFLVAWNGLGGLIGGSMSYGLYKRELEnnltmSPWRILFIITGLITIINGVFIFI 233
Cdd:COG0738 114 DVAANP----YVAALGP-ETAASRLNLLHAFFSLGALLGPLLGGLLILLGLS-----LSWHLPYLILAVLLLLLALLFLR 183

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922 234 HipdepskawflsekekdlVLKRLDTDHAGLGSKKFKKYQILeacRDVRMYLYFFLQIAVAIPNGGLSNFSSIMLKN-LG 312
Cdd:COG0738 184 S------------------KLPEIEEEEEEAAGSAASLKSLL---KNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDvLG 242

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922 313 YVKGKALLMNmptsSISFAALTLFGLIPEFTNRRMDI--ALVGLAInLTSGSLIAFAKPTHAQLAGYWL----FGISPIp 386
Cdd:COG0738 243 LSEATAALGL----SLFWGGMTIGRFLGGFLLKRFGPvrLLRLSAL-LAAVGLLLALLAPGPWLALIGLalvgLGLSLM- 316

                       330       340       350
                ....*....|....*....|....*....|....*..
gi 19111922 387 YICILScISSNSAGHTKKVFMSAVSMIGYcVGNMVGP 423
Cdd:COG0738 317 FPTIFS-LALDGLGKRTAAAVSAVLIMGI-VGGAIGP 351
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 54-242 7.08e-09

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 57.63  E-value: 7.08e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922  54 PLLCLISAFQYMDKSTSNySSIMGIRTDLNmVGNQYN-WVGTSFYLGFMVFSLPLSTLLQKFPLSKVTSAFIVAWGILMT 132
Cdd:cd17328   2 AVLFLINLLNYMDRFTIA-GVLPDIQSDFL-IDDSLAgLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922 133 LTCLVHSYASYIATRTLLGILESVITPAFVLFIAQWYRKEEQ-----FFRMAFLVAwNGLGGLIGGSMSyglykrelenN 207
Cdd:cd17328  80 LSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRtralgVFYFAIPLG-SGLGYVVGGLVA----------Q 148

                       170       180       190
                ....*....|....*....|....*....|....*
gi 19111922 208 LTMSpWRILFIITGLITIINGVFIFIHIPDEPSKA 242
Cdd:cd17328 149 ATGG-WRWAFRVTGVLGVLLAILLLLFVREPPRGA 182
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 91-236 1.66e-08

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 56.41  E-value: 1.66e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922  91 WVGTSFYLGFMVFSLPLSTLLQKFPLSKVTSAFIVAWGI--LMTLTCLVHSYASYIATRTLLGILESVITPAFVLFIAQW 168
Cdd:cd17380  38 LVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLatLLTPLLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRW 117

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19111922 169 YRKEEQFFRMAFLVAWNGLGGLIGGSMSYGLykrelennLTMSPWRILFIITGLITIINGVFIFIHIP 236
Cdd:cd17380 118 VPVSERSRAVSIVTAGSYLGTLLGGLIGPLL--------LEYYGWPSVFYFFGLLGLLWALVWLIYLP 177
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 78-242 2.61e-08

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 55.71  E-value: 2.61e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922  78 IRTDLNMVGNQYNWVGTSFYLGFMVFSLPLSTLLQKFPLSKVTSAFIVAWGILMTLTCLVHSYASYIATRTLLGILESVI 157
Cdd:cd17475  22 LQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSV 101

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922 158 TPAFVLFIAQWYRKEEQFFRMAFLVAWNGLGGLIGG------SMSYGlykrelennltmspWRILFIITGLITIINGVFI 231
Cdd:cd17475 102 QPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAallpplALHYG--------------WRAAFVVAGLVSILAAVLF 167

                       170
                ....*....|.
gi 19111922 232 FIHIPDEPSKA 242
Cdd:cd17475 168 WLFYREPPAAS 178
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 51-232 6.34e-08

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 54.05  E-value: 6.34e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922  51 WVMPLLCLISAFQYMDksTSNYSSIMG-IRTDLNMVGNQYNWVGTSFYLGFMVFSLPLSTLLQKFPLSKVTSAFIVAWGI 129
Cdd:COG0477  14 RALLALALGTFLEGLD--FTIVNVALPsIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGL 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922 130 LMTLTCLVHSYASYIATRTLLGILESVITPAFVLFIAQWYRKEEQFFRMAFLVAWNGLGGLIGGSMSYGLykrelennLT 209
Cdd:COG0477  92 ASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLL--------VA 163

                       170       180
                ....*....|....*....|...
gi 19111922 210 MSPWRILFIITGLITIINGVFIF 232
Cdd:COG0477 164 ALGWRWIFLINAPLGLLALVLRL 186
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 80-382 1.14e-06

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 50.65  E-value: 1.14e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922  80 TDLNMVGNQYNWVGTSFYLGFMVFSLPLSTLLQKFPLSKVTSAFIVAWGILMTLTCLVHSYASYIATRTLLGILESVITP 159
Cdd:cd17325  24 ESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWP 103

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922 160 AFVLFIAQWYRKEEQFFRMAFLVAWNGLGGLIGGSMSYGLYKRelennltmSPWRILFIITGLITIINGVFIFIHIPDEP 239
Cdd:cd17325 104 AAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADA--------LGYRAPFLVCAALALLALVLALLLLPEPR 175

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922 240 SKAWflsekekdlvlkrldTDHAGLGSKKFKKYQILeacRDVRMYLYFFLQIAVAIPNGGLSNFSSIMLKNL-GYVKGKA 318
Cdd:cd17325 176 PPPN---------------KRAVSAARLRSGLRLLL---RDRRLLALFLAIFVLAFAFGALEPFLPLYAAELgGLSPAQI 237

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 19111922 319 LLMNMPTSSISFAALTLFGLIPEFTNRRMdIALVGLAINLTSGSLIAFAKPTHAQLAGYWLFGI 382
Cdd:cd17325 238 GLLFGAQGLASALSQPPAGKLSDRIGRKP-LILIGLLLSAVALLLLPLATSFWLLLLLLALLGL 300
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 77-246 6.36e-06

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 48.42  E-value: 6.36e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922  77 GIRTDLNMVGNQYNWVGTSFYLGFMVFSLPLSTLLQKFPLSKVTSAFIVAWGILMTLTCLVHSYASYIATRTLLGILESV 156
Cdd:cd17312  28 PIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGLFQSM 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922 157 ITPAFVLFIAQWYRKEEQFFRMAFLVAWNGLGGLIGG-SMSYGLYKRElennltmspWRILFIITGLITIINGVFIFIHI 235
Cdd:cd17312 108 GWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPiLAASLASYYG---------WRAAFLVPGIVGLVVAIILFFFL 178

                       170
                ....*....|.
gi 19111922 236 PDEPSKAWFLS 246
Cdd:cd17312 179 RDSPPYVWVLS 189
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 78-242 8.76e-06

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 47.93  E-value: 8.76e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922  78 IRTDLNMVGNQYNWVGTSFYLGFMVFSLPLSTLLQKFPLSKVTSAFIVAWGILMTLTCLVHSYASYIATRTLLGILESVI 157
Cdd:cd17324  25 IARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGF 104

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922 158 TPAFVLFIAQWYRKEEQFFRMAFLVAWNGLGGLIGGSMSyglykRELENNLTmspWRILFIITGLITIINGVFIFIHIPD 237
Cdd:cd17324 105 WAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLG-----GLLGQLLG---WRAAFLAIAVLALLAALLLWRLLPS 176


                ....*
gi 19111922 238 EPSKA 242
Cdd:cd17324 177 LPPKK 181
Sugar_tr pfam00083
Sugar (and other) transporter;
58-426 2.68e-04

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 43.41  E-value: 2.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922    58 LISAFQYMDKSTSNYSSiMGIRTDLNMVGNQYNWVGTSFYLGFMVFSLPLSTLLQKF---PLSKVTSAFIVAWGILMTLT 134
Cdd:pfam00083  18 VIGAFLTLIDFFKNFGL-SKSVSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFgrkKSLLIANVLFVIGAVLQGAA 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922   135 CLVHSYASYIATRTLLGI---LESVITPAFVLFIA-QWYRKeeqffrmaFLVAWNGLGGLIGGSMSYGLYkreLENNLTM 210
Cdd:pfam00083  97 KGKWSVYQLIVGRVLVGIgvgGASVLAPMYISEIApKKLRG--------ALGSLYQLAITFGILLAYIFG---LGLNKTS 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922   211 SP--WRILFIITGLITIIngVFIFIH-IPDEPskaWFLSEKEKDL----VLKRLDTD-----------HAGLGSKKFKKY 272
Cdd:pfam00083 166 NSdgWRIPLGLQLVPALL--LIIGLLfLPESP---RWLVEKGRLEeareVLAKLRGVpdvdreldeikDSLEAGQEAEKA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922   273 QILEACRDVRMYLYFFLQIAVAI---PNG--GLSNFSSIMLKNLGYVKGkaLLMNMPTSSISFAAlTLFG--LIPEFTNR 345
Cdd:pfam00083 241 SWKELFSTKTRRQRLLIGVMLQIfqqLTGinAIFYYSTTIFENLGLSDS--FLVTIIVGVVNFVF-TFIAifLVDRFGRR 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922   346 RMDIA-LVGLAINLTSGSLIAFAKPTHAQLAGY------------WLFGISPIPYIcILSCISSNsagHTKKVFMSAVSM 412
Cdd:pfam00083 318 PLLLLgAAGMAICFVILGIVALLGVSKSDWAGIvaivfialfiafFAMGWGPVPWV-IVSELFPL---SVRSKAMALATA 393

                         410
                  ....*....|....
gi 19111922   413 IGYcVGNMVGPQTF 426
Cdd:pfam00083 394 ANW-LANFLIGFLF 406
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 78-226 3.15e-04

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 42.93  E-value: 3.15e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922  78 IRTDLNMVGNQYNWVGTSFYLGFMVFSLPLSTLLQKFPLSKVtsaFIVAWGI--LMTLTC-LVHSYASYIATRTLLGILE 154
Cdd:cd17321  22 IARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRV---FLIGLALfgLASLLCaLAPSLAFLIAARALQGIGA 98

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 19111922 155 SVITPAFVLFIAQWYRKEEQ-----FFRMAFLVAWnGLGGLIGGSMsyglykrelennLTMSPWRILFIITGLITII 226
Cdd:cd17321  99 AAIMPASLALIAATFPGERRgralgLWGAVVGIGA-ALGPLLGGLL------------LELFGWRWIFLINVPIGLV 162
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 77-257 3.24e-04

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 43.11  E-value: 3.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922    77 GIRTDLNMVGNQYNWVGTSFYLGFMVFSLPLSTLLQKFPLSKVTSAFIVAWGILMTLTCLVHSYASYIATRTLLGI-LES 155
Cdd:TIGR00895  42 AISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLgLGG 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922   156 VITPAFVLFIAQWYRKEEQFFRMAFLVAWNgLGGLIGGSMSYGLykrelennLTMSPWRILFIITGLITIINGVFIFIHI 235
Cdd:TIGR00895 122 LMPNLNALVSEYAPKRFRGTAVGLMFCGYP-IGAAVGGFLAGWL--------IPVFGWRSLFYVGGIAPLLLLLLLMRFL 192

                         170       180
                  ....*....|....*....|..
gi 19111922   236 PdEPSKawFLSEKEKDLVLKRL 257
Cdd:TIGR00895 193 P-ESID--FLVSKRPETVRRIV 211
MFS_YjiJ cd06180
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ...
 88-241 6.12e-04

Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340869 [Multi-domain]  Cd Length: 371  Bit Score: 41.91  E-value: 6.12e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922  88 QYNWVGTSFYLGFMVFSLPLSTLLQKFPLSKVTSAFIVAWGILMTLTCLVHSYASYIATRTLLGILESVITPAFVLFIAQ 167
Cdd:cd06180  35 QAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFLAGAASAFVFVFGSNLVLH 114

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 19111922 168 WYRKEEQFFRMAFLVAWNGLGGLIGGSMSYGLYKRELEnnltmspWRILFIITGLITIINGVFIFIHIPDEPSK 241
Cdd:cd06180 115 HATAAGRGHLIGLLFAGVGLGIALSGLLVPAGLGGGLS-------WRAGWLALALLSAVLLLLSFLLLRRGPSA 181
MFS_SLC37A1_2 cd17344
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ...
 137-239 1.46e-03

Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340902 [Multi-domain]  Cd Length: 400  Bit Score: 40.76  E-value: 1.46e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922 137 VHSYASYIATRTLLGILESVITPAFVLFIAQWYRKEEQFFRMAFlvaWNG-------LGGLIGGSMsyglykreLENNLT 209
Cdd:cd17344 117 IHSLWYFVVVQILAGLFQSTGWPSVVACVGNWFGKGKRGLIMGI---WNShtsvgniLGSLIAGIF--------VSSAWG 185

                        90       100       110
                ....*....|....*....|....*....|
gi 19111922 210 MSpwrilFIITGLITIINGVFIFIHIPDEP 239
Cdd:cd17344 186 LS-----FIVPGIIIAAMGVLVFLFLVEHP 210
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 78-233 1.90e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 40.68  E-value: 1.90e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922  78 IRTDLNMVGNQYNWVGTSFYLGFMVFSLPLSTLLQKFPLSKVTSAFIVAWGILMTLTCLVHSYASYIATRTLLGILESVI 157
Cdd:cd06173 235 AKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLF 314

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922 158 TPAFVLFIAQWYRKEEQ-----FFRMAFLVAWnGLGGLIGGSMSYGLykrelennltmsPWRILFIITGLITIINGVFIF 232
Cdd:cd06173 315 NVPLNTLLQLRVPDELRgrvfsVYNALNSGAM-PLGALLAGLLADAL------------GLSAVFLLAGALLLLAALLLL 381


                .
gi 19111922 233 I 233
Cdd:cd06173 382 L 382
MFS_NRT2_like cd17341
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ...
 68-259 3.03e-03

Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340899 [Multi-domain]  Cd Length: 384  Bit Score: 39.93  E-value: 3.03e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922  68 STSNYSSIMG-IRTDLNMVGNQYNWVGTSFYLGFMVFSLPLSTLLQKFPLSKVTSAFIVAWGI-LMTLTCLVHSYASYIA 145
Cdd:cd17341  14 VWFLFAPLGPvIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIpLLALALAVSSYWGLLV 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922 146 TRTLLGILESVITPAfVLFIAQWYRKEEQFFRMAFLVAWNGLGGLIGGSMSYGLYKRELENNLTMSpWRILFIITGLITI 225
Cdd:cd17341  94 LGFLLGFAGANFASG-QPWASFWFPKEKIGGAAGGIAGAGNMGVAVSQLLAPLIAGAIVFDGGFVG-WRNAFFVPGILLA 171

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 19111922 226 INGVFIFIHIPDEPSKAWFLSEKEKDL--VLKRLDT 259
Cdd:cd17341 172 IAAVLVLLFGDDLPTGKASALEFLKVQlaVLKNYRT 207
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 79-157 6.96e-03

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 38.76  E-value: 6.96e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19111922  79 RTDLNMVGNQYNWVGTSFYLGFMVFSLPLSTLLQKFPLSKVTSAFIVAWGILMTLTCLVHSYASYIATRTLLGILESVI 157
Cdd:cd17313 273 SSHYGAGVRMGAWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWATI 351
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 92-239 8.58e-03

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 38.51  E-value: 8.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922    92 VGTSFYLGFMVFSLPLSTLLQKFPlSKVTSAF-IVAWGILMTLTCLVHSYASYIATRTLLGILESVITPAFVLFIAQWYR 170
Cdd:TIGR00881  35 LLSSFSIAYGISKFVMGSVSDRSN-PRVFLPIgLILCAIVNLFFGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTKWFS 113

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111922   171 KEEQFFRMAFL-VAWNGLGGLIGGSMSYGLYKrelennltMSPWRILFIITGLITIINGVFIFIHIPDEP 239
Cdd:TIGR00881 114 RSERGTWVSFWnCSHNVGGGLLPPLVLFGIAE--------LYSWHWVFIVPGIIAIIVSLICFLLLRDSP 175
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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