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Conserved domains on  [gi|63054750|ref|NP_595921|]
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TPR repeat-containing protein Oca3 [Schizosaccharomyces pombe]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 18641232)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  30708253|10517866
SCOP:  3001345

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 88-188 1.12e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 47.11  E-value: 1.12e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054750  88 KDAMSYYNSKLSEDPTHTVIYKRKLALLRSMGQTKECIQGLINYLDTFYNDLEAWAELADIYVSVEAFESAIFCYEEMVL 167
Cdd:COG4783  21 DEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALK 100

                        90       100
                ....*....|....*....|.
gi 63054750 168 LQPFEPRLFARLGDLYFVLAQ 188
Cdd:COG4783 101 LDPEHPEAYLRLARAYRALGR 121
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 51-281 1.37e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 42.41  E-value: 1.37e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054750  51 GETVLAKKCWNRLNDRFHKSPRVEGLYGMFLEATASEKDAMSYYNSKLSEDPTHTVIYKRKLALLRSMGQTKECIQGLIN 130
Cdd:COG2956  56 GEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLER 135

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054750 131 YLDTFYNDLEAWAELADIYVSVEAFESAIFCYEEMVLLQPFEPRLFARLGDLYfvLAQSNATNywfSLKHYCRSVEICEE 210
Cdd:COG2956 136 LLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELY--LEQGDYEE---AIAALERALEQDPD 210

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 63054750 211 YFHGWFGISKCCQQLLELSrtELKRLLskvnEKISDTFPDTESVRQLYQLSLKKSDLFAQKQPKLKALLEQ 281
Cdd:COG2956 211 YLPALPRLAELYEKLGDPE--EALELL----RKALELDPSDDLLLALADLLERKEGLEAALALLERQLRRH 275
 
Name Accession Description Interval E-value
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 88-188 1.12e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 47.11  E-value: 1.12e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054750  88 KDAMSYYNSKLSEDPTHTVIYKRKLALLRSMGQTKECIQGLINYLDTFYNDLEAWAELADIYVSVEAFESAIFCYEEMVL 167
Cdd:COG4783  21 DEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALK 100

                        90       100
                ....*....|....*....|.
gi 63054750 168 LQPFEPRLFARLGDLYFVLAQ 188
Cdd:COG4783 101 LDPEHPEAYLRLARAYRALGR 121
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 51-281 1.37e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 42.41  E-value: 1.37e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054750  51 GETVLAKKCWNRLNDRFHKSPRVEGLYGMFLEATASEKDAMSYYNSKLSEDPTHTVIYKRKLALLRSMGQTKECIQGLIN 130
Cdd:COG2956  56 GEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLER 135

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054750 131 YLDTFYNDLEAWAELADIYVSVEAFESAIFCYEEMVLLQPFEPRLFARLGDLYfvLAQSNATNywfSLKHYCRSVEICEE 210
Cdd:COG2956 136 LLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELY--LEQGDYEE---AIAALERALEQDPD 210

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 63054750 211 YFHGWFGISKCCQQLLELSrtELKRLLskvnEKISDTFPDTESVRQLYQLSLKKSDLFAQKQPKLKALLEQ 281
Cdd:COG2956 211 YLPALPRLAELYEKLGDPE--EALELL----RKALELDPSDDLLLALADLLERKEGLEAALALLERQLRRH 275
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 80-207 4.81e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 41.61  E-value: 4.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054750    80 FLEATASEKDAMSYYNSKLSEDPTHtviYKRKLALLRSM---GQTKECIQGLINYLDTFYNDLEAWAELADIYVSVEAFE 156
Cdd:TIGR02917 542 LYLRTGNEEEAVAWLEKAAELNPQE---IEPALALAQYYlgkGQLKKALAILNEAADAAPDSPEAWLMLGRAQLAAGDLN 618

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 63054750   157 SAIFCYEEMVLLQPFEPRLFARLGDlyfvlAQSNATNYWFSLKHYCRSVEI 207
Cdd:TIGR02917 619 KAVSSFKKLLALQPDSALALLLLAD-----AYAVMKNYAKAITSLKRALEL 664
 
Name Accession Description Interval E-value
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 88-188 1.12e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 47.11  E-value: 1.12e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054750  88 KDAMSYYNSKLSEDPTHTVIYKRKLALLRSMGQTKECIQGLINYLDTFYNDLEAWAELADIYVSVEAFESAIFCYEEMVL 167
Cdd:COG4783  21 DEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALK 100

                        90       100
                ....*....|....*....|.
gi 63054750 168 LQPFEPRLFARLGDLYFVLAQ 188
Cdd:COG4783 101 LDPEHPEAYLRLARAYRALGR 121
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 10-183 3.09e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 47.42  E-value: 3.09e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054750  10 DQNPQEIVALFSQQEAYAKLGKYKDeiwdvyqkvfiaalttgetvlAKKCWNRLNDRFHKSPRVEGLYGMFLEATASEKD 89
Cdd:COG2956  70 ERDPDRAEALLELAQDYLKAGLLDR---------------------AEELLEKLLELDPDDAEALRLLAEIYEQEGDWEK 128

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054750  90 AMSYYNSKLSEDPTHTVIYKRKLALLRSMGQTKECIQGLINYLDTFYNDLEAWAELADIYVSVEAFESAIFCYEEMVLLQ 169
Cdd:COG2956 129 AIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQD 208

                       170
                ....*....|....
gi 63054750 170 PFEPRLFARLGDLY 183
Cdd:COG2956 209 PDYLPALPRLAELY 222
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 125-191 3.48e-06

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 45.38  E-value: 3.48e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 63054750 125 IQGLINYLDTFYNDLEAWAELADIYVSVEAFESAIFCYEEMVLLQPFEPRLFARLGDLYFVLAQSNA 191
Cdd:COG4235   3 IARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEE 69
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 90-184 3.02e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 44.33  E-value: 3.02e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054750  90 AMSYYNSKLSEDPTHTVIYKRKLALLRSMGQTKECIQGLINYLDTFYNDLEAWAELADIYVSVEAFESAIFCYEEMVLLQ 169
Cdd:COG2956  27 AIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELD 106

                        90
                ....*....|....*
gi 63054750 170 PFEPRLFARLGDLYF 184
Cdd:COG2956 107 PDDAEALRLLAEIYE 121
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 113-239 4.28e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 42.49  E-value: 4.28e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054750 113 ALLRSMGQTKECIQGLINYLDTFYNDLEAWAELADIYVSVEAFESAIFCYEEMVLLQPFEPRLFARLGDLYFVLAQSNAt 192
Cdd:COG4783  12 QALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDE- 90

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 63054750 193 nywfSLKHYCRSVEICEEYFHGWFGISKCCQQL--LELSRTELKRLLSK 239
Cdd:COG4783  91 ----ALALLEKALKLDPEHPEAYLRLARAYRALgrPDEAIAALEKALEL 135
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
12-188 5.43e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 43.46  E-value: 5.43e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054750  12 NPQEIVALFSQQEAYAKLGKYKDEIwDVYQKvfiaALTtgetvLAKKCWNRLNDRfhksprveglyGMFLEATASEKDAM 91
Cdd:COG0457   4 DPDDAEAYNNLGLAYRRLGRYEEAI-EDYEK----ALE-----LDPDDAEALYNL-----------GLAYLRLGRYEEAL 62

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054750  92 SYYNSKLSEDPTHTVIYKRKLALLRSMGQTKECIQGLINYLDTFYNDLEAWAELADIYVSVEAFESAIFCYEEMVLLQPF 171
Cdd:COG0457  63 ADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPD 142

                       170
                ....*....|....*..
gi 63054750 172 EPRLFARLGDLYFVLAQ 188
Cdd:COG0457 143 DADALYNLGIALEKLGR 159
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 81-232 8.76e-05

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 43.83  E-value: 8.76e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054750  81 LEATASEKDAMSYYNSKLSEDPTHTVIYKRKLALLRSMGQTKECIQGLINYLDTFYNDLEAWAELADIYVSVEAFESAIF 160
Cdd:COG3914  88 LQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIA 167

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054750 161 CYEEMVLLQPFEPRLFARLGDLYFVLAQSNAtnywfSLKHYCRSVEICEEYFH-------------GWFGISKCCQQLLE 227
Cdd:COG3914 168 ALRRALELDPDNAEALNNLGNALQDLGRLEE-----AIAAYRRALELDPDNADahsnllfalrqacDWEVYDRFEELLAA 242


                ....*
gi 63054750 228 LSRTE 232
Cdd:COG3914 243 LARGP 247
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 90-184 9.61e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 42.79  E-value: 9.61e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054750  90 AMSYYNSKLSEDPTHTVIYkRKLALL-RSMGQTKECIQGLINYLDTFYNDLEAWAELADIYVSVEAFESAIFCYEEMVLL 168
Cdd:COG2956  61 AIRIHQKLLERDPDRAEAL-LELAQDyLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKL 139

                        90
                ....*....|....*.
gi 63054750 169 QPFEPRLFARLGDLYF 184
Cdd:COG2956 140 GPENAHAYCELAELYL 155
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 51-281 1.37e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 42.41  E-value: 1.37e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054750  51 GETVLAKKCWNRLNDRFHKSPRVEGLYGMFLEATASEKDAMSYYNSKLSEDPTHTVIYKRKLALLRSMGQTKECIQGLIN 130
Cdd:COG2956  56 GEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLER 135

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054750 131 YLDTFYNDLEAWAELADIYVSVEAFESAIFCYEEMVLLQPFEPRLFARLGDLYfvLAQSNATNywfSLKHYCRSVEICEE 210
Cdd:COG2956 136 LLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELY--LEQGDYEE---AIAALERALEQDPD 210

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 63054750 211 YFHGWFGISKCCQQLLELSrtELKRLLskvnEKISDTFPDTESVRQLYQLSLKKSDLFAQKQPKLKALLEQ 281
Cdd:COG2956 211 YLPALPRLAELYEKLGDPE--EALELL----RKALELDPSDDLLLALADLLERKEGLEAALALLERQLRRH 275
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
98-225 4.55e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 40.76  E-value: 4.55e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054750  98 LSEDPTHTVIYKRKLALLRSMGQTKECIQGLINYLDTFYNDLEAWAELADIYVSVEAFESAIFCYEEMVLLQPFEPRLFA 177
Cdd:COG0457   1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALN 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 63054750 178 RLGDLYFVLAQSNAtnywfSLKHYCRSVEICEEYFHGWFGISKCCQQL 225
Cdd:COG0457  81 NLGLALQALGRYEE-----ALEDYDKALELDPDDAEALYNLGLALLEL 123
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 80-207 4.81e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 41.61  E-value: 4.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054750    80 FLEATASEKDAMSYYNSKLSEDPTHtviYKRKLALLRSM---GQTKECIQGLINYLDTFYNDLEAWAELADIYVSVEAFE 156
Cdd:TIGR02917 542 LYLRTGNEEEAVAWLEKAAELNPQE---IEPALALAQYYlgkGQLKKALAILNEAADAAPDSPEAWLMLGRAQLAAGDLN 618

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 63054750   157 SAIFCYEEMVLLQPFEPRLFARLGDlyfvlAQSNATNYWFSLKHYCRSVEI 207
Cdd:TIGR02917 619 KAVSSFKKLLALQPDSALALLLLAD-----AYAVMKNYAKAITSLKRALEL 664
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 69-185 6.62e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 41.22  E-value: 6.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054750    69 KSPRVEGLYGMFLEATASEKDAMSYYNSKLSEDPTHTVIYKRKLALLRSMGQTKECIQGLINYLDTFYNDLEAWAELADI 148
Cdd:TIGR02917 599 DSPEAWLMLGRAQLAAGDLNKAVSSFKKLLALQPDSALALLLLADAYAVMKNYAKAITSLKRALELKPDNTEAQIGLAQL 678

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 63054750   149 YVSVEAFESAIFCYEEMVLLQPFEPRLFARLGDLYFV 185
Cdd:TIGR02917 679 LLAAKRTESAKKIAKSLQKQHPKAALGFELEGDLYLR 715
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 45-170 8.87e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 38.63  E-value: 8.87e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63054750  45 IAALTTGETVLAKKCWNRLNDRFHKSPRVEGLYGMFLEATASEKDAMSYYNSKLSEDPTHTVIYKRKLALLRSMGQTKEC 124
Cdd:COG4783  12 QALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEA 91

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 63054750 125 IQGLINYLDTFYNDLEAWAELADIYVSVEAFESAIFCYEEMVLLQP 170
Cdd:COG4783  92 LALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDP 137
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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